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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulindac sulfide
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Accession:CHEBI:75408 term browser browse the term
Definition:An aryl sulfide that is a metabolite of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity.
Synonyms:exact_synonym: {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfanyl)benzylidene]-1H-inden-3-yl}acetic acid
 related_synonym: Formula=C20H17FO2S;   InChI=1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-;   InChIKey=LFWHFZJPXXOYNR-MFOYZWKCSA-N;   SMILES=CSc1ccc(cc1)\\C=C1\\C(C)=C(CC(O)=O)c2cc(F)ccc12
 xref: CAS:49627-27-2;   HMDB:HMDB0060614
 xref_mesh: MESH:C025462
 xref: PDBeChem:SFI;   PMID:21458423;   PMID:21991341;   PMID:23202471;   PMID:23280445;   PMID:23443799;   Patent:JP2005247807;   Patent:NZ336035;   Reaxys:2950058


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sulindac sulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO sulindac sulfide results in increased expression of ABCG2 mRNA CTD PMID:16184548 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Actn1 actinin, alpha 1 decreases expression ISO sulindac sulfide results in decreased expression of ACTN1 mRNA CTD PMID:16184548 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 decreases expression ISO sulindac sulfide results in decreased expression of ADAM9 mRNA CTD PMID:16184548 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917 		JBrowse link
G Adm adrenomedullin increases expression ISO sulindac sulfide results in increased expression of ADM mRNA CTD PMID:16184548 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Adra2c adrenoceptor alpha 2C decreases expression ISO sulindac sulfide results in decreased expression of ADRA2C mRNA CTD PMID:12734198 NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Ahr aryl hydrocarbon receptor increases localization ISO sulindac sulfide results in increased localization of AHR protein CTD PMID:17985343 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akap12 A-kinase anchoring protein 12 increases expression ISO sulindac sulfide results in increased expression of AKAP12 mRNA CTD PMID:12734198 NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO sulindac sulfide results in increased expression of AKR1C1 mRNA CTD PMID:16184548 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO sulindac sulfide results in decreased expression of ALDOC mRNA CTD PMID:16184548 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression ISO sulindac sulfide results in increased expression of ALOX15 protein CTD PMID:16166323 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Anxa5 annexin A5 increases expression ISO sulindac sulfide results in increased expression of ANXA5 protein CTD PMID:18678619 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO sulindac sulfide inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein] CTD PMID:19013290 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G App amyloid beta precursor protein multiple interactions
affects cleavage		 ISO
EXP		 [sulindac sulfide results in decreased activity of PSEN1 protein] which affects the cleavage of APP protein; PSEN1 protein affects the reaction [sulindac sulfide affects the cleavage of APP protein]; PSEN1 protein mutant form promotes the reaction [sulindac sulfide affects the cleavage of APP protein]; sulindac sulfide affects the cleavage of and affects the localization of APP protein; sulindac sulfide affects the reaction [PSEN1 protein affects the cleavage of APP protein]
sulindac sulfide inhibits the reaction [APP protein results in increased uptake of Calcium]		 CTD PMID:11700559 PMID:12637581 PMID:12777371 PMID:12805356 PMID:14690522 More... NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Ar androgen receptor multiple interactions ISO AR protein affects the reaction [sulindac sulfide results in decreased expression of KLK3 protein]; sulindac sulfide results in decreased expression of and results in decreased activity of AR protein CTD PMID:14581372 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Areg amphiregulin increases expression ISO sulindac sulfide results in increased expression of AREG mRNA CTD PMID:16184548 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Arl6ip1 ARL6 interacting reticulophagy regulator 1 decreases expression ISO sulindac sulfide results in decreased expression of ARL6IP1 mRNA CTD PMID:12734198 NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994 		JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B decreases expression ISO sulindac sulfide results in decreased expression of ARPC1B mRNA CTD PMID:12734198 NCBI chr12:9,482,176...9,495,772
Ensembl chr12:9,480,831...9,495,747 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 decreases expression ISO sulindac sulfide results in decreased expression of ASAH1 mRNA CTD PMID:16184548 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of ATF3 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of ATF3 protein; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; MAP2K1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]
sulindac sulfide results in increased expression of ATF3 mRNA; sulindac sulfide results in increased expression of ATF3 protein		 CTD PMID:12734198 PMID:15897233 PMID:16079301 PMID:16184548 PMID:21554132 More... NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 increases expression ISO sulindac sulfide results in increased expression of ATP6V0A1 mRNA CTD PMID:16184548 NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895 		JBrowse link
G Aurka aurora kinase A decreases expression ISO sulindac sulfide results in decreased expression of AURKA mRNA CTD PMID:12734198 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
multiple interactions
increases localization		 ISO sulindac sulfide results in decreased expression of BAD protein
[sulindac sulfide results in decreased expression of YWHAE protein] which results in increased localization of BAD protein; sulindac sulfide promotes the reaction [BAD protein binds to YWHAE protein]
sulindac sulfide results in increased localization of BAD protein		 CTD PMID:17409426 PMID:18678619 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases response to substance EXP BAK1 results in increased susceptibility to sulindac sulfide CTD PMID:18349538 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects response to substance
decreases expression
increases expression		 ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]
BAX protein affects the susceptibility to sulindac sulfide
sulindac sulfide results in decreased expression of BAX protein
sulindac sulfide results in increased expression of BAX mRNA		 CTD PMID:12203115 PMID:16886631 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcam basal cell adhesion molecule (Lutheran blood group) decreases expression ISO sulindac sulfide results in decreased expression of BCAM mRNA CTD PMID:12734198 NCBI chr 1:79,415,016...79,429,403
Ensembl chr 1:79,415,017...79,429,403 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases phosphorylation ISO sulindac sulfide results in decreased phosphorylation of BCAR1 protein CTD PMID:10741720 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sulindac sulfide results in decreased expression of BCL2 protein CTD PMID:18678619 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO sulindac sulfide results in decreased expression of BCL2L1 protein CTD PMID:11912124 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression
increases cleavage		 ISO sulindac sulfide results in decreased expression of BID protein
sulindac sulfide results in increased cleavage of BID protein		 CTD PMID:12203115 PMID:16886631 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO sulindac sulfide results in increased expression of BIRC3 mRNA CTD PMID:16184548 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO sulindac sulfide results in decreased expression of BUB1B mRNA CTD PMID:16184548 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
G Cacng3 calcium voltage-gated channel auxiliary subunit gamma 3 increases expression ISO sulindac sulfide results in increased expression of CACNG3 mRNA CTD PMID:16184548 NCBI chr 1:177,201,361...177,297,019
Ensembl chr 1:177,201,288...177,297,024 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression		 ISO sulindac sulfide results in increased activity of CASP3 protein
[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; MAP2K1 protein inhibits the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP3 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]
sulindac sulfide results in increased expression of CASP3 mRNA		 CTD PMID:11051267 PMID:12203115 PMID:12414664 PMID:14555707 PMID:15548677 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein] CTD PMID:20371263 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP8 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:11559570 PMID:12203115 PMID:12414664 PMID:16886631 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP9 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein] CTD PMID:12203115 PMID:12414664 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 increases expression ISO sulindac sulfide results in increased expression of CCAR1 mRNA CTD PMID:12734198 NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
increases expression		 ISO sulindac sulfide results in decreased expression of CCN2 mRNA
sulindac sulfide results in increased expression of CCN2 mRNA		 CTD PMID:12734198 PMID:16184548 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of CCND1 protein]
sulindac sulfide results in decreased expression of CCND1 mRNA; sulindac sulfide results in decreased expression of CCND1 protein		 CTD PMID:14710233 PMID:15188006 PMID:15767558 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd4 Cd4 molecule increases expression ISO sulindac sulfide results in increased expression of CD4 mRNA CTD PMID:12734198 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Cd46 CD46 molecule decreases expression ISO sulindac sulfide results in decreased expression of CD46 mRNA CTD PMID:16184548 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO sulindac sulfide results in increased expression of and results in increased activity of CDH1 protein CTD PMID:12391285 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh17 cadherin 17 decreases expression ISO sulindac sulfide results in decreased expression of CDH17 mRNA CTD PMID:16184548 NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
affects activity		 ISO PPARD protein inhibits the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; PPARG protein promotes the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]
sulindac sulfide results in increased expression of CDKN1A mRNA; sulindac sulfide results in increased expression of CDKN1A protein
sulindac sulfide affects the activity of CDKN1A protein		 CTD PMID:15694660 PMID:15767558 PMID:16091736 PMID:16184548 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO sulindac sulfide results in increased expression of CEBPB mRNA; sulindac sulfide results in increased expression of CEBPB protein CTD PMID:12734198 PMID:16184548 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO sulindac sulfide results in decreased expression of CFLAR protein CTD PMID:11912124 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Clp1 cleavage factor polyribonucleotide kinase subunit 1 decreases expression ISO sulindac sulfide results in decreased expression of CLP1 mRNA CTD PMID:12734198 NCBI chr 3:69,806,774...69,818,633
Ensembl chr 3:69,806,778...69,810,421 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO sulindac sulfide results in increased expression of CRYAB mRNA CTD PMID:16184548 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of CTNNB1 protein]; sulindac sulfide affects the localization of and results in decreased expression of CTNNB1 protein; sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of CCND1 protein]; sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of MET protein]; sulindac sulfide results in decreased expression of and results in decreased localization of CTNNB1 protein CTD PMID:14555707 PMID:14710233 PMID:15188006 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsc cathepsin C decreases expression ISO sulindac sulfide results in decreased expression of CTSC mRNA CTD PMID:16184548 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Cyb5b cytochrome b5 type B decreases expression ISO sulindac sulfide results in decreased expression of CYB5B mRNA CTD PMID:12734198 NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO sulindac sulfide results in increased expression of CYP1A1 mRNA CTD PMID:12734198 PMID:16184548 PMID:17985343 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO sulindac sulfide results in increased expression of CYP1A2 mRNA CTD PMID:17985343 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO sulindac sulfide results in increased expression of CYP1B1 mRNA CTD PMID:12734198 PMID:17985343 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Dcbld2 discoidin, CUB and LCCL domain containing 2 increases expression ISO sulindac sulfide results in increased expression of DCBLD2 mRNA CTD PMID:12734198 NCBI chr11:42,125,525...42,179,927
Ensembl chr11:42,125,787...42,179,697 		JBrowse link
G Ddx11 DEAD/H-box helicase 11 decreases expression ISO sulindac sulfide results in decreased expression of DDX11 mRNA CTD PMID:16184548 NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO sulindac sulfide results in decreased expression of DHCR24 mRNA CTD PMID:16184548 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO sulindac sulfide results in decreased expression of DHCR7 mRNA CTD PMID:16184548 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Dynll1 dynein light chain LC8-type 1 decreases expression ISO sulindac sulfide results in decreased expression of DYNLL1 mRNA CTD PMID:12734198 NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases phosphorylation
increases phosphorylation
increases ubiquitination
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]
sulindac sulfide results in decreased phosphorylation of EGFR protein
sulindac sulfide results in increased phosphorylation of EGFR protein
sulindac sulfide results in increased ubiquitination of EGFR protein		 CTD PMID:20332299 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression		 ISO EGR1 protein affects the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of GDF15 mRNA]; ELK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]
sulindac sulfide results in increased expression of EGR1 mRNA; sulindac sulfide results in increased expression of EGR1 protein		 CTD PMID:15509713 PMID:16079301 PMID:16227405 PMID:17599376 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; ELK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; sulindac sulfide results in increased phosphorylation of and affects the activity of ELK1 protein; U 0126 inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein] CTD PMID:17599376 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of ERBB2 protein] CTD PMID:20332299 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of ERBB3 protein] CTD PMID:20332299 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 affects cleavage ISO sulindac sulfide affects the cleavage of ERBB4 protein CTD PMID:12777371 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Esd esterase D increases expression ISO sulindac sulfide results in increased expression of ESD mRNA CTD PMID:12734198 NCBI chr15:50,043,634...50,063,134
Ensembl chr15:50,043,632...50,063,144 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO sulindac sulfide results in decreased expression of ESR1 mRNA; sulindac sulfide results in decreased expression of ESR1 protein CTD PMID:16740773 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression ISO sulindac sulfide results in decreased expression of ETFB mRNA CTD PMID:16184548 NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068 		JBrowse link
G Etnppl ethanolamine-phosphate phospho-lyase increases expression ISO sulindac sulfide results in increased expression of ETNPPL mRNA CTD PMID:12734198 NCBI chr 2:219,173,048...219,194,646
Ensembl chr 2:219,172,978...219,192,212 		JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions
increases expression		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [sulindac sulfide analog results in increased expression of FABP1 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP1 protein] CTD PMID:17602619 PMID:18665581 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [sulindac sulfide analog results in increased expression of FABP4 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP4 protein] CTD PMID:17602619 PMID:18665581 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fcgrt Fc gamma receptor and transporter decreases expression ISO sulindac sulfide results in decreased expression of FCGRT mRNA CTD PMID:16184548 NCBI chr 1:95,574,436...95,584,171
Ensembl chr 1:95,567,175...95,584,084 		JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression ISO sulindac sulfide results in decreased expression of FDPS mRNA CTD PMID:16184548 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 decreases expression ISO sulindac sulfide results in decreased expression of FGFR4 mRNA CTD PMID:16184548 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing
increases metabolic processing		 ISO FMO3 gene polymorphism affects the metabolism of sulindac sulfide
FMO3 protein results in increased metabolism of sulindac sulfide		 CTD PMID:17142560 PMID:17559352 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Foxm1 forkhead box M1 decreases expression ISO sulindac sulfide results in decreased expression of FOXM1 mRNA CTD PMID:16184548 NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684 		JBrowse link
G Gal3st4 galactose-3-O-sulfotransferase 4 decreases expression ISO sulindac sulfide results in decreased expression of GAL3ST4 mRNA CTD PMID:16184548 NCBI chr12:17,267,963...17,276,951
Ensembl chr12:17,267,963...17,276,833 		JBrowse link
G Gars1 glycyl-tRNA synthetase 1 increases expression ISO sulindac sulfide results in increased expression of GARS1 mRNA CTD PMID:12734198 NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609 		JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions
increases expression		 ISO EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of GDF15 mRNA]
sulindac sulfide results in increased expression of GDF15 mRNA; sulindac sulfide results in increased expression of GDF15 protein		 CTD PMID:11895857 PMID:11925476 PMID:12734198 PMID:15180942 PMID:15509713 More... NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gk glycerol kinase increases expression ISO sulindac sulfide results in increased expression of GK mRNA CTD PMID:16184548 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631 		JBrowse link
G Glcci1 glucocorticoid induced 1 increases expression ISO sulindac sulfide results in increased expression of GLCCI1 mRNA CTD PMID:16184548 NCBI chr 4:36,307,956...36,635,614
Ensembl chr 4:36,307,903...36,635,612 		JBrowse link
G Grn granulin precursor decreases expression ISO sulindac sulfide results in decreased expression of GRN mRNA CTD PMID:16184548 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO sulindac sulfide binds to and results in decreased activity of GSTP1 protein CTD PMID:15300575 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO sulindac sulfide results in decreased expression of HDAC1 mRNA CTD PMID:16184548 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO sulindac sulfide results in decreased expression of HGF mRNA CTD PMID:10807402 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hm13 histocompatibility minor 13 affects binding
multiple interactions		 ISO sulindac sulfide binds to HM13 protein
sulindac sulfide inhibits the reaction [L 685458 binds to HM13 protein]		 CTD PMID:17932033 NCBI chr 3:141,145,792...141,183,557
Ensembl chr 3:141,145,782...141,184,703 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO sulindac sulfide results in decreased expression of HSD3B1 mRNA CTD PMID:16184548 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO sulindac sulfide results in increased expression of HSPA1B mRNA CTD PMID:16184548 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO sulindac sulfide results in increased expression of HSPA6 mRNA CTD PMID:16184548 NCBI chr13:83,273,176...83,274,317 JBrowse link
G Icam2 intercellular adhesion molecule 2 increases expression ISO sulindac sulfide results in increased expression of ICAM2 mRNA CTD PMID:16184548 NCBI chr10:91,308,608...91,319,536
Ensembl chr10:91,308,538...91,315,293 		JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO sulindac sulfide results in decreased expression of ID1 mRNA; sulindac sulfide results in decreased expression of ID1 protein CTD PMID:16184548 PMID:21554132 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 decreases expression ISO sulindac sulfide results in decreased expression of IFITM1 mRNA CTD PMID:16184548 NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169 		JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 decreases expression ISO sulindac sulfide results in decreased expression of IFITM3 mRNA CTD PMID:16184548 NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO sulindac sulfide results in increased expression of IFRD1 mRNA CTD PMID:12734198 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases activity ISO sulindac sulfide results in decreased activity of IKBKB protein CTD PMID:11912124 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 decreases expression ISO sulindac sulfide results in decreased expression of IL13RA1 mRNA CTD PMID:16184548 NCBI chr  X:115,348,822...115,408,682
Ensembl chr  X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases expression ISO sulindac sulfide results in increased expression of IL1R1 mRNA CTD PMID:16184548 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Ilf3 interleukin enhancer binding factor 3 decreases expression ISO sulindac sulfide results in decreased expression of ILF3 mRNA CTD PMID:16184548 NCBI chr 8:19,922,409...19,960,495
Ensembl chr 8:19,922,460...19,960,350 		JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO sulindac sulfide results in decreased expression of INSIG1 mRNA CTD PMID:12734198 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression ISO sulindac sulfide results in increased expression of ISG20 mRNA CTD PMID:16184548 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO sulindac sulfide results in decreased expression of ITPR1 mRNA CTD PMID:15767558 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Jag2 jagged canonical Notch ligand 2 increases expression ISO sulindac sulfide results in increased expression of JAG2 mRNA CTD PMID:16184548 NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO sulindac sulfide results in increased expression of JUN mRNA CTD PMID:16704987 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kalrn kalirin, RhoGEF kinase decreases expression ISO sulindac sulfide results in decreased expression of KALRN mRNA CTD PMID:16184548 NCBI chr11:66,198,155...66,803,166
Ensembl chr11:66,198,173...66,797,610 		JBrowse link
G Klhl21 kelch-like family member 21 increases expression ISO sulindac sulfide results in increased expression of KLHL21 mRNA CTD PMID:16184548 NCBI chr 5:162,514,888...162,523,545
Ensembl chr 5:162,514,765...162,523,545 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 decreases expression
multiple interactions		 ISO sulindac sulfide results in decreased expression of KLK3 protein
AR protein affects the reaction [sulindac sulfide results in decreased expression of KLK3 protein]		 CTD PMID:14581372 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Krt14 keratin 14 increases expression ISO sulindac sulfide results in increased expression of KRT14 mRNA CTD PMID:16184548 NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt16 keratin 16 increases expression ISO sulindac sulfide results in increased expression of KRT16 mRNA CTD PMID:16184548 NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt17 keratin 17 increases expression ISO sulindac sulfide results in increased expression of KRT17 mRNA CTD PMID:16184548 NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392 		JBrowse link
G Krt19 keratin 19 decreases expression ISO sulindac sulfide results in decreased expression of KRT19 mRNA CTD PMID:12734198 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt5 keratin 5 decreases expression ISO sulindac sulfide results in decreased expression of KRT5 mRNA CTD PMID:12734198 NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850 		JBrowse link
G Lamc1 laminin subunit gamma 1 increases expression
decreases expression		 ISO sulindac sulfide results in increased expression of LAMC1 mRNA
sulindac sulfide results in decreased expression of LAMC1 protein		 CTD PMID:15561105 PMID:16184548 NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 decreases expression ISO sulindac sulfide results in decreased expression of LAMP1 mRNA CTD PMID:16184548 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO sulindac sulfide results in decreased expression of LDHA mRNA CTD PMID:12734198 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO sulindac sulfide results in decreased expression of LDLR mRNA CTD PMID:16184548 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO sulindac sulfide results in decreased expression of MAD2L1 mRNA; sulindac sulfide results in decreased expression of MAD2L1 protein CTD PMID:12734198 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 increases expression ISO sulindac sulfide results in increased expression of MAGI1 mRNA CTD PMID:12734198 NCBI chr 4:126,205,663...126,811,354
Ensembl chr 4:126,206,816...126,811,691 		JBrowse link
G Mal mal, T-cell differentiation protein decreases expression ISO sulindac sulfide results in decreased expression of MAL mRNA CTD PMID:16184548 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136 		JBrowse link
G Man2b2 mannosidase, alpha, class 2B, member 2 increases expression ISO sulindac sulfide results in increased expression of MAN2B2 mRNA CTD PMID:12734198 NCBI chr14:73,969,079...73,994,089
Ensembl chr14:73,969,003...74,004,281 		JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor increases expression ISO sulindac sulfide results in increased expression of MANF mRNA CTD PMID:16184548 NCBI chr 8:107,500,856...107,551,595
Ensembl chr 8:107,548,352...107,551,438 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; MAP2K1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA] CTD PMID:15548677 PMID:16079301 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO sulindac sulfide results in decreased expression of MAP3K1 mRNA CTD PMID:12734198 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of ATF3 protein; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of THBS1 protein; MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK1 protein]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; sulindac sulfide results in increased phosphorylation of and affects the activity of MAPK1 protein CTD PMID:15548677 PMID:16079301 PMID:17599376 PMID:18261746 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO sulindac sulfide results in increased expression of MAPK10 mRNA CTD PMID:12734198 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of ATF3 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of THBS1 protein; MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK3 protein]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; sulindac sulfide results in increased phosphorylation of and affects the activity of MAPK3 protein CTD PMID:15548677 PMID:16079301 PMID:17599376 PMID:18261746 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO sulindac sulfide results in increased activity of MAPK8 protein CTD PMID:11051267 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mars2 methionyl-tRNA synthetase 2, mitochondrial increases expression ISO sulindac sulfide results in increased expression of MARS2 mRNA CTD PMID:16184548 NCBI chr 9:56,720,408...56,729,991
Ensembl chr 9:56,720,983...56,723,820 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO sulindac sulfide results in decreased expression of MCM2 mRNA CTD PMID:16184548 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of MET protein] CTD PMID:14710233 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression
increases expression		 ISO sulindac sulfide results in decreased expression of MMP1 mRNA
sulindac sulfide results in increased expression of MMP1 mRNA		 CTD PMID:15767558 PMID:16184548 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO sulindac sulfide results in increased expression of MMP10 mRNA CTD PMID:16184548 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748 		JBrowse link
G Mras muscle RAS oncogene homolog increases expression ISO sulindac sulfide results in increased expression of MRAS mRNA CTD PMID:16184548 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO sulindac sulfide results in decreased expression of MSMO1 mRNA CTD PMID:12734198 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Msx1 msh homeobox 1 decreases expression ISO sulindac sulfide results in decreased expression of MSX1 mRNA; sulindac sulfide results in decreased expression of MSX1 protein CTD PMID:12734198 NCBI chr14:72,961,036...72,964,970
Ensembl chr14:72,961,148...72,964,966 		JBrowse link
G Mtfr1 mitochondrial fission regulator 1 increases expression ISO sulindac sulfide results in increased expression of MTFR1 mRNA CTD PMID:16184548 NCBI chr 2:101,678,331...101,713,547
Ensembl chr 2:101,679,265...101,713,544 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase increases expression ISO sulindac sulfide results in increased expression of MTHFD2 mRNA CTD PMID:12734198 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Muc1 mucin 1, cell surface associated decreases expression ISO sulindac sulfide results in decreased expression of MUC1 mRNA CTD PMID:16184548 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO sulindac sulfide results in decreased expression of MX1 mRNA CTD PMID:16184548 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507 		JBrowse link
G Myh10 myosin heavy chain 10 increases expression ISO sulindac sulfide results in increased expression of MYH10 mRNA CTD PMID:12734198 NCBI chr10:53,393,901...53,525,174
Ensembl chr10:53,394,389...53,525,165 		JBrowse link
G Ncapd3 non-SMC condensin II complex, subunit D3 decreases expression ISO sulindac sulfide results in decreased expression of NCAPD3 mRNA CTD PMID:16184548 NCBI chr 8:25,437,067...25,506,375
Ensembl chr 8:25,437,123...25,506,373 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases activity ISO sulindac sulfide results in decreased activity of NFKB1 protein CTD PMID:12085227 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO sulindac sulfide results in decreased phosphorylation of NFKBIA protein CTD PMID:12085227 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Niban1 niban apoptosis regulator 1 increases expression ISO sulindac sulfide results in increased expression of NIBAN1 mRNA CTD PMID:12734198 NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression		 ISO sulindac sulfide results in increased activity of NQO1 protein
sulindac sulfide results in increased expression of NQO1 mRNA		 CTD PMID:17985343 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nup133 nucleoporin 133 increases expression ISO sulindac sulfide results in increased expression of NUP133 mRNA CTD PMID:12734198 NCBI chr19:51,891,606...51,941,243
Ensembl chr19:51,891,629...51,941,239 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression ISO sulindac sulfide results in increased expression of ODC1 mRNA CTD PMID:16184548 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
decreases expression		 ISO (4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid promotes the reaction [sulindac sulfide results in increased cleavage of PARP1 protein]
sulindac sulfide results in decreased expression of PARP1 mRNA		 CTD PMID:12663503 PMID:16184548 PMID:16886631 PMID:18678619 PMID:21400612 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pawr pro-apoptotic WT1 regulator increases expression ISO sulindac sulfide results in increased expression of PAWR mRNA CTD PMID:10833474 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 decreases expression ISO sulindac sulfide results in decreased expression of PCSK9 mRNA CTD PMID:16184548 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression ISO sulindac sulfide results in decreased expression of PGAM1 mRNA CTD PMID:12734198 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452 		JBrowse link
G Pgr progesterone receptor decreases expression ISO sulindac sulfide results in decreased expression of PGR mRNA; sulindac sulfide results in decreased expression of PGR protein CTD PMID:16740773 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO sulindac sulfide results in decreased expression of PKM mRNA CTD PMID:16184548 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO sulindac sulfide results in decreased expression of PLAU mRNA CTD PMID:15767558 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO sulindac sulfide results in increased expression of PMAIP1 mRNA CTD PMID:16184548 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit decreases expression ISO sulindac sulfide results in decreased expression of POLD3 mRNA CTD PMID:16184548 NCBI chr 1:154,417,893...154,456,687
Ensembl chr 1:154,418,084...154,456,665 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO sulindac sulfide results in increased expression of PPARA mRNA CTD PMID:11948457 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions
decreases expression
decreases activity
increases expression		 ISO PPARD protein affects the reaction [sulindac sulfide results in decreased expression of YWHAE protein]; PPARD protein inhibits the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; sulindac sulfide binds to and results in decreased activity of PPARD protein
sulindac sulfide results in decreased expression of PPARD mRNA; sulindac sulfide results in decreased expression of PPARD protein
sulindac sulfide results in decreased activity of PPARD protein
sulindac sulfide results in increased expression of PPARD mRNA; sulindac sulfide results in increased expression of PPARD protein		 CTD PMID:10555149 PMID:11948457 PMID:16091736 PMID:17409426 PMID:18678619 More... NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
affects binding
increases activity
increases expression		 ISO [sulindac sulfide results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP1 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP4 protein]; PPARG protein promotes the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; sulindac sulfide analog binds to and results in increased activity of PPARG protein; sulindac sulfide analog inhibits the reaction [troglitazone binds to PPARG protein]; sulindac sulfide binds to and results in increased activity of PPARG protein
sulindac sulfide analog binds to PPARG protein
sulindac sulfide results in increased expression of PPARG mRNA		 CTD PMID:10866999 PMID:11948457 PMID:16091736 PMID:17602619 PMID:18665581 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha decreases expression ISO sulindac sulfide results in decreased expression of PPP2R1A mRNA CTD PMID:12734198 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 decreases expression ISO sulindac sulfide results in decreased expression of PPT1 mRNA CTD PMID:16184548 NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Prep prolyl endopeptidase increases expression ISO sulindac sulfide results in increased expression of PREP mRNA CTD PMID:12734198 NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression ISO sulindac sulfide results in increased expression of PRKACA mRNA CTD PMID:16184548 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prkcsh PRKCSH beta subunit of glucosidase II decreases expression ISO sulindac sulfide results in decreased expression of PRKCSH mRNA CTD PMID:16184548 NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492 		JBrowse link
G Prrx1 paired related homeobox 1 decreases expression ISO sulindac sulfide results in decreased expression of PRRX1 mRNA CTD PMID:16184548 NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866 		JBrowse link
G Prss23 serine protease 23 decreases expression ISO sulindac sulfide results in decreased expression of PRSS23 mRNA CTD PMID:12734198 NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091 		JBrowse link
G Psen1 presenilin 1 decreases response to substance
multiple interactions
decreases activity		 ISO PSEN1 gene mutant form results in decreased susceptibility to sulindac sulfide
[sulindac sulfide results in decreased activity of PSEN1 protein] which affects the cleavage of APP protein; PSEN1 protein affects the reaction [sulindac sulfide affects the cleavage of APP protein]; PSEN1 protein mutant form promotes the reaction [sulindac sulfide affects the cleavage of APP protein]; sulindac sulfide affects the reaction [PSEN1 protein affects the cleavage of APP protein]		 CTD PMID:12805356 PMID:17573346 PMID:17962197 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 decreases expression ISO sulindac sulfide results in decreased expression of PSMC2 mRNA CTD PMID:16184548 NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185 		JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 affects binding
multiple interactions		 ISO sulindac sulfide binds to PTGDR2 protein
[sulindac sulfide binds to PTGDR2 protein] which results in decreased abundance of Cyclic AMP; sulindac sulfide inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]		 CTD PMID:15563582 NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO sulindac sulfide results in decreased activity of PTGS1 protein CTD PMID:11245490 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases response to substance
decreases activity
increases expression		 ISO [sulindac sulfide results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP3 protein]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP8 protein]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP9 protein]; sulindac sulfide inhibits the reaction [PTGS2 protein results in decreased expression of TNFRSF10B mRNA]; sulindac sulfide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
PTGS2 protein results in increased susceptibility to sulindac sulfide
sulindac sulfide results in decreased activity of PTGS2 protein
sulindac sulfide results in increased expression of PTGS2 mRNA; sulindac sulfide results in increased expression of PTGS2 protein		 CTD PMID:10485483 PMID:10866999 PMID:11245490 PMID:11948457 PMID:12208739 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO sulindac sulfide results in decreased phosphorylation of PTK2 protein CTD PMID:10741720 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F decreases expression ISO sulindac sulfide results in decreased expression of PTPRF mRNA CTD PMID:16184548 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023 		JBrowse link
G Pvt1 Pvt1 oncogene increases expression ISO sulindac sulfide results in increased expression of PVT1 mRNA CTD PMID:12734198 NCBI chr 7:93,656,528...93,879,938 JBrowse link
G Ranbp1 RAN binding protein 1 increases expression ISO sulindac sulfide results in increased expression of RANBP1 mRNA CTD PMID:12734198 NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838 		JBrowse link
G Rap1gap Rap1 GTPase-activating protein increases expression ISO sulindac sulfide results in increased expression of RAP1GAP mRNA CTD PMID:12734198 NCBI chr 5:149,873,987...149,939,254
Ensembl chr 5:149,892,019...149,939,253 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects activity ISO sulindac sulfide affects the activity of RB1 protein CTD PMID:15694660 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Recql4 RecQ like helicase 4 decreases expression ISO sulindac sulfide results in decreased expression of RECQL4 mRNA CTD PMID:16184548 NCBI chr 7:108,423,453...108,430,790
Ensembl chr 7:108,423,455...108,430,619 		JBrowse link
G Reg1a regenerating family member 1 alpha decreases expression ISO sulindac sulfide results in decreased expression of REG1A mRNA CTD PMID:16184548 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity ISO sulindac sulfide results in decreased activity of RELA protein CTD PMID:11912124 PMID:12085227 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rere arginine-glutamic acid dipeptide repeats decreases expression ISO sulindac sulfide results in decreased expression of RERE mRNA CTD PMID:12734198 NCBI chr 5:160,765,855...161,097,678
Ensembl chr 5:160,765,934...161,097,677 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO sulindac sulfide results in increased expression of RGS16 mRNA CTD PMID:16184548 NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [sulindac sulfide results in increased activity of RHOA protein] which results in increased expression of THBS1 protein; RHOA protein promotes the reaction [sulindac sulfide results in increased expression of THBS1 protein] CTD PMID:18261746 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO sulindac sulfide results in decreased expression of RRM2 mRNA CTD PMID:12734198 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G Rrs1 ribosome biogenesis regulator 1 homolog increases expression ISO sulindac sulfide results in increased expression of RRS1 mRNA CTD PMID:12734198 NCBI chr 5:9,733,486...9,735,119
Ensembl chr 5:9,733,091...9,735,140 		JBrowse link
G Serpinb5 serpin family B member 5 decreases expression ISO sulindac sulfide results in decreased expression of SERPINB5 mRNA CTD PMID:15897233 NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO sulindac sulfide results in increased expression of SERPINE1 mRNA CTD PMID:15897233 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO sulindac sulfide results in decreased expression of SKP2 mRNA CTD PMID:16184548 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Slc25a1 solute carrier family 25 member 1 decreases expression ISO sulindac sulfide results in decreased expression of SLC25A1 mRNA CTD PMID:16184548 NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781 		JBrowse link
G Slc25a45 solute carrier family 25, member 45 increases expression ISO sulindac sulfide results in increased expression of SLC25A45 mRNA CTD PMID:12734198 NCBI chr 1:203,166,362...203,174,473
Ensembl chr 1:203,166,683...203,174,473 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO sulindac sulfide results in increased expression of SLC3A2 mRNA CTD PMID:16184548 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Sprr1b small proline-rich protein 1B increases expression ISO sulindac sulfide results in increased expression of SPRR1B mRNA CTD PMID:16184548 NCBI chr 2:178,008,844...178,010,742
Ensembl chr 2:178,009,130...178,009,567 		JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 decreases expression ISO sulindac sulfide results in decreased expression of SPTBN1 mRNA CTD PMID:12734198 NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO sulindac sulfide results in increased expression of SQSTM1 mRNA CTD PMID:16184548 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 decreases expression ISO sulindac sulfide results in decreased expression of SREBF2 mRNA CTD PMID:16184548 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression		 ISO sulindac sulfide results in decreased expression of and results in decreased phosphorylation of STAT3 protein
sulindac sulfide results in decreased expression of STAT3 mRNA		 CTD PMID:17566705 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO sulindac sulfide results in increased expression of STC2 mRNA CTD PMID:12734198 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973 		JBrowse link
G Stk17b serine/threonine kinase 17b increases expression ISO sulindac sulfide results in increased expression of STK17B mRNA CTD PMID:16184548 NCBI chr 9:55,307,485...55,338,085
Ensembl chr 9:55,307,668...55,338,031 		JBrowse link
G Syde1 synapse defective Rho GTPase homolog 1 increases expression ISO sulindac sulfide results in increased expression of SYDE1 mRNA CTD PMID:12734198 NCBI chr 7:11,032,931...11,038,917
Ensembl chr 7:11,032,898...11,039,869 		JBrowse link
G Tfap2b transcription factor AP-2 beta increases expression ISO sulindac sulfide results in increased expression of TFAP2B mRNA CTD PMID:16184548 NCBI chr 9:21,786,251...21,816,054
Ensembl chr 9:21,786,258...21,814,520 		JBrowse link
G Tff3 trefoil factor 3 decreases expression ISO sulindac sulfide results in decreased expression of TFF3 mRNA CTD PMID:16184548 NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054 		JBrowse link
G Thbs1 thrombospondin 1 multiple interactions
increases expression		 ISO [sulindac sulfide results in increased activity of RHOA protein] which results in increased expression of THBS1 protein; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of THBS1 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of THBS1 protein; EGR1 protein affects the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; RHOA protein promotes the reaction [sulindac sulfide results in increased expression of THBS1 protein]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 protein]
sulindac sulfide results in increased expression of THBS1 mRNA; sulindac sulfide results in increased expression of THBS1 protein		 CTD PMID:16227405 PMID:18261746 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO sulindac sulfide results in decreased expression of TK1 mRNA CTD PMID:16184548 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920 		JBrowse link
G Tmpo thymopoietin decreases expression ISO sulindac sulfide results in decreased expression of TMPO mRNA CTD PMID:16184548 NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727 		JBrowse link
G Tmsb4x thymosin beta 4, X-linked decreases expression ISO sulindac sulfide results in decreased expression of TMSB4X mRNA CTD PMID:15292456 NCBI chr  X:27,144,666...27,146,667
Ensembl chr  X:27,128,610...27,146,667 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein; [sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein; sulindac sulfide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein] CTD PMID:10866999 PMID:20371263 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO sulindac sulfide results in increased expression of TNFRSF10A mRNA; sulindac sulfide results in increased expression of TNFRSF10A protein CTD PMID:15180942 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein] CTD PMID:12203115 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO sulindac sulfide results in decreased expression of TP53 protein CTD PMID:9192825 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trip4 thyroid hormone receptor interactor 4 increases expression ISO sulindac sulfide results in increased expression of TRIP4 mRNA CTD PMID:16184548 NCBI chr 8:66,351,861...66,439,679
Ensembl chr 8:66,353,248...66,439,774 		JBrowse link
G Tspan8 tetraspanin 8 decreases expression ISO sulindac sulfide results in decreased expression of TSPAN8 mRNA CTD PMID:16184548 NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356 		JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression ISO sulindac sulfide results in decreased expression of TUBA4A mRNA CTD PMID:12734198 NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO sulindac sulfide results in increased expression of TXNRD1 mRNA CTD PMID:16184548 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Uba7 ubiquitin-like modifier activating enzyme 7 decreases expression ISO sulindac sulfide results in decreased expression of UBA7 mRNA CTD PMID:16184548 NCBI chr 8:108,665,289...108,674,097
Ensembl chr 8:108,665,292...108,674,099 		JBrowse link
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 increases expression ISO sulindac sulfide results in increased expression of UBE2D1 mRNA CTD PMID:16184548 NCBI chr20:17,309,315...17,343,770
Ensembl chr20:17,309,315...17,342,295 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity
increases expression		 ISO sulindac sulfide results in increased activity of UGT1A1 protein
sulindac sulfide results in increased expression of UGT1A1 mRNA		 CTD PMID:17985343 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO sulindac sulfide results in increased expression of UPP1 mRNA CTD PMID:16184548 NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462 		JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO sulindac sulfide results in increased expression of VMP1 mRNA CTD PMID:12734198 NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 increases expression ISO sulindac sulfide results in increased expression of XRCC6 mRNA CTD PMID:12734198 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon multiple interactions
decreases expression		 ISO [sulindac sulfide results in decreased expression of YWHAE protein] which results in increased localization of BAD protein; PPARD protein affects the reaction [sulindac sulfide results in decreased expression of YWHAE protein]; sulindac sulfide promotes the reaction [BAD protein binds to YWHAE protein]
sulindac sulfide results in decreased expression of YWHAE mRNA; sulindac sulfide results in decreased expression of YWHAE protein		 CTD PMID:17409426 PMID:18678619 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        biochemical role 19571
          apoptosis inducer 13666
            sulindac sulfide 219
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbon oxoacid 18675
                                    carboxylic acid 18672
                                      monocarboxylic acid 18017
                                        acetic acid 11094
                                          sulindac 787
                                            sulindac sulfide 219
paths to the root