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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-ropivacaine | multiple interactions | ISO | RGD:1342543 | 6480464 | ropivacaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein] | CTD | PMID:9336308 | 17beta-estradiol | increases expression | ISO | RGD:1342543 | 6480464 | Estradiol results in increased expression of SELL mRNA | CTD | PMID:19619570 | 17beta-estradiol | multiple interactions | ISO | RGD:1342543 | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SELL mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1342543 | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SELL mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:737030 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SELL protein | CTD | PMID:15310856 PMID:18684927 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1342543 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SELL mRNA | CTD | PMID:19901195 PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:737030 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SELL protein | CTD | PMID:18684927 PMID:15310856 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1342543 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SELL mRNA | CTD | PMID:19619570 PMID:19901195 | 2,6-di-tert-butyl-4-methylphenol | decreases expression | ISO | RGD:737030 | 6480464 | Butylated Hydroxytoluene results in decreased expression of SELL mRNA | CTD | PMID:19925653 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:1342543 | 6480464 | decitabine results in increased expression of SELL mRNA | CTD | PMID:19194470 | acetylsalicylic acid | decreases expression | ISO | RGD:1342543 | 6480464 | Aspirin results in decreased expression of SELL protein | CTD | PMID:12147693 | afimoxifene | increases expression | ISO | RGD:1342543 | 6480464 | 4-hydroxytamoxifen results in increased expression of SELL mRNA | CTD | PMID:19901195 | all-trans-retinoic acid | increases expression | ISO | RGD:1342543 | 6480464 | Tretinoin results in increased expression of SELL mRNA | CTD | PMID:15498508 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SELL mRNA | CTD | PMID:16483693 | ATP | multiple interactions | ISO | RGD:1342543 | 6480464 | P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein] | CTD | PMID:11003599 | benzo[a]pyrene | decreases expression | ISO | RGD:737030 | 6480464 | Benzo(a)pyrene results in decreased expression of SELL mRNA | CTD | PMID:21569818 | biotin | affects binding | EXP | | 6480464 | [Acetylglucosamine analog binds to Biotin] which binds to SELL protein | CTD | PMID:12191509 | budesonide | multiple interactions | EXP | | 6480464 | Budesonide inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased expression of SELL mRNA] | CTD | PMID:15734790 | capsaicin | increases expression | EXP | | 6480464 | Capsaicin results in increased expression of SELL protein | CTD | PMID:22150557 | capsaicin | multiple interactions | EXP | | 6480464 | [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELL protein]; more ... | CTD | PMID:22150557 | chloroprene | decreases expression | ISO | RGD:737030 | 6480464 | Chloroprene results in decreased expression of SELL mRNA | CTD | PMID:23125180 | cyclosporin A | decreases expression | ISO | RGD:1342543 | 6480464 | Cyclosporine results in decreased expression of SELL mRNA | CTD | PMID:20106945 | diazoxide | multiple interactions | ISO | RGD:1342543 | 6480464 | Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]] | CTD | PMID:9762784 | dichloromethane | increases expression | EXP | | 6480464 | Methylene Chloride results in increased expression of SELL mRNA | CTD | PMID:20955722 | diclofenac | decreases expression | ISO | RGD:1342543 | 6480464 | Diclofenac results in decreased expression of SELL protein | CTD | PMID:12147693 | erythromycin A | increases expression | ISO | RGD:1342543 | 6480464 | Erythromycin results in increased expression of SELL protein | CTD | PMID:16297520 | ethylbenzene | increases expression | EXP | | 6480464 | ethylbenzene results in increased expression of SELL mRNA | CTD | PMID:20955722 | ethylenediaminetetraacetic acid | decreases expression | ISO | RGD:1342543 | 6480464 | Edetic Acid results in decreased expression of SELL protein | CTD | PMID:8595612 | flufenamic acid | decreases expression | ISO | RGD:1342543 | 6480464 | Flufenamic Acid results in decreased expression of SELL protein | CTD | PMID:12147693 | flurbiprofen | decreases expression | ISO | RGD:1342543 | 6480464 | Flurbiprofen results in decreased expression of SELL protein | CTD | PMID:12147693 | heparin | decreases expression | ISO | RGD:1342543 | 6480464 | Heparin results in decreased expression of SELL protein | CTD | PMID:8595612 | heparin | increases expression | ISO | RGD:1342543 | 6480464 | Heparin results in increased expression of SELL protein | CTD | PMID:8993250 | iloprost | decreases expression | ISO | RGD:1342543 | 6480464 | Iloprost results in decreased expression of SELL protein | CTD | PMID:16363279 | indomethacin | decreases expression | ISO | RGD:1342543 | 6480464 | Indomethacin results in decreased expression of SELL protein | CTD | PMID:11980903 PMID:12147693 | indomethacin | decreases expression | ISO | RGD:1342543 | 6480464 | Indomethacin results in decreased expression of SELL protein | CTD | PMID:12147693 PMID:11980903 | isoprenaline | multiple interactions | ISO | RGD:1342543 | 6480464 | Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]] | CTD | PMID:9762784 | ketoprofen | decreases expression | ISO | RGD:1342543 | 6480464 | Ketoprofen results in decreased expression of SELL protein | CTD | PMID:12147693 | leukotriene B4 | increases expression | EXP | | 6480464 | Leukotriene B4 results in increased expression of SELL protein | CTD | PMID:14716214 | lidocaine | multiple interactions | ISO | RGD:1342543 | 6480464 | Lidocaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein] | CTD | PMID:9336308 | methotrexate | decreases expression | ISO | RGD:1342543 | 6480464 | Methotrexate results in decreased expression of SELL mRNA | CTD | PMID:17400583 | morphine | multiple interactions | EXP | | 6480464 | Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]; more ... | CTD | PMID:10070497 | morphine | decreases expression | EXP | | 6480464 | Morphine results in decreased expression of SELL protein alternative form | CTD | PMID:10070497 | N-acetyl-beta-D-glucosamine | affects binding | EXP | | 6480464 | [Acetylglucosamine analog binds to Biotin] which binds to SELL protein; more ... | CTD | PMID:12191509 | N-acetyl-D-glucosamine | affects binding | EXP | | 6480464 | [Acetylglucosamine analog binds to Biotin] which binds to SELL protein; more ... | CTD | PMID:12191509 | N-formyl-L-methionyl-L-leucyl-L-phenylalanine | increases expression | ISO | RGD:737030 | 6480464 | N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELL protein | CTD | PMID:21664406 | naloxone | multiple interactions | EXP | | 6480464 | Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form] | CTD | PMID:10070497 | naproxen | multiple interactions | EXP | | 6480464 | [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELL protein]; more ... | CTD | PMID:22150557 | nickel dichloride | increases expression | EXP | | 6480464 | nickel chloride results in increased expression of SELL protein | CTD | PMID:12028813 | nimesulide | decreases expression | ISO | RGD:1342543 | 6480464 | nimesulide results in decreased expression of SELL protein | CTD | PMID:12147693 | omeprazole | decreases expression | EXP | | 6480464 | Omeprazole results in decreased expression of SELL protein | CTD | PMID:17652263 | ozone | increases expression | EXP | | 6480464 | Ozone results in increased expression of SELL mRNA | CTD | PMID:16330353 | phenylbutazone | affects expression | ISO | RGD:1342543 | 6480464 | Phenylbutazone affects the expression of SELL protein | CTD | PMID:12147693 | pirinixic acid | decreases expression | ISO | RGD:737030 | 6480464 | pirinixic acid results in decreased expression of SELL mRNA | CTD | PMID:20813756 | piroxicam | affects expression | ISO | RGD:1342543 | 6480464 | Piroxicam affects the expression of SELL protein | CTD | PMID:12147693 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of SELL mRNA | CTD | PMID:19162173 | resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of SELL protein | CTD | PMID:21962734 | resveratrol | multiple interactions | ISO | RGD:1342543 | 6480464 | resveratrol analog inhibits the reaction [Calcimycin results in decreased expression of SELL protein] | CTD | PMID:18776917 | resveratrol | multiple interactions | EXP | | 6480464 | resveratrol affects the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased expression of SELL mRNA] | CTD | PMID:15734790 | sumatriptan | multiple interactions | EXP | | 6480464 | [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELL protein]; more ... | CTD | PMID:22150557 | tamibarotene | increases expression | ISO | RGD:1342543 | 6480464 | Am 80 results in increased expression of SELL mRNA; more ... | CTD | PMID:15498508 | thalidomide | decreases expression | ISO | RGD:1342543 | 6480464 | Thalidomide results in decreased expression of SELL protein | CTD | PMID:16344495 | theophylline | multiple interactions | ISO | RGD:1342543 | 6480464 | Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]] | CTD | PMID:9762784 | trans-resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of SELL protein | CTD | PMID:21962734 | trans-resveratrol | multiple interactions | ISO | RGD:1342543 | 6480464 | resveratrol analog inhibits the reaction [Calcimycin results in decreased expression of SELL protein] | CTD | PMID:18776917 | trans-resveratrol | multiple interactions | EXP | | 6480464 | resveratrol affects the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased expression of SELL mRNA] | CTD | PMID:15734790 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SELL mRNA | CTD | PMID:20955722 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Cell adhesion molecules (CAMs) |
Disease Annotations
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Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Cell adhesion molecules (CAMs) |
References - curated| 1. |
Batra A, etal., Nephrol Dial Transplant. 2007 Sep;22(9):2540-8. Epub 2007 Apr 23. |
| 2. |
Benlier E, etal., Burns. 2011 Nov;37(7):1216-21. |
| 3. |
Bigley NJ, etal., J Interferon Cytokine Res. 2008 Feb;28(2):55-63. |
| 4. |
Cai Q, etal., Neurobiol Dis. 2012 Feb;45(2):723-32. Epub 2011 Oct 25. |
| 5. |
Charles N, etal., Nat Med. 2010 Jun;16(6):701-7. Epub 2010 May 30. |
| 6. |
Corsi MM, etal., Biogerontology. 2011 Oct;12(5):451-4. Epub 2011 Apr 12. |
| 7. |
Du HW, etal., Zhonghua Yi Xue Za Zhi. 2009 Jan 6;89(1):59-62. |
| 8. |
Gerik SM, etal., Am J Respir Cell Mol Biol. 2003 Oct;29(4):506-12. Epub 2003 May 1. |
| 9. |
GOA data from the GO Consortium |
| 10. |
Haley M, etal., J Appl Physiol. 2005 Jun;98(6):2155-62. Epub 2005 Jan 27. |
| 11. |
Hannawa KK, etal., Circulation. 2005 Jul 12;112(2):241-7. Epub 2005 Jul 5. |
| 12. |
Haworth O, etal., J Immunol. 2011 Jun 1;186(11):6129-35. Epub 2011 Apr 22. |
| 13. |
Kirveskari J, etal., J Am Soc Nephrol. 2000 Dec;11(12):2358-65. |
| 14. |
Konno R, etal., Am J Reprod Immunol. 2007 Oct;58(4):330-43. |
| 15. |
Kuhl AA, etal., Gastroenterology. 2007 Dec;133(6):1882-92. Epub 2007 Sep 5. |
| 16. |
Li L, etal., Free Radic Biol Med. 2009 Jul 1;47(1):103-13. Epub 2009 Apr 15. |
| 17. |
Lu SY, etal., Clin Exp Immunol. 2011 Aug;165(2):264-77. doi: 10.1111/j.1365-2249.2011.04418.x. Epub 2011 Jun 2. |
| 18. |
Man SF, etal., Ther Adv Respir Dis. 2009 Apr;3(2):73-80. Epub 2009 May 22. |
| 19. |
MGD data from the GO Consortium |
| 20. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 21. |
Ogawa A, etal., J Invest Dermatol. 2010 Jun;130(6):1558-70. Epub 2010 Feb 25. |
| 22. |
RGD automated data pipeline |
| 23. |
RGD automated import pipeline for gene-chemical interactions |
| 24. |
RGD Automated Pipelines |
| 25. |
Rodrigues HG, etal., Lipids. 2010 Sep;45(9):809-19. Epub 2010 Aug 22. |
| 26. |
Royce SG, etal., J Asthma Allergy. 2010 Jun 28;3:9-17. |
| 27. |
Rozenberg I, etal., PLoS One. 2011;6(7):e21675. Epub 2011 Jul 8. |
| 28. |
Sackstein R, etal., Immunology 1995 Jun;85(2):198-204. |
| 29. |
Sergent-Tanguy S, etal., Differentiation. 2006 Dec;74(9-10):530-41. |
| 30. |
Stavarachi M, etal., Rom J Morphol Embryol. 2011;52(3 Suppl):995-8. |
| 31. |
Suzuki Y, etal., Biochem Biophys Res Commun. 1993 Jan 29;190(2):426-34. |
| 32. |
Takei T, etal., Am J Hum Genet. 2002 Mar;70(3):781-6. Epub 2002 Feb 1. |
| 33. |
Tran ED and Schmid-Schonbein GW, Microcirculation. 2007 Nov-Dec;14(8):793-804. |
| 34. |
Watanabe T, etal., Biochim Biophys Acta 1992 Jul 15;1131(3):321-4. |
| 35. |
Wei YS, etal., J Thromb Thrombolysis. 2011 Jul;32(1):110-5. |
| 36. |
Zhao X, etal., Lung. 2005 Mar-Apr;183(2):87-100. |
| 37. |
Zhao X, etal., Respir Physiol Neurobiol. 2006 May;152(1):16-26. Epub 2005 Oct 7. |
| 38. |
Zhong M, etal., Antimicrob Agents Chemother. 2012 Mar 5. |
References - uncurated
RGD Disease Portals| Sell has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Sell (Rattus norvegicus) |
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| SELL (Homo sapiens) |
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| Sell (Mus musculus) |
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Position Markers| D13Got57 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_019177 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06075889 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01076418 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473958 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D10831 | (Get FASTA) | Search GEO for Microarray Profiles | |
| S79523 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_019177 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_062050 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_062050 | (Get FASTA) |
| GenBank Protein | AAC60710 | (Get FASTA) |
| BAA01613 | (Get FASTA) | |
| EDM09363 | (Get FASTA) | |
| EDM09364 | (Get FASTA) | |
| P30836 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000002776 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000003733 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000003733 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 29259 | ENTREZGENE |
| Gene3D-CATH | C-type_lectin-like | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000002776 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 539 | ENTREZGENE |
| InterPro | C-type_lectin | UniProtKB/Swiss-Prot |
| C-type_lectin-like | UniProtKB/Swiss-Prot | |
| C-type_lectin_CS | UniProtKB/Swiss-Prot | |
| C-type_lectin_fold | UniProtKB/Swiss-Prot | |
| EGF-like_reg_CS | UniProtKB/Swiss-Prot | |
| EGF_3 | UniProtKB/Swiss-Prot | |
| EGF_extracell | UniProtKB/Swiss-Prot | |
| L-selectin | UniProtKB/Swiss-Prot | |
| Selectin | UniProtKB/Swiss-Prot | |
| Sushi_SCR_CCP | UniProtKB/Swiss-Prot | |
| IPI | IPI00327594 | UniProtKB/Swiss-Prot |
| IPI00561188 | UniProtKB/TrEMBL | |
| KEGG Report | rno:29259 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | EGF_2 | UniProtKB/Swiss-Prot |
| Lectin_C | UniProtKB/Swiss-Prot | |
| Sushi | UniProtKB/Swiss-Prot | |
| PIRSF | L-selectin | UniProtKB/Swiss-Prot |
| PRINTS | SELECTIN | UniProtKB/Swiss-Prot |
| PROSITE | C_TYPE_LECTIN_1 | UniProtKB/Swiss-Prot |
| C_TYPE_LECTIN_2 | UniProtKB/Swiss-Prot | |
| EGF_1 | UniProtKB/Swiss-Prot | |
| EGF_2 | UniProtKB/Swiss-Prot | |
| EGF_3 | UniProtKB/Swiss-Prot | |
| SUSHI | UniProtKB/Swiss-Prot | |
| SMART | CCP | UniProtKB/Swiss-Prot |
| CLECT | UniProtKB/Swiss-Prot | |
| EGF | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | C-type_lectin_fold | UniProtKB/Swiss-Prot |
| Complement_control_module | UniProtKB/Swiss-Prot | |
| UniGene | Rn.10461 | ENTREZGENE |
| UniProt | LYAM1_RAT | UniProtKB/Swiss-Prot |
| Q63762_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2009-12-15 | Sell | selectin L | Sell | selectin, lymphocyte | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | Sell | selectin, lymphocyte | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed on thymocytes, thoracic duct lymphocytes and lymph node lymphocytes | 729788 |
| gene_expression | expressed in peripheral blood mononuclear cells, spleen and thymus | 69989 |
| gene_physical_interaction | interacts with PPME | 69989 |
| gene_process | expression on lymphocytes allows binding of cells to high endothelial venules (HEV) | 729788 |
| gene_protein | protein is 372 amino acids with a 38 amino acid signal peptide | 69989 |
| gene_regulation | expression in thymocytes may be regulated post-transcriptionally | 729788 |
| gene_regulation | expression in peripheral blood mononuclear and splenic T cells is downregulated upon stimulation with mitogen | 69989 |
| gene_transcript | transcript is 3 kb | 69989 |
| More on Sell | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3655 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




