Cd8a (CD8 antigen, alpha chain) - Rat Genome Database
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Gene: Cd8a (CD8 antigen, alpha chain) Mus musculus
Analyze
Symbol: Cd8a
Name: CD8 antigen, alpha chain
RGD ID: 10317
MGI Page MGI
Description: Exhibits identical protein binding activity. Involved in several processes, including cytotoxic T cell differentiation; defense response to virus; and positive regulation of calcium-mediated signaling. Localizes to external side of plasma membrane. Is expressed in several structures, including endocrine gland; exocrine gland; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human CD8A (CD8a molecule); PARTICIPATES IN interleukin-12 signaling pathway; antigen processing and presentation pathway; primary immunodeficiency pathway; INTERACTS WITH (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BB154331; Ly-; Ly-2; Ly-3; Ly-35; Ly-B; Lyt-; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39671,350,411 - 71,356,155 (+)NCBIGRCm39mm39
GRCm38671,373,427 - 71,379,171 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl671,373,427 - 71,379,173 (+)EnsemblGRCm38mm10GRCm38
MGSCv37671,323,421 - 71,329,165 (+)NCBIGRCm37mm9NCBIm37
MGSCv36671,302,936 - 71,308,680 (+)NCBImm8
Celera673,452,794 - 73,458,537 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (EXP)
(R)-lipoic acid  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
carbon nanotube  (EXP)
chloroprene  (EXP)
cisplatin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
dichloroacetic acid  (EXP)
dichloromethane  (ISO)
diethylstilbestrol  (EXP)
endosulfan  (ISO)
ethylbenzene  (ISO)
flavonoids  (ISO)
fluoxetine  (EXP)
fonofos  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
lipoic acid  (ISO)
methcathinone  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (ISO)
parathion  (ISO)
PCB138  (EXP)
pentanal  (ISO)
phenacetin  (ISO)
phenylhydrazine  (ISO)
pirinixic acid  (EXP)
propanal  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
Soman  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive T cell differentiation  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha-beta T cell differentiation  (IAGP)
abnormal CD8-positive, alpha-beta T cell physiology  (IEA)
abnormal cytotoxic T cell physiology  (IAGP)
abnormal dendritic cell morphology  (IAGP)
abnormal double-negative T cell morphology  (IAGP)
abnormal double-positive T cell morphology  (IAGP)
abnormal gamma-delta intraepithelial T cell morphology  (IAGP)
abnormal gamma-delta T cell number  (IAGP)
abnormal positive T cell selection  (IAGP)
abnormal response to transplant  (IAGP)
abnormal skin condition  (IAGP)
abnormal spleen B cell follicle morphology  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal T cell number  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
absent CD4-positive, alpha beta T cells  (IAGP)
absent CD8-positive, alpha-beta T cells  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cytotoxic T cell cytolysis  (IAGP)
decreased double-positive T cell number  (IAGP)
demyelination  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased CD8-positive, alpha-beta memory T cell proliferation  (IEA)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG2b level  (IAGP)
increased length of allograft survival  (IAGP)
increased monocyte cell number  (IAGP)
increased splenocyte number  (IAGP)
increased susceptibility to Herpesvirales infection  (IEA)
increased susceptibility to Picornaviridae infection  (IAGP)
increased susceptibility to systemic lupus erythematosus  (IAGP)
increased susceptibility to viral infection  (IAGP)
no abnormal phenotype detected  (IAGP)
premature death  (IAGP)
renal glomerular immunoglobulin deposits  (IAGP)
small thymus medulla  (IAGP)
References

Additional References at PubMed
PMID:75870   PMID:100557   PMID:1431091   PMID:1460424   PMID:1503636   PMID:1572667   PMID:1587551   PMID:1589800   PMID:1673361   PMID:1733847   PMID:1846950   PMID:1989904  
PMID:2165966   PMID:2341153   PMID:2410514   PMID:2459057   PMID:2493728   PMID:2613230   PMID:2783886   PMID:2784466   PMID:2824476   PMID:2843459   PMID:2875941   PMID:2878803  
PMID:2891029   PMID:2898504   PMID:2998983   PMID:3076405   PMID:3082651   PMID:3085089   PMID:3138071   PMID:3258885   PMID:3267233   PMID:3346044   PMID:3378837   PMID:3487583  
PMID:3495785   PMID:3817907   PMID:3919142   PMID:3927298   PMID:3935316   PMID:4353891   PMID:4385242   PMID:4547628   PMID:5021438   PMID:6122625   PMID:6275115   PMID:6437974  
PMID:6442265   PMID:6610701   PMID:6766165   PMID:7152259   PMID:7561076   PMID:7589126   PMID:7589135   PMID:7622189   PMID:7664803   PMID:7673704   PMID:7676644   PMID:7710778  
PMID:7911425   PMID:8018917   PMID:8064243   PMID:8075500   PMID:8100806   PMID:8223860   PMID:8225589   PMID:8228830   PMID:8419174   PMID:8423051   PMID:8453666   PMID:8500525  
PMID:8537123   PMID:8563173   PMID:8566069   PMID:8666829   PMID:8672138   PMID:8688082   PMID:8707416   PMID:8747923   PMID:8751373   PMID:8753864   PMID:8755570   PMID:8760788  
PMID:8788039   PMID:8805673   PMID:8920866   PMID:9126927   PMID:9126989   PMID:9197272   PMID:9208839   PMID:9218488   PMID:9285409   PMID:9314555   PMID:9414161   PMID:9551910  
PMID:9605173   PMID:9625767   PMID:9657273   PMID:9673288   PMID:9696828   PMID:9754575   PMID:9806635   PMID:9806636   PMID:9806638   PMID:9830036   PMID:9858522   PMID:9875336  
PMID:9894676   PMID:9973530   PMID:10072077   PMID:10072530   PMID:10199887   PMID:10222057   PMID:10229808   PMID:10229850   PMID:10349636   PMID:10369133   PMID:10377186   PMID:10427989  
PMID:10452966   PMID:10477580   PMID:10488058   PMID:10518215   PMID:10553054   PMID:10630289   PMID:10648399   PMID:10704459   PMID:10736089   PMID:10742150   PMID:10765562   PMID:10795739  
PMID:10846095   PMID:10919985   PMID:10926756   PMID:10943842   PMID:10946256   PMID:10966932   PMID:11006223   PMID:11042159   PMID:11046027   PMID:11076861   PMID:11114377   PMID:11120799  
PMID:11120841   PMID:11120867   PMID:11131152   PMID:11152110   PMID:11157050   PMID:11217851   PMID:11336693   PMID:11384990   PMID:11390490   PMID:11403253   PMID:11404381   PMID:11454058  
PMID:11486276   PMID:11489994   PMID:11535636   PMID:11696572   PMID:11719190   PMID:11729321   PMID:11741821   PMID:11754824   PMID:11929984   PMID:11937542   PMID:11937556   PMID:11943672  
PMID:11986258   PMID:12023391   PMID:12039909   PMID:12049715   PMID:12049716   PMID:12091326   PMID:12091350   PMID:12147624   PMID:12244138   PMID:12393413   PMID:12393459   PMID:12421964  
PMID:12429233   PMID:12466851   PMID:12477932   PMID:12502728   PMID:12504015   PMID:12574368   PMID:12626348   PMID:12695493   PMID:12810689   PMID:12816997   PMID:12946661   PMID:12960297  
PMID:14500656   PMID:14523041   PMID:14525595   PMID:14568922   PMID:14609575   PMID:14688352   PMID:14759595   PMID:14764722   PMID:14764728   PMID:15048111   PMID:15048712   PMID:15067052  
PMID:15067060   PMID:15078902   PMID:15096489   PMID:15105501   PMID:15128815   PMID:15153508   PMID:15210777   PMID:15240714   PMID:15254203   PMID:15258576   PMID:15262897   PMID:15294943  
PMID:15294958   PMID:15294964   PMID:15300247   PMID:15311278   PMID:15322158   PMID:15322214   PMID:15383569   PMID:15448711   PMID:15470028   PMID:15494509   PMID:15579444   PMID:15590890  
PMID:15606794   PMID:15634879   PMID:15637136   PMID:15661911   PMID:15699104   PMID:15699109   PMID:15699116   PMID:15699131   PMID:15728238   PMID:15728465   PMID:15728508   PMID:15729333  
PMID:15749886   PMID:15774618   PMID:15789339   PMID:15795238   PMID:15814727   PMID:15843532   PMID:15845464   PMID:15894262   PMID:15922720   PMID:15944248   PMID:15944263   PMID:15980863  
PMID:16002686   PMID:16014969   PMID:16051854   PMID:16113250   PMID:16141072   PMID:16141073   PMID:16155578   PMID:16177115   PMID:16203967   PMID:16210626   PMID:16237050   PMID:16237070  
PMID:16269570   PMID:16272340   PMID:16287714   PMID:16299293   PMID:16301680   PMID:16339567   PMID:16356863   PMID:16357940   PMID:16365422   PMID:16380545   PMID:16455951   PMID:16481417  
PMID:16491076   PMID:16493075   PMID:16513945   PMID:16530222   PMID:16552032   PMID:16552068   PMID:16621988   PMID:16621990   PMID:16717113   PMID:16849467   PMID:16872849   PMID:16879622  
PMID:16885234   PMID:16920915   PMID:16951356   PMID:16973387   PMID:16982903   PMID:17035062   PMID:17056525   PMID:17082573   PMID:17082577   PMID:17082623   PMID:17169429   PMID:17194734  
PMID:17204652   PMID:17213291   PMID:17224189   PMID:17253973   PMID:17255324   PMID:17277142   PMID:17301952   PMID:17307945   PMID:17357106   PMID:17412837   PMID:17460760   PMID:17475828  
PMID:17506031   PMID:17548647   PMID:17591956   PMID:17627890   PMID:17646404   PMID:17656648   PMID:17664264   PMID:17664294   PMID:17683113   PMID:17767161   PMID:17855564   PMID:17869640  
PMID:17873878   PMID:17878345   PMID:17923502   PMID:17950725   PMID:17954569   PMID:17956982   PMID:18023370   PMID:18184798   PMID:18337581   PMID:18408127   PMID:18424719   PMID:18426985  
PMID:18438414   PMID:18454133   PMID:18465769   PMID:18483277   PMID:18483278   PMID:18505782   PMID:18523287   PMID:18600823   PMID:18644885   PMID:18650384   PMID:18667491   PMID:18776904  
PMID:18799149   PMID:18836449   PMID:18929574   PMID:18952083   PMID:18984740   PMID:18997862   PMID:19004989   PMID:19009526   PMID:19052080   PMID:19060331   PMID:19079163   PMID:19088062  
PMID:19095793   PMID:19104149   PMID:19109142   PMID:19109193   PMID:19151321   PMID:19158156   PMID:19164596   PMID:19188497   PMID:19221040   PMID:19338001   PMID:19349303   PMID:19414746  
PMID:19414791   PMID:19449311   PMID:19528638   PMID:19542451   PMID:19597498   PMID:19625641   PMID:19641139   PMID:19647220   PMID:19710907   PMID:19723499   PMID:19838199   PMID:19898495  
PMID:19923446   PMID:19923462   PMID:19934022   PMID:19950178   PMID:20042455   PMID:20048124   PMID:20080755   PMID:20190135   PMID:20190758   PMID:20200356   PMID:20351189   PMID:20383150  
PMID:20404101   PMID:20404270   PMID:20639459   PMID:20679228   PMID:20709950   PMID:20956339   PMID:21115736   PMID:21135172   PMID:21157037   PMID:21160039   PMID:21178002   PMID:21179411  
PMID:21187449   PMID:21203525   PMID:21267068   PMID:21270396   PMID:21276089   PMID:21364747   PMID:21435585   PMID:21460847   PMID:21474667   PMID:21508411   PMID:21515796   PMID:21525388  
PMID:21536799   PMID:21559416   PMID:21572029   PMID:21629771   PMID:21630253   PMID:21704012   PMID:21873635   PMID:21911709   PMID:21949017   PMID:21964024   PMID:22025728   PMID:22036949  
PMID:22072979   PMID:22080947   PMID:22118527   PMID:22185976   PMID:22209676   PMID:22484915   PMID:22493083   PMID:22495988   PMID:22544940   PMID:22649199   PMID:22753943   PMID:22811544  
PMID:22862959   PMID:22865456   PMID:22893686   PMID:22908323   PMID:22928916   PMID:23079658   PMID:23209328   PMID:23297132   PMID:23306157   PMID:23307809   PMID:23311920   PMID:23447019  
PMID:23454765   PMID:23545296   PMID:23585675   PMID:23630275   PMID:23635775   PMID:23658704   PMID:23733879   PMID:23844100   PMID:23851682   PMID:23876314   PMID:24034254   PMID:24078696  
PMID:24114149   PMID:24293627   PMID:24297179   PMID:24347665   PMID:24480625   PMID:24600037   PMID:24610012   PMID:24614654   PMID:24657994   PMID:24675400   PMID:24681565   PMID:24695322  
PMID:24807710   PMID:24913977   PMID:24938765   PMID:25048196   PMID:25157823   PMID:25220211   PMID:25284152   PMID:25310588   PMID:25348153   PMID:25400914   PMID:25427562   PMID:25468565  
PMID:25519988   PMID:25536344   PMID:25548254   PMID:25769612   PMID:25770130   PMID:25916989   PMID:25924065   PMID:25977337   PMID:26070118   PMID:26114424   PMID:26314763   PMID:26379554  
PMID:26407316   PMID:26472910   PMID:26527008   PMID:26750596   PMID:26789248   PMID:27015456   PMID:27171004   PMID:27183639   PMID:27501245   PMID:27543048   PMID:27590114   PMID:27642729  
PMID:27653692   PMID:27653694   PMID:27671676   PMID:27686391   PMID:27739478   PMID:27827367   PMID:27872905   PMID:27920091   PMID:28017833   PMID:28064242   PMID:28202513   PMID:28371798  
PMID:28468970   PMID:28483582   PMID:28494873   PMID:28567448   PMID:28619948   PMID:28731407   PMID:28768726   PMID:28839093   PMID:28972091   PMID:29069606   PMID:29144460   PMID:29273790  
PMID:29515042   PMID:29590614   PMID:29894691   PMID:30111869   PMID:30381460   PMID:30397035   PMID:30674678   PMID:30962403   PMID:31909831   PMID:31974171   PMID:32102875   PMID:32268087  
PMID:32726802  


Genomics

Comparative Map Data
Cd8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39671,350,411 - 71,356,155 (+)NCBIGRCm39mm39
GRCm38671,373,427 - 71,379,171 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl671,373,427 - 71,379,173 (+)EnsemblGRCm38mm10GRCm38
MGSCv37671,323,421 - 71,329,165 (+)NCBIGRCm37mm9NCBIm37
MGSCv36671,302,936 - 71,308,680 (+)NCBImm8
Celera673,452,794 - 73,458,537 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.14NCBI
CD8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl286,784,610 - 86,808,396 (-)EnsemblGRCh38hg38GRCh38
GRCh38286,784,605 - 86,808,396 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37287,011,728 - 87,035,519 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36286,865,239 - 86,871,638 (-)NCBINCBI36hg18NCBI36
Build 34286,923,391 - 86,929,725NCBI
Celera286,839,534 - 86,863,331 (-)NCBI
Cytogenetic Map2p11.2NCBI
HuRef286,898,000 - 86,921,798 (-)NCBIHuRef
CHM1_1286,941,749 - 86,965,554 (-)NCBICHM1_1
Cd8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24103,365,804 - 103,370,041 (+)NCBI
Rnor_6.0 Ensembl499,239,115 - 99,243,351 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0499,217,640 - 99,243,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04163,993,814 - 164,022,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,589,922 - 104,594,159 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14104,834,402 - 104,838,639 (+)NCBI
Celera492,538,482 - 92,542,731 (+)NCBICelera
Cytogenetic Map4q31NCBI
Cd8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955424952,502 - 978,636 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955424952,595 - 979,159 (+)NCBIChiLan1.0ChiLan1.0
CD8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A88,376,411 - 88,383,519 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A88,377,722 - 88,382,635 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A86,832,559 - 86,855,772 (-)NCBIMhudiblu_PPA_v0panPan3
CD8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1738,369,414 - 38,400,508 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11738,396,022 - 38,400,508 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cd8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936712885,301 - 891,247 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl357,998,891 - 58,037,130 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1357,999,228 - 58,029,768 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2360,852,723 - 60,859,977 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD8A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11418,878,013 - 18,885,183 (+)NCBI
ChlSab1.1 Ensembl1418,878,622 - 18,883,885 (+)Ensembl
Cd8a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474916,564,944 - 16,569,890 (+)NCBI

Position Markers
BB154331  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38671,378,854 - 71,378,948UniSTSGRCm38
MGSCv37671,328,848 - 71,328,942UniSTSGRCm37
Celera673,458,220 - 73,458,314UniSTS
Cytogenetic Map6CUniSTS
cM Map630.5UniSTS
Whitehead/MRC_RH6715.05UniSTS
Y00157  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38671,377,375 - 71,377,574UniSTSGRCm38
MGSCv37671,327,369 - 71,327,568UniSTSGRCm37
Celera673,456,741 - 73,456,940UniSTS
Cytogenetic Map6CUniSTS
cM Map630.5UniSTS
Whitehead/MRC_RH6717.39UniSTS
Whitehead_YAC6 UniSTS
PMC122808P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38671,373,760 - 71,373,994UniSTSGRCm38
MGSCv37671,323,754 - 71,323,988UniSTSGRCm37
Celera673,453,127 - 73,453,361UniSTS
Cytogenetic Map6CUniSTS
cM Map630.5UniSTS
Cd8a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38671,374,771 - 71,374,871UniSTSGRCm38
MGSCv37671,324,765 - 71,324,865UniSTSGRCm37
Celera673,454,138 - 73,454,238UniSTS
Cytogenetic Map6CUniSTS
cM Map630.5UniSTS
Y00157  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38671,377,376 - 71,377,510UniSTSGRCm38
MGSCv37671,327,370 - 71,327,504UniSTSGRCm37
Celera673,456,742 - 73,456,876UniSTS
Cytogenetic Map6CUniSTS
Whitehead/MRC_RH6717.39UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414873387692Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3285065078238974Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64089129671379171Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64160000075600000Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64211637376116515Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64211637376116515Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64211637376116515Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64211637376116515Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64382681377811523Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64382681377811523Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64382681377811523Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64382681377811523Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64382681377811523Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64382681377811523Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
4140983Srilp_msleep response to influenza, light phase (mouse)Not determined4872655675447710Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1233
Count of miRNA genes:436
Interacting mature miRNAs:507
Transcripts:ENSMUST00000066747, ENSMUST00000172321
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001081110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC160090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ131778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK037467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M22064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U34881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000066747   ⟹   ENSMUSP00000068123
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl671,373,427 - 71,379,169 (+)Ensembl
RefSeq Acc Id: ENSMUST00000172321   ⟹   ENSMUSP00000131873
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl671,373,553 - 71,379,173 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205054
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl671,373,548 - 71,377,607 (+)Ensembl
RefSeq Acc Id: NM_001081110   ⟹   NP_001074579
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39671,350,411 - 71,356,155 (+)NCBI
GRCm38671,373,427 - 71,379,171 (+)NCBI
MGSCv37671,323,421 - 71,329,165 (+)RGD
Celera673,452,794 - 73,458,537 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_009857   ⟹   NP_033987
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39671,350,411 - 71,356,155 (+)NCBI
GRCm38671,373,427 - 71,379,171 (+)NCBI
MGSCv37671,323,421 - 71,329,165 (+)RGD
Celera673,452,794 - 73,458,537 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001074579   ⟸   NM_001081110
- Peptide Label: isoform 1 precursor
- UniProtKB: P01731 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_033987   ⟸   NM_009857
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8CAX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000068123   ⟸   ENSMUST00000066747
RefSeq Acc Id: ENSMUSP00000131873   ⟸   ENSMUST00000172321
Protein Domains
Ig-like   Ig-like V-type

Promoters
RGD ID:6850396
Promoter ID:EP17097
Type:single initiation site
Name:MM_CD8A
Description:T-cell differentiation antigen, CD8A or LYT2 Oor LYT-2 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Nuclease protection with homologous sequence ladder
Regulation:immature, cytotoxic, suppressor T (repressed by or weakly expressed in) cells
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv37671,323,214 - 71,323,274EPD
MGSCv36671,323,214 - 71,323,274EPD
RGD ID:6889962
Promoter ID:EPDNEW_M8432
Type:preliminary
Name:Cd8a_2
Description:Mus musculus CD8 antigen, alpha chain , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8433  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38671,373,220 - 71,373,280EPDNEW
RGD ID:6889964
Promoter ID:EPDNEW_M8433
Type:initiation region
Name:Cd8a_1
Description:Mus musculus CD8 antigen, alpha chain , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8432  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38671,373,548 - 71,373,608EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88346 AgrOrtholog
Ensembl Genes ENSMUSG00000053977 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000068123 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000131873 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000066747 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000172321 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD8_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12525 UniProtKB/Swiss-Prot
MGD MGI:88346 ENTREZGENE
NCBI Gene 12525 ENTREZGENE
PANTHER PTHR10441 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd8a PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CD8A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UUV7_MOUSE UniProtKB/TrEMBL
  Q542K6_MOUSE UniProtKB/TrEMBL
  Q60965_MOUSE UniProtKB/TrEMBL
  Q8C2L1_MOUSE UniProtKB/TrEMBL
  Q8C2Q0_MOUSE UniProtKB/TrEMBL
  Q8CAX3 ENTREZGENE, UniProtKB/TrEMBL
  Q8K2M2_MOUSE UniProtKB/TrEMBL