Cdsn (corneodesmosin) - Rat Genome Database

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Gene: Cdsn (corneodesmosin) Rattus norvegicus
Analyze
Symbol: Cdsn
Name: corneodesmosin
RGD ID: 1598543
Description: Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including amyloid fibril formation; corneocyte desquamation; and negative regulation of cornification. Predicted to act upstream of or within cell-cell adhesion. Located in extracellular region. Human ortholog(s) of this gene implicated in alopecia; hypotrichosis 2; and peeling skin syndrome 1. Orthologous to human CDSN (corneodesmosin); INTERACTS WITH paraquat; 1,1-dichloroethene (ortholog); 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC682408; similar to corneodesmosin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,184,142 - 3,188,962 (-)NCBIGRCr8
mRatBN7.2203,179,432 - 3,184,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,179,438 - 3,184,250 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx203,240,743 - 3,245,574 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,245,714 - 3,250,545 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0203,269,983 - 3,274,788 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,704,626 - 3,707,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0205,792,983 - 5,795,590 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera20606,557 - 612,794 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization. Broccardo CJ, etal., J Allergy Clin Immunol. 2011 Jan;127(1):186-93, 193.e1-11. doi: 10.1016/j.jaci.2010.10.033.
2. Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin. Levy-Nissenbaum E, etal., Nat Genet. 2003 Jun;34(2):151-3.
3. Corneodesmosin, a corneodesmosome-specific basic protein, is expressed in the cornified epithelia of the pig, guinea pig, rat, and mouse. Montezin M, etal., Exp Cell Res. 1997 Feb 25;231(1):132-40.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9395522   PMID:11279026   PMID:11739386   PMID:15060004   PMID:15086562   PMID:20691404   PMID:23376485   PMID:24006456   PMID:26014679   PMID:33450132  


Genomics

Comparative Map Data
Cdsn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,184,142 - 3,188,962 (-)NCBIGRCr8
mRatBN7.2203,179,432 - 3,184,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,179,438 - 3,184,250 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx203,240,743 - 3,245,574 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,245,714 - 3,250,545 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0203,269,983 - 3,274,788 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,704,626 - 3,707,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0205,792,983 - 5,795,590 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera20606,557 - 612,794 (-)NCBICelera
Cytogenetic Map20p12NCBI
CDSN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,115,087 - 31,120,446 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,115,087 - 31,120,446 (-)EnsemblGRCh38hg38GRCh38
GRCh37631,082,864 - 31,088,223 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,190,849 - 31,196,202 (-)NCBINCBI36Build 36hg18NCBI36
Build 34631,191,339 - 31,196,189NCBI
Celera632,683,083 - 32,688,466 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,885,378 - 30,890,761 (-)NCBIHuRef
CHM1_1631,084,956 - 31,090,339 (-)NCBICHM1_1
T2T-CHM13v2.0630,982,815 - 30,988,170 (-)NCBIT2T-CHM13v2.0
Cdsn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,854,044 - 35,867,811 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,863,025 - 35,868,077 (+)EnsemblGRCm39 Ensembl
GRCm381735,543,101 - 35,557,180 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,552,128 - 35,557,180 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,689,073 - 35,694,125 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,160,194 - 35,165,233 (+)NCBIMGSCv36mm8
Celera1739,067,633 - 39,072,920 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.7NCBI
Cdsn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955583958,668 - 964,149 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955583959,544 - 968,632 (-)NCBIChiLan1.0ChiLan1.0
CDSN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2545,676,973 - 45,682,857 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1641,640,163 - 41,646,043 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0630,861,199 - 30,867,082 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1631,726,602 - 31,731,976 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl631,727,090 - 31,731,976 (-)Ensemblpanpan1.1panPan2
CDSN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112819,488 - 824,015 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12820,467 - 823,986 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12952,855 - 961,585 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012128,294 - 132,529 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12127,597 - 132,340 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112823,625 - 827,971 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012891,795 - 896,141 (-)NCBIUNSW_CanFamBas_1.0
Cdsn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494634,421,192 - 34,426,175 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936837787,301 - 791,388 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936837787,035 - 791,388 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDSN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,520,142 - 23,524,372 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,520,142 - 23,524,372 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,309,334 - 27,313,556 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDSN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,352,063 - 41,359,344 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604430,808,711 - 30,814,631 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdsn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,796,341 - 24,799,913 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,796,308 - 24,800,324 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdsn
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:69
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000071981
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013624629Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat

Markers in Region
RH132531  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera20610,576 - 610,755UniSTS
RH 3.4 Map2052.3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071981   ⟹   ENSRNOP00000078238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,179,438 - 3,184,250 (-)Ensembl
Rnor_6.0 Ensembl203,705,292 - 3,706,843 (-)Ensembl
RefSeq Acc Id: NM_001399511   ⟹   NP_001386440
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,184,142 - 3,188,962 (-)NCBI
mRatBN7.2203,179,432 - 3,184,252 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386440 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE84024 (Get FASTA)   NCBI Sequence Viewer  
  EDL86765 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000078238
  ENSRNOP00000078238.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000078238   ⟸   ENSRNOT00000071981
RefSeq Acc Id: NP_001386440   ⟸   NM_001399511
- Peptide Label: precursor
- UniProtKB: A0A8I5ZKH8 (UniProtKB/TrEMBL),   A6KTB1 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598543 AgrOrtholog
BioCyc Gene G2FUF-4748 BioCyc
Ensembl Genes ENSRNOG00000050215 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071981 ENTREZGENE
  ENSRNOT00000071981.4 UniProtKB/TrEMBL
InterPro Corneodesmosin UniProtKB/TrEMBL
NCBI Gene Cdsn ENTREZGENE
PANTHER CORNEODESMOSIN UniProtKB/TrEMBL
  PTHR23207 UniProtKB/TrEMBL
PhenoGen Cdsn PhenoGen
RatGTEx ENSRNOG00000050215 RatGTEx
UniProt A0A8I5ZKH8 ENTREZGENE, UniProtKB/TrEMBL
  A6KTB1 ENTREZGENE, UniProtKB/TrEMBL
  Q6MG23_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-13 Cdsn  corneodesmosin  LOC682408  similar to corneodesmosin  Data merged from RGD:1583483 737654 APPROVED
2015-11-13 Cdsn  corneodesmosin  Cdsn  corneodesmosin  Type changed (type changed from [null] to [protein-coding]) 629549 APPROVED
2006-12-03 Cdsn  corneodesmosin      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682408  similar to corneodesmosin      Symbol and Name status set to provisional 70820 PROVISIONAL