Gene: Pklr (pyruvate kinase, liver and RBC) Rattus norvegicus
Symbol: Pklr
Name: pyruvate kinase, liver and RBC
Description: ENCODES a protein that exhibits pyruvate kinase activity; INVOLVED IN ATP biosynthetic process; carbohydrate metabolic process; cellular response to epinephrine stimulus; PARTICIPATES IN glycolysis pathway; pyruvate metabolic pathway; fanconi syndrome pathway; ASSOCIATED WITH Burns; Diabetes Mellitus, Experimental; Hyperglycemia; FOUND IN cytosol; extracellular exosome (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: L-PK; PK1; PKL; Pklg; pyruvate kinase isozymes L/R; pyruvate kinase isozymes R/L; pyruvate kinase PKLR; pyruvate kinase, liver and red blood cell
Homo sapiens (human) : PKLR (pyruvate kinase, liver and RBC)  HGNC
Mus musculus (house mouse) : Pklr (pyruvate kinase liver and red blood cell)  MGI
Pan paniscus (bonobo/pygmy chimpanzee) : PKLR (pyruvate kinase, liver and RBC)
Canis lupus familiaris (dog) : PKLR (pyruvate kinase, liver and RBC)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pklr (pyruvate kinase, liver and RBC)
more info ...
Is Marker For: Strains:   WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc   WKY.SHRSP-(Fst-Pklr)/Gcrc  
QTLs:   Niddm8  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02188,449,158 - 188,458,034 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.02207,865,529 - 207,874,394 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.42181,214,853 - 181,223,505 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12181,164,961 - 181,173,618 (+)NCBI
Celera2168,486,468 - 168,494,841 (+)NCBI
Cytogenetic Map2q34NCBImapview
RH 3.4 Map21154.4RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pklr
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 3336
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-04-04
Status: ACTIVE