Gene: Rb1 (retinoblastoma 1)  Rattus norvegicus Symbol: Rb1 Name: retinoblastoma 1 Description: ENCODES a protein that exhibits core promoter binding (ortholog); enzyme binding (ortholog); kinase binding (ortholog); INVOLVED IN cell cycle arrest (ortholog); cell division (ortholog); cell morphogenesis involved in neuron differentiation (ortholog); PARTICIPATES IN ceramide signaling pathway; bladder cancer pathway; cell cycle pathway, mitotic; ASSOCIATED WITH Breast Neoplasms (ortholog); Carcinoma in Situ (ortholog); Carcinoma, Embryonal (ortholog); FOUND IN nucleus; PML body (ortholog); Rb-E2F complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene Type: protein-coding RefSeq Status: VALIDATED Also known as: pp105; pRb; rb; Retinoblastoma 1 (including osteosarcoma); retinoblastoma-associated protein Orthologs: Homo sapiens : RB1 (retinoblastoma 1)  HGNC Mus musculus : Rb1 (retinoblastoma 1)  MGI Latest Assembly: RGSC Genome Assembly v3.4 NCBI Annotation Information: Annotation category: partial on reference assembly Position: Map Chr Position Strand Source Rat Cytogenetic Map 15 q12   NCBI RGSC Genome Assembly v5.0 15 58,804,731 - 58,931,886 - NCBI RGSC Genome Assembly v3.4 15 53,828,881 - 53,962,099 - NCBI Rat Celera Assembly 15 48,020,828 - 48,147,805 - NCBI Genome Assembly 3.1 15 53,844,684 - 53,977,640 - NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Breast Neoplasms   ISS RGD:731712 2291991   RGD   Carcinoma in Situ   ISS RGD:731712 2299891 protein:decreased expression:testis RGD   Carcinoma, Embryonal   ISS RGD:731712 2299891 protein:decreased expression:testis RGD   Carcinoma, Intraductal, Noninfiltrating   ISS RGD:731712 2299890 mRNA, protein:decreased expression:breast RGD   Carcinoma, Renal Cell Disease_progression ISS RGD:731712 2299893   RGD   Cervical Intraepithelial Neoplasia   ISS RGD:731712 2299896 associated with Adenocarcinoma RGD   Endometrial Neoplasms   ISS RGD:731712 2299055   RGD   Osteosarcoma   ISS RGD:731712 7240710   OMIM   Ovarian Neoplasms Disease_progression ISS RGD:731712 2296051   RGD   Ovarian Neoplasms Susceptibility ISS RGD:11219 2299895   RGD   Ovarian Neoplasms Susceptibility ISS RGD:731712 2299894 DNA:SNPs RGD   Phyllodes Tumor Severity ISS RGD:731712 2299889 protein:increased expression:breast RGD   Prostatic Neoplasms   ISS RGD:731712 2299887 DNA:loss of heterozygosity RGD   Retinoblastoma   ISS RGD:731712 7240710   OMIM   Seminoma   ISS RGD:731712 2299891 protein:decreased expression:testis RGD   Urinary Bladder Neoplasms Disease_progression ISS RGD:731712 2299888   RGD   Urinary Bladder Neoplasms   ISS RGD:731712 7240710   OMIM   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:731712 6480464 epigallocatechin gallate results in decreased expression of and results in decreased phosphorylation of RB1 protein CTD PMID:15142168 (-)-epigallocatechin 3-gallate increases expression ISO RGD:731712 6480464 epigallocatechin gallate results in increased expression of RB1 mRNA CTD PMID:18851785 (3S,5R)-fluvastatin decreases phosphorylation ISO RGD:731712 6480464 fluvastatin results in decreased phosphorylation of RB1 protein CTD PMID:16996129 (S)-colchicine multiple interactions ISO RGD:11219 6480464 Colchicine results in decreased phosphorylation of and results in decreased activity of RB1 protein CTD PMID:16495211 (S)-nicotine multiple interactions ISO RGD:731712 6480464 Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; more ... CTD PMID:16862215 (S)-nicotine increases phosphorylation ISO RGD:731712 6480464 Nicotine results in increased phosphorylation of RB1 protein CTD PMID:18805435 more ... (S)-nicotine increases phosphorylation ISO RGD:731712 6480464 Nicotine results in increased phosphorylation of RB1 protein CTD PMID:18805435 more ... (S)-nicotine increases phosphorylation ISO RGD:731712 6480464 Nicotine results in increased phosphorylation of RB1 protein CTD PMID:16862215 more ... (S)-nicotine increases phosphorylation ISO RGD:11219 6480464 Nicotine results in increased phosphorylation of RB1 protein CTD PMID:15574422 (S)-nicotine increases phosphorylation ISO RGD:731712 6480464 Nicotine results in increased phosphorylation of RB1 protein CTD PMID:16862215 more ... (S)-nicotine increases expression ISO RGD:731712 6480464 Nicotine results in increased expression of RB1 protein modified form CTD PMID:20061081 (S)-nicotine decreases expression ISO RGD:731712 6480464 Nicotine results in decreased expression of RB1 protein CTD PMID:16011614 (S)-nicotine multiple interactions ISO RGD:731712 6480464 Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter] CTD PMID:16601104 (S)-nicotine multiple interactions ISO RGD:731712 6480464 L 663536 inhibits the reaction [Nicotine results in increased expression of RB1 protein modified form] CTD PMID:20061081 (S)-nicotine multiple interactions ISO RGD:731712 6480464 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in increased phosphorylation of RB1 protein] CTD PMID:18805435 1,3-thiazolidine-2,4-dione decreases expression ISO RGD:731712 6480464 2,4-thiazolidinedione results in decreased expression of RB1 protein CTD PMID:15916743 17alpha-ethynylestradiol multiple interactions ISO RGD:11219 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RB1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP   6480464 Ethinyl Estradiol results in increased expression of RB1 mRNA CTD PMID:16940010 17beta-estradiol increases phosphorylation ISO RGD:731712 6480464 Estradiol results in increased phosphorylation of RB1 protein CTD PMID:15297603 17beta-estradiol multiple interactions ISO RGD:731712 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased phosphorylation of RB1 protein] CTD PMID:9705214 17beta-estradiol increases phosphorylation ISO RGD:731712 6480464 Estradiol results in increased phosphorylation of RB1 protein CTD PMID:15297603 more ... 17beta-estradiol increases phosphorylation ISO RGD:731712 6480464 Estradiol results in increased phosphorylation of RB1 protein CTD PMID:15297603 PMID:9049186 17beta-estradiol decreases expression ISO RGD:731712 6480464 Estradiol results in decreased expression of RB1 mRNA CTD PMID:19027819 17beta-estradiol increases phosphorylation ISO RGD:11219 6480464 Estradiol results in increased phosphorylation of RB1 protein CTD PMID:15845746 17beta-estradiol multiple interactions ISO RGD:11219 6480464 Lithium Chloride inhibits the reaction [Progesterone inhibits the reaction [Estradiol results in increased phosphorylation of RB1 protein]] CTD PMID:15845746 17beta-hydroxy-5alpha-androstan-3-one decreases phosphorylation ISO RGD:731712 6480464 Dihydrotestosterone results in decreased phosphorylation of RB1 protein CTD PMID:15322241 17beta-hydroxy-5alpha-androstan-3-one increases phosphorylation ISO RGD:731712 6480464 Dihydrotestosterone results in increased phosphorylation of RB1 protein CTD PMID:15647840 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731712 6480464 alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein]; more ... CTD PMID:15157999 2,3,7,8-tetrachlorodibenzodioxine decreases phosphorylation ISO RGD:731712 6480464 Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein CTD PMID:15157999 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731712 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased phosphorylation of RB1 protein] CTD PMID:9705214 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731712 6480464 Tetrachlorodibenzodioxin inhibits the reaction [[AHR protein binds to CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of RB1 protein] CTD PMID:19917880 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:11219 6480464 Tetrachlorodibenzodioxin affects the expression of RB1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP   6480464 Tetrachlorodibenzodioxin results in decreased expression of RB1 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:11219 6480464 [Tetrachlorodibenzodioxin co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased phosphorylation of RB1 protein CTD PMID:20637255 2,3,7,8-tetrachlorodibenzodioxine decreases phosphorylation ISO RGD:731712 6480464 Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein CTD PMID:15157999 PMID:15322241 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:11219 6480464 Tetrachlorodibenzodioxin results in increased expression of RB1 mRNA CTD PMID:12167310 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:11219 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RB1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases phosphorylation ISO RGD:731712 6480464 Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein CTD PMID:15322241 PMID:15157999 2,4-dinitrotoluene affects expression EXP   6480464 2,4-dinitrotoluene affects the expression of RB1 mRNA CTD PMID:21346803 2-acetamidofluorene affects phosphorylation EXP   6480464 2-Acetylaminofluorene affects the phosphorylation of RB1 protein CTD PMID:16448463 2-acetamidofluorene multiple interactions EXP   6480464 2-Acetylaminofluorene results in increased expression of and results in increased phosphorylation of RB1 protein CTD PMID:15158336 2-acetamidofluorene multiple interactions EXP   6480464 RB1 protein affects the reaction [2-Acetylaminofluorene results in increased expression of PSMD10 protein] CTD PMID:16448463 2-butoxyethanol increases expression ISO RGD:11219 6480464 n-butoxyethanol results in increased expression of RB1 mRNA CTD PMID:19812364 2-methylcholine affects expression ISO RGD:731712 6480464 beta-methylcholine affects the expression of RB1 mRNA CTD PMID:21179406 2-nitrofluorene decreases expression EXP   6480464 2-nitrofluorene results in decreased expression of RB1 mRNA CTD PMID:15890375 3-aminobenzamide multiple interactions ISO RGD:731712 6480464 3-aminobenzamide promotes the reaction [RB1 protein binds to E2F1 protein]; more ... CTD PMID:15670817 3-nitropropanoic acid decreases expression EXP   6480464 3-nitropropionic acid results in decreased expression of RB1 protein CTD PMID:21827787 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions ISO RGD:731712 6480464 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of RB1 protein] CTD PMID:18805435 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one decreases expression EXP   6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of RB1 mRNA CTD PMID:15890375 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases phosphorylation ISO RGD:731712 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of RB1 protein CTD PMID:18805435 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid multiple interactions ISO RGD:731712 6480464 [Am 580 co-treated with Retinoids] results in decreased phosphorylation of RB1 protein CTD PMID:15383624 4-hydroxynon-2-enal decreases phosphorylation ISO RGD:731712 6480464 4-hydroxy-2-nonenal results in decreased phosphorylation of RB1 protein CTD PMID:15607904 4-hydroxyphenyl retinamide increases expression ISO RGD:731712 6480464 Fenretinide results in increased expression of RB1 protein CTD PMID:16570282 5-aza-2'-deoxycytidine affects expression ISO RGD:731712 6480464 [decitabine affects the expression of DNMT3B protein] which affects the expression of RB1 mRNA CTD PMID:18544619 5-aza-2'-deoxycytidine decreases expression ISO RGD:731712 6480464 decitabine results in decreased expression of RB1 mRNA CTD PMID:19027819 5-aza-2'-deoxycytidine decreases phosphorylation ISO RGD:731712 6480464 decitabine results in decreased phosphorylation of RB1 protein CTD PMID:12859993 5-fluorouracil affects expression ISO RGD:731712 6480464 Fluorouracil affects the expression of RB1 mRNA CTD PMID:15205334 5-fluorouracil affects response to substance ISO RGD:11219 6480464 RB1 protein affects the susceptibility to Fluorouracil CTD PMID:15064736 5-fluorouracil multiple interactions ISO RGD:731712 6480464 RB1 results in decreased susceptibility to [Fluorouracil co-treated with capecitabine] CTD PMID:18678097 5-fluorouracil affects response to substance ISO RGD:731712 6480464 RB1 protein modified form affects the susceptibility to Fluorouracil CTD PMID:18383818 5-fluorouracil multiple interactions ISO RGD:731712 6480464 Fluorouracil results in increased expression of and results in increased phosphorylation of RB1 protein CTD PMID:17207318 5-fluorouracil affects response to substance ISO RGD:731712 6480464 RB1 protein affects the susceptibility to Fluorouracil CTD PMID:17640669 5-fluorouracil increases phosphorylation ISO RGD:731712 6480464 Fluorouracil results in increased phosphorylation of RB1 protein CTD PMID:9930367 9-cis-retinoic acid decreases phosphorylation ISO RGD:731712 6480464 alitretinoin results in decreased phosphorylation of RB1 protein CTD PMID:16273314 acetylsalicylic acid multiple interactions ISO RGD:731712 6480464 Aspirin inhibits the reaction [troglitazone results in decreased expression of RB1 protein modified form]; more ... CTD PMID:19908241 acetylsalicylic acid increases expression ISO RGD:731712 6480464 Aspirin results in increased expression of RB1 protein CTD PMID:19908241 acetylsalicylic acid decreases expression ISO RGD:731712 6480464 Aspirin results in decreased expression of RB1 protein modified form CTD PMID:19908241 aconitine multiple interactions ISO RGD:731712 6480464 Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] CTD PMID:16862215 aflatoxin B1 decreases expression EXP   6480464 Aflatoxin B1 results in decreased expression of RB1 mRNA CTD PMID:15890375 aflatoxin B1 increases expression ISO RGD:11219 6480464 Aflatoxin B1 results in increased expression of RB1 mRNA CTD PMID:19770486 albuterol decreases expression ISO RGD:731712 6480464 Albuterol results in decreased expression of RB1 protein CTD PMID:16446544 albuterol multiple interactions ISO RGD:731712 6480464 ICI 118551 inhibits the reaction [Albuterol results in decreased expression of RB1 protein] CTD PMID:16446544 albuterol increases expression ISO RGD:731712 6480464 Albuterol results in increased expression of RB1 protein CTD PMID:18362475 all-trans-retinoic acid multiple interactions ISO RGD:731712 6480464 PTK2 protein inhibits the reaction [Tretinoin promotes the reaction [CEBPA protein binds to RB1 protein]] CTD PMID:16226872 all-trans-retinoic acid decreases phosphorylation ISO RGD:731712 6480464 Tretinoin results in decreased phosphorylation of RB1 protein CTD PMID:11519864 more ... all-trans-retinoic acid decreases phosphorylation ISO RGD:731712 6480464 Tretinoin results in decreased phosphorylation of RB1 protein CTD PMID:15383624 more ... all-trans-retinoic acid decreases phosphorylation ISO RGD:731712 6480464 Tretinoin results in decreased phosphorylation of RB1 protein CTD PMID:11519864 more ... all-trans-retinoic acid decreases phosphorylation ISO RGD:731712 6480464 Tretinoin results in decreased phosphorylation of RB1 protein CTD PMID:11519864 more ... all-trans-retinoic acid decreases phosphorylation ISO RGD:731712 6480464 Tretinoin results in decreased phosphorylation of RB1 protein CTD PMID:15695403 more ... all-trans-retinoic acid increases phosphorylation ISO RGD:11219 6480464 Tretinoin results in increased phosphorylation of RB1 protein CTD PMID:15949692 PMID:16840543 all-trans-retinoic acid increases expression ISO RGD:731712 6480464 Tretinoin results in increased expression of RB1 mRNA; more ... CTD PMID:15770638 PMID:15194426 all-trans-retinoic acid decreases phosphorylation ISO RGD:731712 6480464 Tretinoin results in decreased phosphorylation of RB1 protein CTD PMID:9158000 more ... all-trans-retinoic acid decreases phosphorylation ISO RGD:11219 6480464 Tretinoin results in decreased phosphorylation of RB1 protein CTD PMID:18425745 all-trans-retinoic acid increases phosphorylation ISO RGD:11219 6480464 Tretinoin results in increased phosphorylation of RB1 protein CTD PMID:16840543 PMID:15949692 all-trans-retinoic acid decreases expression ISO RGD:11219 6480464 Tretinoin results in decreased expression of RB1 protein CTD PMID:15949692 all-trans-retinoic acid multiple interactions ISO RGD:11219 6480464 Tretinoin inhibits the reaction [RB1 protein binds to RETN promoter] CTD PMID:15047602 all-trans-retinoic acid increases phosphorylation ISO RGD:731712 6480464 Tretinoin results in increased phosphorylation of RB1 protein CTD PMID:16920920 all-trans-retinoic acid multiple interactions ISO RGD:731712 6480464 Tretinoin results in increased expression of and results in decreased phosphorylation of RB1 protein CTD PMID:15194426 all-trans-retinoic acid increases expression ISO RGD:731712 6480464 Tretinoin results in increased expression of RB1 mRNA; more ... CTD PMID:15194426 PMID:15770638 all-trans-retinoic acid increases activity ISO RGD:731712 6480464 Tretinoin results in increased activity of RB1 protein CTD PMID:15194426 all-trans-retinoic acid decreases phosphorylation ISO RGD:731712 6480464 Tretinoin results in decreased phosphorylation of RB1 protein CTD PMID:15126328 more ... all-trans-retinoic acid multiple interactions ISO RGD:731712 6480464 Tretinoin promotes the reaction [CPG-oligonucleotide results in increased phosphorylation of RB1 protein] CTD PMID:17209053 all-trans-retinoic acid decreases expression ISO RGD:731712 6480464 Tretinoin results in decreased expression of RB1 protein CTD PMID:12042460 all-trans-retinoic acid multiple interactions ISO RGD:731712 6480464 [Tretinoin co-treated with TGFB1 protein] results in decreased phosphorylation of RB1 protein CTD PMID:16242776 all-trans-retinoic acid multiple interactions ISO RGD:731712 6480464 Tretinoin inhibits the reaction [IGF1 protein results in increased phosphorylation of RB1 protein] CTD PMID:16565789 all-trans-retinoic acid multiple interactions ISO RGD:731712 6480464 CSF1R promotes the reaction [Tretinoin results in decreased phosphorylation of RB1 protein] CTD PMID:9158000 all-trans-retinoic acid multiple interactions ISO RGD:731712 6480464 Thiophenes analog promotes the reaction [Tretinoin results in decreased phosphorylation of RB1 protein] CTD PMID:16140954 all-trans-retinoic acid multiple interactions ISO RGD:731712 6480464 Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RB1 protein]] CTD PMID:12421932 alpha-hexachlorocyclohexane affects expression EXP   6480464 alpha-hexachlorocyclohexane affects the expression of RB1 mRNA CTD PMID:16940010 alpha-hexachlorocyclohexane increases expression EXP   6480464 alpha-hexachlorocyclohexane results in increased expression of RB1 mRNA CTD PMID:16940010 alpha-hexachlorocyclohexane decreases expression EXP   6480464 alpha-hexachlorocyclohexane results in decreased expression of RB1 mRNA CTD PMID:16940010 amlodipine decreases phosphorylation ISO RGD:731712 6480464 Amlodipine results in decreased phosphorylation of RB1 protein CTD PMID:17217918 ammonium chloride affects expression EXP   6480464 Ammonium Chloride affects the expression of RB1 mRNA CTD PMID:16483693 andrographolide decreases phosphorylation ISO RGD:731712 6480464 andrographolide results in decreased phosphorylation of RB1 protein CTD PMID:18619950 aniline increases phosphorylation EXP   6480464 aniline results in increased phosphorylation of RB1 protein CTD PMID:21070798 arsenic trichloride increases phosphorylation ISO RGD:11219 6480464 arsenic trichloride results in increased phosphorylation of RB1 protein CTD PMID:16283526 auranofin decreases phosphorylation ISO RGD:731712 6480464 Auranofin results in decreased phosphorylation of RB1 protein CTD PMID:20542334 baicalein decreases phosphorylation ISO RGD:731712 6480464 baicalein results in decreased phosphorylation of RB1 protein CTD PMID:22820424 baicalein multiple interactions ISO RGD:731712 6480464 AHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein]; more ... CTD PMID:22820424 benzene increases expression ISO RGD:731712 6480464 Benzene results in increased expression of RB1 protein; more ... CTD PMID:20850422 benzo[a]pyrene decreases expression EXP   6480464 Benzo(a)pyrene results in decreased expression of RB1 mRNA CTD PMID:19408242 PMID:20064080 benzo[a]pyrene increases phosphorylation EXP   6480464 Benzo(a)pyrene results in increased phosphorylation of RB1 protein CTD PMID:17141280 benzo[a]pyrene increases expression EXP   6480464 Benzo(a)pyrene results in increased expression of RB1 protein CTD PMID:19408242 PMID:21467743 benzo[a]pyrene multiple interactions EXP   6480464 AHR affects the reaction [Benzo(a)pyrene results in increased phosphorylation of RB1 protein] CTD PMID:17141280 benzo[a]pyrene decreases expression ISO RGD:11219 6480464 Benzo(a)pyrene results in decreased expression of RB1 mRNA CTD PMID:22228805 benzo[a]pyrene multiple interactions ISO RGD:11219 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of RB1 mRNA] CTD PMID:22228805 benzo[a]pyrene increases expression ISO RGD:11219 6480464 Benzo(a)pyrene results in increased expression of RB1 mRNA CTD PMID:19770486 PMID:22228805 benzo[a]pyrene increases expression ISO RGD:11219 6480464 Benzo(a)pyrene results in increased expression of RB1 mRNA CTD PMID:19770486 benzo[a]pyrene multiple interactions EXP   6480464 Sulfur Dioxide promotes the reaction [Benzo(a)pyrene results in decreased expression of RB1 mRNA]; more ... CTD PMID:20064080 benzo[a]pyrene multiple interactions EXP   6480464 [Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of RB1 mRNA; more ... CTD PMID:19408242 benzo[a]pyrene increases expression EXP   6480464 Benzo(a)pyrene results in increased expression of RB1 protein CTD PMID:19408242 benzo[a]pyrene decreases expression EXP   6480464 Benzo(a)pyrene results in decreased expression of RB1 protein CTD PMID:20064080 benzo[a]pyrene decreases expression EXP   6480464 Benzo(a)pyrene results in decreased expression of RB1 mRNA CTD PMID:20064080 PMID:19408242 benzo[a]pyrene multiple interactions ISO RGD:11219 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of RB1 mRNA CTD PMID:21715664 benzo[a]pyrene increases expression ISO RGD:731712 6480464 Benzo(a)pyrene results in increased expression of RB1 protein; more ... CTD PMID:20850422 bicalutamide increases phosphorylation ISO RGD:731712 6480464 bicalutamide results in increased phosphorylation of RB1 protein CTD PMID:17599054 bis(2-chloroethyl) sulfide increases expression ISO RGD:11219 6480464 Mustard Gas results in increased expression of RB1 mRNA CTD PMID:15674843 bis(2-chloroethyl) sulfide increases phosphorylation ISO RGD:731712 6480464 Mustard Gas results in increased phosphorylation of RB1 protein CTD PMID:19845377 bisphenol A multiple interactions ISO RGD:11219 6480464 bisphenol A results in increased phosphorylation of and results in increased activity of RB1 protein; more ... CTD PMID:21813366 bisphenol A decreases activity ISO RGD:731712 6480464 bisphenol A results in decreased activity of RB1 protein CTD PMID:19654912 bisphenol A increases phosphorylation ISO RGD:731712 6480464 bisphenol A results in increased phosphorylation of RB1 protein CTD PMID:19654912 brassinolide decreases expression ISO RGD:731712 6480464 brassinolide results in decreased expression of RB1 protein modified form CTD PMID:20833159 bucladesine decreases activity ISO RGD:731712 6480464 Bucladesine results in decreased activity of RB1 protein CTD PMID:10697531 bucladesine decreases phosphorylation EXP   6480464 Bucladesine results in decreased phosphorylation of RB1 protein CTD PMID:16718685 bucladesine multiple interactions ISO RGD:731712 6480464 Bucladesine inhibits the reaction [CASP3 protein results in increased cleavage of RB1 protein] CTD PMID:10697531 busulfan decreases phosphorylation ISO RGD:11219 6480464 Busulfan results in decreased phosphorylation of RB1 protein CTD PMID:15388331 caffeine decreases phosphorylation ISO RGD:11219 6480464 Caffeine results in decreased phosphorylation of RB1 protein CTD PMID:15126379 caffeine decreases phosphorylation ISO RGD:731712 6480464 Caffeine results in decreased phosphorylation of RB1 protein CTD PMID:21229324 calciol multiple interactions ISO RGD:731712 6480464 RAF1 mutant form inhibits the reaction [Cholecalciferol results in increased expression of RB1 protein] CTD PMID:18628207 calciol increases expression ISO RGD:731712 6480464 Cholecalciferol results in increased expression of RB1 protein CTD PMID:18628207 calcitriol multiple interactions ISO RGD:731712 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole promotes the reaction [Calcitriol results in increased expression of RB1 mRNA]; more ... CTD PMID:14729647 calcitriol decreases phosphorylation ISO RGD:731712 6480464 Calcitriol results in decreased phosphorylation of RB1 protein CTD PMID:10825140 more ... calcitriol decreases phosphorylation ISO RGD:731712 6480464 Calcitriol results in decreased phosphorylation of RB1 protein CTD PMID:12954644 more ... calcitriol decreases phosphorylation ISO RGD:731712 6480464 Calcitriol results in decreased phosphorylation of RB1 protein CTD PMID:9158000 more ... calcitriol decreases phosphorylation ISO RGD:731712 6480464 Calcitriol results in decreased phosphorylation of RB1 protein CTD PMID:9158000 more ... calcitriol decreases phosphorylation ISO RGD:731712 6480464 Calcitriol results in decreased phosphorylation of RB1 protein CTD PMID:12954644 more ... calcitriol decreases phosphorylation ISO RGD:731712 6480464 Calcitriol results in decreased phosphorylation of RB1 protein CTD PMID:12954644 more ... calcitriol multiple interactions ISO RGD:731712 6480464 CSF1R promotes the reaction [Calcitriol results in decreased phosphorylation of RB1 protein] CTD PMID:9158000 calcitriol increases expression ISO RGD:731712 6480464 Calcitriol results in increased expression of RB1 protein modified form CTD PMID:9348195 calcitriol increases expression ISO RGD:731712 6480464 Calcitriol results in increased expression of RB1 mRNA; more ... CTD PMID:14729647 calcitriol decreases phosphorylation ISO RGD:731712 6480464 Calcitriol results in decreased phosphorylation of RB1 protein CTD PMID:16039115 more ... calcitriol decreases phosphorylation ISO RGD:731712 6480464 Calcitriol results in decreased phosphorylation of RB1 protein modified form CTD PMID:11270487 camptothecin increases phosphorylation ISO RGD:731712 6480464 Camptothecin results in increased phosphorylation of RB1 protein CTD PMID:15585644 camptothecin affects response to substance ISO RGD:11219 6480464 RB1 protein affects the susceptibility to Camptothecin CTD PMID:15064736 camptothecin increases phosphorylation ISO RGD:11219 6480464 Camptothecin results in increased phosphorylation of RB1 protein CTD PMID:14647467 camptothecin affects response to substance ISO RGD:731712 6480464 RB1 protein affects the susceptibility to Camptothecin CTD PMID:14704340 capecitabine multiple interactions ISO RGD:731712 6480464 RB1 results in decreased susceptibility to [Fluorouracil co-treated with capecitabine] CTD PMID:18678097 cefaloridine affects activity EXP   6480464 Cephaloridine affects the activity of RB1 protein CTD PMID:18500788 celecoxib multiple interactions ISO RGD:731712 6480464 [atorvastatin co-treated with celecoxib] results in decreased expression of RB1 protein modified form; more ... CTD PMID:18172863 celecoxib increases expression EXP   6480464 celecoxib results in increased expression of RB1 protein; more ... CTD PMID:12960143 celecoxib increases expression ISO RGD:731712 6480464 celecoxib results in increased expression of RB1 CTD PMID:19846907 cisplatin affects response to substance ISO RGD:731712 6480464 RB1 protein affects the susceptibility to Cisplatin CTD PMID:14704340 PMID:17640669 cisplatin affects response to substance ISO RGD:731712 6480464 RB1 protein affects the susceptibility to Cisplatin CTD PMID:17640669 PMID:14704340 cisplatin increases expression ISO RGD:11219 6480464 Cisplatin results in increased expression of RB1 mRNA CTD PMID:21151649 clofibric acid multiple interactions EXP   6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RB1 mRNA CTD PMID:17602206 copper atom affects expression ISO RGD:731712 6480464 Copper affects the expression of RB1 mRNA CTD PMID:16246896 copper atom increases expression ISO RGD:731712 6480464 Copper results in increased expression of RB1 mRNA CTD PMID:16391388 copper(0) affects expression ISO RGD:731712 6480464 Copper affects the expression of RB1 mRNA CTD PMID:16246896 copper(0) increases expression ISO RGD:731712 6480464 Copper results in increased expression of RB1 mRNA CTD PMID:16391388 crocidolite asbestos affects expression ISO RGD:731712 6480464 Asbestos, Crocidolite affects the expression of RB1 mRNA CTD PMID:17331233 cumene multiple interactions ISO RGD:11219 6480464 [cumene co-treated with KRAS gene mutant form] results in decreased expression of RB1 mRNA CTD PMID:18648096 curcumin decreases phosphorylation ISO RGD:731712 6480464 Curcumin results in decreased phosphorylation of RB1 protein CTD PMID:18156803 curcumin decreases phosphorylation ISO RGD:11219 6480464 Curcumin results in decreased phosphorylation of RB1 protein CTD PMID:15738001 daunorubicin increases expression ISO RGD:731712 6480464 Daunorubicin results in increased expression of RB1 mRNA CTD PMID:12656675 DDT increases phosphorylation ISO RGD:731712 6480464 DDT results in increased phosphorylation of RB1 protein CTD PMID:9049186 dehydroepiandrosterone increases expression EXP   6480464 Dehydroepiandrosterone results in increased expression of RB1 mRNA CTD PMID:16940010 dehydroepiandrosterone multiple interactions ISO RGD:731712 6480464 Dehydroepiandrosterone results in decreased expression of and results in decreased phosphorylation of RB1 protein CTD PMID:15752352 desferrioxamine B decreases phosphorylation ISO RGD:731712 6480464 Deferoxamine results in decreased phosphorylation of RB1 protein CTD PMID:11468187 dexamethasone increases phosphorylation ISO RGD:731712 6480464 Dexamethasone results in increased phosphorylation of RB1 protein CTD PMID:16510457 dexamethasone decreases expression ISO RGD:11219 6480464 Dexamethasone results in decreased expression of RB1 mRNA CTD PMID:21041162 dexamethasone increases activity EXP   6480464 Dexamethasone results in increased activity of RB1 protein CTD PMID:19158320 dexamethasone decreases phosphorylation EXP   6480464 Dexamethasone results in decreased phosphorylation of RB1 protein CTD PMID:9442036 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [CDK2 protein results in increased phosphorylation of RB1 protein] CTD PMID:9442036 diarsenic trioxide decreases expression ISO RGD:731712 6480464 arsenic trioxide results in decreased expression of RB1 protein modified form CTD PMID:20953137 diarsenic trioxide decreases phosphorylation ISO RGD:731712 6480464 arsenic trioxide results in decreased phosphorylation of RB1 protein CTD PMID:12480548 dibutyl phthalate increases phosphorylation EXP   6480464 Dibutyl Phthalate results in increased phosphorylation of RB1 protein CTD PMID:16916955 dicoumarol increases phosphorylation ISO RGD:731712 6480464 Dicumarol results in increased phosphorylation of RB1 protein CTD PMID:15896341 diethylstilbestrol decreases expression EXP   6480464 Diethylstilbestrol results in decreased expression of RB1 mRNA CTD PMID:15890375 diethylstilbestrol increases expression ISO RGD:11219 6480464 Diethylstilbestrol results in increased expression of RB1 mRNA CTD PMID:15545218 dioxygen increases expression ISO RGD:11219 6480464 Oxygen deficiency results in increased expression of RB1 mRNA CTD PMID:22629407 dioxygen multiple interactions ISO RGD:11219 6480464 Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of RB1 mRNA] CTD PMID:22629407 docetaxel anhydrous multiple interactions ISO RGD:731712 6480464 [docetaxel co-treated with flavopiridol] results in decreased phosphorylation of and results in decreased expression of RB1 protein; more ... CTD PMID:15297405 doxazosin affects phosphorylation EXP   6480464 Doxazosin affects the phosphorylation of RB1 protein CTD PMID:18084315 doxazosin decreases phosphorylation ISO RGD:731712 6480464 Doxazosin results in decreased phosphorylation of RB1 protein CTD PMID:15371785 doxorubicin affects expression ISO RGD:731712 6480464 Doxorubicin affects the expression of RB1 mRNA CTD PMID:15205334 doxorubicin multiple interactions ISO RGD:731712 6480464 Doxorubicin promotes the reaction [RB1 protein binds to PCNA promoter] CTD PMID:16537896 doxorubicin decreases phosphorylation ISO RGD:731712 6480464 Doxorubicin results in decreased phosphorylation of RB1 protein CTD PMID:15141020 emodin decreases expression ISO RGD:731712 6480464 Emodin results in decreased expression of RB1 mRNA CTD PMID:16045814 ethanol affects expression EXP   6480464 Ethanol affects the expression of RB1 mRNA CTD PMID:11772933 etoposide affects response to substance ISO RGD:731712 6480464 RB1 protein affects the susceptibility to Etoposide CTD PMID:17640669 everolimus multiple interactions ISO RGD:731712 6480464 everolimus results in decreased phosphorylation of and affects the activity of RB1 protein; more ... CTD PMID:16033851 everolimus decreases phosphorylation ISO RGD:731712 6480464 everolimus results in decreased phosphorylation of RB1 protein CTD PMID:16856892 ferulic acid decreases phosphorylation EXP   6480464 ferulic acid results in decreased phosphorylation of RB1 protein CTD PMID:15363954 ferulic acid decreases phosphorylation ISO RGD:731712 6480464 ferulic acid results in decreased phosphorylation of RB1 protein CTD PMID:15486966 flavanone decreases phosphorylation ISO RGD:731712 6480464 flavanone results in decreased phosphorylation of RB1 protein CTD PMID:22056764 gadolinium trichloride increases phosphorylation ISO RGD:731712 6480464 gadolinium chloride results in increased phosphorylation of RB1 protein CTD PMID:19184457 gamma-hexachlorocyclohexane decreases expression EXP   6480464 Lindane results in decreased expression of RB1 mRNA CTD PMID:17785943 genistein multiple interactions ISO RGD:731712 6480464 Genistein results in increased phosphorylation of and results in decreased activity of RB1 protein; more ... CTD PMID:17051425 glutathione multiple interactions ISO RGD:731712 6480464 Glutathione inhibits the reaction [Levamisole results in decreased expression of RB1 protein] CTD PMID:11139434 heparin multiple interactions ISO RGD:731712 6480464 Heparin analog results in decreased expression of and results in decreased phosphorylation of RB1 protein CTD PMID:20201787 heptachlor decreases expression ISO RGD:731712 6480464 Heptachlor results in decreased expression of RB1 protein CTD PMID:10048758 hydrogen peroxide multiple interactions ISO RGD:731712 6480464 calyculin A inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of RB1 protein]; more ... CTD PMID:12621062 hydrogen peroxide multiple interactions ISO RGD:731712 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RB1 protein CTD PMID:18951874 hydrogen peroxide decreases phosphorylation ISO RGD:731712 6480464 Hydrogen Peroxide results in decreased phosphorylation of RB1 protein CTD PMID:12621062 PMID:15242773 hydrogen peroxide decreases phosphorylation ISO RGD:731712 6480464 Hydrogen Peroxide results in decreased phosphorylation of RB1 protein CTD PMID:15242773 PMID:12621062 hydrogen peroxide decreases expression ISO RGD:731712 6480464 Hydrogen Peroxide results in decreased expression of RB1 mRNA CTD PMID:12419474 ibuprofen decreases phosphorylation EXP   6480464 Ibuprofen results in decreased phosphorylation of RB1 protein CTD PMID:15099639 imatinib multiple interactions ISO RGD:731712 6480464 imatinib results in decreased phosphorylation of and results in decreased expression of RB1 protein CTD PMID:15100154 indomethacin multiple interactions EXP   6480464 Indomethacin inhibits the reaction [FGF2 protein results in increased phosphorylation of RB1 protein] CTD PMID:11170841 indomethacin decreases phosphorylation ISO RGD:731712 6480464 Indomethacin results in decreased phosphorylation of RB1 protein CTD PMID:18791128 ketamine decreases expression EXP   6480464 Ketamine results in decreased expression of RB1 mRNA CTD PMID:20080153 L-cysteine decreases phosphorylation ISO RGD:731712 6480464 Cysteine analog results in decreased phosphorylation of RB1 protein CTD PMID:15890017 letrozole multiple interactions ISO RGD:731712 6480464 [letrozole co-treated with everolimus] results in decreased phosphorylation of and affects the activity of RB1 protein; more ... CTD PMID:16033851 letrozole multiple interactions ISO RGD:731712 6480464 [Sirolimus co-treated with letrozole] results in decreased expression of RB1 protein; more ... CTD PMID:20054642 lithium chloride multiple interactions ISO RGD:11219 6480464 Lithium Chloride inhibits the reaction [Progesterone inhibits the reaction [Estradiol results in increased phosphorylation of RB1 protein]] CTD PMID:15845746 lithium chloride multiple interactions ISO RGD:731712 6480464 Lithium Chloride inhibits the reaction [baicalein results in decreased phosphorylation of RB1 protein] CTD PMID:22820424 lovastatin decreases phosphorylation ISO RGD:731712 6480464 Lovastatin results in decreased phosphorylation of RB1 protein CTD PMID:15118409 PMID:10502407 lovastatin decreases phosphorylation ISO RGD:731712 6480464 Lovastatin results in decreased phosphorylation of RB1 protein CTD PMID:10502407 PMID:15118409 lovastatin decreases phosphorylation EXP   6480464 Lovastatin results in decreased phosphorylation of RB1 protein CTD PMID:9848777 LY294002 multiple interactions ISO RGD:11219 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased phosphorylation of RB1 protein] CTD PMID:14971663 LY294002 decreases phosphorylation ISO RGD:11219 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RB1 protein CTD PMID:15601625 LY294002 multiple interactions ISO RGD:731712 6480464 [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased phosphorylation of RB1 protein] CTD PMID:15778701 lycopene multiple interactions ISO RGD:731712 6480464 lycopene inhibits the reaction [Genistein results in increased phosphorylation of and results in decreased activity of RB1 protein] CTD PMID:17051425 lycopene multiple interactions ISO RGD:731712 6480464 lycopene inhibits the reaction [IGF1 protein results in increased phosphorylation of RB1 protein] CTD PMID:16565789 lycopene decreases phosphorylation ISO RGD:731712 6480464 lycopene results in decreased phosphorylation of RB1 protein CTD PMID:17337101 menadione increases expression ISO RGD:731712 6480464 Vitamin K 3 results in increased expression of RB1 mRNA CTD PMID:16010434 menaquinone increases expression ISO RGD:731712 6480464 Vitamin K 2 results in increased expression of RB1 mRNA CTD PMID:16010434 methapyrilene decreases expression EXP   6480464 Methapyrilene results in decreased expression of RB1 mRNA CTD PMID:15890375 methotrexate affects response to substance ISO RGD:731712 6480464 RB1 gene affects the susceptibility to Methotrexate CTD PMID:14679136 methotrexate increases response to substance ISO RGD:731712 6480464 RB1 protein results in increased susceptibility to Methotrexate CTD PMID:14534726 methotrexate affects response to substance ISO RGD:731712 6480464 RB1 protein affects the susceptibility to Methotrexate CTD PMID:12972956 methoxsalen multiple interactions ISO RGD:731712 6480464 Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein] CTD PMID:15157999 mifepristone increases activity ISO RGD:731712 6480464 Mifepristone results in increased activity of RB1 protein CTD PMID:15297425 mitomycin C decreases expression ISO RGD:731712 6480464 Mitomycin results in decreased expression of RB1 protein modified form CTD PMID:15617745 myo-inositol hexakisphosphate decreases phosphorylation ISO RGD:731712 6480464 Phytic Acid results in decreased phosphorylation of RB1 protein CTD PMID:15868430 N-acetyl-L-cysteine multiple interactions ISO RGD:731712 6480464 Acetylcysteine inhibits the reaction [5-nitroso-8-quinolinol results in decreased expression of RB1 protein modified form] CTD PMID:16497787 N-acetyl-L-cysteine multiple interactions ISO RGD:731712 6480464 Acetylcysteine inhibits the reaction [Levamisole results in decreased expression of RB1 protein] CTD PMID:11139434 N-ethyl-N-nitrosourea increases expression EXP   6480464 Ethylnitrosourea results in increased expression of RB1 mRNA CTD PMID:15954086 N-methyl-4-phenylpyridinium decreases phosphorylation ISO RGD:731712 6480464 1-Methyl-4-phenylpyridinium results in decreased phosphorylation of RB1 protein CTD PMID:15247282 N-methyl-N-nitrosurea increases phosphorylation EXP   6480464 Methylnitrosourea results in increased phosphorylation of RB1 protein CTD PMID:15581186 N-nitrosodiethylamine multiple interactions ISO RGD:11219 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ANAPC5 mRNA]; more ... CTD PMID:17854601 N-nitrosodiethylamine multiple interactions ISO RGD:11219 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MCM7 protein]; more ... CTD PMID:19887370 PMID:17854601 N-nitrosodiethylamine increases expression EXP   6480464 Diethylnitrosamine results in increased expression of RB1 protein CTD PMID:19822196 N-nitrosodiethylamine decreases expression EXP   6480464 Diethylnitrosamine results in decreased expression of RB1 mRNA CTD PMID:19638242 N-nitrosodiethylamine multiple interactions EXP   6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of RB1 mRNA CTD PMID:17602206 N-nitrosodiethylamine decreases response to substance ISO RGD:11219 6480464 RB1 protein results in decreased susceptibility to Diethylnitrosamine CTD PMID:17854601 N-nitrosodiethylamine multiple interactions EXP   6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of RB1 mRNA; more ... CTD PMID:18164116 N-nitrosodiethylamine multiple interactions ISO RGD:11219 6480464 RB1 protein promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN2D mRNA]; more ... CTD PMID:18282651 N-nitrosodiethylamine multiple interactions ISO RGD:11219 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of E2F1 protein]; more ... CTD PMID:17854601 PMID:19887370 N-nitrosodiethylamine multiple interactions ISO RGD:11219 6480464 RB1 protein affects the reaction [Diethylnitrosamine results in increased expression of RBL1 protein] CTD PMID:19887370 N-nitrosodimethylamine decreases expression EXP   6480464 Dimethylnitrosamine results in decreased expression of RB1 mRNA CTD PMID:15890375 nickel dichloride decreases expression ISO RGD:731712 6480464 nickel chloride results in decreased expression of RB1 protein CTD PMID:21837363 okadaic acid multiple interactions ISO RGD:731712 6480464 Okadaic Acid inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of RB1 protein] CTD PMID:12621062 oleic acid decreases phosphorylation ISO RGD:731712 6480464 Oleic Acid results in decreased phosphorylation of RB1 protein CTD PMID:16027227 oxaliplatin decreases phosphorylation ISO RGD:731712 6480464 oxaliplatin results in decreased phosphorylation of RB1 protein CTD PMID:15204521 PMID:16227409 oxaliplatin decreases phosphorylation ISO RGD:731712 6480464 oxaliplatin results in decreased phosphorylation of RB1 protein CTD PMID:16227409 PMID:15204521 oxaliplatin increases phosphorylation ISO RGD:731712 6480464 oxaliplatin results in increased phosphorylation of RB1 protein CTD PMID:15204521 paclitaxel increases phosphorylation ISO RGD:731712 6480464 Paclitaxel results in increased phosphorylation of RB1 protein CTD PMID:15138593 paclitaxel multiple interactions ISO RGD:731712 6480464 PD 98059 inhibits the reaction [Paclitaxel results in increased phosphorylation of RB1 protein] CTD PMID:15138593 paracetamol increases expression ISO RGD:731712 6480464 Acetaminophen results in increased expression of RB1 mRNA CTD PMID:22230336 pentachlorophenol increases phosphorylation EXP   6480464 Pentachlorophenol results in increased phosphorylation of RB1 protein CTD PMID:19442831 pentobarbital decreases expression EXP   6480464 Pentobarbital results in decreased expression of RB1 protein modified form CTD PMID:19346066 phenobarbital decreases expression EXP   6480464 Phenobarbital results in decreased expression of RB1 mRNA CTD PMID:16940010 phenylephrine increases expression EXP   6480464 Phenylephrine results in increased expression of RB1 protein CTD PMID:15603588 phenylephrine affects phosphorylation EXP   6480464 Phenylephrine affects the phosphorylation of RB1 protein CTD PMID:18084315 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:731712 6480464 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RB1 protein]; more ... CTD PMID:12421932 phorbol 13-acetate 12-myristate increases phosphorylation ISO RGD:731712 6480464 Tetradecanoylphorbol Acetate results in increased phosphorylation of RB1 protein CTD PMID:12421932 PMID:8927716 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:731712 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RB1 mRNA CTD PMID:16979875 phorbol 13-acetate 12-myristate increases phosphorylation ISO RGD:731712 6480464 Tetradecanoylphorbol Acetate results in increased phosphorylation of RB1 protein CTD PMID:12421932 phorbol 13-acetate 12-myristate increases expression ISO RGD:731712 6480464 Tetradecanoylphorbol Acetate results in increased expression of RB1 protein modified form CTD PMID:9348195 phorbol 13-acetate 12-myristate decreases phosphorylation ISO RGD:731712 6480464 Tetradecanoylphorbol Acetate results in decreased phosphorylation of RB1 protein CTD PMID:15978937 pioglitazone multiple interactions ISO RGD:731712 6480464 pioglitazone results in decreased phosphorylation of and results in decreased expression of RB1 protein CTD PMID:15729575 piperonyl butoxide decreases expression EXP   6480464 Piperonyl Butoxide results in decreased expression of RB1 mRNA CTD PMID:15890375 pirinixic acid increases expression EXP   6480464 pirinixic acid results in increased expression of RB1 mRNA CTD PMID:16940010 pirinixic acid decreases expression EXP   6480464 pirinixic acid results in decreased expression of RB1 mRNA CTD PMID:15890375 piroxicam decreases expression ISO RGD:731712 6480464 Piroxicam results in decreased expression of RB1 mRNA CTD PMID:21858171 prednisone multiple interactions ISO RGD:731712 6480464 Prednisone results in decreased phosphorylation of and results in decreased activity of RB1 protein CTD PMID:15034294 progesterone multiple interactions ISO RGD:11219 6480464 Lithium Chloride inhibits the reaction [Progesterone inhibits the reaction [Estradiol results in increased phosphorylation of RB1 protein]] CTD PMID:15845746 pterostilbene decreases expression EXP   6480464 pterostilbene results in decreased expression of RB1 protein CTD PMID:20398797 quercetin affects expression ISO RGD:731712 6480464 Quercetin affects the expression of RB1 protein modified form CTD PMID:14767529 quercetin decreases phosphorylation ISO RGD:731712 6480464 Quercetin results in decreased phosphorylation of RB1 protein CTD PMID:16049707 PMID:19009557 quercetin increases expression ISO RGD:731712 6480464 Quercetin results in increased expression of RB1 mRNA CTD PMID:14715546 quercetin decreases phosphorylation ISO RGD:731712 6480464 Quercetin results in decreased phosphorylation of RB1 protein CTD PMID:19009557 PMID:16049707 raloxifene decreases expression ISO RGD:731712 6480464 Raloxifene results in decreased expression of RB1 mRNA CTD PMID:19429434 rel-(3R,5S)-fluvastatin decreases phosphorylation ISO RGD:731712 6480464 fluvastatin results in decreased phosphorylation of RB1 protein CTD PMID:16996129 resveratrol decreases phosphorylation ISO RGD:731712 6480464 resveratrol results in decreased phosphorylation of RB1 protein CTD PMID:16761963 PMID:17804729 resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of RB1 protein modified form CTD PMID:22104698 resveratrol decreases phosphorylation ISO RGD:731712 6480464 resveratrol results in decreased phosphorylation of RB1 protein CTD PMID:11481417 more ... resveratrol decreases phosphorylation ISO RGD:731712 6480464 resveratrol results in decreased phosphorylation of RB1 protein CTD PMID:16761963 more ... resveratrol decreases phosphorylation ISO RGD:731712 6480464 resveratrol results in decreased phosphorylation of RB1 protein CTD PMID:17804729 PMID:16761963 resveratrol affects expression ISO RGD:11219 6480464 resveratrol affects the expression of RB1 mRNA; more ... CTD PMID:16369916 romidepsin decreases phosphorylation ISO RGD:731712 6480464 romidepsin results in decreased phosphorylation of RB1 protein CTD PMID:15014036 PMID:15849726 romidepsin decreases phosphorylation ISO RGD:731712 6480464 romidepsin results in decreased phosphorylation of RB1 protein CTD PMID:15849726 PMID:15014036 rosiglitazone multiple interactions ISO RGD:731712 6480464 rosiglitazone results in decreased phosphorylation of and results in decreased expression of RB1 protein CTD PMID:15729575 rosiglitazone increases phosphorylation ISO RGD:731712 6480464 rosiglitazone results in increased phosphorylation of RB1 protein CTD PMID:20210794 rosiglitazone decreases phosphorylation ISO RGD:731712 6480464 rosiglitazone results in decreased phosphorylation of RB1 protein CTD PMID:21376716 S-(1,2-dichlorovinyl)-L-cysteine increases phosphorylation ISO RGD:11219 6480464 S-(1,2-dichlorovinyl)cysteine results in increased phosphorylation of RB1 protein CTD PMID:16495211 simvastatin decreases phosphorylation ISO RGD:731712 6480464 Simvastatin results in decreased phosphorylation of RB1 protein CTD PMID:17928568 simvastatin decreases phosphorylation EXP   6480464 Simvastatin results in decreased phosphorylation of RB1 protein CTD PMID:18804536 sirolimus multiple interactions ISO RGD:731712 6480464 [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased phosphorylation of RB1 protein] CTD PMID:15778701 sirolimus decreases phosphorylation ISO RGD:731712 6480464 Sirolimus results in decreased phosphorylation of RB1 protein CTD PMID:12393642 more ... sirolimus decreases phosphorylation ISO RGD:731712 6480464 Sirolimus results in decreased phosphorylation of RB1 protein CTD PMID:12393642 more ... sirolimus decreases phosphorylation ISO RGD:731712 6480464 Sirolimus results in decreased phosphorylation of RB1 protein CTD PMID:15753396 more ... sirolimus decreases phosphorylation ISO RGD:731712 6480464 Sirolimus results in decreased phosphorylation of RB1 protein CTD PMID:21528311 more ... sirolimus decreases phosphorylation ISO RGD:731712 6480464 Sirolimus results in decreased phosphorylation of RB1 protein CTD PMID:12393642 more ... sirolimus decreases phosphorylation ISO RGD:731712 6480464 Sirolimus results in decreased phosphorylation of RB1 protein CTD PMID:12565877 more ... sirolimus multiple interactions ISO RGD:11219 6480464 [TGFB1 protein co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein CTD PMID:12417722 sirolimus decreases phosphorylation EXP   6480464 Sirolimus results in decreased phosphorylation of RB1 protein CTD PMID:7532117 sirolimus multiple interactions ISO RGD:11219 6480464 [Sirolimus co-treated with TGFB1 protein] results in decreased phosphorylation of RB1 protein CTD PMID:14979923 sirolimus multiple interactions ISO RGD:11219 6480464 Sirolimus inhibits the reaction [KITL protein results in increased phosphorylation of RB1 protein] CTD PMID:10849422 sirolimus multiple interactions ISO RGD:731712 6480464 Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RB1 protein] CTD PMID:10373522 sirolimus decreases phosphorylation ISO RGD:731712 6480464 Sirolimus results in decreased phosphorylation of RB1 protein CTD PMID:12393642 more ... sirolimus multiple interactions ISO RGD:731712 6480464 [TGFB1 protein co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein CTD PMID:17700525 sirolimus multiple interactions ISO RGD:731712 6480464 [Sirolimus co-treated with TGFB1 protein] results in decreased phosphorylation of RB1 protein CTD PMID:14979923 sirolimus multiple interactions ISO RGD:731712 6480464 [Sirolimus co-treated with letrozole] results in decreased expression of RB1 protein CTD PMID:20054642 sirolimus multiple interactions ISO RGD:731712 6480464 [17-(allylamino)-17-demethoxygeldanamycin co-treated with Sirolimus] results in decreased phosphorylation of RB1 protein; more ... CTD PMID:17121904 sulforaphane increases phosphorylation ISO RGD:731712 6480464 sulforafan results in increased phosphorylation of RB1 protein CTD PMID:15231455 sulfur dioxide multiple interactions EXP   6480464 [Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of RB1 mRNA; more ... CTD PMID:19408242 sulfur dioxide decreases expression EXP   6480464 Sulfur Dioxide results in decreased expression of RB1 protein CTD PMID:19434695 PMID:20064080 sulfur dioxide decreases expression EXP   6480464 Sulfur Dioxide results in decreased expression of RB1 mRNA CTD PMID:19408242 more ... sulfur dioxide decreases expression EXP   6480464 Sulfur Dioxide results in decreased expression of RB1 mRNA CTD PMID:19408242 PMID:20064080 sulfur dioxide decreases expression EXP   6480464 Sulfur Dioxide results in decreased expression of RB1 protein CTD PMID:20064080 sulfur dioxide increases expression EXP   6480464 Sulfur Dioxide results in increased expression of RB1 protein CTD PMID:19408242 sulfur dioxide decreases expression EXP   6480464 Sulfur Dioxide results in decreased expression of RB1 mRNA CTD PMID:20064080 PMID:19408242 sulfur dioxide multiple interactions EXP   6480464 Sulfur Dioxide promotes the reaction [Benzo(a)pyrene results in decreased expression of RB1 mRNA]; more ... CTD PMID:20064080 sulindac decreases expression ISO RGD:731712 6480464 Sulindac results in decreased expression of RB1 protein CTD PMID:16488075 tamoxifen multiple interactions ISO RGD:731712 6480464 [Tamoxifen co-treated with FTI 277] results in decreased phosphorylation of RB1 protein CTD PMID:12866041 tamoxifen multiple interactions EXP   6480464 [Tamoxifen results in increased expression of MIR106A mRNA] which results in decreased expression of RB1 protein CTD PMID:17343880 tamoxifen decreases expression EXP   6480464 Tamoxifen results in decreased expression of RB1 protein CTD PMID:17343880 tamoxifen increases phosphorylation ISO RGD:11219 6480464 Tamoxifen results in increased phosphorylation of RB1 protein CTD PMID:15642790 tamoxifen decreases phosphorylation ISO RGD:731712 6480464 Tamoxifen results in decreased phosphorylation of RB1 protein CTD PMID:14645110 tamoxifen multiple interactions ISO RGD:731712 6480464 PD 98059 inhibits the reaction [Tamoxifen results in decreased phosphorylation of RB1 protein] CTD PMID:14645110 tazarotene multiple interactions ISO RGD:731712 6480464 [tazarotene co-treated with Retinoids] results in decreased phosphorylation of RB1 protein CTD PMID:15383624 terephthalic acid increases expression EXP   6480464 terephthalic acid results in increased expression of RB1 protein CTD PMID:16896691 terephthalic acid increases phosphorylation EXP   6480464 terephthalic acid results in increased phosphorylation of RB1 protein CTD PMID:16896691 tert-butyl hydroperoxide decreases expression ISO RGD:731712 6480464 tert-Butylhydroperoxide results in decreased expression of RB1 mRNA CTD PMID:15336504 PMID:12419474 tert-butyl hydroperoxide decreases expression ISO RGD:731712 6480464 tert-Butylhydroperoxide results in decreased expression of RB1 mRNA CTD PMID:12419474 PMID:15336504 tetrachloromethane multiple interactions ISO RGD:11219 6480464 CDKN1A protein affects the reaction [Carbon Tetrachloride results in increased phosphorylation of RB1 protein] CTD PMID:12759355 tetrachloromethane increases phosphorylation EXP   6480464 Carbon Tetrachloride results in increased phosphorylation of RB1 protein CTD PMID:17256749 tetrachloromethane increases phosphorylation ISO RGD:11219 6480464 Carbon Tetrachloride results in increased phosphorylation of RB1 protein CTD PMID:12759355 tetrachloromethane increases expression ISO RGD:11219 6480464 Carbon Tetrachloride results in increased expression of RB1 mRNA CTD PMID:15056808 theophylline multiple interactions ISO RGD:731712 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of RB1 protein CTD PMID:18951874 thioacetamide multiple interactions EXP   6480464 Thioacetamide results in increased phosphorylation of and results in decreased activity of RB1 protein CTD PMID:15953624 thioacetamide decreases expression EXP   6480464 Thioacetamide results in decreased expression of RB1 mRNA CTD PMID:16337175 tocopherol decreases phosphorylation ISO RGD:731712 6480464 Tocopherols results in decreased phosphorylation of RB1 protein CTD PMID:12504091 tolbutamide decreases phosphorylation EXP   6480464 Tolbutamide results in decreased phosphorylation of RB1 protein CTD PMID:16718685 trans-resveratrol decreases phosphorylation ISO RGD:731712 6480464 resveratrol results in decreased phosphorylation of RB1 protein CTD PMID:16761963 PMID:17804729 trans-resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of RB1 protein modified form CTD PMID:22104698 trans-resveratrol decreases phosphorylation ISO RGD:731712 6480464 resveratrol results in decreased phosphorylation of RB1 protein CTD PMID:11481417 more ... trans-resveratrol decreases phosphorylation ISO RGD:731712 6480464 resveratrol results in decreased phosphorylation of RB1 protein CTD PMID:16761963 more ... trans-resveratrol decreases phosphorylation ISO RGD:731712 6480464 resveratrol results in decreased phosphorylation of RB1 protein CTD PMID:17804729 PMID:16761963 trans-resveratrol affects expression ISO RGD:11219 6480464 resveratrol affects the expression of RB1 mRNA; more ... CTD PMID:16369916 trichostatin A affects expression ISO RGD:731712 6480464 [trichostatin A affects the expression of DNMT3B protein] which affects the expression of RB1 mRNA CTD PMID:18544619 trichostatin A multiple interactions ISO RGD:731712 6480464 trichostatin A results in decreased phosphorylation of and results in increased expression of RB1 protein CTD PMID:15179185 trichostatin A decreases activity ISO RGD:731712 6480464 trichostatin A results in decreased activity of RB1 protein CTD PMID:15494029 troglitazone multiple interactions ISO RGD:731712 6480464 Aspirin inhibits the reaction [troglitazone results in decreased expression of RB1 protein modified form]; more ... CTD PMID:19908241 troglitazone decreases expression ISO RGD:731712 6480464 troglitazone results in decreased expression of RB1 protein modified form CTD PMID:11834241 PMID:19908241 troglitazone increases phosphorylation ISO RGD:731712 6480464 troglitazone results in increased phosphorylation of RB1 protein CTD PMID:11741176 troglitazone decreases expression ISO RGD:731712 6480464 troglitazone results in decreased expression of RB1 protein modified form CTD PMID:19908241 PMID:11834241 troglitazone decreases phosphorylation ISO RGD:731712 6480464 troglitazone results in decreased phosphorylation of RB1 protein CTD PMID:12595159 troglitazone increases expression ISO RGD:731712 6480464 troglitazone results in increased expression of RB1 protein CTD PMID:19908241 troglitazone multiple interactions ISO RGD:731712 6480464 troglitazone results in decreased phosphorylation of and results in decreased expression of RB1 protein CTD PMID:15729575 troglitazone decreases expression ISO RGD:731712 6480464 troglitazone results in decreased expression of RB1 protein modified form CTD PMID:19908241 urethane decreases expression ISO RGD:11219 6480464 Urethane results in decreased expression of RB1 mRNA CTD PMID:12117781 ursodeoxycholic acid decreases expression ISO RGD:731712 6480464 Ursodeoxycholic Acid results in decreased expression of RB1 protein modified form CTD PMID:17461466 valproic acid increases expression ISO RGD:11219 6480464 Valproic Acid results in increased expression of RB1 mRNA CTD PMID:21427059 valproic acid increases expression ISO RGD:11219 6480464 Valproic Acid results in increased expression of RB1 mRNA CTD PMID:20546886 PMID:21427059 valproic acid increases expression ISO RGD:11219 6480464 Valproic Acid results in increased expression of RB1 mRNA CTD PMID:21427059 PMID:20546886 vinyl carbamate decreases expression ISO RGD:11219 6480464 vinyl carbamate results in decreased expression of RB1 mRNA CTD PMID:17849452 wortmannin multiple interactions ISO RGD:11219 6480464 wortmannin inhibits the reaction [KITL protein results in increased phosphorylation of RB1 protein] CTD PMID:10849422 wortmannin multiple interactions ISO RGD:11219 6480464 wortmannin inhibits the reaction [Vanadates results in increased phosphorylation of RB1 protein] CTD PMID:14971663 zinc atom multiple interactions ISO RGD:731712 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RB1 mRNA CTD PMID:16979875 zinc sulfate decreases expression ISO RGD:731712 6480464 Zinc Sulfate results in decreased expression of RB1 mRNA CTD PMID:12756304 zinc(0) multiple interactions ISO RGD:731712 6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RB1 mRNA CTD PMID:16979875 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell cycle arrest   ISO RGD:11219 1624291 MGI:MGI:3575978|PMID:15831459 RGD MGI:MGI:3575978 PMID:15831459 cell cycle arrest   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 cell division   ISO RGD:11219 1624291 MGI:MGI:1857242 RGD MGI:MGI:3578603 PMID:15843406 cell division   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 cell morphogenesis involved in neuron differentiation   ISO RGD:11219 1624291 MGI:MGI:1857339 RGD MGI:MGI:3664376 PMID:7958874 cell morphogenesis involved in neuron differentiation   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 chromatin modification   IEA UniProtKB-KW:KW-0156 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 digestive tract development   ISO RGD:11219 1624291 MGI:MGI:1931018|MGI:MGI:3574761 RGD MGI:MGI:3703460 PMID:17257418 digestive tract development   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 enucleate erythrocyte differentiation   ISO RGD:11219 1624291 MGI:MGI:1857242|MGI:MGI:2384134 RGD MGI:MGI:3525032 PMID:15616565 enucleate erythrocyte differentiation   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 G1/S transition of mitotic cell cycle   ISO RGD:11219 1624291 MGI:MGI:3575978|PMID:15831459 RGD MGI:MGI:3575978 PMID:15831459 maintenance of mitotic sister chromatid cohesion   ISO RGD:731712 1624291 PMID:20551165 RGD PMID:20551165 maintenance of mitotic sister chromatid cohesion   IEA Ensembl:ENSP00000267163 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 myoblast differentiation   ISO RGD:731712 1624291 PMID:15541338 RGD PMID:15541338 myoblast differentiation   ISS UniProtKB:P06400 1600115 GO_REF:0000024 UniProtKB GO_REF:0000024 negative regulation of cell cycle   ISO RGD:11219 1624291 MGI:MGI:2667557|PMID:12853964 RGD MGI:MGI:2667557 PMID:12853964 negative regulation of cell proliferation   ISO RGD:11219 1624291 MGI:MGI:1857242 RGD MGI:MGI:3578603 PMID:15843406 negative regulation of cell proliferation   ISO RGD:11219 1624291 MGI:MGI:97306 RGD MGI:MGI:2445783 PMID:11246230 negative regulation of epithelial cell proliferation   ISO RGD:11219 1624291 MGI:MGI:1931018|MGI:MGI:3574761 RGD MGI:MGI:3703460 PMID:17257418 negative regulation of epithelial cell proliferation   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of G1/S transition of mitotic cell cycle   ISO RGD:11219 1624291 MGI:MGI:1857339 RGD MGI:MGI:3664376 PMID:7958874 negative regulation of protein kinase activity   ISO RGD:731712 1624291 UniProtKB:P21675 RGD PMID:9858607 negative regulation of protein kinase activity   ISS UniProtKB:P06400 1600115 GO_REF:0000024 UniProtKB GO_REF:0000024 negative regulation of smoothened signaling pathway   ISO RGD:11219 1624291 MGI:MGI:1931018|MGI:MGI:3574761 RGD MGI:MGI:3703460 PMID:17257418 negative regulation of smoothened signaling pathway   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of transcription from RNA polymerase II promoter   ISO RGD:11219 1624291 MGI:MGI:2386376|PMID:12200151 RGD MGI:MGI:2386376 PMID:12200151 negative regulation of transcription from RNA polymerase II promoter   ISO RGD:11219 1624291 UniProtKB:Q01094 RGD MGI:MGI:5285162 PMID:20224733 negative regulation of transcription from RNA polymerase II promoter   ISO RGD:11219 1624291 MGI:MGI:104813 RGD MGI:MGI:3589998 PMID:15870077 negative regulation of transcription involved in G1/S phase of mitotic cell cycle   ISO RGD:11219 1624291 UniProtKB:Q01094 RGD MGI:MGI:5285162 PMID:20224733 negative regulation of transcription involved in G1/S phase of mitotic cell cycle   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of transcription, DNA-dependent   ISO RGD:11219 1624291 MGI:MGI:3052717|PMID:11331592 RGD MGI:MGI:3052717 PMID:11331592 negative regulation of transcription, DNA-dependent   ISO RGD:731712 1624291 PMID:19223331 RGD PMID:19223331 negative regulation of transcription, DNA-dependent   ISO RGD:731712 1624291 PMID:12065415 RGD PMID:12065415 negative regulation of transcription, DNA-dependent   ISO RGD:731712 1624291 PMID:10783144 RGD PMID:10783144 neuron apoptotic process   ISO RGD:11219 1624291 MGI:MGI:1857339 RGD MGI:MGI:3664376 PMID:7958874 neuron apoptotic process   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 neuron differentiation   ISO RGD:11219 1624291 MGI:MGI:1857339 RGD MGI:MGI:3664376 PMID:7958874 neuron maturation   ISO RGD:11219 1624291 MGI:MGI:1857339 RGD MGI:MGI:3664376 PMID:7958874 neuron maturation   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 neuron projection development   ISO RGD:11219 1624291 MGI:MGI:1857339 RGD MGI:MGI:3664376 PMID:7958874 neuron projection development   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of macrophage differentiation   ISO RGD:11219 1624291 MGI:MGI:1857242|MGI:MGI:2384134 RGD MGI:MGI:3525032 PMID:15616565 positive regulation of macrophage differentiation   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of mitotic metaphase/anaphase transition   ISO RGD:731712 1624291 PMID:20551165 RGD PMID:20551165 positive regulation of mitotic metaphase/anaphase transition   IEA Ensembl:ENSP00000267163 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of transcription from RNA polymerase II promoter   ISO RGD:11219 1624291 MGI:MGI:1339708|MGI:MGI:1352454 RGD MGI:MGI:3579756 PMID:15701640 positive regulation of transcription from RNA polymerase II promoter   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 protein localization to chromosome, centromeric region   ISO RGD:731712 1624291 PMID:20551165 RGD PMID:20551165 protein localization to chromosome, centromeric region   IEA Ensembl:ENSP00000267163 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Ras protein signal transduction   ISO RGD:731712 1624291 PMID:9054499 RGD PMID:9054499 Ras protein signal transduction   IEA Ensembl:ENSP00000267163 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of cell cycle   ISO RGD:11219 1624291 MGI:MGI:1857242 RGD MGI:MGI:3583041 PMID:15898111 regulation of cohesin localization to chromatin   ISO RGD:731712 1624291 PMID:20551165 RGD PMID:20551165 regulation of cohesin localization to chromatin   IEA Ensembl:ENSP00000267163 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of lipid kinase activity   ISO RGD:731712 1624291 PMID:16286473 RGD PMID:16286473 regulation of lipid kinase activity   ISS UniProtKB:P06400 1600115 GO_REF:0000024 UniProtKB GO_REF:0000024 regulation of mitotic cell cycle   ISO RGD:731712 1624291 PMID:20551165 RGD PMID:20551165 regulation of S phase of mitotic cell cycle   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 sister chromatid biorientation   ISO RGD:731712 1624291 PMID:20551165 RGD PMID:20551165 sister chromatid biorientation   IEA Ensembl:ENSP00000267163 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 skeletal muscle cell differentiation   ISO RGD:11219 1624291 MGI:MGI:5300631|PMID:22147266 RGD MGI:MGI:5300631 PMID:22147266 striated muscle cell differentiation   ISO RGD:11219 1624291 MGI:MGI:96680 RGD MGI:MGI:3511080 PMID:15542848 striated muscle cell differentiation   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 transcription, DNA-dependent   IEA UniProtKB-KW:KW-0804 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) nucleus   IDA   1581722   RGD   nucleus   ISS UniProtKB:P06400 1600115 GO_REF:0000024 UniProtKB GO_REF:0000024 nucleus   ISO RGD:731712 1624291 PMID:17540172 RGD PMID:17540172 nucleus   ISO RGD:11219 1624291 MGI:MGI:1333653|PMID:10082561 RGD MGI:MGI:1333653 PMID:10082561 nucleus   ISO RGD:11219 1624291 MGI:MGI:3525032|PMID:15616565 RGD MGI:MGI:3525032 PMID:15616565 nucleus   ISO RGD:11219 1624291 MGI:MGI:3623720|PMID:16513252 RGD MGI:MGI:3623720 PMID:16513252 nucleus   ISO RGD:11219 1624291 MGI:MGI:3579756|PMID:15701640 RGD MGI:MGI:3579756 PMID:15701640 PML body   ISO RGD:731712 1624291 PMID:9448006 RGD PMID:9448006 PML body   ISS UniProtKB:P06400 1600115 GO_REF:0000024 UniProtKB GO_REF:0000024 Rb-E2F complex   ISO RGD:11219 1624291 MGI:MGI:5285162|PMID:20224733 RGD MGI:MGI:5285162 PMID:20224733 Rb-E2F complex   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 spindle   ISO RGD:11219 1624291 MGI:MGI:3056244|PMID:15509711 RGD MGI:MGI:3056244 PMID:15509711 spindle   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 transcription factor complex   ISO RGD:11219 1624291 MGI:MGI:1333653|PMID:10082561 RGD MGI:MGI:1333653 PMID:10082561 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) core promoter binding   ISO RGD:731712 1624291 PMID:15735762 RGD PMID:15735762 core promoter binding   IEA Ensembl:ENSP00000267163 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 enzyme binding   ISO RGD:11219 1624291 UniProtKB:Q9R144 RGD MGI:MGI:3653799 PMID:16616919 kinase binding   ISO RGD:731712 1624291 PMID:16286473 RGD PMID:16286473 kinase binding   ISS UniProtKB:P06400 1600115 GO_REF:0000024 UniProtKB GO_REF:0000024 phosphoprotein binding   ISO RGD:731712 1624291 UniProtKB:P06400 RGD PMID:16360038 phosphoprotein binding   IEA Ensembl:ENSP00000267163 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 protein binding   IPI RGD:621357 625751   RGD   protein binding   ISO RGD:731712 1624291 UniProtKB:P49454 RGD PMID:7651420 protein binding   ISO RGD:731712 1624291 UniProtKB:Q8VSP9 RGD PMID:19017275 protein binding   ISO RGD:731712 1624291 UniProtKB:Q9R002 RGD PMID:7890747 protein binding   ISO RGD:731712 1624291 UniProtKB:Q14653 RGD PMID:21903422 protein binding   IPI UniProtKB:O88350 69955 PMID:9697699 IntAct   protein binding   IPI UniProtKB:O09139 69955 PMID:9697699 IntAct   protein binding   IPI UniProtKB:Q8K1P7   PMID:19081374 UniProtKB PMID:19081374 protein binding   IPI UniProtKB:Q13547   PMID:19081374 UniProtKB PMID:19081374 protein binding   ISO RGD:731712 1624291 UniProtKB:P21675 RGD PMID:9858607 protein binding   ISO RGD:731712 1624291 UniProtKB:P03070 RGD PMID:9697699 protein binding   ISO RGD:731712 1624291 UniProtKB:Q86500:PRO_0000041225 RGD PMID:9608663 protein binding   ISO RGD:731712 1624291 UniProtKB:P29590-3 RGD PMID:9448006 protein binding   ISO RGD:731712 1624291 UniProtKB:P09884 RGD PMID:9395244 protein binding   ISO RGD:731712 1624291 UniProtKB:P24941 RGD PMID:8756624 protein binding   ISO RGD:731712 1624291 UniProtKB:Q3TKT4 RGD PMID:7923370 protein binding   ISO RGD:731712 1624291 UniProtKB:P42685 RGD PMID:7664264 protein binding   ISO RGD:731712 1624291 UniProtKB:P03070 RGD PMID:7592647 protein binding   ISO RGD:731712 1624291 UniProtKB:Q09028 RGD PMID:7503932 protein binding   ISO RGD:731712 1624291 UniProtKB:Q96PU4 RGD PMID:21952639 protein binding   ISO RGD:731712 1624291 UniProtKB:P04049 RGD PMID:21139044 protein binding   ISO RGD:731712 1624291 UniProtKB:P24941 RGD PMID:20871633 protein binding   ISO RGD:731712 1624291 UniProtKB:Q9NRG4 RGD PMID:20870719 protein binding   ISO RGD:731712 1624291 UniProtKB:P07197 RGD PMID:20195357 protein binding   ISO RGD:731712 1624291 UniProtKB:Q01094 RGD PMID:19249677 protein binding   ISO RGD:731712 1624291 UniProtKB:Q923E4 RGD PMID:17620057 protein binding   ISO RGD:731712 1624291 UniProtKB:Q969R5 RGD PMID:17540172 protein binding   ISO RGD:731712 1624291 UniProtKB:P30285 RGD PMID:17349581 protein binding   ISO RGD:731712 1624291 UniProtKB:P62136 RGD PMID:17274640 protein binding   ISO RGD:731712 1624291 UniProtKB:P30285 RGD PMID:17045206 protein binding   ISO RGD:731712 1624291 UniProtKB:P35232 RGD PMID:16964284 protein binding   ISO RGD:731712 1624291 UniProtKB:P52927 RGD PMID:16766265 protein binding   ISO RGD:731712 1624291 UniProtKB:P55345 RGD PMID:16616919 protein binding   ISO RGD:731712 1624291 UniProtKB:Q13574-2 RGD PMID:16286473 protein binding   ISO RGD:731712 1624291 UniProtKB:P06465 RGD PMID:16249186 protein binding   ISO RGD:731712 1624291 UniProtKB:Q9UGP4 RGD PMID:15542589 protein binding   ISO RGD:731712 1624291 UniProtKB:Q14686 RGD PMID:14645241 protein binding   ISO RGD:731712 1624291 UniProtKB:Q155P7 RGD PMID:14555653 protein binding   ISO RGD:731712 1624291 UniProtKB:P62136 RGD PMID:12434308 protein binding   ISO RGD:731712 1624291 UniProtKB:P29274 RGD PMID:11571652 protein binding   ISO RGD:731712 1624291 UniProtKB:Q9UQ80 RGD PMID:11268000 protein binding   ISO RGD:731712 1624291 UniProtKB:Q9Y6B2 RGD PMID:11073990 protein binding   ISO RGD:731712 1624291 UniProtKB:O75150 RGD PMID:10944455 protein binding   ISO RGD:731712 1624291 UniProtKB:Q9NY61 RGD PMID:10783144 protein binding   ISO RGD:731712 1624291 UniProtKB:O75832 RGD PMID:10613832 protein binding   ISO RGD:11219 1624291 UniProtKB:Q62315 RGD MGI:MGI:3589998 PMID:15870077 protein binding   ISO RGD:11219 1624291 UniProtKB:Q9CQL7 RGD MGI:MGI:3055264 PMID:15367658 protein binding   ISO RGD:11219 1624291 UniProtKB:P32114 RGD MGI:MGI:2386376 PMID:12200151 protein binding   ISO RGD:11219 1624291 UniProtKB:P53566 RGD MGI:MGI:1333653 PMID:10082561 protein binding   ISO RGD:11219 1624291 UniProtKB:Q3TKT4 RGD MGI:MGI:4887349 PMID:7923370 protein binding   ISO RGD:11219 1624291 UniProtKB:P24610|UniProtKB:Q61412 RGD MGI:MGI:1195383 PMID:9464541 protein binding   ISO RGD:11219 1624291 UniProtKB:Q155P7 RGD MGI:MGI:3843440 PMID:14555653 protein binding   ISO RGD:11219 1624291 UniProtKB:P35123 RGD MGI:MGI:4821084 PMID:11571651 protein binding   ISO RGD:11219 1624291 UniProtKB:Q80UP3 RGD MGI:MGI:3694175 PMID:16286473 protein binding   ISO RGD:11219 1624291 UniProtKB:Q9CS74 RGD MGI:MGI:4414625 PMID:19640839 protein binding   ISO RGD:11219 1624291 UniProtKB:Q3TQR0 RGD MGI:MGI:3584078 PMID:15983387 protein binding   ISO RGD:11219 1624291 UniProtKB:Q60867|UniProtKB:P12813 RGD MGI:MGI:3579756 PMID:15701640 protein binding   ISO RGD:11219 1624291 UniProtKB:Q9R002 RGD MGI:MGI:72552 PMID:7890747 protein binding   IPI RGD:3542 69955   RGD   RNA polymerase II activating transcription factor binding   ISO RGD:11219 1624291 UniProtKB:Q01094 RGD MGI:MGI:5285162 PMID:20224733 RNA polymerase II activating transcription factor binding   IEA Ensembl:ENSMUSP00000022701 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 transcription factor binding   ISO RGD:11219 1624291 UniProtKB:Q8R316 RGD MGI:MGI:3687408 PMID:9178770 transcription factor binding   ISS UniProtKB:P06400 1600115 GO_REF:0000024 UniProtKB GO_REF:0000024 transcription factor binding   ISO RGD:731712 1624291 UniProtKB:P09429 RGD PMID:19223331 transcription factor binding   ISO RGD:731712 1624291 UniProtKB:Q01094 RGD PMID:16360038 ubiquitin protein ligase binding   ISO RGD:731712 1624291 UniProtKB:O75150 RGD PMID:10944455 ubiquitin protein ligase binding   IEA Ensembl:ENSP00000267163 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) bladder cancer pathway   IEA RGD:3540 6907045   KEGG rno:05219 cell cycle pathway, mitotic   IEA RGD:3540 6907045   KEGG rno:04110 ceramide signaling pathway   ISO RGD:731712 6484113   PID PID:200119 ceramide signaling pathway   IEA RGD:3540 6907045   KEGG rno:05212 chronic myeloid leukemia pathway   IEA RGD:3540 6907045   KEGG rno:05220 glioma pathway   IEA RGD:3540 6907045   KEGG rno:05214 melanoma pathway   IEA RGD:3540 6907045   KEGG rno:05218 non-small cell lung cancer pathway   IEA RGD:3540 6907045   KEGG rno:05223 pancreatic cancer pathway   IEA RGD:3540 6907045   KEGG rno:05212 prostate cancer pathway   IEA RGD:3540 6907045   KEGG rno:05215 small cell lung cancer pathway   IEA RGD:3540 6907045   KEGG rno:05222 External Database Links KEGG Pathway Bladder cancer Cell cycle Chronic myeloid leukemia Epstein-Barr virus infection Glioma Hepatitis B HTLV-I infection Melanoma Non-small cell lung cancer Pancreatic cancer Pathways in cancer Prostate cancer Small cell lung cancer Viral carcinogenesis Pathway Interaction Database ATF-2 transcription factor network (PID:200135) Ceramide signaling pathway (PID:200119) Direct p53 effectors (PID:200120) E2F transcription factor network (PID:200032) FOXM1 transcription factor network (PID:200141) Notch-mediated HES/HEY network (PID:200228) p73 transcription factor network (PID:200017) Regulation of retinoblastoma protein (PID:200223) Disease Annotations Breast Neoplasms  (ISS) Carcinoma in Situ  (ISS) Carcinoma, Embryonal  (ISS) Carcinoma, Intraductal, Noninfiltrating  (ISS) Carcinoma, Renal Cell  (ISS) Cervical Intraepithelial Neoplasia  (ISS) Endometrial Neoplasms  (ISS) Osteosarcoma  (ISS) Ovarian Neoplasms  (ISS) Phyllodes Tumor  (ISS) Prostatic Neoplasms  (ISS) Retinoblastoma  (ISS) Seminoma  (ISS) Urinary Bladder Neoplasms  (ISS) Gene-Chemical Interaction Annotations (-)-epigallocatechin 3-gallate  (ISO) (3S,5R)-fluvastatin  (ISO) (S)-colchicine  (ISO) (S)-nicotine  (ISO) 1,3-thiazolidine-2,4-dione  (ISO) 17alpha-ethynylestradiol  (EXP,ISO) 17beta-estradiol  (ISO) 17beta-hydroxy-5alpha-androstan-3-one  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2,4-dinitrotoluene  (EXP) 2-acetamidofluorene  (EXP) 2-butoxyethanol  (ISO) 2-methylcholine  (ISO) 2-nitrofluorene  (EXP) 3-aminobenzamide  (ISO) 3-nitropropanoic acid  (EXP) 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO) 4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO) 4-hydroxynon-2-enal  (ISO) 4-hydroxyphenyl retinamide  (ISO) 5-aza-2'-deoxycytidine  (ISO) 5-fluorouracil  (ISO) 9-cis-retinoic acid  (ISO) acetylsalicylic acid  (ISO) aconitine  (ISO) aflatoxin B1  (EXP,ISO) albuterol  (ISO) all-trans-retinoic acid  (ISO) alpha-hexachlorocyclohexane  (EXP) amlodipine  (ISO) ammonium chloride  (EXP) andrographolide  (ISO) aniline  (EXP) arsenic trichloride  (ISO) auranofin  (ISO) baicalein  (ISO) benzene  (ISO) benzo[a]pyrene  (EXP,ISO) bicalutamide  (ISO) bis(2-chloroethyl) sulfide  (ISO) bisphenol A  (ISO) brassinolide  (ISO) bucladesine  (EXP,ISO) busulfan  (ISO) caffeine  (ISO) calciol  (ISO) calcitriol  (ISO) camptothecin  (ISO) capecitabine  (ISO) cefaloridine  (EXP) celecoxib  (EXP,ISO) cisplatin  (ISO) clofibric acid  (EXP) copper atom  (ISO) copper(0)  (ISO) crocidolite asbestos  (ISO) cumene  (ISO) curcumin  (ISO) daunorubicin  (ISO) DDT  (ISO) dehydroepiandrosterone  (EXP,ISO) desferrioxamine B  (ISO) dexamethasone  (EXP,ISO) diarsenic trioxide  (ISO) dibutyl phthalate  (EXP) dicoumarol  (ISO) diethylstilbestrol  (EXP,ISO) dioxygen  (ISO) docetaxel anhydrous  (ISO) doxazosin  (EXP,ISO) doxorubicin  (ISO) emodin  (ISO) ethanol  (EXP) etoposide  (ISO) everolimus  (ISO) ferulic acid  (EXP,ISO) flavanone  (ISO) gadolinium trichloride  (ISO) gamma-hexachlorocyclohexane  (EXP) genistein  (ISO) glutathione  (ISO) heparin  (ISO) heptachlor  (ISO) hydrogen peroxide  (ISO) ibuprofen  (EXP) imatinib  (ISO) indomethacin  (EXP,ISO) ketamine  (EXP) L-cysteine  (ISO) letrozole  (ISO) lithium chloride  (ISO) lovastatin  (EXP,ISO) LY294002  (ISO) lycopene  (ISO) menadione  (ISO) menaquinone  (ISO) methapyrilene  (EXP) methotrexate  (ISO) methoxsalen  (ISO) mifepristone  (ISO) mitomycin C  (ISO) myo-inositol hexakisphosphate  (ISO) N-acetyl-L-cysteine  (ISO) N-ethyl-N-nitrosourea  (EXP) N-methyl-4-phenylpyridinium  (ISO) N-methyl-N-nitrosurea  (EXP) N-nitrosodiethylamine  (EXP,ISO) N-nitrosodimethylamine  (EXP) nickel dichloride  (ISO) okadaic acid  (ISO) oleic acid  (ISO) oxaliplatin  (ISO) paclitaxel  (ISO) paracetamol  (ISO) pentachlorophenol  (EXP) pentobarbital  (EXP) phenobarbital  (EXP) phenylephrine  (EXP) phorbol 13-acetate 12-myristate  (ISO) pioglitazone  (ISO) piperonyl butoxide  (EXP) pirinixic acid  (EXP) piroxicam  (ISO) prednisone  (ISO) progesterone  (ISO) pterostilbene  (EXP) quercetin  (ISO) raloxifene  (ISO) rel-(3R,5S)-fluvastatin  (ISO) resveratrol  (EXP,ISO) romidepsin  (ISO) rosiglitazone  (ISO) S-(1,2-dichlorovinyl)-L-cysteine  (ISO) simvastatin  (EXP,ISO) sirolimus  (EXP,ISO) sulforaphane  (ISO) sulfur dioxide  (EXP) sulindac  (ISO) tamoxifen  (EXP,ISO) tazarotene  (ISO) terephthalic acid  (EXP) tert-butyl hydroperoxide  (ISO) tetrachloromethane  (EXP,ISO) theophylline  (ISO) thioacetamide  (EXP) tocopherol  (ISO) tolbutamide  (EXP) trans-resveratrol  (EXP,ISO) trichostatin A  (ISO) troglitazone  (ISO) urethane  (ISO) ursodeoxycholic acid  (ISO) valproic acid  (ISO) vinyl carbamate  (ISO) wortmannin  (ISO) zinc atom  (ISO) zinc sulfate  (ISO) zinc(0)  (ISO) Gene Ontology Annotations Biological Process cell cycle arrest  (IEA,ISO) cell division  (IEA,ISO) cell morphogenesis involved in neuron differentiation  (IEA,ISO) chromatin modification  (IEA) digestive tract development  (IEA,ISO) enucleate erythrocyte differentiation  (IEA,ISO) G1/S transition of mitotic cell cycle  (ISO) maintenance of mitotic sister chromatid cohesion  (IEA,ISO) myoblast differentiation  (ISO,ISS) negative regulation of cell cycle  (ISO) negative regulation of cell proliferation  (ISO) negative regulation of epithelial cell proliferation  (IEA,ISO) negative regulation of G1/S transition of mitotic cell cycle  (ISO) negative regulation of protein kinase activity  (ISO,ISS) negative regulation of smoothened signaling pathway  (IEA,ISO) negative regulation of transcription from RNA polymerase II promoter  (ISO) negative regulation of transcription involved in G1/S phase of mitotic cell cycle  (IEA,ISO) negative regulation of transcription, DNA-dependent  (ISO) neuron apoptotic process  (IEA,ISO) neuron differentiation  (ISO) neuron maturation  (IEA,ISO) neuron projection development  (IEA,ISO) positive regulation of macrophage differentiation  (IEA,ISO) positive regulation of mitotic metaphase/anaphase transition  (IEA,ISO) positive regulation of transcription from RNA polymerase II promoter  (IEA,ISO) protein localization to chromosome, centromeric region  (IEA,ISO) Ras protein signal transduction  (IEA,ISO) regulation of cell cycle  (ISO) regulation of cohesin localization to chromatin  (IEA,ISO) regulation of lipid kinase activity  (ISO,ISS) regulation of mitotic cell cycle  (ISO) regulation of S phase of mitotic cell cycle  (IEA) sister chromatid biorientation  (IEA,ISO) skeletal muscle cell differentiation  (ISO) striated muscle cell differentiation  (IEA,ISO) transcription, DNA-dependent  (IEA) Cellular Component nucleus  (IDA,ISO,ISS) PML body  (ISO,ISS) Rb-E2F complex  (IEA,ISO) spindle  (IEA,ISO) transcription factor complex  (ISO) Molecular Function core promoter binding  (IEA,ISO) enzyme binding  (ISO) kinase binding  (ISO,ISS) phosphoprotein binding  (IEA,ISO) protein binding  (IPI,ISO) RNA polymerase II activating transcription factor binding  (IEA,ISO) transcription factor binding  (ISO,ISS) ubiquitin protein ligase binding  (IEA,ISO) Molecular Pathway Annotations bladder cancer pathway  (IEA) cell cycle pathway, mitotic  (IEA) ceramide signaling pathway  (IEA,ISO) chronic myeloid leukemia pathway  (IEA) glioma pathway  (IEA) melanoma pathway  (IEA) non-small cell lung cancer pathway  (IEA) pancreatic cancer pathway  (IEA) prostate cancer pathway  (IEA) small cell lung cancer pathway  (IEA) External Database Links KEGG Pathway Bladder cancer Cell cycle Chronic myeloid leukemia Epstein-Barr virus infection Glioma Hepatitis B HTLV-I infection Melanoma Non-small cell lung cancer Pancreatic cancer Pathways in cancer Prostate cancer Small cell lung cancer Viral carcinogenesis Pathway Interaction Database ATF-2 transcription factor network (PID:200135) Ceramide signaling pathway (PID:200119) Direct p53 effectors (PID:200120) E2F transcription factor network (PID:200032) FOXM1 transcription factor network (PID:200141) Notch-mediated HES/HEY network (PID:200228) p73 transcription factor network (PID:200017) Regulation of retinoblastoma protein (PID:200223) References - curated 1. Bartkova J, etal., J Pathol. 2003 Jun;200(2):149-56. 2. Bettendorf O, etal., Genes Chromosomes Cancer. 2008 Jul;47(7):565-72. 3. Bieche I and Lidereau R, Mol Carcinog. 2000 Nov;29(3):151-8. 4. Daikoku T, etal., Cancer Res. 2006 Mar 1;66(5):2527-31. 5. Fujita N, etal., Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H204-12. 6. Gill RM and Hamel PA, J Cell Biol. 2000 Mar 20;148(6):1187-201. 7. GOA data from the GO Consortium 8. Haitel A, etal., Urology. 2001 Sep;58(3):477-81. 9. Jin JO, etal., Clin Genitourin Cancer. 2006 Sep;5(2):150-4. 10. Kommoss S, etal., Br J Cancer. 2007 Jan 29;96(2):306-13. 11. Kruse AJ, etal., Hum Pathol. 2008 Apr;39(4):573-8. Epub 2008 Jan 30. 12. Kuijper A, etal., Am J Clin Pathol. 2005 May;123(5):690-8. 13. MGD data from the GO Consortium 14. NCBI rat LocusLink and RefSeq merged data July 26, 2002 15. Niu Y, etal., Zhonghua Zhong Liu Za Zhi. 2004 May;26(5):290-3. 16. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 17. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 18. RGD automated data pipeline 19. RGD automated import pipeline for gene-chemical interactions 20. RGD Automated Pipelines 21. Semczuk A, etal., Arch Gynecol Obstet. 2004 Jan;269(2):104-10. Epub 2002 Nov 22. 22. Song H, etal., Cancer Res. 2006 Oct 15;66(20):10220-6. 23. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data 24. Woitach JT, etal., Nat Genet 1998 Aug;19(4):371-4. References - uncurated PubMed 10888886   11301474   12221087   12757710   14693709   15069084   15084472   15169903   15459751   15640164   15735701   16126730   16286473   16407335   16896691   17989570   18348166   18351461   18364697   18583990   18656278   18692063   18700867   19081374   19123049   19505811   20023236   20213763   20485545   20924203   21504794   7665085   8441612   8889548 RGD Disease Portals Rb1 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Cardiovascular Pathways Diabetes Pathways Biological Process Immune and Inflammatory Pathways Biological Process Neurological Pathways Obesity Pathways Biological Process Respiratory Pathways Genomics Comparative Map Data Rb1   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 15 q12   NCBI RGSC Genome Assembly v5.0 15 58,804,731 - 58,931,886 - NCBI RGSC Genome Assembly v3.4 15 53,828,881 - 53,962,099 - NCBI Rat Celera Assembly 15 48,020,828 - 48,147,805 - NCBI Genome Assembly 3.1 15 53,844,684 - 53,977,640 - NCBI RB1   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 13 29,820,961 - 29,999,081 + NCBI Human Genome Assembly HuRef 13 29,670,144 - 29,848,118 + NCBI Human Genome Assembly GRCh37 13 48,877,883 - 49,056,026 + NCBI Human Genome Assembly Build 36 13 47,775,884 - 47,954,027 + NCBI Human Cytogenetic Map 13 q14.2   NCBI Human Genome Assembly 13 47,775,911 - 47,954,023   NCBI Rb1   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 14 73,195,502 - 73,325,791 - NCBI Mouse cM Map 14 38.73   NCBI Mouse Celera Assembly 14 70,715,843 - 70,870,859 - NCBI Mouse Genome Assembly Build 37 14 73,595,309 - 73,725,598 - NCBI Mouse Genome Assembly Build 36.1 14 73,595,309 - 73,725,547 - NCBI Mouse Cytogenetic Map 14 D3   NCBI Position Markers RH94875   Map Chr Position Strand Source Rat Cytogenetic Map 15 q12   UniSTS RGSC Genome Assembly v5.0 15 58,806,133 - 58,806,359   UniSTS RGSC Genome Assembly v3.4 15 53,830,283 - 53,830,509   UniSTS Rat Celera Assembly 15 48,022,230 - 48,022,456   UniSTS PMC104404P1   Map Chr Position Strand Source Rat Cytogenetic Map 15 q12   UniSTS RGSC Genome Assembly v3.4 15 53,962,001 - 53,962,504   UniSTS M26391   Map Chr Position Strand Source Rat Cytogenetic Map 15 q12   UniSTS RGSC Genome Assembly v5.0 15 58,806,337 - 58,806,419   UniSTS RGSC Genome Assembly v3.4 15 53,830,487 - 53,830,569   UniSTS Rat Celera Assembly 15 48,022,434 - 48,022,516   UniSTS BE098816   Map Chr Position Strand Source Rat Cytogenetic Map 15 q12   UniSTS RGSC Genome Assembly v5.0 15 58,861,789 - 58,861,968   UniSTS RGSC Genome Assembly v3.4 15 53,887,416 - 53,887,595   UniSTS Rat Celera Assembly 15 48,077,756 - 48,077,935   UniSTS RH94505   Map Chr Position Strand Source Rat Cytogenetic Map 15 q12   UniSTS RGSC Genome Assembly v5.0 15 58,805,545 - 58,805,693   UniSTS RGSC Genome Assembly v5.0 15 58,805,499 - 58,805,693   UniSTS RGSC Genome Assembly v3.4 15 53,829,649 - 53,829,843   UniSTS RGSC Genome Assembly v3.4 15 53,829,695 - 53,829,843   UniSTS Rat Celera Assembly 15 48,021,642 - 48,021,790   UniSTS Rat Celera Assembly 15 48,021,596 - 48,021,790   UniSTS RH138574   Map Chr Position Strand Source Rat Cytogenetic Map 15 p11   UniSTS Rat Cytogenetic Map 15 q12   UniSTS RGSC Genome Assembly v5.0 15 58,850,398 - 58,850,536   UniSTS RGSC Genome Assembly v3.4 15 53,875,791 - 53,875,929   UniSTS Rat Celera Assembly 15 48,066,406 - 48,066,544   UniSTS QTLs in Region (RGSC Genome Assembly v3.4) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 2298549 Neuinf12 Neuroinflammation QTL 12 2.2 Neuroinflammation 15 1 61161186 Rat 1582251 Gluco24 Glucose level QTL 24 3.2 .0008 Glucose level uptake 15 10138595 55138595 Rat 2317750 Glom26 Glomerulus QTL 26 4.3 Renal pathology urine protein level 15 14072029 71533203 Rat 2293688 Bss29 Bone structure and strength QTL 29 5.31 .0001 Bone structure 15 16042557 61042557 Rat 2300167 Bmd63 Bone mineral density QTL 63 5.9 .0001 Bone mineral density 15 16042557 61042557 Rat 2300173 Bmd62 Bone mineral density QTL 62 12.8 .0001 Bone mineral density 15 16042557 61042557 Rat 5685002 Bss103 Bone structure and strength QTL 103 2.8 Bone strength work to fail 15 16365832 61365832 Rat 631273 Cati2 Cataract Ihara QTL 2 .001 Cataract susceptibility time of onset 15 16458810 61458810 Rat 61424 Scl1 Serum cholesterol level QTL 1 7.7 .001 Lipid level cholesterol 15 18710622 87898700 Rat 1331729 Rf42 Renal function QTL 42 3.071 Renal function renal blood flow 15 19348148 80362100 Rat 1578660 Bss19 Bone structure and strength QTL 19 4.3 Bone structure femoral neck trabecular area 15 25506124 106177917 Rat 1578646 Bmd18 Bone mineral density QTL 18 5.2 Bone mineral density femoral neck trabecular vBMD 15 25506124 106177917 Rat 1578647 Bmd17 Bone mineral density QTL 17 4 Bone mineral density femoral neck total vBMD 15 25506124 106177917 Rat 1582242 Gluco28 Glucose level QTL 28 3.3 .0008 Glucose level uptake 15 32638412 89569864 Rat 1582244 Bw79 Body weight QTL 79 4 .0002 Body fat amount adiposity index 15 32638412 89569864 Rat 1582214 Stl21 Serum triglyceride level QTL 21 3.1 .022 Lipid level triglyceride 15 32638412 89569864 Rat 1582227 Gluco30 Glucose level QTL 30 3.6 .0003 Glucose level uptake 15 32638412 89569864 Rat 1582228 Epfw3 Epididymal fat weight QTL 3 4.1 .0002 Epididymal fat weight 15 32638412 89569864 Rat 2293686 Bmd36 Bone mineral density QTL 36 7.4 .0001 Bone mineral density 15 38542355 78048493 Rat 2293691 Bmd37 Bone mineral density QTL 37 6.6 .0001 Bone mineral density 15 38542355 78048493 Rat 1598828 Glom14 Glomerulus QTL 14 2.5 Renal pathology glomerular injury score 15 40091127 85091127 Rat 1300144 Rf23 Renal function QTL 23 3.61 Renal function salt-loaded renal vascular resistance 15 45870097 106177917 Rat 2302780 MAMTS3_H Mammary tumor susceptibility QTL 3 (human) 2.51 Mammary tumor susceptibility 8 47636303 92636303 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NM_017045 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AABR06084052 (Get FASTA) Search GEO for Microarray Profiles   AABR06084053 (Get FASTA) Search GEO for Microarray Profiles   AABR06084054 (Get FASTA) Search GEO for Microarray Profiles   AABR06084055 (Get FASTA) Search GEO for Microarray Profiles   AABR06084056 (Get FASTA) Search GEO for Microarray Profiles   AAHX01083846 (Get FASTA) Search GEO for Microarray Profiles   AAHX01083847 (Get FASTA) Search GEO for Microarray Profiles   AAHX01083848 (Get FASTA) Search GEO for Microarray Profiles   AAHX01083849 (Get FASTA) Search GEO for Microarray Profiles   BE098611 (Get FASTA) Search GEO for Microarray Profiles   CH473951 (Get FASTA) Search GEO for Microarray Profiles   D25233 (Get FASTA) Search GEO for Microarray Profiles   L07126 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_017045 RefSeq Status: VALIDATED Type: CODING Protein Acc Id: NP_058741 Position: Map Chr Position Strand Source RGSC Genome Assembly v5.0 15 58,804,731 - 58,931,886 - NCBI RGSC Genome Assembly v3.4 15 53,828,881 - 53,962,099 - RGD Rat Celera Assembly 15 48,020,828 - 48,147,805 - RGD Protein Sequences Protein RefSeqs NP_058741 (Get FASTA) GenBank Protein AAA42090 (Get FASTA)   BAA04958 (Get FASTA)   EDM02266 (Get FASTA)   P33568 (Get FASTA) Strain Variation Strain Sequence Variants ACI/Eur (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 ACI/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN-Lx (ICL) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: SOLID Secondary Analysis: BWA, GATK, Samtools Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: MC-A654-5QB00 BN-Lx (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/NHsdMcwi (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/SsN (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Buf/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) COP/Crl (MCW & UW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Univiersity of Wisconsin (Jim Shull) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 Breeder: Charles River Grant Information: NIH (CA77876) F344/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHH/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 FHH/EurMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHL/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 GH/OmrMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 LE/Stm (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Dr. Tadao Serikawa, Kyoto Japan. Grant Information: EURATRANS (HEALTH-F4-2010-241504) M520/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) MR/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHR/Olalpcv (ICL) Visual CSV TAB Printer Sequenced By: Imperial College London (Dr Timothy Aitman) University of British Columbia (Dr. Steven Jones) Platform: Illumina Hi-seq 2000 and GAII Secondary Analysis: BWA, GATK Breeder: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague Grant Information: LSHG-CT-2005-019015, HEALTH-F4-2010-241504 SHR/Olalpcv (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: Illumina Secondary Analysis: GATK Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHRSP/Gcrc (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruch Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: University of Glasgow, Anna Dominiczak Grant Information: EURATRANS (HEALTH-F4-2010-241504) SR/JrHsd (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Breeder: Harlan SS/JrHsdMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Grant Information: R01 HL089930 SS/JrHsdMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) WKY/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) WN/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSRNOG00000016029 ENTREZGENE Ensembl Protein ENSRNOP00000021752 ENTREZGENE Ensembl Transcript ENSRNOT00000021752 ENTREZGENE Entrez Gene 24708 ENTREZGENE Gene3D-CATH Cyclin_related UniProtKB/Swiss-Prot Germonline ENSRNOG00000016029 UniProtKB/Swiss-Prot HomoloGene Group ID 272 ENTREZGENE InterPro Cyclin_related UniProtKB/Swiss-Prot   DUF3452_retinoblatoma-assoc UniProtKB/Swiss-Prot   RB_A UniProtKB/Swiss-Prot   Rb_associated UniProtKB/Swiss-Prot   RB_B UniProtKB/Swiss-Prot   Rb_C UniProtKB/Swiss-Prot IPI IPI00192561 UniProtKB/Swiss-Prot KEGG Report rno:24708 ENTREZGENE, UniProtKB/Swiss-Prot PANTHER Rb_associated UniProtKB/Swiss-Prot Pfam DUF3452 UniProtKB/Swiss-Prot   RB_A UniProtKB/Swiss-Prot   RB_B UniProtKB/Swiss-Prot   Rb_C UniProtKB/Swiss-Prot PharmGKB RB1 RGD SMART CYCLIN UniProtKB/Swiss-Prot Superfamily-SCOP Cyclin_like UniProtKB/Swiss-Prot TIGR TC230434 UniGene Rn.55115 ENTREZGENE UniProt RB_RAT UniProtKB/Swiss-Prot Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2002-06-10 Rb1  Retinoblastoma 1 (including osteosarcoma)      Symbol and Name status set to approved 1490 APPROVED RGD Curation Notes Note Type Note Reference gene_disease human homolog is inactivated in many tumors 734501

More on Rb1 Entrez Gene Ensembl Gene Genome Browser NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 3540 Created: 2000-05-25 Species: Rattus norvegicus Last Modified: 2013-04-16 Status: ACTIVE