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Gene: Cd8a (CD8 antigen, alpha chain) Mus musculus
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Symbol: Cd8a
Name: CD8 antigen, alpha chain
Description: Exhibits identical protein binding activity. Involved in several processes, including cytotoxic T cell differentiation; defense response to virus; and positive regulation of calcium-mediated signaling. Localizes to the external side of plasma membrane. Is expressed in several structures, including endocrine gland; exocrine gland; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human CD8A (CD8a molecule); PARTICIPATES IN interleukin-12 signaling pathway; antigen processing and presentation pathway; primary immunodeficiency pathway; INTERACTS WITH (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BB154331; Ly-2; Ly-35; Ly-B; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2
Orthologs:
Homo sapiens (human) : CD8A (CD8a molecule)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd8a (CD8a molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd8a (CD8a molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD8A (CD8a molecule)
Canis lupus familiaris (dog) : CD8A (CD8a molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd8a (CD8a molecule)
Sus scrofa (pig) : CD8A (CD8a molecule)
Chlorocebus sabaeus (green monkey) : CD8A (CD8a molecule)
Heterocephalus glaber (naked mole-rat) : Cd8a (CD8a molecule)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl671,373,427 - 71,379,173 (+)Ensembl
GRCm38671,373,427 - 71,379,171 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37671,323,421 - 71,329,165 (+)NCBIGRCm37mm9NCBIm37
MGSCv36671,302,936 - 71,308,680 (+)NCBImm8
Celera673,452,794 - 73,458,537 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cd8a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10317
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.