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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3increases expressionEXP 6480464CTDFenofibrate results in increased expression of NR1I3 mRNAPMID:19118567 PMID:32741897
Nr1i3affects localizationISONr1i3 (Mus musculus)6480464CTDFenofibrate affects the localization of NR1I3 proteinPMID:17962186
Nr1i3increases activityISONr1i3 (Mus musculus)6480464CTDFenofibrate results in increased activity of NR1I3 proteinPMID:30203046
Nr1i3multiple interactionsISONR1I3 (Homo sapiens)6480464CTD[Oleic Acid co-treated with Fenofibrate] results in increased expression of NR1I3 mRNA; Fenofibrate binds to and results in increased activity of NR1I3 protein alternative formPMID:24534255 PMID:31312845
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