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Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | biological_process | | ND | | 1598407 | | RGD | | defense response to Gram-positive bacterium | | ISO | RGD:733254 | 1624291 | MGI:MGI:96052 | RGD | MGI:MGI:65050 PMID:8125254 | defense response to Gram-positive bacterium | | ISS | UniProtKB:P14234 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | innate immune response | | IEA | UniProtKB-KW:KW-0399 | 1600115 | GO_REF:0000037 | UniProtKB | GO_REF:0000037 | integrin-mediated signaling pathway | | ISO | RGD:733254 | 1624291 | MGI:MGI:3640451|PMID:11672534 | RGD | MGI:MGI:3640451 PMID:11672534 | integrin-mediated signaling pathway | | ISS | UniProtKB:P14234 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | integrin-mediated signaling pathway | | ISO | RGD:733253 | 1624291 | PMID:7519620 | RGD | PMID:7519620 | integrin-mediated signaling pathway | | ISO | RGD:733253 | 1624291 | PMID:10739672 | RGD | PMID:10739672 | peptidyl-tyrosine phosphorylation | | ISO | RGD:733254 | 1624291 | MGI:MGI:3513574|PMID:15561106 | RGD | MGI:MGI:3513574 PMID:15561106 | peptidyl-tyrosine phosphorylation | | ISS | UniProtKB:P14234 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | peptidyl-tyrosine phosphorylation | | ISO | RGD:733253 | 1624291 | PMID:8327512 | RGD | PMID:8327512 | peptidyl-tyrosine phosphorylation | | ISO | RGD:733253 | 1624291 | PMID:7519620 | RGD | PMID:7519620 | positive regulation of cell migration | | ISO | RGD:733254 | 1624291 | MGI:MGI:3513574|PMID:15561106 | RGD | MGI:MGI:3513574 PMID:15561106 | positive regulation of cell migration | | ISS | UniProtKB:P14234 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | positive regulation of cytokine secretion | | ISO | RGD:733254 | 1624291 | MGI:MGI:5294498|PMID:21746961 | RGD | MGI:MGI:5294498 PMID:21746961 | positive regulation of cytokine secretion | | ISS | UniProtKB:P14234 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | positive regulation of mast cell degranulation | | ISO | RGD:733254 | 1624291 | MGI:MGI:5294498|PMID:21746961 | RGD | MGI:MGI:5294498 PMID:21746961 | positive regulation of mast cell degranulation | | ISS | UniProtKB:P14234 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | positive regulation of phosphatidylinositol 3-kinase activity | | ISO | RGD:733253 | 1624291 | PMID:10739672 | RGD | PMID:10739672 | positive regulation of phosphatidylinositol 3-kinase activity | | IEA | Ensembl:ENSP00000363117 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of phosphatidylinositol 3-kinase cascade | | ISO | RGD:733253 | 1624291 | PMID:10739672 | RGD | PMID:10739672 | positive regulation of phosphatidylinositol 3-kinase cascade | | IEA | Ensembl:ENSP00000363117 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | protein autophosphorylation | | ISO | RGD:733253 | 1624291 | PMID:2181286 | RGD | PMID:2181286 | protein autophosphorylation | | IEA | Ensembl:ENSP00000363117 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | protein autophosphorylation | | ISO | RGD:733253 | 1624291 | PMID:8327512 | RGD | PMID:8327512 | regulation of cell shape | | ISO | RGD:733254 | 1624291 | MGI:MGI:3640451|PMID:11672534 | RGD | MGI:MGI:3640451 PMID:11672534 | regulation of cell shape | | ISS | UniProtKB:P14234 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | regulation of innate immune response | | ISO | RGD:733254 | 1624291 | MGI:MGI:5294498|PMID:21746961 | RGD | MGI:MGI:5294498 PMID:21746961 | regulation of innate immune response | | ISS | UniProtKB:P14234 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | regulation of phagocytosis | | ISO | RGD:733254 | 1624291 | MGI:MGI:3640451|PMID:11672534 | RGD | MGI:MGI:3640451 PMID:11672534 | regulation of phagocytosis | | ISS | UniProtKB:P14234 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | regulation of protein kinase activity | | ISO | RGD:733254 | 1624291 | MGI:MGI:3640451|PMID:11672534 | RGD | MGI:MGI:3640451 PMID:11672534 | regulation of protein kinase activity | | ISS | UniProtKB:P14234 | 1600115 | GO_REF:0000024 | UniProtKB | GO_REF:0000024 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Epstein-Barr virus infection | |
| Pathway Interaction Database | Alpha-synuclein signaling (PID:200219) |
| amb2 Integrin signaling (PID:200127) | |
| Class I PI3K signaling events (PID:200116) | |
| CXCR4-mediated signaling events (PID:200099) | |
| EPHA forward signaling (PID:200142) | |
| Ephrin B reverse signaling (PID:200204) | |
| Glypican 1 network (PID:200026) | |
| IL8- and CXCR1-mediated signaling events (PID:200199) | |
| IL8- and CXCR2-mediated signaling events (PID:200167) | |
| PDGFR-beta signaling pathway (PID:200149) | |
| Regulation of p38-alpha and p38-beta (PID:200066) | |
| Signaling events mediated by PTP1B (PID:200042) | |
| Thromboxane A2 receptor signaling (PID:200082) | |
References - curated| 1. |
Brunati AM, etal., Eur J Biochem. 1995 Apr 1;229(1):164-70. |
| 2. |
Choi WS, etal., Mol Cell Biol 2004 Aug;24(16):6980-92. |
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GOA data from the GO Consortium |
| 4. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
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MGD data from the GO Consortium |
| 6. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
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Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
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RGD automated data pipeline |
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RGD automated import pipeline for gene-chemical interactions |
| 11. |
RGD comprehensive gene curation |
| 12. |
Stenberg PE, etal., Blood. 1997 Apr 1;89(7):2384-93. |
| 13. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
References - uncurated
RGD Disease Portals| Fgr has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Fgr (Rattus norvegicus) |
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| FGR (Homo sapiens) |
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| Fgr (Mus musculus) |
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Position Markers| D5Got83 |
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| RH142441 |
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| RH141155 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_024145 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06040261 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06040262 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01040088 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01040089 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01040090 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01040091 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01040092 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01040093 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01040094 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC062025 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473968 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234703 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X57018 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_024145 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_077059 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_077059 | (Get FASTA) |
| GenBank Protein | AAH62025 | (Get FASTA) |
| CAA40337 | (Get FASTA) | |
| EDL80655 | (Get FASTA) | |
| EDL80656 | (Get FASTA) | |
| EDL80657 | (Get FASTA) | |
| Q6P6U0 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000009912 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000013779 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000013778 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 79113 | ENTREZGENE |
| Gene3D-CATH | SH2 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 3842 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:5623501 | IMAGE-MGC_LOAD |
| InterPro | Kinase-like_dom | UniProtKB/Swiss-Prot |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser-Thr/Tyr_kinase | UniProtKB/Swiss-Prot | |
| SH2 | UniProtKB/Swiss-Prot | |
| SH3_domain | UniProtKB/Swiss-Prot | |
| Tyr_kinase_AS | UniProtKB/Swiss-Prot | |
| Tyr_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00471744 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:79113 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:72428 | IMAGE-MGC_LOAD |
| Pfam | Pkinase_Tyr | UniProtKB/Swiss-Prot |
| SH2 | UniProtKB/Swiss-Prot | |
| SH3_1 | UniProtKB/Swiss-Prot | |
| PRINTS | SH2DOMAIN | UniProtKB/Swiss-Prot |
| SH3DOMAIN | UniProtKB/Swiss-Prot | |
| TYRKINASE | UniProtKB/Swiss-Prot | |
| PROSITE | PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_TYR | UniProtKB/Swiss-Prot | |
| SH2 | UniProtKB/Swiss-Prot | |
| SH3 | UniProtKB/Swiss-Prot | |
| SMART | SH2 | UniProtKB/Swiss-Prot |
| SH3 | UniProtKB/Swiss-Prot | |
| TyrKc | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| SH3 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.11309 | ENTREZGENE |
| UniProt | FGR_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-10-29 | Fgr | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Fgr | Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-01-20 | Fgr | Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog | FGR | Name updated | 10779 | APPROVED | |
| 2002-08-07 | Fgr | FGR | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Fgr | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 621319 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




