(+)-schisandrin B multiple interactions ISO RGD:2316 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CD8A mRNA] CTD PMID:31150632 (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin multiple interactions EXP 6480464 Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Carbon Tetrachloride results in increased expression of CD8A mRNA] CTD PMID:17299060 (R)-lipoic acid multiple interactions ISO RGD:2316 6480464 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA CTD PMID:23830814 1-naphthyl isothiocyanate decreases expression ISO RGD:2316 6480464 1-Naphthylisothiocyanate results in decreased expression of CD8A mRNA CTD PMID:30723492 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of CD8A mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of CD8A mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression ISO RGD:2316 6480464 Ethinyl Estradiol results in decreased expression of CD8A mRNA CTD PMID:15576828 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD8A mRNA CTD PMID:17942748 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of CD8A mRNA CTD PMID:19484750 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:735285 6480464 Tetrachlorodibenzodioxin results in decreased expression of CD8A mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CD8A protein CTD PMID:14718643 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD8A mRNA, Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CD8A protein] CTD PMID:17942748 , PMID:20715097 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:735285 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of CD8A mRNA CTD PMID:19684285 5-fluorouracil multiple interactions ISO RGD:735285 6480464 TP53 protein affects the reaction [Fluorouracil results in decreased expression of CD8A mRNA] CTD PMID:15016801 6-propyl-2-thiouracil increases expression ISO RGD:2316 6480464 Propylthiouracil results in increased expression of CD8A mRNA CTD PMID:22504374 acetylsalicylic acid decreases expression ISO RGD:735285 6480464 Aspirin results in decreased expression of CD8A mRNA CTD PMID:15928584 acrolein multiple interactions EXP 6480464 CD8A gene mutant form inhibits the reaction [Acrolein results in increased activity of MMP2 protein] more ... CTD PMID:17950725 aflatoxin B1 increases methylation ISO RGD:735285 6480464 Aflatoxin B1 results in increased methylation of CD8A intron CTD PMID:30157460 ammonium chloride affects expression ISO RGD:2316 6480464 Ammonium Chloride affects the expression of CD8A mRNA CTD PMID:16483693 antirheumatic drug decreases expression ISO RGD:735285 6480464 Antirheumatic Agents results in decreased expression of CD8A mRNA CTD PMID:24449571 arsane affects methylation ISO RGD:735285 6480464 Arsenic affects the methylation of CD8A gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:735285 6480464 Arsenic affects the methylation of CD8A gene CTD PMID:25304211 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of CD8A mRNA CTD PMID:21569818 bisphenol A decreases expression ISO RGD:2316 6480464 bisphenol A results in decreased expression of CD8A mRNA CTD PMID:25181051 buta-1,3-diene decreases expression EXP 6480464 1, 3-butadiene results in decreased expression of CD8A mRNA CTD PMID:29038090 butanal increases expression ISO RGD:735285 6480464 butyraldehyde results in increased expression of CD8A mRNA CTD PMID:26079696 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon results in increased expression of CD8A mRNA CTD PMID:25554681 chloroprene decreases expression EXP 6480464 Chloroprene results in decreased expression of CD8A mRNA CTD PMID:23125180 cisplatin decreases expression ISO RGD:735285 6480464 Cisplatin results in decreased expression of CD8A mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:735285 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of CD8A mRNA CTD PMID:27392435 cycloheximide multiple interactions ISO RGD:735285 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of CD8A mRNA CTD PMID:19684285 cyclophosphamide decreases expression EXP 6480464 Cyclophosphamide results in decreased expression of CD8A mRNA CTD PMID:21041162 cytarabine increases expression ISO RGD:735285 6480464 Cytarabine results in increased expression of CD8A mRNA CTD PMID:19194470 decabromodiphenyl ether increases expression ISO RGD:2316 6480464 decabromobiphenyl ether results in increased expression of CD8A mRNA CTD PMID:23914054 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of CD8A mRNA CTD PMID:21041162 dichloroacetic acid increases expression EXP 6480464 Dichloroacetic Acid results in increased expression of CD8A mRNA CTD PMID:28962523 dichloromethane increases expression ISO RGD:2316 6480464 Methylene Chloride results in increased expression of CD8A mRNA CTD PMID:20955722 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of CD8A mRNA CTD PMID:21041162 ethylbenzene increases expression ISO RGD:2316 6480464 ethylbenzene results in increased expression of CD8A mRNA CTD PMID:20955722 flavonoids increases expression ISO RGD:2316 6480464 Flavonoids results in increased expression of CD8A mRNA CTD PMID:18035473 fluoxetine increases expression EXP 6480464 Fluoxetine results in increased expression of CD8A protein CTD PMID:21497159 fonofos increases methylation ISO RGD:735285 6480464 Fonofos results in increased methylation of CD8A promoter CTD PMID:22847954 gentamycin increases expression ISO RGD:2316 6480464 Gentamicins results in increased expression of CD8A mRNA CTD PMID:22061828 glycidol decreases expression ISO RGD:2316 6480464 glycidol results in decreased expression of CD8A mRNA CTD PMID:24915197 lipoic acid multiple interactions ISO RGD:2316 6480464 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA CTD PMID:23830814 methimazole increases expression ISO RGD:2316 6480464 Methimazole results in increased expression of CD8A mRNA CTD PMID:22504374 methotrexate decreases expression ISO RGD:735285 6480464 Methotrexate results in decreased expression of CD8A protein CTD PMID:15476228 N-nitrosodiethylamine multiple interactions ISO RGD:2316 6480464 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA, [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD8A mRNA CTD PMID:23830814 nickel atom increases expression ISO RGD:735285 6480464 Nickel results in increased expression of CD8A mRNA CTD PMID:25583101 nickel sulfate increases expression ISO RGD:735285 6480464 nickel sulfate results in increased expression of CD8A mRNA CTD PMID:16780908 oxaliplatin increases expression ISO RGD:2316 6480464 oxaliplatin results in increased expression of CD8A mRNA CTD PMID:25729387 oxaliplatin multiple interactions ISO RGD:2316 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of CD8A mRNA CTD PMID:25729387 parathion increases methylation ISO RGD:735285 6480464 Parathion results in increased methylation of CD8A promoter CTD PMID:22847954 pentanal increases expression ISO RGD:735285 6480464 pentanal results in increased expression of CD8A mRNA CTD PMID:26079696 phenacetin decreases expression ISO RGD:2316 6480464 Phenacetin results in decreased expression of CD8A mRNA CTD PMID:17698508 phenylhydrazine decreases expression ISO RGD:2316 6480464 phenylhydrazine results in decreased expression of CD8A mRNA CTD PMID:17698508 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of CD8A mRNA CTD PMID:17426115 propanal increases expression ISO RGD:735285 6480464 propionaldehyde results in increased expression of CD8A mRNA CTD PMID:26079696 raloxifene affects expression ISO RGD:2316 6480464 Raloxifene Hydrochloride affects the expression of CD8A mRNA CTD PMID:16079270 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CD8A protein] CTD PMID:20715097 sodium arsenite decreases expression ISO RGD:735285 6480464 sodium arsenite results in decreased expression of CD8A protein CTD PMID:16275621 sodium arsenite affects methylation ISO RGD:735285 6480464 sodium arsenite affects the methylation of CD8A gene CTD PMID:28589171 Soman increases expression ISO RGD:2316 6480464 Soman results in increased expression of CD8A mRNA CTD PMID:19281266 terbufos increases methylation ISO RGD:735285 6480464 terbufos results in increased methylation of CD8A promoter CTD PMID:22847954 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of CD8A mRNA CTD PMID:17299060 tetrachloromethane decreases expression ISO RGD:2316 6480464 Carbon Tetrachloride results in decreased expression of CD8A mRNA CTD PMID:31150632 tetrachloromethane multiple interactions ISO RGD:2316 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CD8A mRNA] CTD PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Carbon Tetrachloride results in increased expression of CD8A mRNA] CTD PMID:17299060 thioacetamide multiple interactions ISO RGD:2316 6480464 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA, [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD8A mRNA CTD PMID:23830814 topotecan multiple interactions ISO RGD:2316 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of CD8A mRNA CTD PMID:25729387 topotecan increases expression ISO RGD:2316 6480464 Topotecan results in increased expression of CD8A mRNA CTD PMID:25729387 trichloroethene increases expression ISO RGD:2316 6480464 Trichloroethylene results in increased expression of CD8A mRNA CTD PMID:20955722 vinclozolin increases expression ISO RGD:2316 6480464 vinclozolin results in increased expression of CD8A mRNA CTD PMID:23034163
Biological Process adaptive immune response IEA UniProtKB-KW:KW-1064 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cell surface receptor signaling pathway IDA 2290270 (MGI:MGI:893249, PMID:9208839) MGI MGI:MGI:893249 , PMID:9208839 cell surface receptor signaling pathway IBA MGI:MGI:88346 , PANTHER:PTN000047644 2290270 (PMID:21873635) GO_Central PMID:21873635 cytotoxic T cell differentiation IMP MGI:MGI:1857149 2290270 (MGI:MGI:1933767, PMID:1673361) MGI MGI:MGI:1933767 , PMID:1673361 cytotoxic T cell differentiation IBA MGI:MGI:88346 , PANTHER:PTN000047644 2290270 (PMID:21873635) GO_Central PMID:21873635 defense response to virus IDA 2290270 (MGI:MGI:3829555, PMID:17277142) MGI MGI:MGI:3829555 , PMID:17277142 immune system process IEA UniProtKB-KW:KW-0391 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 positive regulation of calcium-mediated signaling IDA 2290270 (MGI:MGI:893249, PMID:9208839) MGI MGI:MGI:893249 , PMID:9208839 T cell activation ISO RGD:2316 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 T cell mediated immunity IMP MGI:MGI:1857149 2290270 (MGI:MGI:1933767, PMID:1673361) MGI MGI:MGI:1933767 , PMID:1673361 T cell mediated immunity IBA MGI:MGI:88346 , PANTHER:PTN000047644 2290270 (PMID:21873635) GO_Central PMID:21873635 Cellular Component cell surface IDA 2290270 (MGI:MGI:2678982, PMID:14568922) MGI MGI:MGI:2678982 , PMID:14568922 external side of plasma membrane ISO UniProtKB:P01732 2290270 (MGI:MGI:3834312, PMID:17213291) MGI MGI:MGI:3834312 , PMID:17213291 external side of plasma membrane IBA MGI:MGI:88346 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 external side of plasma membrane IDA 2290270 (MGI:MGI:1332382 more ... MGI MGI:MGI:1332382 more ... integral component of membrane IEA UniProtKB-KW:KW-0812 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 plasma membrane ISO UniProtKB:P01732 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 plasma membrane raft ISO UniProtKB:P01732 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 Molecular Function identical protein binding IPI UniProtKB:P01731 2290270 (MGI:MGI:3576144, PMID:15749886) MGI MGI:MGI:3576144 , PMID:15749886 MHC class I protein complex binding ISO UniProtKB:P01732 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein binding IPI UniProtKB:P06240 2290270 (MGI:MGI:3690806 more ... IntAct MGI:MGI:3690806 more ... protein kinase binding ISO RGD:2316 2290270 RGD GO_REF:0000096, MGI:MGI:4417868
Gene-Chemical Interaction Annotations
