(+)-pilocarpine multiple interactions EXP 6480464 PTEN protein mutant form inhibits the reaction [Pilocarpine results in increased activity of NGFR protein] CTD PMID:21084616 (-)-epigallocatechin 3-gallate decreases expression ISO PTEN (Homo sapiens) 6480464 epigallocatechin gallate results in decreased expression of PTEN mRNA CTD PMID:32512070 (1->4)-beta-D-glucan multiple interactions ISO Pten (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PTEN mRNA CTD PMID:36331819 (R)-noradrenaline multiple interactions EXP 6480464 [Estradiol co-treated with Norepinephrine] results in decreased expression of PTEN mRNA more ... CTD PMID:16954335 (S)-naringenin increases expression ISO PTEN (Homo sapiens) 6480464 naringenin results in increased expression of PTEN mRNA CTD PMID:36235125 (S)-naringenin multiple interactions ISO PTEN (Homo sapiens) 6480464 [naringenin metabolite co-treated with bisphenol A] results in increased expression of PTEN mRNA CTD PMID:36235125 (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of PTEN mRNA CTD PMID:11478936 1,2-dimethylhydrazine decreases expression ISO Pten (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of PTEN mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO Pten (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PTEN mRNA CTD PMID:22206623 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression ISO Pten (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:31907031 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions ISO Pten (Mus musculus) 6480464 [15-deoxy-delta(12 and 14)-prostaglandin J2 co-treated with alitretinoin] results in increased expression of PTEN protein CTD PMID:16611854 17alpha-ethynylestradiol multiple interactions ISO Pten (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PTEN mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of PTEN mRNA CTD PMID:29097150 17alpha-ethynylestradiol affects expression ISO PTEN (Homo sapiens) 6480464 Ethinyl Estradiol affects the expression of PTEN mRNA CTD PMID:20170705 and PMID:26865667 17beta-estradiol decreases expression ISO PTEN (Homo sapiens) 6480464 Estradiol results in decreased expression of PTEN mRNA CTD PMID:21890461 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of PTEN mRNA CTD PMID:16954335 and PMID:32145629 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with Norepinephrine] results in decreased expression of PTEN mRNA CTD PMID:16954335 17beta-estradiol increases expression ISO PTEN (Homo sapiens) 6480464 Estradiol results in increased expression of PTEN mRNA and Estradiol results in increased expression of PTEN protein CTD PMID:19264808 more ... 17beta-estradiol multiple interactions ISO PTEN (Homo sapiens) 6480464 [ESR2 protein results in increased susceptibility to Estradiol] which results in increased expression of PTEN protein more ... CTD PMID:19264808 more ... 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one decreases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in decreased susceptibility to Metribolone CTD PMID:16637073 1H-pyrazole decreases expression ISO Pten (Mus musculus) 6480464 pyrazole results in decreased expression of PTEN mRNA CTD PMID:17945193 2,2',4,4',5,5'-hexachlorobiphenyl decreases expression EXP 6480464 2 more ... CTD PMID:24726520 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Pten (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO PTEN (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of PTEN mRNA CTD PMID:17101203 2,3,7,8-tetrachlorodibenzodioxine decreases phosphorylation ISO PTEN (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased phosphorylation of PTEN protein CTD PMID:27312872 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Pten (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of PTEN mRNA CTD PMID:21570461 and PMID:36222588 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PTEN mRNA CTD PMID:18796159 and PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Pten (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:17942748 more ... 2,3-bis(4-hydroxyphenyl)propionitrile increases expression ISO PTEN (Homo sapiens) 6480464 2 and 3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PTEN protein CTD PMID:19264808 2,3-bis(4-hydroxyphenyl)propionitrile multiple interactions ISO PTEN (Homo sapiens) 6480464 ESR1 protein affects the reaction [2 and 3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of PTEN protein] CTD PMID:19264808 2-acetamidofluorene decreases expression EXP 6480464 2-Acetylaminofluorene results in decreased expression of PTEN protein CTD PMID:19167416 2-butoxyethanol decreases expression ISO Pten (Mus musculus) 6480464 n-butoxyethanol results in decreased expression of PTEN mRNA CTD PMID:19812364 2-methylcholine affects expression ISO PTEN (Homo sapiens) 6480464 beta-methylcholine affects the expression of PTEN mRNA CTD PMID:21179406 2-tert-butylhydroquinone multiple interactions ISO PTEN (Homo sapiens) 6480464 PTEN protein affects the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA] CTD PMID:23829535 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions EXP 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA] CTD PMID:20578043 3,3',5,5'-tetrabromobisphenol A decreases expression EXP 6480464 tetrabromobisphenol A results in decreased expression of PTEN mRNA CTD PMID:28970181 3,4-methylenedioxymethamphetamine increases expression ISO Pten (Mus musculus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PTEN mRNA CTD PMID:20188158 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of PTEN mRNA CTD PMID:34461274 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO PTEN (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PTEN mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PTEN mRNA CTD PMID:28628672 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1 and 2-dithiol-3-thione results in decreased expression of PTEN mRNA CTD PMID:19162173 4-hydroxyphenyl retinamide decreases expression ISO Pten (Mus musculus) 6480464 Fenretinide results in decreased expression of PTEN mRNA CTD PMID:28973697 4-nitrophenol decreases expression ISO Pten (Mus musculus) 6480464 4-nitrophenol results in decreased expression of PTEN mRNA CTD PMID:34673133 4-nonylphenol decreases phosphorylation EXP 6480464 4-nonylphenol results in decreased phosphorylation of PTEN protein CTD PMID:30228064 4-nonylphenol multiple interactions EXP 6480464 4-nonylphenol promotes the reaction [bisphenol A results in decreased phosphorylation of PTEN protein] and bisphenol A inhibits the reaction [4-nonylphenol results in decreased phosphorylation of PTEN protein] CTD PMID:30228064 4-nonylphenol increases expression EXP 6480464 4-nonylphenol results in increased expression of PTEN mRNA CTD PMID:30228064 5-aza-2'-deoxycytidine decreases methylation ISO PTEN (Homo sapiens) 6480464 Decitabine results in decreased methylation of PTEN gene and Decitabine results in decreased methylation of PTEN promoter CTD PMID:21170675 and PMID:21801466 5-aza-2'-deoxycytidine multiple interactions ISO PTEN (Homo sapiens) 6480464 [Decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of PTEN mRNA more ... CTD PMID:18622747 more ... 5-aza-2'-deoxycytidine increases expression ISO PTEN (Homo sapiens) 6480464 Decitabine results in increased expression of PTEN mRNA CTD PMID:21170675 and PMID:21801466 5-azacytidine multiple interactions ISO PTEN (Homo sapiens) 6480464 Azacitidine inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA] more ... CTD PMID:22841775 5-fluorouracil decreases expression ISO PTEN (Homo sapiens) 6480464 Fluorouracil results in decreased expression of PTEN mRNA CTD PMID:17039268 5-fluorouracil increases expression ISO PTEN (Homo sapiens) 6480464 Fluorouracil results in increased expression of PTEN mRNA CTD PMID:24737281 5-methoxypsoralen multiple interactions ISO PTEN (Homo sapiens) 6480464 pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of PTEN protein] CTD PMID:30576070 5-methoxypsoralen increases expression ISO PTEN (Homo sapiens) 6480464 5-Methoxypsoralen results in increased expression of PTEN protein CTD PMID:30576070 9-cis-retinoic acid multiple interactions ISO Pten (Mus musculus) 6480464 [15-deoxy-delta(12 and 14)-prostaglandin J2 co-treated with Alitretinoin] results in increased expression of PTEN protein CTD PMID:16611854 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of PTEN mRNA CTD PMID:28959563 aflatoxin B1 decreases methylation ISO PTEN (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of PTEN gene CTD PMID:27153756 AICA ribonucleotide increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in increased susceptibility to AICA ribonucleotide CTD PMID:19625624 all-trans-retinoic acid multiple interactions ISO PTEN (Homo sapiens) 6480464 [Tretinoin co-treated with IFNG protein] results in increased expression of PTEN protein more ... CTD PMID:17960384 and PMID:21801466 all-trans-retinoic acid decreases methylation ISO PTEN (Homo sapiens) 6480464 Tretinoin results in decreased methylation of PTEN promoter CTD PMID:21801466 all-trans-retinoic acid increases expression ISO PTEN (Homo sapiens) 6480464 Tretinoin results in increased expression of PTEN mRNA CTD PMID:23724009 and PMID:33167477 allyl isothiocyanate multiple interactions ISO PTEN (Homo sapiens) 6480464 allyl isothiocyanate results in increased expression of and results in increased phosphorylation of PTEN protein CTD PMID:37318315 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PTEN mRNA CTD PMID:16483693 ammonium chloride increases expression ISO Pten (Mus musculus) 6480464 Ammonium Chloride results in increased expression of PTEN mRNA CTD PMID:31310755 ammonium chloride decreases expression EXP 6480464 Ammonium Chloride results in decreased expression of PTEN protein CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO PTEN (Homo sapiens) 6480464 pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased expression of PTEN protein] CTD PMID:20534739 antimycin A increases expression ISO PTEN (Homo sapiens) 6480464 Antimycin A results in increased expression of PTEN mRNA CTD PMID:35430258 antimycin A multiple interactions ISO PTEN (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of PTEN mRNA] CTD PMID:35430258 antirheumatic drug increases expression ISO PTEN (Homo sapiens) 6480464 Antirheumatic Agents results in increased expression of PTEN mRNA CTD PMID:24449571 aristolochic acid A decreases expression ISO PTEN (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of PTEN mRNA CTD PMID:33212167 arsane decreases expression ISO PTEN (Homo sapiens) 6480464 Arsenic results in decreased expression of PTEN protein CTD PMID:25586904 arsenic atom decreases expression ISO PTEN (Homo sapiens) 6480464 Arsenic results in decreased expression of PTEN protein CTD PMID:25586904 arsenite(3-) decreases expression ISO PTEN (Homo sapiens) 6480464 arsenite results in decreased expression of PTEN protein CTD PMID:22387281 arsenite(3-) multiple interactions ISO PTEN (Homo sapiens) 6480464 RELA mutant form inhibits the reaction [arsenite results in decreased expression of PTEN protein] CTD PMID:22387281 arsenous acid increases expression ISO PTEN (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of PTEN mRNA and Arsenic Trioxide results in increased expression of PTEN protein CTD PMID:20534739 more ... arsenous acid multiple interactions ISO PTEN (Homo sapiens) 6480464 MAPK8 protein affects the reaction [Arsenic Trioxide results in increased expression of PTEN protein] more ... CTD PMID:20534739 more ... arsenous acid decreases expression ISO PTEN (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of PTEN mRNA CTD PMID:23497375 arsenous acid increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in increased susceptibility to Arsenic Trioxide CTD PMID:22185283 astaxanthin multiple interactions ISO PTEN (Homo sapiens) 6480464 astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of PTEN mRNA] CTD PMID:33212048 atorvastatin calcium increases expression EXP 6480464 Atorvastatin results in increased expression of PTEN protein CTD PMID:15837263 benomyl increases expression EXP 6480464 Benomyl results in increased expression of PTEN mRNA CTD PMID:33930522 benzene multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PTEN mRNA CTD PMID:17905399 benzo[a]pyrene multiple interactions ISO Pten (Mus musculus) 6480464 Benzo(a)pyrene inhibits the reaction [AHR protein binds to PTEN promoter] and thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of PTEN protein] CTD PMID:19654925 and PMID:36193556 benzo[a]pyrene decreases expression ISO Pten (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of PTEN protein CTD PMID:36193556 benzo[a]pyrene increases expression ISO PTEN (Homo sapiens) 6480464 Benzo(a)pyrene metabolite results in increased expression of PTEN mRNA CTD PMID:26314263 benzo[a]pyrene increases expression ISO Pten (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of PTEN mRNA CTD PMID:20504355 benzo[a]pyrene diol epoxide I decreases expression ISO PTEN (Homo sapiens) 6480464 7 more ... CTD PMID:19150397 and PMID:20018196 Benzo[ghi]perylene decreases expression ISO Pten (Mus musculus) 6480464 1 and 12-benzoperylene results in decreased expression of PTEN mRNA CTD PMID:26377693 berberine increases expression ISO Pten (Mus musculus) 6480464 Berberine results in increased expression of PTEN protein CTD PMID:29408570 berberine multiple interactions ISO Pten (Mus musculus) 6480464 ((3Z)-N-(3-chlorophenyl)-3-((3 more ... CTD PMID:29408570 bicalutamide increases activity ISO PTEN (Homo sapiens) 6480464 bicalutamide results in increased activity of PTEN protein CTD PMID:16637073 bicalutamide multiple interactions ISO PTEN (Homo sapiens) 6480464 bicalutamide promotes the reaction [PTEN protein results in decreased expression of KLK3 mRNA] CTD PMID:16637073 bilirubin IXalpha multiple interactions ISO PTEN (Homo sapiens) 6480464 Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 biliverdin multiple interactions ISO PTEN (Homo sapiens) 6480464 Biliverdine inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 bis(2-ethylhexyl) phthalate decreases expression ISO Pten (Mus musculus) 6480464 Diethylhexyl Phthalate results in decreased expression of PTEN mRNA and Diethylhexyl Phthalate results in decreased expression of PTEN protein CTD PMID:24804967 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased expression of PTEN protein and [Plant Extracts co-treated with Diethylhexyl Phthalate] results in decreased expression of PTEN mRNA CTD PMID:29777495 and PMID:34910997 bis(2-ethylhexyl) phthalate affects expression EXP 6480464 Diethylhexyl Phthalate affects the expression of PTEN mRNA CTD PMID:29777495 bis(2-ethylhexyl) phthalate affects expression ISO Pten (Mus musculus) 6480464 Diethylhexyl Phthalate affects the expression of PTEN mRNA CTD PMID:31211961 bis(2-ethylhexyl) phthalate increases expression ISO PTEN (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of PTEN protein CTD PMID:31163220 bis(2-ethylhexyl) phthalate multiple interactions ISO PTEN (Homo sapiens) 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTEN protein] CTD PMID:31163220 bis(2-ethylhexyl) phthalate multiple interactions ISO Pten (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A increases phosphorylation ISO PTEN (Homo sapiens) 6480464 bisphenol A results in increased phosphorylation of PTEN protein CTD PMID:21890461 bisphenol A decreases expression ISO Pten (Mus musculus) 6480464 bisphenol A results in decreased expression of PTEN mRNA CTD PMID:33221593 bisphenol A multiple interactions EXP 6480464 4-nonylphenol promotes the reaction [bisphenol A results in decreased phosphorylation of PTEN protein] more ... CTD PMID:29777495 more ... bisphenol A decreases phosphorylation EXP 6480464 bisphenol A results in decreased phosphorylation of PTEN protein CTD PMID:30228064 bisphenol A multiple interactions ISO Pten (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of PTEN protein CTD PMID:27296223 bisphenol A multiple interactions ISO PTEN (Homo sapiens) 6480464 [bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of PTEN mRNA more ... CTD PMID:24831732 more ... bisphenol A increases expression ISO PTEN (Homo sapiens) 6480464 bisphenol A results in increased expression of PTEN protein CTD PMID:24831732 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PTEN mRNA and bisphenol A results in decreased expression of PTEN protein CTD PMID:24884420 more ... bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PTEN mRNA and bisphenol A results in increased expression of PTEN protein CTD PMID:24464975 more ... bisphenol A affects expression ISO PTEN (Homo sapiens) 6480464 bisphenol A affects the expression of PTEN mRNA CTD PMID:20170705 bisphenol A decreases expression ISO PTEN (Homo sapiens) 6480464 bisphenol A results in decreased expression of PTEN mRNA and bisphenol A results in decreased expression of PTEN protein CTD PMID:21890461 more ... Bisphenol A diglycidyl ether multiple interactions ISO PTEN (Homo sapiens) 6480464 2 more ... CTD PMID:16806087 and PMID:21769449 Bisphenol B decreases expression ISO PTEN (Homo sapiens) 6480464 bisphenol B results in decreased expression of PTEN mRNA CTD PMID:32387340 bisphenol F multiple interactions ISO PTEN (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PTEN mRNA CTD PMID:28628672 bleomycin A2 multiple interactions ISO Pten (Mus musculus) 6480464 ((3Z)-N-(3-chlorophenyl)-3-((3 more ... CTD PMID:29408570 bleomycin A2 decreases expression ISO Pten (Mus musculus) 6480464 Bleomycin results in decreased expression of PTEN mRNA and Bleomycin results in decreased expression of PTEN protein CTD PMID:29408570 Butylbenzyl phthalate decreases expression ISO PTEN (Homo sapiens) 6480464 butylbenzyl phthalate results in decreased expression of PTEN mRNA and butylbenzyl phthalate results in decreased expression of PTEN protein CTD PMID:29864457 Butylbenzyl phthalate multiple interactions ISO PTEN (Homo sapiens) 6480464 MIR19A mRNA affects the reaction [butylbenzyl phthalate results in decreased expression of PTEN protein] and MIR19B1 mRNA affects the reaction [butylbenzyl phthalate results in decreased expression of PTEN protein] CTD PMID:29864457 cadmium atom multiple interactions ISO Pten (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Cadmium results in increased degradation of and results in decreased expression of PTEN protein] more ... CTD PMID:24449419 cadmium dichloride affects expression ISO Pten (Mus musculus) 6480464 Cadmium Chloride affects the expression of PTEN mRNA CTD PMID:18974090 cadmium dichloride increases phosphorylation ISO PTEN (Homo sapiens) 6480464 Cadmium Chloride results in increased phosphorylation of PTEN protein CTD PMID:34905088 cadmium dichloride decreases expression ISO PTEN (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of PTEN mRNA and Cadmium Chloride results in decreased expression of PTEN protein CTD PMID:21195169 more ... cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of PTEN protein CTD PMID:21195169 and PMID:24111524 cadmium dichloride multiple interactions ISO Pten (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein] more ... CTD PMID:24449419 cadmium dichloride multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein] more ... CTD PMID:21195169 and PMID:24111524 cadmium dichloride decreases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN results in decreased susceptibility to Cadmium Chloride CTD PMID:21883094 cadmium dichloride multiple interactions ISO PTEN (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein] more ... CTD PMID:21195169 calciol increases expression ISO Pten (Mus musculus) 6480464 Cholecalciferol results in increased expression of PTEN mRNA CTD PMID:16508948 calciol increases expression ISO PTEN (Homo sapiens) 6480464 Cholecalciferol results in increased expression of PTEN mRNA CTD PMID:21801466 calciol decreases methylation ISO PTEN (Homo sapiens) 6480464 Cholecalciferol results in decreased methylation of PTEN promoter CTD PMID:21801466 calciol multiple interactions ISO PTEN (Homo sapiens) 6480464 Cholecalciferol promotes the reaction [Cladribine results in increased expression of PTEN mRNA] more ... CTD PMID:21801466 camptothecin multiple interactions ISO PTEN (Homo sapiens) 6480464 Camptothecin results in decreased expression of and results in decreased phosphorylation of PTEN protein CTD PMID:30885713 cannabidiol multiple interactions ISO PTEN (Homo sapiens) 6480464 [Cannabidiol co-treated with moringin] results in decreased expression of PTEN mRNA CTD PMID:30096889 cannabidiol increases expression ISO PTEN (Homo sapiens) 6480464 Cannabidiol results in increased expression of PTEN mRNA and Cannabidiol results in increased expression of PTEN protein CTD PMID:30713602 cantharidin increases expression ISO PTEN (Homo sapiens) 6480464 Cantharidin results in increased expression of PTEN mRNA and Cantharidin results in increased expression of PTEN protein CTD PMID:31945315 carbamazepine affects expression ISO PTEN (Homo sapiens) 6480464 Carbamazepine affects the expression of PTEN mRNA CTD PMID:24752500 carbon monoxide multiple interactions ISO PTEN (Homo sapiens) 6480464 Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 carbon nanotube decreases expression ISO Pten (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 and PMID:25620056 carnosic acid multiple interactions ISO PTEN (Homo sapiens) 6480464 salvin promotes the reaction [arsenic trioxide results in increased expression of PTEN mRNA] CTD PMID:23239002 carnosic acid increases expression ISO PTEN (Homo sapiens) 6480464 salvin results in increased expression of PTEN mRNA CTD PMID:23239002 celastrol multiple interactions EXP 6480464 celastrol inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein] more ... CTD PMID:24111524 chloroquine increases expression ISO Pten (Mus musculus) 6480464 Chloroquine results in increased expression of PTEN mRNA CTD PMID:31310755 chlorpyrifos decreases expression ISO Pten (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of PTEN mRNA CTD PMID:29156651 choline multiple interactions ISO Pten (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTEN gene CTD PMID:20938992 ciglitazone increases expression EXP 6480464 ciglitazone results in increased expression of PTEN protein CTD PMID:20578043 ciguatoxin CTX1B affects expression ISO Pten (Mus musculus) 6480464 Ciguatoxins affects the expression of PTEN mRNA CTD PMID:18353800 cilostazol multiple interactions ISO PTEN (Homo sapiens) 6480464 Cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein] more ... CTD PMID:12807996 cilostazol decreases phosphorylation EXP 6480464 cilostazol results in decreased phosphorylation of PTEN protein CTD PMID:15978173 cisplatin increases activity ISO PTEN (Homo sapiens) 6480464 Cisplatin results in increased activity of PTEN protein CTD PMID:11707646 cisplatin multiple interactions ISO Pten (Mus musculus) 6480464 Rutin inhibits the reaction [Cisplatin results in increased phosphorylation of PTEN protein] CTD PMID:33031932 cisplatin increases phosphorylation ISO Pten (Mus musculus) 6480464 Cisplatin results in increased phosphorylation of PTEN protein CTD PMID:33031932 cisplatin multiple interactions ISO PTEN (Homo sapiens) 6480464 [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of PTEN mRNA more ... CTD PMID:23466500 more ... cisplatin increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN results in increased susceptibility to Cisplatin CTD PMID:21116717 cladribine increases expression ISO PTEN (Homo sapiens) 6480464 Cladribine results in increased expression of PTEN mRNA CTD PMID:21801466 cladribine multiple interactions ISO PTEN (Homo sapiens) 6480464 Cholecalciferol promotes the reaction [Cladribine results in increased expression of PTEN mRNA] more ... CTD PMID:21801466 cladribine decreases methylation ISO PTEN (Homo sapiens) 6480464 Cladribine results in decreased methylation of PTEN promoter CTD PMID:21801466 clodronic acid multiple interactions ISO Pten (Mus musculus) 6480464 Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of CD68 mRNA] more ... CTD PMID:27022031 cobalt dichloride multiple interactions ISO PTEN (Homo sapiens) 6480464 PTEN protein inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein] more ... CTD PMID:19808899 cobalt dichloride increases expression ISO PTEN (Homo sapiens) 6480464 cobaltous chloride results in increased expression of PTEN mRNA CTD PMID:19376846 and PMID:26314263 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of PTEN mRNA CTD PMID:24386269 cocaine affects expression ISO Pten (Mus musculus) 6480464 Cocaine affects the expression of PTEN mRNA CTD PMID:15681117 copper atom multiple interactions ISO PTEN (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of PTEN mRNA and [Copper co-treated with Disulfiram] results in decreased expression of PTEN protein CTD PMID:20424113 and PMID:30911355 copper(0) multiple interactions ISO PTEN (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of PTEN mRNA and [Copper co-treated with Disulfiram] results in decreased expression of PTEN protein CTD PMID:20424113 and PMID:30911355 copper(II) sulfate decreases expression ISO PTEN (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of PTEN mRNA CTD PMID:19549813 corticosterone increases phosphorylation ISO Pten (Mus musculus) 6480464 Corticosterone results in increased phosphorylation of PTEN protein CTD PMID:21647420 coumestrol decreases expression ISO PTEN (Homo sapiens) 6480464 Coumestrol results in decreased expression of PTEN mRNA CTD PMID:19167446 crocidolite asbestos decreases expression ISO PTEN (Homo sapiens) 6480464 Asbestos and Crocidolite results in decreased expression of PTEN protein CTD PMID:21570478 cucurbitacin E multiple interactions ISO PTEN (Homo sapiens) 6480464 cucurbitacin E results in increased expression of and results in increased phosphorylation of PTEN protein CTD PMID:27106530 curcumin multiple interactions ISO PTEN (Homo sapiens) 6480464 Curcumin inhibits the reaction [bisphenol A results in increased expression of PTEN protein] CTD PMID:24831732 cycloheximide multiple interactions ISO PTEN (Homo sapiens) 6480464 Cycloheximide affects the reaction [sodium arsenite affects the expression of PTEN protein] more ... CTD PMID:16425225 and PMID:33256086 cytarabine increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in increased susceptibility to Cytarabine CTD PMID:22185283 D-glucitol affects localization ISO Pten (Mus musculus) 6480464 Sorbitol affects the localization of PTEN protein CTD PMID:16807353 D-glucitol affects localization ISO PTEN (Homo sapiens) 6480464 Sorbitol affects the localization of PTEN protein CTD PMID:16807353 D-glucitol affects localization EXP 6480464 Sorbitol affects the localization of PTEN protein CTD PMID:16807353 dactolisib increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN gene mutant form results in increased susceptibility to dactolisib CTD PMID:21372221 daunorubicin increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN results in increased susceptibility to Daunorubicin CTD PMID:21187093 deoxynivalenol increases expression ISO PTEN (Homo sapiens) 6480464 deoxynivalenol results in increased expression of PTEN mRNA CTD PMID:22846391 dexamethasone multiple interactions ISO PTEN (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PTEN mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PTEN mRNA CTD PMID:28628672 dexamethasone multiple interactions ISO Pten (Mus musculus) 6480464 Dexamethasone inhibits the reaction [OVAL protein results in decreased expression of PTEN mRNA] and Dexamethasone inhibits the reaction [OVAL protein results in decreased expression of PTEN protein] CTD PMID:25739523 dextran sulfate multiple interactions ISO Pten (Mus musculus) 6480464 [APC protein affects the susceptibility to Dextran Sulfate] which results in increased chemical synthesis of PTEN protein modified form and resorcinol inhibits the reaction [[APC protein affects the susceptibility to Dextran Sulfate] which results in increased chemical synthesis of PTEN protein modified form] CTD PMID:26262998 diarsenic trioxide decreases expression ISO PTEN (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of PTEN mRNA CTD PMID:23497375 diarsenic trioxide increases expression ISO PTEN (Homo sapiens) 6480464 Arsenic Trioxide results in increased expression of PTEN mRNA and Arsenic Trioxide results in increased expression of PTEN protein CTD PMID:20534739 more ... diarsenic trioxide increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in increased susceptibility to Arsenic Trioxide CTD PMID:22185283 diarsenic trioxide multiple interactions ISO PTEN (Homo sapiens) 6480464 MAPK8 protein affects the reaction [Arsenic Trioxide results in increased expression of PTEN protein] more ... CTD PMID:20534739 more ... diazinon increases methylation ISO PTEN (Homo sapiens) 6480464 Diazinon results in increased methylation of PTEN gene CTD PMID:22964155 diazinon decreases expression EXP 6480464 Diazinon results in decreased expression of PTEN mRNA CTD PMID:35403302 diazinon increases expression EXP 6480464 Diazinon results in increased expression of PTEN mRNA CTD PMID:30359674 diazinon multiple interactions EXP 6480464 Dietary Fats promotes the reaction [Diazinon results in increased expression of PTEN mRNA] CTD PMID:30359674 diazinon affects expression EXP 6480464 Diazinon affects the expression of PTEN mRNA CTD PMID:22546817 dibenzo[a,l]pyrene increases methylation ISO Pten (Mus musculus) 6480464 dibenzo(a and l)pyrene results in increased methylation of PTEN promoter CTD PMID:28476633 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of PTEN mRNA CTD PMID:21266533 dibutyl phthalate increases expression ISO Pten (Mus musculus) 6480464 Dibutyl Phthalate results in increased expression of PTEN protein CTD PMID:33331133 dibutyl phthalate multiple interactions ISO Pten (Mus musculus) 6480464 ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in increased expression of PTEN protein] CTD PMID:33331133 diclofenac affects expression ISO PTEN (Homo sapiens) 6480464 Diclofenac affects the expression of PTEN mRNA CTD PMID:24752500 diclofenac increases expression ISO Pten (Mus musculus) 6480464 Diclofenac results in increased expression of PTEN mRNA CTD PMID:26934552 dicrotophos decreases expression ISO PTEN (Homo sapiens) 6480464 dicrotophos results in decreased expression of PTEN mRNA CTD PMID:28302478 dieldrin increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN gene mutant form results in increased susceptibility to Dieldrin CTD PMID:32421776 diethylstilbestrol decreases expression ISO Pten (Mus musculus) 6480464 Diethylstilbestrol results in decreased expression of PTEN mRNA CTD PMID:16804899 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of PTEN mRNA CTD PMID:37077353 digitoxin increases expression ISO PTEN (Homo sapiens) 6480464 Digitoxin results in increased expression of PTEN protein CTD PMID:34717917 dioxygen decreases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in decreased susceptibility to Oxygen deficiency CTD PMID:21994956 dioxygen multiple interactions ISO PTEN (Homo sapiens) 6480464 PTEN protein inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 protein]] more ... CTD PMID:19808899 dioxygen multiple interactions ISO Pten (Mus musculus) 6480464 rosiglitazone inhibits the reaction [Oxygen deficiency results in decreased expression of PTEN protein] CTD PMID:19520921 dioxygen decreases expression ISO Pten (Mus musculus) 6480464 Oxygen deficiency results in decreased expression of PTEN protein CTD PMID:19520921 disulfiram multiple interactions ISO PTEN (Homo sapiens) 6480464 [Copper co-treated with Disulfiram] results in decreased expression of PTEN protein CTD PMID:20424113 dorsomorphin multiple interactions ISO PTEN (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:20673057 and PMID:27188386 doxorubicin multiple interactions ISO PTEN (Homo sapiens) 6480464 [Doxorubicin co-treated with resveratrol] results in increased expression of PTEN mRNA more ... CTD PMID:16438844 more ... doxorubicin multiple interactions EXP 6480464 plumbagin inhibits the reaction [Doxorubicin results in decreased phosphorylation of PTEN protein] CTD PMID:32691977 doxorubicin decreases phosphorylation EXP 6480464 Doxorubicin results in decreased phosphorylation of PTEN protein CTD PMID:32691977 doxorubicin affects expression ISO PTEN (Homo sapiens) 6480464 Doxorubicin affects the expression of PTEN mRNA CTD PMID:26969377 doxorubicin increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in increased susceptibility to Doxorubicin and PTEN results in increased susceptibility to Doxorubicin CTD PMID:15548710 more ... doxorubicin increases activity ISO PTEN (Homo sapiens) 6480464 Doxorubicin results in increased activity of PTEN protein CTD PMID:11707646 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of PTEN mRNA CTD PMID:31464424 enzyme inhibitor multiple interactions ISO PTEN (Homo sapiens) 6480464 Enzyme Inhibitors inhibits the reaction [gossypetin results in increased expression of PTEN protein] CTD PMID:25622137 ethanol multiple interactions EXP 6480464 [Ethanol results in decreased susceptibility to INS1 protein] which results in increased activity of PTEN protein more ... CTD PMID:12700235 ethanol affects splicing ISO Pten (Mus musculus) 6480464 Ethanol affects the splicing of PTEN mRNA CTD PMID:30319688 ethyl methanesulfonate increases expression ISO PTEN (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of PTEN mRNA CTD PMID:23649840 etoposide multiple interactions ISO PTEN (Homo sapiens) 6480464 PTEN protein inhibits the reaction [Etoposide results in increased phosphorylation of and results in increased activity of AKT1 protein] more ... CTD PMID:16807353 and PMID:17935137 etoposide increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in increased susceptibility to Etoposide CTD PMID:17935137 fenhexamid decreases expression ISO PTEN (Homo sapiens) 6480464 N-(2 and 3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PTEN mRNA CTD PMID:23052036 ferulic acid multiple interactions EXP 6480464 ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTEN protein] more ... CTD PMID:35110471 flavanone increases expression ISO PTEN (Homo sapiens) 6480464 flavanone results in increased expression of PTEN protein CTD PMID:22056764 fludioxonil decreases expression ISO PTEN (Homo sapiens) 6480464 fludioxonil results in decreased expression of PTEN mRNA CTD PMID:23052036 flutamide increases expression EXP 6480464 Flutamide results in increased expression of PTEN mRNA CTD PMID:24136188 folic acid multiple interactions ISO Pten (Mus musculus) 6480464 [1 more ... CTD PMID:20938992 and PMID:22206623 folic acid increases methylation ISO PTEN (Homo sapiens) 6480464 Folic Acid results in increased methylation of PTEN promoter CTD PMID:23219837 folic acid multiple interactions ISO PTEN (Homo sapiens) 6480464 Folic Acid inhibits the reaction [aluminum maltolate results in increased expression of PTEN protein] more ... CTD PMID:27113042 folic acid decreases expression ISO PTEN (Homo sapiens) 6480464 Folic Acid results in decreased expression of PTEN mRNA CTD PMID:23219837 formaldehyde increases expression ISO PTEN (Homo sapiens) 6480464 Formaldehyde results in increased expression of PTEN mRNA CTD PMID:23649840 fructose multiple interactions EXP 6480464 tributylhexadecylphosphonium bromide inhibits the reaction [Fructose results in increased expression of PTEN protein] CTD PMID:26358169 fructose increases expression EXP 6480464 Fructose results in increased expression of PTEN protein CTD PMID:26358169 fulvestrant increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in increased susceptibility to fulvestrant CTD PMID:19435893 fulvestrant increases methylation ISO PTEN (Homo sapiens) 6480464 Fulvestrant results in increased methylation of PTEN gene CTD PMID:31601247 fulvestrant multiple interactions ISO PTEN (Homo sapiens) 6480464 fulvestrant inhibits the reaction [Quercetin results in increased expression of PTEN protein] CTD PMID:21732360 gallic acid increases secretion ISO PTEN (Homo sapiens) 6480464 Gallic Acid results in increased secretion of PTEN protein CTD PMID:26530725 gefitinib multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Gefitinib results in increased expression of PTEN mRNA] CTD PMID:32370496 gefitinib increases expression EXP 6480464 Gefitinib results in increased expression of PTEN mRNA more ... CTD PMID:32370496 gemcitabine affects expression ISO PTEN (Homo sapiens) 6480464 Gemcitabine affects the expression of PTEN mRNA CTD PMID:17039268 genistein multiple interactions ISO PTEN (Homo sapiens) 6480464 dorsomorphin inhibits the reaction [Genistein results in increased expression of PTEN protein] CTD PMID:20673057 genistein affects expression ISO PTEN (Homo sapiens) 6480464 Genistein affects the expression of PTEN mRNA CTD PMID:26865667 genistein increases expression ISO PTEN (Homo sapiens) 6480464 Genistein results in increased expression of PTEN mRNA and Genistein results in increased expression of PTEN protein CTD PMID:15829497 and PMID:20673057 genistein decreases expression ISO Pten (Mus musculus) 6480464 Genistein results in decreased expression of PTEN mRNA CTD PMID:21048042 genistein increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in increased susceptibility to Genistein CTD PMID:20673057 geraniol multiple interactions EXP 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PTEN protein] CTD PMID:28428697 ginsenoside Rg1 multiple interactions ISO Pten (Mus musculus) 6480464 ginsenoside Rg1 inhibits the reaction [Dibutyl Phthalate results in increased expression of PTEN protein] CTD PMID:33331133 glufosinate affects expression ISO Pten (Mus musculus) 6480464 phosphinothricin affects the expression of PTEN mRNA CTD PMID:25477793 gossypetin increases expression ISO PTEN (Homo sapiens) 6480464 gossypetin results in increased expression of PTEN protein CTD PMID:25622137 gossypetin multiple interactions ISO PTEN (Homo sapiens) 6480464 Enzyme Inhibitors inhibits the reaction [gossypetin results in increased expression of PTEN protein] CTD PMID:25622137 graphene oxide increases expression ISO PTEN (Homo sapiens) 6480464 graphene oxide results in increased expression of PTEN protein CTD PMID:32070776 graphene oxide decreases expression ISO PTEN (Homo sapiens) 6480464 graphene oxide results in decreased expression of PTEN mRNA CTD PMID:32070776 hemin multiple interactions ISO PTEN (Homo sapiens) 6480464 Hemin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 hesperetin multiple interactions EXP 6480464 hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]] more ... CTD PMID:27818223 hexadecanoic acid multiple interactions EXP 6480464 MIR141 mRNA promotes the reaction [Palmitic Acid results in increased expression of PTEN protein] CTD PMID:34897970 hexadecanoic acid increases expression EXP 6480464 Palmitic Acid results in increased expression of PTEN protein CTD PMID:34897970 hydrogen peroxide increases abundance ISO Pten (Mus musculus) 6480464 PTEN gene mutant form results in increased abundance of Hydrogen Peroxide CTD PMID:27022031 hydrogen peroxide increases expression ISO PTEN (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of PTEN mRNA CTD PMID:33212048 hydrogen peroxide multiple interactions ISO PTEN (Homo sapiens) 6480464 astaxanthine inhibits the reaction [Hydrogen Peroxide results in increased expression of PTEN mRNA] and Hydrogen Peroxide results in increased oxidation of and results in decreased activity of PTEN protein CTD PMID:11916965 and PMID:33212048 hydrogen peroxide decreases expression ISO Pten (Mus musculus) 6480464 Hydrogen Peroxide results in decreased expression of PTEN protein CTD PMID:27494022 hydrogen peroxide multiple interactions ISO Pten (Mus musculus) 6480464 PI103 inhibits the reaction [Hydrogen Peroxide results in decreased expression of PTEN protein] and Quercetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PTEN protein] CTD PMID:27494022 hydroxyflutamide increases phosphorylation EXP 6480464 hydroxyflutamide results in increased phosphorylation of PTEN protein CTD PMID:26437446 hydroxyflutamide multiple interactions EXP 6480464 hydroxyflutamide promotes the reaction [Testosterone results in increased phosphorylation of PTEN protein] CTD PMID:26437446 indometacin multiple interactions ISO PTEN (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PTEN mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PTEN mRNA CTD PMID:28628672 isoprenaline increases expression ISO Pten (Mus musculus) 6480464 Isoproterenol results in increased expression of PTEN mRNA CTD PMID:20003209 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of PTEN mRNA and Isoproterenol results in increased expression of PTEN protein CTD PMID:16188065 ketoconazole decreases expression EXP 6480464 Ketoconazole results in decreased expression of PTEN mRNA CTD PMID:37077353 L-methionine multiple interactions ISO Pten (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTEN gene CTD PMID:20938992 lead(0) affects expression ISO PTEN (Homo sapiens) 6480464 Lead affects the expression of PTEN mRNA CTD PMID:28903495 leflunomide increases expression ISO PTEN (Homo sapiens) 6480464 leflunomide results in increased expression of PTEN mRNA CTD PMID:28988120 linsidomine increases oxidation EXP 6480464 linsidomine results in increased oxidation of PTEN protein CTD PMID:17302912 lipopolysaccharide multiple interactions ISO Pten (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [PTEN gene mutant form results in increased secretion of GPT protein]] more ... CTD PMID:27022031 lipopolysaccharide increases expression ISO PTEN (Homo sapiens) 6480464 Lipopolysaccharides results in increased expression of PTEN mRNA CTD PMID:35953652 lipopolysaccharide multiple interactions EXP 6480464 ferulic acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTEN protein] more ... CTD PMID:35110471 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of PTEN protein CTD PMID:35110471 lipopolysaccharide increases abundance ISO Pten (Mus musculus) 6480464 PTEN gene mutant form results in increased abundance of Lipopolysaccharides CTD PMID:27022031 lovastatin multiple interactions ISO PTEN (Homo sapiens) 6480464 Cycloheximide inhibits the reaction [Lovastatin results in increased expression of PTEN protein] and PPARG protein affects the reaction [Lovastatin results in increased expression of PTEN protein] CTD PMID:16425225 lovastatin multiple interactions EXP 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA] more ... CTD PMID:20578043 lovastatin increases expression EXP 6480464 Lovastatin results in increased expression of PTEN mRNA CTD PMID:20578043 lovastatin increases expression ISO Pten (Mus musculus) 6480464 Lovastatin results in increased expression of PTEN protein CTD PMID:16425225 lovastatin multiple interactions ISO Pten (Mus musculus) 6480464 PPARG affects the reaction [Lovastatin results in increased expression of PTEN protein] CTD PMID:16425225 lovastatin increases expression ISO PTEN (Homo sapiens) 6480464 Lovastatin results in increased expression of PTEN protein CTD PMID:16425225 lupeol increases expression ISO PTEN (Homo sapiens) 6480464 lupeol results in increased expression of PTEN protein CTD PMID:20979057 lupeol increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in increased susceptibility to lupeol CTD PMID:20979057 luteolin multiple interactions EXP 6480464 Luteolin inhibits the reaction [Methamphetamine results in increased expression of PTEN protein] CTD PMID:32035215 LY294002 multiple interactions ISO PTEN (Homo sapiens) 6480464 [decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of PTEN mRNA more ... CTD PMID:18622747 and PMID:19808899 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Gefitinib results in increased expression of PTEN mRNA] CTD PMID:32370496 LY294002 affects response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein affects the susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one CTD PMID:33256086 LY294002 increases expression EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PTEN mRNA CTD PMID:32370496 maculosin multiple interactions ISO Pten (Mus musculus) 6480464 maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein] CTD PMID:34726822 malonaldehyde increases abundance ISO PTEN (Homo sapiens) 6480464 PTEN mutant form results in increased abundance of Malondialdehyde CTD PMID:26548909 mercury dichloride decreases expression ISO PTEN (Homo sapiens) 6480464 Mercuric Chloride results in decreased expression of PTEN mRNA CTD PMID:27188386 metformin multiple interactions EXP 6480464 Metformin inhibits the reaction [Testosterone results in decreased expression of PTEN mRNA] CTD PMID:26492952 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of PTEN mRNA and Methamphetamine results in increased expression of PTEN protein CTD PMID:19564919 and PMID:32035215 methamphetamine multiple interactions EXP 6480464 Luteolin inhibits the reaction [Methamphetamine results in increased expression of PTEN protein] CTD PMID:32035215 methidathion decreases expression ISO Pten (Mus musculus) 6480464 methidathion results in decreased expression of PTEN mRNA CTD PMID:34813904 methotrexate increases expression ISO PTEN (Homo sapiens) 6480464 Methotrexate results in increased expression of PTEN mRNA CTD PMID:17400583 methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of PTEN gene CTD PMID:35440735 methyl methanesulfonate increases expression ISO PTEN (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of PTEN mRNA CTD PMID:23649840 methylarsonic acid decreases expression EXP 6480464 monomethylarsonic acid results in decreased expression of PTEN mRNA CTD PMID:24091636 methylarsonic acid decreases expression ISO PTEN (Homo sapiens) 6480464 monomethylarsonic acid results in decreased expression of PTEN mRNA CTD PMID:24091636 methylmercury chloride decreases expression ISO PTEN (Homo sapiens) 6480464 methylmercuric chloride results in decreased expression of PTEN mRNA CTD PMID:26272509 and PMID:28001369 methylmercury chloride increases expression ISO PTEN (Homo sapiens) 6480464 methylmercuric chloride results in increased expression of PTEN mRNA CTD PMID:28001369 methylmercury chloride decreases expression EXP 6480464 methylmercuric chloride results in decreased expression of PTEN protein modified form CTD PMID:28821999 methylmercury(1+) multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PTEN mRNA CTD PMID:17905399 methylmercury(1+) increases expression ISO PTEN (Homo sapiens) 6480464 methylmercury II results in increased expression of PTEN mRNA CTD PMID:26314263 methylseleninic acid increases expression ISO PTEN (Homo sapiens) 6480464 methylselenic acid results in increased expression of PTEN mRNA CTD PMID:12517777 mevinphos multiple interactions EXP 6480464 Mevinphos results in increased activity of and results in decreased oxidation of PTEN protein more ... CTD PMID:28601397 microcystin-LR decreases expression ISO PTEN (Homo sapiens) 6480464 cyanoginosin LR results in decreased expression of PTEN mRNA and cyanoginosin LR results in decreased expression of PTEN protein CTD PMID:28062358 mono(2-ethylhexyl) phthalate multiple interactions ISO PTEN (Homo sapiens) 6480464 [bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of PTEN mRNA more ... CTD PMID:34910997 morin multiple interactions EXP 6480464 morin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein modified form] CTD PMID:19931519 N-acetyl-L-cysteine multiple interactions ISO Pten (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein] more ... CTD PMID:24449419 and PMID:27022031 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein] CTD PMID:21195169 N-acetyl-L-cysteine multiple interactions ISO PTEN (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of PTEN mRNA] and Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein] CTD PMID:21195169 and PMID:35430258 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zinc Sulfate results in decreased stability of PTEN protein] CTD PMID:20100827 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression ISO PTEN (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PTEN protein CTD PMID:33256086 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO Pten (Mus musculus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein] and benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium results in increased degradation of and results in decreased expression of PTEN protein] CTD PMID:24449419 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases ubiquitination ISO PTEN (Homo sapiens) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of PTEN protein and benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of PTEN protein modified form CTD PMID:17684018 N-ethyl-N-nitrosourea increases mutagenesis ISO Pten (Mus musculus) 6480464 Ethylnitrosourea results in increased mutagenesis of PTEN gene CTD PMID:15755804 and PMID:16724327 N-ethyl-N-nitrosourea decreases expression ISO Pten (Mus musculus) 6480464 Ethylnitrosourea results in decreased expression of PTEN protein CTD PMID:32902906 N-methyl-4-phenylpyridinium increases expression ISO PTEN (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in increased expression of PTEN protein CTD PMID:31907031 and PMID:35279586 N-methyl-4-phenylpyridinium multiple interactions ISO PTEN (Homo sapiens) 6480464 SOS1-IT1 affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTEN protein] CTD PMID:35279586 N-methyl-N'-nitro-N-nitrosoguanidine decreases response to substance ISO Pten (Mus musculus) 6480464 PTEN protein results in decreased susceptibility to Methylnitronitrosoguanidine CTD PMID:20530668 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP 6480464 geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PTEN protein] CTD PMID:28428697 N-methyl-N'-nitro-N-nitrosoguanidine decreases expression EXP 6480464 Methylnitronitrosoguanidine results in decreased expression of PTEN protein CTD PMID:28428697 N-methyl-N-nitrosourea decreases expression ISO Pten (Mus musculus) 6480464 Methylnitrosourea results in decreased expression of PTEN mRNA CTD PMID:16616109 N-nitrosodiethylamine multiple interactions EXP 6480464 3 more ... CTD PMID:19931519 and PMID:27048571 N-nitrosodiethylamine decreases expression ISO Pten (Mus musculus) 6480464 Diethylnitrosamine results in decreased expression of PTEN protein CTD PMID:34726822 N-nitrosodiethylamine multiple interactions ISO Pten (Mus musculus) 6480464 maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein] and Quercetin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein] CTD PMID:34726822 N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of PTEN protein modified form CTD PMID:19931519 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of PTEN mRNA CTD PMID:24136188 nickel dichloride increases expression ISO PTEN (Homo sapiens) 6480464 nickel chloride results in increased expression of PTEN mRNA CTD PMID:17312168 nickel sulfate increases expression ISO PTEN (Homo sapiens) 6480464 nickel sulfate results in increased expression of PTEN mRNA CTD PMID:16780908 niclosamide increases expression ISO PTEN (Homo sapiens) 6480464 Niclosamide results in increased expression of PTEN mRNA CTD PMID:29843133 nicotine increases expression EXP 6480464 Nicotine results in increased expression of PTEN mRNA CTD PMID:11478936 Nonylphenol increases expression EXP 6480464 nonylphenol results in increased expression of PTEN mRNA CTD PMID:27832966 Nonylphenol multiple interactions EXP 6480464 wortmannin inhibits the reaction [nonylphenol results in decreased expression of PTEN protein] CTD PMID:27832966 Nonylphenol decreases expression EXP 6480464 nonylphenol results in decreased expression of PTEN protein CTD PMID:27832966 ochratoxin A decreases expression ISO PTEN (Homo sapiens) 6480464 ochratoxin A results in decreased expression of PTEN mRNA CTD PMID:19287073 ochratoxin A increases expression ISO PTEN (Homo sapiens) 6480464 ochratoxin A metabolite results in increased expression of PTEN mRNA more ... CTD PMID:26314263 and PMID:34101318 ochratoxin A decreases phosphorylation ISO PTEN (Homo sapiens) 6480464 ochratoxin A results in decreased phosphorylation of PTEN protein CTD PMID:25002221 oleanolic acid increases expression ISO PTEN (Homo sapiens) 6480464 Oleanolic Acid results in increased expression of PTEN protein CTD PMID:20726234 omacetaxine mepesuccinate increases expression ISO PTEN (Homo sapiens) 6480464 Homoharringtonine results in increased expression of PTEN protein CTD PMID:31726078 orlistat increases expression ISO PTEN (Homo sapiens) 6480464 Orlistat results in increased expression of PTEN protein CTD PMID:32045588 orlistat multiple interactions ISO PTEN (Homo sapiens) 6480464 Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein] CTD PMID:32045588 osthole increases expression ISO PTEN (Homo sapiens) 6480464 osthol results in increased expression of PTEN protein CTD PMID:31870840 oxybenzone increases expression ISO PTEN (Homo sapiens) 6480464 oxybenzone results in increased expression of PTEN mRNA CTD PMID:36581016 paclitaxel increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN results in increased susceptibility to Paclitaxel CTD PMID:15548710 paclitaxel increases activity ISO PTEN (Homo sapiens) 6480464 Paclitaxel results in increased activity of PTEN protein CTD PMID:11707646 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of PTEN mRNA CTD PMID:33387578 paracetamol decreases expression ISO Pten (Mus musculus) 6480464 Acetaminophen results in decreased expression of PTEN mRNA and Acetaminophen results in decreased expression of PTEN protein CTD PMID:37179516 paraquat multiple interactions EXP 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosiglitazone inhibits the reaction [Paraquat results in decreased expression of PTEN mRNA]] more ... CTD PMID:30797787 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of PTEN mRNA and Paraquat results in decreased expression of PTEN protein CTD PMID:30797787 paxilline multiple interactions ISO PTEN (Homo sapiens) 6480464 paxilline inhibits the reaction [cilostazol inhibits the reaction [TNF results in increased phosphorylation of PTEN protein]] CTD PMID:12807996 perfluorohexanesulfonic acid increases expression ISO Pten (Mus musculus) 6480464 perfluorohexanesulfonic acid results in increased expression of PTEN mRNA CTD PMID:37995155 perfluorooctane-1-sulfonic acid multiple interactions ISO Pten (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PTEN mRNA CTD PMID:36331819 perfluorooctanoic acid increases expression ISO PTEN (Homo sapiens) 6480464 perfluorooctanoic acid results in increased expression of PTEN mRNA CTD PMID:23978341 perfluorooctanoic acid increases expression ISO Pten (Mus musculus) 6480464 perfluorooctanoic acid results in increased expression of PTEN protein CTD PMID:36214631 and PMID:37422089 perfluorooctanoic acid decreases expression ISO Pten (Mus musculus) 6480464 perfluorooctanoic acid results in decreased expression of PTEN mRNA CTD PMID:32320774 peroxynitrous acid increases oxidation EXP 6480464 Peroxynitrous Acid results in increased oxidation of PTEN protein CTD PMID:17302912 phenobarbital affects expression ISO Pten (Mus musculus) 6480464 Phenobarbital affects the expression of PTEN mRNA CTD PMID:23091169 phenobarbital multiple interactions EXP 6480464 3 more ... CTD PMID:27048571 PhIP decreases expression ISO Pten (Mus musculus) 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in decreased expression of PTEN protein CTD PMID:22581815 phosphatidylcholine multiple interactions ISO PTEN (Homo sapiens) 6480464 [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines] CTD PMID:15313215 phosphatidylcholine affects binding ISO PTEN (Homo sapiens) 6480464 PTEN protein binds to Phosphatidylcholines CTD PMID:15313215 phosphatidylethanolamine affects binding ISO PTEN (Homo sapiens) 6480464 PTEN protein binds to phosphatidylethanolamine CTD PMID:15313215 phosphatidylethanolamine multiple interactions ISO PTEN (Homo sapiens) 6480464 [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to phosphatidylethanolamine] CTD PMID:15313215 pioglitazone increases expression ISO PTEN (Homo sapiens) 6480464 Pioglitazone results in increased expression of PTEN mRNA CTD PMID:32589349 pirinixic acid decreases expression ISO Pten (Mus musculus) 6480464 pirinixic acid results in decreased expression of PTEN mRNA CTD PMID:20813756 plumbagin multiple interactions EXP 6480464 plumbagin inhibits the reaction [Doxorubicin results in decreased phosphorylation of PTEN protein] CTD PMID:32691977 potassium iodide decreases expression EXP 6480464 Potassium Iodide results in decreased expression of PTEN mRNA CTD PMID:38013145 procymidone increases expression EXP 6480464 procymidone results in increased expression of PTEN mRNA CTD PMID:15686871 progesterone multiple interactions EXP 6480464 [Progesterone co-treated with Norepinephrine] results in increased expression of PTEN mRNA CTD PMID:16954335 progesterone affects expression ISO Pten (Mus musculus) 6480464 Progesterone affects the expression of PTEN mRNA CTD PMID:17251523 propofol multiple interactions ISO PTEN (Homo sapiens) 6480464 CASC9 protein inhibits the reaction [Propofol results in increased expression of PTEN protein] CTD PMID:35238236 propofol increases expression ISO PTEN (Homo sapiens) 6480464 Propofol results in increased expression of PTEN protein CTD PMID:35238236 quartz decreases expression ISO PTEN (Homo sapiens) 6480464 Quartz results in decreased expression of PTEN protein CTD PMID:35499148 quartz multiple interactions ISO PTEN (Homo sapiens) 6480464 FOSL1 promotes the reaction [Quartz results in decreased expression of PTEN protein] and MIR34C inhibits the reaction [Quartz results in decreased expression of PTEN protein] CTD PMID:35499148 quercetin increases expression EXP 6480464 Quercetin results in increased expression of PTEN mRNA CTD PMID:18095365 quercetin decreases expression ISO PTEN (Homo sapiens) 6480464 Quercetin results in decreased expression of PTEN mRNA CTD PMID:36982678 quercetin multiple interactions ISO PTEN (Homo sapiens) 6480464 [ESR2 protein results in increased susceptibility to Quercetin] which results in increased expression of PTEN protein and fulvestrant inhibits the reaction [Quercetin results in increased expression of PTEN protein] CTD PMID:21732360 quercetin increases expression ISO PTEN (Homo sapiens) 6480464 Quercetin results in increased expression of PTEN mRNA and Quercetin results in increased expression of PTEN protein CTD PMID:14715546 more ... quercetin multiple interactions ISO Pten (Mus musculus) 6480464 Quercetin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein] and Quercetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of PTEN protein] CTD PMID:27494022 and PMID:34726822 reactive oxygen species decreases expression ISO PTEN (Homo sapiens) 6480464 Reactive Oxygen Species results in decreased expression of PTEN mRNA CTD PMID:25800948 resorcinol multiple interactions ISO Pten (Mus musculus) 6480464 resorcinol inhibits the reaction [[APC protein affects the susceptibility to Dextran Sulfate] which results in increased chemical synthesis of PTEN protein modified form] CTD PMID:26262998 resveratrol increases activity ISO PTEN (Homo sapiens) 6480464 resveratrol results in increased activity of PTEN protein CTD PMID:24812624 resveratrol multiple interactions ISO Pten (Mus musculus) 6480464 Resveratrol inhibits the reaction [OVAL protein results in decreased expression of PTEN mRNA] and Resveratrol inhibits the reaction [OVAL protein results in decreased expression of PTEN protein] CTD PMID:25739523 resveratrol decreases methylation ISO PTEN (Homo sapiens) 6480464 resveratrol results in decreased methylation of PTEN promoter CTD PMID:21801466 resveratrol decreases expression ISO PTEN (Homo sapiens) 6480464 resveratrol results in decreased expression of PTEN mRNA CTD PMID:22971900 resveratrol increases expression ISO PTEN (Homo sapiens) 6480464 resveratrol results in increased expression of PTEN mRNA and resveratrol results in increased expression of PTEN protein CTD PMID:15829497 more ... resveratrol decreases phosphorylation ISO PTEN (Homo sapiens) 6480464 resveratrol results in decreased phosphorylation of PTEN protein CTD PMID:26530632 resveratrol increases phosphorylation ISO Pten (Mus musculus) 6480464 resveratrol results in increased phosphorylation of PTEN protein CTD PMID:22363816 resveratrol multiple interactions ISO PTEN (Homo sapiens) 6480464 [Doxorubicin co-treated with resveratrol] results in increased expression of PTEN mRNA more ... CTD PMID:20729295 more ... rimonabant multiple interactions EXP 6480464 [(3R)-((2 more ... CTD PMID:32833042 rimonabant affects expression EXP 6480464 Rimonabant affects the expression of PTEN mRNA CTD PMID:32833042 rivastigmine multiple interactions EXP 6480464 Rivastigmine inhibits the reaction [Streptozocin results in increased expression of PTEN mRNA] CTD PMID:32805344 rotenone decreases expression ISO Pten (Mus musculus) 6480464 Rotenone results in decreased expression of PTEN mRNA CTD PMID:26806867 rutin multiple interactions ISO Pten (Mus musculus) 6480464 Rutin inhibits the reaction [Cisplatin results in increased phosphorylation of PTEN protein] CTD PMID:33031932 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO Pten (Mus musculus) 6480464 Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein] and Buthionine Sulfoximine promotes the reaction [Cadmium results in increased degradation of and results in decreased expression of PTEN protein] CTD PMID:24449419 SB 203580 multiple interactions ISO PTEN (Homo sapiens) 6480464 SB 203580 inhibits the reaction [IL18 protein results in increased expression of PTEN mRNA] CTD PMID:18215737 SB 431542 multiple interactions ISO PTEN (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide affects methylation ISO PTEN (Homo sapiens) 6480464 Silicon Dioxide affects the methylation of PTEN promoter CTD PMID:27621875 simvastatin increases expression ISO Pten (Mus musculus) 6480464 Simvastatin results in increased expression of PTEN mRNA and Simvastatin results in increased expression of PTEN protein CTD PMID:20060890 sirolimus multiple interactions ISO PTEN (Homo sapiens) 6480464 [Decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of PTEN mRNA and Sirolimus inhibits the reaction [TNF protein results in decreased expression of PTEN protein] CTD PMID:18622747 and PMID:31676321 sirolimus multiple interactions EXP 6480464 Sirolimus inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein] CTD PMID:21195169 sirolimus decreases expression ISO Pten (Mus musculus) 6480464 Sirolimus results in decreased expression of PTEN protein CTD PMID:18303120 sirolimus decreases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in decreased susceptibility to Sirolimus CTD PMID:19625624 sodium arsenate increases expression ISO Pten (Mus musculus) 6480464 sodium arsenate results in increased expression of PTEN mRNA CTD PMID:21795629 sodium arsenate decreases expression EXP 6480464 sodium arsenate results in decreased expression of PTEN mRNA and sodium arsenate results in decreased expression of PTEN protein CTD PMID:14713550 sodium arsenite decreases expression ISO PTEN (Homo sapiens) 6480464 sodium arsenite results in decreased expression of PTEN mRNA and sodium arsenite results in decreased expression of PTEN protein CTD PMID:20056578 more ... sodium arsenite affects response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein affects the susceptibility to sodium arsenite CTD PMID:33256086 sodium arsenite affects expression ISO PTEN (Homo sapiens) 6480464 sodium arsenite affects the expression of PTEN protein CTD PMID:33256086 sodium arsenite increases phosphorylation ISO PTEN (Homo sapiens) 6480464 sodium arsenite results in increased phosphorylation of PTEN protein CTD PMID:29039521 sodium arsenite affects methylation ISO PTEN (Homo sapiens) 6480464 sodium arsenite affects the methylation of PTEN gene CTD PMID:28589171 sodium arsenite multiple interactions ISO PTEN (Homo sapiens) 6480464 Cycloheximide affects the reaction [sodium arsenite affects the expression of PTEN protein] more ... CTD PMID:26432159 more ... sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of PTEN mRNA and sodium arsenite results in decreased expression of PTEN protein CTD PMID:26432159 and PMID:35314868 sodium arsenite decreases expression ISO Pten (Mus musculus) 6480464 sodium arsenite results in decreased expression of PTEN mRNA CTD PMID:16014739 sodium fluoride increases expression ISO Pten (Mus musculus) 6480464 Sodium Fluoride results in increased expression of PTEN mRNA CTD PMID:21340527 sodium fluoride multiple interactions ISO PTEN (Homo sapiens) 6480464 MIR21 mRNA affects the reaction [Sodium Fluoride results in decreased expression of PTEN protein] CTD PMID:34942272 sodium fluoride decreases expression ISO PTEN (Homo sapiens) 6480464 Sodium Fluoride results in decreased expression of PTEN protein CTD PMID:34942272 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of PTEN mRNA CTD PMID:32805344 streptozocin multiple interactions EXP 6480464 Phycocyanin inhibits the reaction [Streptozocin results in increased expression of PTEN mRNA] more ... CTD PMID:32805344 sunitinib multiple interactions ISO PTEN (Homo sapiens) 6480464 PTEN protein inhibits the reaction [sunitinib results in increased expression of and results in increased secretion of CXCL8 protein] and PTEN protein inhibits the reaction [sunitinib results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:22532600 sunitinib increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in increased susceptibility to sunitinib CTD PMID:22532600 tamoxifen increases response to substance ISO PTEN (Homo sapiens) 6480464 PTEN protein results in increased susceptibility to Tamoxifen CTD PMID:19435893 tert-butyl hydroperoxide increases expression ISO PTEN (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of PTEN mRNA CTD PMID:15336504 testosterone multiple interactions EXP 6480464 hydroxyflutamide promotes the reaction [Testosterone results in increased phosphorylation of PTEN protein] more ... CTD PMID:16954335 more ... testosterone decreases expression ISO PTEN (Homo sapiens) 6480464 Testosterone results in decreased expression of PTEN mRNA CTD PMID:33359661 testosterone increases phosphorylation EXP 6480464 Testosterone results in increased phosphorylation of PTEN protein CTD PMID:26437446 testosterone decreases expression EXP 6480464 Testosterone results in decreased expression of PTEN mRNA CTD PMID:16954335 and PMID:26492952 Tetrachlorobisphenol A multiple interactions ISO PTEN (Homo sapiens) 6480464 4-(6-bromo-1 more ... CTD PMID:36190352 Tetrachlorobisphenol A decreases expression ISO PTEN (Homo sapiens) 6480464 tetrachlorodian results in decreased expression of PTEN mRNA CTD PMID:36190352 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of PTEN mRNA and Carbon Tetrachloride results in decreased expression of PTEN protein CTD PMID:22841775 and PMID:27818223 tetrachloromethane multiple interactions EXP 6480464 hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN mRNA] and hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN protein] CTD PMID:27818223 tetrachloromethane increases methylation EXP 6480464 Carbon Tetrachloride results in increased methylation of PTEN promoter CTD PMID:22841775 tetracycline increases expression ISO Pten (Mus musculus) 6480464 Tetracycline results in increased expression of PTEN mRNA CTD PMID:16917069 thalidomide increases expression ISO PTEN (Homo sapiens) 6480464 Thalidomide results in increased expression of PTEN protein CTD PMID:19567134 thymoquinone multiple interactions ISO Pten (Mus musculus) 6480464 thymoquinone inhibits the reaction [Benzo(a)pyrene results in decreased expression of PTEN protein] CTD PMID:36193556 titanium dioxide decreases expression ISO Pten (Mus musculus) 6480464 titanium dioxide results in decreased expression of PTEN mRNA CTD PMID:29128614 and PMID:29264374 toluene 2,4-diisocyanate multiple interactions ISO Pten (Mus musculus) 6480464 PTEN protein inhibits the reaction [Toluene 2 more ... CTD PMID:17982072 tributylstannane increases expression ISO PTEN (Homo sapiens) 6480464 tributyltin results in increased expression of PTEN mRNA CTD PMID:26314263 Tributyltin oxide increases expression ISO PTEN (Homo sapiens) 6480464 bis(tri-n-butyltin)oxide results in increased expression of PTEN mRNA CTD PMID:24247028 and PMID:26314263 trichloroethene multiple interactions EXP 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PTEN mRNA CTD PMID:17905399 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of PTEN mRNA CTD PMID:19448997 trichostatin A multiple interactions ISO PTEN (Homo sapiens) 6480464 [Doxorubicin co-treated with trichostatin A] results in increased expression of PTEN mRNA more ... CTD PMID:17330857 and PMID:27188386 trichostatin A increases expression ISO PTEN (Homo sapiens) 6480464 trichostatin A results in increased expression of PTEN mRNA and trichostatin A results in increased expression of PTEN protein CTD PMID:17330857 more ... triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of PTEN mRNA CTD PMID:30589522 Triptolide increases expression ISO Pten (Mus musculus) 6480464 triptolide results in increased expression of PTEN protein CTD PMID:30394310 Triptolide multiple interactions ISO Pten (Mus musculus) 6480464 NOTCH1 protein modified form inhibits the reaction [triptolide results in increased expression of PTEN protein] CTD PMID:30394310 Triptolide increases expression ISO PTEN (Homo sapiens) 6480464 triptolide results in increased expression of PTEN protein CTD PMID:30394310 trovafloxacin multiple interactions ISO Pten (Mus musculus) 6480464 [trovafloxacin co-treated with lipopolysaccharide and E coli O55-B5] results in decreased expression of PTEN mRNA CTD PMID:18930950 tubastatin A increases expression ISO PTEN (Homo sapiens) 6480464 tubastatin A results in increased expression of PTEN mRNA CTD PMID:34910997 tubastatin A multiple interactions ISO PTEN (Homo sapiens) 6480464 [bisphenol A co-treated with tubastatin A] results in increased expression of PTEN mRNA more ... CTD PMID:34910997 urethane increases expression ISO PTEN (Homo sapiens) 6480464 Urethane results in increased expression of PTEN mRNA CTD PMID:28818685 valproic acid decreases methylation ISO PTEN (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of PTEN gene CTD PMID:29154799 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of PTEN mRNA CTD PMID:29427782 valproic acid decreases expression ISO PTEN (Homo sapiens) 6480464 Valproic Acid results in decreased expression of PTEN mRNA CTD PMID:28001369 valproic acid multiple interactions ISO PTEN (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PTEN mRNA CTD PMID:27188386 valproic acid increases expression ISO PTEN (Homo sapiens) 6480464 Valproic Acid results in increased expression of PTEN mRNA CTD PMID:26272509 veliparib decreases response to substance ISO Pten (Mus musculus) 6480464 PTEN protein results in decreased susceptibility to veliparib CTD PMID:20530668 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of PTEN mRNA CTD PMID:15686871 vinyl carbamate decreases expression ISO Pten (Mus musculus) 6480464 vinyl carbamate results in decreased expression of PTEN mRNA CTD PMID:17849452 vorinostat decreases expression ISO PTEN (Homo sapiens) 6480464 vorinostat results in decreased expression of PTEN mRNA CTD PMID:27188386 WIN 55212-2 affects expression EXP 6480464 (3R)-((2 more ... CTD PMID:32833042 WIN 55212-2 multiple interactions EXP 6480464 [(3R)-((2 more ... CTD PMID:32833042 wortmannin multiple interactions ISO PTEN (Homo sapiens) 6480464 Wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Doxorubicin] more ... CTD PMID:17935137 and PMID:36190352 wortmannin multiple interactions EXP 6480464 Wortmannin inhibits the reaction [nonylphenol results in decreased expression of PTEN protein] more ... CTD PMID:20100827 more ... zearalenone increases expression ISO Pten (Mus musculus) 6480464 Zearalenone results in increased expression of PTEN mRNA CTD PMID:30717214 zearalenone decreases expression ISO Pten (Mus musculus) 6480464 Zearalenone results in decreased expression of PTEN protein CTD PMID:27473017 zinc atom multiple interactions ISO PTEN (Homo sapiens) 6480464 PTEN protein inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA] and PTEN protein inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein] CTD PMID:15980035 zinc atom increases degradation ISO PTEN (Homo sapiens) 6480464 Zinc results in increased degradation of PTEN protein CTD PMID:15980035 zinc sulfate multiple interactions ISO PTEN (Homo sapiens) 6480464 PTEN mutant form inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA] and PTEN promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA] CTD PMID:21883094 zinc sulfate increases ubiquitination EXP 6480464 Zinc Sulfate results in increased ubiquitination of PTEN protein CTD PMID:20100827 zinc sulfate multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zinc Sulfate results in decreased stability of PTEN protein] more ... CTD PMID:20100827 zinc sulfate increases response to substance EXP 6480464 PTEN protein results in increased susceptibility to Zinc Sulfate CTD PMID:20100827 zinc sulfate decreases expression ISO Pten (Mus musculus) 6480464 Zinc Sulfate results in decreased expression of PTEN protein CTD PMID:20100827 zinc(0) multiple interactions ISO PTEN (Homo sapiens) 6480464 PTEN protein inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA] and PTEN protein inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein] CTD PMID:15980035 zinc(0) increases degradation ISO PTEN (Homo sapiens) 6480464 Zinc results in increased degradation of PTEN protein CTD PMID:15980035