Brca2 (breast cancer 2, early onset) - Rat Genome Database

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Gene: Brca2 (breast cancer 2, early onset) Mus musculus
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Symbol: Brca2
Name: breast cancer 2, early onset
RGD ID: 10247
MGI Page MGI
Description: Predicted to enable several functions, including gamma-tubulin binding activity; histone acetyltransferase activity; and protein C-terminus binding activity. Involved in several processes, including establishment of protein localization to telomere; male meiosis I; and telomere maintenance via recombination. Acts upstream of or within several processes, including DNA metabolic process; gamete generation; and signal transduction by p53 class mediator. Located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and hemolymphoid system gland. Used to study Fanconi anemia complementation group D1 and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); brain cancer (multiple); hereditary breast ovarian cancer syndrome; melanoma (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA2 (BRCA2 DNA repair associated); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ceramide signaling pathway; pancreatic cancer pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dichloroethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI256696; AW045498; breast cancer 2; breast cancer type 2 susceptibility protein homolog; Fanc; Fancd1; fanconi anemia group D1 protein homolog; RAB1; RAB163
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395150,445,759 - 150,493,612 (+)NCBIGRCm39mm39
GRCm39 Ensembl5150,446,095 - 150,493,794 (+)Ensembl
GRCm385150,522,297 - 150,570,147 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5150,522,630 - 150,570,329 (+)EnsemblGRCm38mm10GRCm38
MGSCv375151,325,198 - 151,372,324 (+)NCBIGRCm37mm9NCBIm37
MGSCv365150,791,554 - 150,838,126 (+)NCBImm8
Celera5148,527,149 - 148,574,274 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model