Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:10166 | 6480464 | Tetrachlorodibenzodioxin affects the expression of APC mRNA | CTD | PMID:21570461 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of APC mRNA | CTD | PMID:21346803 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:10166 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of APC mRNA | CTD | PMID:19285098 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:736624 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of APC mRNA | CTD | PMID:12419474 | 4-hydroxynon-2-enal | affects oxidation | ISO | RGD:10166 | 6480464 | APC protein affects the oxidation of 4-hydroxy-2-nonenal | CTD | PMID:21967605 | 4-hydroxynon-2-enal | affects response to substance | ISO | RGD:10166 | 6480464 | APC protein affects the susceptibility to 4-hydroxy-2-nonenal | CTD | PMID:21967605 | 4-hydroxynon-2-enal | multiple interactions | ISO | RGD:10166 | 6480464 | [APC protein affects the oxidation of 4-hydroxy-2-nonenal] which affects the abundance of 4-hydroxynonenoic acid; more ... | CTD | PMID:21967605 | 5-aza-2'-deoxycytidine | affects methylation | ISO | RGD:736624 | 6480464 | decitabine affects the methylation of APC promoter | CTD | PMID:17882284 | 5-aza-2'-deoxycytidine | decreases methylation | ISO | RGD:736624 | 6480464 | decitabine results in decreased methylation of APC promoter | CTD | PMID:18676679 | 8-bromo-3',5'-cyclic AMP | decreases expression | ISO | RGD:736624 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of APC mRNA | CTD | PMID:22079614 | aflatoxin B1 | increases expression | ISO | RGD:10166 | 6480464 | Aflatoxin B1 results in increased expression of APC mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | decreases expression | ISO | RGD:736624 | 6480464 | Tretinoin results in decreased expression of APC mRNA | CTD | PMID:15498508 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of APC mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:10166 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of APC mRNA | CTD | PMID:21715664 | carmustine | affects response to substance | ISO | RGD:736624 | 6480464 | APC mRNA affects the susceptibility to Carmustine | CTD | PMID:16365179 | cobalt dichloride | increases expression | ISO | RGD:736624 | 6480464 | cobaltous chloride results in increased expression of APC mRNA | CTD | PMID:19376846 | copper atom | increases expression | ISO | RGD:736624 | 6480464 | Copper results in increased expression of APC mRNA | CTD | PMID:16629173 | copper(0) | increases expression | ISO | RGD:736624 | 6480464 | Copper results in increased expression of APC mRNA | CTD | PMID:16629173 | curcumin | decreases expression | ISO | RGD:736624 | 6480464 | Curcumin results in decreased expression of APC mRNA | CTD | PMID:15713895 | cypermethrin | increases expression | ISO | RGD:10166 | 6480464 | cypermethrin results in increased expression of APC mRNA | CTD | PMID:21142847 | D-glucose | decreases expression | EXP | | 6480464 | Glucose results in decreased expression of APC mRNA | CTD | PMID:21818840 | dextran sulfate | affects response to substance | ISO | RGD:10166 | 6480464 | APC affects the susceptibility to Dextran Sulfate | CTD | PMID:16049979 | dichlorine | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] affects the expression of APC mRNA | CTD | PMID:18636392 | disodium selenite | decreases methylation | ISO | RGD:736624 | 6480464 | Sodium Selenite results in decreased methylation of APC promoter | CTD | PMID:18676679 | disodium selenite | increases expression | ISO | RGD:736624 | 6480464 | Sodium Selenite results in increased expression of APC mRNA | CTD | PMID:18676679 | elemental selenium | decreases expression | ISO | RGD:736624 | 6480464 | Selenium results in decreased expression of APC mRNA | CTD | PMID:19244175 | etodolac | multiple interactions | EXP | | 6480464 | Etodolac inhibits the reaction [Azoxymethane results in decreased expression of APC mRNA] | CTD | PMID:11076880 | formaldehyde | decreases expression | ISO | RGD:736624 | 6480464 | Formaldehyde results in decreased expression of APC mRNA | CTD | PMID:20655997 | glucose | decreases expression | EXP | | 6480464 | Glucose results in decreased expression of APC mRNA | CTD | PMID:21818840 | hydralazine | decreases methylation | ISO | RGD:736624 | 6480464 | Hydralazine results in decreased methylation of APC promoter | CTD | PMID:15862127 | hydrogen peroxide | decreases expression | ISO | RGD:736624 | 6480464 | Hydrogen Peroxide results in decreased expression of APC mRNA | CTD | PMID:12419474 | indomethacin | increases expression | ISO | RGD:736624 | 6480464 | Indomethacin results in increased expression of APC mRNA; more ... | CTD | PMID:15963497 | indomethacin | multiple interactions | ISO | RGD:10166 | 6480464 | Indomethacin inhibits the reaction [APC gene mutant form results in decreased expression of LPL mRNA]; more ... | CTD | PMID:17546600 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:10166 | 6480464 | Ethylnitrosourea results in increased mutagenesis of APC gene | CTD | PMID:16724327 | N-methyl-N'-nitro-N-nitrosoguanidine | increases expression | ISO | RGD:736624 | 6480464 | Methylnitronitrosoguanidine results in increased expression of APC mRNA | CTD | PMID:12634122 | N-methyl-N-nitrosurea | increases response to substance | ISO | RGD:10166 | 6480464 | APC gene mutant form results in increased susceptibility to Methylnitrosourea | CTD | PMID:12096346 | N-nitrosodiethylamine | decreases expression | EXP | | 6480464 | Diethylnitrosamine results in decreased expression of APC mRNA | CTD | PMID:20360939 | ozone | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] affects the expression of APC mRNA | CTD | PMID:18636392 | paracetamol | affects expression | ISO | RGD:10166 | 6480464 | Acetaminophen affects the expression of APC mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | RGD:10166 | 6480464 | Acetaminophen results in decreased expression of APC mRNA | CTD | PMID:18544908 | paraoxon | increases expression | ISO | RGD:736624 | 6480464 | Paraoxon results in increased expression of APC mRNA | CTD | PMID:17223147 | pirinixic acid | decreases expression | ISO | RGD:10166 | 6480464 | pirinixic acid results in decreased expression of APC mRNA | CTD | PMID:20813756 | quercetin | increases expression | ISO | RGD:736624 | 6480464 | Quercetin results in increased expression of APC mRNA | CTD | PMID:14715546 | selenium atom | decreases expression | ISO | RGD:736624 | 6480464 | Selenium results in decreased expression of APC mRNA | CTD | PMID:19244175 | sulindac | multiple interactions | EXP | | 6480464 | Sulindac inhibits the reaction [Azoxymethane results in decreased expression of APC mRNA] | CTD | PMID:11076880 PMID:12458338 | sulindac | multiple interactions | EXP | | 6480464 | Sulindac inhibits the reaction [Azoxymethane results in decreased expression of APC mRNA] | CTD | PMID:12458338 PMID:11076880 | sulindac | increases expression | EXP | | 6480464 | Sulindac results in increased expression of APC protein | CTD | PMID:12458338 | tamibarotene | decreases expression | ISO | RGD:736624 | 6480464 | Am 80 results in decreased expression of APC mRNA; more ... | CTD | PMID:15498508 | temozolomide | affects response to substance | ISO | RGD:736624 | 6480464 | APC mRNA affects the susceptibility to temozolomide | CTD | PMID:16365179 | uranium atom | affects expression | ISO | RGD:736624 | 6480464 | Uranium affects the expression of APC mRNA | CTD | PMID:15672453 | zinc atom | decreases expression | ISO | RGD:736624 | 6480464 | Zinc deficiency results in decreased expression of APC mRNA | CTD | PMID:18356318 | zinc(0) | decreases expression | ISO | RGD:736624 | 6480464 | Zinc deficiency results in decreased expression of APC mRNA | CTD | PMID:18356318 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
|
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
|
Molecular Pathway Annotations
|
|
| External Database Links | |
| KEGG Pathway | Basal cell carcinoma |
| Colorectal cancer | |
| Endometrial cancer | |
| Hippo signaling pathway | |
| HTLV-I infection | |
| Pathways in cancer | |
| Regulation of actin cytoskeleton | |
| Wnt signaling pathway | |
| Pathway Interaction Database | Canonical Wnt signaling pathway (PID:200077) |
| CDC42 signaling events (PID:200069) | |
| Degradation of beta catenin (PID:200024) | |
| Direct p53 effectors (PID:200120) | |
| Presenilin action in Notch and Wnt signaling (PID:200063) | |
| Regulation of CDC42 activity (PID:200071) | |
| Regulation of nuclear beta catenin signaling and target gene transcription (PID:200176) | |
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) (PID:200041) | |
References - curated| 1. |
Abraham SC, etal., Am J Pathol. 2002 Mar;160(3):953-62. |
| 2. |
Amos-Landgraf JM, etal., Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4036-41. Epub 2007 Feb 27. |
| 3. |
Attard TM, etal., Cancer. 2007 Feb 15;109(4):761-6. |
| 4. |
Becker KG, etal., Nat Genet 2004 May;36(5):431-2. |
| 5. |
Bjork J, etal., Gastroenterology. 2001 Nov;121(5):1127-35. |
| 6. |
Blum CA, etal., Mol Carcinog 2003 Apr;36(4):195-203. |
| 7. |
Chen PC, etal., BMC Med Genomics. 2011 May 20;4:45. doi: 10.1186/1755-8794-4-45. |
| 8. |
Clarke AR, etal., Oncogene. 1995 Nov 2;11(9):1913-20. |
| 9. |
Collin L, etal., Biol Cell. 2008 Apr;100(4):243-52. |
| 10. |
Etienne-Manneville S and Hall A, Nature 2003 Feb 13;421(6924):753-6. |
| 11. |
Farias GG, etal., J Neurosci. 2007 May 16;27(20):5313-25. |
| 12. |
Fodde R, etal., Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8969-73. |
| 13. |
GOA data from the GO Consortium |
| 14. |
Hargreaves GA, etal., Alcohol Clin Exp Res. 2009 Jan;33(1):86-94. Epub 2008 Oct 18. |
| 15. |
Horii A, etal., Cancer Res. 1992 Dec 1;52(23):6696-8. |
| 16. |
Imai Y, etal., Jpn J Cancer Res. 1997 Sep;88(9):846-54. |
| 17. |
Islam MM, etal., J Biol Chem. 2010 Jan 1;285(1):265-76. Epub 2009 Oct 26. |
| 18. |
Kakiuchi H, etal., Proc Natl Acad Sci U S A 1995 Jan 31;92(3):910-4. |
| 19. |
Kang YK, etal., Lab Invest. 1999 Apr;79(4):477-83. |
| 20. |
Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98. |
| 21. |
Langford KJ, etal., Cell Motil Cytoskeleton. 2006 Aug;63(8):483-92. |
| 22. |
Leroy K, etal., Acta Neuropathol. 2001 Jul;102(1):1-10. |
| 23. |
MGD data from the GO Consortium |
| 24. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 25. |
Onouchi T, etal., Med Mol Morphol. 2012 Jun;45(3):152-60. Epub 2012 Sep 22. |
| 26. |
Pecina-Slaus N, etal., J Mol Med (Berl). 1999 May;77(5):446-53. |
| 27. |
Pecina-SLaus N, etal., Pathology. 2004 Apr;36(2):145-51. |
| 28. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 29. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 30. |
RGD automated data pipeline |
| 31. |
RGD automated import pipeline for gene-chemical interactions |
| 32. |
RGD Automated Pipelines |
| 33. |
Sansom OJ, etal., Oncogene. 2005 Dec 8;24(55):8205-10. |
| 34. |
Sansom OJ, etal., Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14122-7. Epub 2006 Sep 7. |
| 35. |
Shimomura A, etal., Neurosci Lett. 2005 Feb 28;375(2):81-6. Epub 2004 Dec 10. |
| 36. |
Strom A, etal., Development. 2007 Aug;134(15):2719-25. Epub 2007 Jun 27. |
| 37. |
Takahashi T, etal., Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6126-33. |
| 38. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 39. |
Votin V, etal., J Cell Sci. 2005 Dec 15;118(Pt 24):5699-708. Epub 2005 Nov 22. |
| 40. |
Wang QM, etal., World J Gastroenterol. 2006 Apr 28;12(16):2615-9. |
| 41. |
Yang B, etal., Mod Pathol. 2005 Mar;18(3):412-20. |
| 42. |
Zhang F, etal., Mol Cell Biol. 2001 Dec;21(23):8143-56. |
References - uncuratedRGD Disease Portals| Apc has been annotated in the following RGD Disease Portals. |
|||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
Candidate Gene StatusComparative Map Data| Apc (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| APC (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Apc (Mus musculus) |
|
Position Markers| PMC122454P1 |
|
||||||||||||||||||||||||||||||
| RH138935 |
|
||||||||||||||||||||||||||||||
| Apc |
|
||||||||||||||||||||||||||||||
| UniSTS:237769 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Related Rat StrainsNucleotide Sequences| Nucleotide RefSeqs | NM_012499 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06094556 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06094557 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01094465 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01094466 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB071693 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473974 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D38629 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L19303 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L19304 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L19305 | (Get FASTA) | Search GEO for Microarray Profiles | |
| L19307 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012499 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_036631 | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_036631 | (Get FASTA) |
| GenBank Protein | BAA07609 | (Get FASTA) |
| BAB68311 | (Get FASTA) | |
| EDL76212 | (Get FASTA) | |
| EDL76213 | (Get FASTA) | |
| EDL76214 | (Get FASTA) | |
| EDL76215 | (Get FASTA) | |
| EDL76216 | (Get FASTA) | |
| EDL76217 | (Get FASTA) | |
| EDL76218 | (Get FASTA) | |
| P70478 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000020423 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000027691 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000027691 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 24205 | ENTREZGENE |
| Gene3D-CATH | ARM-like | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000020423 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 30950 | ENTREZGENE |
| InterPro | APC | UniProtKB/Swiss-Prot |
| APC_15aa | UniProtKB/Swiss-Prot | |
| APC_basic | UniProtKB/Swiss-Prot | |
| APC_crr | UniProtKB/Swiss-Prot | |
| APC_dom | UniProtKB/Swiss-Prot | |
| Apc_fam | UniProtKB/Swiss-Prot | |
| ARM-like | UniProtKB/Swiss-Prot | |
| ARM-type_fold | UniProtKB/Swiss-Prot | |
| Armadillo | UniProtKB/Swiss-Prot | |
| EB1_bd | UniProtKB/Swiss-Prot | |
| SAMP | UniProtKB/Swiss-Prot | |
| IPI | IPI00188859 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:24205 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PTHR12607 | UniProtKB/Swiss-Prot |
| PTHR12607:SF2 | UniProtKB/Swiss-Prot | |
| Pfam | APC_15aa | UniProtKB/Swiss-Prot |
| APC_basic | UniProtKB/Swiss-Prot | |
| APC_crr | UniProtKB/Swiss-Prot | |
| Arm | UniProtKB/Swiss-Prot | |
| EB1_binding | UniProtKB/Swiss-Prot | |
| SAMP | UniProtKB/Swiss-Prot | |
| Suppressor_APC | UniProtKB/Swiss-Prot | |
| PROSITE | ARM_REPEAT | UniProtKB/Swiss-Prot |
| SMART | ARM | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | ARM-type_fold | UniProtKB/Swiss-Prot |
| TIGR | TC228425 | |
| UniGene | Rn.88057 | ENTREZGENE |
| UniProt | APC_RAT | UniProtKB/Swiss-Prot |
| G3V8Q9_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Apc | Adenomatosis polyposis coli | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | mutations are associated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced colon tumors | 634649 |
| gene_disease | human homolog is involved in colon tumorigenesis | 634649 |
| gene_function | interacts with microtubles | 632398 |
| gene_process | may play a role in the regulation of cell polarity | 632398 |
| More on Apc | |
|
Entrez Gene |
|
Ensembl Gene |
| Genome Browser |
|
NCBI Map Viewer |
|
Vista |
|
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2123 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.