Gene: Ddx18 (DEAD-box helicase 18) Rattus norvegicus

Analyze

Symbol:

Ddx18

Name:

DEAD-box helicase 18

RGD ID:

1549712

Description:

Predicted to enable ATP binding activity; RNA binding activity; and RNA helicase activity. Involved in cellular response to estradiol stimulus. Predicted to be located in chromosome and nucleolus. Orthologous to human DDX18 (DEAD-box helicase 18); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ATP-dependent RNA helicase DDX18; DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; MGC95311; MrDb; Myc-regulated DEAD box protein; similar to RIKEN cDNA 2310005B10

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DDX18 (DEAD-box helicase 18)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ddx18 (DEAD box helicase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ddx18 (DEAD-box helicase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DDX18 (DEAD-box helicase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DDX18 (DEAD-box helicase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ddx18 (DEAD-box helicase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DDX18 (DEAD-box helicase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DDX18 (DEAD-box helicase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ddx18 (DEAD-box helicase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ddx18 (DEAD-box helicase 18)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RILPL2 (Rab interacting lysosomal protein like 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	DDX18 (DEAD-box helicase 18)	Alliance	DIOPT (HGNC)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	35,282,391 - 35,296,038 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	35,282,467 - 35,295,972 (-)	Ensembl				GRCr8
mRatBN7.2	13	32,729,697 - 32,743,161 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	32,729,700 - 32,743,161 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	35,292,118 - 35,305,666 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	36,580,015 - 36,593,563 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	33,854,534 - 33,868,075 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	13	34,659,631 - 34,673,184 (-)	NCBI
Lyon_Normotensive	13	34,853,717 - 34,867,270 (-)	NCBI
Lyon_Hypertensive	13	34,841,018 - 34,854,571 (-)	NCBI
F344_StmMcwi	13	34,759,041 - 34,772,591 (-)	NCBI
Rnor_6.0	13	37,522,558 - 37,536,066 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	37,522,561 - 37,536,066 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	13	42,680,394 - 42,693,902 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	33,587,928 - 33,601,436 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	32,594,103 - 32,607,613 (-)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

Breast Cancer, Familial (ISO)

cervical cancer (ISO)

clear cell renal cell carcinoma (ISO)

esophageal cancer (ISO)

head and neck squamous cell carcinoma (ISO)

hepatocellular carcinoma (ISO)

lung cancer (ISO)

lung squamous cell carcinoma (ISO)

nonpapillary renal cell carcinoma (ISO)

ovarian serous cystadenocarcinoma (ISO)

stomach cancer (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

uterine corpus endometrial carcinoma (ISO)

uveal melanoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,6-tribromophenol (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

acetylsalicylic acid (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

atrazine (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

caffeine (ISO)

cannabidiol (ISO)

CGP 52608 (ISO)

chloroprene (EXP)

cisplatin (ISO)

cyclosporin A (ISO)

DDE (ISO)

decabromodiphenyl ether (ISO)

deoxynivalenol (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

disodium selenite (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

ethyl methanesulfonate (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

ivermectin (ISO)

LDN-193189 (ISO)

methyl methanesulfonate (ISO)

nitrates (ISO)

Nivalenol (ISO)

paracetamol (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

tamibarotene (ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiophenes (ISO)

titanium dioxide (ISO)

tolcapone (EXP)

triphenyl phosphate (ISO)

tungsten (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to estradiol stimulus (IEP)

Cellular Component

chromosome (ISO)

nucleolus (ISO)

Molecular Function

ATP binding (IEA)

hydrolase activity (IEA)

nucleic acid binding (IEA)

nucleotide binding (IEA)

RNA binding (IEA)

RNA helicase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ribosome biogenesis pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo.	Grandori C, etal., EMBO J. 1996 Aug 15;15(16):4344-57.
3.	DExD/H-box RNA helicases in ribosome biogenesis.	Martin R, etal., RNA Biol. 2013 Jan;10(1):4-18. doi: 10.4161/rna.21879. Epub 2012 Aug 24.
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation
8.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:16963496	PMID:19946888	PMID:20813266	PMID:22658674	PMID:22681889

Genomics

Comparative Map Data

Ddx18
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	35,282,391 - 35,296,038 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	35,282,467 - 35,295,972 (-)	Ensembl				GRCr8
mRatBN7.2	13	32,729,697 - 32,743,161 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	32,729,700 - 32,743,161 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	35,292,118 - 35,305,666 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	36,580,015 - 36,593,563 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	33,854,534 - 33,868,075 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	13	34,659,631 - 34,673,184 (-)	NCBI
Lyon_Normotensive	13	34,853,717 - 34,867,270 (-)	NCBI
Lyon_Hypertensive	13	34,841,018 - 34,854,571 (-)	NCBI
F344_StmMcwi	13	34,759,041 - 34,772,591 (-)	NCBI
Rnor_6.0	13	37,522,558 - 37,536,066 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	37,522,561 - 37,536,066 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	13	42,680,394 - 42,693,902 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	33,587,928 - 33,601,436 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	32,594,103 - 32,607,613 (-)	NCBI		Celera
Cytogenetic Map	13	q11	NCBI

DDX18
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	117,814,691 - 117,832,377 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	117,814,656 - 117,832,716 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	2	118,572,267 - 118,589,953 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	118,288,725 - 118,306,423 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	118,288,484 - 118,306,183	NCBI
Celera	2	111,899,413 - 111,917,115 (+)	NCBI		Celera
Cytogenetic Map	2	q14.1	NCBI
HuRef	2	110,899,351 - 110,917,048 (+)	NCBI		HuRef
CHM1_1	2	118,576,084 - 118,593,783 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	118,247,963 - 118,265,651 (+)	NCBI		T2T-CHM13v2.0

Ddx18
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	121,481,564 - 121,495,709 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	121,481,564 - 121,495,718 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	121,553,835 - 121,567,980 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	121,553,835 - 121,567,989 (-)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	1	123,450,412 - 123,464,557 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	123,381,385 - 123,395,474 (-)	NCBI		MGSCv36	mm8
Celera	1	124,194,901 - 124,209,051 (-)	NCBI		Celera
Cytogenetic Map	1	E2.3	NCBI
cM Map	1	52.98	NCBI

Ddx18
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955459	11,800,684 - 11,810,876 (-)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955459	11,799,435 - 11,810,973 (-)	NCBI	ChiLan1.0	ChiLan1.0

DDX18
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	19,840,884 - 19,858,690 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	19,855,856 - 19,873,662 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	4,772,668 - 4,790,366 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	118,358,168 - 118,375,908 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	118,358,168 - 118,375,910 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

DDX18
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	32,014,586 - 32,030,634 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	32,015,512 - 32,030,602 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	32,282,705 - 32,298,733 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	33,407,420 - 33,423,471 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	33,407,427 - 33,423,422 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	32,083,578 - 32,099,618 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	32,253,818 - 32,270,107 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	33,443,099 - 33,459,140 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ddx18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	7	96,250,929 - 96,265,862 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024405303	89,243,288 - 89,258,094 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	52,361,081 - 52,374,358 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	52,359,653 - 52,374,471 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DDX18
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	23,425,669 - 23,442,980 (+)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	15	23,425,674 - 23,442,985 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	26,805,698 - 26,823,004 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DDX18
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	10	13,714,449 - 13,732,261 (-)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666061	10,151,103 - 10,168,776 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	10	12,455,877 - 12,473,670 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	12,457,543 - 12,473,655 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Ddx18
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624732	27,416,851 - 27,432,397 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
Naked mole-rat maternal Ensembl	3	61,285,941 - 61,300,945 (+)	Ensembl

Ddx18
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	14,143,619 - 14,157,220 (-)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Variants

Variants in Ddx18
219 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	30
Count of miRNA genes:	30
Interacting mature miRNAs:	30
Transcripts:	ENSRNOT00000037203
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	24853925	69853925	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	12448421	47969993	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2303030	Bp327	Blood pressure QTL 327			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	43736554	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	6002008	47359539	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	24335432	55601132	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	12448421	48744906	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	26244808	71244808	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	33794096	60914504	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	3088755	48088755	Rat
631672	Iddm12	Insulin dependent diabetes mellitus QTL 12	2.2	0.0032	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	6002008	37088115	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	26244808	71244808	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
275	156	728	1590	4034	1011	1726	133	874	494	856	156	5391	2594	444	3947	38	1391	731	907	160	158

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001006996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272408	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000037203 ⟹ ENSRNOP00000038728

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	35,282,467 - 35,295,972 (-)	Ensembl
mRatBN7.2 Ensembl	13	32,729,700 - 32,743,161 (-)	Ensembl
Rnor_6.0 Ensembl	13	37,522,561 - 37,536,066 (-)	Ensembl

RefSeq Acc Id:

NM_001006996 ⟹ NP_001006997

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	35,282,464 - 35,295,972 (-)	NCBI
mRatBN7.2	13	32,729,697 - 32,743,161 (-)	NCBI
Dahl_SR_JrHsd	13	34,659,631 - 34,673,184 (-)	NCBI
Lyon_Normotensive	13	34,853,717 - 34,867,270 (-)	NCBI
Lyon_Hypertensive	13	34,841,018 - 34,854,571 (-)	NCBI
F344_StmMcwi	13	34,759,041 - 34,772,591 (-)	NCBI
Rnor_6.0	13	37,522,558 - 37,536,066 (-)	NCBI
Rnor_5.0	13	42,680,394 - 42,693,902 (-)	NCBI
RGSC_v3.4	13	33,587,928 - 33,601,436 (-)	RGD
Celera	13	32,594,103 - 32,607,613 (-)	RGD

Sequence:

show sequence

CGCTCGGTGCAGACGGCTGGGCAACCCGGCAACATGTCGCAGTTACAGATGAAACTCCTGCGCA
AGAAGATCGAAAAGCGGAACGCCAAGCTGCGGCAACGGAACCTGAAGCTGCAAGAAGCATCAGA
CAGGAGCCTGTCACAGCCTGAAAATGGAGATGTGCCTGAAGAACTAGGAAAAGGTGGAAAAGCT
AAAAAGGCCCTGAAGCATTCTGTGACTGCAGGCTCAGCAGAAGCACAAAGTAGAGGCGTGCCCG
AGGAGACTGTGGAAAATGCCAAAGTTAAAAAGTCACCCCAAAAACTTACCATTTTAACCAATGG
AGAAGCAGCAGCAATGCCATCTACAGATCCAGAACTAAAGAAGAAAAAGAAGAAGAAGAGGAAA
ATTGGAAATGACACTGAGCCTGATCCCAAAAAAGCAAAAACTGAAGAAGGCACGGAGGCTCGTG
AGGAACCAGAAGGGGCTGGTGAGGAACCAGAAGGGGCTGGTGAGGAACCAGAAGATGGTGTGAA
GGAGGCAGATGACAGTGAGGTGCCCAGTCTGCCGTTGGGAGTGACAGGTGCTTTCGAGGACACT
TCGTTTGCTTCCTTGTCTAATCTCGTCAATGAGAACACCCTGAAGGCCATAGAAGAAATGGGCT
TCAAGCACATGACAGAGATCCAGCATAAAAGTATCAGGCCACTTCTGGAAGGCAGGGATCTTCT
GGCGGCTGCGAAAACCGGCAGCGGCAAGACCCTTGCTTTCCTCATCCCTGTGATCGAGCTCATT
GTCAAATTGAAGTTCATGCCCAGGAATGGAACAGGAGTCCTGATTCTCTCTCCTACCAGAGAAC
TGGCCATGCAGACCTTTGGTGTGCTTAAGGAACTGATGACACACCACGTTCACACGTACGGGCT
GATCATGGGTGGCAGTAACAGGTCTGCTGAGGTACAGAAGCTTCTCAATGGGATCAACATCGTC
GTGGCCACCCCAGGCCGGCTCCTAGACCACATGCAGAACACACCAGGGTTTATGTACAAGAACC
TGCAGTGTCTGGTTATCGATGAGGCCGACCGTATCTTGGATGTTGGGTTTGAAGAAGAATTAAA
GCAGATCATTAAACTTTTGCCAGCACGTAGGCAAACCATGCTCTTCTCTGCCACACAAACTCGA
AAAGTTGAAGACTTGGCAAGAATTTCCCTGAAAAAAGAGCCATTGTACGTGGGTGTTGACGACG
ACAAAGAGGTTGCCACAGTGGATGGCCTTGAGCAGGGGTATGTTGTCTGTCCCTCTGAGAAGAG
GTTCCTTCTGCTTTTCACATTCCTTAAGAAGAACCGGAAGAAGAAAGTGATGGTCTTCTTTTCC
TCCTGTATGTCTGTGAAATACCACTATGAGCTGCTGAACTACATTGACCTGCCTGTCTTAGCCA
TCCATGGAAAGCAAAAGCAAAATAAGCGAACAACCACGTTCTTCCAATTCTGCAACGCAGATTC
GGGAATACTGCTGTGCACTGATGTGGCGGCCAGAGGGCTGGACATCCCTGAAGTGGACTGGATT
GTTCAGTACGATCCTCCCGATGACCCCAAGGAGTACATTCATCGGGTCGGCAGAACAGCCCGAG
GCCTGAATGGAAGAGGGCACGCCCTGCTCATCTTGCGCCCTGAAGAGCTGGGTTTCCTTCGGTA
CTTGAAACAATCCAAGGTTCCGTTGAATCAGTTTGACTTCTCCTGGTCTAAGGTTTCTGATATT
CAGTCTCAGCTGGAAAAACTGATCGAAAAGAACTACTTTCTGCACAAGTCTGCCCAGGAAGCGT
ACAAGTCCTACATACGGGCATATGACTCCCACTCTCTCAAGCAGATCTTCAATGTCAACAACTT
AAATTTGCCTCAAGTTGCTCTGTCTTTTGGTTTTAAGGTCCCTCCTTTTGTTGATCTGAATGTG
AGCAGCCACGACGGCAAGCTTAAAAAGAGAGGTGGTGGTGGGGGATTCGGCTACCAGAAAACAA
AGAAAGTGGAGAAGTCCAAGATCTTTAAACACATCAGTAAGAAGCCAGCAGACCGCAGGCAGTT
CTCTCACTGAGGCGATCTGCCTTCTGCCTGGACTGACTTTGCCCAACTTCCTCCTCCTCCACCC
CTGCTCCCCAGTACTCTTTAAAAAGGAACGTTTATCACAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAA

hide sequence

RefSeq Acc Id:

XM_063272408 ⟹ XP_063128478

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	35,282,391 - 35,296,038 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001006997	(Get FASTA)	NCBI Sequence Viewer
	XP_063128478	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83919	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000102608
	ENSRNOP00000102608.1

RefSeq Acc Id:

NP_001006997 ⟸ NM_001006996

- UniProtKB:

Q5XHY0 (UniProtKB/TrEMBL), A0ABK0LI45 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSQLQMKLLRKKIEKRNAKLRQRNLKLQEASDRSLSQPENGDVPEELGKGGKAKKALKHSVTAG
SAEAQSRGVPEETVENAKVKKSPQKLTILTNGEAAAMPSTDPELKKKKKKKRKIGNDTEPDPKK
AKTEEGTEAREEPEGAGEEPEGAGEEPEDGVKEADDSEVPSLPLGVTGAFEDTSFASLSNLVNE
NTLKAIEEMGFKHMTEIQHKSIRPLLEGRDLLAAAKTGSGKTLAFLIPVIELIVKLKFMPRNGT
GVLILSPTRELAMQTFGVLKELMTHHVHTYGLIMGGSNRSAEVQKLLNGINIVVATPGRLLDHM
QNTPGFMYKNLQCLVIDEADRILDVGFEEELKQIIKLLPARRQTMLFSATQTRKVEDLARISLK
KEPLYVGVDDDKEVATVDGLEQGYVVCPSEKRFLLLFTFLKKNRKKKVMVFFSSCMSVKYHYEL
LNYIDLPVLAIHGKQKQNKRTTTFFQFCNADSGILLCTDVAARGLDIPEVDWIVQYDPPDDPKE
YIHRVGRTARGLNGRGHALLILRPEELGFLRYLKQSKVPLNQFDFSWSKVSDIQSQLEKLIEKN
YFLHKSAQEAYKSYIRAYDSHSLKQIFNVNNLNLPQVALSFGFKVPPFVDLNVSSHDGKLKKRG
GGGGFGYQKTKKVEKSKIFKHISKKPADRRQFSH

hide sequence

Ensembl Acc Id:

ENSRNOP00000038728 ⟸ ENSRNOT00000037203

RefSeq Acc Id:	XP_063128478 ⟸ XM_063272408
- Peptide Label:	isoform X1

Protein Domains

Helicase ATP-binding Helicase C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5XHY0-F1-model_v2	AlphaFold	Q5XHY0	1-674	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698772

Promoter ID:

EPDNEW_R9296

Type:

initiation region

Name:

Ddx18_1

Description:

DEAD-box helicase 18

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	37,536,107 - 37,536,167	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1549712	AgrOrtholog
BioCyc Gene	G2FUF-18496	BioCyc
Ensembl Genes	ENSRNOG00000025430	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037203	ENTREZGENE
	ENSRNOT00000037203.5	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7135005	IMAGE-MGC_LOAD
InterPro	DDX18/Has1_DEADc	UniProtKB/TrEMBL
	DEAD-like_N	UniProtKB/TrEMBL
	DNA/RNA_helicase_C	UniProtKB/TrEMBL
	DNA/RNA_helicase_DEAD/DEAH_N	UniProtKB/TrEMBL
	DUF4217	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	RNA-helicase_DEAD-box_CS	UniProtKB/TrEMBL
KEGG Report	rno:308490	UniProtKB/TrEMBL
MGC_CLONE	MGC:95311	IMAGE-MGC_LOAD
NCBI Gene	308490	ENTREZGENE
PANTHER	RNA HELICASE	UniProtKB/TrEMBL
Pfam	DEAD	UniProtKB/TrEMBL
	DUF4217	UniProtKB/TrEMBL
	Helicase_C	UniProtKB/TrEMBL
PhenoGen	Ddx18	PhenoGen
PROSITE	DEAD_ATP_HELICASE	UniProtKB/TrEMBL
	HELICASE_ATP_BIND_1	UniProtKB/TrEMBL
	HELICASE_CTER	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000025430	RatGTEx
SMART	DEXDc	UniProtKB/TrEMBL
	DUF4217	UniProtKB/TrEMBL
	HELICc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0ABK0LI45	ENTREZGENE, UniProtKB/TrEMBL
	Q5XHY0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-13	Ddx18	DEAD-box helicase 18	Ddx18	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Ddx18	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	MGC95311	similar to RIKEN cDNA 2310005B10	Symbol and Name updated	1299863	APPROVED
2005-09-15	MGC95311	similar to RIKEN cDNA 2310005B10			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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