Gene: Psen1 (presenilin 1) Rattus norvegicus
Analyze
Symbol: Psen1
Name: presenilin 1
Description: ENCODES a protein that exhibits endopeptidase activity; peptidase activity; beta-catenin binding (ortholog); INVOLVED IN membrane protein ectodomain proteolysis; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; syndecan signaling pathway; ASSOCIATED WITH increased apoptosis; ASSOCIATED WITH Alzheimer Disease (ortholog); Alzheimer Disease Type 4 (ortholog); Alzheimer Disease, Familial, 3, with Spastic Paraparesis (ortholog); FOUND IN cell surface; lysosomal membrane; membrane raft; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,6-dinitrotoluene; 6-propyl-2-thiouracil
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: presenilin-1; PS-1
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06107,169,514 - 107,221,000 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.06118,324,910 - 118,373,090 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.46107,737,543 - 107,776,357 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16107,729,188 - 107,781,021 (+)NCBI
Celera6101,163,513 - 101,199,486 (+)NCBI
Cytogenetic Map6q24NCBImapview
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Psen1
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 3425
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2016-11-18
Status: ACTIVE