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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | increases expression | ISO | RGD:730906 | 6480464 | Catechin results in increased expression of STAT5B mRNA | CTD | PMID:15465739 | (S)-nicotine | increases expression | ISO | RGD:730906 | 6480464 | Nicotine results in increased expression of STAT5B mRNA | CTD | PMID:18805435 | 1-chloro-2,4-dinitrobenzene | increases expression | ISO | RGD:730906 | 6480464 | Dinitrochlorobenzene results in increased expression of STAT5B mRNA | CTD | PMID:17374397 | 2,3,7,8-tetrachlorodibenzodioxine | decreases phosphorylation | ISO | RGD:11352 | 6480464 | Tetrachlorodibenzodioxin results in decreased phosphorylation of STAT5B protein | CTD | PMID:19490989 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of STAT5B mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of STAT5B mRNA | CTD | PMID:11752688 PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of STAT5B mRNA | CTD | PMID:11752688 | 3,3',5-triiodo-L-thyronine | increases expression | EXP | | 6480464 | Triiodothyronine results in increased expression of STAT5B mRNA | CTD | PMID:15953391 | 3-methylcholanthrene | multiple interactions | ISO | RGD:730906 | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to STAT5B promoter] | CTD | PMID:20348232 | 4-vinylcyclohexene dioxide | affects expression | ISO | RGD:11352 | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of STAT5B mRNA | CTD | PMID:20829426 | acetylsalicylic acid | decreases expression | ISO | RGD:730906 | 6480464 | Aspirin results in decreased expression of STAT5B mRNA | CTD | PMID:15928584 | aflatoxin B1 | increases expression | ISO | RGD:11352 | 6480464 | Aflatoxin B1 results in increased expression of STAT5B mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | decreases expression | ISO | RGD:730906 | 6480464 | Tretinoin results in decreased expression of STAT5B mRNA | CTD | PMID:15498508 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of STAT5B mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:11352 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of STAT5B mRNA | CTD | PMID:21715664 | bisphenol A | decreases expression | ISO | RGD:730906 | 6480464 | bisphenol A results in decreased expression of STAT5B mRNA | CTD | PMID:22576693 | bisphenol A | increases methylation | ISO | RGD:730906 | 6480464 | bisphenol A results in increased methylation of STAT5B gene | CTD | PMID:22576693 | cobalt dichloride | decreases expression | ISO | RGD:730906 | 6480464 | cobaltous chloride results in decreased expression of STAT5B mRNA | CTD | PMID:19320972 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of STAT5B mRNA | CTD | PMID:20187946 | curcumin | increases cleavage | ISO | RGD:730906 | 6480464 | Curcumin results in increased cleavage of STAT5B protein | CTD | PMID:16959222 | curcumin | decreases expression | ISO | RGD:730906 | 6480464 | Curcumin results in decreased expression of STAT5B protein | CTD | PMID:16959222 | cyclophosphamide | decreases expression | ISO | RGD:11352 | 6480464 | Cyclophosphamide results in decreased expression of STAT5B mRNA | CTD | PMID:21041162 | dexamethasone | increases activity | ISO | RGD:730906 | 6480464 | Dexamethasone results in increased activity of STAT5B protein | CTD | PMID:14632786 | dexamethasone | decreases expression | ISO | RGD:11352 | 6480464 | Dexamethasone results in decreased expression of STAT5B mRNA | CTD | PMID:21041162 | diarsenic trioxide | decreases expression | ISO | RGD:730906 | 6480464 | arsenic trioxide results in decreased expression of STAT5B protein | CTD | PMID:18349030 | diethylstilbestrol | decreases expression | ISO | RGD:11352 | 6480464 | Diethylstilbestrol results in decreased expression of STAT5B mRNA | CTD | PMID:21041162 | eugenol | increases expression | ISO | RGD:730906 | 6480464 | Eugenol results in increased expression of STAT5B mRNA | CTD | PMID:17374397 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of STAT5B gene | CTD | PMID:22079235 | hexachlorobenzene | multiple interactions | ISO | RGD:730906 | 6480464 | [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of STAT5B protein]; more ... | CTD | PMID:21205633 | hexachlorobenzene | multiple interactions | EXP | | 6480464 | Hexachlorobenzene affects the expression of and affects the phosphorylation of STAT5B protein | CTD | PMID:22245120 | hydrogen peroxide | affects localization | ISO | RGD:730906 | 6480464 | Hydrogen Peroxide affects the localization of STAT5B protein | CTD | PMID:10364193 | indomethacin | increases expression | EXP | | 6480464 | Indomethacin results in increased expression of STAT5B mRNA | CTD | PMID:18299717 | nickel sulfate | increases expression | ISO | RGD:730906 | 6480464 | nickel sulfate results in increased expression of STAT5B mRNA | CTD | PMID:17374397 | nitric oxide | multiple interactions | ISO | RGD:11352 | 6480464 | STAT5B protein affects the reaction [Nitric Oxide results in decreased expression of ACO1 mRNA] | CTD | PMID:16886906 | nitric oxide | decreases expression | ISO | RGD:11352 | 6480464 | Nitric Oxide results in decreased expression of STAT5B protein | CTD | PMID:16886906 | progesterone | affects localization | ISO | RGD:730906 | 6480464 | Progesterone affects the localization of STAT5B protein | CTD | PMID:16175315 | progesterone | affects abundance | ISO | RGD:11352 | 6480464 | STAT5B protein affects the abundance of Progesterone | CTD | PMID:15471942 | progesterone | increases expression | ISO | RGD:730906 | 6480464 | Progesterone results in increased expression of STAT5B protein | CTD | PMID:16175315 | propiconazole | decreases expression | ISO | RGD:11352 | 6480464 | propiconazole results in decreased expression of STAT5B mRNA | CTD | PMID:21278054 PMID:19363144 | propiconazole | decreases expression | ISO | RGD:11352 | 6480464 | propiconazole results in decreased expression of STAT5B mRNA | CTD | PMID:19363144 PMID:21278054 | tamibarotene | decreases expression | ISO | RGD:730906 | 6480464 | Am 80 results in decreased expression of STAT5B mRNA; more ... | CTD | PMID:15498508 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of STAT5B mRNA | CTD | PMID:19448997 | trimellitic anhydride | increases expression | ISO | RGD:11352 | 6480464 | trimellitic anhydride results in increased expression of STAT5B mRNA | CTD | PMID:19042947 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Acute myeloid leukemia |
| Chemokine signaling pathway | |
| Chronic myeloid leukemia | |
| ErbB signaling pathway | |
| Hepatitis B | |
| HTLV-I infection | |
| Jak-STAT signaling pathway | |
| Measles | |
| Pathways in cancer | |
| Viral carcinogenesis | |
| Pathway Interaction Database | Angiopoietin receptor Tie2-mediated signaling (PID:200079) |
| CXCR4-mediated signaling events (PID:200099) | |
| EPO signaling pathway (PID:200183) | |
| ErbB4 signaling events (PID:200011) | |
| FGF signaling pathway (PID:200220) | |
| Glucocorticoid receptor regulatory network (PID:200091) | |
| GMCSF-mediated signaling events (PID:200019) | |
| IL2 signaling events mediated by STAT5 (PID:200184) | |
| IL2-mediated signaling events (PID:200098) | |
| IL3-mediated signaling events (PID:200145) | |
| IL4-mediated signaling events (PID:200022) | |
| IL5-mediated signaling events (PID:200107) | |
| PDGFR-beta signaling pathway (PID:200149) | |
| Signaling events mediated by PTP1B (PID:200042) | |
| Signaling events mediated by TCPTP (PID:200078) | |
References - curated| 1. |
Badger TM, etal., Endocrinology. 2003 Sep;144(9):3969-76. |
| 2. |
Cao H, etal., Circ Res. 2006 Apr 14;98(7):913-22. Epub 2006 Mar 9. |
| 3. |
Chen Y, etal., Am J Physiol Endocrinol Metab. 2007 Feb 27;. |
| 4. |
Gebert CA, etal., Mol Endocrinol. 1997 Apr;11(4):400-14. |
| 5. |
Gerland K, etal., Mol Cell Endocrinol. 2000 Oct 25;168(1-2):1-9. |
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GOA data from the GO Consortium |
| 7. |
Grigorov I, etal., Mol Biol Rep 2001;28(4):217-22. |
| 8. |
Jackerott M, etal., Diabetes. 2006 Oct;55(10):2705-12. |
| 9. |
Ji S, etal., J Biol Chem. 1999 May 7;274(19):13434-42. |
| 10. |
Kazansky AV, etal., Cancer Res. 2003 Dec 15;63(24):8757-62. |
| 11. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 12. |
MGD data from the GO Consortium |
| 13. |
Mihailovic M, etal., Acta Biochim Pol. 2007;54(2):331-40. Epub 2007 Jun 12. |
| 14. |
Murray PJ J Immunol. 2007 Mar 1;178(5):2623-9. |
| 15. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 16. |
Park SH and Waxman DJ, J Biol Chem 2001 Nov 16;276(46):43031-9. |
| 17. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 19. |
RGD automated data pipeline |
| 20. |
RGD automated import pipeline for gene-chemical interactions |
| 21. |
RGD Automated Pipelines |
| 22. |
Ripperger JA, etal., J Biol Chem 1995 Dec 15;270(50):29998-30006. |
| 23. |
Russell DL and Richards JS, Mol Endocrinol. 1999 Dec;13(12):2049-64. |
| 24. |
Sun SL, etal., Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1097-101. |
| 25. |
Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34 |
| 26. |
Timsit YE and Riddick DS, Endocrinology 2002 Sep;143(9):3284-94. |
| 27. |
Venge P, etal., Lancet 1977 Aug 20;2(8034):373-5. |
| 28. |
Volgin DV and Kubin L, Auton Neurosci. 2006 Jun 30;126-127:93-9. Epub 2006 May 26. |
| 29. |
Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91. |
References - uncurated| PubMed | 12682066 |
| 12767047 | |
| 14532269 | |
| 14761873 | |
| 15062567 | |
| 15142985 | |
| 15253383 | |
| 16303763 | |
| 16339156 | |
| 16857756 | |
| 17008382 | |
| 17332060 | |
| 20378540 | |
| 21592969 | |
| 23064763 | |
| 23071812 | |
| 23185594 | |
| 9341127 |
RGD Disease Portals| Stat5b has been annotated in the following RGD Disease Portals. |
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Candidate Gene Status | Stat5b is a candidate Gene for Eau3 |
| Stat5b is a candidate Gene for Pia10 |
| Stat5b is a candidate Gene for Ciaa2 |
Comparative Map Data| Stat5b (Rattus norvegicus) |
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| STAT5B (Homo sapiens) |
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| Stat5b (Mus musculus) |
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Position Markers| RH94818 |
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| RH142912 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_022380 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06065575 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06065576 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06065577 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01066016 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01066017 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01066018 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X91988 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X97541 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022380 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_071775 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_071775 | (Get FASTA) |
| GenBank Protein | CAA63042 | (Get FASTA) |
| CAA63043 | (Get FASTA) | |
| CAA66141 | (Get FASTA) | |
| EDM06066 | (Get FASTA) | |
| P52632 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000019075 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000026354 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000026354 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 25126 | ENTREZGENE |
| Gene3D-CATH | EF-Hand_type | UniProtKB/Swiss-Prot |
| SH2 | UniProtKB/Swiss-Prot | |
| STAT_alpha | UniProtKB/Swiss-Prot | |
| STAT_DNA_bd_sub | UniProtKB/Swiss-Prot | |
| STAT_protein_interaction | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000019075 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 55718 | ENTREZGENE |
| InterPro | EF-hand-like_dom | UniProtKB/Swiss-Prot |
| p53-like_TF_DNA-bd | UniProtKB/Swiss-Prot | |
| SH2 | UniProtKB/Swiss-Prot | |
| STAT_TF_alpha | UniProtKB/Swiss-Prot | |
| STAT_TF_coiled-coil | UniProtKB/Swiss-Prot | |
| STAT_TF_core | UniProtKB/Swiss-Prot | |
| STAT_TF_DNA-bd | UniProtKB/Swiss-Prot | |
| STAT_TF_DNA-bd_sub | UniProtKB/Swiss-Prot | |
| STAT_TF_prot_interaction | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:25126 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | STAT | UniProtKB/Swiss-Prot |
| Pfam | SH2 | UniProtKB/Swiss-Prot |
| STAT_alpha | UniProtKB/Swiss-Prot | |
| STAT_bind | UniProtKB/Swiss-Prot | |
| STAT_int | UniProtKB/Swiss-Prot | |
| PROSITE | SH2 | UniProtKB/Swiss-Prot |
| SMART | SH2 | UniProtKB/Swiss-Prot |
| STAT_int | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | P53_like_DNA_bnd | UniProtKB/Swiss-Prot |
| STAT | UniProtKB/Swiss-Prot | |
| STAT | UniProtKB/Swiss-Prot | |
| UniGene | Rn.54486 | ENTREZGENE |
| UniProt | STA5B_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2003-04-09 | Stat5b | signal transducer and activator of transcription 5B | signal transducer and activator of transcription 5b | Name updated | 2575 | APPROVED | |
| 2002-06-10 | Stat5b | signal transducer and activator of transcription 5b | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_drugs | independent of the effects of 3-methylcholanthrene in growth hormone induced chain of reactions on CYP2C11 gene expression | 628356 |
| gene_function | binds to the GAS element and activates prl-induced transcription | 70587 |
| gene_homology | aa sequence shows 26.7% identity with rat Stat3, 87.7% with sheep Stat5a, 92.5% with mouse Stat5a, and 98.7% with mouse Stat5b | 729990 |
| gene_process | involved in signal transduction and activation of transcription | 70587 |
| gene_process | may be a key intracellular mediator in the GH-pulse induced masculinization of liver CYP expression | 628356 |
| gene_regulation | HNF3beta inhibits Stat5b activation at the level of Stat5b tyrosine phosphorylation; Stat5b inhibits HNF3beta by an unknown mechanism; neither inhibition is dependent on DNA binding | 70587 |
| gene_regulation | growth hormone activation of Stat5b inhibits the transcription factor HNF3beta resulting in downregulation of Cyp2c11 | 70587 |
| gene_regulation | induced in hepatic nucleus by growth hormone | 628356 |
| gene_regulation | exposure of H4 hepatoma cells to growth hormone (GH) results in a reversible time-, concentration- and growth hormone receptor concentration-dependent increase in tyrosine phosphorylation of STAT5 | 625493 |
| gene_regulation | translocated to the nucleus in most subpopulations of hypothalamic dopaminergic neurons following ovine prolactin activation of prolactin receptors | 632713 |
| More on Stat5b | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3774 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.