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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1318464 | 6480464 | Ethinyl Estradiol results in increased expression of SDHB mRNA | CTD | PMID:17555576 PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1318464 | 6480464 | Ethinyl Estradiol results in increased expression of SDHB mRNA | CTD | PMID:17942748 PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1318464 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SDHB mRNA | CTD | PMID:17942748 | 2,2,2-tetramine | multiple interactions | EXP | | 6480464 | Trientine inhibits the reaction [Streptozocin results in increased expression of SDHB protein] | CTD | PMID:19634143 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1318464 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SDHB mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1318464 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SDHB mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SDHB mRNA | CTD | PMID:21215274 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:1318464 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SDHB mRNA | CTD | PMID:20188158 | all-trans-retinoic acid | increases expression | ISO | RGD:1318463 | 6480464 | Tretinoin results in increased expression of SDHB mRNA | CTD | PMID:17218384 | benzo[a]pyrene | multiple interactions | ISO | RGD:1318464 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of SDHB mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | ISO | RGD:1318464 | 6480464 | Benzo(a)pyrene results in increased expression of SDHB mRNA | CTD | PMID:22228805 | benzo[a]pyrene | multiple interactions | ISO | RGD:1318464 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of SDHB mRNA] | CTD | PMID:22228805 | choline | multiple interactions | ISO | RGD:1318464 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SDHB gene | CTD | PMID:20938992 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of SDHB mRNA | CTD | PMID:22465980 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of SDHB mRNA | CTD | PMID:22465980 | cyclosporin A | decreases expression | ISO | RGD:1318463 | 6480464 | Cyclosporine results in decreased expression of SDHB mRNA | CTD | PMID:20106945 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of SDHB mRNA | CTD | PMID:21266533 | dibutyl phthalate | decreases expression | ISO | RGD:1318464 | 6480464 | Dibutyl Phthalate results in decreased expression of SDHB mRNA | CTD | PMID:17361019 | disodium selenite | increases expression | ISO | RGD:1318463 | 6480464 | Sodium Selenite results in increased expression of SDHB mRNA | CTD | PMID:18175754 | folic acid | multiple interactions | ISO | RGD:1318464 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SDHB gene | CTD | PMID:20938992 | genistein | multiple interactions | ISO | RGD:1318463 | 6480464 | ESR2 promotes the reaction [Genistein results in decreased expression of SDHB protein] | CTD | PMID:20884965 | genistein | decreases expression | ISO | RGD:1318463 | 6480464 | Genistein results in decreased expression of SDHB protein | CTD | PMID:20884965 | L-methionine | multiple interactions | ISO | RGD:1318464 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SDHB gene | CTD | PMID:20938992 | lamivudine | multiple interactions | ISO | RGD:1318464 | 6480464 | [Zidovudine co-treated with Lamivudine] results in decreased expression of SDHB mRNA | CTD | PMID:18313992 | lead diacetate | decreases expression | ISO | RGD:1318464 | 6480464 | lead acetate results in decreased expression of SDHB mRNA | CTD | PMID:21829687 | maneb | multiple interactions | ISO | RGD:1318464 | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of SDHB mRNA | CTD | PMID:18386188 | oxaliplatin | decreases expression | ISO | RGD:1318463 | 6480464 | oxaliplatin results in decreased expression of SDHB mRNA | CTD | PMID:17762391 | paracetamol | affects expression | ISO | RGD:1318464 | 6480464 | Acetaminophen affects the expression of SDHB mRNA | CTD | PMID:17562736 | paraquat | multiple interactions | ISO | RGD:1318464 | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of SDHB mRNA | CTD | PMID:18386188 | phlorizin | increases expression | ISO | RGD:1318464 | 6480464 | Phlorhizin results in increased expression of SDHB mRNA | CTD | PMID:22538082 | resveratrol | increases expression | ISO | RGD:1318464 | 6480464 | resveratrol results in increased expression of SDHB mRNA | CTD | PMID:22610192 | rosiglitazone | affects expression | ISO | RGD:1318464 | 6480464 | rosiglitazone affects the expression of SDHB mRNA | CTD | PMID:22013433 | streptozocin | multiple interactions | EXP | | 6480464 | Trientine inhibits the reaction [Streptozocin results in increased expression of SDHB protein] | CTD | PMID:19634143 | streptozocin | increases expression | EXP | | 6480464 | Streptozocin results in increased expression of SDHB protein | CTD | PMID:19634143 | tamoxifen | affects expression | ISO | RGD:1318464 | 6480464 | Tamoxifen affects the expression of SDHB mRNA | CTD | PMID:17555576 | toluene | affects expression | EXP | | 6480464 | Toluene affects the expression of SDHB mRNA | CTD | PMID:21827849 | trans-resveratrol | increases expression | ISO | RGD:1318464 | 6480464 | resveratrol results in increased expression of SDHB mRNA | CTD | PMID:22610192 | zidovudine | decreases expression | ISO | RGD:1318463 | 6480464 | Zidovudine results in decreased expression of SDHB mRNA | CTD | PMID:16894629 | zidovudine | multiple interactions | ISO | RGD:1318464 | 6480464 | [Zidovudine co-treated with Lamivudine] results in decreased expression of SDHB mRNA | CTD | PMID:18313992 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Alzheimer's disease |
| Citrate cycle (TCA cycle) | |
| Huntington's disease | |
| Metabolic pathways | |
| Oxidative phosphorylation | |
| Parkinson's disease | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Alzheimer's disease |
| Citrate cycle (TCA cycle) | |
| Huntington's disease | |
| Metabolic pathways | |
| Oxidative phosphorylation | |
| Parkinson's disease | |
References - curated| 1. |
Astuti D, etal., Am J Hum Genet. 2001 Jul;69(1):49-54. Epub 2001 Jun 12. |
| 2. |
Bardella C, etal., Biochim Biophys Acta. 2011 Nov;1807(11):1432-43. Epub 2011 Jul 13. |
| 3. |
Briere JJ, etal., Cell Mol Life Sci. 2005 Oct;62(19-20):2317-24. |
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GOA data from the GO Consortium |
| 5. |
KEGG |
| 6. |
Lashin OM, etal., Free Radic Biol Med. 2006 Mar 1;40(5):886-96. Epub 2005 Nov 2. |
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MGD data from the GO Consortium |
| 8. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 9. |
RGD automated data pipeline |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
RGD Automated Pipelines |
| 12. |
RGD comprehensive gene curation |
References - uncurated
RGD Disease Portals| Sdhb has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Sdhb (Rattus norvegicus) |
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| SDHB (Homo sapiens) |
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| Sdhb (Mus musculus) |
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Position Markers| RH129180 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001100539 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06040676 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06040677 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06040678 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01040575 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01040576 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01040577 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC158620 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473968 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DQ403001 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ215046 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001100539 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001094009 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001094009 | (Get FASTA) |
| GenBank Protein | AAI58621 | (Get FASTA) |
| ABD77134 | (Get FASTA) | |
| EDL80951 | (Get FASTA) | |
| EDL80952 | (Get FASTA) | |
| EDL80953 | (Get FASTA) | |
| EDL80954 | (Get FASTA) | |
| EDL80955 | (Get FASTA) | |
| EDL80956 | (Get FASTA) | |
| EDL80957 | (Get FASTA) | |
| P21913 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000007967 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000010593 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000010593 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 298596 | ENTREZGENE |
| Gene3D-CATH | Ferredoxin_fold | UniProtKB/Swiss-Prot |
| Fum_reductase_C | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000007967 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 2255 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7446362 | IMAGE-MGC_LOAD |
| InterPro | 2Fe2S_fd_BS | UniProtKB/Swiss-Prot |
| 4Fe4S_Fe-S-bd | UniProtKB/Swiss-Prot | |
| 4Fe4S_Fe_S_CS | UniProtKB/Swiss-Prot | |
| b-grasp_ferredoxin-like | UniProtKB/Swiss-Prot | |
| Ferredoxin | UniProtKB/Swiss-Prot | |
| Fum_reductase_C | UniProtKB/Swiss-Prot | |
| Helical_ferredxn | UniProtKB/Swiss-Prot | |
| Succ_DH/fum_Rdtase_Fe-S | UniProtKB/Swiss-Prot | |
| Succ_DH/fum_Rdtase_N | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:298596 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:187514 | IMAGE-MGC_LOAD |
| Pfam | Fer2_3 | UniProtKB/Swiss-Prot |
| PROSITE | 2FE2S_FER_1 | UniProtKB/Swiss-Prot |
| 2FE2S_FER_2 | UniProtKB/Swiss-Prot | |
| 4FE4S_FER_1 | UniProtKB/Swiss-Prot | |
| 4FE4S_FER_2 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Ferredoxin | UniProtKB/Swiss-Prot |
| Helical_ferredxn | UniProtKB/Swiss-Prot | |
| TIGRFAMs | dhsB | UniProtKB/Swiss-Prot |
| UniGene | Rn.3902 | ENTREZGENE |
| UniProt | DHSB_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-04-30 | Sdhb | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | Sdhb_predicted | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2005-01-12 | Sdhb_predicted | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Sdhb | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1308598 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




