Gene: Top2a (topoisomerase (DNA) II alpha) Rattus norvegicus
Symbol: Top2a
Name: topoisomerase (DNA) II alpha
Description: ENCODES a protein that exhibits ATP binding; chromatin binding; DNA topoisomerase activity; INVOLVED IN aging; brain development; cerebellar granule cell differentiation; PARTICIPATES IN doxorubicin pharmacodynamics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Carcinoma, Intraductal, Noninfiltrating (ortholog); Cervical Intraepithelial Neoplasia (ortholog); FOUND IN DNA topoisomerase complex (ATP-hydrolyzing); nucleolus; nucleus; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2-acetamidofluorene
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; topoisomerase (DNA) 2 alpha
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01086,901,467 - 86,930,947 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01086,699,277 - 86,728,310 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41087,771,337 - 87,800,960 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11087,785,706 - 87,815,332 (-)NCBI
Celera1082,687,594 - 82,716,976 (-)NCBI
Cytogenetic Map10q31NCBImapview
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Top2a
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 62048
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2016-09-06
Status: ACTIVE