Gene: Nr1i3 (nuclear receptor subfamily 1, group I, member 3) Rattus norvegicus
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Description: ENCODES a protein that exhibits DNA binding (ortholog); RNA polymerase II regulatory region sequence-specific DNA binding (ortholog); transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (ortholog); INVOLVED IN osteoblast differentiation; negative regulation of transcription, DNA-templated (ortholog); positive regulation of transcription from RNA polymerase II promoter (ortholog); ASSOCIATED WITH Diabetes Mellitus, Experimental; Adenoma, Liver Cell (ortholog); Diabetes Mellitus (ortholog); FOUND IN cytoplasm; nucleus; cytosol (ortholog); INTERACTS WITH (+)-artemisinin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CAR; constitutive androstane receptor; MGC108525; nuclear receptor constitutive active receptor; nuclear receptor subfamily 1 group I member 3; strain Fischer nuclear receptor (CAR)
Homo sapiens (human) : NR1I3 (nuclear receptor subfamily 1 group I member 3)  HGNC
Mus musculus (house mouse) : Nr1i3 (nuclear receptor subfamily 1, group I, member 3)  MGI
Chinchilla lanigera (long-tailed chinchilla) : Nr1i3 (nuclear receptor subfamily 1 group I member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NR1I3 (nuclear receptor subfamily 1 group I member 3)
Canis lupus familiaris (dog) : NR1I3 (nuclear receptor subfamily 1 group I member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr1i3 (nuclear receptor subfamily 1 group I member 3)
more info ...
Allele / Splice: Nr1i3 em1Sage  
Genetic Models: SD-Nr1i2 em1SageNr1i3 em1Sage SD-Nr1i2 em1SageNr1i3 em1SageAhrem1Sage SD-Nr1i3 em1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01389,585,072 - 89,591,278 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01394,211,961 - 94,218,143 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41387,104,241 - 87,108,563 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11387,292,773 - 87,297,730 (+)NCBI
Celera1383,264,145 - 83,269,088 (+)NCBI
Cytogenetic Map13q24NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nr1i3
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 621400
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-05-30
Status: ACTIVE