Prkacb (protein kinase cAMP-activated catalytic subunit beta) - Rat Genome Database

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Gene: Prkacb (protein kinase cAMP-activated catalytic subunit beta) Rattus norvegicus
Analyze
Symbol: Prkacb
Name: protein kinase cAMP-activated catalytic subunit beta
RGD ID: 1310574
Description: Enables cAMP-dependent protein kinase activity. Involved in negative regulation of meiotic cell cycle. Located in perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Biomarker of brain ischemia. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta); PARTICIPATES IN adenosine signaling pathway; dopamine signaling pathway; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cAMP-dependent protein kinase catalytic subunit beta; LOC310986; PKA C-beta; Prkacb_predicted; protein kinase, cAMP dependent, catalytic, beta; protein kinase, cAMP-dependent, beta catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82238,297,140 - 238,389,317 (-)NCBIGRCr8
mRatBN7.22235,636,878 - 235,726,928 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2235,636,885 - 235,726,198 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2243,435,379 - 243,522,815 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02241,326,025 - 241,413,467 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02236,193,035 - 236,280,486 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02252,602,197 - 252,691,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,605,307 - 252,691,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02271,129,418 - 271,218,985 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,949,303 - 245,035,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2227,617,114 - 227,701,913 (-)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
androstane-3,17-diol  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cannabidiol  (ISO)
capecitabine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clozapine  (EXP)
colforsin daropate hydrochloride  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diclofenac  (ISO)
diuron  (EXP)
Doramectin  (EXP)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fipronil  (EXP)
folic acid  (ISO)
formononetin  (ISO)
FR900359  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
haloperidol  (EXP)
heptanal  (ISO)
hexanal  (ISO)
hydrogen cyanide  (ISO)
hydrogen sulfide  (ISO)
ivermectin  (ISO)
Kemptide  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
Methylazoxymethanol acetate  (EXP)
motexafin gadolinium  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nitrates  (EXP)
nonanal  (ISO)
octanal  (ISO)
oxybenzone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
propanal  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sulindac  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc acetate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Differential effects of haloperidol and clozapine on cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain. Dwivedi Y, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):197-209.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning. Huang YY, etal., Cell. 1995 Dec 29;83(7):1211-22.
4. Regulation of mRNA expression involved in Ras and PKA signal pathways during rat hypoglossal nerve regeneration. Kiryu S, etal., Brain Res Mol Brain Res. 1995 Mar;29(1):147-56.
5. An active protein kinase A (PKA) is involved in meiotic arrest of rat growing oocytes. Kovo M, etal., Reproduction. 2006 Jul;132(1):33-43.
6. Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells. Manni S, etal., J Biol Chem. 2008 Aug 29;283(35):24145-54. Epub 2008 Jun 12.
7. Impairment of cerebral cAMP-mediated signal transduction system and of spatial memory function after microsphere embolism in rats. Nagakura A, etal., Neuroscience. 2002;113(3):519-28.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Isolation of a complementary DNA encoding the catalytic subunit of protein kinase A and studies on the expression of this sequence in rat hepatomas and regenerating liver. Roth JS, etal., Cancer Res. 1990 Mar 15;50(6):1675-80.
14. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
15. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
16. Stimulation of c-Rel transcriptional activity by PKA catalytic subunit beta. Yu SH, etal., J Mol Med. 2004 Sep;82(9):621-8. Epub 2004 Jun 9.
Additional References at PubMed
PMID:1610898   PMID:9368018   PMID:9521123   PMID:12420224   PMID:12628924   PMID:18385332   PMID:19197368   PMID:21399614   PMID:21423175   PMID:21880142   PMID:22007132   PMID:23376485  
PMID:23533145   PMID:32357304  


Genomics

Comparative Map Data
Prkacb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82238,297,140 - 238,389,317 (-)NCBIGRCr8
mRatBN7.22235,636,878 - 235,726,928 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2235,636,885 - 235,726,198 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2243,435,379 - 243,522,815 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02241,326,025 - 241,413,467 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02236,193,035 - 236,280,486 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02252,602,197 - 252,691,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,605,307 - 252,691,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02271,129,418 - 271,218,985 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,949,303 - 245,035,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2227,617,114 - 227,701,913 (-)NCBICelera
Cytogenetic Map2q44NCBI
PRKACB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38184,078,079 - 84,238,498 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl184,078,062 - 84,238,498 (+)EnsemblGRCh38hg38GRCh38
GRCh37184,543,762 - 84,704,181 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36184,316,333 - 84,476,769 (+)NCBINCBI36Build 36hg18NCBI36
Celera182,787,965 - 82,948,395 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef182,654,090 - 82,814,484 (+)NCBIHuRef
CHM1_1184,658,575 - 84,819,019 (+)NCBICHM1_1
T2T-CHM13v2.0183,918,534 - 84,078,964 (+)NCBIT2T-CHM13v2.0
Prkacb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393146,435,334 - 146,518,691 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3146,435,329 - 146,518,745 (-)EnsemblGRCm39 Ensembl
GRCm383146,729,579 - 146,812,946 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3146,729,574 - 146,812,990 (-)EnsemblGRCm38mm10GRCm38
MGSCv373146,392,543 - 146,475,910 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363146,666,965 - 146,750,316 (-)NCBIMGSCv36mm8
Celera3153,182,525 - 153,265,941 (-)NCBICelera
Cytogenetic Map3H2NCBI
cM Map372.28NCBI
Prkacb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554239,629,378 - 9,747,820 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554239,630,308 - 9,747,820 (-)NCBIChiLan1.0ChiLan1.0
PRKACB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21142,704,501 - 142,865,759 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11141,858,945 - 142,019,573 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01116,625,640 - 116,786,396 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1185,574,094 - 85,647,446 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl185,487,681 - 85,644,253 (+)Ensemblpanpan1.1panPan2
PRKACB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1663,615,445 - 63,729,386 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl663,618,323 - 63,730,146 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha666,263,759 - 66,377,569 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0664,155,572 - 64,269,668 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl664,155,572 - 64,269,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1663,683,378 - 63,796,798 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0663,652,236 - 63,766,014 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0664,158,621 - 64,272,439 (-)NCBIUU_Cfam_GSD_1.0
Prkacb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505894,841,492 - 94,952,128 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366081,353,897 - 1,464,636 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366081,353,905 - 1,464,636 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKACB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6129,520,376 - 129,635,733 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16129,520,397 - 129,636,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26119,719,887 - 119,778,443 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKACB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12049,109,774 - 49,273,200 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2049,108,425 - 49,178,806 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603368,486,789 - 68,652,007 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkacb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474213,242,593 - 13,357,986 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474213,243,248 - 13,357,873 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkacb
499 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:32
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000068739
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

Markers in Region
RH133906  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,975,550 - 181,975,757 (+)MAPPERmRatBN7.2
Rnor_6.01198,801,547 - 198,801,753NCBIRnor6.0
Rnor_5.01205,799,940 - 205,800,146UniSTSRnor5.0
RGSC_v3.41186,620,151 - 186,620,357UniSTSRGSC3.4
Celera1179,628,164 - 179,628,370UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map2q44UniSTS
X61434  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,639,593 - 235,639,757 (+)MAPPERmRatBN7.2
Rnor_6.02252,605,036 - 252,605,199NCBIRnor6.0
Rnor_5.02271,132,135 - 271,132,298UniSTSRnor5.0
RGSC_v3.42244,949,032 - 244,949,195UniSTSRGSC3.4
Celera2227,616,843 - 227,617,006UniSTS
Cytogenetic Map2q44UniSTS
RH139283  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,640,477 - 235,640,719 (+)MAPPERmRatBN7.2
Rnor_6.02252,605,920 - 252,606,161NCBIRnor6.0
Rnor_5.02271,133,019 - 271,133,260UniSTSRnor5.0
RGSC_v3.42244,949,916 - 244,950,157UniSTSRGSC3.4
Celera2227,617,727 - 227,617,968UniSTS
Cytogenetic Map2q44UniSTS
BF417257  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,702,694 - 235,702,787 (+)MAPPERmRatBN7.2
Rnor_6.02252,668,523 - 252,668,615NCBIRnor6.0
Rnor_5.02271,195,622 - 271,195,714UniSTSRnor5.0
RGSC_v3.42245,011,907 - 245,011,999UniSTSRGSC3.4
Celera2227,678,543 - 227,678,635UniSTS
Cytogenetic Map2q44UniSTS
Prkacb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,655,423 - 235,656,709 (+)MAPPERmRatBN7.2
mRatBN7.21181,975,264 - 181,975,344 (+)MAPPERmRatBN7.2
Rnor_6.01198,801,261 - 198,801,340NCBIRnor6.0
Rnor_6.02252,620,866 - 252,622,151NCBIRnor6.0
Rnor_5.02271,147,965 - 271,149,250UniSTSRnor5.0
Rnor_5.01205,799,654 - 205,799,733UniSTSRnor5.0
RGSC_v3.41186,619,865 - 186,619,944UniSTSRGSC3.4
RGSC_v3.42244,964,862 - 244,966,147UniSTSRGSC3.4
Celera2227,632,322 - 227,633,607UniSTS
Celera1179,627,878 - 179,627,957UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map2q44UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 55 39 19 39 8 10 74 35 35 11 8
Low 1 2 2 2 1 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000068739   ⟹   ENSRNOP00000062228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,636,885 - 235,726,198 (-)Ensembl
Rnor_6.0 Ensembl2252,605,307 - 252,691,886 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109432   ⟹   ENSRNOP00000085004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,636,885 - 235,668,313 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117576   ⟹   ENSRNOP00000092040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,636,885 - 235,681,232 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119870   ⟹   ENSRNOP00000097634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,636,885 - 235,666,414 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119887   ⟹   ENSRNOP00000086804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,636,885 - 235,693,675 (-)Ensembl
RefSeq Acc Id: NM_001077645   ⟹   NP_001071113
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82238,300,127 - 238,386,315 (-)NCBI
mRatBN7.22235,639,865 - 235,726,052 (-)NCBI
Rnor_6.02252,605,307 - 252,691,886 (-)NCBI
Rnor_5.02271,129,418 - 271,218,985 (-)NCBI
RGSC_v3.42244,949,303 - 245,035,266 (-)RGD
Celera2227,617,114 - 227,701,913 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233451   ⟹   XP_006233513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82238,297,140 - 238,354,036 (-)NCBI
mRatBN7.22235,636,878 - 235,693,469 (-)NCBI
Rnor_6.02252,602,197 - 252,659,842 (-)NCBI
Rnor_5.02271,129,418 - 271,218,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233452   ⟹   XP_006233514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82238,297,140 - 238,353,341 (-)NCBI
mRatBN7.22235,636,878 - 235,681,193 (-)NCBI
Rnor_6.02252,602,197 - 252,648,734 (-)NCBI
Rnor_5.02271,129,418 - 271,218,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233453   ⟹   XP_006233515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82238,297,140 - 238,353,341 (-)NCBI
mRatBN7.22235,636,878 - 235,680,776 (-)NCBI
Rnor_6.02252,602,197 - 252,646,399 (-)NCBI
Rnor_5.02271,129,418 - 271,218,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101884   ⟹   XP_038957812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82238,379,688 - 238,389,317 (-)NCBI
mRatBN7.22235,719,433 - 235,726,928 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001071113   ⟸   NM_001077645
- UniProtKB: P68182 (UniProtKB/Swiss-Prot),   A0A8I6GBC1 (UniProtKB/TrEMBL),   A6HWE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233513   ⟸   XM_006233451
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A4F6 (UniProtKB/TrEMBL),   A0A8I6GBC1 (UniProtKB/TrEMBL),   A6HWF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233514   ⟸   XM_006233452
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GBC1 (UniProtKB/TrEMBL),   A6HWF1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233515   ⟸   XM_006233453
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AV42 (UniProtKB/TrEMBL),   A6HWF2 (UniProtKB/TrEMBL),   Q05759 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062228   ⟸   ENSRNOT00000068739
RefSeq Acc Id: XP_038957812   ⟸   XM_039101884
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000086804   ⟸   ENSRNOT00000119887
RefSeq Acc Id: ENSRNOP00000097634   ⟸   ENSRNOT00000119870
RefSeq Acc Id: ENSRNOP00000085004   ⟸   ENSRNOT00000109432
RefSeq Acc Id: ENSRNOP00000092040   ⟸   ENSRNOT00000117576
Protein Domains
AGC-kinase C-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P68182-F1-model_v2 AlphaFold P68182 1-351 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310574 AgrOrtholog
BioCyc Gene G2FUF-50889 BioCyc
Ensembl Genes ENSRNOG00000004978 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023932 UniProtKB/Swiss-Prot
  ENSRNOG00060000873 UniProtKB/Swiss-Prot
  ENSRNOG00065012881 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000068739 ENTREZGENE
  ENSRNOT00000068739.2 UniProtKB/Swiss-Prot
  ENSRNOT00000109432.1 UniProtKB/TrEMBL
  ENSRNOT00000117576.1 UniProtKB/TrEMBL
  ENSRNOT00000119870.1 UniProtKB/TrEMBL
  ENSRNOT00000119887.1 UniProtKB/TrEMBL
  ENSRNOT00055041233 UniProtKB/Swiss-Prot
  ENSRNOT00060001112 UniProtKB/Swiss-Prot
  ENSRNOT00065021101 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STKc_PKA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:293508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Prkacb ENTREZGENE
PANTHER CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkacb PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004978 RatGTEx
  ENSRNOG00055023932 RatGTEx
  ENSRNOG00060000873 RatGTEx
  ENSRNOG00065012881 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A4F6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AUN6_RAT UniProtKB/TrEMBL
  A0A8I6AV42 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GBC1 ENTREZGENE, UniProtKB/TrEMBL
  A6HWE9 ENTREZGENE, UniProtKB/TrEMBL
  A6HWF0 ENTREZGENE, UniProtKB/TrEMBL
  A6HWF1 ENTREZGENE, UniProtKB/TrEMBL
  A6HWF2 ENTREZGENE, UniProtKB/TrEMBL
  KAPCB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q05759 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P05206 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Prkacb  protein kinase cAMP-activated catalytic subunit beta  Prkacb  protein kinase, cAMP-dependent, beta catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-30 Prkacb  protein kinase, cAMP-dependent, beta catalytic subunit  Prkacb  protein kinase, cAMP dependent, catalytic, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-08-18 Prkacb  protein kinase, cAMP dependent, catalytic, beta  Prkacb_predicted  protein kinase, cAMP dependent, catalytic, beta (predicted)  gene changed from predicted status to normal gene status 1299863 APPROVED
2005-01-12 Prkacb_predicted  protein kinase, cAMP dependent, catalytic, beta (predicted)      Symbol and Name status set to approved 70820 APPROVED