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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332548
Species: Mus musculus
RGD Object: Gene
Symbol: Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Acc ID: CHEBI:16494
Term: lipoic acid
Definition: A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
Chemical ID: MESH:D008063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1adecreases expressionEXP 6480464CTDThioctic Acid results in decreased expression of PPARGC1A proteinPMID:37739047
Ppargc1amultiple interactionsEXP 6480464CTD[Thioctic Acid co-treated with Silicon] results in increased expression of PPARGC1A protein; Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of PPARGC1A mRNA]PMID:34252510 PMID:37739047
Ppargc1aincreases expressionISOPPARGC1A (Homo sapiens)6480464CTDThioctic Acid results in increased expression of PPARGC1A proteinPMID:20414966
Ppargc1amultiple interactionsISOPPARGC1A (Homo sapiens)6480464CTD[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A proteinPMID:20414966
Ppargc1amultiple interactionsISOPpargc1a (Rattus norvegicus)6480464CTDThioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]PMID:22464149
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