Gene: Sirt1 (sirtuin 1) Rattus norvegicus
Symbol: Sirt1
Name: sirtuin 1
Description: ENCODES a protein that exhibits enzyme binding; NAD-dependent histone deacetylase activity; protein kinase B binding; INVOLVED IN cell aging; cellular response to antibiotic; cellular response to beta-amyloid; PARTICIPATES IN histone modification pathway; p53 signaling pathway; RNA polymerase I transcription pathway; ASSOCIATED WITH Acute Kidney Injury; Atherosclerosis; Binge Drinking; FOUND IN axon; cytosol; growth cone; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (R)-lipoic acid
Type: protein-coding
RefSeq Status: MODEL
Also known as: NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; Sir2; Sir2alpha; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
Orthologs:
Homo sapiens : SIRT1 (sirtuin 1)  HGNC
Mus musculus : Sirt1 (sirtuin 1)  MGI
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02026,831,971 - 26,851,587 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0208,139,854 - 8,159,830 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.42025,675,302 - 25,686,494 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12025,681,998 - 25,700,388 (-)NCBI
Celera2026,607,505 - 26,627,344 (+)NCBI
Cytogenetic Map20p11NCBImapview
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants