RIBOSOME BIOGENESIS PATHWAY (PW:0001066)

View Ontology Report

Description

The ribosome is involved in the final stage of gene expression thereby the genetic information is decoded into the protein polypeptide chain. In all organisms the ribosome is built of two subunits, each with distinct functions. The small eukaryotic 40S subunit (30S in prokaryotes) is the decoder that reads the mRNA while the large 60S subunit (50S in prokaryotes) carries out the catalytic peptidyl transferase reaction. The small 40s subunit is composed of one rRNA and 33 ribosomal proteins (RPS)

Pathway Diagram:

Elsevier Inc. Eif6 5S rRNA partners ITS1 cleavage/processing ---> pre-60S subunit box C/D 40S subunit ---- 60S subunit 80S ribosome translation pathway 60S subunit start codon scanning translation initiation pathway Mdn1 Gnl2 40S subunit ---> start codon scanning ribosomal proteins, large subunit ---> 60S subunit pre-60S subunit <--> 60S subunit pre-40S subunit ---> 40S subunit RNA helicases in ribosome biogenesis ribosomal proteins, large subunit large subunit maturation ribosomal proteins, small subunit small subnit maturation pre-60S subunit pre-40S subunit ITS1 cleavage/processing 5'-ETS cleavage/processing box H/ACA Nup88 Nup214 GTP Prkcb ---> Eif6 Prkcb ---| Eif6 pre-60S subunit ---- Xpo5 Nup214 ---- Xpo1 Nup214 ---- Nup88 Eri1 ribosomal proteins, small subunit ---> 40S subunit Gnl2 ---| Nmd3 ribosomal proteins, small subunit ---> pre-40S subunit ribosomal proteins, large subunit ---> pre-60S subunit box H/ACA ---> pre-60S subunit box C/D ---> pre-40S subunit box C/D ---> pre-60S subunit box H/ACA ---> pre-40S subunit 28S 5.8S ITS1 cleavage/processing ---> pre-40S subunit 5'-ETS cleavage/processing ---> pre-40S subunit RNA helicases in ribosome biogenesis ---> pre-40S subunit RNA helicases in ribosome biogenesis ---> pre-60S subunit Eri1 ---> 60S subunit Nob1 Nob1 ---> 40S subunit Prkcb RNA polymerase I transcription pathway RNA polymerase III transcription pathway Gnb2l1 Gnb2l1 ---- Prkcb 40S subunit ---- Gnb2l1 60S subunit ---- Eif6 5S ---> pre-60S subunit 5S 5S ---- 5S rRNA partners Ran Xpo5 Nmd3 ---- Xpo1 GTP ---- Ran Nmd3 5.8S ---> large subunit maturation 28S ---> large subunit maturation 18S 40S subunit Xpo1 Nmd3 ---- pre-60S subunit Ltv1 ---- Xpo1 Ltv1 small subnit maturation ---> 40S subunit large subunit maturation ---> 60S subunit 18S ---> small subnit maturation Gnl2 ---- pre-60S subunit Mdn1 ---| Gnl2 Eif6 ---| 80S ribosome
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Genes in Pathway:

show annotations for term's descendants       view all columns
ribosome biogenesis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bms1 BMS1 ribosome biogenesis factor JBrowse link 4 150,433,567 150,471,783 RGD:6907045
RGD:9999445
G Bop1 block of proliferation 1 JBrowse link 7 117,514,529 117,538,342 RGD:9999448
RGD:9999449
G Bysl bystin-like JBrowse link 9 15,393,461 15,403,212 RGD:9999448
RGD:9999449
RGD:10002751
G C1d C1D nuclear receptor co-repressor JBrowse link 14 100,415,645 100,427,878 RGD:9999448
G Csnk1d casein kinase 1, delta JBrowse link 10 110,147,786 110,182,413 RGD:10002751
G Csnk1e casein kinase 1, epsilon JBrowse link 7 120,651,976 120,675,559 RGD:10002751
G Csnk2a1 casein kinase 2 alpha 1 JBrowse link 3 147,713,808 147,760,375 RGD:6907045
G Csnk2a2 casein kinase 2 alpha 2 JBrowse link 19 9,972,537 10,012,043 RGD:6907045
G Csnk2b casein kinase 2 beta JBrowse link 20 5,108,692 5,113,675 RGD:6907045
G Ddx10 DEAD-box helicase 10 JBrowse link 8 57,667,472 57,830,504 RGD:10002738
G Ddx18 DEAD-box helicase 18 JBrowse link 13 37,522,558 37,536,066 RGD:10002738
G Ddx24 DEAD-box helicase 24 JBrowse link 6 127,302,201 127,319,382 RGD:10002738
G Ddx56 DEAD-box helicase 56 JBrowse link 14 86,378,937 86,387,637 RGD:10002738
G Dhx15 DEAH-box helicase 15 JBrowse link 14 61,136,740 61,174,880 RGD:10002738
G Dhx37 DEAH-box helicase 37 JBrowse link 12 36,594,058 36,614,165 RGD:10002738
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease JBrowse link 15 83,466,330 83,494,107 RGD:9999448
G Dkc1 dyskerin pseudouridine synthase 1 JBrowse link X 155,844,914 155,862,363 RGD:6907045
RGD:9999451
G Efl1 elongation factor like GTPase 1 JBrowse link 1 144,601,425 144,740,634 RGD:6907045
G Eif6 eukaryotic translation initiation factor 6 JBrowse link 3 151,356,867 151,363,201 RGD:6907045
RGD:10002774
G Emg1 EMG1 N1-specific pseudouridine methyltransferase JBrowse link 4 157,222,366 157,230,647 RGD:6907045
G Eri1 exoribonuclease 1 JBrowse link 16 60,307,148 60,327,237 RGD:9999448
G Exosc10 exosome component 10 JBrowse link 5 165,374,964 165,398,195 RGD:9999445
G Exosc5 exosome component 5 JBrowse link 1 82,452,104 82,461,607 RGD:9999445
G Fau FAU, ubiquitin like and ribosomal protein S30 fusion JBrowse link 1 221,420,312 221,421,827 RGD:10002730
RGD:10002762
G Fbl fibrillarin JBrowse link 1 85,103,519 85,112,619 RGD:6907045
RGD:9999451
G Fbll1 fibrillarin-like 1 JBrowse link 10 20,620,957 20,622,600 RGD:6907045
G Fcf1 FCF1 rRNA-processing protein JBrowse link 6 108,796,182 108,808,051 RGD:9999445
G Gar1 GAR1 ribonucleoprotein JBrowse link 2 235,250,453 235,258,464 RGD:6907045
RGD:9999451
G Gnl2 G protein nucleolar 2 JBrowse link 5 143,027,970 143,053,418 RGD:6907045
RGD:10002740
G Gnl3 G protein nucleolar 3 JBrowse link 16 7,097,580 7,103,518 RGD:6907045
G Gnl3l G protein nucleolar 3 like JBrowse link X 20,037,558 20,070,505 RGD:6907045
G Gtpbp4 GTP binding protein 4 JBrowse link 17 63,111,086 63,145,618 RGD:6907045
G Heatr1 HEAT repeat containing 1 JBrowse link 17 66,446,135 66,488,303 RGD:6907045
G Imp3 IMP3, U3 small nucleolar ribonucleoprotein JBrowse link 8 61,607,021 61,607,909 RGD:6907045
RGD:9999445
G Imp4 IMP4, U3 small nucleolar ribonucleoprotein JBrowse link 9 37,769,959 37,775,097 RGD:6907045
RGD:9999445
G Lsg1 large 60S subunit nuclear export GTPase 1 JBrowse link 11 73,693,862 73,723,457 RGD:6907045
G Ltv1 LTV1 ribosome biogenesis factor JBrowse link 1 7,323,043 7,335,766 RGD:10002748
RGD:10002751
G Mdn1 midasin AAA ATPase 1 JBrowse link 5 47,894,526 48,036,071 RGD:6907045
RGD:10002739
G Mphosph10 M-phase phosphoprotein 10 JBrowse link 1 125,212,869 125,229,060 RGD:6907045
RGD:9999445
G Mpp6 membrane palmitoylated protein 6 JBrowse link 4 79,846,506 79,928,977 RGD:9999448
G Nhp2 NHP2 ribonucleoprotein JBrowse link 10 34,975,701 34,979,082 RGD:6907045
RGD:9999451
G Nmd3 NMD3 ribosome export adaptor JBrowse link 2 166,402,838 166,428,331 RGD:6907045
RGD:10002748
RGD:10002749
G Nob1 NIN1/PSMD8 binding protein 1 homolog JBrowse link 19 38,397,466 38,409,924 RGD:6907045
RGD:9999448
RGD:9999449
RGD:10002751
G Nol12 nucleolar protein 12 JBrowse link 7 120,161,238 120,166,852 RGD:9999448
RGD:9999449
G Nop10 NOP10 ribonucleoprotein JBrowse link 3 103,747,654 103,748,739 RGD:6907045
RGD:9999451
G Nop56 NOP56 ribonucleoprotein JBrowse link 3 122,803,726 122,808,564 RGD:6907045
RGD:9999451
G Nop58 NOP58 ribonucleoprotein JBrowse link 9 66,495,881 66,520,521 RGD:6907045
RGD:9999451
G Nup214 nucleoporin 214 JBrowse link 3
3
9,227,869
10,993,584
9,236,878
11,070,638
RGD:10002749
G Nup88 nucleoporin 88 JBrowse link 10 57,581,828 57,606,171 RGD:10002749
G Nvl nuclear VCP-like JBrowse link 13 99,410,026 99,468,783 RGD:6907045
G Nxf1 nuclear RNA export factor 1 JBrowse link 1 224,957,535 224,970,728 RGD:6907045
G Nxf3 nuclear RNA export factor 3 JBrowse link X 106,562,957 106,587,487 RGD:6907045
G Nxf7 nuclear RNA export factor 7 JBrowse link X 106,049,075 106,066,334 RGD:6907045
G Nxt1 nuclear transport factor 2-like export factor 1 JBrowse link 3 142,993,658 142,996,580 RGD:6907045
G Nxt2 nuclear transport factor 2-like export factor 2 JBrowse link X 113,509,841 113,517,112 RGD:6907045
G Pdcd11 programmed cell death 11 JBrowse link 1 266,866,931 266,908,042 RGD:9999449
G Pes1 pescadillo ribosomal biogenesis factor 1 JBrowse link 14 84,211,600 84,227,980 RGD:9999448
G Pno1 partner of NOB1 homolog JBrowse link 14 100,364,192 100,372,760 RGD:10002751
G Pop1 POP1 homolog, ribonuclease P/MRP subunit JBrowse link 7 73,270,403 73,298,209 RGD:6907045
G Pop4 POP4 homolog, ribonuclease P/MRP subunit JBrowse link 1 94,661,127 94,669,461 RGD:6907045
G Pop5 POP5 homolog, ribonuclease P/MRP subunit JBrowse link 12 47,138,346 47,143,152 RGD:6907045
G Pop7 POP7 homolog, ribonuclease P/MRP subunit JBrowse link 12 22,259,713 22,260,754 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:10002774
G Pwp2 PWP2, small subunit processome component JBrowse link 20 11,228,892 11,243,204 RGD:6907045
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:10002774
G Ran RAN, member RAS oncogene family JBrowse link 12 31,319,556 31,324,105 RGD:6907045
RGD:10002749
G Rasl2-9 RAS-like, family 2, locus 9 JBrowse link 1 72,272,032 72,273,210 RGD:6907045
G Rbm28 RNA binding motif protein 28 JBrowse link 4 56,398,769 56,438,442 RGD:6907045
RGD:9999449
G Rcl1 RNA terminal phosphate cyclase-like 1 JBrowse link 1 247,228,012 247,272,369 RGD:6907045
RGD:9999445
G Rexo1 RNA exonuclease 1 homolog JBrowse link 7 12,022,268 12,041,660 RGD:6907045
G Rexo1l1-ps1 REX1, RNA exonuclease 1 homolog-like 1, pseudogene 1 JBrowse link 2 143,830,019 143,832,825 RGD:6907045
G Rexo2 RNA exonuclease 2 JBrowse link 8 52,802,604 52,814,321 RGD:6907045
G Rexo5 RNA exonuclease 5 JBrowse link 1 189,549,960 189,643,698 RGD:6907045
G RGD1306195 similar to RAN protein JBrowse link 5 54,480,783 54,482,159 RGD:6907045
G RGD1566078 similar to NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (Sperm specific antigen 1) JBrowse link X 152,781,177 152,781,621 RGD:6907045
G Riok1 RIO kinase 1 JBrowse link 17 27,429,421 27,452,353 RGD:6907045
RGD:10002751
G Riok2 RIO kinase 2 JBrowse link 1 59,130,008 59,146,457 RGD:6907045
RGD:10002751
G Riok3 RIO kinase 3 JBrowse link 18 3,565,166 3,590,739 RGD:10002751
G Rpl10 ribosomal protein L10 JBrowse link X 156,438,251 156,440,461 RGD:10002762
G Rpl10a ribosomal protein L10A JBrowse link 20 7,908,309 7,910,867 RGD:10002762
G Rpl11 ribosomal protein L11 JBrowse link 5 154,390,809 154,394,412 RGD:10002762
G Rpl12 ribosomal protein L12 JBrowse link 3 12,009,578 12,011,952 RGD:10002762
G Rpl13 ribosomal protein L13 JBrowse link 19 55,917,489 55,920,040 RGD:10002762
G Rpl13a ribosomal protein L13A JBrowse link 1 101,120,325 101,123,401 RGD:10002762
G Rpl14 ribosomal protein L14 JBrowse link 8 129,240,528 129,243,400 RGD:10002762
G Rpl15 ribosomal protein L15 JBrowse link 15 8,188,717 8,192,153 RGD:9999448
RGD:10002762
G Rpl17 ribosomal protein L17 JBrowse link 18 70,969,733 70,972,839 RGD:10002762
G Rpl18 ribosomal protein L18 JBrowse link 1 101,700,910 101,703,551 RGD:10002762
G Rpl18a ribosomal protein L18A JBrowse link 16 20,293,277 20,295,283 RGD:10002762
G Rpl19 ribosomal protein L19 JBrowse link 10 85,978,691 85,981,979 RGD:10002762
G Rpl21 ribosomal protein L21 JBrowse link 12 9,996,919 9,999,998 RGD:10002762
G Rpl22 ribosomal protein L22 JBrowse link 5 169,506,150 169,512,875 RGD:10002762
G Rpl23 ribosomal protein L23 JBrowse link 10 85,721,398 85,725,359 RGD:10002762
G Rpl23a ribosomal protein L23a JBrowse link 10 65,441,295 65,443,981 RGD:10002762
G Rpl24 ribosomal protein L24 JBrowse link 11 47,116,885 47,122,093 RGD:10002762
G Rpl26 ribosomal protein L26 JBrowse link 10 55,492,417 55,495,547 RGD:9999448
RGD:10002762
G Rpl27 ribosomal protein L27 JBrowse link 10 89,352,864 89,356,563 RGD:10002762
G Rpl27a ribosomal protein L27a JBrowse link 1 174,132,798 174,135,816 RGD:10002762
G Rpl28 ribosomal protein L28 JBrowse link 1 72,619,282 72,621,941 RGD:10002762
G Rpl29 ribosomal protein L29 JBrowse link 8 115,131,228 115,133,401 RGD:10002762
G Rpl3 ribosomal protein L3 JBrowse link 7 121,297,365 121,302,739 RGD:10002762
G Rpl30 ribosomal protein L30 JBrowse link 7 73,213,538 73,216,431 RGD:10002762
G Rpl31 ribosomal protein L31 JBrowse link 9 46,086,959 46,090,444 RGD:10002762
G Rpl32 ribosomal protein L32 JBrowse link 4 147,715,480 147,719,044 RGD:10002762
G Rpl34 ribosomal protein L34 JBrowse link 2 235,850,281 235,854,021 RGD:10002762
G Rpl35 ribosomal protein L35 JBrowse link 3 23,294,813 23,297,774 RGD:10002762
G Rpl36 ribosomal protein L36 JBrowse link 9 10,441,228 10,441,981 RGD:10002762
G Rpl36a ribosomal protein L36a JBrowse link X 105,402,867 105,405,580 RGD:10002762
G Rpl37 ribosomal protein L37 JBrowse link 2 54,832,634 54,834,587 RGD:10002762
G Rpl37a ribosomal protein L37a JBrowse link 9 80,002,892 80,004,995 RGD:10002762
G Rpl39 ribosomal protein L39 JBrowse link X 123,705,241 123,707,257 RGD:10002762
G Rpl4 ribosomal protein L4 JBrowse link 8 69,121,682 69,126,805 RGD:10002762
G Rpl5 ribosomal protein L5 JBrowse link 14 2,860,963 2,867,397 RGD:10002762
G Rpl6 ribosomal protein L6 JBrowse link 12 40,877,578 40,882,032 RGD:10002762
G Rpl7 ribosomal protein L7 JBrowse link 5 2,633,517 2,636,525 RGD:10002762
G Rpl7a ribosomal protein L7a JBrowse link 3 5,458,985 5,461,627 RGD:10002762
G Rpl8 ribosomal protein L8 JBrowse link 7 117,967,608 117,969,886 RGD:10002762
G Rpl9 ribosomal protein L9 JBrowse link 14 44,524,419 44,527,613 RGD:10002762
G Rplp0 ribosomal protein lateral stalk subunit P0 JBrowse link 12 46,791,528 46,794,797 RGD:10002762
G Rplp1 ribosomal protein lateral stalk subunit P1 JBrowse link 8 66,862,143 66,863,476 RGD:10002762
G Rpp25 ribonuclease P and MRP subunit p25 JBrowse link 8 62,283,336 62,284,716 RGD:6907045
G Rpp30 ribonuclease P/MRP subunit p30 JBrowse link 1 254,697,247 254,720,093 RGD:6907045
G Rpp38 ribonuclease P/MRP subunit p38 JBrowse link 17 78,915,450 78,919,144 RGD:6907045
G Rpp40 ribonuclease P/MRP subunit p40 JBrowse link 17 29,638,647 29,647,709 RGD:6907045
G Rps10 ribosomal protein S10 JBrowse link 20 7,215,762 7,220,331 RGD:10002730
RGD:10002762
G Rps11 ribosomal protein S11 JBrowse link 1 101,116,641 101,118,749 RGD:10002730
RGD:10002762
G Rps12 ribosomal protein S12 JBrowse link 1 22,758,214 22,760,370 RGD:10002730
RGD:10002762
G Rps13 ribosomal protein S13 JBrowse link 1 185,328,902 185,331,332 RGD:10002730
RGD:10002762
G Rps14 ribosomal protein S14 JBrowse link 18 56,042,532 56,047,316 RGD:10002730
RGD:10002762
G Rps15 ribosomal protein S15 JBrowse link 7 12,282,134 12,283,573 RGD:10002730
RGD:10002762
G Rps15a ribosomal protein S15a JBrowse link 1 187,759,865 187,766,734 RGD:10002730
RGD:10002762
G Rps16 ribosomal protein S16 JBrowse link 1 85,405,499 85,408,444 RGD:10002730
RGD:10002762
G Rps18 ribosomal protein S18 JBrowse link 20 5,441,875 5,445,553 RGD:9999448
RGD:10002730
RGD:10002762
G Rps19 ribosomal protein S19 JBrowse link 9 16,802,280 16,807,982 RGD:9999448
RGD:9999449
RGD:10002730
RGD:10002762
G Rps2 ribosomal protein S2 JBrowse link 10 14,088,171 14,090,020 RGD:10002730
RGD:10002762
G Rps20 ribosomal protein S20 JBrowse link 5 16,706,052 16,707,214 RGD:10002730
RGD:10002762
G Rps21 ribosomal protein S21 JBrowse link 3 175,629,176 175,630,198 RGD:10002730
RGD:10002762
G Rps23 ribosomal protein S23 JBrowse link 2 19,823,234 19,824,804 RGD:10002730
RGD:10002762
G Rps24 ribosomal protein S24 JBrowse link 16 757,390 762,091 RGD:10002730
RGD:10002762
G Rps25 ribosomal protein s25 JBrowse link 8 48,727,346 48,729,722 RGD:10002730
RGD:10002762
G Rps26 ribosomal protein S26 JBrowse link 7 3,052,112 3,053,662 RGD:10002730
RGD:10002762
G Rps27 ribosomal protein S27 JBrowse link 2 189,572,175 189,573,280 RGD:10002730
RGD:10002762
G Rps27a ribosomal protein S27a JBrowse link 14 113,966,163 113,968,440 RGD:10002730
RGD:10002762
G Rps27l ribosomal protein S27-like JBrowse link 8 72,741,155 72,746,090 RGD:10002730
G Rps28 ribosomal protein S28 JBrowse link 7 18,682,071 18,683,440 RGD:10002730
RGD:10002762
G Rps29 ribosomal protein S29 JBrowse link 6 91,455,333 91,456,709 RGD:10002730
RGD:10002762
G Rps3 ribosomal protein S3 JBrowse link 1 164,435,868 164,441,167 RGD:10002730
RGD:10002762
G Rps3a ribosomal protein S3a JBrowse link 2 185,440,477 185,444,846 RGD:10002730
RGD:10002762
G Rps4x ribosomal protein S4, X-linked JBrowse link X 72,074,108 72,078,551 RGD:10002730
RGD:10002762
G Rps4y2 ribosomal protein S4, Y-linked 2 JBrowse link 4 182,745,448 182,746,381 RGD:10002730
G Rps5 ribosomal protein S5 JBrowse link 1 65,660,470 65,664,767 RGD:10002730
RGD:10002762
G Rps7 ribosomal protein S7 JBrowse link 6 47,899,525 47,904,389 RGD:10002730
RGD:10002762
G Rps8 ribosomal protein S8 JBrowse link 5 136,020,941 136,023,511 RGD:10002730
RGD:10002762
G Rpsa ribosomal protein SA JBrowse link 8 128,806,053 128,809,987 RGD:10002730
RGD:10002762
G Rrp12 ribosomal RNA processing 12 homolog JBrowse link 1 261,106,768 261,140,416 RGD:10002751
G Rrp7a ribosomal RNA processing 7 homolog A JBrowse link 7 123,980,251 123,990,139 RGD:6907045
G Sbds SBDS, ribosome maturation factor JBrowse link 12 29,921,443 29,930,602 RGD:6907045
G Skiv2l2 Ski2 like RNA helicase 2 JBrowse link 2 44,726,716 44,787,013 RGD:9999445
G Snu13 small nuclear ribonucleoprotein 13 JBrowse link 7 123,282,754 123,287,721 RGD:6907045
RGD:9999451
G Spata5 spermatogenesis associated 5 JBrowse link 2 124,149,872 124,341,138 RGD:6907045
G Taf9 TATA-box binding protein associated factor 9 JBrowse link 2 30,664,407 30,668,414 RGD:6907045
G Tbl3 transducin (beta)-like 3 JBrowse link 10 14,066,984 14,072,197 RGD:6907045
G Tcof1 treacle ribosome biogenesis factor 1 JBrowse link 18 56,081,863 56,115,719 RGD:6907045
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 JBrowse link 16 20,668,925 20,671,127 RGD:10002762
G Utp14a UTP14A small subunit processome component JBrowse link X 135,092,123 135,117,409 RGD:6907045
G Utp15 UTP15, small subunit processome component JBrowse link 2 28,351,925 28,370,315 RGD:6907045
G Utp18 UTP18 small subunit processome component JBrowse link 10 81,560,929 81,588,156 RGD:6907045
G Utp23 UTP23, small subunit processome component JBrowse link 7 91,384,329 91,389,605 RGD:9999445
G Utp4 UTP4 small subunit processome component JBrowse link 19 39,087,995 39,116,124 RGD:6907045
G Utp6 UTP6 small subunit processome component JBrowse link 10 67,255,177 67,285,754 RGD:6907045
G Wdr3 WD repeat domain 3 JBrowse link 2 202,447,749 202,470,398 RGD:6907045
RGD:9999445
G Wdr43 WD repeat domain 43 JBrowse link 6 23,433,532 23,473,179 RGD:6907045
G Wdr75 WD repeat domain 75 JBrowse link 9 52,687,845 52,717,808 RGD:6907045
G Xpo1 exportin 1 JBrowse link 14 108,007,421 108,049,088 RGD:6907045
RGD:10002749
RGD:10002750
G Xpo5 exportin 5 JBrowse link 9 17,125,201 17,163,170 RGD:10002750
G Xrn1 5'-3' exoribonuclease 1 JBrowse link 8 103,774,125 103,883,563 RGD:6907045
G Xrn2 5'-3' exoribonuclease 2 JBrowse link 3 141,224,858 141,298,272 RGD:6907045
RGD:9999445

Pathway Gene Annotations

Disease Annotations Associated with Genes in the ribosome biogenesis pathway
Disease TermsGene Symbols
16Q24.3 Microdeletion SyndromeRpl13
Abnormalities, MultipleSbds
Adenocarcinoma, ProstaticXpo1
Advanced Sleep Phase Syndrome, Familial, 2Csnk1d
Advanced Sleep-Phase Syndrome, Familial, 1Csnk1d
AlcoholismRpl18a
Alopecia, Neurologic Defects, and Endocrinopathy SyndromeRbm28
Alzheimer DiseaseCsnk1d , Csnk1e , Xrn1
Amyotrophic Lateral SclerosisSkiv2l2
Anauxetic Dysplasia 2Pop1
AnemiaDkc1
Anemia, AplasticDkc1 , Sbds
Anemia, Diamond-BlackfanRpl11 , Rpl26 , Rpl5 , Rps10 , Rps19 , Rps24 , Rps7
AnoxiaRps14 , Rps2
Autism, susceptibility to, X-linked 5Rpl10
Autistic DisorderPrkcb , Rpl10 , Rpp25
Autoimmune DiseasesFbl
Bowen-Conradi SyndromeEmg1
Brain InjuriesBysl , Lsg1 , Rps27a , Uba52
Breast NeoplasmsCsnk2a1 , Eif6 , Fbl , Rpl23a , Rpl31 , Rps4x , Rps7 , Rps8 , Xpo1 , Xpo5
CarcinomaRan , Rpl3 , Rpl6 , Rps14
Carcinoma, Adenoid CysticXrn2
Carcinoma, Ductal, BreastCsnk1e
Carcinoma, HepatocellularXpo5
Carcinoma, Non-Small-Cell LungXpo5
Carcinoma, Pancreatic DuctalHeatr1
Carcinoma, Renal CellRpl14
Carcinoma, Squamous CellCsnk2a1 , Csnk2a2 , Csnk2b , Rack1
Carcinoma, Transitional CellXpo5
CardiomegalyPrkcb
Cardiomyopathy, DilatedPrkcb
Cerebellar AtaxiaRpl27a
CholestasisUtp4
Chromosomal InstabilityRps3
Chromosome 5q Deletion SyndromeRps14
Chronic Lymphoid LeukemiaXpo1
Colonic NeoplasmsUba52
Colorectal NeoplasmsPrkcb , Utp23 , Xpo1 , Xpo5
Corpus Callosum Agenesis NeuronopathyNop10
Craniofacial AbnormalitiesTcof1
Diabetes Mellitus, ExperimentalPrkcb , Uba52
Diabetes Mellitus, Type 1Ran
Diabetes Mellitus, Type 2Prkcb
Diabetic NephropathiesPrkcb , Uba52
Diamond-Blackfan Anemia 1Rps19
Diamond-Blackfan Anemia 11Rpl26
Diamond-Blackfan Anemia 12Rpl15
Diamond-Blackfan Anemia 13Rps29
Diamond-Blackfan Anemia 15 with Mandibulofacial DysostosisRps28
DIAMOND-BLACKFAN ANEMIA 16Rpl27
Diamond-Blackfan Anemia 17Rps27
Diamond-Blackfan Anemia 3Rps24
Diamond-Blackfan Anemia 6Rpl5
Diamond-Blackfan Anemia 7Rpl11
Diamond-Blackfan Anemia 8Rps7
Diamond-Blackfan Anemia 9Rps10
Diamond-Blackfan Anemia with Microtia and Cleft PalateRps28
Disease ProgressionBop1 , Exosc5 , Nop56 , Rpl13 , Rpl15 , Rpl18 , Rps15 , Rps19
Down SyndromeRplp0
Dyskeratosis CongenitaDkc1 , Gar1 , Nhp2
Dyskeratosis Congenita, Autosomal RecessiveNhp2 , Nop10
Dyskeratosis Congenita, Autosomal Recessive, 2Nhp2
Ectodermal DysplasiaBms1
Epilepsy, Hearing Loss, and Mental Retardation SyndromeSpata5
Exocrine Pancreatic InsufficiencySbds
Familial Primary Pulmonary HypertensionNop58
Fetal DiseasesPrkcb
GlioblastomaHeatr1 , Rpl5
Glomerulosclerosis, Focal SegmentalNxf7
Hearing Loss, Noise-InducedNob1
Hearing Loss, SensorineuralPrkcb
Heart FailurePrkcb
Heart Septal Defects, VentricularFcf1
Hematologic DiseasesGar1 , Sbds
Herpes SimplexRpl30
HIV InfectionsEif6 , Emg1 , Nup88 , Ran , Taf9
Hoyeraal Hreidarsson SyndromeDkc1
Huntington DiseaseXpo5
HyperalgesiaPrkcb
HyperglycemiaPrkcb
HyperpigmentationRpl27a
HypertensionPrkcb
HypertriglyceridemiaRps12
Hypertrophy, Left VentricularPrkcb
Hypoglossal Nerve InjuriesCsnk2b
HYPOTRICHOSIS 12Rpl21
Immune System DiseasesPrkcb
Infarction, Middle Cerebral ArteryRpl28
Insulin ResistancePrkcb
InsulinomaRps15
Irritable Bowel SyndromeRpsa
Ischemic Attack, TransientRack1
KeloidRan
Kidney Failure, ChronicGtpbp4
LeiomyomaCsnk2b
LeiomyosarcomaXrn2
LEOPARD SyndromeRpl6
Leukemia, Lymphocytic, Chronic, B-CellDkc1 , Xpo1
Leukemia, Myeloid, AcuteDhx15 , Nup214
Leukemia-Lymphoma, Adult T-CellCsnk2a1 , Csnk2b , Prkcb
Leukodystrophy, Hypomyelinating, with Hypodontia and Hypogonadotropic HypogonadismRps24
Liver Cirrhosis, BiliaryUtp4
Liver Cirrhosis, ExperimentalPrkcb
Liver FailureRps10
Long QT SyndromeMdn1
Lung NeoplasmsXrn2
Lupus Erythematosus, SystemicRpl12 , Rpl14
LymphomaRpl11
LymphopeniaDkc1
MacInnes SyndromeRps23
Mammary Neoplasms, AnimalRan , Rpl3 , Rpl6 , Rps14
Mammary Neoplasms, ExperimentalCsnk2a1 , Ran , Rpl3 , Rpl6 , Rps14
Mandibulofacial DysostosisTcof1
MelanomaRpp38 , Rps3
MetachondromatosisRpl6
Microsatellite InstabilityXpo5
Mouth NeoplasmsRack1
Multiple MyelomaXpo5
Myocardial InfarctionCsnk2a1 , Csnk2b
Myocardial IschemiaRpl17
Myocardial Reperfusion InjuryPrkcb
Neoplasm InvasivenessRpsa
NeoplasmsDkc1
Nephrotic syndrome, type 2Xpo5
NeutropeniaRps14
Noonan SyndromeRpl6
North American Indian Childhood CirrhosisUtp4
ObesityPrkcb
OKUR-CHUNG NEURODEVELOPMENTAL SYNDROMECsnk2a1
OsteoarthritisRan
Ovarian CystsRpl5
Ovarian NeoplasmsPop4
Oxygen-Induced RetinopathyCsnk2a1 , Csnk2a2 , Csnk2b
Pancreatic NeoplasmsXpo5
PancytopeniaRpl27a
Parkinson DiseaseRpl14 , Rpl23a , Rpl6 , Rps8
Pleomorphic Xanthoastrocytoma Ddx56 , Mpp6 , Pop7 , Rbm28 , Sbds
Polycystic Ovary SyndromeRexo1 , Rpl37a
Precursor Cell Lymphoblastic Leukemia-LymphomaNup214
Precursor T-Cell Lymphoblastic Leukemia-LymphomaRpl10 , Rpl11 , Rpl5
Primary Ovarian InsufficiencyXpo5
Prostatic NeoplasmsNmd3 , Rpl10 , Rpl12 , Rps19
SchizophreniaSpata5 , Xpo1
Sciatic NeuropathyRan , Rpsa
Shwachman SyndromeSbds
SilicosisPrkcb
Skin NeoplasmsCsnk2a1 , Csnk2a2 , Csnk2b
Small Cell Lung CarcinomaXpo5
Smith-Magenis SyndromeCsnk1d , Rpl19 , Rpl23 , Rpl23a , Rpl27 , Utp18 , Utp6
Spermatogenic Failure, Nonobstructive, Y-LinkedRps4y2
Spinal Cord InjuriesRpsa
Spinocerebellar Ataxia 36Nop56
Splenic HypoplasiaRpsa
Staphylococcal InfectionsXrn1
Status EpilepticusPrkcb , Xrn2
Stomach NeoplasmsBop1 , Exosc5 , Nop56 , Prkcb , Rpl13 , Rpl15 , Rpl18 , Rps15 , Rps19
Thyroid cancer, papillaryWdr3
Uterine NeoplasmsXpo1
Weight GainRpl28 , Rps28 , Rps8
Pathway Annotations Associated with Genes in the ribosome biogenesis pathway
Pathway TermsGene Symbols
3'-end pre-mRNA processing pathwayXrn2
aldosterone signaling pathwayPrkcb
B cell receptor signaling pathwayPrkcb
Bone morphogenetic proteins signaling pathwayNup214
calcium/calcium-mediated signaling pathwayPrkcb
chemokine mediated signaling pathwayPrkcb
CRM1 export pathwayNxf3 , Ran , Xpo1
de novo purine biosynthetic pathwayTaf9
E-cadherin signaling pathwayCsnk2a1 , Csnk2a2 , Csnk2b
Entamoeba histolyca infection pathwayPrkcb
epidermal growth factor/neuregulin signaling pathwayPrkcb
Fc gamma receptor mediated signaling pathwayPrkcb
glioma pathwayPrkcb
glutamate signaling pathwayPrkcb
gonadotropin-releasing hormone signaling pathwayPrkcb
Hedgehog signaling pathwayCsnk1d , Csnk1e , Xpo1
hypoxia inducible factor pathwayRack1
influenza A virus infection pathwayNxf1 , Nxf3 , Nxf7 , Nxt1 , Nxt2 , Prkcb , Xpo1
insulin signaling pathwayPrkcb
insulin-like growth factor signaling pathwayRack1
interleukin-2 signaling pathwayPrkcb
Leishmania infection pathwayPrkcb
long term depressionPrkcb
long term potentiationPrkcb
measles infection pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Rack1
microRNA pathwayRan , Xpo5
mitochondrial autophagy pathwayCsnk2a1 , Csnk2a2 , Csnk2b
mitogen activated protein kinase signaling pathwayPrkcb
mRNA decay pathwayNxf1 , Nxf3 , Nxf7 , Nxt1 , Nxt2
mRNA nuclear export pathwayNup214
non-small cell lung cancer pathwayPrkcb
nuclear factor kappa B signaling pathwayCsnk2a1 , Csnk2a2 , Csnk2b , Ran , Xpo1
NXF1-NXT1 export pathwayNup214 , Nxf1 , Nxt1
p53 signaling pathwayCsnk1d , Csnk1e , Rpl11 , Rpl23
phosphatidylinositol 3-kinase signaling pathwayPrkcb
platelet-derived growth factor signaling pathwayCsnk2a1
protein kinase C (PKC) signaling pathwayPrkcb , Rack1
ribosome biogenesis pathwayBms1 , Bop1 , Bysl , C1d , Csnk1d , Csnk1e , Csnk2a1 , Csnk2a2 , Csnk2b , Ddx10 , Ddx18 , Ddx24 , Ddx56 , Dhx15 , Dhx37 , Dis3 , Dkc1 , Efl1 , Eif6 , Emg1 , Eri1 , Exosc10 , Exosc5 , Fau , Fbl , Fbll1 , Fcf1 , Gar1 , Gnl2 , Gnl3 , Gnl3l , Gtpbp4 , Heatr1 , Imp3 , Imp4 , Lsg1 , Ltv1 , Mdn1 , Mphosph10 , Mpp6 , Nhp2 , Nmd3 , Nob1 , Nol12 , Nop10 , Nop56 , Nop58 , Nup214 , Nup88 , Nvl , Nxf1 , Nxf3 , Nxf7 , Nxt1 , Nxt2 , Pdcd11 , Pes1 , Pno1 , Pop1 , Pop4 , Pop5 , Pop7 , Prkcb , Pwp2 , Rack1 , Ran , Rasl2-9 , Rbm28 , Rcl1 , Rexo1 , Rexo1l1-ps1 , Rexo2 , Rexo5 , RGD1306195 , RGD1566078 , Riok1 , Riok2 , Riok3 , Rpl10 , Rpl10a , Rpl11 , Rpl12 , Rpl13 , Rpl13a , Rpl14 , Rpl15 , Rpl17 , Rpl18 , Rpl18a , Rpl19 , Rpl21 , Rpl22 , Rpl23 , Rpl23a , Rpl24 , Rpl26 , Rpl27 , Rpl27a , Rpl28 , Rpl29 , Rpl3 , Rpl30 , Rpl31 , Rpl32 , Rpl34 , Rpl35 , Rpl36 , Rpl36a , Rpl37 , Rpl37a , Rpl39 , Rpl4 , Rpl5 , Rpl6 , Rpl7 , Rpl7a , Rpl8 , Rpl9 , Rplp0 , Rplp1 , Rpp25 , Rpp30 , Rpp38 , Rpp40 , Rps10 , Rps11 , Rps12 , Rps13 , Rps14 , Rps15 , Rps15a , Rps16 , Rps18 , Rps19 , Rps2 , Rps20 , Rps21 , Rps23 , Rps24 , Rps25 , Rps26 , Rps27 , Rps27a , Rps27l , Rps28 , Rps29 , Rps3 , Rps3a , Rps4x , Rps4y2 , Rps5 , Rps7 , Rps8 , Rpsa , Rrp12 , Rrp7a , Sbds , Skiv2l2 , Snu13 , Spata5 , Taf9 , Tbl3 , Tcof1 , Uba52 , Utp14a , Utp15 , Utp18 , Utp23 , Utp4 , Utp6 , Wdr3 , Wdr43 , Wdr75 , Xpo1 , Xpo5 , Xrn1 , Xrn2
RNA degradation pathwayC1d , Dis3 , Exosc5 , Skiv2l2 , Xrn1 , Xrn2
RNA polymerase II transcription initiation pathwayTaf9
RNA polymerase II transcription termination pathwayXrn2
RNA transport pathwayNmd3 , Nup214 , Nup88 , Nxf1 , Nxf3 , Nxf7 , Nxt1 , Nxt2 , Pop1 , Pop4 , Pop5 , Pop7 , Ran , Rasl2-9 , RGD1306195 , Rpp25 , Rpp30 , Rpp38 , Rpp40 , Xpo1 , Xpo5
spliceosome pathwayDhx15 , RGD1566078 , Snu13
syndecan signaling pathwayRack1
translation pathwayFau , Rpl10 , Rpl10a , Rpl11 , Rpl12 , Rpl13 , Rpl13a , Rpl14 , Rpl15 , Rpl17 , Rpl18 , Rpl18a , Rpl19 , Rpl21 , Rpl22 , Rpl23 , Rpl23a , Rpl24 , Rpl26 , Rpl27 , Rpl27a , Rpl28 , Rpl29 , Rpl3 , Rpl30 , Rpl31 , Rpl32 , Rpl34 , Rpl35 , Rpl36 , Rpl36a , Rpl37 , Rpl37a , Rpl39 , Rpl4 , Rpl5 , Rpl6 , Rpl7 , Rpl7a , Rpl8 , Rpl9 , Rplp0 , Rplp1 , Rps10 , Rps11 , Rps12 , Rps13 , Rps14 , Rps15 , Rps15a , Rps16 , Rps18 , Rps19 , Rps2 , Rps20 , Rps21 , Rps23 , Rps24 , Rps25 , Rps26 , Rps27 , Rps27a , Rps28 , Rps29 , Rps3 , Rps3a , Rps4x , Rps5 , Rps7 , Rps8 , Rpsa , Uba52
tRNA maturation pathwayPop1 , Pop4 , Pop7 , Rpp25 , Rpp30 , Rpp38 , Rpp40
Trypanosoma brucei infection pathwayPrkcb
tumor necrosis factor mediated signaling pathwayRack1
vascular endothelial growth factor signaling pathwayPrkcb
Wnt signaling pathwayCsnk1e , Csnk2a1 , Csnk2a2 , Csnk2b , Prkcb

References Associated with the ribosome biogenesis pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: