Klf10 (KLF transcription factor 10) - Rat Genome Database

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Gene: Klf10 (KLF transcription factor 10) Rattus norvegicus
Analyze
Symbol: Klf10
Name: KLF transcription factor 10
RGD ID: 621652
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and core promoter sequence-specific DNA binding activity. Involved in cellular response to peptide and regulation of circadian rhythm. Located in nucleus. Orthologous to human KLF10 (KLF transcription factor 10); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Krueppel-like factor 10; Kruppel-like factor 10; TGFB inducible early growth response; TGFB-inducible early growth response protein 1; Tieg; TIEG-1; transforming growth factor-beta-inducible early growth response protein 1; zinc finger transcription factor homolog CPG20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8771,352,612 - 71,358,680 (-)NCBIGRCr8
mRatBN7.2769,467,658 - 69,473,726 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,465,619 - 69,473,994 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx771,347,410 - 71,353,478 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0773,549,944 - 73,556,012 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0773,417,968 - 73,424,036 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0777,156,010 - 77,162,096 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl777,156,006 - 77,162,148 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0777,258,859 - 77,265,053 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4773,821,190 - 73,826,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1773,842,010 - 73,847,864 (-)NCBI
Celera766,529,946 - 66,535,877 (-)NCBICelera
RH 3.4 Map7631.6RGD
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
atrazine  (ISO)
avobenzone  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
chromium atom  (ISO)
ciguatoxin CTX1B  (ISO)
Cinobufagin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP,ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycine betaine  (EXP)
glyphosate  (EXP)
graphene oxide  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
inulin  (ISO)
iron dichloride  (ISO)
kainic acid  (ISO)
leflunomide  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP,ISO)
nicotine  (ISO)
orphenadrine  (EXP)
paracetamol  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP,ISO)
raloxifene  (ISO)
ritodrine  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Cullingford TE, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms. Hevroni D, etal., J Mol Neurosci 1998 Apr;10(2):75-98.
4. Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork. Hirota T, etal., Genes Cells. 2010 Feb;15(2):111-21. doi: 10.1111/j.1365-2443.2009.01371.x. Epub 2010 Jan 13.
5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. Tachibana I, etal., J Clin Invest 1997 May 15;99(10):2365-74.
Additional References at PubMed
PMID:12477932   PMID:15087465   PMID:15657444   PMID:19379700   PMID:20155803   PMID:21856285   PMID:25448845   PMID:26252173  


Genomics

Comparative Map Data
Klf10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8771,352,612 - 71,358,680 (-)NCBIGRCr8
mRatBN7.2769,467,658 - 69,473,726 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,465,619 - 69,473,994 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx771,347,410 - 71,353,478 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0773,549,944 - 73,556,012 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0773,417,968 - 73,424,036 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0777,156,010 - 77,162,096 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl777,156,006 - 77,162,148 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0777,258,859 - 77,265,053 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4773,821,190 - 73,826,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1773,842,010 - 73,847,864 (-)NCBI
Celera766,529,946 - 66,535,877 (-)NCBICelera
RH 3.4 Map7631.6RGD
Cytogenetic Map7q22NCBI
KLF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388102,648,784 - 102,655,725 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8102,648,784 - 102,655,725 (-)EnsemblGRCh38hg38GRCh38
GRCh378103,661,012 - 103,667,953 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,730,188 - 103,737,128 (-)NCBINCBI36Build 36hg18NCBI36
Build 348103,730,196 - 103,737,128NCBI
Celera899,848,329 - 99,855,302 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef898,862,246 - 98,869,150 (-)NCBIHuRef
CHM1_18103,701,211 - 103,708,326 (-)NCBICHM1_1
T2T-CHM13v2.08103,777,028 - 103,783,970 (-)NCBIT2T-CHM13v2.0
Klf10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391538,291,702 - 38,300,950 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1538,291,707 - 38,300,950 (-)EnsemblGRCm39 Ensembl
GRCm381538,291,464 - 38,300,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1538,291,463 - 38,300,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv371538,224,168 - 38,230,462 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361538,239,002 - 38,245,296 (-)NCBIMGSCv36mm8
Celera1538,920,503 - 38,926,796 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.15NCBI
Klf10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541727,164,839 - 27,168,604 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541727,165,146 - 27,168,604 (-)NCBIChiLan1.0ChiLan1.0
KLF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27120,013,188 - 120,020,500 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1895,549,150 - 95,556,311 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0899,302,943 - 99,310,099 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18101,462,915 - 101,469,965 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8101,462,915 - 101,469,982 (-)Ensemblpanpan1.1panPan2
KLF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1134,216,745 - 4,223,708 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl134,218,084 - 4,223,691 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha134,218,182 - 4,224,873 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0134,376,923 - 4,383,610 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl134,376,925 - 4,383,607 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1134,219,256 - 4,225,960 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0134,336,504 - 4,343,201 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0134,349,283 - 4,355,987 (-)NCBIUU_Cfam_GSD_1.0
Klf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530333,554,546 - 33,560,778 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647040,980,487 - 40,986,885 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647040,980,487 - 40,986,880 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl434,429,941 - 34,436,004 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1434,430,132 - 34,435,990 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2437,443,363 - 37,449,221 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLF10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,496,695 - 97,503,818 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl897,496,678 - 97,503,620 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603943,100,548 - 43,107,671 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klf10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476319,581,730 - 19,587,730 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476319,582,019 - 19,592,447 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klf10
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:566
Count of miRNA genes:275
Interacting mature miRNAs:339
Transcripts:ENSRNOT00000008350
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat

Markers in Region
RH127848  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,467,809 - 69,467,989 (+)MAPPERmRatBN7.2
Rnor_6.0777,156,162 - 77,156,341NCBIRnor6.0
Rnor_5.0777,259,011 - 77,259,190UniSTSRnor5.0
RGSC_v3.4773,821,342 - 73,821,521UniSTSRGSC3.4
Celera766,530,098 - 66,530,277UniSTS
RH 3.4 Map7632.9UniSTS
Cytogenetic Map7q22UniSTS
Tieg  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,467,817 - 69,467,967 (+)MAPPERmRatBN7.2
Rnor_6.0777,156,170 - 77,156,319NCBIRnor6.0
Rnor_5.0777,259,019 - 77,259,168UniSTSRnor5.0
RGSC_v3.4773,821,350 - 73,821,499UniSTSRGSC3.4
Celera766,530,106 - 66,530,255UniSTS
RH 3.4 Map7631.6UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 48 32 19 32 7 10 68 28 35 11 7
Low 9 9 9 9 1 1 6 7 6 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008350   ⟹   ENSRNOP00000008350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl769,467,749 - 69,473,994 (-)Ensembl
Rnor_6.0 Ensembl777,156,006 - 77,162,148 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085626   ⟹   ENSRNOP00000070160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl769,465,619 - 69,473,994 (-)Ensembl
Rnor_6.0 Ensembl777,157,458 - 77,159,457 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094319   ⟹   ENSRNOP00000079465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl769,467,659 - 69,473,644 (-)Ensembl
RefSeq Acc Id: NM_031135   ⟹   NP_112397
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,352,612 - 71,358,680 (-)NCBI
mRatBN7.2769,467,658 - 69,473,726 (-)NCBI
Rnor_6.0777,156,010 - 77,162,096 (-)NCBI
Rnor_5.0777,258,859 - 77,265,053 (-)NCBI
RGSC_v3.4773,821,190 - 73,826,866 (-)RGD
Celera766,529,946 - 66,535,877 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264302   ⟹   XP_063120372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,352,612 - 71,358,243 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_112397   ⟸   NM_031135
- UniProtKB: Q4QRA4 (UniProtKB/Swiss-Prot),   O08876 (UniProtKB/Swiss-Prot),   A6HR55 (UniProtKB/TrEMBL),   P97848 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008350   ⟸   ENSRNOT00000008350
RefSeq Acc Id: ENSRNOP00000070160   ⟸   ENSRNOT00000085626
RefSeq Acc Id: ENSRNOP00000079465   ⟸   ENSRNOT00000094319
RefSeq Acc Id: XP_063120372   ⟸   XM_063264302
- Peptide Label: isoform X1
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08876-F1-model_v2 AlphaFold O08876 1-480 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695301
Promoter ID:EPDNEW_R5826
Type:initiation region
Name:Klf10_1
Description:Kruppel-like factor 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0777,162,157 - 77,162,217EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621652 AgrOrtholog
BioCyc Gene G2FUF-33591 BioCyc
Ensembl Genes ENSRNOG00000006118 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023377 UniProtKB/Swiss-Prot
  ENSRNOG00060009681 UniProtKB/Swiss-Prot
  ENSRNOG00065003814 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008350 ENTREZGENE
  ENSRNOT00000008350.4 UniProtKB/Swiss-Prot
  ENSRNOT00000085626.2 UniProtKB/TrEMBL
  ENSRNOT00000094319.1 UniProtKB/TrEMBL
  ENSRNOT00055040167 UniProtKB/Swiss-Prot
  ENSRNOT00060016330 UniProtKB/Swiss-Prot
  ENSRNOT00065005580 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7387595 IMAGE-MGC_LOAD
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81813 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114305 IMAGE-MGC_LOAD
NCBI Gene 81813 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klf10 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006118 RatGTEx
  ENSRNOG00055023377 RatGTEx
  ENSRNOG00060009681 RatGTEx
  ENSRNOG00065003814 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JX73_RAT UniProtKB/TrEMBL
  A0A8I6G3C1_RAT UniProtKB/TrEMBL
  A6HR55 ENTREZGENE, UniProtKB/TrEMBL
  KLF10_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P97848 ENTREZGENE, UniProtKB/TrEMBL
  Q4QRA4 ENTREZGENE
UniProt Secondary Q4QRA4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Klf10  KLF transcription factor 10  Klf10  Kruppel-like factor 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Klf10  Kruppel-like factor 10  Tieg  TGFB inducible early growth response  Symbol and Name updated 1299863 APPROVED
2005-01-20 Tieg  TGFB inducible early growth response      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tieg  TGFB inducible early growth response      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process induces apoptosis in TGFbeta-sensitive epithelial cell line PANC1 724783
gene_product member of Sp1-like zinc finger proteins 724783