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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chrysin
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Accession:CHEBI:75095 term browser browse the term
Definition:A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.
Synonyms:related_synonym: 5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one;   5,7-Dihydroxy-2-phenyl-4H-benzo(b)pyran-4-one;   5,7-Dihydroxyflavone;   5,7-dihydroxy-2-phenylchromen-4-one;   Formula=C15H10O4;   InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H;   InChIKey=RTIXKCRFFJGDFG-UHFFFAOYSA-N;   SMILES=Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1
 alt_id: CHEBI:3683
 xref: Beilstein:233276;   CAS:480-40-0;   HMDB:HMDB0036619;   KEGG:C10028;   KNApSAcK:C00003794;   LINCS:LSM-6566;   LIPID_MAPS_instance:LMPK12110189
 xref_mesh: MESH:C043561
 xref: MetaCyc:CPD-8184;   PDBeChem:57D;   PMID:1772594;   PMID:21544919;   PMID:22864849;   PMID:22991264;   PMID:23104078;   PMID:23125118;   PMID:23194824;   PMID:23256457;   PMID:23296950;   PMID:23357962;   PMID:23468207;   PMID:23536316;   PMID:23636231;   PMID:23744338;   PMID:23888052;   PMID:23945741;   PMID:23962900;   Reaxys:233276;   Wikipedia:Chrysin



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chrysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects activity
increases expression
decreases activity
multiple interactions
ISO chrysin affects the activity of ABCB1 protein
chrysin results in increased expression of ABCB1 protein
chrysin results in decreased activity of ABCB1 protein
[chrysin results in decreased activity of ABCB1 protein] which results in decreased export of Topotecan
CTD PMID:15796199 PMID:20457140 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO ABCC1 protein affects the reaction [chrysin results in increased transport of Glutathione] CTD PMID:21856323 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
decreases activity
ISO [chrysin results in decreased activity of ABCC2 protein] which results in decreased export of Topotecan; chrysin inhibits the reaction [ABCC2 protein affects the export of ochratoxin A]
chrysin results in increased expression of ABCC2 protein
CTD PMID:15955639 PMID:20457140 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO ABCC3 protein affects the reaction [chrysin results in increased transport of Glutathione] CTD PMID:21856323 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
decreases expression
ISO ABCC5 protein affects the reaction [chrysin results in increased transport of Glutathione]
chrysin results in decreased expression of ABCC5 mRNA; chrysin results in decreased expression of ABCC5 protein
CTD PMID:21856323 PMID:23994249 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases activity
increases expression
decreases expression
ISO
EXP
[chrysin results in decreased activity of ABCG2 protein] which results in decreased export of Topotecan; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]
chrysin results in increased expression of ABCG2 mRNA; chrysin results in increased expression of ABCG2 protein
chrysin results in decreased expression of ABCG2 mRNA
chrysin inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]
CTD PMID:17077187 PMID:17093006 PMID:19732493 PMID:20457140 PMID:20816778 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA] CTD PMID:26297989 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Afp alpha-fetoprotein affects binding EXP chrysin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Ahr aryl hydrocarbon receptor affects activity
multiple interactions
ISO
EXP
chrysin affects the activity of AHR protein
chrysin binds to and results in increased activity of AHR protein
[chrysin co-treated with Methylcholanthrene] affects the activity of AHR protein; [chrysin co-treated with Tetrachlorodibenzodioxin] affects the activity of AHR protein; chrysin binds to and results in increased activity of AHR protein; chrysin inhibits the reaction [AHR protein binds to CYP1A1 promoter]; chrysin inhibits the reaction [AHR protein binds to UGT1A1 promoter]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; chrysin promotes the reaction [AHR protein binds to CYP1A1 promoter]
CTD PMID:14644660 PMID:16972788 PMID:17256720 PMID:19286049 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 decreases expression ISO chrysin results in decreased expression of AKR1B10 mRNA; chrysin results in decreased expression of AKR1B10 protein CTD PMID:23994249 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO BCL2 protein inhibits the reaction [chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; chrysin inhibits the reaction [AKT1 protein results in increased expression of MMP10 protein]; chrysin inhibits the reaction [AKT1 protein results in increased expression of SNAI1 protein]; chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein
chrysin results in decreased phosphorylation of AKT1 protein
CTD PMID:16215670 PMID:18455702 PMID:24122885 PMID:30578657 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions EXP chrysin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein] CTD PMID:30794797 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Apob apolipoprotein B multiple interactions ISO chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of APOB mRNA]; chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of APOB protein] CTD PMID:32220030 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO chrysin promotes the reaction [ARNT protein binds to CYP1A1 promoter] CTD PMID:16972788 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions EXP chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 protein] CTD PMID:21167192 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
chrysin inhibits the reaction [Isoniazid results in increased expression of BAX protein]; chrysin inhibits the reaction [Testosterone results in decreased expression of BAX mRNA]; chrysin promotes the reaction [Diethylnitrosamine results in increased expression of BAX protein]
[Cisplatin co-treated with chrysin] results in increased expression of BAX protein
CTD PMID:21167192 PMID:25770930 PMID:29247772 PMID:33121995 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases response to substance
ISO
EXP
BCL2 protein inhibits the reaction [chrysin results in decreased expression of XIAP protein]; BCL2 protein inhibits the reaction [chrysin results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; BCL2 protein inhibits the reaction [chrysin results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [chrysin results in increased degradation of PLCG1 protein]; chrysin inhibits the reaction [Cisplatin results in increased expression of BCL2 protein]
chrysin inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA]
BCL2 protein results in decreased susceptibility to chrysin
CTD PMID:16215670 PMID:25770930 PMID:29247772 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] CTD PMID:21167192 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions
ISO chrysin results in increased expression of BDNF protein
chrysin inhibits the reaction [Oxidopamine results in decreased expression of BDNF protein]
CTD PMID:29054324 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp1 caspase 1 multiple interactions ISO chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CASP1 protein] CTD PMID:21515303 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO
EXP
[Cisplatin co-treated with chrysin] results in increased cleavage of CASP3 protein; BCL2 protein inhibits the reaction [chrysin results in increased cleavage of and results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased cleavage of CASP3 protein]; chrysin inhibits the reaction [Topotecan results in increased activity of CASP3 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP3 protein]; chrysin results in increased cleavage of and results in increased activity of CASP3 protein
chrysin results in increased cleavage of CASP3 protein
[Diethylnitrosamine co-treated with chrysin] results in increased expression of CASP3 protein; chrysin inhibits the reaction [Acetaminophen results in increased activity of CASP3 protein]; chrysin inhibits the reaction [Colistin results in increased expression of CASP3 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased activity of CASP3 protein]; chrysin inhibits the reaction [Testosterone results in decreased cleavage of CASP3 protein]; chrysin inhibits the reaction [Thioacetamide results in increased expression of CASP3 protein]
CTD PMID:16215670 PMID:18331776 PMID:19397994 PMID:20457140 PMID:21167192 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
ISO [Cisplatin co-treated with chrysin] results in increased cleavage of CASP8 protein; chrysin inhibits the reaction [Topotecan results in increased activity of CASP8 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP8 protein]
chrysin results in increased cleavage of CASP8 protein
CTD PMID:20457140 PMID:21195158 PMID:25770930 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO chrysin results in increased cleavage of CASP9 protein
[Cisplatin co-treated with chrysin] results in increased cleavage of CASP9 protein
CTD PMID:18331776 PMID:25770930 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP
ISO
chrysin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; chrysin inhibits the reaction [Colistin results in decreased activity of CAT protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; chrysin inhibits the reaction [Isoniazid results in decreased activity of CAT protein]; chrysin inhibits the reaction [Testosterone results in decreased activity of CAT protein]
chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased activity of CAT protein]
chrysin results in decreased activity of CAT protein
CTD PMID:10647909 PMID:23194824 PMID:28682524 PMID:29247772 PMID:30273961 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO chrysin results in decreased expression of CCNB1 mRNA; chrysin results in decreased expression of CCNB1 protein CTD PMID:18331776 PMID:19397994 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdh1 cadherin 1 increases expression ISO chrysin results in increased expression of CDH1 protein CTD PMID:24122885 PMID:30578657 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO chrysin results in decreased expression of CDH2 protein CTD PMID:30578657 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO
EXP
chrysin results in increased expression of CDKN1A mRNA; chrysin results in increased expression of CDKN1A protein
chrysin inhibits the reaction [Testosterone results in decreased expression of CDKN1A mRNA]
CTD PMID:19397994 PMID:29247772 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C decreases expression ISO chrysin results in decreased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO chrysin inhibits the reaction [Topotecan results in increased cleavage of CTNNB1 protein] CTD PMID:20457140 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; chrysin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA] CTD PMID:19426678 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
multiple interactions
ISO chrysin results in decreased activity of CYP19A1 protein
chrysin binds to and results in decreased activity of CYP19A1 protein
CTD PMID:9435150 PMID:10403137 PMID:15319488 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases oxidation
increases expression
increases metabolic processing
decreases activity
increases activity
ISO [CYP1A1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; chrysin inhibits the reaction [AHR protein binds to CYP1A1 promoter]; chrysin inhibits the reaction [CYP1A1 results in increased activity of Benzo(a)pyrene]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; chrysin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; chrysin promotes the reaction [AHR protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ARNT protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]
CYP1A1 protein results in increased oxidation of chrysin
chrysin results in increased expression of CYP1A1 mRNA
chrysin promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
chrysin results in increased expression of CYP1A1 mRNA; chrysin results in increased expression of CYP1A1 protein
chrysin results in decreased activity of CYP1A1 protein
chrysin results in increased activity of CYP1A1 protein
CTD PMID:11752233 PMID:16972788 PMID:17012224 PMID:17256720 PMID:19666078 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
increases oxidation
multiple interactions
decreases activity
ISO CYP1A2 protein results in increased metabolism of chrysin
CYP1A2 protein results in increased oxidation of chrysin
[CYP1A2 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein
chrysin results in decreased activity of CYP1A2 protein
CTD PMID:19666078 PMID:20806393 PMID:21053930 PMID:30964977 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases oxidation
increases metabolic processing
decreases activity
ISO [CYP1B1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein; chrysin binds to and results in decreased activity of CYP1B1 protein
CYP1B1 protein alternative form results in increased oxidation of chrysin
chrysin results in decreased activity of CYP1B1 protein
CTD PMID:19666078 PMID:21053930 PMID:21482471 PMID:30964977 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases oxidation ISO CYP2A13 protein results in increased oxidation of chrysin CTD PMID:30964977 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [chrysin results in increased expression of CYP2B10 mRNA] CTD PMID:25625231 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO chrysin results in increased expression of CYP2B6 mRNA CTD PMID:25625231 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions ISO chrysin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen] CTD PMID:21053930 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
multiple interactions
ISO chrysin results in increased activity of CYP3A4 protein
[[chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; chrysin binds to and results in decreased activity of CYP3A4 protein; chrysin inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein]
CTD PMID:19766177 PMID:21053930 PMID:31756459 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Edn1 endothelin 1 increases expression ISO chrysin results in increased expression of EDN1 mRNA CTD PMID:18457675 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Egf epidermal growth factor multiple interactions ISO chrysin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; chrysin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO chrysin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:25625231 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO chrysin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein] CTD PMID:25625231 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO chrysin binds to and results in increased activity of ESR1 protein; chrysin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; chrysin promotes the reaction [ESR1 protein binds to TFF1 promoter] CTD PMID:9751507 PMID:16972788 PMID:29162470 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 affects binding
multiple interactions
ISO chrysin binds to ESR2 protein
chrysin binds to and results in increased activity of ESR2 protein
CTD PMID:9751507 PMID:12224631 PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression ISO chrysin results in decreased expression of FADS2 mRNA CTD PMID:20816778 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
JBrowse link
G Faslg Fas ligand multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of FASLG mRNA] CTD PMID:24932515 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression ISO chrysin results in decreased expression of FBP1 mRNA CTD PMID:18331776 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
JBrowse link
G Fn1 fibronectin 1 increases expression ISO chrysin results in increased expression of FN1 protein CTD PMID:26408079 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]] CTD PMID:15322261 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of FSHB protein] CTD PMID:24932515 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO chrysin results in increased expression of GADD45B mRNA; chrysin results in increased expression of GADD45B protein CTD PMID:18331776 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
EXP [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [chrysin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; chrysin inhibits the reaction [Isoniazid results in increased expression of GCLC mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLC protein]
chrysin results in increased expression of GCLC mRNA; chrysin results in increased expression of GCLC protein
CTD PMID:22864849 PMID:33121995 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
EXP [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [chrysin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; chrysin inhibits the reaction [Isoniazid results in increased expression of GCLM mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLM protein]
chrysin results in increased expression of GCLM mRNA; chrysin results in increased expression of GCLM protein
CTD PMID:22864849 PMID:33121995 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in decreased expression of GDNF protein] CTD PMID:29054324 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP mRNA]; chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP protein] CTD PMID:33121995 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP chrysin inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; chrysin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:28682524 PMID:30794797 PMID:31625388 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO chrysin results in decreased expression of GRB2 protein CTD PMID:30578657 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [chrysin results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP chrysin results in decreased activity of GSR protein CTD PMID:10647909 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
increases expression
EXP
ISO
[chrysin results in increased expression of HMOX1 mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide; [zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; chrysin inhibits the reaction [Isoniazid results in increased expression of HMOX1 mRNA]; MAPK1 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
chrysin results in decreased expression of HMOX1 mRNA; chrysin results in decreased expression of HMOX1 protein
chrysin results in increased expression of HMOX1 mRNA; chrysin results in increased expression of HMOX1 protein
CTD PMID:22864849 PMID:23994249 PMID:33121995 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions ISO chrysin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased phosphorylation of and affects the localization of HNF4A protein]
chrysin inhibits the reaction [Hydrogen Peroxide results in decreased expression of HNF4A mRNA]; chrysin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of HNF4A protein]
CTD PMID:32220030 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15322261 PMID:16987811 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in increased expression of IFNG protein] CTD PMID:29054324 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP chrysin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA] CTD PMID:29247772 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions EXP chrysin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA] CTD PMID:29247772 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of IKBKB protein] CTD PMID:30016632 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il10 interleukin 10 multiple interactions EXP
ISO
chrysin inhibits the reaction [Freund's Adjuvant results in decreased expression of IL10 protein]
chrysin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]
chrysin inhibits the reaction [Oxidopamine results in decreased expression of IL10 protein]
CTD PMID:24932515 PMID:29054324 PMID:30016632 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il15 interleukin 15 decreases expression ISO chrysin results in decreased expression of IL15 mRNA CTD PMID:20816778 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL1B mRNA]; chrysin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; chrysin inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]
chrysin inhibits the reaction [Oxidopamine results in increased expression of IL1B protein]
chrysin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of IL1B mRNA]
chrysin results in decreased expression of IL1B mRNA
CTD PMID:18377686 PMID:20816778 PMID:21515303 PMID:28682524 PMID:29054324 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO chrysin results in decreased expression of IL1R1 mRNA CTD PMID:20816778 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
JBrowse link
G Il4 interleukin 4 multiple interactions ISO chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 mRNA] CTD PMID:21515303 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases expression
ISO
EXP
chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL6 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]
chrysin inhibits the reaction [Oxidopamine results in increased expression of IL6 protein]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of IL6 mRNA]; chrysin inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
chrysin results in increased expression of IL6 mRNA
chrysin results in decreased expression of IL6 mRNA
CTD PMID:18457675 PMID:20816778 PMID:21515303 PMID:23194824 PMID:29054324 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO chrysin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA] CTD PMID:19426678 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases phosphorylation
ISO chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; chrysin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]
chrysin results in decreased phosphorylation of JUN protein
CTD PMID:15322261 PMID:30578657 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lamb2 laminin subunit beta 2 increases expression ISO chrysin results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of LHB protein] CTD PMID:24932515 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP chrysin inhibits the reaction [Acetaminophen results in increased expression of MAP1LC3B protein]; chrysin inhibits the reaction [Colistin results in increased expression of MAP1LC3B protein] CTD PMID:28682524 PMID:30273961 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity
EXP
ISO
MAPK1 protein affects the reaction [chrysin results in increased expression of GCLC protein]; MAPK1 protein affects the reaction [chrysin results in increased expression of GCLM protein]; MAPK1 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
[chrysin co-treated with Cisplatin] results in increased phosphorylation of MAPK1 protein
chrysin results in increased phosphorylation of MAPK1 protein
chrysin results in increased activity of MAPK1 protein
CTD PMID:22864849 PMID:25770930 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [chrysin co-treated with Cisplatin] results in increased phosphorylation of MAPK3 protein
chrysin results in increased phosphorylation of MAPK3 protein
CTD PMID:25770930 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression ISO chrysin results in decreased expression of MMP1 protein CTD PMID:30578657 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp10 matrix metallopeptidase 10 multiple interactions
decreases expression
ISO chrysin inhibits the reaction [AKT1 protein results in increased expression of MMP10 protein]
chrysin results in decreased expression of MMP10 protein
CTD PMID:24122885 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
ISO chrysin results in decreased expression of and results in decreased activity of MMP2 protein
chrysin results in decreased activity of MMP2 protein
CTD PMID:26408079 PMID:30578657 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO chrysin inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein] CTD PMID:30016632 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in increased activity of MPO protein] CTD PMID:24932515 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression
multiple interactions
ISO chrysin results in increased expression of MYBL1 mRNA
Fulvestrant inhibits the reaction [chrysin results in increased expression of MYBL1 mRNA]
CTD PMID:33405908 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of MYD88 protein] CTD PMID:30016632 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression
EXP
ISO
chrysin affects the localization of and results in increased activity of NFE2L2 protein; chrysin inhibits the reaction [Isoniazid results in increased expression of NFE2L2 mRNA]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [chrysin results in increased expression of HMOX1 protein]
chrysin inhibits the reaction [NFE2L2 protein results in decreased susceptibility to Doxorubicin]
chrysin results in decreased expression of NFE2L2 mRNA; chrysin results in decreased expression of NFE2L2 protein
CTD PMID:22864849 PMID:23994249 PMID:33121995 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP chrysin inhibits the reaction [Isoniazid results in increased expression of NFKB1 mRNA]; chrysin inhibits the reaction [Thioacetamide results in increased expression of NFKB1 protein] CTD PMID:30500344 PMID:33121995 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
ISO chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased degradation of NFKBIA protein]; chrysin inhibits the reaction [IL1B protein results in increased phosphorylation of NFKBIA protein]; chrysin inhibits the reaction [nickel chloride results in increased phosphorylation of NFKBIA protein]
chrysin results in decreased expression of NFKBIA protein
CTD PMID:18377686 PMID:21515303 PMID:30016632 PMID:30578657 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in decreased expression of NGF protein] CTD PMID:29054324 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of NOS2 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of NOS2 protein]
CTD PMID:11343698 PMID:16934226 PMID:17570322 PMID:23194824 PMID:24932515 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP chrysin inhibits the reaction [alpha-naphthyl thiourea results in decreased expression of NOS3 mRNA] CTD PMID:30974023 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP chrysin inhibits the reaction [Isoniazid results in increased expression of NQO1 mRNA] CTD PMID:33121995 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO chrysin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO chrysin binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
multiple interactions
ISO chrysin affects the localization of NR1I3 protein
NR1I3 gene mutant form inhibits the reaction [chrysin results in increased expression of CYP2B10 mRNA]
CTD PMID:25625231 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO chrysin results in increased cleavage of PARP1 protein
[Cisplatin co-treated with chrysin] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased cleavage of PARP1 protein]
CTD PMID:18455702 PMID:25770930 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein]; chrysin inhibits the reaction [Testosterone results in increased expression of PCNA protein] CTD PMID:23194824 PMID:29247772 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity ISO chrysin results in decreased activity of PGD protein CTD PMID:25130191 NCBI chr 5:159,582,746...159,598,945 JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO chrysin results in decreased expression of PLAU protein CTD PMID:30578657 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
increases degradation
ISO BCL2 protein inhibits the reaction [chrysin results in increased degradation of PLCG1 protein] CTD PMID:16215670 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYP2A6 protein co-treated with POR protein] results in increased oxidation of chrysin CTD PMID:30964977 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO chrysin results in decreased expression of PPARA mRNA CTD PMID:20816778 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO chrysin binds to and results in increased activity of PPARG protein; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] CTD PMID:11343698 PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Psca prostate stem cell antigen decreases expression ISO chrysin results in decreased expression of PSCA mRNA CTD PMID:18331776 NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
chrysin results in increased expression of PTGS2 mRNA
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of PTGS2 protein]
chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; PPARG protein affects the reaction [chrysin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
CTD PMID:11343698 PMID:18457675 PMID:21167192 PMID:23194824 PMID:24932515 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO chrysin results in decreased phosphorylation of PTK2 protein CTD PMID:30578657 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
increases activity
ISO
EXP
Acetylcysteine inhibits the reaction [chrysin results in increased activity of RELA protein]; chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of RELA protein]; chrysin inhibits the reaction [nickel chloride affects the localization of RELA protein]; SB 203580 inhibits the reaction [chrysin results in increased activity of RELA protein]
chrysin results in decreased expression of RELA protein
chrysin inhibits the reaction [Oxidopamine results in increased phosphorylation of RELA protein]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein]; chrysin inhibits the reaction [Testosterone results in increased activity of RELA protein]
CTD PMID:18457675 PMID:21167192 PMID:21515303 PMID:23194824 PMID:29054324 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO chrysin results in decreased expression of RHOA protein CTD PMID:30578657 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G RT1-Da RT1 class II, locus Da decreases expression ISO chrysin results in decreased expression of HLA-DRA mRNA CTD PMID:20816778 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G S100b S100 calcium binding protein B multiple interactions ISO chrysin inhibits the reaction [Oxidopamine results in increased expression of S100B protein] CTD PMID:29054324 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Sc5d sterol-C5-desaturase decreases expression ISO chrysin results in decreased expression of SC5D mRNA CTD PMID:20816778 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO chrysin results in decreased expression of SCD mRNA CTD PMID:20816778 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sele selectin E multiple interactions ISO chrysin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16987811 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Sfn stratifin increases expression ISO chrysin results in increased expression of SFN mRNA; chrysin results in increased expression of SFN protein CTD PMID:18331776 Ensembl chr 5:145,826,201...145,831,314 JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions
ISO chrysin results in increased expression of SGK1 mRNA
Fulvestrant inhibits the reaction [chrysin results in increased expression of SGK1 mRNA]
CTD PMID:33405908 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO chrysin binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [chrysin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD2 mRNA] CTD PMID:26297989 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:26297989 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression
multiple interactions
ISO chrysin results in decreased expression of SNAI1 protein
chrysin inhibits the reaction [AKT1 protein results in increased expression of SNAI1 protein]
CTD PMID:24122885 PMID:30578657 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO chrysin results in decreased expression of SNAI2 protein CTD PMID:24122885 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO chrysin results in decreased expression of SOS1 protein CTD PMID:30578657 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP chrysin inhibits the reaction [Freund's Adjuvant results in decreased expression of STAR mRNA] CTD PMID:24932515 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO SULT1A1 protein SNP results in increased sulfation of chrysin CTD PMID:17293380 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO SULT1E1 protein results in increased sulfation of and results in decreased activity of chrysin CTD PMID:17293380 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Tbk1 TANK-binding kinase 1 decreases activity ISO chrysin results in decreased activity of TBK1 protein CTD PMID:19426678 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO chrysin promotes the reaction [ESR1 protein binds to TFF1 promoter] CTD PMID:16972788 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] CTD PMID:26297989 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO chrysin binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO chrysin binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO
EXP
chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of TLR4 protein]
chrysin inhibits the reaction [Thioacetamide results in increased expression of TLR4 mRNA]
CTD PMID:30016632 PMID:30500344 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TNF mRNA]; chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein]; chrysin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; chrysin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; chrysin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; chrysin inhibits the reaction [TNF protein results in increased expression of SELE protein]; chrysin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein]; chrysin inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; chrysin inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of TNF protein]; chrysin inhibits the reaction [Thioacetamide results in increased expression of TNF protein]; Silymarin promotes the reaction [chrysin inhibits the reaction [Acetaminophen results in increased expression of TNF protein]]
chrysin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; chrysin inhibits the reaction [Oxidopamine results in increased expression of TNF protein]
CTD PMID:15322261 PMID:16934226 PMID:16987811 PMID:21515303 PMID:23194824 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance
ISO chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP3 protein]; chrysin promotes the reaction [TNFSF10 protein results in increased degradation of CASP8 protein]
chrysin results in increased susceptibility to TNFSF10 protein
CTD PMID:21195158 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tp53 tumor protein p53 increases degradation
multiple interactions
ISO
EXP
chrysin results in increased degradation of TP53 protein
[Cisplatin co-treated with chrysin] affects the localization of TP53 protein; [Cisplatin co-treated with chrysin] results in increased phosphorylation of and results in increased expression of TP53 protein; chrysin results in increased phosphorylation of and affects the localization of TP53 protein; U 0126 inhibits the reaction [[Cisplatin co-treated with chrysin] affects the localization of TP53 protein]; U 0126 inhibits the reaction [[Cisplatin co-treated with chrysin] results in increased phosphorylation of TP53 protein]
[Diethylnitrosamine co-treated with chrysin] results in increased expression of TP53 protein; chrysin inhibits the reaction [Diethylnitrosamine results in decreased expression of TP53 mRNA]; chrysin inhibits the reaction [Testosterone results in decreased expression of TP53 mRNA]
CTD PMID:14634213 PMID:21167192 PMID:25770930 PMID:29247772 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO chrysin results in increased expression of TP53I3 mRNA; chrysin results in increased expression of TP53I3 protein CTD PMID:18331776 PMID:19397994 NCBI chr13:69,612,605...69,655,018
Ensembl chr13:69,620,792...69,652,475
JBrowse link
G Tp63 tumor protein p63 increases expression ISO chrysin results in increased expression of TP63 protein CTD PMID:18331776 PMID:19397994 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Tp73 tumor protein p73 increases expression ISO chrysin results in increased expression of TP73 protein CTD PMID:18331776 PMID:19397994 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
JBrowse link
G Tyr tyrosinase increases expression ISO chrysin results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
affects glucuronidation
increases glucuronidation
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; chrysin inhibits the reaction [AHR protein binds to UGT1A1 promoter]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Ethinyl Estradiol]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin]; chrysin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Quercetin]; pyrazolanthrone inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; SB 203580 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]; U 0126 inhibits the reaction [chrysin results in increased expression of UGT1A1 mRNA]
UGT1A1 protein affects the glucuronidation of chrysin
UGT1A1 protein results in increased glucuronidation of chrysin
chrysin results in increased expression of UGT1A1; chrysin results in increased expression of UGT1A1 mRNA; chrysin results in increased expression of UGT1A1 protein
CTD PMID:10950852 PMID:11442279 PMID:14557274 PMID:15104253 PMID:16003560 More... NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects glucuronidation ISO UGT1A6 protein affects the glucuronidation of chrysin CTD PMID:10950852 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of chrysin CTD PMID:15502008 NCBI chr 9:88,739,577...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP
ISO
UGT1A8 protein results in increased glucuronidation of chrysin CTD PMID:14557274 PMID:15502008 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
affects glucuronidation
ISO UGT1A9 protein results in increased glucuronidation of chrysin
UGT1A9 protein affects the glucuronidation of chrysin
CTD PMID:10950852 PMID:14557274 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Utrn utrophin increases expression ISO chrysin results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions
ISO chrysin results in increased expression of VCAM1 mRNA
chrysin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:16987811 PMID:18457675 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
ISO
EXP
chrysin results in decreased expression of VEGFA protein
chrysin inhibits the reaction [alpha-naphthyl thiourea results in increased expression of VEGFA mRNA]
CTD PMID:30578657 PMID:30974023 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin decreases expression ISO chrysin results in decreased expression of VIM protein CTD PMID:24122885 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression
multiple interactions
ISO chrysin results in decreased expression of XIAP protein
BCL2 protein inhibits the reaction [chrysin results in decreased expression of XIAP protein]
CTD PMID:16215670 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
chrysin 5,7-dimethyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of BAX protein CTD PMID:21554863 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] CTD PMID:21554863 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions EXP 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein] CTD PMID:21554863 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] CTD PMID:21554863 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Csnk2b casein kinase 2 beta multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B protein] CTD PMID:21554863 NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine affects the localization of CTNNB1 protein modified form]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA] CTD PMID:21554863 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1A1 protein
CTD PMID:15661813 PMID:15905203 PMID:16484233 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity
ISO 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1B1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1B1 protein
CTD PMID:15905203 PMID:16484233 PMID:16530937 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein] CTD PMID:21554863 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 protein] CTD PMID:21554863 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 protein] CTD PMID:21554863 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein modified form] CTD PMID:21554863 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 protein CTD PMID:21554863 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Wnt3a Wnt family member 3A multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of WNT3A protein] CTD PMID:21554863 NCBI chr10:44,034,174...44,078,463
Ensembl chr10:44,034,194...44,078,324
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      chemical role 19316
        antioxidant 14437
          chrysin 156
            6,8-di-(3,3-dimethylallyl)chrysin 0
            6-(3,3-dimethylallyl)chrysin 0
            6-geranylchrysin 0
            8-(3,3-dimethylallyl)chrysin 0
            8-geranylchrysin 0
            chrysin 5,7-dimethyl ether 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic molecule 19545
                              organic cyclic compound 19339
                                organic heterocyclic compound 18579
                                  oxacycle 17602
                                    benzopyran 11160
                                      1-benzopyran 10901
                                        flavonoid 6520
                                          flavones 4207
                                            hydroxyflavone 4195
                                              flavonols 4105
                                                7-hydroxyflavonol 4083
                                                  chrysin 156
                                                    6,8-di-(3,3-dimethylallyl)chrysin 0
                                                    6-(3,3-dimethylallyl)chrysin 0
                                                    6-geranylchrysin 0
                                                    8-(3,3-dimethylallyl)chrysin 0
                                                    8-geranylchrysin 0
                                                    chrysin 5,7-dimethyl ether 17
paths to the root