Gene: Prkaa1 (protein kinase AMP-activated catalytic subunit alpha 1) Rattus norvegicus
Symbol: Prkaa1
Name: protein kinase AMP-activated catalytic subunit alpha 1
Description: ENCODES a protein that exhibits AMP-activated protein kinase activity; ATP binding; kinase binding; INVOLVED IN cellular response to ethanol; cellular response to hydrogen peroxide; cellular response to hypoxia; PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; vascular endothelial growth factor signaling pathway; autophagy pathway; ASSOCIATED WITH Diabetes Complications; Diabetes Mellitus, Type 2; Insulin Resistance; FOUND IN apical plasma membrane; cytoplasm; nucleotide-activated protein kinase complex; INTERACTS WITH 1,2,3,4,7,8-Hexachlorodibenzodioxin; 2,3,7,8-tetrachlorodibenzodioxine; 5-aminolevulinic acid
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5'-AMP-activated protein kinase alpha-1 catalytic subunit; 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5-AMP-activated protein kinase alpha-1 catalytic subunit; ACACA kinase; acetyl-CoA carboxylase kinase; AMPK alpha-1 chain; AMPK subunit alpha-1; AMPKalpha1; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase, AMP-activated, alpha 1 catalytic subunit; tau-protein kinase PRKAA1
Related Pseudogenes: LOC363815  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0254,857,688 - 54,893,404 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0273,882,080 - 73,917,812 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4254,327,821 - 54,360,462 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1254,256,055 - 54,288,695 (+)NCBI
Celera249,888,577 - 49,923,847 (+)NCBI
Cytogenetic Map2q16NCBImapview

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Prkaa1
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 3387
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2016-10-11
Status: ACTIVE