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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:75095
Term: chrysin
Definition: A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.
Chemical ID: MESH:C043561
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6multiple interactionsEXP 6480464CTDchrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein]; chrysin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; chrysin inhibits the reaction [Isoniazid results in increased expression of IL6 mRNA]; chrysin inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]PMID:23194824 PMID:30500344 PMID:33121995 PMID:37263553
Il6decreases expressionISOIL6 (Homo sapiens)6480464CTDchrysin results in decreased expression of IL6 mRNAPMID:20816778
Il6increases expressionISOIL6 (Homo sapiens)6480464CTDchrysin results in increased expression of IL6 mRNAPMID:18457675
Il6multiple interactionsISOIl6 (Mus musculus)6480464CTDchrysin inhibits the reaction [Oxidopamine results in increased expression of IL6 protein]PMID:29054324
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTDchrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL6 mRNA]; chrysin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]PMID:21515303 PMID:30016632
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