Gene: Pten (phosphatase and tensin homolog) Rattus norvegicus
Symbol: Pten
Name: phosphatase and tensin homolog
Description: ENCODES a protein that exhibits PDZ domain binding; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; platelet-derived growth factor receptor binding; INVOLVED IN aging; long term synaptic depression; memory; PARTICIPATES IN altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; endometrial cancer pathway; ASSOCIATED WITH Cardiomegaly; Diabetes Mellitus; Diabetic Nephropathies; FOUND IN cytoplasm; dendritic spine; mitochondrion; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; 17beta-estradiol
Type: protein-coding
Also known as: Mmac; MMAC1; mutated in multiple advanced cancers 1; phosphatase and tensin homolog (mutated in multiple advanced cancers 1); phosphatase and tensin homolog deleted on chromosome ten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase and tensin-like protein; TEP1
Latest Assembly: RGSC Genome Assembly v5.0
RGSC Genome Assembly v6.01251,421,814 - 251,487,634+NCBI
Rat Cytogenetic Map1q41-q43 NCBI
RGSC Genome Assembly v5.01258,651,829 - 258,717,009+NCBI
RGSC Genome Assembly v3.41236,771,027 - 236,837,261+NCBI
Rat Celera Assembly1227,746,622 - 227,812,108+NCBI
Genome Assembly 3.11236,935,049 - 237,001,284+NCBI

Launch Genome Browser (GBrowse)     Launch JBrowse

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (RGSC Genome Assembly v5.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pten
Entrez Gene
Ensembl Gene
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 61995
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2015-11-10
Status: ACTIVE