Gene: Grk2 (G protein-coupled receptor kinase 2) Rattus norvegicus
Symbol: Grk2
Name: G protein-coupled receptor kinase 2
Description: ENCODES a protein that exhibits beta-adrenergic receptor kinase activity; G-protein coupled receptor kinase activity; Edg-2 lysophosphatidic acid receptor binding (ortholog); INVOLVED IN aging; desensitization of G-protein coupled receptor protein signaling pathway; follicle-stimulating hormone signaling pathway; PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; ASSOCIATED WITH Heart Failure; Hyperglycemia; Hypertension; FOUND IN apical plasma membrane; axon; basolateral plasma membrane; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,4-dinitrotoluene; 2,6-dinitrotoluene
Type: protein-coding
Also known as: Adrbk1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; BARK1; beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-adrenergic receptor kinase 1, beta ARK1; beta-ARK-1; G-protein-coupled receptor kinase 2; G-protein-linked receptor kinase (beta adrenergic receptor kinase 1); GRK-2
Homo sapiens (human) : GRK2 (G protein-coupled receptor kinase 2)  HGNC  AGR
Mus musculus (house mouse) : Grk2 (G protein-coupled receptor kinase 2)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Grk2 (G protein-coupled receptor kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK2 (G protein-coupled receptor kinase 2)
Canis lupus familiaris (dog) : GRK2 (G protein-coupled receptor kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk2 (G protein-coupled receptor kinase 2)
more info ...
Is Marker For: Strains:   SHHF  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01219,536,220 - 219,544,329 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01226,406,333 - 226,414,442 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,873,002 - 206,892,868 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11207,026,454 - 207,034,564 (-)NCBI
Celera1199,125,797 - 199,145,728 (-)NCBICelera
Cytogenetic Map1q43NCBI
RH 3.4 Map11560.2RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Grk2
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2062
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-11-28
Status: ACTIVE