Gene: Edn1 (endothelin 1)  Rattus norvegicus Symbol: Edn1 Name: endothelin 1 Description: ENCODES a protein that exhibits endothelin A receptor binding; endothelin B receptor binding; cytokine activity (ortholog); INVOLVED IN cell growth; cellular response to interleukin-1; cellular response to tumor necrosis factor; PARTICIPATES IN inflammatory response pathway; endothelin signaling pathway; hypoxia inducible factor pathway; ASSOCIATED WITH Albuminuria; Brain Ischemia; Bronchopulmonary Dysplasia; FOUND IN extracellular space; cytoplasm (ortholog); INTERACTS WITH (+)-catechin; (R)-noradrenaline; 1,3-dinitrobenzene Type: protein-coding RefSeq Status: VALIDATED Also known as: endothelin-1; ET-1; Et1; PPET1; preproendothelin-1 Orthologs: Homo sapiens : EDN1 (endothelin 1)  HGNC Is Marker For: Strains:   F344.OLETF-(D17Mgh4-Edn1)/Tj   QTLs:   Niddm32   Latest Assembly: RGSC Genome Assembly v3.4 Position: Map Chr Position Strand Source Rat Cytogenetic Map 17 p12   NCBI RGSC Genome Assembly v5.0 17 24,118,009 - 24,124,009 - NCBI RGSC Genome Assembly v3.4 17 28,303,886 - 28,309,775 - NCBI Rat Celera Assembly 17 22,134,975 - 22,140,901 - NCBI Genome Assembly 3.1 17 28,306,726 - 28,312,616 - NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Acute Kidney Injury   ISS RGD:10499 4144852 mRNA, protein:increased expression:kidney (mouse) RGD   Albuminuria   IEP   4144838 protein:increased expression:renal papilla (rat) RGD   Asthma   ISS RGD:730848 4144895 Severe Persistent Allergic Asthma; more ... RGD   Asthma   ISS RGD:730848 4144869 DNA:transition:intron:g.4124T>C (human) RGD   Brain Ischemia   IEP   4144887 protein:increased expression:cerebral cortex (rat) RGD   Bronchitis, Chronic   ISS RGD:10499 4145074 Chronic Allergic Airway Inflammation; more ... RGD   Bronchopulmonary Dysplasia   IEP   4144841 protein:increased expression:lung (rat) RGD   Cardiomyopathy, Hypertrophic   IEP   2302065 associated with Diabetes Mellitus, Experimental; more ... RGD   Coronary Artery Disease   ISS RGD:730848 4144886 protein:increased expression:atherosclerotic lesions (human) RGD   Cystic Fibrosis   ISS RGD:730848 4145062 protein:increased expression:sputum (human) RGD   Diabetes Mellitus, Experimental   IEP   2313282 mRNA:increased expression:heart, kidney, retina (rat) RGD   Diabetes Mellitus, Type 1   ISS RGD:730848 4144835 protein:increased secretion:plasma (human) RGD   Diabetes Mellitus, Type 2   IEP   2313280 protein:increased expression:mesenteric artery RGD   Diabetes Mellitus, Type 2   ISS RGD:730848 2313278 mRNA:increased expression:blood vessel endothelial cell RGD   Diabetic Nephropathies   ISS RGD:730848 2313284 associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased secretion:plasma (human) RGD   Diabetic Retinopathy   ISS RGD:730848 2313281 associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:exon:p.K198N (human) RGD   Diabetic Retinopathy   ISS RGD:730848 2313279 associated with Diabetes Mellitus, Insulin-Dependent;protein:increased secretion:plasma RGD   Dyspnea   ISS RGD:730848 4145071 protein:increased secretion:urine (human) RGD   Erectile Dysfunction   IEP   2292142 protein:increased expression:plasma RGD   Glomerulonephritis, Membranoproliferative   IEP   4144848 mRNA, protein:increased expression:glomerulus (rat) RGD   Heart Diseases   IEP   4892599 associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:heart left ventricle, plasma RGD   Heart Failure Severity ISS RGD:730848 4144845 protein:increased secretion:plasma (human) RGD   Hepatopulmonary Syndrome   IEP   4144891 protein:increased secretion:liver, plasma (rat) RGD   Hypercapnia   IEP   4144885 protein:increased secretion:plasma (rat) RGD   Hypercapnia   ISS RGD:10499 4144902   RGD   Hyperoxia   IEP   4144857 protein:altered expression:lung (rat) RGD   Hypertension   ISS RGD:10499 734913   RGD   Hypertension   IEP   4144829 protein:increased secretion:plasma (rat) RGD   Hypertension   ISS RGD:730848 2313283 associated with Diabetic Nephropathies;protein:increased secretion:plasma RGD   Hypertension   ISS RGD:730848 1625065 DNA:polymorphism:exon:p.K198N (human) RGD   Hypertension, Portal   IED   4892595   RGD   Hypertension, Pregnancy-Induced No_Association ISS RGD:730848 4145070 DNA:transversion:exon:p.K198N rs5370 (human) RGD   Hypertension, Pregnancy-Induced   ISS RGD:730848 4145063 DNA:transversion:exon:p.K198N rs5370 (human) RGD   Hypertension, Pulmonary   IEP   4144128 mRNA:increased expression:lung (rat) RGD   Hypertension, Pulmonary   ISS RGD:730848 4144865 associated with Pulmonary Disease, Chronic Obstructive; more ... RGD   Hypertension, Pulmonary   ISS RGD:730848 4144882 Hypertension, Portopulmonary; more ... RGD   Hypertension, Pulmonary   ISS RGD:10499 4144877 Hypertension, Heritable Pulmonary Artery; more ... RGD   Hypogonadism   IEP   4833436 mRNA, protein:decreased expression:testis (rat) RGD   Hypotension   ISS RGD:10499 4144881   RGD   Kidney Failure, Chronic   IEP   4144849 mRNA:increased expression:kidney (rat) RGD   Liver Cirrhosis   IEP   4144843 mRNA:increased expression:liver (rat) RGD   Mandibulofacial Dysostosis   ISS RGD:10499 734913   RGD   Myocardial Infarction Severity ISS RGD:730848 4144880 protein:increased secretion:plasma (human) RGD   Myocardial Reperfusion Injury   IEP   4892580   RGD   Neoplasm Metastasis   ISS RGD:10499 734914   RGD   Nephrosis   IEP   4144855 mRNA:increased expression:glomerulus (rat) RGD   Obesity   ISS RGD:730848 1625065 DNA:polymorphism:exon:p.K198N (human) RGD   Optic Nerve Injuries   IEP   4892579 protein:increased expression:retina RGD   Ovarian Neoplasms   ISS RGD:730848 4144954 mRNA, protein:increased expression:ovarian tumor (human) RGD   Pierre Robin Syndrome   ISS RGD:10499 734913   RGD   Pneumonia Severity ISS RGD:730848 4144879 protein:increased secretion:plasma (human) RGD   Pneumonia, Aspiration   IEP   4145069 protein:increased secretion:plasma (rat) RGD   Polycystic Kidney, Autosomal Dominant   ISS RGD:730848 4144854 mRNA, protein:increased expression:kidney (human) RGD   Pulmonary Disease, Chronic Obstructive   ISS RGD:730848 4145062 protein:increased expression:sputum (human) RGD   Pulmonary Disease, Chronic Obstructive   ISS RGD:730848 4144868 DNA:insertion, transversion:5' utr, exon:c.138_139insA, p.K198N (human) RGD   Pulmonary Embolism Severity IEP   4144858 protein:increased secretion:plasma (rat) RGD   Pulmonary Fibrosis   IEP   4144892 protein:increased expression:lung, airway epithelium, leukocyte (rat) RGD   Pulmonary Fibrosis   ISS RGD:730848 4144889 Cryptogenic Fibrosing Alveolitis; more ... RGD   Pulmonary Fibrosis   ISS RGD:730848 4144866 associated with Scleroderma, Systemic; more ... RGD   Renal Insufficiency Onset IEP   4144130 protein:increased expression:kidney (rat) RGD   Reperfusion Injury   IEP   4892577   RGD   Respiratory Distress Syndrome, Adult   IEP   4145073 protein:increased secretion:plasma (rat) RGD   Respiratory Distress Syndrome, Adult   ISS RGD:730848 4145079 protein:increased secretion:plasma (human) RGD   Respiratory Insufficiency   ISS RGD:10499 734913   RGD   Scleroderma, Systemic   ISS RGD:730848 4145072 protein:increased secretion:plasma (human) RGD   Sleep Apnea, Obstructive   ISS RGD:730848 4145075 DNA:polymorphism:exon:p.K198N (human) RGD   Sleep Apnea, Obstructive   IEP   4145067 protein:increased expression:myocardium (rat) RGD   Sleep Apnea, Obstructive   ISS RGD:730848 4144901 protein:increased secretion:plasma (human) RGD   stress related behavior   IEP   4144859 protein:increased secretion:plasma (rat) RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (+)-catechin multiple interactions EXP   6480464 Catechin inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]; more ... CTD PMID:20977430 (+)-catechin multiple interactions ISO   6480464 [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA CTD PMID:16806235 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:730848 6480464 epigallocatechin gallate inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA] CTD PMID:20021702 (-)-epigallocatechin 3-gallate decreases expression ISO RGD:730848 6480464 epigallocatechin gallate results in decreased expression of EDN1 mRNA CTD PMID:20021702 (R)-mevalonic acid multiple interactions ISO RGD:730848 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]; more ... CTD PMID:18390205 (R)-noradrenaline multiple interactions EXP   6480464 BQ 610 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]; more ... CTD PMID:14759557 (R)-noradrenaline increases expression EXP   6480464 Norepinephrine results in increased expression of EDN1 mRNA CTD PMID:11435416 (R)-noradrenaline increases activity EXP   6480464 Norepinephrine results in increased activity of EDN1 promoter CTD PMID:11435416 (R)-noradrenaline multiple interactions EXP   6480464 Metoprolol inhibits the reaction [Norepinephrine results in increased expression of EDN1 mRNA] CTD PMID:11435416 (R)-noradrenaline decreases secretion EXP   6480464 EDN1 protein results in decreased secretion of Norepinephrine CTD PMID:12184995 (R)-noradrenaline increases secretion EXP   6480464 EDN1 protein results in increased secretion of Norepinephrine CTD PMID:14759557 (R)-noradrenaline multiple interactions EXP   6480464 [EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine CTD PMID:16023617 (R)-noradrenaline multiple interactions EXP   6480464 BQ 788 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]; more ... CTD PMID:12184995 1,3-dinitrobenzene increases expression EXP   6480464 3-dinitrobenzene results in increased expression of EDN1 mRNA CTD PMID:22841810 11-deoxycorticosterone multiple interactions EXP   6480464 Mibefradil inhibits the reaction [[Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 mRNA] CTD PMID:8934362 11-deoxycorticosterone increases expression EXP   6480464 Desoxycorticosterone results in increased expression of EDN1 CTD PMID:12600921 11-deoxycorticosterone increases expression EXP   6480464 Desoxycorticosterone results in increased expression of EDN1 protein CTD PMID:16054168 11-deoxycorticosterone multiple interactions EXP   6480464 Clofibrate inhibits the reaction [Desoxycorticosterone results in increased expression of EDN1 protein] CTD PMID:16054168 11-deoxycorticosterone multiple interactions EXP   6480464 [Sodium Chloride, Dietary co-treated with Desoxycorticosterone] results in increased expression of EDN1 protein CTD PMID:1860718 17alpha-ethynylestradiol affects expression ISO   6480464 Ethinyl Estradiol affects the expression of EDN1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression ISO   6480464 Ethinyl Estradiol results in increased expression of EDN1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression EXP   6480464 Ethinyl Estradiol affects the expression of EDN1 mRNA CTD PMID:20170705 17alpha-ethynylestradiol multiple interactions ISO   6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of EDN1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:730848 6480464 Ethinyl Estradiol affects the expression of EDN1 mRNA CTD PMID:20170705 17beta-estradiol multiple interactions ISO RGD:730848 6480464 Estradiol promotes the reaction [[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA] CTD PMID:19943105 17beta-estradiol decreases expression ISO RGD:730848 6480464 Estradiol results in decreased expression of EDN1 mRNA CTD PMID:19167446 more ... 17beta-estradiol decreases expression ISO RGD:730848 6480464 Estradiol results in decreased expression of EDN1 mRNA CTD PMID:20106945 PMID:21632981 17beta-estradiol increases expression ISO RGD:730848 6480464 Estradiol results in increased expression of EDN1 mRNA CTD PMID:19943105 PMID:19153601 17beta-estradiol increases expression ISO RGD:730848 6480464 Estradiol results in increased expression of EDN1 mRNA CTD PMID:19153601 PMID:19943105 17beta-estradiol multiple interactions ISO RGD:730848 6480464 Dydrogesterone affects the reaction [Estradiol results in decreased expression of EDN1 protein] CTD PMID:12385860 17beta-estradiol decreases expression ISO RGD:730848 6480464 Estradiol results in decreased expression of EDN1 protein CTD PMID:12385860 17beta-estradiol decreases expression ISO RGD:730848 6480464 Estradiol results in decreased expression of EDN1 mRNA CTD PMID:20106945 1D-myo-inositol 1,4,5-trisphosphate multiple interactions EXP   6480464 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate] CTD PMID:11911850 1D-myo-inositol 1,4,5-trisphosphate multiple interactions EXP   6480464 Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate] CTD PMID:1443220 1D-myo-inositol 1,4,5-trisphosphate increases chemical synthesis EXP   6480464 EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate CTD PMID:11911850 1D-myo-inositol 1,4,5-trisphosphate increases abundance EXP   6480464 EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate CTD PMID:1443220 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] decreases expression ISO RGD:730848 6480464 nebivolol results in decreased expression of EDN1 mRNA CTD PMID:11078433 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] decreases secretion ISO RGD:730848 6480464 nebivolol results in decreased secretion of EDN1 protein CTD PMID:11078433 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO   6480464 Tetrachlorodibenzodioxin results in increased expression of EDN1 mRNA CTD PMID:17975115 PMID:16120747 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP   6480464 Tetrachlorodibenzodioxin results in decreased expression of EDN1 mRNA CTD PMID:21724226 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO   6480464 Tetrachlorodibenzodioxin affects the expression of EDN1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP   6480464 Tetrachlorodibenzodioxin affects the expression of EDN1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO   6480464 Tetrachlorodibenzodioxin results in increased expression of EDN1 mRNA CTD PMID:16120747 PMID:17975115 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO   6480464 Tetrachlorodibenzodioxin results in decreased expression of EDN1 mRNA CTD PMID:17942748 PMID:19933214 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO   6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of EDN1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO   6480464 Tetrachlorodibenzodioxin results in decreased expression of EDN1 mRNA CTD PMID:19933214 PMID:17942748 2-butoxyethanol increases expression ISO   6480464 n-butoxyethanol results in increased expression of EDN1 mRNA CTD PMID:19812364 3',5'-cyclic GMP multiple interactions EXP   6480464 Puromycin Aminonucleoside inhibits the reaction [EDN1 protein results in increased abundance of Cyclic GMP] CTD PMID:12972712 3',5'-cyclic GMP increases abundance EXP   6480464 EDN1 protein results in increased abundance of Cyclic GMP CTD PMID:12972712 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine multiple interactions EXP   6480464 Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA]; more ... CTD PMID:9175058 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression EXP   6480464 Puromycin Aminonucleoside results in increased expression of EDN1 mRNA CTD PMID:9175058 more ... 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression EXP   6480464 Puromycin Aminonucleoside results in increased expression of EDN1 mRNA CTD PMID:12972712 more ... 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expression EXP   6480464 Puromycin Aminonucleoside results in increased expression of EDN1 mRNA CTD PMID:12972712 more ... 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine multiple interactions EXP   6480464 Puromycin Aminonucleoside inhibits the reaction [EDN1 protein results in increased abundance of Cyclic GMP] CTD PMID:12972712 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine multiple interactions EXP   6480464 Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:7756592 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO   6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of EDN1 mRNA CTD PMID:16054899 3H-1,2-dithiole-3-thione increases expression EXP   6480464 1,2-dithiol-3-thione results in increased expression of EDN1 mRNA CTD PMID:19162173 4-hydroxynon-2-enal decreases expression ISO   6480464 4-hydroxy-2-nonenal results in decreased expression of EDN1 mRNA CTD PMID:19191707 5-fluorouracil increases expression ISO RGD:730848 6480464 Fluorouracil results in increased expression of EDN1 protein CTD PMID:1606078 5-fluorouracil increases expression ISO RGD:730848 6480464 Fluorouracil results in increased expression of EDN1 mRNA CTD PMID:19098008 5-formyltetrahydrofolic acid increases expression ISO   6480464 Leucovorin results in increased expression of EDN1 mRNA; more ... CTD PMID:16925845 6alpha-methylprednisolone multiple interactions EXP   6480464 Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:7756592 8-bromo-3',5'-cyclic GMP multiple interactions EXP   6480464 8-bromocyclic GMP inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein] CTD PMID:16023617 acetylcholine decreases response to substance EXP   6480464 EDN1 protein results in decreased susceptibility to Acetylcholine CTD PMID:20977430 acetylcholine multiple interactions EXP   6480464 Catechin inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]; more ... CTD PMID:20977430 aflatoxin B1 affects expression ISO RGD:730848 6480464 Aflatoxin B1 affects the expression of EDN1 protein CTD PMID:20106945 aflatoxin B1 increases expression ISO RGD:730848 6480464 Aflatoxin B1 results in increased expression of EDN1 mRNA CTD PMID:21632981 PMID:21641981 aflatoxin B1 increases expression ISO RGD:730848 6480464 Aflatoxin B1 results in increased expression of EDN1 mRNA CTD PMID:21641981 aldosterone increases expression EXP   6480464 Aldosterone results in increased expression of EDN1 protein CTD PMID:18660453 aldosterone multiple interactions EXP   6480464 [EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 all-trans-retinoic acid multiple interactions ISO RGD:730848 6480464 [Tretinoin co-treated with Ascorbic Acid] results in increased expression of EDN1 mRNA CTD PMID:16443354 all-trans-retinoic acid increases expression ISO RGD:730848 6480464 Tretinoin results in increased expression of EDN1 mRNA CTD PMID:15498508 all-trans-retinoic acid decreases expression EXP   6480464 Tretinoin results in decreased expression of EDN1 protein CTD PMID:16619265 all-trans-retinoic acid decreases expression ISO   6480464 Tretinoin results in decreased expression of EDN1 protein CTD PMID:17551590 amlodipine affects expression ISO RGD:730848 6480464 Amlodipine affects the expression of EDN1 protein CTD PMID:11369837 ammonium chloride affects expression EXP   6480464 Ammonium Chloride affects the expression of EDN1 mRNA CTD PMID:16483693 ampicillin increases expression ISO RGD:730848 6480464 Ampicillin results in increased expression of EDN1 mRNA CTD PMID:21632981 apocynin multiple interactions EXP   6480464 acetovanillone inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine] CTD PMID:20977430 apocynin multiple interactions EXP   6480464 acetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:22431579 apocynin multiple interactions ISO   6480464 acetovanillone inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA] CTD PMID:17391658 arsenite(3-) affects expression ISO   6480464 arsenite affects the expression of EDN1 mRNA CTD PMID:15738583 asbestos decreases expression ISO RGD:730848 6480464 Asbestos results in decreased expression of EDN1 mRNA CTD PMID:22398240 atenolol affects response to substance ISO RGD:730848 6480464 EDN1 gene polymorphism affects the susceptibility to Atenolol CTD PMID:15188945 atropine multiple interactions ISO RGD:730848 6480464 EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] CTD PMID:12906840 benazepril decreases expression EXP   6480464 benazepril results in decreased expression of EDN1 protein; more ... CTD PMID:16191423 benazepril multiple interactions EXP   6480464 [valsartan co-treated with benazepril] results in decreased expression of EDN1 protein CTD PMID:11136700 benazepril increases activity EXP   6480464 benazepril results in increased activity of EDN1 protein CTD PMID:7528292 benzo[a]pyrene decreases expression ISO RGD:730848 6480464 Benzo(a)pyrene results in decreased expression of EDN1 mRNA CTD PMID:20106945 benzo[a]pyrene increases expression ISO RGD:730848 6480464 Benzo(a)pyrene results in increased expression of EDN1 mRNA CTD PMID:16269432 more ... benzo[a]pyrene affects expression ISO RGD:730848 6480464 Benzo(a)pyrene affects the expression of EDN1 mRNA CTD PMID:21632981 benzo[a]pyrene increases expression ISO RGD:730848 6480464 Benzo(a)pyrene results in increased expression of EDN1 mRNA CTD PMID:21871943 PMID:22316170 benzo[a]pyrene decreases expression ISO   6480464 Benzo(a)pyrene results in decreased expression of EDN1 mRNA CTD PMID:21569818 benzo[a]pyrene increases expression ISO RGD:730848 6480464 Benzo(a)pyrene results in increased expression of EDN1 mRNA CTD PMID:21871943 benzo[a]pyrene multiple interactions ISO   6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to EDN1 promoter] CTD PMID:19654925 bezafibrate decreases expression ISO RGD:730848 6480464 Bezafibrate results in decreased expression of EDN1 protein CTD PMID:11330878 bezafibrate multiple interactions EXP   6480464 Bezafibrate inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA] CTD PMID:12967931 bis(2-ethylhexyl) phthalate affects expression EXP   6480464 Diethylhexyl Phthalate affects the expression of EDN1 mRNA CTD PMID:20920545 bisphenol A affects expression ISO RGD:730848 6480464 bisphenol A affects the expression of EDN1 mRNA CTD PMID:20170705 bosentan decreases activity EXP   6480464 bosentan results in decreased activity of EDN1 protein CTD PMID:10961375 bosentan decreases expression EXP   6480464 bosentan results in decreased expression of EDN1 protein CTD PMID:16431896 bosentan multiple interactions EXP   6480464 bosentan binds to and results in decreased activity of EDN1 protein CTD PMID:10474778 bosentan multiple interactions ISO RGD:730848 6480464 EDN1 protein inhibits the reaction [bosentan results in decreased expression of CXADR mRNA] CTD PMID:20392896 bosentan multiple interactions EXP   6480464 bosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA] CTD PMID:20967148 cadmium dichloride increases expression ISO RGD:730848 6480464 Cadmium Chloride results in increased expression of EDN1 mRNA CTD PMID:18560533 cadmium dichloride multiple interactions ISO RGD:730848 6480464 TNF affects the reaction [Cadmium Chloride results in increased expression of EDN1 mRNA] CTD PMID:18560533 caffeine increases activity EXP   6480464 Caffeine results in increased activity of EDN1 protein CTD PMID:1860718 calcitriol decreases expression ISO RGD:730848 6480464 Calcitriol results in decreased expression of EDN1 mRNA CTD PMID:16002434 calcitriol multiple interactions ISO RGD:730848 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of EDN1 mRNA CTD PMID:21592394 calcitriol increases expression ISO RGD:730848 6480464 Calcitriol results in increased expression of EDN1 mRNA CTD PMID:21592394 calcium atom multiple interactions ISO RGD:730848 6480464 Propofol inhibits the reaction [EDN1 protein affects the transport of Calcium] CTD PMID:9138053 calcium atom affects localization EXP   6480464 EDN1 protein affects the localization of Calcium CTD PMID:12628492 calcium atom multiple interactions EXP   6480464 Heparin inhibits the reaction [EDN1 protein results in increased abundance of Calcium] CTD PMID:1443220 calcium atom increases abundance EXP   6480464 EDN1 protein results in increased abundance of Calcium CTD PMID:1443220 calcium atom multiple interactions EXP   6480464 EDN1 protein affects the abundance of and affects the localization of Calcium; more ... CTD PMID:12821678 calcium atom increases uptake ISO   6480464 EDN1 protein results in increased uptake of Calcium CTD PMID:11425647 calcium atom multiple interactions ISO   6480464 EDN1 protein affects the localization of and affects the abundance of Calcium CTD PMID:11425647 calcium atom multiple interactions EXP   6480464 carvedilol inhibits the reaction [EDN1 protein results in increased import of and results in increased abundance of Calcium] CTD PMID:14711191 calcium atom affects transport ISO RGD:730848 6480464 EDN1 protein affects the transport of Calcium CTD PMID:9138053 calcium(0) multiple interactions ISO RGD:730848 6480464 Propofol inhibits the reaction [EDN1 protein affects the transport of Calcium] CTD PMID:9138053 calcium(0) affects localization EXP   6480464 EDN1 protein affects the localization of Calcium CTD PMID:12628492 calcium(0) multiple interactions EXP   6480464 Heparin inhibits the reaction [EDN1 protein results in increased abundance of Calcium] CTD PMID:1443220 calcium(0) increases abundance EXP   6480464 EDN1 protein results in increased abundance of Calcium CTD PMID:1443220 calcium(0) multiple interactions EXP   6480464 EDN1 protein affects the abundance of and affects the localization of Calcium; more ... CTD PMID:12821678 calcium(0) increases uptake ISO   6480464 EDN1 protein results in increased uptake of Calcium CTD PMID:11425647 calcium(0) multiple interactions ISO   6480464 EDN1 protein affects the localization of and affects the abundance of Calcium CTD PMID:11425647 calcium(0) multiple interactions EXP   6480464 carvedilol inhibits the reaction [EDN1 protein results in increased import of and results in increased abundance of Calcium] CTD PMID:14711191 calcium(0) affects transport ISO RGD:730848 6480464 EDN1 protein affects the transport of Calcium CTD PMID:9138053 capsaicin decreases activity ISO RGD:730848 6480464 EDN1 protein results in decreased activity of Capsaicin CTD PMID:9932722 capsaicin multiple interactions ISO RGD:730848 6480464 EDN1 protein promotes the reaction [Capsaicin results in increased activity of TRPV1 protein] CTD PMID:19429182 capsaicin multiple interactions ISO RGD:730848 6480464 FR 139317 inhibits the reaction [EDN1 protein results in decreased activity of Capsaicin] CTD PMID:9932722 carbon atom decreases activity EXP   6480464 Carbon analog results in decreased activity of EDN1 protein CTD PMID:20214918 carbon monoxide increases expression ISO   6480464 Carbon Monoxide results in increased expression of EDN1 mRNA CTD PMID:20197249 carbon monoxide increases expression EXP   6480464 Carbon Monoxide results in increased expression of EDN1 protein; more ... CTD PMID:11781074 carvedilol decreases secretion ISO RGD:730848 6480464 carvedilol results in decreased secretion of EDN1 protein CTD PMID:11078433 carvedilol decreases expression EXP   6480464 carvedilol results in decreased expression of EDN1 mRNA CTD PMID:18971572 carvedilol multiple interactions EXP   6480464 carvedilol inhibits the reaction [EDN1 protein results in increased import of and results in increased abundance of Calcium] CTD PMID:14711191 carvedilol decreases expression ISO RGD:730848 6480464 carvedilol results in decreased expression of EDN1 mRNA; more ... CTD PMID:9500873 carvedilol multiple interactions ISO RGD:730848 6480464 carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]; more ... CTD PMID:16428915 chenodeoxycholic acid decreases expression EXP   6480464 Chenodeoxycholic Acid results in decreased expression of EDN1 mRNA CTD PMID:16357303 cis-caffeic acid multiple interactions ISO   6480464 [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA CTD PMID:16806235 cisplatin increases expression ISO RGD:730848 6480464 Cisplatin results in increased expression of EDN1 mRNA CTD PMID:21674241 cisplatin decreases response to substance ISO RGD:730848 6480464 EDN1 results in decreased susceptibility to Cisplatin CTD PMID:21656314 cisplatin decreases expression EXP   6480464 Cisplatin results in decreased expression of EDN1 mRNA CTD PMID:22023808 cisplatin multiple interactions ISO RGD:730848 6480464 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 results in decreased susceptibility to Cisplatin] CTD PMID:21656314 clofibrate multiple interactions EXP   6480464 Clofibrate inhibits the reaction [Desoxycorticosterone results in increased expression of EDN1 protein] CTD PMID:16054168 cobalt dichloride increases expression EXP   6480464 cobaltous chloride results in increased expression of EDN1 mRNA CTD PMID:11078377 cobalt dichloride increases expression EXP   6480464 cobaltous chloride results in increased expression of EDN1 mRNA CTD PMID:11078357 PMID:11078377 cobalt dichloride increases expression EXP   6480464 cobaltous chloride results in increased expression of EDN1 mRNA CTD PMID:11078377 PMID:11078357 cobalt dichloride increases expression ISO RGD:730848 6480464 cobaltous chloride results in increased expression of EDN1 mRNA CTD PMID:10939628 cobalt dichloride multiple interactions ISO RGD:730848 6480464 cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]; more ... CTD PMID:10939628 cobalt dichloride decreases expression ISO RGD:730848 6480464 cobaltous chloride results in decreased expression of EDN1 mRNA CTD PMID:19320972 cobalt dichloride decreases expression EXP   6480464 cobaltous chloride results in decreased expression of EDN1 mRNA CTD PMID:15948191 cocaine increases expression EXP   6480464 Cocaine results in increased expression of EDN1 protein CTD PMID:17420087 cocaine increases expression ISO RGD:730848 6480464 Cocaine results in increased expression of EDN1 protein CTD PMID:11948058 more ... cocaine increases expression ISO RGD:730848 6480464 Cocaine results in increased expression of EDN1 protein CTD PMID:9714087 more ... copper atom multiple interactions EXP   6480464 Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein] CTD PMID:20302851 copper(0) multiple interactions EXP   6480464 Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein] CTD PMID:20302851 copper(2+) sulfate increases expression ISO RGD:730848 6480464 Copper Sulfate results in increased expression of EDN1 mRNA CTD PMID:19549813 corticosterone increases secretion EXP   6480464 EDN1 results in increased secretion of Corticosterone CTD PMID:1659878 coumestrol decreases expression ISO RGD:730848 6480464 Coumestrol results in decreased expression of EDN1 mRNA CTD PMID:19167446 coumestrol multiple interactions ISO RGD:730848 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of EDN1 mRNA CTD PMID:19167446 cyclophosphamide increases expression ISO RGD:730848 6480464 Cyclophosphamide results in increased expression of EDN1 protein CTD PMID:18548196 PMID:17562616 cyclophosphamide increases expression ISO RGD:730848 6480464 Cyclophosphamide results in increased expression of EDN1 protein CTD PMID:17562616 PMID:18548196 cyclosporin A multiple interactions EXP   6480464 Cyclosporine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter] CTD PMID:11435416 D-glucose increases expression ISO RGD:730848 6480464 Glucose results in increased expression of EDN1 mRNA CTD PMID:20960276 D-glucose increases expression ISO RGD:730848 6480464 Glucose results in increased expression of EDN1 protein CTD PMID:16428915 D-glucose increases expression ISO RGD:730848 6480464 Glucose results in increased expression of EDN1 mRNA CTD PMID:16428915 PMID:20960276 D-glucose multiple interactions ISO RGD:730848 6480464 carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]; more ... CTD PMID:16428915 D-glucose multiple interactions EXP   6480464 Glucose affects the reaction [EDN1 protein affects the abundance of and affects the localization of Calcium] CTD PMID:12821678 D-glucose multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA] CTD PMID:20960276 dantrolene decreases activity EXP   6480464 Dantrolene results in decreased activity of EDN1 protein CTD PMID:12628492 dapsone multiple interactions ISO   6480464 Dapsone inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA] CTD PMID:21765237 daunorubicin increases expression EXP   6480464 Daunorubicin results in increased expression of EDN1 protein CTD PMID:20888384 daunorubicin multiple interactions EXP   6480464 telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein] CTD PMID:20888384 desferrioxamine B increases expression EXP   6480464 Deferoxamine results in increased expression of EDN1 protein CTD PMID:9357851 dexamethasone multiple interactions ISO   6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of EDN1 mRNA CTD PMID:16054899 dexamethasone multiple interactions ISO   6480464 Dexamethasone inhibits the reaction [nitrofen results in decreased expression of EDN1 mRNA]; more ... CTD PMID:12407540 dexamethasone decreases expression ISO RGD:730848 6480464 Dexamethasone results in decreased expression of EDN1 mRNA CTD PMID:12206003 diazoxide increases expression EXP   6480464 Isoproterenol results in increased expression of EDN1 protein CTD PMID:9861301 diazoxide increases activity EXP   6480464 Isoproterenol results in increased activity of EDN1 promoter CTD PMID:11435416 diazoxide multiple interactions EXP   6480464 Cyclosporine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]; more ... CTD PMID:11435416 dibutyl phthalate increases expression EXP   6480464 Dibutyl Phthalate results in increased expression of EDN1 mRNA CTD PMID:21266533 dibutyl phthalate increases expression ISO   6480464 Dibutyl Phthalate results in increased expression of EDN1 mRNA CTD PMID:17361019 PMID:21266533 dibutyl phthalate increases expression ISO   6480464 Dibutyl Phthalate results in increased expression of EDN1 mRNA CTD PMID:21266533 diclofenac multiple interactions ISO   6480464 Diclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium] CTD PMID:15083534 dioxygen increases expression ISO RGD:730848 6480464 Oxygen deficiency results in increased expression of EDN1 mRNA CTD PMID:17968679 dioxygen increases expression ISO RGD:730848 6480464 Oxygen deficiency results in increased expression of EDN1 protein CTD PMID:18001528 PMID:22363556 dioxygen multiple interactions ISO RGD:730848 6480464 Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein] CTD PMID:22363556 dioxygen increases expression ISO   6480464 Oxygen deficiency results in increased expression of EDN1 mRNA CTD PMID:10939628 PMID:21926265 dioxygen increases expression ISO RGD:730848 6480464 Oxygen deficiency results in increased expression of EDN1 mRNA CTD PMID:10939628 more ... dioxygen increases expression ISO   6480464 Oxygen deficiency results in increased expression of EDN1 mRNA CTD PMID:21926265 PMID:10939628 dioxygen multiple interactions ISO RGD:730848 6480464 Genistein affects the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]; more ... CTD PMID:10939628 dioxygen increases expression ISO RGD:730848 6480464 Oxygen deficiency results in increased expression of EDN1 mRNA CTD PMID:14508066 more ... dioxygen multiple interactions ISO   6480464 rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]; more ... CTD PMID:21926265 dioxygen increases expression ISO   6480464 Oxygen deficiency results in increased expression of EDN1 mRNA; more ... CTD PMID:21926265 dioxygen increases secretion ISO RGD:730848 6480464 Oxygen deficiency results in increased secretion of EDN1 protein CTD PMID:21926265 dioxygen multiple interactions ISO RGD:730848 6480464 caffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein]; more ... CTD PMID:21926265 dioxygen multiple interactions EXP   6480464 MMP2 protein affects the susceptibility to [EDN1 protein co-treated with Oxygen deficiency] CTD PMID:16980344 dioxygen multiple interactions ISO   6480464 MMP2 protein affects the susceptibility to [EDN1 protein co-treated with Oxygen deficiency] CTD PMID:16980344 dioxygen increases expression ISO RGD:730848 6480464 Oxygen deficiency results in increased expression of EDN1 protein CTD PMID:18001528 diprotium oxide affects export ISO   6480464 EDN1 protein affects the export of Water CTD PMID:16340664 doxorubicin increases activity ISO RGD:730848 6480464 Doxorubicin results in increased activity of EDN1 protein CTD PMID:7665224 doxorubicin multiple interactions EXP   6480464 EDN1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:14736733 doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of EDN1 mRNA CTD PMID:17974986 PMID:16766856 doxorubicin multiple interactions EXP   6480464 tyrphostin AG 1478 inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]; more ... CTD PMID:17974986 doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of EDN1 mRNA CTD PMID:16766856 PMID:17974986 doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of EDN1 protein CTD PMID:11589785 doxorubicin multiple interactions ISO   6480464 TLR4 protein affects the reaction [Doxorubicin results in increased expression of EDN1 mRNA]; more ... CTD PMID:18321777 doxorubicin multiple interactions ISO   6480464 PD 98059 inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]; more ... CTD PMID:17974986 doxorubicin increases expression ISO   6480464 Doxorubicin results in increased expression of EDN1 mRNA; more ... CTD PMID:17974986 PMID:18321777 doxorubicin increases expression ISO   6480464 Doxorubicin results in increased expression of EDN1 protein; more ... CTD PMID:18321777 PMID:17974986 doxorubicin multiple interactions ISO RGD:730848 6480464 PD 98059 inhibits the reaction [Doxorubicin results in increased expression of EDN1 mRNA]; more ... CTD PMID:17974986 doxorubicin increases expression ISO RGD:730848 6480464 Doxorubicin results in increased expression of EDN1 protein CTD PMID:17974986 PMID:7969316 dydrogesterone multiple interactions ISO RGD:730848 6480464 Dydrogesterone affects the reaction [Estradiol results in decreased expression of EDN1 protein] CTD PMID:12385860 elemental carbon decreases activity EXP   6480464 Carbon analog results in decreased activity of EDN1 protein CTD PMID:20214918 enalapril multiple interactions EXP   6480464 Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:9175058 enalaprilat dihydrate decreases secretion ISO RGD:730848 6480464 Enalaprilat results in decreased secretion of EDN1 protein CTD PMID:19079593 ethanol multiple interactions EXP   6480464 cyclo(Trp-Asp-Pro-Val-Leu) affects the reaction [Ethanol affects the activity of EDN1 protein] CTD PMID:16651399 ethanol affects activity EXP   6480464 Ethanol affects the activity of EDN1 protein CTD PMID:16651399 ethanol increases expression ISO   6480464 Ethanol results in increased expression of EDN1 mRNA CTD PMID:12193144 formaldehyde increases expression ISO RGD:730848 6480464 Formaldehyde results in increased expression of EDN1 mRNA CTD PMID:17938736 fructose increases expression EXP   6480464 Fructose results in increased expression of EDN1 mRNA CTD PMID:14568997 more ... fructose increases expression EXP   6480464 Fructose results in increased expression of EDN1 mRNA CTD PMID:9869011 more ... fructose increases expression EXP   6480464 Fructose results in increased expression of EDN1 mRNA CTD PMID:9869011 more ... fructose increases expression EXP   6480464 Fructose results in increased expression of EDN1 mRNA CTD PMID:11172478 more ... fructose multiple interactions EXP   6480464 KLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA] CTD PMID:14568997 fructose increases response to substance EXP   6480464 Fructose results in increased susceptibility to EDN1 protein CTD PMID:9869011 fulvestrant multiple interactions ISO RGD:730848 6480464 [fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDN1 mRNA CTD PMID:19943105 genistein multiple interactions ISO RGD:730848 6480464 Genistein inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]; more ... CTD PMID:10939628 glucose increases expression ISO RGD:730848 6480464 Glucose results in increased expression of EDN1 mRNA CTD PMID:20960276 glucose increases expression ISO RGD:730848 6480464 Glucose results in increased expression of EDN1 protein CTD PMID:16428915 glucose increases expression ISO RGD:730848 6480464 Glucose results in increased expression of EDN1 mRNA CTD PMID:16428915 PMID:20960276 glucose multiple interactions ISO RGD:730848 6480464 carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]; more ... CTD PMID:16428915 glucose multiple interactions EXP   6480464 Glucose affects the reaction [EDN1 protein affects the abundance of and affects the localization of Calcium] CTD PMID:12821678 glucose multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA] CTD PMID:20960276 heparin multiple interactions ISO RGD:730848 6480464 Heparin inhibits the reaction [F2 protein results in increased expression of EDN1 mRNA] CTD PMID:8408661 heparin decreases secretion ISO RGD:730848 6480464 Heparin results in decreased secretion of EDN1 protein CTD PMID:8408661 PMID:7509996 heparin decreases expression ISO RGD:730848 6480464 Heparin results in decreased expression of EDN1 mRNA CTD PMID:7509996 PMID:8408661 heparin multiple interactions ISO RGD:730848 6480464 Heparin inhibits the reaction [F2 protein results in increased secretion of EDN1 protein] CTD PMID:8408661 PMID:7509996 heparin multiple interactions EXP   6480464 Heparin inhibits the reaction [EDN1 protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; more ... CTD PMID:1443220 heparin decreases secretion ISO RGD:730848 6480464 Heparin results in decreased secretion of EDN1 protein CTD PMID:7509996 PMID:8408661 heparin multiple interactions ISO RGD:730848 6480464 Heparin inhibits the reaction [F2 protein results in increased secretion of EDN1 protein] CTD PMID:7509996 PMID:8408661 heparin decreases expression ISO RGD:730848 6480464 Heparin results in decreased expression of EDN1 mRNA CTD PMID:8408661 PMID:7509996 histamine multiple interactions ISO RGD:730848 6480464 EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] CTD PMID:12906840 hydralazine multiple interactions EXP   6480464 Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA] CTD PMID:16326922 hydrogen chloride increases expression EXP   6480464 Hydrochloric Acid results in increased expression of EDN1 protein CTD PMID:19262391 hydrogen peroxide affects expression ISO RGD:730848 6480464 Hydrogen Peroxide affects the expression of EDN1 mRNA CTD PMID:20044591 hydrogen peroxide increases secretion ISO RGD:730848 6480464 Hydrogen Peroxide results in increased secretion of EDN1 protein CTD PMID:14623829 PMID:20021702 hydrogen peroxide multiple interactions ISO RGD:730848 6480464 epigallocatechin gallate inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]; more ... CTD PMID:20021702 hydrogen peroxide multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein] CTD PMID:14623829 PMID:20021702 hydrogen peroxide multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA] CTD PMID:11755377 more ... hydrogen peroxide multiple interactions ISO RGD:730848 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]; more ... CTD PMID:14623829 hydrogen peroxide multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA] CTD PMID:11755377 more ... hydrogen peroxide increases secretion ISO RGD:730848 6480464 Hydrogen Peroxide results in increased secretion of EDN1 protein CTD PMID:14623829 hydrogen peroxide increases expression ISO RGD:730848 6480464 Hydrogen Peroxide results in increased expression of EDN1 mRNA CTD PMID:11755377 more ... hydrogen peroxide increases expression ISO RGD:730848 6480464 Hydrogen Peroxide results in increased expression of EDN1 mRNA CTD PMID:11755377 more ... hydrogen peroxide increases expression ISO RGD:730848 6480464 Hydrogen Peroxide results in increased expression of EDN1 mRNA CTD PMID:18234130 more ... hydrogen peroxide increases expression ISO RGD:730848 6480464 Hydrogen Peroxide results in increased expression of EDN1 mRNA CTD PMID:18234130 more ... hydrogen peroxide increases expression ISO RGD:730848 6480464 Hydrogen Peroxide results in increased expression of EDN1 mRNA CTD PMID:11755377 more ... hydrogen peroxide multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA] CTD PMID:18234130 PMID:11755377 hydrogen peroxide increases expression ISO RGD:730848 6480464 Hydrogen Peroxide results in increased expression of EDN1 mRNA CTD PMID:11755377 more ... hydrogen peroxide decreases expression EXP   6480464 Hydrogen Peroxide results in decreased expression of EDN1 protein CTD PMID:9357851 hydrogen peroxide multiple interactions EXP   6480464 CAT protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of EDN1 protein] CTD PMID:9357851 hydrogen peroxide multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA] CTD PMID:11755377 PMID:18234130 hydrogen peroxide multiple interactions ISO RGD:730848 6480464 Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein]; more ... CTD PMID:11755377 hydrogen peroxide increases expression ISO RGD:730848 6480464 Hydrogen Peroxide results in increased expression of EDN1 mRNA CTD PMID:12414654 more ... hydrogen peroxide increases expression ISO RGD:730848 6480464 Hydrogen Peroxide results in increased expression of EDN1 protein CTD PMID:11755377 indomethacin increases expression ISO RGD:730848 6480464 Indomethacin results in increased expression of EDN1 mRNA CTD PMID:16984733 indomethacin increases expression EXP   6480464 Indomethacin results in increased expression of EDN1 protein CTD PMID:10423059 more ... indomethacin decreases activity ISO RGD:730848 6480464 EDN1 protein results in decreased activity of Indomethacin CTD PMID:12906840 indomethacin multiple interactions ISO RGD:730848 6480464 BQ 788 inhibits the reaction [EDN1 protein results in decreased activity of Indomethacin]; more ... CTD PMID:12906840 indomethacin multiple interactions EXP   6480464 phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein] CTD PMID:16280098 PMID:11145282 indomethacin increases expression EXP   6480464 Indomethacin results in increased expression of EDN1 protein CTD PMID:16280098 more ... indomethacin increases expression EXP   6480464 Indomethacin results in increased expression of EDN1 protein CTD PMID:10423059 more ... indomethacin multiple interactions EXP   6480464 Sucralfate inhibits the reaction [Indomethacin results in increased expression of EDN1 protein] CTD PMID:10423059 indomethacin multiple interactions EXP   6480464 phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein] CTD PMID:11145282 PMID:16280098 indomethacin increases expression EXP   6480464 Indomethacin results in increased expression of EDN1 protein CTD PMID:16280098 more ... indomethacin multiple interactions EXP   6480464 EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]; more ... CTD PMID:16280098 indomethacin decreases secretion ISO RGD:730848 6480464 Indomethacin results in decreased secretion of EDN1 protein CTD PMID:16133044 iodixanol increases expression EXP   6480464 iodixanol results in increased expression of EDN1 protein CTD PMID:21354280 iopromide increases expression EXP   6480464 iopromide results in increased expression of EDN1 protein CTD PMID:21354280 irbesartan affects response to substance ISO RGD:730848 6480464 EDN1 gene polymorphism affects the susceptibility to irbesartan CTD PMID:15188945 iron atom multiple interactions EXP   6480464 Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein] CTD PMID:20302851 isoprenaline multiple interactions EXP   6480464 Cyclosporine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter]; more ... CTD PMID:11435416 isoprenaline increases activity EXP   6480464 Isoproterenol results in increased activity of EDN1 promoter CTD PMID:11435416 isoprenaline increases expression EXP   6480464 Isoproterenol results in increased expression of EDN1 protein CTD PMID:9861301 isosorbide dinitrate multiple interactions ISO RGD:730848 6480464 [Isosorbide Dinitrate co-treated with Plant Preparations] results in decreased expression of EDN1 mRNA CTD PMID:15719745 L-ascorbic acid multiple interactions ISO RGD:730848 6480464 [Tretinoin co-treated with Ascorbic Acid] results in increased expression of EDN1 mRNA CTD PMID:16443354 leflunomide increases expression ISO   6480464 leflunomide results in increased expression of EDN1 mRNA CTD PMID:19751817 leukotriene C4 increases expression ISO RGD:730848 6480464 Leukotriene C4 results in increased expression of EDN1 mRNA; more ... CTD PMID:11372388 leukotriene C4 multiple interactions ISO RGD:730848 6480464 zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 mRNA]; more ... CTD PMID:11372388 lignoceric acid increases expression ISO RGD:730848 6480464 lignoceric acid results in increased expression of EDN1 protein CTD PMID:16895544 linalool increases expression ISO RGD:730848 6480464 linalool results in increased expression of EDN1 mRNA CTD PMID:19922762 lisinopril dihydrate decreases secretion ISO RGD:730848 6480464 Lisinopril results in decreased secretion of EDN1 protein CTD PMID:19079593 losartan decreases expression ISO RGD:730848 6480464 Losartan results in decreased expression of EDN1 protein CTD PMID:11369837 losartan decreases expression EXP   6480464 Losartan results in decreased expression of EDN1 mRNA CTD PMID:16191423 PMID:18971572 losartan decreases expression EXP   6480464 Losartan results in decreased expression of EDN1 protein CTD PMID:16191423 losartan decreases expression EXP   6480464 Losartan results in decreased expression of EDN1 mRNA CTD PMID:18971572 losartan multiple interactions EXP   6480464 Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein] CTD PMID:12901495 losartan multiple interactions ISO RGD:730848 6480464 Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein] CTD PMID:17666345 LY294002 multiple interactions EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein] CTD PMID:12411397 melphalan increases expression ISO RGD:730848 6480464 Melphalan results in increased expression of EDN1 protein CTD PMID:18548196 menadione affects expression ISO RGD:730848 6480464 Vitamin K 3 affects the expression of EDN1 mRNA CTD PMID:20044591 menadione increases expression ISO RGD:730848 6480464 Vitamin K 3 results in increased expression of EDN1 mRNA CTD PMID:12414654 metoprolol multiple interactions EXP   6480464 Metoprolol inhibits the reaction [Norepinephrine results in increased expression of EDN1 mRNA] CTD PMID:11435416 mevalonic acid multiple interactions ISO RGD:730848 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 protein]; more ... CTD PMID:18390205 mono(2-ethylhexyl) phthalate increases expression EXP   6480464 mono-(2-ethylhexyl)phthalate results in increased expression of EDN1 mRNA CTD PMID:16809437 monocrotaline multiple interactions EXP   6480464 4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]; more ... CTD PMID:16225752 monocrotaline increases expression EXP   6480464 Monocrotaline results in increased expression of EDN1 protein CTD PMID:20967148 PMID:16225752 monocrotaline increases expression EXP   6480464 Monocrotaline results in increased expression of EDN1 mRNA CTD PMID:16225752 PMID:22022327 monocrotaline multiple interactions EXP   6480464 Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA] CTD PMID:22022327 monocrotaline increases expression EXP   6480464 Monocrotaline results in increased expression of EDN1 mRNA CTD PMID:22022327 PMID:16225752 monocrotaline increases expression EXP   6480464 Monocrotaline results in increased expression of EDN1 protein CTD PMID:16225752 PMID:20967148 monocrotaline multiple interactions EXP   6480464 bosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA] CTD PMID:20967148 monocrotaline increases expression EXP   6480464 Monocrotaline results in increased expression of EDN1 mRNA CTD PMID:16225752 N-acetyl-L-cysteine multiple interactions EXP   6480464 Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]; more ... CTD PMID:16261333 N-acetyl-L-cysteine multiple interactions ISO   6480464 Acetylcysteine inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA] CTD PMID:21765237 N-acetyl-L-cysteine multiple interactions ISO RGD:730848 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]; more ... CTD PMID:14623829 N-nitrosodiethylamine multiple interactions EXP   6480464 Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of EDN1 protein] CTD PMID:20302851 naphthalene increases expression ISO   6480464 naphthalene results in increased expression of EDN1 mRNA CTD PMID:18978301 nifedipine decreases activity EXP   6480464 Nifedipine results in decreased activity of EDN1 protein CTD PMID:12628492 nifedipine increases activity EXP   6480464 Nifedipine results in increased activity of EDN1 protein CTD PMID:7528292 nifedipine multiple interactions EXP   6480464 Nifedipine inhibits the reaction [Isoproterenol results in increased activity of EDN1 promoter] CTD PMID:11435416 nimesulide multiple interactions EXP   6480464 nimesulide inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]; more ... CTD PMID:21811393 nitric oxide increases chemical synthesis ISO RGD:730848 6480464 EDN1 protein results in increased chemical synthesis of Nitric Oxide CTD PMID:11187978 nitric oxide increases expression ISO   6480464 Nitric Oxide results in increased expression of EDN1 mRNA CTD PMID:20197249 nitric oxide increases secretion EXP   6480464 Nitric Oxide results in increased secretion of EDN1 protein CTD PMID:15640287 nitric oxide increases expression EXP   6480464 Nitric Oxide deficiency results in increased expression of EDN1 mRNA CTD PMID:16326922 nitric oxide decreases activity EXP   6480464 Nitric Oxide deficiency results in decreased activity of EDN1 protein CTD PMID:16810074 nitric oxide multiple interactions EXP   6480464 Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:16389725 nitric oxide multiple interactions EXP   6480464 Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]; more ... CTD PMID:16326922 nitric oxide increases abundance EXP   6480464 EDN1 protein results in increased abundance of Nitric Oxide CTD PMID:16380457 nitric oxide multiple interactions EXP   6480464 BQ 788 inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]; more ... CTD PMID:16380457 nitric oxide increases expression ISO RGD:730848 6480464 Nitric Oxide results in increased expression of EDN1 protein CTD PMID:20929026 nitric oxide decreases expression ISO RGD:730848 6480464 Nitric Oxide results in decreased expression of EDN1 protein CTD PMID:15838368 nitroglycerin decreases expression ISO RGD:730848 6480464 Nitroglycerin results in decreased expression of EDN1 mRNA CTD PMID:12206003 nitroglycerin increases expression EXP   6480464 Nitroglycerin results in increased expression of EDN1 protein CTD PMID:12901495 nitroglycerin decreases expression EXP   6480464 Nitroglycerin results in decreased expression of EDN1 protein; more ... CTD PMID:11751199 nitroglycerin multiple interactions EXP   6480464 Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein] CTD PMID:12901495 nitroprusside multiple interactions EXP   6480464 Nitroprusside inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased activity of TH protein] CTD PMID:16023617 nitroprusside multiple interactions EXP   6480464 Nitroprusside inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:16389725 oleic acid decreases expression ISO RGD:730848 6480464 Oleic Acid results in decreased expression of EDN1 mRNA; more ... CTD PMID:16895544 olmesartan decreases expression EXP   6480464 olmesartan medoxomil results in decreased expression of EDN1 mRNA CTD PMID:16336959 ouabain increases expression EXP   6480464 Ouabain results in increased expression of EDN1 mRNA CTD PMID:15477225 ozone increases expression EXP   6480464 Ozone results in increased expression of EDN1 mRNA CTD PMID:16716893 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of EDN1 mRNA CTD PMID:16081523 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of EDN1 mRNA CTD PMID:20980218 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of EDN1 mRNA CTD PMID:16716893 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of EDN1 mRNA CTD PMID:16716893 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of EDN1 mRNA CTD PMID:16081523 more ... ozone increases expression EXP   6480464 Ozone results in increased expression of EDN1 protein CTD PMID:16081523 PMID:16741034 ozone increases expression EXP   6480464 Ozone results in increased expression of EDN1 mRNA CTD PMID:16716893 more ... ozone multiple interactions EXP   6480464 [Particulate Matter co-treated with Ozone] results in increased expression of EDN1 mRNA CTD PMID:16081523 ozone increases expression EXP   6480464 Ozone results in increased expression of EDN1 protein CTD PMID:16741034 PMID:16081523 palmitic acid increases expression ISO RGD:730848 6480464 Palmitic Acid results in increased expression of EDN1 protein; more ... CTD PMID:16895544 paracetamol multiple interactions EXP   6480464 Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]; more ... CTD PMID:21811393 paracetamol affects expression ISO   6480464 Acetaminophen affects the expression of EDN1 mRNA CTD PMID:17562736 paraquat multiple interactions ISO   6480464 Acetylcysteine inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]; more ... CTD PMID:21765237 paraquat increases expression EXP   6480464 Paraquat results in increased expression of EDN1 mRNA; more ... CTD PMID:17235729 paraquat multiple interactions EXP   6480464 green tea extract AR25 inhibits the reaction [Paraquat results in increased expression of EDN1 mRNA]; more ... CTD PMID:17235729 paraquat increases expression ISO   6480464 Paraquat results in increased expression of EDN1 mRNA CTD PMID:21765237 paricalcitol multiple interactions EXP   6480464 paricalcitol inhibits the reaction [EDN1 protein results in increased expression of NPPA mRNA]; more ... CTD PMID:21565836 PD123319 multiple interactions EXP   6480464 PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein] CTD PMID:15007106 phenobarbital decreases expression ISO RGD:730848 6480464 Phenobarbital results in decreased expression of EDN1 mRNA CTD PMID:19084549 phenylephrine increases response to substance EXP   6480464 EDN1 protein results in increased susceptibility to Phenylephrine CTD PMID:20977430 phenylephrine multiple interactions EXP   6480464 ZFPM2 protein inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA] CTD PMID:15220332 phenylephrine multiple interactions EXP   6480464 Y 27632 inhibits the reaction [Phenylephrine results in increased expression of EDN1 mRNA] CTD PMID:11739382 phenylephrine multiple interactions EXP   6480464 Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein] CTD PMID:15007106 phenylephrine increases expression EXP   6480464 Phenylephrine results in increased expression of EDN1 protein CTD PMID:15220332 phenylephrine increases expression EXP   6480464 Phenylephrine results in increased expression of EDN1 mRNA CTD PMID:10788492 phenylephrine multiple interactions EXP   6480464 Phenylephrine promotes the reaction [GATA4 protein binds to EDN1 promoter] CTD PMID:10788492 phenylephrine multiple interactions ISO RGD:730848 6480464 EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA] CTD PMID:12724418 phenylephrine multiple interactions EXP   6480464 Polyphenols inhibits the reaction [EDN1 protein results in increased susceptibility to Phenylephrine] CTD PMID:20977430 phosgene increases expression EXP   6480464 Phosgene results in increased expression of EDN1 protein CTD PMID:18645720 potassium atom multiple interactions ISO   6480464 Diclofenac inhibits the reaction [EDN1 protein results in decreased transport of Potassium] CTD PMID:15083534 potassium atom decreases transport ISO   6480464 EDN1 protein results in decreased transport of Potassium CTD PMID:15083534 potassium chloride multiple interactions EXP   6480464 [19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased expression of EDN1 mRNA CTD PMID:18823320 potassium chloride multiple interactions EXP   6480464 Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased expression of TAC1 mRNA]; more ... CTD PMID:21811393 pravastatin decreases expression ISO RGD:730848 6480464 Pravastatin results in decreased expression of EDN1 protein CTD PMID:12105140 pravastatin decreases expression EXP   6480464 Pravastatin results in decreased expression of EDN1 protein; more ... CTD PMID:19812503 prazosin multiple interactions EXP   6480464 Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein] CTD PMID:15007106 prazosin multiple interactions EXP   6480464 Prazosin inhibits the reaction [EDN1 protein results in increased expression of NPPA protein] CTD PMID:12513686 propofol decreases chemical synthesis ISO RGD:730848 6480464 Propofol results in decreased chemical synthesis of EDN1 protein CTD PMID:9138053 propofol multiple interactions ISO RGD:730848 6480464 Propofol inhibits the reaction [EDN1 protein affects the transport of Calcium] CTD PMID:9138053 propofol decreases expression EXP   6480464 Propofol results in decreased expression of EDN1 protein CTD PMID:17470888 prostaglandin E2 increases secretion ISO   6480464 EDN1 protein results in increased secretion of Dinoprostone CTD PMID:16384872 prostaglandin E2 multiple interactions EXP   6480464 Acetaminophen inhibits the reaction [[KNG1 protein co-treated with F2 protein co-treated with EDN1 protein co-treated with Potassium Chloride] results in increased secretion of Dinoprostone]; more ... CTD PMID:21811393 quercetin multiple interactions ISO RGD:730848 6480464 Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein] CTD PMID:11755377 quercetin decreases expression ISO RGD:730848 6480464 Quercetin results in decreased expression of EDN1 mRNA CTD PMID:18234130 PMID:20021702 quercetin decreases secretion ISO RGD:730848 6480464 Quercetin results in decreased secretion of EDN1 protein CTD PMID:20021702 quercetin multiple interactions ISO RGD:730848 6480464 Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA]; more ... CTD PMID:20021702 quercetin increases expression ISO RGD:730848 6480464 Quercetin results in increased expression of EDN1 mRNA CTD PMID:21632981 quercetin decreases expression ISO RGD:730848 6480464 Quercetin results in decreased expression of EDN1 mRNA CTD PMID:18234130 quinapril hydrochloride decreases expression ISO RGD:730848 6480464 quinapril results in decreased expression of EDN1 CTD PMID:12149661 quinapril hydrochloride decreases expression ISO RGD:730848 6480464 quinapril results in decreased expression of EDN1 protein CTD PMID:12425201 resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA] CTD PMID:11755377 PMID:18234130 resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA] CTD PMID:11755377 more ... resveratrol multiple interactions ISO   6480464 [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA CTD PMID:16806235 resveratrol decreases expression ISO RGD:730848 6480464 resveratrol results in decreased expression of EDN1 mRNA CTD PMID:14623829 more ... resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein] CTD PMID:14623829 PMID:20021702 resveratrol decreases secretion ISO RGD:730848 6480464 resveratrol results in decreased secretion of EDN1 protein CTD PMID:14623829 PMID:20021702 resveratrol multiple interactions ISO RGD:730848 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of EDN1 mRNA CTD PMID:19167446 resveratrol decreases expression ISO RGD:730848 6480464 resveratrol results in decreased expression of EDN1 mRNA CTD PMID:14623829 more ... resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA] CTD PMID:11755377 more ... resveratrol decreases secretion ISO RGD:730848 6480464 resveratrol results in decreased secretion of EDN1 protein CTD PMID:14623829 resveratrol decreases expression ISO   6480464 resveratrol results in decreased expression of EDN1 mRNA CTD PMID:22935447 resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein] CTD PMID:14623829 resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA] CTD PMID:18234130 PMID:11755377 resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of EDN1 CTD PMID:16535856 resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA] CTD PMID:15878161 resveratrol decreases expression ISO RGD:730848 6480464 resveratrol results in decreased expression of EDN1 mRNA CTD PMID:18234130 resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA] CTD PMID:20960276 resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein] CTD PMID:11755377 rifampicin multiple interactions ISO RGD:730848 6480464 [Rifampin co-treated with NR1I2 protein] results in increased expression of EDN1 mRNA CTD PMID:21127053 Ro 31-8220 multiple interactions EXP   6480464 Ro 31-8220 inhibits the reaction [EDN1 protein results in increased phosphorylation of JUN protein] CTD PMID:12169099 rolipram increases activity EXP   6480464 Rolipram results in increased activity of EDN1 protein CTD PMID:15464066 rosiglitazone multiple interactions ISO   6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of EDN1 mRNA CTD PMID:16054899 rosiglitazone multiple interactions ISO   6480464 rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]; more ... CTD PMID:21926265 rotenone multiple interactions EXP   6480464 Rotenone results in increased expression of and results in increased secretion of EDN1 protein CTD PMID:11707688 rotenone increases expression EXP   6480464 Rotenone results in increased expression of EDN1 mRNA CTD PMID:11707688 PMID:11078378 rotenone increases expression EXP   6480464 Rotenone results in increased expression of EDN1 mRNA CTD PMID:11078378 PMID:11707688 sevoflurane affects expression EXP   6480464 sevoflurane affects the expression of EDN1 mRNA CTD PMID:15967596 sildenafil multiple interactions ISO RGD:730848 6480464 sildenafil inhibits the reaction [EDN1 protein results in increased expression of TRPC1 mRNA] CTD PMID:18818482 silicon dioxide increases expression ISO   6480464 Silicon Dioxide results in increased expression of EDN1 mRNA CTD PMID:19073995 simvastatin decreases secretion ISO RGD:730848 6480464 Simvastatin results in decreased secretion of EDN1 protein CTD PMID:16375908 simvastatin decreases expression EXP   6480464 Simvastatin results in decreased expression of EDN1 mRNA CTD PMID:19099753 PMID:21844074 simvastatin decreases expression EXP   6480464 Simvastatin results in decreased expression of EDN1 mRNA CTD PMID:21844074 PMID:19099753 simvastatin multiple interactions ISO RGD:730848 6480464 Simvastatin results in increased expression of and results in increased secretion of EDN1 protein CTD PMID:20369390 simvastatin multiple interactions EXP   6480464 Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA] CTD PMID:22022327 simvastatin multiple interactions ISO RGD:730848 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA]; more ... CTD PMID:18390205 simvastatin decreases expression ISO RGD:730848 6480464 Simvastatin results in decreased expression of EDN1 mRNA; more ... CTD PMID:18390205 simvastatin multiple interactions EXP   6480464 Simvastatin inhibits the reaction [EDN1 protein results in increased expression of CLCN3 protein] CTD PMID:20644009 sirolimus multiple interactions EXP   6480464 Sirolimus inhibits the reaction [EDN1 protein results in increased phosphorylation of EIF4EBP1 protein]; more ... CTD PMID:12411397 sodium atom affects response to substance ISO   6480464 EDN1 protein affects the susceptibility to Sodium CTD PMID:16340664 sodium atom affects export ISO   6480464 EDN1 protein affects the export of Sodium CTD PMID:16340664 sodium chloride multiple interactions EXP   6480464 [19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] results in increased expression of EDN1 mRNA CTD PMID:18823320 staurosporine decreases activity EXP   6480464 Staurosporine results in decreased activity of EDN1 protein CTD PMID:15464066 stearic acid increases expression ISO RGD:730848 6480464 stearic acid results in increased expression of EDN1 protein; more ... CTD PMID:16895544 stilbene-4,4'-diol decreases secretion ISO RGD:730848 6480464 4,4'-dihydroxystilbene results in decreased secretion of EDN1 protein CTD PMID:21554123 stilbene-4,4'-diol decreases expression ISO RGD:730848 6480464 4,4'-dihydroxystilbene results in decreased expression of EDN1 mRNA CTD PMID:21554123 streptozocin increases expression EXP   6480464 Streptozocin results in increased expression of EDN1 mRNA CTD PMID:12967931 streptozocin increases expression EXP   6480464 Streptozocin results in increased expression of EDN1 mRNA CTD PMID:12458661 PMID:12967931 streptozocin multiple interactions EXP   6480464 Bezafibrate inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA] CTD PMID:12967931 sulfur dioxide increases expression EXP   6480464 Sulfur Dioxide results in increased expression of EDN1 protein; more ... CTD PMID:20083630 superoxide multiple interactions EXP   6480464 Catechin inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]; more ... CTD PMID:20977430 superoxide increases abundance EXP   6480464 EDN1 protein results in increased abundance of Superoxides CTD PMID:20977430 tacrolimus hydrate increases expression EXP   6480464 Tacrolimus results in increased expression of EDN1 protein CTD PMID:9931093 tacrolimus hydrate increases expression EXP   6480464 Tacrolimus results in increased expression of EDN1 mRNA CTD PMID:9517403 PMID:9931093 tacrolimus hydrate increases expression EXP   6480464 Tacrolimus results in increased expression of EDN1 mRNA CTD PMID:9931093 PMID:9517403 tamibarotene increases expression ISO RGD:730848 6480464 Am 80 results in increased expression of EDN1 mRNA; more ... CTD PMID:15498508 tamoxifen multiple interactions ISO RGD:730848 6480464 Estradiol promotes the reaction [[ZD4054 co-treated with Tamoxifen] results in decreased expression of EDN1 mRNA]; more ... CTD PMID:19943105 tamoxifen affects expression ISO   6480464 Tamoxifen affects the expression of EDN1 mRNA CTD PMID:17555576 tamoxifen increases expression ISO RGD:730848 6480464 Tamoxifen results in increased expression of EDN1 mRNA CTD PMID:19943105 telmisartan multiple interactions EXP   6480464 telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein] CTD PMID:20888384 tert-butyl hydroperoxide increases expression ISO RGD:730848 6480464 tert-Butylhydroperoxide results in increased expression of EDN1 mRNA CTD PMID:12414654 testosterone multiple interactions ISO RGD:730848 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of EDN1 mRNA CTD PMID:21592394 testosterone increases expression ISO RGD:730848 6480464 Testosterone results in increased expression of EDN1 mRNA CTD PMID:21592394 testosterone affects expression EXP   6480464 Testosterone affects the expression of EDN1 mRNA CTD PMID:12122504 PMID:14616470 tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of EDN1 protein CTD PMID:12575897 more ... tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of EDN1 protein CTD PMID:12708965 more ... tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of EDN1 protein CTD PMID:12632514 more ... tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of EDN1 protein CTD PMID:12708965 more ... tetrachloromethane multiple interactions EXP   6480464 IL10 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of EDN1 protein] CTD PMID:12632514 tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of EDN1 protein CTD PMID:12575897 more ... tetrachloromethane increases expression EXP   6480464 Carbon Tetrachloride results in increased expression of EDN1 mRNA CTD PMID:17595544 tetrachloromethane multiple interactions EXP   6480464 Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]; more ... CTD PMID:18205269 tetrachloromethane increases expression ISO   6480464 Carbon Tetrachloride results in increased expression of EDN1 mRNA CTD PMID:17484886 theophylline multiple interactions ISO RGD:730848 6480464 Theophylline inhibits the reaction [CSF2 protein results in increased expression of EDN1 mRNA] CTD PMID:10374451 thymidine increases uptake ISO RGD:730848 6480464 EDN1 protein results in increased uptake of Thymidine CTD PMID:10100047 trans-resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA] CTD PMID:11755377 PMID:18234130 trans-resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA] CTD PMID:11755377 more ... trans-resveratrol multiple interactions ISO   6480464 [resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of EDN1 mRNA CTD PMID:16806235 trans-resveratrol decreases expression ISO RGD:730848 6480464 resveratrol results in decreased expression of EDN1 mRNA CTD PMID:14623829 more ... trans-resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein] CTD PMID:14623829 PMID:20021702 trans-resveratrol decreases secretion ISO RGD:730848 6480464 resveratrol results in decreased secretion of EDN1 protein CTD PMID:14623829 PMID:20021702 trans-resveratrol multiple interactions ISO RGD:730848 6480464 [Coumestrol co-treated with resveratrol] results in decreased expression of EDN1 mRNA CTD PMID:19167446 trans-resveratrol decreases expression ISO RGD:730848 6480464 resveratrol results in decreased expression of EDN1 mRNA CTD PMID:14623829 more ... trans-resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA] CTD PMID:11755377 more ... trans-resveratrol decreases secretion ISO RGD:730848 6480464 resveratrol results in decreased secretion of EDN1 protein CTD PMID:14623829 trans-resveratrol decreases expression ISO   6480464 resveratrol results in decreased expression of EDN1 mRNA CTD PMID:22935447 trans-resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased secretion of EDN1 protein] CTD PMID:14623829 trans-resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 mRNA] CTD PMID:18234130 PMID:11755377 trans-resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of EDN1 CTD PMID:16535856 trans-resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA] CTD PMID:15878161 trans-resveratrol decreases expression ISO RGD:730848 6480464 resveratrol results in decreased expression of EDN1 mRNA CTD PMID:18234130 trans-resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA] CTD PMID:20960276 trans-resveratrol multiple interactions ISO RGD:730848 6480464 resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of EDN1 protein] CTD PMID:11755377 troglitazone multiple interactions ISO RGD:730848 6480464 troglitazone inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein] CTD PMID:17666345 ursodeoxycholic acid decreases expression ISO RGD:730848 6480464 Ursodeoxycholic Acid results in decreased expression of EDN1 mRNA; more ... CTD PMID:15556138 valproic acid affects expression ISO   6480464 Valproic Acid affects the expression of EDN1 mRNA CTD PMID:17292431 valsartan multiple interactions EXP   6480464 [valsartan co-treated with benazepril] results in decreased expression of EDN1 protein CTD PMID:11136700 vanadyl sulfate increases expression ISO RGD:730848 6480464 vanadyl sulfate results in increased expression of EDN1 mRNA CTD PMID:16330358 water affects export ISO   6480464 EDN1 protein affects the export of Water CTD PMID:16340664 wortmannin multiple interactions ISO   6480464 wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]] CTD PMID:12839867 zafirlukast multiple interactions ISO RGD:730848 6480464 zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 mRNA]; more ... CTD PMID:11372388 zafirlukast decreases expression ISO RGD:730848 6480464 zafirlukast results in decreased expression of EDN1 protein CTD PMID:12781059 zinc atom multiple interactions ISO RGD:730848 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of EDN1 mRNA CTD PMID:18593933 zinc(0) multiple interactions ISO RGD:730848 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of EDN1 mRNA CTD PMID:18593933 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) artery smooth muscle contraction   ISO RGD:730848 1624291 PMID:8982507 RGD PMID:8982507 body fluid secretion   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 calcium-mediated signaling   ISO RGD:730848 1624291 PMID:10770212 RGD PMID:10770212 calcium-mediated signaling   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 calcium-mediated signaling   ISO RGD:730848 1624291 PMID:1917960 RGD PMID:1917960 cartilage development   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 cell growth   IDA   4892556   RGD   cell surface receptor signaling pathway   ISO RGD:730848 1624291 PMID:1713452 RGD PMID:1713452 cell-cell signaling   ISO RGD:730848 1624291 PMID:12379507 RGD PMID:12379507 cellular response to interleukin-1   IEP   4144864   RGD   cellular response to tumor necrosis factor   IEP   4144864   RGD   dorsal/ventral pattern formation   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 elevation of cytosolic calcium ion concentration   ISO RGD:730848 1624291 PMID:1917960 RGD PMID:1917960 elevation of cytosolic calcium ion concentration   IDA   4892583   RGD   elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 epithelial fluid transport   IDA   4892575   RGD   G-protein coupled receptor signaling pathway   ISO RGD:730848 1624291 PMID:17078114 RGD PMID:17078114 glucose transport   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 heart development   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 histamine secretion   IDA   4892576   RGD   in utero embryonic development   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 inositol phosphate-mediated signaling   ISO RGD:730848 1624291 PMID:1917960 RGD PMID:1917960 inositol phosphate-mediated signaling   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 intracellular protein kinase cascade   IDA   727457   RGD   maternal process involved in parturition   IEP   4892575   RGD   membrane depolarization   IMP   1580292   RGD   middle ear morphogenesis   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 multicellular organismal aging   IEP   4144863 arteries RGD   negative regulation of cAMP biosynthetic process   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of cellular protein metabolic process   ISO RGD:730848 1624291 PMID:19767294 RGD PMID:19767294 negative regulation of cellular protein metabolic process   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of hormone secretion   IDA   1581817   RGD   negative regulation of nitric-oxide synthase biosynthetic process   ISO RGD:730848 1624291 PMID:16820593 RGD PMID:16820593 negative regulation of nitric-oxide synthase biosynthetic process   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of smooth muscle cell apoptotic process   IDA   4892596   RGD   negative regulation of transcription from RNA polymerase II promoter   ISO RGD:730848 1624291 PMID:19767294 RGD PMID:19767294 negative regulation of transcription from RNA polymerase II promoter   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 neural crest cell development   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 neutrophil chemotaxis NOT ISO RGD:730848 1624291 PMID:9696419 RGD PMID:9696419 nitric oxide transport   ISO RGD:730848 1624291 PMID:16820593 RGD PMID:16820593 nitric oxide transport   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 patterning of blood vessels   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 peptide hormone secretion   ISO RGD:730848 1624291 PMID:10770212 RGD PMID:10770212 peptide hormone secretion   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 phosphatidylinositol 3-kinase cascade   ISO RGD:730848 1624291 PMID:17078114 RGD PMID:17078114 phosphatidylinositol 3-kinase cascade   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 phospholipase D-activating G-protein coupled receptor signaling pathway   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of cardiac muscle hypertrophy   ISO RGD:730848 1624291 PMID:12847114 RGD PMID:12847114 positive regulation of cardiac muscle hypertrophy   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of cell migration   ISO RGD:730848 1624291 PMID:9696419 RGD PMID:9696419 positive regulation of cell proliferation   IDA   4892557   RGD   positive regulation of cell proliferation   ISO RGD:730848 1624291 PMID:1917960 RGD PMID:1917960 positive regulation of cell proliferation   ISO RGD:730848 1624291 PMID:17078114 RGD PMID:17078114 positive regulation of cell proliferation   TAS   727457   RGD   positive regulation of cell size   ISO RGD:730848 1624291 PMID:12847114 RGD PMID:12847114 positive regulation of cell size   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of heart rate   ISO RGD:730848 1624291 PMID:2649896 RGD PMID:2649896 positive regulation of heart rate   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of hormone secretion   ISO RGD:730848 1624291 PMID:10770212 RGD PMID:10770212 positive regulation of hormone secretion   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of JUN kinase activity   ISO RGD:730848 1624291 PMID:12847114 RGD PMID:12847114 positive regulation of JUN kinase activity   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of MAP kinase activity   ISO RGD:730848 1624291 PMID:10770212 RGD PMID:10770212 positive regulation of MAP kinase activity   ISO RGD:730848 1624291 PMID:12847114 RGD PMID:12847114 positive regulation of mitosis   ISO RGD:730848 1624291 PMID:10770212 RGD PMID:10770212 positive regulation of mitosis   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of neutrophil chemotaxis   IDA   4892576   RGD   positive regulation of odontogenesis   IDA   4892598   RGD   positive regulation of prostaglandin-endoperoxide synthase activity   ISO RGD:730848 1624291 PMID:9492062 RGD PMID:9492062 positive regulation of prostaglandin-endoperoxide synthase activity   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of receptor biosynthetic process   ISO RGD:730848 1624291 PMID:17178876 RGD PMID:17178876 positive regulation of receptor biosynthetic process   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of renal sodium excretion   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of sarcomere organization   ISO RGD:730848 1624291 PMID:12847114 RGD PMID:12847114 positive regulation of sarcomere organization   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of smooth muscle cell proliferation   ISO RGD:730848 1624291 PMID:10393673 RGD PMID:10393673 positive regulation of smooth muscle cell proliferation   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of smooth muscle contraction   IDA   1581797   RGD   positive regulation of urine volume   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 prostaglandin biosynthetic process   ISO RGD:730848 1624291 PMID:9492062 RGD PMID:9492062 prostaglandin biosynthetic process   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 protein kinase C deactivation   ISO RGD:730848 1624291 PMID:16820593 RGD PMID:16820593 protein kinase C deactivation   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 protein kinase C-activating G-protein coupled receptor signaling pathway   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of blood pressure   IMP   1580293   RGD   regulation of pH   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of sensory perception of pain   IDA   4892558   RGD   regulation of systemic arterial blood pressure by endothelin   ISO RGD:730848 1624291 PMID:2649896 RGD PMID:2649896 regulation of systemic arterial blood pressure by endothelin   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of vasoconstriction   IEA InterPro:IPR001928|InterPro:IPR019764 1600115 GO_REF:0000002 InterPro GO_REF:0000002 respiratory gaseous exchange   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to amino acid stimulus   IEP   4144131 methionine-rich diet RGD   response to drug   IEP   4144133 bosentan RGD   response to drug   IEP   4144838 losartan, aliskiren RGD   response to hypoxia   IEP   625753   RGD   response to lipopolysaccharide   IEP   4144129   RGD   response to nicotine   IEP   4144132   RGD   response to testosterone stimulus   IEP   4144839 5alpha-dihydrotestosterone RGD   rhythmic excitation   IEA Ensembl:ENSMUSP00000021796 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 sensory perception of pain   IDA   4892559   RGD   superoxide anion generation   IDA   4892602   RGD   vasoconstriction   ISO RGD:730848 1624291 PMID:11410113 RGD PMID:11410113 vasoconstriction   IDA   4892557   RGD   vasoconstriction   ISO RGD:730848 1624291 PMID:2649896 RGD PMID:2649896 vein smooth muscle contraction   ISO RGD:730848 1624291 PMID:9422810 RGD PMID:9422810 vein smooth muscle contraction   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytoplasm   ISO RGD:730848 1624291 PMID:12379507 RGD PMID:12379507 cytoplasm   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 extracellular space   IDA   1625066   RGD   extracellular space   ISO RGD:730848 1624291 PMID:16820593 RGD PMID:16820593 extracellular space   ISO RGD:730848 1624291 PMID:15691296 RGD PMID:15691296 extracellular space   ISO RGD:730848 1624291 PMID:10770212 RGD PMID:10770212 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytokine activity   ISO RGD:730848 1624291 PMID:19767294 RGD PMID:19767294 cytokine activity   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 endothelin A receptor binding   IMP   1580292   RGD   endothelin A receptor binding   ISO RGD:730848 1624291 PMID:10770212 RGD PMID:10770212 endothelin B receptor binding   IMP   1580292   RGD   endothelin B receptor binding   ISO RGD:730848 1624291 PMID:10770212 RGD PMID:10770212 hormone activity   ISO RGD:730848 1624291 PMID:10770212 RGD PMID:10770212 hormone activity   IEA Ensembl:ENSP00000368683 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 hormone activity   ISO RGD:730848 1624291 PMID:2649896 RGD PMID:2649896 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) endothelin signaling pathway   ISS RGD:730848 1580323   RGD   endothelin signaling pathway   ISO RGD:730848 6484113   PID PID:200005 hypoxia inducible factor pathway   ISO RGD:730848 6484113   PID PID:200202 inflammatory response pathway   IDA   4892591   RGD   External Database Links KEGG Pathway HIF-1 signaling pathway Hypertrophic cardiomyopathy (HCM) Melanogenesis Neuroactive ligand-receptor interaction Vascular smooth muscle contraction Pathway Interaction Database AP-1 transcription factor network (PID:200137) EGFR-dependent Endothelin signaling events (PID:200112) Endothelins (PID:200005) HIF-1-alpha transcription factor network (PID:200202) Disease Annotations Acute Kidney Injury  (ISS) Albuminuria  (IEP) Asthma  (ISS) Brain Ischemia  (IEP) Bronchitis, Chronic  (ISS) Bronchopulmonary Dysplasia  (IEP) Cardiomyopathy, Hypertrophic  (IEP) Coronary Artery Disease  (ISS) Cystic Fibrosis  (ISS) Diabetes Mellitus, Experimental  (IEP) Diabetes Mellitus, Type 1  (ISS) Diabetes Mellitus, Type 2  (IEP,ISS) Diabetic Nephropathies  (ISS) Diabetic Retinopathy  (ISS) Dyspnea  (ISS) Erectile Dysfunction  (IEP) Glomerulonephritis, Membranoproliferative  (IEP) Heart Diseases  (IEP) Heart Failure  (ISS) Hepatopulmonary Syndrome  (IEP) Hypercapnia  (IEP,ISS) Hyperoxia  (IEP) Hypertension  (IEP,ISS) Hypertension, Portal  (IED) Hypertension, Pregnancy-Induced  (ISS) Hypertension, Pulmonary  (IEP,ISS) Hypogonadism  (IEP) Hypotension  (ISS) Kidney Failure, Chronic  (IEP) Liver Cirrhosis  (IEP) Mandibulofacial Dysostosis  (ISS) Myocardial Infarction  (ISS) Myocardial Reperfusion Injury  (IEP) Neoplasm Metastasis  (ISS) Nephrosis  (IEP) Obesity  (ISS) Optic Nerve Injuries  (IEP) Ovarian Neoplasms  (ISS) Pierre Robin Syndrome  (ISS) Pneumonia  (ISS) Pneumonia, Aspiration  (IEP) Polycystic Kidney, Autosomal Dominant  (ISS) Pulmonary Disease, Chronic Obstructive  (ISS) Pulmonary Embolism  (IEP) Pulmonary Fibrosis  (IEP,ISS) Renal Insufficiency  (IEP) Reperfusion Injury  (IEP) Respiratory Distress Syndrome, Adult  (IEP,ISS) Respiratory Insufficiency  (ISS) Scleroderma, Systemic  (ISS) Sleep Apnea, Obstructive  (IEP,ISS) stress related behavior  (IEP) Gene-Chemical Interaction Annotations (+)-catechin  (EXP,ISO) (-)-epigallocatechin 3-gallate  (ISO) (R)-mevalonic acid  (ISO) (R)-noradrenaline  (EXP) 1,3-dinitrobenzene  (EXP) 11-deoxycorticosterone  (EXP) 17alpha-ethynylestradiol  (EXP,ISO) 17beta-estradiol  (ISO) 1D-myo-inositol 1,4,5-trisphosphate  (EXP) 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2-butoxyethanol  (ISO) 3',5'-cyclic GMP  (EXP) 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP) 3-isobutyl-1-methyl-7H-xanthine  (ISO) 3H-1,2-dithiole-3-thione  (EXP) 4-hydroxynon-2-enal  (ISO) 5-fluorouracil  (ISO) 5-formyltetrahydrofolic acid  (ISO) 6alpha-methylprednisolone  (EXP) 8-bromo-3',5'-cyclic GMP  (EXP) acetylcholine  (EXP) aflatoxin B1  (ISO) aldosterone  (EXP) all-trans-retinoic acid  (EXP,ISO) amlodipine  (ISO) ammonium chloride  (EXP) ampicillin  (ISO) apocynin  (EXP,ISO) arsenite(3-)  (ISO) asbestos  (ISO) atenolol  (ISO) atropine  (ISO) benazepril  (EXP) benzo[a]pyrene  (ISO) bezafibrate  (EXP,ISO) bis(2-ethylhexyl) phthalate  (EXP) bisphenol A  (ISO) bosentan  (EXP,ISO) cadmium dichloride  (ISO) caffeine  (EXP) calcitriol  (ISO) calcium atom  (EXP,ISO) calcium(0)  (EXP,ISO) capsaicin  (ISO) carbon atom  (EXP) carbon monoxide  (EXP,ISO) carvedilol  (EXP,ISO) chenodeoxycholic acid  (EXP) cis-caffeic acid  (ISO) cisplatin  (EXP,ISO) clofibrate  (EXP) cobalt dichloride  (EXP,ISO) cocaine  (EXP,ISO) copper atom  (EXP) copper(0)  (EXP) copper(2+) sulfate  (ISO) corticosterone  (EXP) coumestrol  (ISO) cyclophosphamide  (ISO) cyclosporin A  (EXP) D-glucose  (EXP,ISO) dantrolene  (EXP) dapsone  (ISO) daunorubicin  (EXP) desferrioxamine B  (EXP) dexamethasone  (ISO) diazoxide  (EXP) dibutyl phthalate  (EXP,ISO) diclofenac  (ISO) dioxygen  (EXP,ISO) diprotium oxide  (ISO) doxorubicin  (EXP,ISO) dydrogesterone  (ISO) elemental carbon  (EXP) enalapril  (EXP) enalaprilat dihydrate  (ISO) ethanol  (EXP,ISO) formaldehyde  (ISO) fructose  (EXP) fulvestrant  (ISO) genistein  (ISO) glucose  (EXP,ISO) heparin  (EXP,ISO) histamine  (ISO) hydralazine  (EXP) hydrogen chloride  (EXP) hydrogen peroxide  (EXP,ISO) indomethacin  (EXP,ISO) iodixanol  (EXP) iopromide  (EXP) irbesartan  (ISO) iron atom  (EXP) isoprenaline  (EXP) isosorbide dinitrate  (ISO) L-ascorbic acid  (ISO) leflunomide  (ISO) leukotriene C4  (ISO) lignoceric acid  (ISO) linalool  (ISO) lisinopril dihydrate  (ISO) losartan  (EXP,ISO) LY294002  (EXP) melphalan  (ISO) menadione  (ISO) metoprolol  (EXP) mevalonic acid  (ISO) mono(2-ethylhexyl) phthalate  (EXP) monocrotaline  (EXP) N-acetyl-L-cysteine  (EXP,ISO) N-nitrosodiethylamine  (EXP) naphthalene  (ISO) nifedipine  (EXP) nimesulide  (EXP) nitric oxide  (EXP,ISO) nitroglycerin  (EXP,ISO) nitroprusside  (EXP) oleic acid  (ISO) olmesartan  (EXP) ouabain  (EXP) ozone  (EXP) palmitic acid  (ISO) paracetamol  (EXP,ISO) paraquat  (EXP,ISO) paricalcitol  (EXP) PD123319  (EXP) phenobarbital  (ISO) phenylephrine  (EXP,ISO) phosgene  (EXP) potassium atom  (ISO) potassium chloride  (EXP) pravastatin  (EXP,ISO) prazosin  (EXP) propofol  (EXP,ISO) prostaglandin E2  (EXP,ISO) quercetin  (ISO) quinapril hydrochloride  (ISO) resveratrol  (EXP,ISO) rifampicin  (ISO) Ro 31-8220  (EXP) rolipram  (EXP) rosiglitazone  (ISO) rotenone  (EXP) sevoflurane  (EXP) sildenafil  (ISO) silicon dioxide  (ISO) simvastatin  (EXP,ISO) sirolimus  (EXP) sodium atom  (ISO) sodium chloride  (EXP) staurosporine  (EXP) stearic acid  (ISO) stilbene-4,4'-diol  (ISO) streptozocin  (EXP) sulfur dioxide  (EXP) superoxide  (EXP) tacrolimus hydrate  (EXP) tamibarotene  (ISO) tamoxifen  (ISO) telmisartan  (EXP) tert-butyl hydroperoxide  (ISO) testosterone  (EXP,ISO) tetrachloromethane  (EXP,ISO) theophylline  (ISO) thymidine  (ISO) trans-resveratrol  (EXP,ISO) troglitazone  (ISO) ursodeoxycholic acid  (ISO) valproic acid  (ISO) valsartan  (EXP) vanadyl sulfate  (ISO) water  (ISO) wortmannin  (ISO) zafirlukast  (ISO) zinc atom  (ISO) zinc(0)  (ISO) Gene Ontology Annotations Biological Process artery smooth muscle contraction  (ISO) body fluid secretion  (IEA) calcium-mediated signaling  (IEA,ISO) cartilage development  (IEA) cell growth  (IDA) cell surface receptor signaling pathway  (ISO) cell-cell signaling  (ISO) cellular response to interleukin-1  (IEP) cellular response to tumor necrosis factor  (IEP) dorsal/ventral pattern formation  (IEA) elevation of cytosolic calcium ion concentration  (IDA,ISO) elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  (IEA) epithelial fluid transport  (IDA) G-protein coupled receptor signaling pathway  (ISO) glucose transport  (IEA) heart development  (IEA) histamine secretion  (IDA) in utero embryonic development  (IEA) inositol phosphate-mediated signaling  (IEA,ISO) intracellular protein kinase cascade  (IDA) maternal process involved in parturition  (IEP) membrane depolarization  (IMP) middle ear morphogenesis  (IEA) multicellular organismal aging  (IEP) negative regulation of cAMP biosynthetic process  (IEA) negative regulation of cellular protein metabolic process  (IEA,ISO) negative regulation of hormone secretion  (IDA) negative regulation of nitric-oxide synthase biosynthetic process  (IEA,ISO) negative regulation of smooth muscle cell apoptotic process  (IDA) negative regulation of transcription from RNA polymerase II promoter  (IEA,ISO) neural crest cell development  (IEA) neutrophil chemotaxis  (ISO) nitric oxide transport  (IEA,ISO) patterning of blood vessels  (IEA) peptide hormone secretion  (IEA,ISO) phosphatidylinositol 3-kinase cascade  (IEA,ISO) phospholipase D-activating G-protein coupled receptor signaling pathway  (IEA) positive regulation of cardiac muscle hypertrophy  (IEA,ISO) positive regulation of cell migration  (ISO) positive regulation of cell proliferation  (IDA,ISO,TAS) positive regulation of cell size  (IEA,ISO) positive regulation of heart rate  (IEA,ISO) positive regulation of hormone secretion  (IEA,ISO) positive regulation of JUN kinase activity  (IEA,ISO) positive regulation of MAP kinase activity  (ISO) positive regulation of mitosis  (IEA,ISO) positive regulation of neutrophil chemotaxis  (IDA) positive regulation of odontogenesis  (IDA) positive regulation of prostaglandin-endoperoxide synthase activity  (IEA,ISO) positive regulation of receptor biosynthetic process  (IEA,ISO) positive regulation of renal sodium excretion  (IEA) positive regulation of sarcomere organization  (IEA,ISO) positive regulation of smooth muscle cell proliferation  (IEA,ISO) positive regulation of smooth muscle contraction  (IDA) positive regulation of urine volume  (IEA) prostaglandin biosynthetic process  (IEA,ISO) protein kinase C deactivation  (IEA,ISO) protein kinase C-activating G-protein coupled receptor signaling pathway  (IEA) regulation of blood pressure  (IMP) regulation of pH  (IEA) regulation of sensory perception of pain  (IDA) regulation of systemic arterial blood pressure by endothelin  (IEA,ISO) regulation of vasoconstriction  (IEA) respiratory gaseous exchange  (IEA) response to amino acid stimulus  (IEP) response to drug  (IEP) response to hypoxia  (IEP) response to lipopolysaccharide  (IEP) response to nicotine  (IEP) response to testosterone stimulus  (IEP) rhythmic excitation  (IEA) sensory perception of pain  (IDA) superoxide anion generation  (IDA) vasoconstriction  (IDA,ISO) vein smooth muscle contraction  (IEA,ISO) Cellular Component cytoplasm  (IEA,ISO) extracellular space  (IDA,ISO) Molecular Function cytokine activity  (IEA,ISO) endothelin A receptor binding  (IMP,ISO) endothelin B receptor binding  (IMP,ISO) hormone activity  (IEA,ISO) Molecular Pathway Annotations endothelin signaling pathway  (ISO,ISS) hypoxia inducible factor pathway  (ISO) inflammatory response pathway  (IDA) External Database Links KEGG Pathway HIF-1 signaling pathway Hypertrophic cardiomyopathy (HCM) Melanogenesis Neuroactive ligand-receptor interaction Vascular smooth muscle contraction Pathway Interaction Database AP-1 transcription factor network (PID:200137) EGFR-dependent Endothelin signaling events (PID:200112) Endothelins (PID:200005) HIF-1-alpha transcription factor network (PID:200202) References - curated 1. 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Biological Process Cancer Diseases Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Biological Process Diabetes Diseases Diabetes Pathways Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Biological Process Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Biological Process Respiratory Diseases Respiratory Pathways Genomics Comparative Map Data Edn1   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 17 p12   NCBI RGSC Genome Assembly v5.0 17 24,118,009 - 24,124,009 - NCBI RGSC Genome Assembly v3.4 17 28,303,886 - 28,309,775 - NCBI Rat Celera Assembly 17 22,134,975 - 22,140,901 - NCBI Genome Assembly 3.1 17 28,306,726 - 28,312,616 - NCBI EDN1   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 6 12,213,196 - 12,220,096 + NCBI Human Genome Assembly HuRef 6 12,222,160 - 12,229,052 + NCBI Human Genome Assembly GRCh37 6 12,290,529 - 12,297,427 + NCBI Human Genome Assembly Build 36 6 12,398,515 - 12,405,413 + NCBI Human Cytogenetic Map 6 p24.1   NCBI Human Genome Assembly 6 12,398,644 - 12,404,761   NCBI Position Markers D17Mco5   Map Chr Position Strand Source Rat Cytogenetic Map 17 p12   UniSTS RGSC Genome Assembly v5.0 17 24,122,311 - 24,122,488   NCBI RGSC Genome Assembly v5.0 17 24,122,310 - 24,122,487   NCBI RGSC Genome Assembly v3.4 17 28,308,076 - 28,308,253   RGD RGSC Genome Assembly v3.4 17 28,308,077 - 28,308,254   UniSTS Rat Celera Assembly 17 22,139,165 - 22,139,380   UniSTS Genome Assembly 3.1 17 28,310,917 - 28,311,094   RGD QTLs in Region (RGSC Genome Assembly v3.4) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 631207 Niddm41 Non-insulin dependent diabetes mellitus QTL 41 Glucose level postprandial 17 1 43786390 Rat 1354658 Spl8 Serum phospholipid level QTL 8 3.8 Lipid level serum phospholipids 17 1 71570057 Rat 1354581 Bp247 Blood pressure QTL 247 4.5 Blood pressure pulse pressure 17 1 81039660 Rat 1354662 Rf49 Renal function QTL 49 2.9 Creatinine level serum 17 1 81039660 Rat 1300123 Bp194 Blood pressure QTL 194 2.82 Blood pressure salt-loaded mean arterial 17 7696509 41028541 Rat 1354613 Kidm14 Kidney mass QTL 14 6.2 Kidney mass left kidney mass 17 9988620 42344987 Rat 1354596 Bw32 Body weight QTL 32 4.5 Body weight 17 9988620 71570057 Rat 1354630 Cm34 Cardiac mass QTL 34 8.7 Cardiac mass left ventricle 17 9988620 81039660 Rat 1354638 Insul1 Insulin level QTL 1 4.8 Insulin level serum 17 9988620 81039660 Rat 1354651 Lmblg2 Limb length QTL 2 6 Limb morphology tibia length 17 9988620 81039660 Rat 2293648 Bmd31 Bone mineral density QTL 31 4.5 .0001 Bone mineral density 17 10044240 33277509 Rat 2293664 Bmd28 Bone mineral density QTL 28 5.1 .0001 Bone mineral density Trabecular volumetric bone mineral density 17 10044240 33277509 Rat 2303627 Vencon8 Ventilatory control QTL 8 .001 Ventilatory control re-oxygenation after hypoxia 17 10777341 55777341 Rat 70184 BpQTLcluster14 Blood pressure QTL cluster 14 3.38 Blood pressure systolic 17 14575011 38353858 Rat 2303561 Bw91 Body weight QTL 91 2 Body weight 17 15228042 60228042 Rat 1582241 Bw70 Body weight QTL 70 4.6 .0003 Body weight 17 15245341 29604237 Rat 1582245 Bw73 Body weight QTL 73 4.6 .0004 Body weight 17 15245341 29604237 Rat 1582258 Bw76 Body weight QTL 76 4.6 .0005 Body weight 17 15245341 29604237 Rat 1582199 Insul5 Insulin level QTL 5 3.4 .0119 Insulin level 17 15245341 29604237 Rat 1582208 Kidm32 Kidney mass QTL 32 3.9 .0018 Kidney mass 17 15245341 29604237 Rat 1582224 Epfw4 Epididymal fat weight QTL 4 3.5 .0058 Epididymal fat weight 17 15245341 29604237 Rat 1582225 Bw67 Body weight QTL 67 6.2 .0001 Body weight 17 15245341 29604237 Rat 1582226 Bw64 Body weight QTL 64 4.2 .0017 Body weight 17 15245341 29604237 Rat 1331720 Rf43 Renal function QTL 43 2.881 Renal function renal vascular resistance 17 21286331 28903238 Rat 1331765 Hrtrt15 Heart rate QTL 15 4.094 Heart rate 17 21286331 36519723 Rat 2300002 Iddm36 Insulin dependent diabetes mellitus QTL 36 1.98 Glucose Level insulin Dependent 17 22932286 47628829 Rat 1354629 Scl31 Serum cholesterol level QTL 31 4.1 Lipid level serum cholesterol 17 26570057 71570057 Rat 1354640 Scl32 Serum cholesterol level QTL 32 5.4 Lipid level HDL cholesterol 17 26570057 71570057 Rat 1354654 Spl7 Serum phospholipid level QTL 7 5.5 Lipid level serum phospholipids 17 26570057 71570057 Rat 1354659 Spl6 Serum phospholipid level QTL 6 3.9 Lipid level VLDL 17 26570057 71570057 Rat 1354628 Stl13 Serum triglyceride level QTL 13 3.8 Lipid level total triglycerides 17 27118351 71570057 Rat 70157 Niddm32 Non-insulin dependent diabetes mellitus QTL 32 4.34 Glucose level postprandial 17 28303886 59104944 Rat Related Rat Strains The following Strains have been annotated to Edn1 SD Sequence Nucleotide Sequences Nucleotide RefSeqs NM_012548 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AABR06090876 (Get FASTA) Search GEO for Microarray Profiles   AAHX01090634 (Get FASTA) Search GEO for Microarray Profiles   AF122903 (Get FASTA) Search GEO for Microarray Profiles   CH473977 (Get FASTA) Search GEO for Microarray Profiles   M64711 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_012548 RefSeq Status: VALIDATED Type: CODING Protein Acc Id: NP_036680 Peptide Label: preproprotein Position: Map Chr Position Strand Source RGSC Genome Assembly v5.0 17 24,118,009 - 24,124,009 - NCBI RGSC Genome Assembly v3.4 17 28,303,886 - 28,309,775 - RGD Rat Celera Assembly 17 22,134,975 - 22,140,901 - RGD Protein Sequences Protein RefSeqs NP_036680 (Get FASTA) GenBank Protein AAA41129 (Get FASTA)   AAF31762 (Get FASTA)   EDL98206 (Get FASTA)   P22388 (Get FASTA) Strain Variation Strain Sequence Variants ACI/Eur (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 ACI/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN-Lx (ICL) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: SOLID Secondary Analysis: BWA, GATK, Samtools Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: MC-A654-5QB00 BN-Lx (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/NHsdMcwi (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/SsN (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Buf/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) COP/Crl (MCW & UW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Univiersity of Wisconsin (Jim Shull) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 Breeder: Charles River Grant Information: NIH (CA77876) F344/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHH/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 FHH/EurMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHL/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 GH/OmrMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 LE/Stm (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Dr. Tadao Serikawa, Kyoto Japan. Grant Information: EURATRANS (HEALTH-F4-2010-241504) M520/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) MR/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHR/Olalpcv (ICL) Visual CSV TAB Printer Sequenced By: Imperial College London (Dr Timothy Aitman) University of British Columbia (Dr. Steven Jones) Platform: Illumina Hi-seq 2000 and GAII Secondary Analysis: BWA, GATK Breeder: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague Grant Information: LSHG-CT-2005-019015, HEALTH-F4-2010-241504 SHR/Olalpcv (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: Illumina Secondary Analysis: GATK Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHRSP/Gcrc (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruch Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: University of Glasgow, Anna Dominiczak Grant Information: EURATRANS (HEALTH-F4-2010-241504) SR/JrHsd (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Breeder: Harlan SS/JrHsdMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Grant Information: R01 HL089930 SS/JrHsdMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) WKY/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) WN/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSRNOG00000014361 ENTREZGENE, UniProtKB/Swiss-Prot Ensembl Protein ENSRNOP00000019361 ENTREZGENE, UniProtKB/Swiss-Prot Ensembl Transcript ENSRNOT00000019361 ENTREZGENE, UniProtKB/Swiss-Prot Entrez Gene 24323 ENTREZGENE Germonline ENSRNOG00000014361 UniProtKB/Swiss-Prot HomoloGene Group ID 1476 ENTREZGENE InterPro Bibrotoxin/Sarafotoxin-D UniProtKB/Swiss-Prot   Endothelin_toxin_CS UniProtKB/Swiss-Prot   Endothln_like_toxin UniProtKB/Swiss-Prot IPI IPI00206210 UniProtKB/Swiss-Prot KEGG Report rno:24323 ENTREZGENE, UniProtKB/Swiss-Prot Pfam Endothelin UniProtKB/Swiss-Prot PRINTS ENDOTHELIN UniProtKB/Swiss-Prot PROSITE ENDOTHELIN UniProtKB/Swiss-Prot SMART END UniProtKB/Swiss-Prot UniGene Rn.10918 ENTREZGENE UniProt EDN1_RAT UniProtKB/Swiss-Prot   Q9JLX8_RAT UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2002-06-10 Edn1  endothelin 1      Symbol and Name status set to approved 1490 APPROVED RGD Curation Notes Note Type Note Reference gene_disease associated with chronic obstructive pulmonary disease (COPD), hypoxic pulmonary vasoconstriction (HPV), pulmonary arterial remodeling, and polycythemia 625753 gene_disease contributes to cardiovascular diseases, participates in the pathogenesis of deoxycorticosterone acetate (DOCA)-salt-induced hypertension 625753 gene_drugs DOCA treated rats had a higher levels of renal, urinary and aortic expression which was normalized by the treatment with Ednra antagonist ABT-627 625753 gene_expression expressed in lung and cultured pulmonary artery endothelial cells 625753 gene_function acts as a vasoactive and mitogenic peptide   gene_other intravenous administration causes a decrease in the arterial pressure 625753 gene_process acts as a vasoactive and mitogenic peptide 625753 gene_process potent vasopressor found in the vascular endothelial cells 628459 gene_process potent vasopressor found in the vascular endothelial cells 628515 gene_process potent vasopressor found in the vascular endothelial cells 628516 gene_process potent vasopressor found in the vascular endothelial cells 628517 gene_process role in the development of chronic hypoxia induced pulmonary hypertension, acts as a vasoconstrictor to augment hypoxic pulmonary vasoconstriction [HPV] 625753 gene_regulation lungs of ovariectomized (OVX) rats showed an increase in prepro- endothelin mRNA levels when exposed to hypoxia and increase was blocked by ovarian hormone 17-B-estradiol (E2B) 625753 gene_regulation gene expression is mediated by transcription factor hypoxia-inducible factor 1 (HIF-1) 625753 gene_regulation promoter activity was increased by transcriptional coactivator cAMP response element binding protein (CREB) binding protein (CBP)/p300 625753 gene_regulation increase in the plasma endothelin levels has no effect on the arterial pressure in the homozygous spotting lethal rats 625753

More on Edn1 Entrez Gene Ensembl Gene Genome Browser NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 2532 Created: 2000-05-25 Species: Rattus norvegicus Last Modified: 2013-04-16 Status: ACTIVE