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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lipoic acid
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Accession:CHEBI:16494 term browser browse the term
Definition:A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
Synonyms:exact_synonym: 5-(1,2-dithiolan-3-yl)pentanoic acid
 related_synonym: 1,2-dithiolane-3-pentanoic acid;   1,2-dithiolane-3-valeric acid;   5-(1,2-dithiolan-3-yl)valeric acid;   5-(dithiolan-3-yl)valeric acid;   5-[3-(1,2-dithiolanyl)]pentanoic acid;   6,8-thioctic acid;   6,8-thiotic acid;   6-thioctic acid;   6-thiotic acid;   Acetate-replacing factor;   Biletan;   Formula=C8H14O2S2;   InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10);   InChIKey=AGBQKNBQESQNJD-UHFFFAOYSA-N;   SMILES=OC(=O)CCCCC1CCSS1;   Thioctansaeure;   Thioctic acid;   Thioctsaeure;   Thioktsaeure;   alpha-Liponsaeure;   alpha-lipoic acid;   liponic acid
 alt_id: CHEBI:146958;   CHEBI:25058;   CHEBI:6492
 xref: Beilstein:122410;   Beilstein:81853;   CAS:62-46-4;   DrugBank:DB00166;   Drug_Central:4732;   ECMDB:ECMDB01451;   Gmelin:720915;   KEGG:C00725;   KEGG:D00086
 xref_mesh: MESH:D008063
 xref: PMID:15328413;   PMID:7519986;   PMID:7548757;   Reaxys:81853;   Wikipedia:Lipoic_acid;   YMDB:YMDB00334
 cyclic_relationship: is_conjugate_acid_of CHEBI:30313


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lipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions EXP [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein CTD PMID:29128272 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Acadl acyl-Coenzyme A dehydrogenase, long-chain multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACADL mRNA] CTD PMID:22464149 NCBI chr 1:66,869,998...66,902,468
Ensembl chr 1:66,869,998...66,902,436 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions ISO
EXP		 Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE]
Thioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein]; Thioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA]		 CTD PMID:26518973 PMID:27260466 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP
ISO		 [Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein]
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of ACHE protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]		 CTD PMID:19669875 PMID:20663516 PMID:20730314 PMID:32911022 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:22464149 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO
EXP		 Thioctic Acid inhibits the reaction [Mitogens results in increased expression of ACTA2 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of ACTA2 protein]		 CTD PMID:21251946 PMID:24704557 PMID:29760339 PMID:34252510 PMID:35187969 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Ada adenosine deaminase multiple interactions ISO [Thioctic Acid co-treated with Valproic Acid] results in decreased activity of ADA protein CTD PMID:32662911 NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression		 ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
Thioctic Acid results in increased expression of ADIPOQ mRNA; Thioctic Acid results in increased expression of ADIPOQ protein		 CTD PMID:22664981 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Agt angiotensinogen multiple interactions EXP [Thioctic Acid co-treated with Dietary Fats] results in decreased expression of AGT mRNA CTD PMID:27260466 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP
ISO		 Thioctic Acid affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA]
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1]		 CTD PMID:26518973 PMID:27260466 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation
multiple interactions		 EXP Thioctic Acid results in decreased phosphorylation of AKT1 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of AKT1 mRNA]		 CTD PMID:21351249 PMID:27260466 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alad aminolevulinate, delta-, dehydratase multiple interactions ISO Thioctic Acid inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] CTD PMID:19798568 PMID:20026167 PMID:20584200 PMID:21783994 NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155 		JBrowse link
G Alb albumin multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ALB protein]
ALB protein results in increased uptake of [Thioctic Acid binds to Gold]		 CTD PMID:24704557 PMID:28433809 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Apln apelin multiple interactions
increases secretion
increases expression		 EXP acadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] CTD PMID:21461750 NCBI chr  X:47,114,023...47,123,730
Ensembl chr  X:47,114,023...47,123,730 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions EXP
ISO		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein]		 CTD PMID:23892647 PMID:30605698 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF6 mRNA] CTD PMID:23892647 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340 		JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide multiple interactions EXP Thioctic Acid inhibits the reaction [Silicon results in decreased expression of ATP1A2 mRNA] CTD PMID:34252510 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631 		JBrowse link
G Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide multiple interactions EXP Thioctic Acid affects the reaction [Dietary Fats affects the expression of ATP1B1 mRNA] CTD PMID:27260466 NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924 		JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 multiple interactions EXP Thioctic Acid promotes the reaction [Dietary Fats results in decreased expression of ATP2A2 mRNA] CTD PMID:27260466 NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO
EXP		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased localization of BAX protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BAX mRNA]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of BAX mRNA; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX protein]		 CTD PMID:15735709 PMID:23830814 PMID:23892647 PMID:27544635 PMID:30605698 More... NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BBC3 mRNA] CTD PMID:23892647 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP
ISO		 [Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]
Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of BCHE protein]		 CTD PMID:20663516 PMID:32911022 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases response to substance		 ISO
EXP		 Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]; Thioctic Acid results in increased degradation of and results in decreased expression of BCL2 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA]
Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 protein]
BCL2 protein results in decreased susceptibility to Thioctic Acid		 CTD PMID:16990509 PMID:21600978 PMID:23830814 PMID:27260466 PMID:27544635 More... NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of BCL2L1 mRNA CTD PMID:23830814 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Brca2 breast cancer 2, early onset multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of BRCA2 mRNA] CTD PMID:23608068 NCBI chr 5:150,445,759...150,493,612
Ensembl chr 5:150,446,095...150,493,794 		JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide decreases expression EXP Thioctic Acid results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 4:136,623,227...136,626,155
Ensembl chr 4:136,623,228...136,626,114 		JBrowse link
G C4b complement C4B (Chido blood group) decreases expression EXP Thioctic Acid results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr17:34,947,249...34,962,876
Ensembl chr17:34,947,354...34,962,856 		JBrowse link
G Calb2 calbindin 2 multiple interactions ISO Thioctic Acid affects the reaction [Propylthiouracil results in increased expression of CALB2 mRNA] CTD PMID:31068541 NCBI chr 8:110,869,158...110,894,844
Ensembl chr 8:110,864,134...110,894,842 		JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of CALM1 mRNA] CTD PMID:26165643 NCBI chr12:100,165,694...100,176,083
Ensembl chr12:100,165,694...100,176,073 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of CAMK2A protein] CTD PMID:37739047 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 EXP
ISO		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
Thioctic Acid results in increased expression of CASP3 protein modified form
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]
Thioctic Acid results in increased activity of CASP3 protein
[Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP3 protein modified form]; Thioctic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]		 CTD PMID:15909127 PMID:17079870 PMID:19951573 PMID:21062633 PMID:21763304 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]		 CTD PMID:23830814 PMID:27544635 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO Thioctic Acid results in increased activity of CASP9 protein
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CASP9 mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP9 protein modified form]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]		 CTD PMID:16990509 PMID:19951573 PMID:23830814 PMID:27544635 PMID:30605698 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions
increases expression
increases activity		 EXP
ISO		 Thioctic Acid inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of CAT mRNA]
Thioctic Acid results in increased expression of CAT mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of CAT mRNA
Thioctic Acid results in increased activity of CAT protein
[acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; Succimer promotes the reaction [Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Valproic Acid results in decreased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]]; Thioctic Acid promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]		 CTD PMID:15998567 PMID:19368863 PMID:19699728 PMID:19715735 PMID:21763304 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of CCL2 mRNA] CTD PMID:22488045 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein] CTD PMID:21600978 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]] CTD PMID:21315065 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cd86 CD86 antigen increases expression ISO Thioctic Acid results in increased expression of CD86 protein CTD PMID:19033392 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443 		JBrowse link
G Cd8a CD8 subunit alpha multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA CTD PMID:23830814 NCBI chr 6:71,350,411...71,356,155
Ensembl chr 6:71,350,411...71,356,157 		JBrowse link
G Cdx4 caudal type homeobox 4 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of CDX4 mRNA] CTD PMID:23608068 NCBI chr  X:102,365,004...102,373,830
Ensembl chr  X:102,365,004...102,374,198 		JBrowse link
G Chat choline acetyltransferase multiple interactions ISO [Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein CTD PMID:19669875 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946 		JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein] CTD PMID:19635391 NCBI chr19:12,740,892...12,742,996
Ensembl chr19:12,741,024...12,742,996 		JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO
EXP		 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of COL1A1 mRNA; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL1A1 mRNA]		 CTD PMID:21251946 PMID:23830814 PMID:34252510 PMID:35187969 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Col3a1 collagen, type III, alpha 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL3A1 mRNA] CTD PMID:34252510 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 multiple interactions EXP Thioctic Acid inhibits the reaction [Silicon results in decreased expression of COX4I1 mRNA] CTD PMID:34252510 NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:22464149 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein] CTD PMID:32061141 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crp C-reactive protein, pentraxin-related multiple interactions ISO Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein] CTD PMID:26276312 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cryaa crystallin, alpha A multiple interactions ISO Thioctic Acid inhibits the reaction [naphthalene results in increased cleavage of CRYAA protein] CTD PMID:20597648 NCBI chr17:31,896,905...31,900,704
Ensembl chr17:31,896,781...31,900,707 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of CTNNB1 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of CTNNB1 protein] CTD PMID:34133789 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Ctss cathepsin S decreases expression EXP Thioctic Acid results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO Thioctic Acid inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of CXCL8 mRNA] CTD PMID:30758914 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyba cytochrome b-245, alpha polypeptide multiple interactions EXP Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of CYBA mRNA] CTD PMID:35187969 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB] CTD PMID:26518973 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Thioctic Acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] CTD PMID:19951573 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] CTD PMID:21932800 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP
ISO		 [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]		 CTD PMID:21932800 PMID:24120545 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Thioctic Acid affects the reaction [cyanoginosin LR affects the expression of CYP2E1 protein] CTD PMID:32061150 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dab1 disabled 1 multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of DAB1 mRNA CTD PMID:31068541 NCBI chr 4:103,476,425...104,602,041
Ensembl chr 4:103,476,556...104,602,041 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP
ISO		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]		 CTD PMID:23892647 PMID:30605698 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA] CTD PMID:22464149 NCBI chr 7:98,802,870...98,831,920
Ensembl chr 7:98,802,865...98,831,926 		JBrowse link
G Dio1 deiodinase, iodothyronine, type I multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of DIO1 mRNA] CTD PMID:27260466 NCBI chr 4:107,148,662...107,164,365
Ensembl chr 4:107,148,662...107,164,366 		JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions ISO [5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] CTD PMID:21551353 NCBI chr12:31,381,561...31,401,470
Ensembl chr12:31,381,276...31,401,452 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of DLG4 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of DLG4 protein] CTD PMID:34133789 NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348 		JBrowse link
G Dnm1l dynamin 1-like decreases expression
multiple interactions		 EXP Thioctic Acid results in decreased expression of DNM1L mRNA
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L mRNA]; Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L protein]		 CTD PMID:37739047 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein] CTD PMID:20730801 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2A protein] CTD PMID:23892647 NCBI chr 3:58,433,252...58,464,922
Ensembl chr 3:58,433,242...58,464,922 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions ISO Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form] CTD PMID:30605698 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein] CTD PMID:27544635 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of FIS1 mRNA] CTD PMID:37739047 NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088 		JBrowse link
G Flt1 FMS-like tyrosine kinase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] CTD PMID:23608068 NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP		 Thioctic Acid inhibits the reaction [Diazinon results in decreased expression of FN1 protein]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]		 CTD PMID:32911022 PMID:35187969 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of FOS mRNA CTD PMID:31068541 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Foxo3 forkhead box O3 decreases acetylation
multiple interactions		 ISO Thioctic Acid results in decreased acetylation of FOXO3 protein
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein		 CTD PMID:22327056 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Fras1 Fraser extracellular matrix complex subunit 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FRAS1 mRNA] CTD PMID:23608068 NCBI chr 5:96,518,622...96,932,592
Ensembl chr 5:96,521,814...96,932,587 		JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of FSHB protein] CTD PMID:20957662 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G Fzd2 frizzled class receptor 2 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of FZD2 protein] CTD PMID:34133789 NCBI chr11:102,495,257...102,498,884
Ensembl chr11:102,495,222...102,498,884 		JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GAD1 mRNA CTD PMID:31068541 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO
EXP		 Thioctic Acid results in increased expression of GCLC mRNA
Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA]; Thioctic Acid results in increased expression of and results in increased activity of GCLC protein
Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein]		 CTD PMID:16249512 PMID:17940886 PMID:26365678 PMID:27298056 PMID:32061141 More... NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression
multiple interactions		 ISO Thioctic Acid results in increased expression of GCLM mRNA; Thioctic Acid results in increased expression of GCLM protein
Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM mRNA]; Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM protein]		 CTD PMID:16249512 PMID:26365678 PMID:32061141 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression EXP Thioctic Acid results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] CTD PMID:24704557 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO
EXP		 Thioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein]; Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA]
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]		 CTD PMID:26165643 PMID:27260466 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gls glutaminase multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GLS protein] CTD PMID:32061141 NCBI chr 1:52,202,608...52,274,168
Ensembl chr 1:52,202,607...52,272,391 		JBrowse link
G Gnrhr gonadotropin releasing hormone receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GNRHR mRNA] CTD PMID:28070105 NCBI chr 5:86,328,613...86,345,760
Ensembl chr 5:86,328,613...86,345,760 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO
EXP		 Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GPT protein]
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of GPT protein]		 CTD PMID:24704557 PMID:37739047 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions		 ISO Thioctic Acid results in increased expression of GPX1 mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GPX1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GPX1 mRNA]		 CTD PMID:23649336 PMID:32061141 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA CTD PMID:23830814 NCBI chr12:76,839,109...76,842,328
Ensembl chr12:76,839,107...76,842,273 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression
multiple interactions		 ISO Thioctic Acid results in increased expression of GPX3 mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of GPX3 mRNA		 CTD PMID:23649336 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression ISO Thioctic Acid results in increased expression of GPX5 mRNA CTD PMID:23649336 NCBI chr13:21,470,599...21,476,897
Ensembl chr13:21,470,599...21,476,901 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 protein] CTD PMID:32061141 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GRIN2A mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A protein] CTD PMID:31068541 PMID:32061141 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions		 EXP
ISO		 Thioctic Acid results in increased phosphorylation of GSK3B protein
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of GSK3B protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of GSK3B protein]
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]		 CTD PMID:19879292 PMID:27260466 PMID:34133789 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Gsr glutathione reductase multiple interactions
increases expression		 ISO Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of GSR protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein]
Thioctic Acid inhibits the reaction [cyanoginosin LR results in decreased activity of GSR protein]
Thioctic Acid results in increased expression of GSR mRNA		 CTD PMID:19699728 PMID:22623521 PMID:23649336 PMID:27581792 PMID:32061150 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gss glutathione synthetase multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of GSS protein] CTD PMID:32061141 NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions ISO
EXP		 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
[Dietary Fats co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA		 CTD PMID:18367378 PMID:23830814 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstm7 glutathione S-transferase, mu 7 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of GSTM7 mRNA] CTD PMID:23608068 NCBI chr 3:107,833,650...107,839,193
Ensembl chr 3:107,833,650...107,839,133 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions
increases expression		 ISO [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; Thioctic Acid results in increased expression of and results in increased activity of GSTP1 protein
Thioctic Acid results in increased expression of GSTP1 mRNA		 CTD PMID:20237067 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] CTD PMID:19699728 NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO [Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein CTD PMID:28433809 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO
EXP		 [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of HMOX1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 protein]
Thioctic Acid results in increased expression of HMOX1 mRNA; Thioctic Acid results in increased expression of HMOX1 protein
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of HMOX1 mRNA]		 CTD PMID:19033392 PMID:21315065 PMID:22488045 PMID:23649336 PMID:23942037 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hs1bp3 HCLS1 binding protein 3 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of HS1BP3 mRNA] CTD PMID:23608068 NCBI chr12:8,363,389...8,393,824
Ensembl chr12:8,363,432...8,393,824 		JBrowse link
G Hsd3b4 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of HSD3B4 mRNA] CTD PMID:23608068 NCBI chr 3:98,406,387...98,417,895
Ensembl chr 3:98,406,387...98,417,830 		JBrowse link
G Hspa1a heat shock protein 1A multiple interactions ISO Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA] CTD PMID:28880400 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions EXP
ISO		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HSPA5 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]		 CTD PMID:23892647 PMID:30605698 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA] CTD PMID:28880400 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of IL10]; Thioctic Acid promotes the reaction [Carrageenan results in increased expression of IL10 mRNA] CTD PMID:19735303 PMID:26518973 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of IL1A mRNA CTD PMID:31068541 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL1B mRNA; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL1B]		 CTD PMID:23830814 PMID:24975507 PMID:26518973 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL2 protein] CTD PMID:21195065 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il22ra2 interleukin 22 receptor, alpha 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of IL22RA2 mRNA] CTD PMID:23608068 NCBI chr10:19,497,776...19,510,429
Ensembl chr10:19,497,746...19,510,429 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL4 mRNA CTD PMID:23830814 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of IL6 mRNA]
[Thioctic Acid binds to Gold] which results in increased expression of IL6 protein
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL6]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]]		 CTD PMID:22488045 PMID:26518973 PMID:28433809 PMID:29233029 PMID:29760339 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions ISO acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased secretion of INS1 protein]] CTD PMID:21461750 PMID:29760339 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II multiple interactions ISO Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Thioctic Acid results in increased sumoylation of and results in decreased activity of IRF1 protein CTD PMID:24975507 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200 		JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
increases activity		 ISO [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]
Thioctic Acid results in increased expression of JUN protein
Thioctic Acid results in increased activity of JUN protein		 CTD PMID:20237067 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 increases expression
multiple interactions		 ISO
EXP		 Thioctic Acid results in increased expression of KEAP1 protein
Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein]		 CTD PMID:19033392 PMID:34252510 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions ISO Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased expression of LDHC protein] CTD PMID:21195065 PMID:27581792 NCBI chr 7:46,510,687...46,527,571
Ensembl chr 7:46,510,627...46,527,566 		JBrowse link
G Lep leptin decreases secretion
decreases expression		 EXP
ISO		 Thioctic Acid results in decreased secretion of LEP protein
Thioctic Acid results in decreased expression of LEP mRNA; Thioctic Acid results in decreased expression of LEP protein		 CTD PMID:21351249 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lhb luteinizing hormone beta multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of LHB protein]; Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LHB mRNA] CTD PMID:20957662 PMID:28070105 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321 		JBrowse link
G Lipe lipase, hormone sensitive multiple interactions
increases phosphorylation		 EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein] CTD PMID:22941773 NCBI chr 7:25,078,952...25,097,911
Ensembl chr 7:25,078,952...25,098,135 		JBrowse link
G Lyz1 lysozyme 1 decreases expression EXP Thioctic Acid results in decreased expression of LYZ1 mRNA CTD PMID:19555370 NCBI chr10:117,123,700...117,128,773
Ensembl chr10:117,123,702...117,128,773 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 affects activity
multiple interactions		 ISO Thioctic Acid affects the activity of MAPK1 protein
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK1 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK1 protein]		 CTD PMID:15909127 PMID:21251946 PMID:32061141 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK14 mRNA CTD PMID:23830814 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK3 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK3 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK3 protein] CTD PMID:21251946 PMID:23830814 PMID:32061141 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK8 mRNA CTD PMID:23830814 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of MAPT protein] CTD PMID:34133789 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Mff mitochondrial fission factor decreases expression
multiple interactions		 EXP Thioctic Acid results in decreased expression of MFF mRNA
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFF mRNA]		 CTD PMID:37739047 NCBI chr 1:82,702,599...82,730,111
Ensembl chr 1:82,702,611...82,730,115 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFN2 mRNA] CTD PMID:37739047 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mir210 microRNA 210 multiple interactions ISO [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]] CTD PMID:26276312 NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406 		JBrowse link
G Mir21a microRNA 21a multiple interactions ISO Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA] CTD PMID:26276312 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA CTD PMID:23830814 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA]		 CTD PMID:24975507 PMID:29233029 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of MMP2 mRNA CTD PMID:23830814 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] CTD PMID:24975507 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]] CTD PMID:21315065 NCBI chr 8:39,996,284...40,095,790
Ensembl chr 8:40,034,726...40,095,714 		JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MT1 mRNA CTD PMID:18367378 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Mvd mevalonate (diphospho) decarboxylase multiple interactions EXP [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MVD mRNA CTD PMID:18367378 NCBI chr 8:123,160,335...123,170,161
Ensembl chr 8:123,160,340...123,170,161 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein] CTD PMID:21600978 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of NCF1] CTD PMID:26518973 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
affects localization
increases expression
increases activity
decreases expression		 ISO
EXP		 [Paraquat co-treated with Thioctic Acid] results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NFE2L2 mRNA]; Thioctic Acid promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thioctic Acid results in increased expression of and affects the localization of NFE2L2 protein
Thioctic Acid affects the localization of NFE2L2 protein
Thioctic Acid results in increased expression of NFE2L2 mRNA; Thioctic Acid results in increased expression of NFE2L2 protein
Thioctic Acid results in increased activity of NFE2L2 protein
[Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]
Thioctic Acid results in decreased expression of NFE2L2 mRNA; Thioctic Acid results in decreased expression of NFE2L2 protein
[Thioctic Acid co-treated with cyanoginosin LR] results in increased expression of NFE2L2 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of NFE2L2 protein]		 CTD PMID:17197552 PMID:18258206 PMID:20237067 PMID:22488045 PMID:23649336 More... NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]
[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA		 CTD PMID:21600978 PMID:31068541 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of NFKBIA protein] CTD PMID:34133789 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO		 Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of NOS2]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]		 CTD PMID:15453632 PMID:21763304 PMID:29233029 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] CTD PMID:27260466 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]] CTD PMID:29760339 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO
EXP		 acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA]		 CTD PMID:29760339 PMID:35187969 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases activity
increases expression
multiple interactions		 ISO Thioctic Acid results in increased activity of NQO1 protein
Thioctic Acid results in increased expression of NQO1 mRNA; Thioctic Acid results in increased expression of NQO1 protein
[Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]		 CTD PMID:12180195 PMID:17940886 PMID:19033392 PMID:23649336 PMID:23830814 More... NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of OPA1 mRNA] CTD PMID:37739047 NCBI chr16:29,398,099...29,481,924
Ensembl chr16:29,398,152...29,473,702 		JBrowse link
G Otx2 orthodenticle homeobox 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA] CTD PMID:31068541 NCBI chr14:48,894,238...48,905,101
Ensembl chr14:48,895,134...48,911,276 		JBrowse link
G Pah phenylalanine hydroxylase decreases expression EXP Thioctic Acid results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998 		JBrowse link
G Pcdhb13 protocadherin beta 13 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of PCDHB6 mRNA] CTD PMID:23608068 NCBI chr18:37,575,570...37,579,262
Ensembl chr18:37,575,553...37,579,262 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of PCNA protein] CTD PMID:21251946 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PINK1 mRNA] CTD PMID:37739047 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618 		JBrowse link
G Plaat3 phospholipase A and acyltransferase 3 decreases activity
decreases expression		 EXP Thioctic Acid results in decreased activity of PLAAT3 protein
Thioctic Acid results in decreased expression of PLAAT3 mRNA		 CTD PMID:22941773 NCBI chr19:7,534,824...7,565,914
Ensembl chr19:7,534,824...7,565,910 		JBrowse link
G Plin1 perilipin 1 increases phosphorylation EXP Thioctic Acid results in increased phosphorylation of PLIN1 protein CTD PMID:22941773 NCBI chr 7:79,370,912...79,382,652
Ensembl chr 7:79,369,966...79,382,651 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity		 EXP
ISO		 [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; [Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]		 CTD PMID:16391466 PMID:21932800 PMID:24120545 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA] CTD PMID:22464149 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO [Thioctic Acid co-treated with Dietary Fats] results in increased expression of PPARG mRNA CTD PMID:22464149 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions
decreases expression
increases expression		 ISO
EXP		 [Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein
Thioctic Acid results in decreased expression of PPARGC1A protein
[Thioctic Acid co-treated with Silicon] results in increased expression of PPARGC1A protein; Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of PPARGC1A mRNA]
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]
Thioctic Acid results in increased expression of PPARGC1A protein		 CTD PMID:20414966 PMID:22464149 PMID:34252510 PMID:37739047 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta multiple interactions
decreases acetylation		 ISO [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]
Thioctic Acid results in decreased acetylation of PPARGC1B protein		 CTD PMID:22327056 PMID:22464149 NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502 		JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRDX3 mRNA] CTD PMID:37739047 NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit multiple interactions EXP [Thioctic Acid co-treated with Silicon] results in increased expression of PRKAA2 mRNA CTD PMID:34252510 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRKN mRNA] CTD PMID:37739047 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of PSEN1 protein] CTD PMID:34133789 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]]; Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]] CTD PMID:19735303 PMID:23830814 PMID:26276312 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
decreases phosphorylation		 EXP
ISO		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of RELA protein]
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of RELA protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA]
Thioctic Acid results in decreased phosphorylation of RELA protein		 CTD PMID:22488045 PMID:29233029 PMID:34133789 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Reln reelin multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of RELN mRNA CTD PMID:31068541 NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700 		JBrowse link
G S100b S100 protein, beta polypeptide, neural multiple interactions ISO [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein] CTD PMID:23880158 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993 		JBrowse link
G Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SEMA5A mRNA] CTD PMID:23608068 NCBI chr15:32,244,959...32,696,487
Ensembl chr15:32,244,956...32,696,487 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Silicon results in increased expression of SERPINE1 protein] CTD PMID:34252510 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA] CTD PMID:24704557 NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446 		JBrowse link
G Sftpa1 surfactant associated protein A1 multiple interactions ISO Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPA1 mRNA] CTD PMID:25215149 NCBI chr14:40,853,745...40,858,330
Ensembl chr14:40,853,739...40,858,409 		JBrowse link
G Sftpb surfactant associated protein B multiple interactions ISO Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPB mRNA] CTD PMID:25215149 NCBI chr 6:72,281,594...72,291,354
Ensembl chr 6:72,281,594...72,291,354 		JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions		 ISO
EXP		 Thioctic Acid results in increased expression of SIRT1 protein
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT1 mRNA]
Thioctic Acid results in increased expression of SIRT1 mRNA
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA]		 CTD PMID:22327056 PMID:37739047 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression		 ISO
EXP		 [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 mRNA]
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA]
Thioctic Acid results in increased expression of SIRT3 protein		 CTD PMID:22327056 PMID:37739047 NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222 		JBrowse link
G Slc12a2 solute carrier family 12, member 2 multiple interactions
affects activity		 ISO [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia]
Thioctic Acid affects the activity of SLC12A2 protein		 CTD PMID:23880158 NCBI chr18:58,011,505...58,079,893
Ensembl chr18:58,011,750...58,079,893 		JBrowse link
G Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC1A1 mRNA] CTD PMID:32061141 NCBI chr19:28,812,535...28,891,360
Ensembl chr19:28,812,449...28,891,360 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] CTD PMID:23892647 NCBI chr15:96,585,267...96,597,609
Ensembl chr15:96,585,273...96,597,611 		JBrowse link
G Slc5a6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 increases transport
multiple interactions		 ISO SLC5A6 results in increased transport of Thioctic Acid
Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
Sodium affects the reaction [SLC5A6 results in increased transport of Thioctic Acid]		 CTD PMID:9516450 PMID:10329687 NCBI chr 5:31,193,380...31,206,268
Ensembl chr 5:31,193,380...31,206,268 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC7A11 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC7A11 mRNA] CTD PMID:32061141 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:35187969 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:35187969 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Snca synuclein, alpha multiple interactions ISO [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of SOD1] CTD PMID:15804455 PMID:26518973 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
increases activity		 ISO
EXP		 Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein]
[Thioctic Acid co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of SOD2 mRNA]
Thioctic Acid results in increased activity of SOD2 protein		 CTD PMID:15804455 PMID:19951573 PMID:22327056 PMID:27260466 PMID:34252510 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions EXP Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein CTD PMID:21351249 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:22464149 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA] CTD PMID:28070105 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Thioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein] CTD PMID:19635391 PMID:28086195 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT3 protein] CTD PMID:19635391 PMID:28086195 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions EXP [Thioctic Acid co-treated with Silicon] results in increased expression of STK11 mRNA CTD PMID:34252510 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 increases expression ISO Thioctic Acid results in increased expression of SUMO1 protein CTD PMID:24975507 NCBI chr 1:59,678,593...59,709,993
Ensembl chr 1:59,625,717...59,709,993 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP Thioctic Acid inhibits the reaction [Silicon results in decreased expression of TFAM mRNA] CTD PMID:34252510 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFA mRNA] CTD PMID:29233029 NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP		 Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of TGFB1 protein]		 CTD PMID:15309289 PMID:21251946 PMID:24704557 PMID:26276312 PMID:29760339 More... NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TGFB1I1 mRNA] CTD PMID:23608068 NCBI chr 7:127,845,963...127,852,884
Ensembl chr 7:127,845,984...127,854,871 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA; [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of TGFB2 mRNA CTD PMID:23830814 PMID:31068541 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of THRA mRNA] CTD PMID:27260466 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TNF mRNA; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]]; Thioctic Acid affects the reaction [Paraquat affects the expression of TNF protein]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]		 CTD PMID:15309289 PMID:23830814 PMID:25215149 PMID:26276312 PMID:29233029 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b multiple interactions EXP
ISO		 Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TNFRSF10B mRNA]
Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TNFRSF10B mRNA]		 CTD PMID:23608068 PMID:23830814 NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860 		JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of TNFSF10 mRNA CTD PMID:23830814 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576 		JBrowse link
G Tnni3 troponin I, cardiac 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions EXP Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of TRIB3 mRNA]; Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of TRIB3 mRNA] CTD PMID:23608068 PMID:23892647 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Thioctic Acid inhibits the reaction [Methotrexate results in increased expression of TP53 protein] CTD PMID:19900424 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of TXN1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA] CTD PMID:23830814 PMID:31068541 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases reduction
multiple interactions		 ISO TXNRD1 protein results in increased reduction of Thioctic Acid
Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]		 CTD PMID:20810785 PMID:21172426 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA] CTD PMID:22327056 PMID:22464149 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO
EXP		 Cyclosporine inhibits the reaction [Thioctic Acid results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased expression of VEGFA mRNA]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of VEGFA mRNA]		 CTD PMID:11596663 PMID:22488045 PMID:26276312 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Wnt5a wingless-type MMTV integration site family, member 5A multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of WNT5A protein] CTD PMID:37739047 NCBI chr14:28,224,962...28,249,405
Ensembl chr14:28,226,707...28,249,405 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO Thioctic Acid inhibits the reaction [Valproic Acid results in increased activity of XDH protein] CTD PMID:32662911 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
(R)-lipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions EXP [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein CTD PMID:29128272 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Acadl acyl-Coenzyme A dehydrogenase, long-chain multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACADL mRNA] CTD PMID:22464149 NCBI chr 1:66,869,998...66,902,468
Ensembl chr 1:66,869,998...66,902,436 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions ISO
EXP		 Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE]
Thioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein]; Thioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA]		 CTD PMID:26518973 PMID:27260466 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP
ISO		 [Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein]
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of ACHE protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]		 CTD PMID:19669875 PMID:20663516 PMID:20730314 PMID:32911022 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:22464149 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO
EXP		 Thioctic Acid inhibits the reaction [Mitogens results in increased expression of ACTA2 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of ACTA2 protein]		 CTD PMID:21251946 PMID:24704557 PMID:29760339 PMID:34252510 PMID:35187969 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Ada adenosine deaminase multiple interactions ISO [Thioctic Acid co-treated with Valproic Acid] results in decreased activity of ADA protein CTD PMID:32662911 NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression		 ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
Thioctic Acid results in increased expression of ADIPOQ mRNA; Thioctic Acid results in increased expression of ADIPOQ protein		 CTD PMID:22664981 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Agt angiotensinogen multiple interactions EXP [Thioctic Acid co-treated with Dietary Fats] results in decreased expression of AGT mRNA CTD PMID:27260466 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP
ISO		 Thioctic Acid affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA]
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1]		 CTD PMID:26518973 PMID:27260466 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 decreases phosphorylation
multiple interactions		 EXP Thioctic Acid results in decreased phosphorylation of AKT1 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of AKT1 mRNA]		 CTD PMID:21351249 PMID:27260466 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alad aminolevulinate, delta-, dehydratase multiple interactions ISO Thioctic Acid inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] CTD PMID:19798568 PMID:20026167 PMID:20584200 PMID:21783994 NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155 		JBrowse link
G Alb albumin multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ALB protein]
ALB protein results in increased uptake of [Thioctic Acid binds to Gold]		 CTD PMID:24704557 PMID:28433809 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Apln apelin multiple interactions
increases expression
increases secretion		 EXP acadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] CTD PMID:21461750 NCBI chr  X:47,114,023...47,123,730
Ensembl chr  X:47,114,023...47,123,730 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions EXP
ISO		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein]		 CTD PMID:23892647 PMID:30605698 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF6 mRNA] CTD PMID:23892647 NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340 		JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide multiple interactions EXP Thioctic Acid inhibits the reaction [Silicon results in decreased expression of ATP1A2 mRNA] CTD PMID:34252510 NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631 		JBrowse link
G Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide multiple interactions EXP Thioctic Acid affects the reaction [Dietary Fats affects the expression of ATP1B1 mRNA] CTD PMID:27260466 NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924 		JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 multiple interactions EXP Thioctic Acid promotes the reaction [Dietary Fats results in decreased expression of ATP2A2 mRNA] CTD PMID:27260466 NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO
EXP		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased localization of BAX protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of BAX mRNA; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX protein]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BAX mRNA]		 CTD PMID:15735709 PMID:23830814 PMID:23892647 PMID:27544635 PMID:30605698 More... NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BBC3 mRNA] CTD PMID:23892647 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP
ISO		 [Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]
Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of BCHE protein]		 CTD PMID:20663516 PMID:32911022 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases response to substance		 ISO
EXP		 Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]; Thioctic Acid results in increased degradation of and results in decreased expression of BCL2 protein
BCL2 protein results in decreased susceptibility to Thioctic Acid
Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 protein]
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA]		 CTD PMID:16990509 PMID:21600978 PMID:23830814 PMID:27260466 PMID:27544635 More... NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of BCL2L1 mRNA CTD PMID:23830814 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Brca2 breast cancer 2, early onset multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of BRCA2 mRNA] CTD PMID:23608068 NCBI chr 5:150,445,759...150,493,612
Ensembl chr 5:150,446,095...150,493,794 		JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide decreases expression EXP Thioctic Acid results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 4:136,623,227...136,626,155
Ensembl chr 4:136,623,228...136,626,114 		JBrowse link
G C4b complement C4B (Chido blood group) decreases expression EXP Thioctic Acid results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr17:34,947,249...34,962,876
Ensembl chr17:34,947,354...34,962,856 		JBrowse link
G Calb2 calbindin 2 multiple interactions ISO Thioctic Acid affects the reaction [Propylthiouracil results in increased expression of CALB2 mRNA] CTD PMID:31068541 NCBI chr 8:110,869,158...110,894,844
Ensembl chr 8:110,864,134...110,894,842 		JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of CALM1 mRNA] CTD PMID:26165643 NCBI chr12:100,165,694...100,176,083
Ensembl chr12:100,165,694...100,176,073 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of CAMK2A protein] CTD PMID:37739047 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression		 EXP
ISO		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
[Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP3 protein modified form]; Thioctic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]
Thioctic Acid results in increased activity of CASP3 protein
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]
Thioctic Acid results in increased expression of CASP3 protein modified form		 CTD PMID:15909127 PMID:17079870 PMID:19951573 PMID:21062633 PMID:21763304 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]		 CTD PMID:23830814 PMID:27544635 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO Thioctic Acid results in increased activity of CASP9 protein
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CASP9 mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP9 protein modified form]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]		 CTD PMID:16990509 PMID:19951573 PMID:23830814 PMID:27544635 PMID:30605698 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression		 EXP
ISO		 Thioctic Acid inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of CAT mRNA]
[acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; Succimer promotes the reaction [Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Valproic Acid results in decreased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]]; Thioctic Acid promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]
Thioctic Acid results in increased activity of CAT protein
[Paraquat co-treated with Thioctic Acid] results in increased expression of CAT mRNA
Thioctic Acid results in increased expression of CAT mRNA		 CTD PMID:15998567 PMID:19368863 PMID:19699728 PMID:19715735 PMID:21763304 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of CCL2 mRNA] CTD PMID:22488045 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein] CTD PMID:21600978 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]] CTD PMID:21315065 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cd86 CD86 antigen increases expression ISO Thioctic Acid results in increased expression of CD86 protein CTD PMID:19033392 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443 		JBrowse link
G Cd8a CD8 subunit alpha multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA CTD PMID:23830814 NCBI chr 6:71,350,411...71,356,155
Ensembl chr 6:71,350,411...71,356,157 		JBrowse link
G Cdx4 caudal type homeobox 4 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of CDX4 mRNA] CTD PMID:23608068 NCBI chr  X:102,365,004...102,373,830
Ensembl chr  X:102,365,004...102,374,198 		JBrowse link
G Chat choline acetyltransferase multiple interactions ISO [Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein CTD PMID:19669875 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946 		JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein] CTD PMID:19635391 NCBI chr19:12,740,892...12,742,996
Ensembl chr19:12,741,024...12,742,996 		JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO
EXP		 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of COL1A1 mRNA; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL1A1 mRNA]		 CTD PMID:21251946 PMID:23830814 PMID:34252510 PMID:35187969 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Col3a1 collagen, type III, alpha 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL3A1 mRNA] CTD PMID:34252510 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 multiple interactions EXP Thioctic Acid inhibits the reaction [Silicon results in decreased expression of COX4I1 mRNA] CTD PMID:34252510 NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:22464149 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein] CTD PMID:32061141 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crp C-reactive protein, pentraxin-related multiple interactions ISO Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein] CTD PMID:26276312 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cryaa crystallin, alpha A multiple interactions ISO Thioctic Acid inhibits the reaction [naphthalene results in increased cleavage of CRYAA protein] CTD PMID:20597648 NCBI chr17:31,896,905...31,900,704
Ensembl chr17:31,896,781...31,900,707 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of CTNNB1 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of CTNNB1 protein] CTD PMID:34133789 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Ctss cathepsin S decreases expression EXP Thioctic Acid results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO Thioctic Acid inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of CXCL8 mRNA] CTD PMID:30758914 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyba cytochrome b-245, alpha polypeptide multiple interactions EXP Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of CYBA mRNA] CTD PMID:35187969 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB] CTD PMID:26518973 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Thioctic Acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] CTD PMID:19951573 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] CTD PMID:21932800 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP
ISO		 [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]		 CTD PMID:21932800 PMID:24120545 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions ISO Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Thioctic Acid affects the reaction [cyanoginosin LR affects the expression of CYP2E1 protein] CTD PMID:32061150 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dab1 disabled 1 multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of DAB1 mRNA CTD PMID:31068541 NCBI chr 4:103,476,425...104,602,041
Ensembl chr 4:103,476,556...104,602,041 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP
ISO		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]		 CTD PMID:23892647 PMID:30605698 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA] CTD PMID:22464149 NCBI chr 7:98,802,870...98,831,920
Ensembl chr 7:98,802,865...98,831,926 		JBrowse link
G Dio1 deiodinase, iodothyronine, type I multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of DIO1 mRNA] CTD PMID:27260466 NCBI chr 4:107,148,662...107,164,365
Ensembl chr 4:107,148,662...107,164,366 		JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions ISO [5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] CTD PMID:21551353 NCBI chr12:31,381,561...31,401,470
Ensembl chr12:31,381,276...31,401,452 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of DLG4 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of DLG4 protein] CTD PMID:34133789 NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348 		JBrowse link
G Dnm1l dynamin 1-like decreases expression
multiple interactions		 EXP Thioctic Acid results in decreased expression of DNM1L mRNA
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L mRNA]; Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L protein]		 CTD PMID:37739047 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein] CTD PMID:20730801 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2A protein] CTD PMID:23892647 NCBI chr 3:58,433,252...58,464,922
Ensembl chr 3:58,433,242...58,464,922 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions ISO Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form] CTD PMID:30605698 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein] CTD PMID:27544635 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of FIS1 mRNA] CTD PMID:37739047 NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088 		JBrowse link
G Flt1 FMS-like tyrosine kinase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] CTD PMID:23608068 NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP		 Thioctic Acid inhibits the reaction [Diazinon results in decreased expression of FN1 protein]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]		 CTD PMID:32911022 PMID:35187969 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of FOS mRNA CTD PMID:31068541 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Foxo3 forkhead box O3 decreases acetylation
multiple interactions		 ISO Thioctic Acid results in decreased acetylation of FOXO3 protein
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein		 CTD PMID:22327056 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Fras1 Fraser extracellular matrix complex subunit 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FRAS1 mRNA] CTD PMID:23608068 NCBI chr 5:96,518,622...96,932,592
Ensembl chr 5:96,521,814...96,932,587 		JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of FSHB protein] CTD PMID:20957662 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G Fzd2 frizzled class receptor 2 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of FZD2 protein] CTD PMID:34133789 NCBI chr11:102,495,257...102,498,884
Ensembl chr11:102,495,222...102,498,884 		JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GAD1 mRNA CTD PMID:31068541 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO
EXP		 Thioctic Acid results in increased expression of GCLC mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein]
Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein]
Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA]; Thioctic Acid results in increased expression of and results in increased activity of GCLC protein		 CTD PMID:16249512 PMID:17940886 PMID:26365678 PMID:27298056 PMID:32061141 More... NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression
multiple interactions		 ISO Thioctic Acid results in increased expression of GCLM mRNA; Thioctic Acid results in increased expression of GCLM protein
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM protein]
Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM mRNA]; Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM protein]		 CTD PMID:16249512 PMID:26365678 PMID:32061141 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression EXP Thioctic Acid results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] CTD PMID:24704557 NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO
EXP		 Thioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein]; Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA]
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]		 CTD PMID:26165643 PMID:27260466 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gls glutaminase multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GLS protein] CTD PMID:32061141 NCBI chr 1:52,202,608...52,274,168
Ensembl chr 1:52,202,607...52,272,391 		JBrowse link
G Gnrhr gonadotropin releasing hormone receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GNRHR mRNA] CTD PMID:28070105 NCBI chr 5:86,328,613...86,345,760
Ensembl chr 5:86,328,613...86,345,760 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO
EXP		 Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GPT protein]
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of GPT protein]		 CTD PMID:24704557 PMID:37739047 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions		 ISO Thioctic Acid results in increased expression of GPX1 mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GPX1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GPX1 mRNA]		 CTD PMID:23649336 PMID:32061141 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA CTD PMID:23830814 NCBI chr12:76,839,109...76,842,328
Ensembl chr12:76,839,107...76,842,273 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression
multiple interactions		 ISO Thioctic Acid results in increased expression of GPX3 mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of GPX3 mRNA		 CTD PMID:23649336 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Gpx5 glutathione peroxidase 5 increases expression ISO Thioctic Acid results in increased expression of GPX5 mRNA CTD PMID:23649336 NCBI chr13:21,470,599...21,476,897
Ensembl chr13:21,470,599...21,476,901 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 protein] CTD PMID:32061141 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GRIN2A mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A protein] CTD PMID:31068541 PMID:32061141 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions		 EXP
ISO		 Thioctic Acid results in increased phosphorylation of GSK3B protein
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of GSK3B protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of GSK3B protein]		 CTD PMID:19879292 PMID:27260466 PMID:34133789 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Gsr glutathione reductase multiple interactions
increases expression		 ISO Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of GSR protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein]
Thioctic Acid results in increased expression of GSR mRNA
Thioctic Acid inhibits the reaction [cyanoginosin LR results in decreased activity of GSR protein]		 CTD PMID:19699728 PMID:22623521 PMID:23649336 PMID:27581792 PMID:32061150 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gss glutathione synthetase multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of GSS protein] CTD PMID:32061141 NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions ISO
EXP		 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
[Dietary Fats co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA		 CTD PMID:18367378 PMID:23830814 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289 		JBrowse link
G Gstm7 glutathione S-transferase, mu 7 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of GSTM7 mRNA] CTD PMID:23608068 NCBI chr 3:107,833,650...107,839,193
Ensembl chr 3:107,833,650...107,839,133 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions
increases expression		 ISO [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; Thioctic Acid results in increased expression of and results in increased activity of GSTP1 protein
Thioctic Acid results in increased expression of GSTP1 mRNA		 CTD PMID:20237067 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] CTD PMID:19699728 NCBI chr 5:130,011,278...130,031,890
Ensembl chr 5:130,017,852...130,031,890 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO [Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein CTD PMID:28433809 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO
EXP		 [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of HMOX1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]
Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of HMOX1 mRNA]
Thioctic Acid results in increased expression of HMOX1 protein
Thioctic Acid results in increased expression of HMOX1 mRNA; Thioctic Acid results in increased expression of HMOX1 protein
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 protein]		 CTD PMID:19033392 PMID:21315065 PMID:22488045 PMID:23649336 PMID:23942037 More... NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hs1bp3 HCLS1 binding protein 3 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of HS1BP3 mRNA] CTD PMID:23608068 NCBI chr12:8,363,389...8,393,824
Ensembl chr12:8,363,432...8,393,824 		JBrowse link
G Hsd3b4 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of HSD3B4 mRNA] CTD PMID:23608068 NCBI chr 3:98,406,387...98,417,895
Ensembl chr 3:98,406,387...98,417,830 		JBrowse link
G Hspa1a heat shock protein 1A multiple interactions ISO Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA] CTD PMID:28880400 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions EXP
ISO		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HSPA5 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]		 CTD PMID:23892647 PMID:30605698 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA] CTD PMID:28880400 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of IL10]; Thioctic Acid promotes the reaction [Carrageenan results in increased expression of IL10 mRNA] CTD PMID:19735303 PMID:26518973 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of IL1A mRNA CTD PMID:31068541 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL1B mRNA; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL1B]
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]		 CTD PMID:23830814 PMID:24975507 PMID:26518973 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL2 protein] CTD PMID:21195065 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il22ra2 interleukin 22 receptor, alpha 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of IL22RA2 mRNA] CTD PMID:23608068 NCBI chr10:19,497,776...19,510,429
Ensembl chr10:19,497,746...19,510,429 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL4 mRNA CTD PMID:23830814 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of IL6 mRNA]
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL6]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]]
[Thioctic Acid binds to Gold] which results in increased expression of IL6 protein		 CTD PMID:22488045 PMID:26518973 PMID:28433809 PMID:29233029 PMID:29760339 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I multiple interactions ISO acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased secretion of INS1 protein]] CTD PMID:21461750 PMID:29760339 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II multiple interactions ISO Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Thioctic Acid results in increased sumoylation of and results in decreased activity of IRF1 protein CTD PMID:24975507 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200 		JBrowse link
G Jun jun proto-oncogene multiple interactions
increases activity
increases expression		 ISO [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]
Thioctic Acid results in increased activity of JUN protein
Thioctic Acid results in increased expression of JUN protein		 CTD PMID:20237067 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 increases expression
multiple interactions		 ISO
EXP		 Thioctic Acid results in increased expression of KEAP1 protein
Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein]		 CTD PMID:19033392 PMID:34252510 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions ISO Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased expression of LDHC protein] CTD PMID:21195065 PMID:27581792 NCBI chr 7:46,510,687...46,527,571
Ensembl chr 7:46,510,627...46,527,566 		JBrowse link
G Lep leptin decreases secretion
decreases expression		 EXP
ISO		 Thioctic Acid results in decreased secretion of LEP protein
Thioctic Acid results in decreased expression of LEP mRNA
Thioctic Acid results in decreased expression of LEP mRNA; Thioctic Acid results in decreased expression of LEP protein		 CTD PMID:21351249 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lhb luteinizing hormone beta multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of LHB protein]; Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LHB mRNA] CTD PMID:20957662 PMID:28070105 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321 		JBrowse link
G Lipe lipase, hormone sensitive multiple interactions
increases phosphorylation		 EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein] CTD PMID:22941773 NCBI chr 7:25,078,952...25,097,911
Ensembl chr 7:25,078,952...25,098,135 		JBrowse link
G Lyz1 lysozyme 1 decreases expression EXP Thioctic Acid results in decreased expression of LYZ1 mRNA CTD PMID:19555370 NCBI chr10:117,123,700...117,128,773
Ensembl chr10:117,123,702...117,128,773 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 affects activity
multiple interactions		 ISO Thioctic Acid affects the activity of MAPK1 protein
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK1 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK1 protein]		 CTD PMID:15909127 PMID:21251946 PMID:32061141 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK14 mRNA CTD PMID:23830814 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK3 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK3 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK3 protein] CTD PMID:21251946 PMID:23830814 PMID:32061141 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK8 mRNA CTD PMID:23830814 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of MAPT protein] CTD PMID:34133789 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Mff mitochondrial fission factor decreases expression
multiple interactions		 EXP Thioctic Acid results in decreased expression of MFF mRNA
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFF mRNA]		 CTD PMID:37739047 NCBI chr 1:82,702,599...82,730,111
Ensembl chr 1:82,702,611...82,730,115 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFN2 mRNA] CTD PMID:37739047 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mir210 microRNA 210 multiple interactions ISO [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]] CTD PMID:26276312 NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406 		JBrowse link
G Mir21a microRNA 21a multiple interactions ISO Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA] CTD PMID:26276312 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA CTD PMID:23830814 NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA]		 CTD PMID:24975507 PMID:29233029 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of MMP2 mRNA CTD PMID:23830814 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] CTD PMID:24975507 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]] CTD PMID:21315065 NCBI chr 8:39,996,284...40,095,790
Ensembl chr 8:40,034,726...40,095,714 		JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MT1 mRNA CTD PMID:18367378 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Mvd mevalonate (diphospho) decarboxylase multiple interactions EXP [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MVD mRNA CTD PMID:18367378 NCBI chr 8:123,160,335...123,170,161
Ensembl chr 8:123,160,340...123,170,161 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein] CTD PMID:21600978 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of NCF1] CTD PMID:26518973 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions
decreases expression
increases expression
increases activity
affects localization		 ISO
EXP		 [Paraquat co-treated with Thioctic Acid] results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NFE2L2 mRNA]; Thioctic Acid promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thioctic Acid results in increased expression of and affects the localization of NFE2L2 protein
[Thioctic Acid co-treated with cyanoginosin LR] results in increased expression of NFE2L2 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of NFE2L2 protein]
Thioctic Acid results in decreased expression of NFE2L2 mRNA; Thioctic Acid results in decreased expression of NFE2L2 protein
[Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]
Thioctic Acid results in increased expression of NFE2L2 protein
Thioctic Acid results in increased activity of NFE2L2 protein
Thioctic Acid results in increased expression of NFE2L2 mRNA; Thioctic Acid results in increased expression of NFE2L2 protein
Thioctic Acid affects the localization of NFE2L2 protein		 CTD PMID:17197552 PMID:18258206 PMID:20237067 PMID:22488045 PMID:23649336 More... NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]
[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA		 CTD PMID:21600978 PMID:31068541 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of NFKBIA protein] CTD PMID:34133789 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO		 Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of NOS2]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]		 CTD PMID:15453632 PMID:21763304 PMID:29233029 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] CTD PMID:27260466 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]] CTD PMID:29760339 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO
EXP		 acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA]		 CTD PMID:29760339 PMID:35187969 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases activity
increases expression
multiple interactions		 ISO Thioctic Acid results in increased activity of NQO1 protein
Thioctic Acid results in increased expression of NQO1 mRNA; Thioctic Acid results in increased expression of NQO1 protein
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]
[Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein]		 CTD PMID:12180195 PMID:17940886 PMID:19033392 PMID:23649336 PMID:23830814 More... NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of OPA1 mRNA] CTD PMID:37739047 NCBI chr16:29,398,099...29,481,924
Ensembl chr16:29,398,152...29,473,702 		JBrowse link
G Otx2 orthodenticle homeobox 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA] CTD PMID:31068541 NCBI chr14:48,894,238...48,905,101
Ensembl chr14:48,895,134...48,911,276 		JBrowse link
G Pah phenylalanine hydroxylase decreases expression EXP Thioctic Acid results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998 		JBrowse link
G Pcdhb13 protocadherin beta 13 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of PCDHB6 mRNA] CTD PMID:23608068 NCBI chr18:37,575,570...37,579,262
Ensembl chr18:37,575,553...37,579,262 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of PCNA protein] CTD PMID:21251946 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PINK1 mRNA] CTD PMID:37739047 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618 		JBrowse link
G Plaat3 phospholipase A and acyltransferase 3 decreases activity
decreases expression		 EXP Thioctic Acid results in decreased activity of PLAAT3 protein
Thioctic Acid results in decreased expression of PLAAT3 mRNA		 CTD PMID:22941773 NCBI chr19:7,534,824...7,565,914
Ensembl chr19:7,534,824...7,565,910 		JBrowse link
G Plin1 perilipin 1 increases phosphorylation EXP Thioctic Acid results in increased phosphorylation of PLIN1 protein CTD PMID:22941773 NCBI chr 7:79,370,912...79,382,652
Ensembl chr 7:79,369,966...79,382,651 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity		 EXP
ISO		 [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; [Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]		 CTD PMID:16391466 PMID:21932800 PMID:24120545 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA] CTD PMID:22464149 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO [Thioctic Acid co-treated with Dietary Fats] results in increased expression of PPARG mRNA CTD PMID:22464149 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions
increases expression
decreases expression		 ISO
EXP		 [Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein
Thioctic Acid results in increased expression of PPARGC1A protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]
[Thioctic Acid co-treated with Silicon] results in increased expression of PPARGC1A protein; Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of PPARGC1A mRNA]
Thioctic Acid results in decreased expression of PPARGC1A protein		 CTD PMID:20414966 PMID:22464149 PMID:34252510 PMID:37739047 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta multiple interactions
decreases acetylation		 ISO [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]
Thioctic Acid results in decreased acetylation of PPARGC1B protein		 CTD PMID:22327056 PMID:22464149 NCBI chr18:61,424,516...61,533,846
Ensembl chr18:61,431,207...61,533,502 		JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRDX3 mRNA] CTD PMID:37739047 NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit multiple interactions EXP [Thioctic Acid co-treated with Silicon] results in increased expression of PRKAA2 mRNA CTD PMID:34252510 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRKN mRNA] CTD PMID:37739047 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of PSEN1 protein] CTD PMID:34133789 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]]; Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]] CTD PMID:19735303 PMID:23830814 PMID:26276312 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
decreases phosphorylation		 EXP
ISO		 Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of RELA protein]
Thioctic Acid results in decreased phosphorylation of RELA protein
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of RELA protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA]		 CTD PMID:22488045 PMID:29233029 PMID:34133789 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Reln reelin multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of RELN mRNA CTD PMID:31068541 NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700 		JBrowse link
G S100b S100 protein, beta polypeptide, neural multiple interactions ISO [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein] CTD PMID:23880158 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993 		JBrowse link
G Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SEMA5A mRNA] CTD PMID:23608068 NCBI chr15:32,244,959...32,696,487
Ensembl chr15:32,244,956...32,696,487 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Silicon results in increased expression of SERPINE1 protein] CTD PMID:34252510 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA] CTD PMID:24704557 NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446 		JBrowse link
G Sftpa1 surfactant associated protein A1 multiple interactions ISO Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPA1 mRNA] CTD PMID:25215149 NCBI chr14:40,853,745...40,858,330
Ensembl chr14:40,853,739...40,858,409 		JBrowse link
G Sftpb surfactant associated protein B multiple interactions ISO Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPB mRNA] CTD PMID:25215149 NCBI chr 6:72,281,594...72,291,354
Ensembl chr 6:72,281,594...72,291,354 		JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions		 ISO
EXP		 Thioctic Acid results in increased expression of SIRT1 protein
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA]
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT1 mRNA]
Thioctic Acid results in increased expression of SIRT1 mRNA		 CTD PMID:22327056 PMID:37739047 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression		 ISO
EXP		 [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 mRNA]
Thioctic Acid results in increased expression of SIRT3 protein
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA]		 CTD PMID:22327056 PMID:37739047 NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222 		JBrowse link
G Slc12a2 solute carrier family 12, member 2 multiple interactions
affects activity		 ISO [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia]
Thioctic Acid affects the activity of SLC12A2 protein		 CTD PMID:23880158 NCBI chr18:58,011,505...58,079,893
Ensembl chr18:58,011,750...58,079,893 		JBrowse link
G Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC1A1 mRNA] CTD PMID:32061141 NCBI chr19:28,812,535...28,891,360
Ensembl chr19:28,812,449...28,891,360 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] CTD PMID:23892647 NCBI chr15:96,585,267...96,597,609
Ensembl chr15:96,585,273...96,597,611 		JBrowse link
G Slc5a6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 increases transport
multiple interactions		 ISO SLC5A6 results in increased transport of Thioctic Acid
Sodium affects the reaction [SLC5A6 results in increased transport of Thioctic Acid]
Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]		 CTD PMID:9516450 PMID:10329687 NCBI chr 5:31,193,380...31,206,268
Ensembl chr 5:31,193,380...31,206,268 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC7A11 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC7A11 mRNA] CTD PMID:32061141 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:35187969 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:35187969 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Snca synuclein, alpha multiple interactions ISO [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of SOD1] CTD PMID:15804455 PMID:26518973 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
increases activity		 ISO
EXP		 Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein]
Thioctic Acid results in increased activity of SOD2 protein
[Thioctic Acid co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of SOD2 mRNA]		 CTD PMID:15804455 PMID:19951573 PMID:22327056 PMID:27260466 PMID:34252510 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions EXP Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein CTD PMID:21351249 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:22464149 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA] CTD PMID:28070105 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Thioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein] CTD PMID:19635391 PMID:28086195 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT3 protein] CTD PMID:19635391 PMID:28086195 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions EXP [Thioctic Acid co-treated with Silicon] results in increased expression of STK11 mRNA CTD PMID:34252510 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 increases expression ISO Thioctic Acid results in increased expression of SUMO1 protein CTD PMID:24975507 NCBI chr 1:59,678,593...59,709,993
Ensembl chr 1:59,625,717...59,709,993 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP Thioctic Acid inhibits the reaction [Silicon results in decreased expression of TFAM mRNA] CTD PMID:34252510 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFA mRNA] CTD PMID:29233029 NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP		 Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of TGFB1 protein]		 CTD PMID:15309289 PMID:21251946 PMID:24704557 PMID:26276312 PMID:29760339 More... NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 multiple interactions EXP Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TGFB1I1 mRNA] CTD PMID:23608068 NCBI chr 7:127,845,963...127,852,884
Ensembl chr 7:127,845,984...127,854,871 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA; [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of TGFB2 mRNA CTD PMID:23830814 PMID:31068541 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions EXP Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of THRA mRNA] CTD PMID:27260466 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TNF mRNA; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]]; Thioctic Acid affects the reaction [Paraquat affects the expression of TNF protein]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]		 CTD PMID:15309289 PMID:23830814 PMID:25215149 PMID:26276312 PMID:29233029 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b multiple interactions ISO
EXP		 Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TNFRSF10B mRNA]
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TNFRSF10B mRNA]		 CTD PMID:23608068 PMID:23830814 NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860 		JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of TNFSF10 mRNA CTD PMID:23830814 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576 		JBrowse link
G Tnni3 troponin I, cardiac 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]; Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of TRIB3 mRNA] CTD PMID:23608068 PMID:23892647 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Thioctic Acid inhibits the reaction [Methotrexate results in increased expression of TP53 protein] CTD PMID:19900424 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of TXN1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA] CTD PMID:23830814 PMID:31068541 NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases reduction
multiple interactions		 ISO TXNRD1 protein results in increased reduction of Thioctic Acid
Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]		 CTD PMID:20810785 PMID:21172426 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA] CTD PMID:22327056 PMID:22464149 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO
EXP		 Cyclosporine inhibits the reaction [Thioctic Acid results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased expression of VEGFA mRNA]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of VEGFA mRNA]		 CTD PMID:11596663 PMID:22488045 PMID:26276312 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Wnt5a wingless-type MMTV integration site family, member 5A multiple interactions EXP Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of WNT5A protein] CTD PMID:37739047 NCBI chr14:28,224,962...28,249,405
Ensembl chr14:28,226,707...28,249,405 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO Thioctic Acid inhibits the reaction [Valproic Acid results in increased activity of XDH protein] CTD PMID:32662911 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
lipoamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO lipoamide inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein] CTD PMID:18258206 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases reduction ISO TXNRD1 protein results in increased reduction of lipoamide CTD PMID:21172426 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
G Txnrd2 thioredoxin reductase 2 increases reduction ISO TXNRD2 protein results in increased reduction of lipoamide CTD PMID:21172426 NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22192
    role 22177
      biological role 22176
        antimicrobial agent 19567
          antibacterial agent 16157
            octanoic acid 3364
              lipoic acid 218
                (R)-lipoic acid + 217
                (S)-lipoic acid + 0
                lipoamide + 3
                lipoyl group + 0
                lipoyl-AMP + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22192
    subatomic particle 22184
      composite particle 22184
        hadron 22184
          baryon 22184
            nucleon 22184
              atomic nucleus 22184
                atom 22184
                  main group element atom 22118
                    p-block element atom 22118
                      carbon group element atom 21918
                        carbon atom 21844
                          organic molecular entity 21844
                            heteroorganic entity 21497
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbon oxoacid 19607
                                    carboxylic acid 19603
                                      monocarboxylic acid 18972
                                        fatty acid 17132
                                          saturated fatty acid 16851
                                            straight-chain saturated fatty acid 16274
                                              octanoic acid 3364
                                                lipoic acid 218
                                                  (R)-lipoic acid + 217
                                                  (S)-lipoic acid + 0
                                                  lipoamide + 3
                                                  lipoyl group + 0
                                                  lipoyl-AMP + 0
paths to the root