Gene: Aif1 (allograft inflammatory factor 1)
Rattus norvegicus
Symbol:
Aif1
Name:
allograft inflammatory factor 1
Description:
ENCODES a protein that exhibits actin filament binding (ortholog); calcium ion binding (ortholog); INVOLVED IN cellular response to chemical stimulus; cellular response to extracellular stimulus; cellular response to hormone stimulus; ASSOCIATED WITH abnormal cell death; ASSOCIATED WITH Alcohol-Induced Disorders, Nervous System; Brain Infarction; Brain Injuries; FOUND IN cell projection; cytoplasm; cytosol; INTERACTS WITH (+)-pilocarpine; (S)-colchicine; 17alpha-ethynylestradiol
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AIF-1; balloon angioplasty responsive transcript; balloon angioplasty-responsive transcript 1; Bart1; iba1; ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule 1; microglia response factor; mrf-1; protein BART-1
Orthologs:
Homo sapiens : AIF1
(allograft inflammatory factor 1)
HGNC
Aif1
(allograft inflammatory factor 1)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 20 p12 NCBI RGSC Genome Assembly v5.0 20 7,234,609 - 7,236,508 - NCBI RGSC Genome Assembly v3.4 20 3,714,428 - 3,716,327 + NCBI Rat Celera Assembly 20 4,373,127 - 4,375,026 - NCBI Genome Assembly 3.1 20 3,714,654 - 3,716,552 NCBI
Model
Disease Annotations
Alcohol-Induced Disorders, Nervous System IEP 2313030 protein:increased expression:cortex, hippocampus (rat) RGD Alzheimer Disease ISS RGD:62217 2313023 protein:altered expression:hippocampus (mouse) RGD Alzheimer Disease ISS RGD:735562 2313045 mRNA:increased expression:frontal cortex (human) RGD Arteriosclerosis ISS RGD:62217 2313033 RGD Brain Infarction IEP 2313025 protein:increased expression:brain subventricular zone (rat) RGD Brain Infarction ISS RGD:737453 2313026 protein:increased expression:brain white matter (human) RGD Brain Injuries IEP 2313020 protein:increased expression:cerebral cortex (rat) RGD Brain Ischemia IEP 2313032 protein:increased expression:cerebral cortex (rat) RGD Cerebral Palsy IEP 2313028 protein:increased expression:corpus callosum (rat) RGD Diabetes Mellitus, Type 1 ISS RGD:735562 2313199 DNA:polymorphism:intron:rs2259571 (human) RGD Diabetes Mellitus, Type 1 Onset IED 2313043 RGD Encephalomyelitis, Autoimmune, Experimental IEP 2313022 protein:altered expression:spinal cord (rat) RGD Glomerulonephritis IEP 2313038 protein:increased expression:kidney (rat) RGD Hyperalgesia IEP 2313035 associated with Alcohol-Induced Disorders, Nervous System; more ... RGD Hypoxia-Ischemia, Brain IEP 2313021 protein:increased expression:right cerebral hemisphere (rat) RGD Inflammation IEP 2313027 protein:increased expression:dentate gyrus (rat) RGD Meningoencephalitis IEP 2313041 protein:increased expression:brain (rat) RGD Motor Neuron Disease IEP 2313029 protein:increased expression:cervical spinal cord (rat) RGD Neuritis, Autoimmune, Experimental IEP 2313042 protein:increased expression:spinal cord (rat) RGD Pain IEP 2313034 associated with Diabetes Mellitus, Experimental; more ... RGD Radiation Injuries, Experimental IEP 2313024 protein:decreased expression:brain (rat) RGD Reperfusion Injury IEP 2313040 protein:increased expression:Kupffer cell (rat) RGD Seizures IEP 2313039 protein:increased expression:brain (rat) RGD sleeping behavior IEP 2313009 RGD Spinal Cord Injuries IEP 2313037 protein:altered expression:spinal cord dorsal horn (rat) RGD Status Epilepticus IEP 2313036 protein:increased expression:dentate gyrus, brain subventricular zone (rat) RGD
Gene-Chemical Interaction Annotations
(+)-pilocarpine increases expression EXP 6480464 Pilocarpine results in increased expression of AIF1 protein CTD PMID:18226170 (S)-colchicine decreases expression EXP 6480464 Colchicine results in decreased expression of AIF1 mRNA CTD PMID:20624997 17alpha-ethynylestradiol increases expression ISO RGD:62217 6480464 Ethinyl Estradiol results in increased expression of AIF1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:62217 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AIF1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of AIF1 mRNA CTD PMID:17351261 17alpha-ethynylestradiol affects expression ISO RGD:62217 6480464 Ethinyl Estradiol affects the expression of AIF1 mRNA CTD PMID:17555576 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:735562 6480464 Tetrachlorodibenzodioxin results in decreased expression of AIF1 mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:62217 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AIF1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735562 6480464 Tetrachlorodibenzodioxin results in increased expression of AIF1 mRNA CTD PMID:19684285 2-nitrofluorene increases expression EXP 6480464 2-nitrofluorene results in increased expression of AIF1 mRNA CTD PMID:14600272 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1,2-dithiol-3-thione results in decreased expression of AIF1 mRNA CTD PMID:19162173 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of AIF1 mRNA CTD PMID:14600272 aflatoxin B1 decreases expression ISO RGD:735562 6480464 Aflatoxin B1 results in decreased expression of AIF1 mRNA CTD PMID:22100608 all-trans-retinoic acid increases expression ISO RGD:735562 6480464 Tretinoin results in increased expression of AIF1 mRNA CTD PMID:15498508 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of AIF1 mRNA CTD PMID:16483693 benzene affects expression EXP 6480464 Benzene affects the expression of AIF1 mRNA CTD PMID:15878777 benzo[a]pyrene multiple interactions ISO RGD:62217 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to AIF1 promoter] CTD PMID:19654925 benzo[a]pyrene increases expression ISO RGD:62217 6480464 Benzo(a)pyrene results in increased expression of AIF1 mRNA CTD PMID:22228805 benzo[a]pyrene multiple interactions ISO RGD:62217 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of AIF1 mRNA] CTD PMID:22228805 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of AIF1 promoter CTD PMID:22457795 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of AIF1 mRNA CTD PMID:22023808 copper(2+) sulfate decreases expression ISO RGD:735562 6480464 Copper Sulfate results in decreased expression of AIF1 mRNA CTD PMID:19549813 diarsenic trioxide decreases expression ISO RGD:735562 6480464 arsenic trioxide results in decreased expression of AIF1 mRNA CTD PMID:19128835 diazoxide decreases expression ISO RGD:62217 6480464 Isoproterenol results in decreased expression of AIF1 mRNA CTD PMID:20003209 hexachlorobenzene affects expression EXP 6480464 Hexachlorobenzene affects the expression of AIF1 mRNA CTD PMID:15159207 isoprenaline decreases expression ISO RGD:62217 6480464 Isoproterenol results in decreased expression of AIF1 mRNA CTD PMID:20003209 lead diacetate increases expression ISO RGD:62217 6480464 lead acetate results in increased expression of AIF1 mRNA CTD PMID:21829687 mycophenolic acid decreases expression EXP 6480464 Mycophenolic Acid results in decreased expression of AIF1 mRNA CTD PMID:10688038 mycophenolic acid multiple interactions EXP 6480464 [Quercetin co-treated with Mycophenolic Acid] results in decreased expression of AIF1 mRNA CTD PMID:10688038 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of AIF1 mRNA CTD PMID:14600272 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of AIF1 mRNA CTD PMID:19162173 pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of AIF1 mRNA CTD PMID:19162173 quercetin multiple interactions EXP 6480464 [Quercetin co-treated with Mycophenolic Acid] results in decreased expression of AIF1 mRNA CTD PMID:10688038 quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of AIF1 mRNA CTD PMID:10688038 quinoline increases activity ISO RGD:735562 6480464 quinoline analog results in increased activity of AIF1 protein CTD PMID:18645022 rosiglitazone decreases expression EXP 6480464 rosiglitazone results in decreased expression of AIF1 mRNA CTD PMID:21515302 tamibarotene increases expression ISO RGD:735562 6480464 Am 80 results in increased expression of AIF1 mRNA; more ... CTD PMID:15498508 valproic acid affects expression ISO RGD:62217 6480464 Valproic Acid affects the expression of AIF1 mRNA CTD PMID:17292431 vincaleukoblastine decreases expression EXP 6480464 Vinblastine results in decreased expression of AIF1 mRNA CTD PMID:20624997
1641893 Alcrsp7 Alcohol response QTL 7 Alcohol response loss of righting reflex 20 1 27477794 Rat 2317851 Alcrsp22 Alcohol response QTL 22 3.2 .05 Alcohol response 20 1 27477794 Rat 1641915 Colcr9 Colorectal carcinoma resistance QTL 9 2.97 .0024 Colorectal carcinoma resistance 20 1 32560683 Rat 6893685 Bw111 Body weight QTL 111 2.7 .004 Body weight salt-loaded 20 1 32910115 Rat 2305926 Iddm37 Insulin dependent diabetes mellitus QTL 37 6 Glucose level 20 1616332 46616332 Rat 2306850 Pia40 Pristane induced arthritis QTL 40 .0001 Joint/bone inflammation pristane induced 20 1616449 5447380 Rat 61448 Ciaa1 CIA Autoantibody QTL 1 30 .001 Anti-type II collagen autoantibody titer collagen induced 20 2790511 4530895 Rat 61472 Aia1 Adjuvant induced arthritis QTL 1 18 .001 Joint/bone inflammation adjuvant induced 20 2790511 4530895 Rat 2317057 Aia27 Adjuvant induced arthritis QTL 27 2.83 Joint/bone inflammation adjuvant induced 20 3039759 37383914 Rat 1598816 Memor12 Memory QTL 12 2.4 Memory navigation-spatial 20 3055886 48055886 Rat 1300152 Bp195 Blood pressure QTL 195 3.46 Blood pressure salt-loaded systolic 20 3660638 9534510 Rat 1331772 Cdexp2 CD45RC expression in CD8 T cells QTL 2 5.7 CD8 T cell CD45RC expression level 20 3660638 10410227 Rat 737973 Pia21 Pristane induced arthritis QTL 21 3.3 Joint/bone inflammation pristane induced 20 3660646 4740814 Rat 61432 Cia1 Collagen induced arthritis QTL 1 Joint/bone inflammation type II collagen induced 20 3660646 14605852 Rat
Gene-Chemical Interaction Annotations
