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Gene: Psen1 (presenilin 1) Mus musculus
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Symbol: Psen1
Name: presenilin 1
Description: Exhibits cadherin binding activity and endopeptidase activity. Involved in several processes, including animal organ development; nervous system development; and regulation of cellular protein metabolic process. Localizes to several cellular components, including the ciliary rootlet; dendritic shaft; and growth cone. Predicted to colocalize with the smooth endoplasmic reticulum. Used to study Alzheimer's disease and Alzheimer's disease 3. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1U; frontotemporal dementia; hidradenitis suppurativa; and neurodegenerative disease (multiple). Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and respiratory system. Orthologous to human PSEN1 (presenilin 1); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ad3h; presenilin-1; PS-1; PS1; S182
Orthologs:
Homo sapiens (human) : PSEN1 (presenilin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Psen1 (presenilin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Psen1 (presenilin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PSEN1 (presenilin 1)
Canis lupus familiaris (dog) : PSEN1 (presenilin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Psen1 (presenilin 1)
Sus scrofa (pig) : PSEN1 (presenilin 1)
Chlorocebus sabaeus (green monkey) : PSEN1 (presenilin 1)
Heterocephalus glaber (naked mole-rat) : Psen1 (presenilin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1283,688,152 - 83,735,199 (+)Ensembl
GRCm381283,688,152 - 83,735,095 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371285,029,513 - 85,076,149 (+)NCBIGRCm37mm9NCBIm37
MGSCv361284,578,311 - 84,624,947 (+)NCBImm8
Celera1285,135,054 - 85,181,689 (+)NCBICelera
Cytogenetic Map12 D1NCBI
cM Map1238.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Psen1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735973
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.