Gene: Nr1i3 (nuclear receptor subfamily 1, group I, member 3) Rattus norvegicus
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Description: ENCODES a protein that exhibits DNA binding (ortholog); RNA polymerase II regulatory region sequence-specific DNA binding (ortholog); transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (ortholog); INVOLVED IN osteoblast differentiation; negative regulation of transcription, DNA-templated (ortholog); positive regulation of transcription from RNA polymerase II promoter (ortholog); ASSOCIATED WITH Diabetes Mellitus, Experimental; Adenoma, Liver Cell (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm; nucleus; cytosol (ortholog); INTERACTS WITH (+)-artemisinin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CAR; constitutive androstane receptor; MGC108525; nuclear receptor constitutive active receptor; nuclear receptor subfamily 1 group I member 3; strain Fischer nuclear receptor (CAR)
Homo sapiens (human) : NR1I3 (nuclear receptor subfamily 1 group I member 3)  HGNC  AGR
Mus musculus (house mouse) : Nr1i3 (nuclear receptor subfamily 1, group I, member 3)  MGI
Chinchilla lanigera (long-tailed chinchilla) : Nr1i3 (nuclear receptor subfamily 1 group I member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NR1I3 (nuclear receptor subfamily 1 group I member 3)
Canis lupus familiaris (dog) : NR1I3 (nuclear receptor subfamily 1 group I member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr1i3 (nuclear receptor subfamily 1 group I member 3)
more info ...
Allele / Splice: Nr1i3 em1Sage  
Genetic Models: SD-Nr1i2 em1SageNr1i3 em1Sage SD-Nr1i2 em1SageNr1i3 em1SageAhrem1Sage SD-Nr1i3 em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01389,585,072 - 89,591,278 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01394,211,961 - 94,218,143 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41387,104,241 - 87,108,563 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11387,292,773 - 87,297,730 (+)NCBI
Celera1383,264,145 - 83,269,088 (+)NCBI
Cytogenetic Map13q24NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nr1i3
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 621400
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE