RGD Reference Report - DExD/H-box RNA helicases in ribosome biogenesis. - Rat Genome Database

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DExD/H-box RNA helicases in ribosome biogenesis.

Authors: Martin, R  Straub, AU  Doebele, C  Bohnsack, MT 
Citation: Martin R, etal., RNA Biol. 2013 Jan;10(1):4-18. doi: 10.4161/rna.21879. Epub 2012 Aug 24.
RGD ID: 10002738
Pubmed: PMID:22922795   (View Abstract at PubMed)
PMCID: PMC3590236   (View Article at PubMed Central)
DOI: DOI:10.4161/rna.21879   (Journal Full-text)

Ribosome synthesis requires a multitude of cofactors, among them DExD/H-box RNA helicases. Bacterial RNA helicases involved in ribosome assembly are not essential, while eukaryotes strictly require multiple DExD/H-box proteins that are involved in the much more complex ribosome biogenesis pathway. Here, RNA helicases are thought to act in structural remodeling of the RNPs including the modulation of protein binding, and they are required for allowing access or the release of specific snoRNPs from pre-ribosomes. Interestingly, helicase action is modulated by specific cofactors that can regulate recruitment and enzymatic activity. This review summarizes the current knowledge and focuses on recent findings and open questions on RNA helicase function and regulation in ribosome synthesis.

Molecular Pathway Annotations    Click to see Annotation Detail View
Objects Annotated

Genes (Rattus norvegicus)
Ddx10  (DEAD-box helicase 10)
Ddx18  (DEAD-box helicase 18)
Ddx24  (DEAD-box helicase 24)
Ddx56  (DEAD-box helicase 56)
Dhx15  (DEAH-box helicase 15)
Dhx37  (DEAH-box helicase 37)

Genes (Mus musculus)
Ddx10  (DEAD box helicase 10)
Ddx18  (DEAD box helicase 18)
Ddx24  (DEAD box helicase 24)
Ddx56  (DEAD box helicase 56)
Dhx15  (DEAH-box helicase 15)
Dhx37  (DEAH-box helicase 37)

Genes (Homo sapiens)
DDX10  (DEAD-box helicase 10)
DDX18  (DEAD-box helicase 18)
DDX24  (DEAD-box helicase 24)
DDX56  (DEAD-box helicase 56)
DHX15  (DEAH-box helicase 15)
DHX37  (DEAH-box helicase 37)


Additional Information