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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473
Species: Mus musculus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Acc ID: CHEBI:30314
Term: (R)-lipoic acid
Definition: The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties.
Chemical ID: MESH:D008063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases activityISONqo1 (Rattus norvegicus)6480464CTDThioctic Acid results in increased activity of NQO1 proteinPMID:12180195
Nqo1increases activityISONQO1 (Homo sapiens)6480464CTDThioctic Acid results in increased activity of NQO1 proteinPMID:17940886
Nqo1increases expressionISONqo1 (Rattus norvegicus)6480464CTDThioctic Acid results in increased expression of NQO1 mRNA; Thioctic Acid results in increased expression of NQO1 proteinPMID:12180195
Nqo1increases expressionISONQO1 (Homo sapiens)6480464CTDThioctic Acid results in increased expression of NQO1 mRNA; Thioctic Acid results in increased expression of NQO1 proteinPMID:17940886 PMID:19033392 PMID:23649336 PMID:30758914 PMID:31319135
Nqo1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]PMID:23830814 PMID:31068541
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTD[Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein]PMID:23649336 PMID:30758914 PMID:31319135
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