Fgr (FGR proto-oncogene, Src family tyrosine kinase) - Rat Genome Database

Send us a Message



Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Grant Resources Citing RGD About Us Contact Us
Search by Genomic Position Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quantitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Fgr (FGR proto-oncogene, Src family tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Fgr
Name: FGR proto-oncogene, Src family tyrosine kinase (Ensembl:FGR proto-onco, Src family tyrosine kinase)
RGD ID: 621319
Description: Enables protein tyrosine kinase activity. Involved in myoblast proliferation. Predicted to be located in cytoskeleton. Predicted to be active in plasma membrane. Predicted to colocalize with actin cytoskeleton and ruffle membrane. Orthologous to human FGR (FGR proto-oncogene, Src family tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; INTERACTS WITH (R)-noradrenaline; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: feline Gardner-Rasheed sarcoma viral oncogene; Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; p55-Fgr; proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase Fgr; tyrosine-protein kinase Fgr
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,473,767 - 150,503,524 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5150,473,792 - 150,503,169 (+)EnsemblGRCr8
mRatBN7.25145,189,814 - 145,219,571 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,189,841 - 145,217,326 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5147,889,803 - 147,917,343 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,659,399 - 149,686,941 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,647,808 - 149,675,309 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5150,092,214 - 150,119,717 (+)NCBI
Lyon_Normotensive5152,087,239 - 152,114,738 (+)NCBI
Lyon_Hypertensive5151,257,123 - 151,284,620 (+)NCBI
F344_StmMcwi5144,835,918 - 144,863,405 (+)NCBI
Rnor_6.05151,172,189 - 151,199,746 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,172,206 - 151,199,745 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.05154,839,086 - 154,866,424 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45152,119,455 - 152,147,057 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5143,612,003 - 143,639,441 (+)NCBICelera
RGSC_v3.15152,129,494 - 152,157,096 (-)NCBI
RH 3.4 Map5977.8RGD
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bosutinib  (EXP)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP,ISO)
chlorpromazine  (EXP)
cisplatin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
Dihydrocytochalasin B  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
endosulfan  (EXP,ISO)
fenofibrate  (EXP)
fentanyl  (EXP)
fructose  (ISO)
genistein  (ISO)
glucose  (ISO)
hypochlorous acid  (ISO)
imidacloprid  (ISO)
indometacin  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
metformin  (EXP)
methylarsonic acid  (ISO)
Moniliformin  (ISO)
Muraglitazar  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phosphatidic acid  (ISO)
ponatinib  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
tamibarotene  (ISO)
Tesaglitazar  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Hierarchical phosphorylation of a 50-kDa protein by protein tyrosine kinases TPK-IIB and C-Fgr, and its identification as HS1 hematopoietic-lineage cell-specific protein. Brunati AM, etal., Eur J Biochem. 1995 Apr 1;229(1):164-70.
2. Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr. Choi WS, etal., Mol Cell Biol 2004 Aug;24(16):6980-92.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6. Differential expression of protooncogenes related to transformation and cancer progression in rat myoblasts. Leibovitch SA, etal., Cancer Res. 1986 Aug;46(8):4097-103.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. The Src family kinases, Fgr, Fyn, Lck, and Lyn, colocalize with coated membranes in platelets. Stenberg PE, etal., Blood. 1997 Apr 1;89(7):2384-93.
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:2181286   PMID:7519620   PMID:8125254   PMID:8327512   PMID:8402898   PMID:8603737   PMID:10739672   PMID:10861086   PMID:11672534   PMID:11744621   PMID:15561106   PMID:16439675  
PMID:16921024   PMID:16964445   PMID:20458337   PMID:20624904   PMID:21746961   PMID:22871113   PMID:30352950  


Genomics

Comparative Map Data
Fgr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,473,767 - 150,503,524 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5150,473,792 - 150,503,169 (+)EnsemblGRCr8
mRatBN7.25145,189,814 - 145,219,571 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,189,841 - 145,217,326 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5147,889,803 - 147,917,343 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,659,399 - 149,686,941 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,647,808 - 149,675,309 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5150,092,214 - 150,119,717 (+)NCBI
Lyon_Normotensive5152,087,239 - 152,114,738 (+)NCBI
Lyon_Hypertensive5151,257,123 - 151,284,620 (+)NCBI
F344_StmMcwi5144,835,918 - 144,863,405 (+)NCBI
Rnor_6.05151,172,189 - 151,199,746 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,172,206 - 151,199,745 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.05154,839,086 - 154,866,424 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45152,119,455 - 152,147,057 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5143,612,003 - 143,639,441 (+)NCBICelera
RGSC_v3.15152,129,494 - 152,157,096 (-)NCBI
RH 3.4 Map5977.8RGD
Cytogenetic Map5q36NCBI
FGR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,612,064 - 27,635,185 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,611,388 - 27,635,565 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37127,938,575 - 27,961,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,811,387 - 27,834,314 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34127,622,952 - 27,634,715NCBI
Celera126,334,465 - 26,357,390 (-)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef126,195,016 - 26,217,930 (-)NCBIHuRef
CHM1_1128,054,060 - 28,076,993 (-)NCBICHM1_1
T2T-CHM13v2.0127,453,366 - 27,476,486 (-)NCBIT2T-CHM13v2.0
Fgr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,701,406 - 132,729,204 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,701,257 - 132,730,053 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384132,974,095 - 133,001,893 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,974,095 - 133,001,910 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv374132,530,010 - 132,557,808 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364132,246,204 - 132,273,882 (+)NCBIMGSCv36mm8
Celera4131,136,566 - 131,164,622 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.11NCBI
Fgr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,841,802 - 6,863,542 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554526,840,274 - 6,863,460 (-)NCBIChiLan1.0ChiLan1.0
FGR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21199,218,002 - 199,240,963 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11198,334,434 - 198,358,178 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,872,781 - 26,895,751 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,918,758 - 27,941,678 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,918,758 - 27,941,678 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
FGR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,678,858 - 72,692,417 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,680,675 - 72,690,251 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha269,248,647 - 69,270,097 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0273,232,619 - 73,254,079 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,240,640 - 73,251,913 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1270,059,023 - 70,080,473 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,070,351 - 71,091,778 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,066,735 - 72,088,165 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fgr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11118,828,797 - 18,850,935 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_02440505846,072,309 - 46,094,439 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647411,896,914 - 11,919,190 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647411,897,998 - 11,919,153 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,809,542 - 84,830,361 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1684,809,534 - 84,830,401 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2678,326,176 - 78,358,345 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap120109,455,533 - 109,479,191 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366603311,285,735 - 11,309,416 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.120105,155,223 - 105,178,813 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20105,165,043 - 105,179,067 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Fgr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476411,482,719 - 11,513,215 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462476411,489,685 - 11,513,270 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl722,807,490 - 22,818,637 (+)Ensembl
Fgr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1125,234,016 - 25,250,897 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Fgr
303 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:331
Count of miRNA genes:195
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000013778
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Got83  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25145,205,556 - 145,205,750 (+)MAPPERmRatBN7.2
Rnor_6.05151,187,978 - 151,188,171NCBIRnor6.0
Rnor_5.05154,854,649 - 154,854,842UniSTSRnor5.0
RGSC_v3.45152,131,030 - 152,131,224RGDRGSC3.4
RGSC_v3.45152,131,031 - 152,131,224UniSTSRGSC3.4
Celera5143,627,672 - 143,627,865UniSTS
RGSC_v3.15152,141,070 - 152,141,263RGD
RH 3.4 Map5989.2RGD
RH 3.4 Map5989.2UniSTS
Cytogenetic Map5q36UniSTS
RH142441  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25145,216,800 - 145,216,950 (+)MAPPERmRatBN7.2
Rnor_6.05151,199,220 - 151,199,369NCBIRnor6.0
Rnor_5.05154,865,891 - 154,866,040UniSTSRnor5.0
RGSC_v3.45152,119,832 - 152,119,981UniSTSRGSC3.4
Celera5143,638,915 - 143,639,064UniSTS
RH 3.4 Map5977.8UniSTS
Cytogenetic Map5q36UniSTS
RH141155  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25145,216,742 - 145,216,933 (+)MAPPERmRatBN7.2
Rnor_6.05151,199,162 - 151,199,352NCBIRnor6.0
Rnor_5.05154,865,833 - 154,866,023UniSTSRnor5.0
RGSC_v3.45152,119,849 - 152,120,039UniSTSRGSC3.4
Celera5143,638,857 - 143,639,047UniSTS
RH 3.4 Map5977.8UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
275 156 722 1576 3985 1003 1722 126 868 496 850 156 5353 2582 449 3890 38 1378 730 909 154 152

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063288461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC062025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X57018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000013778   ⟹   ENSRNOP00000013779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5150,473,792 - 150,503,169 (+)Ensembl
mRatBN7.2 Ensembl5145,189,841 - 145,217,326 (+)Ensembl
Rnor_6.0 Ensembl5151,172,206 - 151,199,745 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085674   ⟹   ENSRNOP00000075272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5151,181,559 - 151,199,500 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126557   ⟹   ENSRNOP00000108194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5150,473,792 - 150,503,169 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000127646   ⟹   ENSRNOP00000101725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5150,483,640 - 150,503,169 (+)Ensembl
RefSeq Acc Id: NM_024145   ⟹   NP_077059
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,473,797 - 150,501,280 (+)NCBI
mRatBN7.25145,189,841 - 145,217,327 (+)NCBI
Dahl_SR_JrHsd5150,092,214 - 150,119,717 (+)NCBI
Lyon_Normotensive5152,087,239 - 152,114,738 (+)NCBI
Lyon_Hypertensive5151,257,123 - 151,284,620 (+)NCBI
F344_StmMcwi5144,835,918 - 144,863,405 (+)NCBI
Rnor_6.05151,172,206 - 151,199,746 (+)NCBI
Rnor_5.05154,839,086 - 154,866,424 (+)NCBI
RGSC_v3.45152,119,455 - 152,147,057 (-)RGD
Celera5143,612,003 - 143,639,441 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239079   ⟹   XP_006239141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,483,526 - 150,503,524 (+)NCBI
mRatBN7.25145,199,571 - 145,216,655 (+)NCBI
Rnor_6.05151,181,962 - 151,199,746 (+)NCBI
Rnor_5.05154,839,086 - 154,866,424 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239080   ⟹   XP_006239142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,473,767 - 150,503,524 (+)NCBI
mRatBN7.25145,189,815 - 145,216,655 (+)NCBI
Rnor_6.05151,172,189 - 151,199,746 (+)NCBI
Rnor_5.05154,839,086 - 154,866,424 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239081   ⟹   XP_006239143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,473,773 - 150,503,524 (+)NCBI
mRatBN7.25145,189,819 - 145,216,655 (+)NCBI
Rnor_6.05151,172,189 - 151,199,746 (+)NCBI
Rnor_5.05154,839,086 - 154,866,424 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239082   ⟹   XP_006239144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,473,773 - 150,503,524 (+)NCBI
mRatBN7.25145,189,819 - 145,216,655 (+)NCBI
Rnor_6.05151,172,189 - 151,199,746 (+)NCBI
Rnor_5.05154,839,086 - 154,866,424 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110824   ⟹   XP_038966752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,483,521 - 150,503,524 (+)NCBI
mRatBN7.25145,199,567 - 145,219,571 (+)NCBI
RefSeq Acc Id: XM_039110825   ⟹   XP_038966753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,481,353 - 150,503,524 (+)NCBI
mRatBN7.25145,197,402 - 145,217,076 (+)NCBI
RefSeq Acc Id: XM_039110826   ⟹   XP_038966754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,473,767 - 150,503,524 (+)NCBI
mRatBN7.25145,189,814 - 145,216,655 (+)NCBI
RefSeq Acc Id: XM_039110827   ⟹   XP_038966755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,483,526 - 150,503,524 (+)NCBI
mRatBN7.25145,199,571 - 145,216,655 (+)NCBI
RefSeq Acc Id: XM_039110829   ⟹   XP_038966757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,473,797 - 150,503,524 (+)NCBI
mRatBN7.25145,189,848 - 145,216,655 (+)NCBI
RefSeq Acc Id: XM_063288461   ⟹   XP_063144531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,483,705 - 150,503,524 (+)NCBI
RefSeq Acc Id: NP_077059   ⟸   NM_024145
- UniProtKB: Q63206 (UniProtKB/Swiss-Prot),   Q6P6U0 (UniProtKB/Swiss-Prot),   A0ABK0LC17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239143   ⟸   XM_006239081
- Peptide Label: isoform X1
- UniProtKB: Q63206 (UniProtKB/Swiss-Prot),   Q6P6U0 (UniProtKB/Swiss-Prot),   A0ABK0LC17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239144   ⟸   XM_006239082
- Peptide Label: isoform X1
- UniProtKB: Q63206 (UniProtKB/Swiss-Prot),   Q6P6U0 (UniProtKB/Swiss-Prot),   A0ABK0LC17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239142   ⟸   XM_006239080
- Peptide Label: isoform X1
- UniProtKB: Q63206 (UniProtKB/Swiss-Prot),   Q6P6U0 (UniProtKB/Swiss-Prot),   A0ABK0LC17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239141   ⟸   XM_006239079
- Peptide Label: isoform X1
- UniProtKB: Q63206 (UniProtKB/Swiss-Prot),   Q6P6U0 (UniProtKB/Swiss-Prot),   A0ABK0LC17 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075272   ⟸   ENSRNOT00000085674
Ensembl Acc Id: ENSRNOP00000013779   ⟸   ENSRNOT00000013778
RefSeq Acc Id: XP_038966754   ⟸   XM_039110826
- Peptide Label: isoform X1
- UniProtKB: Q6P6U0 (UniProtKB/Swiss-Prot),   Q63206 (UniProtKB/Swiss-Prot),   A0ABK0LC17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966757   ⟸   XM_039110829
- Peptide Label: isoform X1
- UniProtKB: Q6P6U0 (UniProtKB/Swiss-Prot),   Q63206 (UniProtKB/Swiss-Prot),   A0ABK0LC17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966753   ⟸   XM_039110825
- Peptide Label: isoform X1
- UniProtKB: Q6P6U0 (UniProtKB/Swiss-Prot),   Q63206 (UniProtKB/Swiss-Prot),   A0ABK0LC17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966752   ⟸   XM_039110824
- Peptide Label: isoform X1
- UniProtKB: Q6P6U0 (UniProtKB/Swiss-Prot),   Q63206 (UniProtKB/Swiss-Prot),   A0ABK0LC17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966755   ⟸   XM_039110827
- Peptide Label: isoform X1
- UniProtKB: Q6P6U0 (UniProtKB/Swiss-Prot),   Q63206 (UniProtKB/Swiss-Prot),   A0ABK0LC17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144531   ⟸   XM_063288461
- Peptide Label: isoform X1
- UniProtKB: Q6P6U0 (UniProtKB/Swiss-Prot),   Q63206 (UniProtKB/Swiss-Prot),   A0ABK0LC17 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101725   ⟸   ENSRNOT00000127646
Ensembl Acc Id: ENSRNOP00000108194   ⟸   ENSRNOT00000126557
Protein Domains
Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6U0-F1-model_v2 AlphaFold Q6P6U0 1-517 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694108
Promoter ID:EPDNEW_R4631
Type:single initiation site
Name:Fgr_1
Description:FGR proto-oncogene, Src family tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05151,172,228 - 151,172,288EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621319 AgrOrtholog
BioCyc Gene G2FUF-39648 BioCyc
Ensembl Genes ENSRNOG00000009912 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055024231 UniProtKB/Swiss-Prot
  ENSRNOG00060027348 UniProtKB/Swiss-Prot
  ENSRNOG00065028857 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013778 ENTREZGENE
  ENSRNOT00000013778.7 UniProtKB/Swiss-Prot
  ENSRNOT00000126557 ENTREZGENE
  ENSRNOT00000127646 ENTREZGENE
  ENSRNOT00055041597 UniProtKB/Swiss-Prot
  ENSRNOT00060047477 UniProtKB/Swiss-Prot
  ENSRNOT00065049807 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623501 IMAGE-MGC_LOAD
InterPro Fgr_SH2 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Non-receptor_tyrosine_kinases UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:79113 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72428 IMAGE-MGC_LOAD
NCBI Gene 79113 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Fgr PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009912 RatGTEx
  ENSRNOG00055024231 RatGTEx
  ENSRNOG00060027348 RatGTEx
  ENSRNOG00065028857 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0ABK0LC17 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LJH3_RAT UniProtKB/TrEMBL
  FGR_RAT UniProtKB/Swiss-Prot
  Q63206 ENTREZGENE
  Q6P6U0 ENTREZGENE
UniProt Secondary Q63206 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-23 Fgr  FGR proto-oncogene, Src family tyrosine kinase  Fgr  feline Gardner-Rasheed sarcoma viral oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-18 Fgr  feline Gardner-Rasheed sarcoma viral oncogene  Fgr  Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-29 Fgr  Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog  Fgr  Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Fgr  Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog    FGR  Name updated 1299863 APPROVED
2002-08-07 Fgr  FGR      Symbol and Name status set to provisional 70820 PROVISIONAL