|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein |
CTD |
PMID:29128272 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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|
G |
Acadl |
acyl-CoA dehydrogenase, long chain |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACADL mRNA] |
CTD |
PMID:22464149 |
|
NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
|
|
G |
Ace |
angiotensin I converting enzyme |
multiple interactions |
EXP ISO |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE] Thioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein]; Thioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA] |
CTD |
PMID:26518973 PMID:27260466 |
|
NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
|
|
G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP ISO |
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein] [Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein] |
CTD |
PMID:19669875 PMID:20663516 PMID:20730314 |
|
NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
|
|
G |
Acox1 |
acyl-CoA oxidase 1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] |
CTD |
PMID:22464149 |
|
NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Mitogens results in increased expression of ACTA2 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] |
CTD |
PMID:21251946 PMID:24704557 PMID:29760339 |
|
NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
|
|
G |
Ada |
adenosine deaminase |
multiple interactions |
EXP |
[Thioctic Acid co-treated with Valproic Acid] results in decreased activity of ADA protein |
CTD |
PMID:32662911 |
|
NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
|
|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions increases expression |
EXP |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] Thioctic Acid results in increased expression of ADIPOQ mRNA; Thioctic Acid results in increased expression of ADIPOQ protein |
CTD |
PMID:22664981 |
|
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Dietary Fats] results in decreased expression of AGT mRNA |
CTD |
PMID:27260466 |
|
NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
|
|
G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
EXP ISO |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1] Thioctic Acid affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA] |
CTD |
PMID:26518973 PMID:27260466 |
|
NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
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|
G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
Thioctic Acid results in decreased phosphorylation of AKT1 protein Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of AKT1 mRNA] |
CTD |
PMID:21351249 PMID:27260466 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
|
|
G |
Alad |
aminolevulinate dehydratase |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] |
CTD |
PMID:19798568 PMID:20026167 PMID:20584200 PMID:21783994 |
|
NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
|
|
G |
Alb |
albumin |
multiple interactions |
EXP ISO |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ALB protein] ALB protein results in increased uptake of [Thioctic Acid binds to Gold] |
CTD |
PMID:24704557 PMID:28433809 |
|
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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|
G |
Apln |
apelin |
multiple interactions increases secretion increases expression |
ISO |
acadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] |
CTD |
PMID:21461750 |
|
NCBI chr X:134,856,719...134,866,210
Ensembl chr X:134,856,726...134,866,210
|
|
G |
Atf4 |
activating transcription factor 4 |
multiple interactions |
ISO EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein] Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein] |
CTD |
PMID:23892647 PMID:30605698 |
|
NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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|
G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF6 mRNA] |
CTD |
PMID:23892647 |
|
NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
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|
G |
Atp1b1 |
ATPase Na+/K+ transporting subunit beta 1 |
multiple interactions |
ISO |
Thioctic Acid affects the reaction [Dietary Fats affects the expression of ATP1B1 mRNA] |
CTD |
PMID:27260466 |
|
NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
|
|
G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
multiple interactions |
ISO |
Thioctic Acid promotes the reaction [Dietary Fats results in decreased expression of ATP2A2 mRNA] |
CTD |
PMID:27260466 |
|
NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased localization of BAX protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein] Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BAX mRNA] [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of BAX mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX protein] |
CTD |
PMID:15735709 PMID:23830814 PMID:23892647 PMID:27544635 PMID:30605698 PMID:32061141 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
|
|
G |
Bbc3 |
Bcl-2 binding component 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BBC3 mRNA] |
CTD |
PMID:23892647 |
|
NCBI chr 1:78,261,491...78,267,802
|
|
G |
Bche |
butyrylcholinesterase |
multiple interactions |
ISO |
[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein] |
CTD |
PMID:20663516 |
|
NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
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|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases response to substance |
ISO EXP |
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]; Thioctic Acid results in increased degradation of and results in decreased expression of BCL2 protein Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA] Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 protein] BCL2 protein results in decreased susceptibility to Thioctic Acid |
CTD |
PMID:16990509 PMID:21600978 PMID:23830814 PMID:27260466 PMID:27544635 PMID:30605698 PMID:32061141 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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|
G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of BCL2L1 mRNA |
CTD |
PMID:23830814 |
|
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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|
G |
Brca2 |
BRCA2, DNA repair associated |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of BRCA2 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
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|
G |
C1qa |
complement C1q A chain |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of C1QA mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
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|
G |
C4b |
complement C4B (Chido blood group) |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of C4B mRNA |
CTD |
PMID:19555370 |
|
NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
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|
G |
Calb2 |
calbindin 2 |
multiple interactions |
EXP |
Thioctic Acid affects the reaction [Propylthiouracil results in increased expression of CALB2 mRNA] |
CTD |
PMID:31068541 |
|
NCBI chr19:41,482,743...41,509,617
Ensembl chr19:41,482,728...41,509,658
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|
G |
Calm1 |
calmodulin 1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of CALM1 mRNA] |
CTD |
PMID:26165643 |
|
NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
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|
G |
Casp3 |
caspase 3 |
multiple interactions increases expression increases activity |
ISO EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein] Thioctic Acid results in increased expression of CASP3 protein modified form Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein] [Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP3 protein modified form]; Thioctic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein] Thioctic Acid results in increased activity of CASP3 protein |
CTD |
PMID:15909127 PMID:17079870 PMID:19951573 PMID:21062633 PMID:21763304 PMID:23892647 PMID:27544635 PMID:29214690 PMID:30605698 PMID:32061141 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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|
G |
Casp8 |
caspase 8 |
multiple interactions |
EXP ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein] |
CTD |
PMID:23830814 PMID:27544635 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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|
G |
Casp9 |
caspase 9 |
increases activity multiple interactions |
ISO EXP |
Thioctic Acid results in increased activity of CASP9 protein Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein] [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CASP9 mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP9 protein modified form]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein] |
CTD |
PMID:16990509 PMID:19951573 PMID:23830814 PMID:27544635 PMID:30605698 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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|
G |
Cat |
catalase |
multiple interactions increases expression increases activity |
ISO EXP |
Thioctic Acid inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased activity of CAT protein] Thioctic Acid results in increased expression of CAT mRNA [Paraquat co-treated with Thioctic Acid] results in increased expression of CAT mRNA Thioctic Acid results in increased activity of CAT protein [acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; Succimer promotes the reaction [Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Valproic Acid results in decreased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]]; Thioctic Acid promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]] |
CTD |
PMID:15998567 PMID:19368863 PMID:19699728 PMID:19715735 PMID:21763304 PMID:22623521 PMID:23649336 PMID:26276312 PMID:27260466 PMID:27581792 PMID:28880400 PMID:29214690 PMID:29760339 PMID:32662911 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of CCL2 mRNA] |
CTD |
PMID:22488045 |
|
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein] |
CTD |
PMID:21600978 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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|
G |
Cd36 |
CD36 molecule |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]] |
CTD |
PMID:21315065 |
|
NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
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|
G |
Cd86 |
CD86 molecule |
increases expression |
ISO |
Thioctic Acid results in increased expression of CD86 protein |
CTD |
PMID:19033392 |
|
NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
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|
G |
Cd8a |
CD8a molecule |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA |
CTD |
PMID:23830814 |
|
NCBI chr 4:99,217,640...99,243,352
Ensembl chr 4:99,239,115...99,243,351
|
|
G |
Cdx4 |
caudal type homeo box 4 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of CDX4 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr X:74,165,172...74,173,758
Ensembl chr X:74,165,187...74,173,347
|
|
G |
Chat |
choline O-acetyltransferase |
multiple interactions |
EXP |
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein |
CTD |
PMID:19669875 |
|
NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
|
|
G |
Cntf |
ciliary neurotrophic factor |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein] |
CTD |
PMID:19635391 |
|
NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of COL1A1 mRNA; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA] |
CTD |
PMID:21251946 PMID:23830814 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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|
G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] |
CTD |
PMID:22464149 |
|
NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
|
|
G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:32061141 |
|
NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
|
|
G |
Crp |
C-reactive protein |
multiple interactions |
EXP |
Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein] |
CTD |
PMID:26276312 |
|
NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
|
|
G |
Cryaa |
crystallin, alpha A |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [naphthalene results in increased cleavage of CRYAA protein] |
CTD |
PMID:20597648 |
|
NCBI chr20:10,438,444...10,442,189
Ensembl chr20:10,438,444...10,442,187
|
|
G |
Ctsd |
cathepsin D |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] |
CTD |
PMID:12841641 |
|
NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
|
|
G |
Ctss |
cathepsin S |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of CTSS mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
|
|
G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB] |
CTD |
PMID:26518973 |
|
NCBI chr X:14,578,330...14,610,049
Ensembl chr X:14,578,264...14,612,547
|
|
G |
Cycs |
cytochrome c, somatic |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] |
CTD |
PMID:19951573 |
|
NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] |
CTD |
PMID:21932800 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:21932800 PMID:24120545 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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|
G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
|
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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|
G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
|
NCBI chr 1:147,236,480...147,307,988
|
|
G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
|
NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO |
Thioctic Acid affects the reaction [cyanoginosin LR affects the expression of CYP2E1 protein] |
CTD |
PMID:32061150 |
|
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
|
|
G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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|
G |
Dab1 |
DAB adaptor protein 1 |
multiple interactions |
EXP |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of DAB1 mRNA |
CTD |
PMID:31068541 |
|
NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein] Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein] |
CTD |
PMID:23892647 PMID:30605698 |
|
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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|
G |
Dgat2 |
diacylglycerol O-acyltransferase 2 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA] |
CTD |
PMID:22464149 |
|
NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
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G |
Dio1 |
iodothyronine deiodinase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of DIO1 mRNA] |
CTD |
PMID:27260466 |
|
NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
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|
G |
Dld |
dihydrolipoamide dehydrogenase |
multiple interactions |
EXP |
[5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] |
CTD |
PMID:21551353 |
|
NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein] |
CTD |
PMID:20730801 |
|
NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
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|
G |
Eif2a |
eukaryotic translation initiation factor 2A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2A protein] |
CTD |
PMID:23892647 |
|
NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form] |
CTD |
PMID:30605698 |
|
NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
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G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein] |
CTD |
PMID:27544635 |
|
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of FOS mRNA |
CTD |
PMID:31068541 |
|
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Foxo3 |
forkhead box O3 |
decreases acetylation multiple interactions |
EXP |
Thioctic Acid results in decreased acetylation of FOXO3 protein [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein |
CTD |
PMID:22327056 |
|
NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
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G |
Fras1 |
Fraser extracellular matrix complex subunit 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FRAS1 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr14:14,438,392...14,853,016
Ensembl chr14:14,439,082...14,689,554
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of FSHB protein] |
CTD |
PMID:20957662 |
|
NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
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G |
Gad1 |
glutamate decarboxylase 1 |
multiple interactions |
EXP |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GAD1 mRNA |
CTD |
PMID:31068541 |
|
NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression multiple interactions |
ISO EXP |
Thioctic Acid results in increased expression of GCLC mRNA Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein] |
CTD |
PMID:16249512 PMID:17940886 PMID:27298056 PMID:32061141 |
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NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression multiple interactions |
ISO EXP |
Thioctic Acid results in increased expression of GCLM mRNA Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM protein] |
CTD |
PMID:16249512 PMID:32061141 |
|
NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
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G |
Gfap |
glial fibrillary acidic protein |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of GFAP mRNA |
CTD |
PMID:19555370 |
|
NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] |
CTD |
PMID:24704557 |
|
NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
EXP ISO |
Thioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein]; Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA] Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA] |
CTD |
PMID:26165643 PMID:27260466 |
|
NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
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G |
Gls |
glutaminase |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GLS protein] |
CTD |
PMID:32061141 |
|
NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
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G |
Gnrhr |
gonadotropin releasing hormone receptor |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GNRHR mRNA] |
CTD |
PMID:28070105 |
|
NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GPT protein] |
CTD |
PMID:24704557 |
|
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
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G |
Gpx1 |
glutathione peroxidase 1 |
increases expression multiple interactions |
ISO EXP |
Thioctic Acid results in increased expression of GPX1 mRNA Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GPX1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GPX1 mRNA] |
CTD |
PMID:23649336 PMID:32061141 |
|
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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G |
Gpx2 |
glutathione peroxidase 2 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA |
CTD |
PMID:23830814 |
|
NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
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G |
Gpx3 |
glutathione peroxidase 3 |
increases expression multiple interactions |
ISO |
Thioctic Acid results in increased expression of GPX3 mRNA [Paraquat co-treated with Thioctic Acid] results in increased expression of GPX3 mRNA |
CTD |
PMID:23649336 |
|
NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
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G |
Gpx5 |
glutathione peroxidase 5 |
increases expression |
ISO |
Thioctic Acid results in increased expression of GPX5 mRNA |
CTD |
PMID:23649336 |
|
NCBI chr17:45,508,657...45,518,686
Ensembl chr17:45,467,015...45,518,686
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 protein] |
CTD |
PMID:32061141 |
|
NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
multiple interactions |
EXP |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GRIN2A mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A protein] |
CTD |
PMID:31068541 PMID:32061141 |
|
NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation multiple interactions |
ISO |
Thioctic Acid results in increased phosphorylation of GSK3B protein Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA] |
CTD |
PMID:19879292 PMID:27260466 |
|
NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions increases expression |
EXP ISO |
Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of GSR protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein] Thioctic Acid inhibits the reaction [cyanoginosin LR results in decreased activity of GSR protein] Thioctic Acid results in increased expression of GSR mRNA |
CTD |
PMID:19699728 PMID:22623521 PMID:23649336 PMID:27581792 PMID:32061150 |
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NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Gss |
glutathione synthetase |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of GSS protein] |
CTD |
PMID:32061141 |
|
NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
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G |
Gstm1 |
glutathione S-transferase mu 1 |
multiple interactions |
EXP ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA [Dietary Fats co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA |
CTD |
PMID:18367378 PMID:23830814 |
|
NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
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G |
Gstm7 |
glutathione S-transferase, mu 7 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of GSTM7 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr 2:210,720,719...210,726,179
Ensembl chr 2:210,720,704...210,782,856
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions increases expression |
EXP |
[Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; Thioctic Acid results in increased expression of and results in increased activity of GSTP1 protein Thioctic Acid results in increased expression of GSTP1 mRNA |
CTD |
PMID:20237067 |
|
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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G |
Gusb |
glucuronidase, beta |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] |
CTD |
PMID:19699728 |
|
NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
ISO |
[Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein |
CTD |
PMID:28433809 |
|
NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO EXP |
[Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of HMOX1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein] Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 protein] Thioctic Acid results in increased expression of HMOX1 mRNA; Thioctic Acid results in increased expression of HMOX1 protein Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of HMOX1 mRNA] |
CTD |
PMID:19033392 PMID:21315065 PMID:22488045 PMID:23649336 PMID:23942037 PMID:24361488 PMID:27260466 PMID:27298056 PMID:30758914 PMID:31319135 PMID:32061141 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Hs1bp3 |
HCLS1 binding protein 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of HS1BP3 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr 6:33,517,711...33,548,015
Ensembl chr 6:33,517,769...33,548,034
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|
G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA] |
CTD |
PMID:28880400 |
|
NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
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|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HSPA5 protein] Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein] |
CTD |
PMID:23892647 PMID:30605698 |
|
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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|
G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA] |
CTD |
PMID:28880400 |
|
NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
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|
G |
Il10 |
interleukin 10 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of IL10]; Thioctic Acid promotes the reaction [Carrageenan results in increased expression of IL10 mRNA] |
CTD |
PMID:19735303 PMID:26518973 |
|
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
|
|
G |
Il1a |
interleukin 1 alpha |
multiple interactions |
EXP |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of IL1A mRNA |
CTD |
PMID:31068541 |
|
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL1B mRNA; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL1B] Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] |
CTD |
PMID:23830814 PMID:24975507 PMID:26518973 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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|
G |
Il2 |
interleukin 2 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL2 protein] |
CTD |
PMID:21195065 |
|
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
|
|
G |
Il22ra2 |
interleukin 22 receptor subunit alpha 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of IL22RA2 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr 1:15,084,136...15,107,423
Ensembl chr 1:15,093,599...15,106,954
|
|
G |
Il4 |
interleukin 4 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL4 mRNA |
CTD |
PMID:23830814 |
|
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of IL6 mRNA] [Thioctic Acid binds to Gold] which results in increased expression of IL6 protein acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL6]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]] |
CTD |
PMID:22488045 PMID:26518973 PMID:28433809 PMID:29760339 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] |
CTD |
PMID:16505238 |
|
NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
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G |
Irf1 |
interferon regulatory factor 1 |
multiple interactions |
ISO |
Thioctic Acid results in increased sumoylation of and results in decreased activity of IRF1 protein |
CTD |
PMID:24975507 |
|
NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression increases activity |
EXP |
[Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer] Thioctic Acid results in increased expression of JUN protein Thioctic Acid results in increased activity of JUN protein |
CTD |
PMID:20237067 |
|
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
increases expression |
ISO |
Thioctic Acid results in increased expression of KEAP1 protein |
CTD |
PMID:19033392 |
|
NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
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|
G |
Ldhc |
lactate dehydrogenase C |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased expression of LDHC protein] |
CTD |
PMID:21195065 PMID:27581792 |
|
NCBI chr 1:102,914,875...102,931,843
Ensembl chr 1:102,915,191...102,931,839
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G |
Lep |
leptin |
decreases secretion decreases expression |
ISO EXP |
Thioctic Acid results in decreased secretion of LEP protein Thioctic Acid results in decreased expression of LEP mRNA; Thioctic Acid results in decreased expression of LEP protein |
CTD |
PMID:21351249 |
|
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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|
G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of LHB protein]; Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LHB mRNA] |
CTD |
PMID:20957662 PMID:28070105 |
|
NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
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G |
Lipe |
lipase E, hormone sensitive type |
multiple interactions increases phosphorylation |
ISO |
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein] |
CTD |
PMID:22941773 |
|
NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
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G |
Mapk1 |
mitogen activated protein kinase 1 |
affects activity multiple interactions |
EXP |
Thioctic Acid affects the activity of MAPK1 protein Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK1 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK1 protein] |
CTD |
PMID:15909127 PMID:21251946 PMID:32061141 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK14 mRNA |
CTD |
PMID:23830814 |
|
NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK3 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK3 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK3 protein] |
CTD |
PMID:21251946 PMID:23830814 PMID:32061141 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK8 mRNA |
CTD |
PMID:23830814 |
|
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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G |
Mir21 |
microRNA 21 |
multiple interactions |
EXP |
Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA] |
CTD |
PMID:26276312 |
|
NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
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|
G |
Mir210 |
microRNA 210 |
multiple interactions |
EXP |
[Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]] |
CTD |
PMID:26276312 |
|
NCBI chr 1:214,208,355...214,208,464
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|
G |
Mmp12 |
matrix metallopeptidase 12 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA |
CTD |
PMID:23830814 |
|
NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
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G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] |
CTD |
PMID:24975507 |
|
NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of MMP2 mRNA |
CTD |
PMID:23830814 |
|
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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G |
Mmp3 |
matrix metallopeptidase 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] |
CTD |
PMID:24975507 |
|
NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
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G |
Msr1 |
macrophage scavenger receptor 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]] |
CTD |
PMID:21315065 |
|
NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
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G |
Mt1 |
metallothionein 1 |
multiple interactions |
ISO |
[Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MT1 mRNA |
CTD |
PMID:18367378 |
|
NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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G |
Mvd |
mevalonate diphosphate decarboxylase |
multiple interactions |
ISO |
[Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MVD mRNA |
CTD |
PMID:18367378 |
|
NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein] |
CTD |
PMID:21600978 |
|
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of NCF1] |
CTD |
PMID:26518973 |
|
NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
multiple interactions affects localization increases expression increases activity decreases expression |
ISO EXP |
[Paraquat co-treated with Thioctic Acid] results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NFE2L2 mRNA]; Thioctic Acid promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thioctic Acid results in increased expression of and affects the localization of NFE2L2 protein Thioctic Acid affects the localization of NFE2L2 protein Thioctic Acid results in increased expression of NFE2L2 mRNA; Thioctic Acid results in increased expression of NFE2L2 protein Thioctic Acid results in increased activity of NFE2L2 protein [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer] Thioctic Acid results in decreased expression of NFE2L2 mRNA; Thioctic Acid results in decreased expression of NFE2L2 protein [Thioctic Acid co-treated with cyanoginosin LR] results in increased expression of NFE2L2 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of NFE2L2 mRNA] |
CTD |
PMID:17197552 PMID:18258206 PMID:20237067 PMID:22488045 PMID:23649336 PMID:24361488 PMID:27260466 PMID:27298056 PMID:30758914 PMID:31319135 PMID:32061141 PMID:32061150 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO EXP |
Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein] [Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA |
CTD |
PMID:21600978 PMID:31068541 |
|
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Ngfr |
nerve growth factor receptor |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TNFRSF10B mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of NOS2]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:15453632 PMID:21763304 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] |
CTD |
PMID:27260466 |
|
NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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G |
Nox1 |
NADPH oxidase 1 |
multiple interactions |
EXP |
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]] |
CTD |
PMID:29760339 |
|
NCBI chr X:104,909,328...104,932,508
Ensembl chr X:104,909,326...104,932,508
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G |
Nox4 |
NADPH oxidase 4 |
multiple interactions |
EXP |
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]] |
CTD |
PMID:29760339 |
|
NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity increases expression multiple interactions |
ISO EXP |
Thioctic Acid results in increased activity of NQO1 protein Thioctic Acid results in increased expression of NQO1 mRNA; Thioctic Acid results in increased expression of NQO1 protein [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein] [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA] |
CTD |
PMID:12180195 PMID:17940886 PMID:19033392 PMID:23649336 PMID:23830814 PMID:30758914 PMID:31068541 PMID:31319135 |
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NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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G |
Otx2 |
orthodenticle homeobox 2 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA] |
CTD |
PMID:31068541 |
|
NCBI chr15:25,500,037...25,511,619
Ensembl chr15:25,502,019...25,505,691
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G |
Pah |
phenylalanine hydroxylase |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of PAH mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
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G |
Pcdhb6l |
protocadherin beta-6-like |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of PCDHB6 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr18:30,512,507...30,518,524
Ensembl chr18:30,515,962...30,518,352
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of PCNA protein] |
CTD |
PMID:21251946 |
|
NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
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G |
Plaat3 |
phospholipase A and acyltransferase 3 |
decreases expression decreases activity |
ISO |
Thioctic Acid results in decreased expression of PLAAT3 mRNA Thioctic Acid results in decreased activity of PLAAT3 protein |
CTD |
PMID:22941773 |
|
NCBI chr 1:222,844,238...222,877,180
Ensembl chr 1:222,844,144...222,877,193
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G |
Plin1 |
perilipin 1 |
increases phosphorylation |
ISO |
Thioctic Acid results in increased phosphorylation of PLIN1 protein |
CTD |
PMID:22941773 |
|
NCBI chr 1:141,458,907...141,470,927
Ensembl chr 1:141,458,181...141,471,010
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G |
Por |
cytochrome p450 oxidoreductase |
multiple interactions decreases activity |
ISO |
[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; [Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:16391466 PMID:21932800 PMID:24120545 |
|
NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA] |
CTD |
PMID:22464149 |
|
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP |
[Thioctic Acid co-treated with Dietary Fats] results in increased expression of PPARG mRNA |
CTD |
PMID:22464149 |
|
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions increases expression |
ISO EXP |
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA] Thioctic Acid results in increased expression of PPARGC1A protein |
CTD |
PMID:20414966 PMID:22464149 |
|
NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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G |
Ppargc1b |
PPARG coactivator 1 beta |
multiple interactions decreases acetylation |
EXP |
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA] Thioctic Acid results in decreased acetylation of PPARGC1B protein |
CTD |
PMID:22327056 PMID:22464149 |
|
NCBI chr18:56,626,725...56,650,524
Ensembl chr18:56,626,712...56,728,968
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
[Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]]; Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]] |
CTD |
PMID:19735303 PMID:23830814 PMID:26276312 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases phosphorylation |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of RELA protein] Thioctic Acid results in decreased phosphorylation of RELA protein |
CTD |
PMID:22488045 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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|
G |
Reln |
reelin |
multiple interactions |
EXP |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of RELN mRNA |
CTD |
PMID:31068541 |
|
NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
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|
G |
S100b |
S100 calcium binding protein B |
multiple interactions |
EXP |
[Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein] |
CTD |
PMID:23880158 |
|
NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
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|
G |
Sema5a |
semaphorin 5A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SEMA5A mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr 2:85,377,318...85,808,970
Ensembl chr 2:85,377,318...85,808,970
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|
G |
Serpinh1 |
serpin family H member 1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA] |
CTD |
PMID:24704557 |
|
NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
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|
G |
Sftpa1 |
surfactant protein A1 |
multiple interactions |
EXP |
Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPA1 mRNA] |
CTD |
PMID:25215149 |
|
NCBI chr16:18,716,019...18,719,404
Ensembl chr16:18,716,019...18,719,403
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|
G |
Sftpb |
surfactant protein B |
multiple interactions |
EXP |
Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPB mRNA] |
CTD |
PMID:25215149 |
|
NCBI chr 4:100,166,855...100,175,941
Ensembl chr 4:100,166,863...100,175,938
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G |
Sirt1 |
sirtuin 1 |
increases expression multiple interactions |
EXP |
Thioctic Acid results in increased expression of SIRT1 protein [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA] |
CTD |
PMID:22327056 |
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NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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G |
Sirt3 |
sirtuin 3 |
multiple interactions increases expression |
EXP |
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 mRNA] Thioctic Acid results in increased expression of SIRT3 protein |
CTD |
PMID:22327056 |
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NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
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G |
Slc12a2 |
solute carrier family 12 member 2 |
multiple interactions affects activity |
EXP |
[Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia] Thioctic Acid affects the activity of SLC12A2 protein |
CTD |
PMID:23880158 |
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NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
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G |
Slc1a1 |
solute carrier family 1 member 1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC1A1 mRNA] |
CTD |
PMID:32061141 |
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NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
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G |
Slc38a2 |
solute carrier family 38, member 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] |
CTD |
PMID:23892647 |
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NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
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G |
Slc5a6 |
solute carrier family 5 member 6 |
increases transport multiple interactions |
ISO EXP |
SLC5A6 results in increased transport of Thioctic Acid Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid] Sodium affects the reaction [SLC5A6 results in increased transport of Thioctic Acid] |
CTD |
PMID:9516450 PMID:10329687 |
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NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116
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G |
Slc7a11 |
solute carrier family 7 member 11 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC7A11 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC7A11 mRNA] |
CTD |
PMID:32061141 |
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NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
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G |
Snca |
synuclein alpha |
multiple interactions |
ISO |
[Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein] |
CTD |
PMID:20414966 |
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NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of SOD1] |
CTD |
PMID:15804455 PMID:26518973 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions increases activity |
EXP ISO |
Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein] [Thioctic Acid co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA Thioctic Acid results in increased activity of SOD2 protein |
CTD |
PMID:15804455 PMID:19951573 PMID:22327056 PMID:27260466 |
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NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Sp1 |
Sp1 transcription factor |
multiple interactions |
ISO |
Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein |
CTD |
PMID:21351249 |
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NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] |
CTD |
PMID:22464149 |
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NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA] |
CTD |
PMID:28070105 |
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NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
Thioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein] |
CTD |
PMID:19635391 PMID:28086195 |
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NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT3 protein] |
CTD |
PMID:19635391 PMID:28086195 |
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NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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G |
Sumo1 |
small ubiquitin-like modifier 1 |
increases expression |
ISO |
Thioctic Acid results in increased expression of SUMO1 protein |
CTD |
PMID:24975507 |
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NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA] |
CTD |
PMID:15309289 PMID:21251946 PMID:24704557 PMID:26276312 PMID:29760339 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tgfb1i1 |
transforming growth factor beta 1 induced transcript 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TGFB1I1 mRNA] |
CTD |
PMID:23608068 |
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NCBI chr 1:199,664,039...199,670,970
Ensembl chr 1:199,664,173...199,670,961
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G |
Tgfb2 |
transforming growth factor, beta 2 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA; [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of TGFB2 mRNA |
CTD |
PMID:23830814 PMID:31068541 |
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NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
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G |
Thra |
thyroid hormone receptor alpha |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of THRA mRNA] |
CTD |
PMID:27260466 |
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NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TNF mRNA; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]]; Thioctic Acid affects the reaction [Paraquat affects the expression of TNF protein]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]] |
CTD |
PMID:15309289 PMID:23830814 PMID:25215149 PMID:26276312 PMID:29760339 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tnfrsf26 |
tumor necrosis factor receptor superfamily, member 26 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TNFRSF10B mRNA] |
CTD |
PMID:23830814 |
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NCBI chr 1:216,808,642...216,829,361
Ensembl chr 1:216,808,632...216,828,651
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of TNFSF10 mRNA |
CTD |
PMID:23830814 |
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NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
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G |
Tnni3 |
troponin I3, cardiac type |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] |
CTD |
PMID:21034734 |
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NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Methotrexate results in increased expression of TP53 protein] |
CTD |
PMID:19900424 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Trib3 |
tribbles pseudokinase 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]; Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of TRIB3 mRNA] |
CTD |
PMID:23608068 PMID:23892647 |
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NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
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G |
Txn1 |
thioredoxin 1 |
multiple interactions |
EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of TXN1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA] |
CTD |
PMID:23830814 PMID:31068541 |
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NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
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G |
Txnrd1 |
thioredoxin reductase 1 |
increases reduction multiple interactions |
ISO EXP |
TXNRD1 protein results in increased reduction of Thioctic Acid Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein] |
CTD |
PMID:20810785 PMID:21172426 |
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NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
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G |
Ucp2 |
uncoupling protein 2 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA] |
CTD |
PMID:22327056 PMID:22464149 |
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NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions increases expression |
EXP ISO |
Cyclosporine inhibits the reaction [Thioctic Acid results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased expression of VEGFA mRNA] Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of VEGFA mRNA] |
CTD |
PMID:11596663 PMID:22488045 PMID:26276312 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Valproic Acid results in increased activity of XDH protein] |
CTD |
PMID:32662911 |
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NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
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