Spmip11 (sperm microtubule inner protein 11) - Rat Genome Database

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Gene: Spmip11 (sperm microtubule inner protein 11) Rattus norvegicus
Analyze
Symbol: Spmip11 (Ensembl: Tex49)
Name: sperm microtubule inner protein 11 (Ensembl:testis expressed 49)
RGD ID: 1305928
Description: Predicted to be active in axonemal A tubule inner sheath. Orthologous to human SPMIP11 (sperm microtubule inner protein 11); INTERACTS WITH 1,3-dinitrobenzene; bexarotene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical LOC300207; hypothetical protein LOC300207; LOC300207; RGD1305928; testis expressed 49; testis-expressed protein 49; Tex49; uncharacterized protein LOC300207
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,599,977 - 131,621,508 (+)NCBIGRCr8
mRatBN7.27129,720,950 - 129,742,485 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,720,950 - 129,742,485 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,528,309 - 131,549,840 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,753,859 - 133,775,390 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,666,359 - 133,687,892 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,248,852 - 140,270,340 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,248,852 - 140,270,340 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,753,032 - 114,774,038 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,317,938 - 137,339,581 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17137,411,388 - 137,416,021 (+)NCBI
Celera7126,211,764 - 126,233,103 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Spmip11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,599,977 - 131,621,508 (+)NCBIGRCr8
mRatBN7.27129,720,950 - 129,742,485 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,720,950 - 129,742,485 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,528,309 - 131,549,840 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,753,859 - 133,775,390 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,666,359 - 133,687,892 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07140,248,852 - 140,270,340 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7140,248,852 - 140,270,340 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,753,032 - 114,774,038 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,317,938 - 137,339,581 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17137,411,388 - 137,416,021 (+)NCBI
Celera7126,211,764 - 126,233,103 (+)NCBICelera
Cytogenetic Map7q36NCBI
SPMIP11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,727,435 - 48,771,459 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1248,727,435 - 48,765,790 (+)EnsemblGRCh38hg38GRCh38
GRCh371249,121,218 - 49,159,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,407,491 - 47,445,836 (+)NCBINCBI36Build 36hg18NCBI36
Celera1247,917,215 - 47,955,479 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1246,155,300 - 46,193,000 (+)NCBIHuRef
CHM1_11249,087,058 - 49,125,401 (+)NCBICHM1_1
T2T-CHM13v2.01248,689,465 - 48,733,487 (+)NCBIT2T-CHM13v2.0
Spmip11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,468,885 - 98,487,469 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,468,885 - 98,487,461 (+)EnsemblGRCm39 Ensembl
GRCm381598,571,004 - 98,589,588 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,571,004 - 98,589,580 (+)EnsemblGRCm38mm10GRCm38
MGSCv371598,401,435 - 98,420,015 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361598,399,038 - 98,417,622 (+)NCBIMGSCv36mm8
Celera15100,718,199 - 100,737,191 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.57NCBI
SPMIP11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21045,414,896 - 45,454,774 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11245,411,656 - 45,451,534 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01239,981,453 - 40,019,769 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11240,859,532 - 40,898,153 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,859,532 - 40,898,153 (-)Ensemblpanpan1.1panPan2
SPMIP11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,755,150 - 5,779,674 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,755,150 - 5,779,617 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,478,143 - 40,502,744 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0275,806,051 - 5,830,880 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,806,112 - 5,830,823 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,769,854 - 5,794,419 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,759,910 - 5,784,716 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02740,870,180 - 40,894,998 (+)NCBIUU_Cfam_GSD_1.0
Spmip11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,552,500 - 66,576,796 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365126,592,454 - 6,612,169 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SPMIP11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666037201,140,650 - 201,151,004 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Spmip11
103 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
BE111737  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27129,719,208 - 129,719,378 (+)MAPPERmRatBN7.2
Rnor_6.07140,247,112 - 140,247,281NCBIRnor6.0
Rnor_5.0X114,751,292 - 114,751,461UniSTSRnor5.0
RGSC_v3.47137,316,198 - 137,316,367UniSTSRGSC3.4
Celera7126,210,024 - 126,210,193UniSTS
RH 3.4 Map71077.7UniSTS
Cytogenetic Map7q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 2 7
Low 1 15 34 18 17 18 3 4 9 23 8 11 3
Below cutoff 8 15 15 2 15 4 6 44 10 20 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087338   ⟹   ENSRNOP00000070885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7129,720,950 - 129,742,485 (+)Ensembl
Rnor_6.0 Ensembl7140,248,852 - 140,270,340 (+)Ensembl
RefSeq Acc Id: NM_001134528   ⟹   NP_001128000
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,599,977 - 131,621,508 (+)NCBI
mRatBN7.27129,720,950 - 129,742,485 (+)NCBI
Rnor_6.07140,248,852 - 140,270,340 (+)NCBI
Rnor_5.0X114,753,032 - 114,774,038 (+)NCBI
RGSC_v3.47137,317,938 - 137,339,581 (+)RGD
Celera7126,211,764 - 126,233,103 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128000 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87052 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070885
  ENSRNOP00000070885.1
Reference Protein Sequences
RefSeq Acc Id: NP_001128000   ⟸   NM_001134528
- UniProtKB: D3ZMG5 (UniProtKB/TrEMBL),   A6KC90 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070885   ⟸   ENSRNOT00000087338

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMG5-F1-model_v2 AlphaFold D3ZMG5 1-131 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695625
Promoter ID:EPDNEW_R6150
Type:single initiation site
Name:Tex49_1
Description:testis expressed 49
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07140,248,853 - 140,248,913EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305928 AgrOrtholog
BioCyc Gene G2FUF-32127 BioCyc
Ensembl Genes ENSRNOG00000057264 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087338 ENTREZGENE
  ENSRNOT00000087338.2 UniProtKB/TrEMBL
InterPro TEX49 UniProtKB/TrEMBL
KEGG Report rno:300207 UniProtKB/TrEMBL
NCBI Gene 300207 ENTREZGENE
PANTHER PTHR35263 UniProtKB/TrEMBL
  TESTIS-EXPRESSED PROTEIN 49 UniProtKB/TrEMBL
PhenoGen Spmip11 PhenoGen
RatGTEx ENSRNOG00000057264 RatGTEx
UniProt A6KC90 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMG5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-05 Spmip11  sperm microtubule inner protein 11  Tex49  testis expressed 49  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-09-26 Tex49  testis expressed 49  RGD1305928  hypothetical LOC300207  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1305928  hypothetical LOC300207   RGD1305928_predicted  hypothetical LOC300207 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1305928_predicted  hypothetical LOC300207 (predicted)  LOC300207_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC300207_predicted  hypothetical LOC300207 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL