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Gene: Psen1 (presenilin 1) Mus musculus
Symbol: Psen1
Name: presenilin 1
Description: Exhibits cadherin binding activity and endopeptidase activity. Involved in several processes, including animal organ development; nervous system development; and regulation of cellular protein metabolic process. Localizes to several cellular components, including the ciliary rootlet; dendritic shaft; and growth cone. Predicted to colocalize with the smooth endoplasmic reticulum. Used to study Alzheimer's disease and Alzheimer's disease 3. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1U; frontotemporal dementia; hidradenitis suppurativa; and neurodegenerative disease (multiple). Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and respiratory system. Orthologous to human PSEN1 (presenilin 1); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ad3h; presenilin-1; PS-1; PS1; S182
Homo sapiens (human) : PSEN1 (presenilin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Psen1 (presenilin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Psen1 (presenilin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PSEN1 (presenilin 1)
Canis lupus familiaris (dog) : PSEN1 (presenilin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Psen1 (presenilin 1)
Sus scrofa (pig) : PSEN1 (presenilin 1)
Chlorocebus sabaeus (green monkey) : PSEN1 (presenilin 1)
Heterocephalus glaber (naked mole-rat) : Psen1 (presenilin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1283,688,152 - 83,735,199 (+)Ensembl
GRCm381283,688,152 - 83,735,095 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371285,029,513 - 85,076,149 (+)NCBIGRCm37mm9NCBIm37
MGSCv361284,578,311 - 84,624,947 (+)NCBImm8
Celera1285,135,054 - 85,181,689 (+)NCBICelera
Cytogenetic Map12 D1NCBI
cM Map1238.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Psen1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735973
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.