Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulindac
go back to main search page
Accession:CHEBI:9352 term browser browse the term
Definition:A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.
Synonyms:exact_synonym: {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
 related_synonym: (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid;   Clinoril;   Formula=C20H17FO3S;   InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-;   InChIKey=MLKXDPUZXIRXEP-MFOYZWKCSA-N;   SMILES=CC1=C(CC(O)=O)c2cc(F)ccc2C\\1=C/c1ccc(cc1)S(C)=O;   Sulindacum;   cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid;   cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid;   sulindaco
 xref: Beilstein:2951842;   CAS:38194-50-2;   DrugBank:DB00605;   Drug_Central:2534;   HMDB:HMDB0014743;   KEGG:C01531;   KEGG:D00120
 xref_mesh: MESH:D013467
 xref: PDBeChem:SUZ;   PMID:11569947;   PMID:11927004;   PMID:12406542;   PMID:15020200;   PMID:15123337;   PMID:19884509;   PMID:23689354;   PMID:23804703;   Patent:DE2039426;   Patent:US3654349;   Reaxys:2951842;   Wikipedia:Sulindac


show annotations for term's descendants           Sort by:
 
sulindac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 increases expression
multiple interactions
ISO Sulindac results in increased expression of ABCC1 protein
Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC1 protein]
CTD PMID:11820781 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC3 protein] CTD PMID:11820781 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 increases expression EXP Sulindac results in increased expression of ABCD3 mRNA CTD PMID:24136188 NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020
JBrowse link
G Abhd16a abhydrolase domain containing 16A, phospholipase increases expression EXP Sulindac results in increased expression of ABHD16A mRNA CTD PMID:24136188 NCBI chr20:3,719,089...3,733,952
Ensembl chr20:3,719,091...3,733,927
JBrowse link
G Abi1 abl-interactor 1 decreases expression EXP Sulindac results in decreased expression of ABI1 mRNA CTD PMID:24136188 NCBI chr17:85,098,837...85,179,829
Ensembl chr17:85,098,550...85,179,792
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression ISO Sulindac results in increased expression of ACACA mRNA CTD PMID:32535746 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ACAD9 mRNA CTD PMID:20371263 NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO
EXP
Sulindac results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acly ATP citrate lyase increases expression ISO Sulindac results in increased expression of ACLY mRNA CTD PMID:32535746 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acp2 acid phosphatase 2, lysosomal increases expression ISO Sulindac results in increased expression of ACP2 mRNA CTD PMID:11906190 NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ACSL1 mRNA CTD PMID:20371263 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Actr10 actin related protein 10 decreases expression EXP Sulindac results in decreased expression of ACTR10 mRNA CTD PMID:24136188 NCBI chr 6:89,446,141...89,472,350
Ensembl chr 6:89,446,093...89,473,047
JBrowse link
G Acy1 aminoacylase 1 increases expression EXP Sulindac results in increased expression of ACY1 mRNA CTD PMID:24136188 NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682
JBrowse link
G Add1 adducin 1 increases expression EXP Sulindac results in increased expression of ADD1 mRNA CTD PMID:24136188 NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182
JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ADHFE1 mRNA CTD PMID:20371263 NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517
JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ADIPOR2 mRNA CTD PMID:20371263 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Adss adenylosuccinate synthase increases expression EXP Sulindac results in increased expression of ADSS mRNA CTD PMID:24136188 NCBI chr13:89,769,240...89,799,577
Ensembl chr13:89,769,244...89,799,604
JBrowse link
G Ahr aryl hydrocarbon receptor increases localization
multiple interactions
ISO
EXP
Sulindac results in increased localization of AHR protein
Sulindac binds to and results in increased activity of AHR protein
CTD PMID:16531450 PMID:17985343 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aif1l allograft inflammatory factor 1-like decreases expression ISO Sulindac results in decreased expression of AIF1L mRNA CTD PMID:11906190 NCBI chr 3:15,229,476...15,254,033
Ensembl chr 3:15,229,524...15,254,023
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO Sulindac affects the localization of AIFM1 protein CTD PMID:15946692 PMID:17136320 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 increases expression ISO Sulindac results in increased expression of AIFM2 mRNA CTD PMID:11906190 NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236
JBrowse link
G Akap1 A-kinase anchoring protein 1 increases expression EXP Sulindac results in increased expression of AKAP1 mRNA CTD PMID:24136188 NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896
JBrowse link
G Akap9 A-kinase anchoring protein 9 decreases expression EXP Sulindac results in decreased expression of AKAP9 mRNA CTD PMID:24136188 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO Sulindac analog binds to and results in decreased activity of AKR1B1 protein; Sulindac binds to and results in decreased activity of AKR1B1 protein CTD PMID:25532697 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO Sulindac analog binds to and results in decreased activity of AKR1B10 protein; Sulindac binds to and results in decreased activity of AKR1B10 protein CTD PMID:25532697 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Sulindac results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Sulindac results in decreased activity of AKR1C3 protein CTD PMID:19010312 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
[AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]] which affects the susceptibility to Oxygen; AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]
[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of AKT1 mRNA
Sulindac analog results in decreased phosphorylation of AKT1 protein
CTD PMID:18924134 PMID:20371263 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt1s1 AKT1 substrate 1 decreases expression EXP Sulindac results in decreased expression of AKT1S1 mRNA CTD PMID:24136188 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases expression
increases expression
ISO
EXP
Sulindac results in decreased expression of AKT2 mRNA
Sulindac results in increased expression of AKT2 mRNA
CTD PMID:11906190 PMID:24136188 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Alb albumin multiple interactions EXP [Sulindac co-treated with REN2] results in increased expression of ALB protein CTD PMID:12586211 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH1A1 mRNA CTD PMID:20371263 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH1L1 mRNA CTD PMID:20371263 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression EXP Sulindac results in decreased expression of ALDH3A2 mRNA CTD PMID:24136188 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH6A1 mRNA CTD PMID:20371263 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
JBrowse link
G Alg14 ALG14, UDP-N-acetylglucosaminyltransferase subunit increases expression EXP Sulindac results in increased expression of ALG14 mRNA CTD PMID:24136188 NCBI chr 2:209,368,285...209,445,425
Ensembl chr 2:209,368,312...209,445,431
JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression
multiple interactions
increases activity
ISO Sulindac results in increased expression of ALOX15 protein
[Sulindac results in increased expression of ALOX15 protein] which results in increased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid
Sulindac results in increased activity of ALOX15 protein
CTD PMID:10904086 PMID:11406566 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Sulindac promotes the reaction [cobaltous chloride results in decreased expression of ALPL protein]; Sulindac promotes the reaction [Deferoxamine results in decreased expression of ALPL protein] CTD PMID:21882223 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 multiple interactions ISO [Sulindac co-treated with Putrescine] results in decreased activity of AMD1 protein CTD PMID:17474863 NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476
JBrowse link
G Amt aminomethyltransferase increases expression EXP Sulindac results in increased expression of AMT mRNA CTD PMID:24136188 NCBI chr 8:108,981,620...108,988,127
Ensembl chr 8:108,976,472...108,988,126
JBrowse link
G Amz2 archaelysin family metallopeptidase 2 decreases expression EXP Sulindac results in decreased expression of AMZ2 mRNA CTD PMID:24136188 NCBI chr10:94,401,546...94,412,116
Ensembl chr10:94,401,579...94,412,114
JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO Sulindac results in decreased expression of ANGPTL3 mRNA CTD PMID:32535746 NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957
JBrowse link
G Ankrd11 ankyrin repeat domain 11 increases expression ISO Sulindac results in increased expression of ANKRD11 mRNA CTD PMID:11906190 NCBI chr19:50,940,284...51,098,962
Ensembl chr19:50,940,299...51,098,962
JBrowse link
G Ankrd24 ankyrin repeat domain 24 increases expression EXP Sulindac results in increased expression of ANKRD24 mRNA CTD PMID:24136188 NCBI chr 7:8,061,634...8,081,142
Ensembl chr 7:8,061,953...8,081,142
JBrowse link
G Ankrd28 ankyrin repeat domain 28 decreases expression EXP Sulindac results in decreased expression of ANKRD28 mRNA CTD PMID:24136188 NCBI chr16:6,918,487...7,050,244
Ensembl chr16:6,914,336...7,050,249
JBrowse link
G Ap1ar adaptor-related protein complex 1 associated regulatory protein increases expression EXP Sulindac results in increased expression of AP1AR mRNA CTD PMID:24136188 NCBI chr 2:216,276,631...216,309,020
Ensembl chr 2:216,276,631...216,309,013
JBrowse link
G Ap3d1 adaptor related protein complex 3 subunit delta 1 increases expression EXP Sulindac results in increased expression of AP3D1 mRNA CTD PMID:24136188 NCBI chr 7:8,970,249...9,005,651
Ensembl chr 7:8,970,291...9,005,643
JBrowse link
G Apc APC regulator of WNT signaling pathway multiple interactions
increases expression
EXP Sulindac inhibits the reaction [Azoxymethane results in decreased expression of APC mRNA]
Sulindac results in increased expression of APC protein
CTD PMID:11076880 PMID:12458338 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Apob apolipoprotein B decreases secretion ISO Sulindac results in decreased secretion of APOB protein CTD PMID:32535746 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoc3 apolipoprotein C3 decreases secretion ISO Sulindac results in decreased secretion of APOC3 protein CTD PMID:32535746 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of APP mRNA] CTD PMID:15190207 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP Sulindac results in decreased expression of AQP1 mRNA CTD PMID:24136188 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Arglu1 arginine and glutamate rich 1 increases expression ISO Sulindac results in increased expression of ARGLU1 mRNA CTD PMID:11906190 NCBI chr16:80,753,300...80,777,350
Ensembl chr16:80,753,315...80,777,349
JBrowse link
G Arid1b AT-rich interaction domain 1B decreases expression EXP Sulindac results in decreased expression of ARID1B mRNA CTD PMID:24136188 NCBI chr 1:45,567,991...45,923,644
Ensembl chr 1:45,563,623...45,923,493
JBrowse link
G Arl1 ADP-ribosylation factor like GTPase 1 increases expression EXP Sulindac results in increased expression of ARL1 mRNA CTD PMID:24136188 NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898
JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO Sulindac results in increased expression of ARRDC3 mRNA CTD PMID:11906190 NCBI chr 2:11,137,443...11,149,978
Ensembl chr 2:11,137,460...11,149,978
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Sulindac results in increased expression of ASNS mRNA CTD PMID:11906190 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Asnsd1 asparagine synthetase domain containing 1 increases expression EXP Sulindac results in increased expression of ASNSD1 mRNA CTD PMID:24136188 NCBI chr 9:48,126,802...48,139,073
Ensembl chr 9:48,126,808...48,139,073
JBrowse link
G Ate1 arginyltransferase 1 decreases expression EXP Sulindac results in decreased expression of ATE1 mRNA CTD PMID:24136188 NCBI chr 1:184,961,548...185,081,112
Ensembl chr 1:184,963,562...185,080,908
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Sulindac results in increased expression of ATF3 mRNA CTD PMID:11906190 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Sulindac results in increased expression of ATF4 mRNA CTD PMID:11906190 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Sulindac results in increased expression of ATF6 mRNA CTD PMID:32535746 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atg3 autophagy related 3 increases expression EXP Sulindac results in increased expression of ATG3 mRNA CTD PMID:24136188 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 decreases expression ISO Sulindac results in decreased expression of ATP2A1 mRNA CTD PMID:11906190 NCBI chr 1:181,026,606...181,044,859 JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A increases expression EXP Sulindac results in increased expression of ATP6V1A mRNA CTD PMID:24136188 NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694
JBrowse link
G Atp6v1e1 ATPase H+ transporting V1 subunit E1 increases expression EXP Sulindac results in increased expression of ATP6V1E1 mRNA CTD PMID:24136188 NCBI chr 4:154,022,360...154,044,486
Ensembl chr 4:154,022,358...154,044,584
JBrowse link
G Auh AU RNA binding methylglutaconyl-CoA hydratase multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of AUH mRNA CTD PMID:20371263 NCBI chr17:12,329,522...12,424,896
Ensembl chr17:12,329,524...12,424,896
JBrowse link
G Aurka aurora kinase A decreases expression ISO Sulindac results in decreased expression of AURKA mRNA CTD PMID:11906190 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Aurkaip1 aurora kinase A interacting protein 1 decreases expression EXP Sulindac results in decreased expression of AURKAIP1 mRNA CTD PMID:24136188 NCBI chr 5:166,435,177...166,436,888
Ensembl chr 5:166,417,508...166,436,882
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 decreases expression EXP Sulindac results in decreased expression of B4GALT1 mRNA CTD PMID:24136188 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases expression
ISO Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of BAD protein]
Sulindac results in decreased expression of BAD protein
CTD PMID:12566304 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
affects localization
ISO SB 203580 inhibits the reaction [Sulindac affects the localization of BAK1 protein] CTD PMID:17136320 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects localization
increases response to substance
ISO SB 203580 inhibits the reaction [Sulindac affects the localization of BAX protein]
Sulindac results in increased expression of BAX protein
BAX protein results in increased susceptibility to Sulindac
CTD PMID:11062132 PMID:17136320 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Sulindac results in increased expression of BBC3 mRNA CTD PMID:11906190 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcap29 B-cell receptor-associated protein 29 increases expression ISO Sulindac results in increased expression of BCAP29 mRNA CTD PMID:11906190 NCBI chr 6:48,182,702...48,222,698
Ensembl chr 6:48,182,706...48,222,720
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Sulindac results in decreased expression of BCL2 protein
[Olive Oil co-treated with Sulindac] results in decreased expression of BCL2 protein
[Sulindac results in increased abundance of Reactive Oxygen Species] which results in increased cleavage of BCL2 protein
CTD PMID:10223192 PMID:15309441 PMID:15793875 PMID:17136320 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO [Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein; Acetylcysteine inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein]; MAPK8 affects the reaction [[Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein]
Sulindac results in decreased expression of BCL2L1 protein
CTD PMID:11062132 PMID:18281123 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of BIRC2 protein CTD PMID:17136320 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO [Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of BIRC3 protein CTD PMID:17136320 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO [Sulindac co-treated with Arsenic Trioxide] results in decreased expression of BIRC5 protein; [Sulindac co-treated with Vorinostat] results in decreased expression of BIRC5 mRNA; [Sulindac co-treated with Vorinostat] results in decreased expression of BIRC5 protein; [Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of BIRC5 protein; BIRC5 protein inhibits the reaction [Sulindac results in decreased expression of STAT3 protein modified form]; BIRC5 protein inhibits the reaction [Sulindac results in decreased expression of STAT3 protein]
Sulindac results in decreased expression of BIRC5 mRNA; Sulindac results in decreased expression of BIRC5 protein
CTD PMID:11906190 PMID:14610217 PMID:17136320 PMID:17401459 PMID:18156316 More... NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Blmh bleomycin hydrolase increases expression EXP Sulindac results in increased expression of BLMH mRNA CTD PMID:24136188 NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression EXP Sulindac results in increased expression of BNIP3L mRNA CTD PMID:24136188 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Borcs7 BLOC-1 related complex subunit 7 increases expression EXP Sulindac results in increased expression of BORCS7 mRNA CTD PMID:24136188 NCBI chr 1:245,564,347...245,578,182
Ensembl chr 1:245,564,369...245,579,343
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO Sulindac results in decreased expression of BRCA1 mRNA CTD PMID:16273229 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brd4 bromodomain containing 4 decreases expression ISO Sulindac results in decreased expression of BRD4 mRNA CTD PMID:11906190 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
JBrowse link
G Btbd1 BTB domain containing 1 increases expression EXP Sulindac results in increased expression of BTBD1 mRNA CTD PMID:24136188 NCBI chr 1:135,734,549...135,773,067
Ensembl chr 1:135,734,589...135,771,981
JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 increases expression EXP Sulindac results in increased expression of BZW1 mRNA CTD PMID:24136188 NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
JBrowse link
G Bzw2 basic leucine zipper and W2 domains 2 decreases expression ISO Sulindac results in decreased expression of BZW2 mRNA CTD PMID:11093808 NCBI chr 6:52,828,069...52,888,599
Ensembl chr 6:52,827,661...52,888,628
JBrowse link
G C1galt1c1 C1GALT1-specific chaperone 1 decreases expression EXP Sulindac results in decreased expression of C1GALT1C1 mRNA CTD PMID:24136188 NCBI chr  X:117,378,123...117,382,620
Ensembl chr  X:117,375,525...117,382,787
JBrowse link
G C4b complement C4B (Chido blood group) decreases expression EXP Sulindac results in decreased expression of C4B mRNA CTD PMID:24136188 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G Ca9 carbonic anhydrase 9 decreases expression ISO Sulindac analog results in decreased expression of CA9 mRNA CTD PMID:18924134 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Calm3 calmodulin 3 decreases expression
increases expression
ISO
EXP
Sulindac results in decreased expression of CALM3 mRNA
Sulindac results in increased expression of CALM3 mRNA
CTD PMID:11906190 PMID:24136188 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
ISO
EXP
[Sulindac co-treated with arsenic trioxide] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased activity of CASP3 protein]
epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]]; Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]
Sulindac results in increased activity of CASP3 protein
[Sulindac results in increased expression of IL24 protein] which results in increased expression of CASP3 protein
CTD PMID:12017300 PMID:15713900 PMID:15946692 PMID:18281123 PMID:29999212 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Sulindac co-treated with TNFSF10 protein] results in increased activity of CASP8 protein CTD PMID:21171083 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity
ISO [Sulindac co-treated with arsenic trioxide] results in increased activity of CASP9 protein
[Sulindac results in increased expression of IL24 protein] which results in increased expression of CASP9 protein
Sulindac results in increased activity of CASP9 protein
CTD PMID:15713900 PMID:18281123 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cast calpastatin decreases expression EXP Sulindac results in decreased expression of CAST mRNA CTD PMID:24136188 NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659
JBrowse link
G Cavin3 caveolae associated protein 3 increases expression ISO Sulindac results in increased expression of CAVIN3 mRNA CTD PMID:11906190 NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Sulindac inhibits the reaction [IL1B protein results in increased expression of CCL5 mRNA]; Sulindac inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA] CTD PMID:16159934 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Sulindac results in decreased expression of CCNA2 protein CTD PMID:16488075 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Sulindac results in decreased expression of CCNB1 mRNA CTD PMID:11906190 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO CTNNB1 protein affects the reaction [Sulindac results in decreased expression of CCND1 protein]; Sulindac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
[Sulindac co-treated with Plant Extracts] results in decreased expression of CCND1 protein
CTD PMID:11504793 PMID:11593435 PMID:12351151 PMID:12584176 PMID:15020200 More... NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Sulindac results in decreased expression of CCNE1 protein CTD PMID:16488075 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccnj cyclin J decreases expression ISO Sulindac results in decreased expression of CCNJ mRNA CTD PMID:11906190 NCBI chr 1:239,659,588...239,677,367 JBrowse link
G Ccnq cyclin Q decreases expression EXP Sulindac results in decreased expression of CCNQ mRNA CTD PMID:24136188 NCBI chr10:63,646,532...63,647,695
Ensembl chr10:63,646,527...63,647,961
JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 decreases expression EXP Sulindac results in decreased expression of CCT4 mRNA CTD PMID:24136188 NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267
JBrowse link
G Ccz1b CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated increases expression EXP Sulindac results in increased expression of CCZ1B mRNA CTD PMID:24136188 NCBI chr12:10,601,066...10,624,608
Ensembl chr12:10,601,056...10,624,608
JBrowse link
G Cdc37l1 cell division cycle 37-like 1 decreases expression EXP Sulindac results in decreased expression of CDC37L1 mRNA CTD PMID:24136188 NCBI chr 1:226,705,019...226,733,994
Ensembl chr 1:226,705,003...226,761,175
JBrowse link
G Cdc42ep1 CDC42 effector protein 1 increases expression ISO Sulindac results in increased expression of CDC42EP1 mRNA CTD PMID:11906190 NCBI chr 7:110,395,287...110,403,203
Ensembl chr 7:110,395,332...110,403,200
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Sulindac results in decreased expression of CDK1 mRNA CTD PMID:16273229 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases activity
ISO Sulindac promotes the reaction [CDKN1A protein results in decreased activity of CDK2 protein]
Sulindac results in decreased activity of CDK2 protein
CTD PMID:14566837 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO
EXP
CTNNB1 protein affects the reaction [Sulindac results in decreased expression of CDK4 protein]
[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CDK4 mRNA
CTD PMID:17292881 PMID:18291362 PMID:20371263 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Sulindac results in decreased expression of CDK6 protein CTD PMID:16488075 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
increases response to substance
increases activity
decreases activity
ISO
EXP
[Sulindac co-treated with epigallocatechin gallate] results in increased expression of CDKN1A mRNA; CDKN1A protein promotes the reaction [Sulindac results in increased expression of and results in increased phosphorylation of MAPK8 protein]; CSK protein affects the reaction [Sulindac results in increased expression of CDKN1A protein]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of APP mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of CTSB mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GBA mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GRN mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of IL32 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of ITGB3 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3BP mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SAA1 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SHC1 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SOD2 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of TGM2 mRNA]; Sulindac promotes the reaction [CDKN1A protein results in decreased activity of CDK2 protein]
Sulindac results in increased expression of CDKN1A mRNA; Sulindac results in increased expression of CDKN1A protein
[Azoxymethane co-treated with Sulindac] results in increased expression of CDKN1A protein
CDKN1A protein results in increased susceptibility to Sulindac
Sulindac results in increased activity of CDKN1A protein
Sulindac results in decreased activity of CDKN1A protein
CTD PMID:11507085 PMID:12628509 PMID:14566837 PMID:15190207 PMID:15688007 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP Sulindac inhibits the reaction [Azoxymethane results in decreased expression of CDKN1B protein] CTD PMID:12189186 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP Sulindac inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A mRNA] CTD PMID:12189186 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cfl2 cofilin 2 decreases expression EXP Sulindac results in decreased expression of CFL2 mRNA CTD PMID:24136188 NCBI chr 6:72,355,664...72,359,709
Ensembl chr 6:72,355,664...72,359,674
JBrowse link
G Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 decreases expression EXP Sulindac results in decreased expression of CHCHD3 mRNA CTD PMID:24136188 NCBI chr 4:61,360,352...61,616,850
Ensembl chr 4:61,360,353...61,616,847
JBrowse link
G Chchd5 coiled-coil-helix-coiled-coil-helix domain containing 5 increases expression EXP Sulindac results in increased expression of CHCHD5 mRNA CTD PMID:24136188 NCBI chr 3:116,361,845...116,372,238
Ensembl chr 3:116,361,885...116,367,169
JBrowse link
G Chd8 chromodomain helicase DNA binding protein 8 decreases expression EXP Sulindac results in decreased expression of CHD8 mRNA CTD PMID:24136188 NCBI chr15:24,905,789...24,965,461
Ensembl chr15:24,905,789...24,951,285
JBrowse link
G Chmp2a charged multivesicular body protein 2A decreases expression EXP Sulindac results in decreased expression of CHMP2A mRNA CTD PMID:24136188 NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452
JBrowse link
G Chrac1 chromatin accessibility complex subunit 1 increases expression EXP Sulindac results in increased expression of CHRAC1 mRNA CTD PMID:24136188 NCBI chr 7:105,013,047...105,016,435
Ensembl chr 7:105,013,015...105,017,136
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Sulindac inhibits the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:15489888 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit increases expression EXP Sulindac results in increased expression of CLPP mRNA CTD PMID:24136188 NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,830,311...1,837,693
JBrowse link
G Clu clusterin affects expression ISO Sulindac affects the expression of CLU protein CTD PMID:12388792 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 increases expression EXP Sulindac results in increased expression of CMTM6 mRNA CTD PMID:24136188 NCBI chr 8:114,422,681...114,441,034
Ensembl chr 8:114,422,921...114,441,033
JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 decreases expression EXP Sulindac results in decreased expression of CNGB1 mRNA CTD PMID:24136188 NCBI chr19:9,726,595...9,791,111
Ensembl chr19:9,726,595...9,791,173
JBrowse link
G Cnnm4 cyclin and CBS domain divalent metal cation transport mediator 4 increases expression ISO Sulindac results in increased expression of CNNM4 mRNA CTD PMID:11906190 NCBI chr 9:38,711,726...38,750,942
Ensembl chr 9:38,711,710...38,750,942
JBrowse link
G Cnot6 CCR4-NOT transcription complex, subunit 6 decreases expression EXP Sulindac results in decreased expression of CNOT6 mRNA CTD PMID:24136188 NCBI chr10:33,978,785...34,031,025
Ensembl chr10:33,980,831...34,031,025
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO Sulindac results in increased expression of COL1A2 mRNA CTD PMID:18499699 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col5a2 collagen type V alpha 2 chain increases expression ISO Sulindac results in increased expression of COL5A2 mRNA CTD PMID:18499699 NCBI chr 9:47,448,736...47,598,396
Ensembl chr 9:47,448,736...47,598,154
JBrowse link
G Col6a2 collagen type VI alpha 2 chain increases expression ISO Sulindac results in increased expression of COL6A2 mRNA CTD PMID:18499699 NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564
JBrowse link
G Col6a3 collagen type VI alpha 3 chain increases expression ISO Sulindac results in increased expression of COL6A3 mRNA CTD PMID:18499699 NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471
JBrowse link
G Commd3 COMM domain containing 3 increases expression EXP Sulindac results in increased expression of COMMD3 mRNA CTD PMID:24136188 NCBI chr17:81,327,451...81,331,183
Ensembl chr17:81,327,405...81,331,177
JBrowse link
G Commd5 COMM domain containing 5 increases expression EXP Sulindac results in increased expression of COMMD5 mRNA CTD PMID:24136188 NCBI chr 7:108,621,766...108,623,616
Ensembl chr 7:108,598,673...108,624,764
JBrowse link
G Cops7a COP9 signalosome subunit 7A increases expression EXP Sulindac results in increased expression of COPS7A mRNA CTD PMID:24136188 NCBI chr 4:157,766,626...157,792,632
Ensembl chr 4:157,766,588...157,773,948
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 increases expression EXP Sulindac results in increased expression of COX15 mRNA CTD PMID:24136188 NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261
JBrowse link
G Cpne1 copine 1 decreases expression ISO Sulindac results in decreased expression of CPNE1 mRNA CTD PMID:11906190 NCBI chr 3:144,587,548...144,629,603
Ensembl chr 3:144,588,995...144,598,636
JBrowse link
G Cpsf3 cleavage and polyadenylation specific factor 3 increases expression EXP Sulindac results in increased expression of CPSF3 mRNA CTD PMID:24136188 NCBI chr 6:40,836,121...40,864,129
Ensembl chr 6:40,836,097...40,864,128
JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 increases expression EXP Sulindac results in increased expression of CREB3L3 mRNA CTD PMID:24136188 NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048
JBrowse link
G Crebzf CREB/ATF bZIP transcription factor increases expression EXP Sulindac results in increased expression of CREBZF mRNA CTD PMID:24136188 NCBI chr 1:144,416,864...144,423,540
Ensembl chr 1:144,417,446...144,428,553
JBrowse link
G Cry2 cryptochrome circadian regulator 2 decreases expression EXP Sulindac results in decreased expression of CRY2 mRNA CTD PMID:24136188 NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965
JBrowse link
G Csf1 colony stimulating factor 1 decreases expression EXP Sulindac results in decreased expression of CSF1 mRNA CTD PMID:24136188 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csk C-terminal Src kinase multiple interactions ISO
EXP
CSK protein affects the reaction [Sulindac results in increased expression of CDKN1A protein]
[[Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein] which results in increased phosphorylation of and results in decreased activity of SRC protein; [Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein
CTD PMID:18644992 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292
JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases expression
increases expression
ISO
EXP
Sulindac results in decreased expression of CSNK2A1 mRNA
Sulindac results in increased expression of CSNK2A1 mRNA
CTD PMID:11906190 PMID:24136188 NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 increases expression ISO Sulindac results in increased expression of CSNK2A2 mRNA CTD PMID:11906190 NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO
EXP
CTNNB1 protein affects the reaction [Sulindac results in decreased expression of CCND1 protein]; CTNNB1 protein affects the reaction [Sulindac results in decreased expression of CDK4 protein]; CTNNB1 protein affects the reaction [Sulindac results in decreased expression of MYC protein]; Sulindac results in decreased activity of [LEF1 protein binds to CTNNB1 protein]
epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]]; Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]
Sulindac results in decreased expression of CTNNB1 protein
[Sulindac co-treated with Plant Extracts] results in decreased expression of CTNNB1 protein
CTD PMID:10223192 PMID:11751639 PMID:12351151 PMID:18291362 PMID:29999212 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsb cathepsin B multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of CTSB mRNA] CTD PMID:15190207 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions ISO Sulindac inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA] CTD PMID:17010317 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
increases activity
ISO
EXP
Sulindac results in increased expression of CYP1A1 mRNA
Sulindac results in increased activity of CYP1A1 protein
CTD PMID:16531450 PMID:17985343 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression
ISO
EXP
Sulindac results in increased expression of CYP1A2 mRNA
Sulindac results in decreased expression of CYP1A2 mRNA
CTD PMID:16531450 PMID:17985343 PMID:24136188 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
increases activity
ISO
EXP
Sulindac results in increased expression of CYP1B1 mRNA
Sulindac results in increased activity of CYP1B1 protein
CTD PMID:16531450 PMID:17985343 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP2D4 mRNA CTD PMID:20371263 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP2J4 mRNA CTD PMID:20371263 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP4B1 mRNA CTD PMID:20371263 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP8B1 mRNA CTD PMID:20371263 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dcn decorin decreases expression ISO Sulindac results in decreased expression of DCN mRNA CTD PMID:11507085 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Dctn5 dynactin subunit 5 decreases expression EXP Sulindac results in decreased expression of DCTN5 mRNA CTD PMID:24136188 NCBI chr 1:176,689,176...176,705,907
Ensembl chr 1:176,689,156...176,705,906
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [Sulindac co-treated with epigallocatechin gallate] results in increased expression of DDIT3 mRNA
Sulindac results in increased expression of DDIT3 mRNA
CTD PMID:12628509 PMID:24136188 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddx1 DEAD-box helicase 1 decreases expression EXP Sulindac results in decreased expression of DDX1 mRNA CTD PMID:24136188 NCBI chr 6:35,996,469...36,027,340
Ensembl chr 6:35,996,469...36,027,365
JBrowse link
G Degs1 delta(4)-desaturase, sphingolipid 1 increases expression EXP Sulindac results in increased expression of DEGS1 mRNA CTD PMID:24136188 NCBI chr13:93,946,154...93,953,677
Ensembl chr13:93,946,157...93,953,664
JBrowse link
G Dffb DNA fragmentation factor subunit beta affects localization ISO Sulindac affects the localization of DFFB protein CTD PMID:15946692 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Sulindac results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
JBrowse link
G Dhx36 DEAH-box helicase 36 increases expression EXP Sulindac results in increased expression of DHX36 mRNA CTD PMID:24136188 NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572
JBrowse link
G Dip2c disco-interacting protein 2 homolog C increases expression EXP Sulindac results in increased expression of DIP2C mRNA CTD PMID:24136188 NCBI chr17:60,647,346...61,032,467
Ensembl chr17:60,649,065...61,032,305
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 increases expression EXP Sulindac results in increased expression of DLG1 mRNA CTD PMID:24136188 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 increases expression EXP Sulindac results in increased expression of DNAJC10 mRNA CTD PMID:24136188 NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719
JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 increases expression EXP Sulindac results in increased expression of DNAJC15 mRNA CTD PMID:24136188 NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675
JBrowse link
G Dpys dihydropyrimidinase increases expression ISO Sulindac results in increased expression of DPYS mRNA CTD PMID:11906190 NCBI chr 7:70,822,648...70,929,255
Ensembl chr 7:70,835,789...70,929,231
JBrowse link
G Dynll1 dynein light chain LC8-type 1 decreases expression EXP Sulindac results in decreased expression of DYNLL1 mRNA CTD PMID:24136188 NCBI chr12:41,312,367...41,314,742
Ensembl chr12:41,312,367...41,314,741
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Sulindac results in decreased expression of E2F1 protein CTD PMID:16488075 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Eci2 enoyl-CoA delta isomerase 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ECI2 mRNA CTD PMID:20371263 NCBI chr17:29,850,884...29,886,781
Ensembl chr17:29,870,391...29,886,781
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of BAD protein]; Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:12566304 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 decreases expression ISO Sulindac results in decreased expression of EHMT2 mRNA CTD PMID:11906190 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO Sulindac results in increased expression of EIF2AK3 mRNA CTD PMID:32535746 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif5b eukaryotic translation initiation factor 5B increases expression EXP Sulindac results in increased expression of EIF5B mRNA CTD PMID:24136188 NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482
JBrowse link
G Elapor2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 increases expression ISO Sulindac results in increased expression of ELAPOR2 mRNA CTD PMID:11906190 NCBI chr 4:24,613,163...24,805,729
Ensembl chr 4:24,613,163...24,805,729
JBrowse link
G Eloc elongin C increases expression EXP Sulindac results in increased expression of ELOC mRNA CTD PMID:24136188 NCBI chr 5:2,661,527...2,677,893
Ensembl chr 5:2,661,724...2,677,890
JBrowse link
G Endog endonuclease G affects localization ISO Sulindac affects the localization of ENDOG protein CTD PMID:15946692 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease decreases expression ISO Sulindac results in decreased expression of ERCC5 mRNA CTD PMID:11906190 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Sulindac results in increased expression of ERN1 mRNA CTD PMID:32535746 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 decreases expression EXP Sulindac results in decreased expression of ERRFI1 mRNA CTD PMID:24136188 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282
JBrowse link
G Ess2 ess-2 splicing factor homolog increases expression ISO Sulindac results in increased expression of ESS2 mRNA CTD PMID:11906190 NCBI chr11:83,075,893...83,085,849
Ensembl chr11:83,075,925...83,084,846
JBrowse link
G Etfdh electron transfer flavoprotein dehydrogenase decreases expression EXP Sulindac results in decreased expression of ETFDH mRNA CTD PMID:24136188 NCBI chr 2:164,740,547...164,762,754
Ensembl chr 2:164,729,749...164,762,745
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor increases expression ISO Sulindac results in increased expression of ETS1 mRNA CTD PMID:11906190 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
JBrowse link
G Exoc3 exocyst complex component 3 decreases expression EXP Sulindac results in decreased expression of EXOC3 mRNA CTD PMID:24136188 NCBI chr 1:29,091,298...29,122,056
Ensembl chr 1:29,091,294...29,122,045
JBrowse link
G Exoc7 exocyst complex component 7 increases expression EXP Sulindac results in increased expression of EXOC7 mRNA CTD PMID:24136188 NCBI chr10:101,521,640...101,563,123
Ensembl chr10:101,520,927...101,540,561
JBrowse link
G Exosc5 exosome component 5 decreases expression EXP Sulindac results in decreased expression of EXOSC5 mRNA CTD PMID:24136188 NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265
JBrowse link
G Exosc7 exosome component 7 decreases expression EXP Sulindac results in decreased expression of EXOSC7 mRNA CTD PMID:24136188 NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270
JBrowse link
G Fam219b family with sequence similarity 219, member B decreases expression EXP Sulindac results in decreased expression of FAM219B mRNA CTD PMID:24136188 NCBI chr 8:57,941,251...57,946,916
Ensembl chr 8:57,941,294...57,946,906
JBrowse link
G Fam241b family with sequence similarity 241 member B increases expression EXP Sulindac results in increased expression of FAM241B mRNA CTD PMID:24136188 NCBI chr20:30,052,315...30,055,247
Ensembl chr20:30,052,324...30,055,084
JBrowse link
G Fasn fatty acid synthase increases expression ISO Sulindac results in increased expression of FASN mRNA CTD PMID:32535746 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbxl4 F-box and leucine-rich repeat protein 4 increases expression EXP Sulindac results in increased expression of FBXL4 mRNA CTD PMID:24136188 NCBI chr 5:35,955,801...36,029,446
Ensembl chr 5:35,955,812...36,029,443
JBrowse link
G Fbxo42 F-box protein 42 increases expression ISO Sulindac results in increased expression of FBXO42 mRNA CTD PMID:11906190 NCBI chr 5:153,451,153...153,509,569
Ensembl chr 5:153,451,153...153,506,342
JBrowse link
G Fbxo6 F-box protein 6 decreases expression EXP Sulindac results in decreased expression of FBXO6 mRNA CTD PMID:24136188 NCBI chr 5:158,576,729...158,582,520
Ensembl chr 5:158,576,759...158,582,525
JBrowse link
G Fhl2 four and a half LIM domains 2 increases expression ISO Sulindac results in increased expression of FHL2 mRNA CTD PMID:11906190 NCBI chr 9:45,388,979...45,462,530
Ensembl chr 9:45,388,981...45,431,192
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A decreases expression EXP Sulindac results in decreased expression of FKBP1A mRNA CTD PMID:24136188 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
JBrowse link
G Fli1 Fli-1 proto-oncogene, ETS transcription factor decreases expression EXP Sulindac results in decreased expression of FLI1 mRNA CTD PMID:24136188 NCBI chr 8:30,831,422...30,950,468
Ensembl chr 8:30,832,753...30,950,433
JBrowse link
G Flnb filamin B increases expression EXP Sulindac results in increased expression of FLNB mRNA CTD PMID:24136188 NCBI chr15:16,961,999...17,095,059
Ensembl chr15:16,962,003...17,095,006
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing
increases metabolic processing
multiple interactions
ISO FMO3 gene polymorphism affects the metabolism of Sulindac
FMO3 protein results in increased metabolism of Sulindac
FMO3 gene polymorphism results in decreased metabolism of and results in increased susceptibility to Sulindac
CTD PMID:15623613 PMID:17050781 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Sulindac results in decreased expression of FOS protein CTD PMID:15020200 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO Sulindac results in increased expression of FTH1 mRNA CTD PMID:11093808 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Ftl1 ferritin light chain 1 decreases expression EXP Sulindac results in decreased expression of FTL1 mRNA CTD PMID:24136188 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Fxn frataxin increases expression EXP Sulindac results in increased expression of FXN mRNA CTD PMID:24136188 NCBI chr 1:221,874,007...221,897,841
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Sulindac results in increased expression of GADD45A mRNA CTD PMID:11906190 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gal galanin and GMAP prepropeptide affects expression ISO Sulindac affects the expression of GAL protein CTD PMID:12388792 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Galk1 galactokinase 1 increases expression EXP Sulindac results in increased expression of GALK1 mRNA CTD PMID:24136188 NCBI chr10:101,243,146...101,247,323
Ensembl chr10:101,235,994...101,247,337
JBrowse link
G Gap43 growth associated protein 43 affects expression ISO Sulindac affects the expression of GAP43 protein CTD PMID:12388792 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gatad1 GATA zinc finger domain containing 1 increases expression EXP Sulindac results in increased expression of GATAD1 mRNA CTD PMID:24136188 NCBI chr 4:30,507,530...30,519,109
Ensembl chr 4:30,507,538...30,519,107
JBrowse link
G Gatad2a GATA zinc finger domain containing 2A increases expression EXP Sulindac results in increased expression of GATAD2A mRNA CTD PMID:24136188 NCBI chr16:19,429,578...19,520,320
Ensembl chr16:19,429,578...19,519,587
JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A decreases expression ISO Sulindac results in decreased expression of GATD3 mRNA CTD PMID:11906190 NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885
JBrowse link
G Gba glucosylceramidase beta multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GBA mRNA] CTD PMID:15190207 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Gcdh glutaryl-CoA dehydrogenase multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GCDH mRNA CTD PMID:20371263 NCBI chr19:23,263,215...23,269,689
Ensembl chr19:23,263,264...23,269,681
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
affects expression
ISO Acetylcysteine inhibits the reaction [Sulindac results in increased expression of GCLC protein]
Sulindac affects the expression of GCLC mRNA
CTD PMID:11820781 PMID:15946948 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gcnt1 glucosaminyl (N-acetyl) transferase 1 increases expression ISO Sulindac results in increased expression of GCNT1 mRNA CTD PMID:11093808 NCBI chr 1:214,718,344...214,755,735
Ensembl chr 1:214,718,293...214,758,776
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Sulindac results in increased expression of GDF15 mRNA; Sulindac results in increased expression of GDF15 protein CTD PMID:11906190 PMID:11984525 PMID:15180942 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Ghitm growth hormone inducible transmembrane protein increases expression EXP Sulindac results in increased expression of GHITM mRNA CTD PMID:24136188 NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879
JBrowse link
G Ghr growth hormone receptor multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GHR mRNA CTD PMID:20371263 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
JBrowse link
G Glo1 glyoxalase 1 decreases activity ISO Sulindac results in decreased activity of GLO1 protein CTD PMID:17243824 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Gnas GNAS complex locus increases expression EXP Sulindac results in increased expression of GNAS mRNA CTD PMID:24136188 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gnl3l G protein nucleolar 3 like decreases expression EXP Sulindac results in decreased expression of GNL3L mRNA CTD PMID:24136188 NCBI chr  X:19,961,277...19,994,454
Ensembl chr  X:19,958,603...19,994,508
JBrowse link
G Gnmt glycine N-methyltransferase decreases expression EXP Sulindac results in decreased expression of GNMT mRNA CTD PMID:24136188 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GPX3 mRNA CTD PMID:20371263 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Grb10 growth factor receptor bound protein 10 increases expression ISO Sulindac results in increased expression of GRB10 mRNA CTD PMID:11906190 NCBI chr14:86,495,054...86,602,815
Ensembl chr14:86,495,054...86,602,806
JBrowse link
G Grb2 growth factor receptor bound protein 2 increases expression EXP Sulindac results in increased expression of GRB2 mRNA CTD PMID:24136188 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 affects expression EXP Sulindac affects the expression of GRIN1 protein CTD PMID:15123337 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B affects expression EXP Sulindac affects the expression of GRIN2B protein CTD PMID:15123337 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 decreases expression EXP Sulindac results in decreased expression of GRK6 mRNA CTD PMID:24136188 NCBI chr17:9,177,018...9,192,644
Ensembl chr17:9,177,019...9,192,644
JBrowse link
G Grn granulin precursor multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GRN mRNA] CTD PMID:15190207 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO Sulindac results in decreased phosphorylation of GSK3B protein CTD PMID:11593435 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GSTM2 mRNA CTD PMID:20371263 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP Sulindac results in increased expression of GSTT1 protein CTD PMID:9729437 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gtf2b general transcription factor IIB increases expression
decreases expression
ISO
EXP
Sulindac results in increased expression of GTF2B mRNA
Sulindac results in decreased expression of GTF2B mRNA
CTD PMID:11906190 PMID:24136188 NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Arsenic Trioxide co-treated with Sulindac] results in increased phosphorylation of H2AX protein CTD PMID:18636201 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G H2az1 H2A.Z variant histone 1 increases expression EXP Sulindac results in increased expression of H2AZ1 mRNA CTD PMID:24136188 NCBI chr 2:226,355,769...226,357,878
Ensembl chr 2:226,355,708...226,358,485
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression EXP Sulindac results in decreased expression of HADHB mRNA CTD PMID:24136188 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
JBrowse link
G Helz2 helicase with zinc finger 2 decreases expression EXP Sulindac results in decreased expression of HELZ2 mRNA CTD PMID:24136188 NCBI chr 3:168,338,813...168,353,219
Ensembl chr 3:168,338,813...168,353,159
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Sulindac results in increased expression of HERPUD1 mRNA CTD PMID:11093808 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
ISO [AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]] which affects the susceptibility to Oxygen; AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]
Sulindac analog results in decreased expression of HIF1A mRNA; Sulindac analog results in decreased expression of HIF1A protein
CTD PMID:18924134 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A increases expression EXP Sulindac results in increased expression of HIGD1A mRNA CTD PMID:24136188 NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443
JBrowse link
G Hlcs holocarboxylase synthetase decreases expression ISO Sulindac results in decreased expression of HLCS mRNA CTD PMID:11906190 NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222
JBrowse link
G Hmgb3 high mobility group box 3 increases expression EXP Sulindac results in increased expression of HMGB3 mRNA CTD PMID:24136188 NCBI chr  X:149,296,309...149,301,294
Ensembl chr  X:149,296,375...149,301,292
JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO Sulindac results in decreased expression of HMMR mRNA CTD PMID:11906190 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]]; pyrazolanthrone inhibits the reaction [Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]]; SB 203580 inhibits the reaction [Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]]; Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]
Sulindac results in decreased expression of HMOX1 protein
CTD PMID:18636201 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of HNF4A mRNA CTD PMID:20371263 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of HSD17B4 mRNA CTD PMID:20371263 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Sulindac results in increased activity of HSF1 protein CTD PMID:10328874 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression EXP Sulindac results in increased expression of HSPA9 mRNA CTD PMID:24136188 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Sulindac results in decreased expression of ICAM1 protein CTD PMID:18059344 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression EXP Sulindac results in decreased expression of IFI27 mRNA CTD PMID:24136188 NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 decreases expression EXP Sulindac results in decreased expression of IFITM3 mRNA CTD PMID:24136188 NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 decreases expression EXP Sulindac results in decreased expression of IFNAR1 mRNA CTD PMID:24136188 NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979
JBrowse link
G Ifng interferon gamma multiple interactions ISO Sulindac inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA] CTD PMID:17010317 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Iftap intraflagellar transport associated protein increases expression EXP Sulindac results in increased expression of IFTAP mRNA CTD PMID:24136188 NCBI chr 3:87,812,068...87,906,517
Ensembl chr 3:87,817,408...87,906,547
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases activity ISO Sulindac results in decreased activity of IKBKB protein CTD PMID:19526344 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 increases expression EXP Sulindac results in increased expression of IL11RA1 mRNA CTD PMID:24136188 NCBI chr 5:56,931,824...56,941,408
Ensembl chr 5:56,935,516...56,941,408
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of IL1A mRNA CTD PMID:20371263 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
decreases expression
ISO
EXP
[Sulindac co-treated with epigallocatechin gallate] results in decreased expression of IL1B mRNA; Sulindac inhibits the reaction [IL1B protein results in increased abundance of Hyaluronic Acid]; Sulindac inhibits the reaction [IL1B protein results in increased expression of CCL5 mRNA]
Sulindac results in increased expression of IL1B
Sulindac results in decreased expression of IL1B protein
Sulindac results in decreased expression of IL1B mRNA
CTD PMID:10328874 PMID:11318944 PMID:12628509 PMID:15123337 PMID:16159934 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 multiple interactions
increases expression
ISO Sulindac promotes the reaction [IL24 protein results in increased phosphorylation of MAPK8 protein]
[Sulindac results in increased expression of IL24 protein] which results in increased expression of CASP3 protein; [Sulindac results in increased expression of IL24 protein] which results in increased expression of CASP9 protein; Sulindac results in increased expression of IL24 protein
CTD PMID:15713900 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of IL6 mRNA
Sulindac results in increased expression of IL6
CTD PMID:20371263 PMID:24136188 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ilk integrin-linked kinase decreases activity ISO Sulindac results in decreased activity of ILK protein CTD PMID:11593435 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
JBrowse link
G Inpp5e inositol polyphosphate-5-phosphatase E increases expression ISO Sulindac results in increased expression of INPP5E mRNA CTD PMID:11906190 NCBI chr 3:9,216,776...9,229,539
Ensembl chr 3:9,216,776...9,229,450
JBrowse link
G Ipmk inositol polyphosphate multikinase decreases expression EXP Sulindac results in decreased expression of IPMK mRNA CTD PMID:24136188 NCBI chr20:17,216,988...17,251,675
Ensembl chr20:17,218,037...17,251,705
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of IRAK2 mRNA CTD PMID:20371263 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression EXP Sulindac results in decreased expression of IRF7 mRNA CTD PMID:24136188 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Isca1 iron-sulfur cluster assembly 1 decreases expression EXP Sulindac results in decreased expression of ISCA1 mRNA CTD PMID:24136188 NCBI chr17:4,905,291...4,917,955
Ensembl chr17:4,905,287...4,917,955
JBrowse link
G Itga2 integrin subunit alpha 2 increases expression ISO Sulindac results in increased expression of ITGA2 mRNA CTD PMID:11906190 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of ITGB3 mRNA] CTD PMID:15190207 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Itgb4 integrin subunit beta 4 multiple interactions ISO [Sulindac co-treated with epigallocatechin gallate] results in decreased expression of ITGB4 mRNA CTD PMID:12628509 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
JBrowse link
G Jkamp JNK1/MAPK8-associated membrane protein decreases expression EXP Sulindac results in decreased expression of JKAMP mRNA CTD PMID:24136188 NCBI chr 6:90,648,043...90,661,985
Ensembl chr 6:90,648,160...90,662,501
JBrowse link
G Josd1 Josephin domain containing 1 decreases expression EXP Sulindac results in decreased expression of JOSD1 mRNA CTD PMID:24136188 NCBI chr 7:111,230,318...111,244,241
Ensembl chr 7:111,230,318...111,244,652
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO Sulindac results in decreased expression of JUN protein
[Sulindac co-treated with Plant Extracts] results in decreased expression of JUN protein
CTD PMID:12351151 PMID:12584176 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO Sulindac results in increased expression of JUND mRNA CTD PMID:11906190 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Kcnh3 potassium voltage-gated channel subfamily H member 3 decreases expression EXP Sulindac results in decreased expression of KCNH3 mRNA CTD PMID:24136188 NCBI chr 7:130,365,593...130,383,859
Ensembl chr 7:130,366,011...130,383,855
JBrowse link
G Kctd5 potassium channel tetramerization domain containing 5 increases expression EXP Sulindac results in increased expression of KCTD5 mRNA CTD PMID:24136188 NCBI chr10:13,079,216...13,105,197
Ensembl chr10:13,079,214...13,105,209
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression EXP Sulindac results in decreased expression of KEAP1 mRNA CTD PMID:24136188 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Khsrp KH-type splicing regulatory protein increases expression EXP Sulindac results in increased expression of KHSRP mRNA CTD PMID:24136188 NCBI chr 9:1,862,555...1,872,301
Ensembl chr 9:1,862,899...1,872,451
JBrowse link
G Kif14 kinesin family member 14 increases expression ISO Sulindac results in increased expression of KIF14 mRNA CTD PMID:11906190 NCBI chr13:47,926,975...47,990,598
Ensembl chr13:47,927,044...47,989,164
JBrowse link
G Klf5 Kruppel-like factor 5 increases expression ISO Sulindac results in increased expression of KLF5 mRNA CTD PMID:11906190 NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445
JBrowse link
G Kras KRAS proto-oncogene, GTPase affects response to substance ISO KRAS protein affects the susceptibility to Sulindac CTD PMID:11751493 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lad1 ladinin 1 increases expression ISO Sulindac results in increased expression of LAD1 mRNA CTD PMID:11507085 NCBI chr13:47,249,605...47,263,967
Ensembl chr13:47,249,605...47,263,967
JBrowse link
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 decreases expression EXP Sulindac results in decreased expression of LAMTOR4 mRNA CTD PMID:24136188 NCBI chr12:17,258,656...17,262,478
Ensembl chr12:17,258,623...17,262,480
JBrowse link
G Larp1b La ribonucleoprotein 1B decreases expression EXP Sulindac results in decreased expression of LARP1B mRNA CTD PMID:24136188 NCBI chr 2:123,936,074...123,969,254
Ensembl chr 2:123,935,983...123,968,896
JBrowse link
G Larp4 La ribonucleoprotein 4 increases expression ISO Sulindac results in increased expression of LARP4 mRNA CTD PMID:11906190 NCBI chr 7:131,104,470...131,152,692 JBrowse link
G Lbp lipopolysaccharide binding protein multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of LBP mRNA CTD PMID:20371263 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Ldb1 LIM domain binding 1 increases expression ISO Sulindac results in increased expression of LDB1 mRNA CTD PMID:11906190 NCBI chr 1:244,864,168...244,890,007
Ensembl chr 1:244,877,173...244,890,013
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO Sulindac results in decreased activity of [LEF1 protein binds to CTNNB1 protein] CTD PMID:11751639 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase increases expression ISO Sulindac results in increased expression of LFNG mRNA CTD PMID:11906190 NCBI chr12:14,030,551...14,038,996
Ensembl chr12:14,018,333...14,039,008
JBrowse link
G Lgals3 galectin 3 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3 mRNA] CTD PMID:15190207 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lgals3bp galectin 3 binding protein multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3BP mRNA] CTD PMID:15190207 NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256
JBrowse link
G Lipe lipase E, hormone sensitive type decreases expression EXP Sulindac results in decreased expression of LIPE mRNA CTD PMID:24136188 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor increases expression EXP Sulindac results in increased expression of LITAF mRNA CTD PMID:24136188 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763
JBrowse link
G Lmf2 lipase maturation factor 2 decreases expression EXP Sulindac results in decreased expression of LMF2 mRNA CTD PMID:24136188 NCBI chr 7:120,418,343...120,422,825
Ensembl chr 7:120,418,345...120,422,823
JBrowse link
G LOC100912290 histone H4-like increases expression ISO Sulindac results in increased expression of H4C15 mRNA CTD PMID:11906190
G Lonp1 lon peptidase 1, mitochondrial decreases expression EXP Sulindac results in decreased expression of LONP1 mRNA CTD PMID:24136188 NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771
JBrowse link
G Lox lysyl oxidase decreases expression ISO Sulindac analog results in decreased expression of LOX mRNA CTD PMID:18924134 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing decreases expression EXP Sulindac results in decreased expression of LRPPRC mRNA CTD PMID:24136188 NCBI chr 6:9,859,867...9,942,294
Ensembl chr 6:9,859,867...9,942,293
JBrowse link
G Lsm10 LSM10, U7 small nuclear RNA associated increases expression EXP Sulindac results in increased expression of LSM10 mRNA CTD PMID:24136188 NCBI chr 5:138,365,983...138,375,856
Ensembl chr 5:138,373,119...138,377,505
JBrowse link
G Lsm12 LSM12 homolog increases expression EXP Sulindac results in increased expression of LSM12 mRNA CTD PMID:24136188 NCBI chr10:87,118,334...87,140,395
Ensembl chr10:87,118,416...87,140,396
JBrowse link
G Lsm6 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated increases expression EXP Sulindac results in increased expression of LSM6 mRNA CTD PMID:24136188 NCBI chr19:29,098,254...29,112,858
Ensembl chr19:29,098,214...29,118,682
JBrowse link
G Macroh2a1 macroH2A.1 histone decreases expression EXP Sulindac results in decreased expression of MACROH2A1 mRNA CTD PMID:24136188 NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072
JBrowse link
G Maoa monoamine oxidase A decreases expression EXP Sulindac results in decreased expression of MAOA mRNA CTD PMID:24136188 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Maob monoamine oxidase B multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MAOB mRNA CTD PMID:20371263 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MAP3K8 mRNA CTD PMID:20371263 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
JBrowse link
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 increases expression ISO Sulindac results in increased expression of MAP4K3 mRNA CTD PMID:11906190 NCBI chr 6:14,276,623...14,446,321
Ensembl chr 6:14,277,121...14,446,334
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of MAPK1 protein; Arsenic Trioxide promotes the reaction [Sulindac results in increased phosphorylation of MAPK1 protein]; Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Sulindac promotes the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK1 protein]
[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MAPK1 mRNA
CTD PMID:12566304 PMID:18281123 PMID:18636201 PMID:20371263 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of MAPK3 protein; Arsenic Trioxide promotes the reaction [Sulindac results in increased phosphorylation of MAPK3 protein]; Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Sulindac promotes the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein] CTD PMID:12566304 PMID:18281123 PMID:18636201 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
increases expression
ISO CDKN1A protein promotes the reaction [Sulindac results in increased expression of and results in increased phosphorylation of MAPK8 protein]; MAPK8 affects the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein]; Sulindac promotes the reaction [IL24 protein results in increased phosphorylation of MAPK8 protein]; Sulindac results in increased expression of and results in increased phosphorylation of MAPK8 protein; Sulindac results in increased phosphorylation of and results in increased activity of MAPK8 protein
Sulindac results in increased phosphorylation of MAPK8 protein
Sulindac results in increased expression of MAPK8 mRNA
CTD PMID:15713900 PMID:17292881 PMID:18281123 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mark3 microtubule affinity regulating kinase 3 decreases expression EXP Sulindac results in decreased expression of MARK3 mRNA CTD PMID:24136188 NCBI chr 6:130,626,612...130,716,245
Ensembl chr 6:130,627,482...130,716,647
JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 decreases expression EXP Sulindac results in decreased expression of MBD2 mRNA CTD PMID:24136188 NCBI chr18:64,174,002...64,240,795
Ensembl chr18:64,174,002...64,240,794
JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 decreases expression EXP Sulindac results in decreased expression of MBD3 mRNA CTD PMID:24136188 NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165
JBrowse link
G Me1 malic enzyme 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ME1 mRNA CTD PMID:20371263 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Med10 mediator complex subunit 10 increases expression EXP Sulindac results in increased expression of MED10 mRNA CTD PMID:24136188 NCBI chr 1:33,470,064...33,481,698
Ensembl chr 1:33,470,066...33,475,767
JBrowse link
G Med15 mediator complex subunit 15 increases expression ISO Sulindac results in increased expression of MED15 mRNA CTD PMID:11906190 NCBI chr11:83,280,722...83,356,006
Ensembl chr11:83,280,762...83,355,362
JBrowse link
G Mesd mesoderm development LRP chaperone decreases expression EXP Sulindac results in decreased expression of MESD mRNA CTD PMID:24136188 NCBI chr 1:137,866,707...137,879,999
Ensembl chr 1:137,874,242...137,879,999
JBrowse link
G Mettl23 methyltransferase like 23 increases expression EXP Sulindac results in increased expression of METTL23 mRNA CTD PMID:24136188 NCBI chr10:102,047,090...102,053,379
Ensembl chr10:102,047,314...102,051,977
JBrowse link
G Mfap3 microfibril associated protein 3 decreases expression EXP Sulindac results in decreased expression of MFAP3 mRNA CTD PMID:24136188 NCBI chr10:41,696,788...41,711,490
Ensembl chr10:41,696,771...41,710,406
JBrowse link
G Mff mitochondrial fission factor decreases expression EXP Sulindac results in decreased expression of MFF mRNA CTD PMID:24136188 NCBI chr 9:84,007,798...84,036,039
Ensembl chr 9:84,007,798...84,036,039
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MGST2 mRNA CTD PMID:20371263 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MGST3 mRNA CTD PMID:20371263 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
JBrowse link
G Miip migration and invasion inhibitory protein increases expression ISO Sulindac results in increased expression of MIIP mRNA CTD PMID:11906190 NCBI chr 5:158,292,510...158,299,531
Ensembl chr 5:158,292,511...158,299,694
JBrowse link
G Mllt6 MLLT6, PHD finger containing decreases expression EXP Sulindac results in decreased expression of MLLT6 mRNA CTD PMID:24136188 NCBI chr10:82,657,258...82,678,899
Ensembl chr10:82,656,872...82,676,073
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression EXP Sulindac results in decreased expression of MMP14 mRNA CTD PMID:24136188 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO Sulindac results in decreased expression of MMP7 mRNA; Sulindac results in decreased expression of MMP7 protein CTD PMID:18499699 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mogs mannosyl-oligosaccharide glucosidase decreases expression EXP Sulindac results in decreased expression of MOGS mRNA CTD PMID:24136188 NCBI chr 4:115,621,623...115,625,026
Ensembl chr 4:115,621,623...115,625,032
JBrowse link
G Mrpl1 mitochondrial ribosomal protein L1 decreases expression EXP Sulindac results in decreased expression of MRPL1 mRNA CTD PMID:24136188 NCBI chr14:13,300,522...13,359,654
Ensembl chr14:13,300,522...13,359,721
JBrowse link
G mrpl11 mitochondrial ribosomal protein L11 decreases expression EXP Sulindac results in decreased expression of MRPL11 mRNA CTD PMID:24136188 NCBI chr 1:202,264,419...202,267,288
Ensembl chr 1:202,264,471...202,267,756
JBrowse link
G Mrpl13 mitochondrial ribosomal protein L13 increases expression EXP Sulindac results in increased expression of MRPL13 mRNA CTD PMID:24136188 NCBI chr 7:86,951,541...86,973,147
Ensembl chr 7:86,951,541...86,973,577
JBrowse link
G Mrpl17 mitochondrial ribosomal protein L17 decreases expression EXP Sulindac results in decreased expression of MRPL17 mRNA CTD PMID:24136188 NCBI chr 1:160,162,181...160,163,870
Ensembl chr 1:160,158,807...160,163,815
JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 decreases expression EXP Sulindac results in decreased expression of MRPL20 mRNA CTD PMID:24136188 NCBI chr 5:166,408,962...166,413,492
Ensembl chr 5:166,408,962...166,413,492
JBrowse link
G Mrpl22 mitochondrial ribosomal protein L22 increases expression EXP Sulindac results in increased expression of MRPL22 mRNA CTD PMID:24136188 NCBI chr10:42,345,446...42,355,779
Ensembl chr10:42,342,776...42,355,779
JBrowse link
G Mrpl23 mitochondrial ribosomal protein L23 decreases expression EXP Sulindac results in decreased expression of MRPL23 mRNA CTD PMID:24136188 NCBI chr 1:197,687,452...197,695,222
Ensembl chr 1:197,687,347...197,695,222
JBrowse link
G Mrpl32 mitochondrial ribosomal protein L32 increases expression EXP Sulindac results in increased expression of MRPL32 mRNA CTD PMID:24136188 NCBI chr17:50,565,133...50,568,000
Ensembl chr17:50,565,055...50,568,010
JBrowse link
G Mrpl37 mitochondrial ribosomal protein L37 decreases expression EXP Sulindac results in decreased expression of MRPL37 mRNA CTD PMID:24136188 NCBI chr 5:121,827,892...121,846,187
Ensembl chr 5:121,829,111...121,846,176
JBrowse link
G Mrpl53 mitochondrial ribosomal protein L53 increases expression EXP Sulindac results in increased expression of MRPL53 mRNA CTD PMID:24136188 NCBI chr 4:115,615,329...115,616,219 JBrowse link
G Mrpl54 mitochondrial ribosomal protein L54 increases expression EXP Sulindac results in increased expression of MRPL54 mRNA CTD PMID:24136188 NCBI chr 7:8,452,801...8,455,321
Ensembl chr 7:8,452,716...8,455,321
JBrowse link
G Mrpl58 mitochondrial ribosomal protein L58 decreases expression EXP Sulindac results in decreased expression of MRPL58 mRNA CTD PMID:24136188 NCBI chr10:100,646,374...100,652,871
Ensembl chr10:100,646,216...100,652,871
JBrowse link
G Mrps14 mitochondrial ribosomal protein S14 decreases expression EXP Sulindac results in decreased expression of MRPS14 mRNA CTD PMID:24136188 NCBI chr13:72,429,168...72,434,915
Ensembl chr13:72,408,558...72,434,915
JBrowse link
G Mrps24 mitochondrial ribosomal protein S24 decreases expression EXP Sulindac results in decreased expression of MRPS24 mRNA CTD PMID:24136188 NCBI chr14:80,584,671...80,588,801
Ensembl chr14:80,584,673...80,588,871
JBrowse link
G Mrps31 mitochondrial ribosomal protein S31 decreases expression EXP Sulindac results in decreased expression of MRPS31 mRNA CTD PMID:24136188 NCBI chr16:69,601,349...69,621,609
Ensembl chr16:69,601,349...69,630,654
JBrowse link
G Mrps33 mitochondrial ribosomal protein S33 increases expression EXP Sulindac results in increased expression of MRPS33 mRNA CTD PMID:24136188 NCBI chr 4:68,596,729...68,605,547
Ensembl chr 4:68,596,729...68,605,428
JBrowse link
G Mrps7 mitochondrial ribosomal protein S7 decreases expression EXP Sulindac results in decreased expression of MRPS7 mRNA CTD PMID:24136188 NCBI chr10:100,843,691...100,846,838
Ensembl chr10:100,843,356...100,847,129
JBrowse link
G Mrps9 mitochondrial ribosomal protein S9 increases expression EXP Sulindac results in increased expression of MRPS9 mRNA CTD PMID:24136188 NCBI chr 9:45,113,554...45,172,375
Ensembl chr 9:45,113,554...45,172,375
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase increases expression ISO Sulindac results in increased expression of MTHFD2 mRNA CTD PMID:11906190 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
JBrowse link
G Mtpn myotrophin increases expression EXP Sulindac results in increased expression of MTPN mRNA CTD PMID:24136188 NCBI chr 4:64,159,273...64,186,686
Ensembl chr 4:64,157,641...64,186,724
JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO Sulindac results in increased expression of MTTP mRNA CTD PMID:32535746 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP Sulindac results in decreased expression of MUG1 mRNA CTD PMID:24136188 NCBI chr 4:155,076,270...155,130,051
Ensembl chr 4:155,076,312...155,130,051
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
increases expression
ISO
EXP
CTNNB1 protein affects the reaction [Sulindac results in decreased expression of MYC protein]
Sulindac inhibits the reaction [Azoxymethane results in increased expression of MYC mRNA]; Sulindac inhibits the reaction [Azoxymethane results in increased expression of MYC protein]
Sulindac results in increased expression of MYC mRNA
CTD PMID:12189186 PMID:12414619 PMID:17292881 PMID:18291362 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Mzf1 myeloid zinc finger 1 decreases expression EXP Sulindac results in decreased expression of MZF1 mRNA CTD PMID:24136188 NCBI chr 1:73,670,522...73,682,885
Ensembl chr 1:73,670,541...73,681,635
JBrowse link
G Naa35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit decreases expression EXP Sulindac results in decreased expression of NAA35 mRNA CTD PMID:24136188 NCBI chr17:5,034,360...5,086,456
Ensembl chr17:5,034,356...5,086,386
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase decreases expression EXP Sulindac results in decreased expression of NAMPT mRNA CTD PMID:24136188 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Nap1l1 nucleosome assembly protein 1-like 1 decreases expression ISO Sulindac results in decreased expression of NAP1L1 mRNA CTD PMID:11507085 NCBI chr 7:46,933,278...46,957,853
Ensembl chr 7:46,933,356...46,956,593
JBrowse link
G Nat1 N-acetyltransferase 1 decreases expression ISO Sulindac results in decreased expression of NAT1 mRNA CTD PMID:11828994 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression
decreases expression
ISO
EXP
Sulindac results in increased expression of NDRG1 mRNA
Sulindac results in decreased expression of NDRG1 mRNA
CTD PMID:16273229 PMID:24136188 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 decreases expression ISO Sulindac results in decreased expression of NDST2 mRNA CTD PMID:11906190 NCBI chr15:3,563,358...3,573,801
Ensembl chr15:3,563,358...3,573,801
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression EXP Sulindac results in increased expression of NDUFA5 mRNA CTD PMID:24136188 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 increases expression EXP Sulindac results in increased expression of NDUFV3 mRNA CTD PMID:24136188 NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074
JBrowse link
G Nek7 NIMA-related kinase 7 decreases expression EXP Sulindac results in decreased expression of NEK7 mRNA CTD PMID:24136188 NCBI chr13:50,022,212...50,149,374
Ensembl chr13:50,022,218...50,149,296
JBrowse link
G Neu1 neuraminidase 1 increases expression ISO Sulindac results in increased expression of NEU1 mRNA CTD PMID:11906190 NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745
JBrowse link
G Nfe2l1 nuclear factor, erythroid 2-like 1 increases expression ISO
EXP
Sulindac results in increased expression of NFE2L1 mRNA CTD PMID:11906190 PMID:24136188 NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318
JBrowse link
G Nfib nuclear factor I/B multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of NFIB mRNA CTD PMID:20371263 NCBI chr 5:96,759,208...96,973,092
Ensembl chr 5:96,764,653...96,975,479
JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated increases expression ISO Sulindac results in increased expression of NFIL3 mRNA CTD PMID:11906190 NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases activity
ISO Acetylcysteine inhibits the reaction [Sulindac analog results in decreased activity of NFKB1 protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Sulindac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15489888 PMID:18922898 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation
ISO
EXP
[[Sulindac co-treated with arsenic trioxide] results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein] which affects the localization of RELA protein; [Sulindac co-treated with arsenic trioxide] results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein; Sulindac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Sulindac results in increased degradation of and results in decreased expression of NFKBIA protein
[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of NFKBIA mRNA
Sulindac results in decreased phosphorylation of NFKBIA protein
CTD PMID:11591705 PMID:15489888 PMID:18059344 PMID:18575716 PMID:20371263 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold decreases expression EXP Sulindac results in decreased expression of NFU1 mRNA CTD PMID:24136188 NCBI chr 4:119,458,981...119,480,162
Ensembl chr 4:119,459,061...119,480,373
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 increases expression ISO Sulindac results in increased expression of NPC1 mRNA CTD PMID:11906190 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049
JBrowse link
G Nphp1 nephrocystin 1 increases expression EXP Sulindac results in increased expression of NPHP1 mRNA CTD PMID:24136188 NCBI chr 3:114,960,650...115,016,234
Ensembl chr 3:114,960,650...115,016,234
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
ISO Sulindac results in increased activity of NQO1 protein
Sulindac results in increased expression of NQO1 mRNA
CTD PMID:11093808 PMID:17985343 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor decreases expression EXP Sulindac results in decreased expression of NSMF mRNA CTD PMID:24136188 NCBI chr 3:7,861,846...7,870,615
Ensembl chr 3:7,861,872...7,870,614
JBrowse link
G Nudt16l1 nudix hydrolase 16 like 1 increases expression EXP Sulindac results in increased expression of NUDT16L1 mRNA CTD PMID:24136188 NCBI chr10:10,636,174...10,638,090
Ensembl chr10:10,636,174...10,688,370
JBrowse link
G Numb NUMB, endocytic adaptor protein increases expression EXP Sulindac results in increased expression of NUMB mRNA CTD PMID:24136188 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354
JBrowse link
G Nup37 nucleoporin 37 increases expression EXP Sulindac results in increased expression of NUP37 mRNA CTD PMID:24136188 NCBI chr 7:22,556,544...22,609,622
Ensembl chr 7:22,573,764...22,609,616
JBrowse link
G Nupr2 nuclear protein 2, transcriptional regulator increases expression EXP Sulindac results in increased expression of NUPR2 mRNA CTD PMID:24136188 NCBI chr12:26,800,123...26,803,228
Ensembl chr12:26,799,800...26,803,304
JBrowse link
G Orc4 origin recognition complex, subunit 4 decreases expression ISO Sulindac results in decreased expression of ORC4 mRNA CTD PMID:11906190 NCBI chr 3:33,290,844...33,334,022
Ensembl chr 3:33,294,355...33,333,824
JBrowse link
G Osbpl9 oxysterol binding protein-like 9 decreases expression EXP Sulindac results in decreased expression of OSBPL9 mRNA CTD PMID:24136188 NCBI chr 5:123,819,106...123,962,213
Ensembl chr 5:123,819,104...123,962,196
JBrowse link
G Ostf1 osteoclast stimulating factor 1 increases expression ISO Sulindac results in increased expression of OSTF1 mRNA CTD PMID:11906190 NCBI chr 1:216,002,037...216,049,250
Ensembl chr 1:216,002,044...216,049,221
JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 increases expression EXP Sulindac results in increased expression of OSTM1 mRNA CTD PMID:24136188 NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023
JBrowse link
G Otud1 OTU deubiquitinase 1 increases expression ISO Sulindac results in increased expression of OTUD1 mRNA CTD PMID:11906190 NCBI chr17:82,259,881...82,262,774
Ensembl chr17:82,259,840...82,262,995
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta decreases expression ISO Sulindac results in decreased expression of P4HB mRNA CTD PMID:32535746 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
JBrowse link
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 increases expression EXP Sulindac results in increased expression of PACSIN3 mRNA CTD PMID:24136188 NCBI chr 3:77,227,187...77,235,820
Ensembl chr 3:77,222,710...77,235,811
JBrowse link
G Pak6 p21 (RAC1) activated kinase 6 decreases expression EXP Sulindac results in decreased expression of PAK6 mRNA CTD PMID:24136188 NCBI chr 3:105,638,248...105,674,399
Ensembl chr 3:105,638,653...105,672,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity
ISO [Sulindac co-treated with arsenic trioxide] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased cleavage of PARP1 protein]; Sulindac promotes the reaction [Deferoxamine results in increased cleavage of PARP1 protein]
Sulindac results in increased activity of PARP1 protein
CTD PMID:15713900 PMID:18281123 PMID:21882223 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 decreases expression EXP Sulindac results in decreased expression of PARP14 mRNA CTD PMID:24136188 NCBI chr11:64,902,848...64,934,916
Ensembl chr11:64,902,785...64,934,916
JBrowse link
G Pbrm1 polybromo 1 decreases expression EXP Sulindac results in decreased expression of PBRM1 mRNA CTD PMID:24136188 NCBI chr16:6,213,507...6,312,895
Ensembl chr16:6,213,300...6,311,780
JBrowse link
G Pcbp1 poly(rC) binding protein 1 increases expression EXP Sulindac results in increased expression of PCBP1 mRNA CTD PMID:24136188 NCBI chr 4:118,972,698...118,974,722
Ensembl chr 4:118,972,661...118,976,500
JBrowse link
G Pcdh17 protocadherin 17 decreases expression ISO Sulindac results in decreased expression of PCDH17 mRNA CTD PMID:11906190 NCBI chr15:60,222,088...60,316,172
Ensembl chr15:60,222,004...60,313,999
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression ISO Sulindac results in increased expression of PCK2 mRNA CTD PMID:11906190 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions
ISO
EXP
Sulindac results in decreased expression of PCNA protein
epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]]; Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]
CTD PMID:15020200 PMID:29999212 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PDGFA mRNA CTD PMID:20371263 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Pdlim7 PDZ and LIM domain 7 increases expression ISO Sulindac results in increased expression of PDLIM7 mRNA CTD PMID:11906190 NCBI chr17:9,124,565...9,139,814
Ensembl chr17:9,124,649...9,139,811
JBrowse link
G Per1 period circadian regulator 1 decreases expression EXP Sulindac results in decreased expression of PER1 mRNA CTD PMID:24136188 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Pex2 peroxisomal biogenesis factor 2 increases expression EXP Sulindac results in increased expression of PEX2 mRNA CTD PMID:24136188 NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404
JBrowse link
G Pfdn6 prefoldin subunit 6 increases expression EXP Sulindac results in increased expression of PFDN6 mRNA CTD PMID:24136188 NCBI chr20:4,945,959...4,947,433
Ensembl chr20:4,945,959...4,947,433
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression EXP Sulindac results in decreased expression of PGAP2 mRNA CTD PMID:24136188 NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114
JBrowse link
G Pi4k2b phosphatidylinositol 4-kinase type 2 beta increases expression EXP Sulindac results in increased expression of PI4K2B mRNA CTD PMID:24136188 NCBI chr14:58,221,790...58,248,716
Ensembl chr14:58,220,437...58,248,673
JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha increases expression EXP Sulindac results in increased expression of PI4KA mRNA CTD PMID:24136188 NCBI chr11:83,609,136...83,726,876
Ensembl chr11:83,609,069...83,724,080
JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C increases expression EXP Sulindac results in increased expression of PIGC mRNA CTD PMID:24136188 NCBI chr13:74,343,619...74,346,148
Ensembl chr13:74,296,854...74,346,211
JBrowse link
G Pigy phosphatidylinositol glycan anchor biosynthesis, class Y increases expression EXP Sulindac results in increased expression of PIGY mRNA CTD PMID:24136188 NCBI chr 8:20,689,621...20,691,863
Ensembl chr 8:20,689,502...20,692,585
JBrowse link
G Pisd phosphatidylserine decarboxylase decreases expression EXP Sulindac results in decreased expression of PISD mRNA CTD PMID:24136188 NCBI chr14:77,941,927...77,991,021
Ensembl chr14:77,941,948...77,991,003
JBrowse link
G Pithd1 PITH domain containing 1 increases expression EXP Sulindac results in increased expression of PITHD1 mRNA CTD PMID:24136188 NCBI chr 5:148,205,995...148,216,511
Ensembl chr 5:148,205,998...148,217,080
JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting increases expression ISO Sulindac results in increased expression of PKD1 mRNA CTD PMID:11906190 NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions
decreases expression
ISO Sulindac inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein]
Sulindac results in decreased expression of PLA2G4A mRNA
CTD PMID:10706128 PMID:15816863 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [Sulindac co-treated with epigallocatechin gallate] results in decreased expression of PLAT mRNA CTD PMID:12628509 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PLCG1 mRNA CTD PMID:20371263 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Plec plectin increases expression EXP Sulindac results in increased expression of PLEC mRNA CTD PMID:24136188 NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467
JBrowse link
G Plekhb2 pleckstrin homology domain containing B2 decreases expression EXP Sulindac results in decreased expression of PLEKHB2 mRNA CTD PMID:24136188 NCBI chr 9:37,049,580...37,082,231
Ensembl chr 9:37,038,751...37,082,231
JBrowse link
G Plekhf1 pleckstrin homology and FYVE domain containing 1 increases expression ISO Sulindac results in increased expression of PLEKHF1 mRNA CTD PMID:11906190 NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820
JBrowse link
G Plxna3 plexin A3 increases expression ISO Sulindac results in increased expression of PLXNA3 mRNA CTD PMID:11906190 NCBI chr  X:152,115,699...152,131,608
Ensembl chr  X:152,115,819...152,131,603
JBrowse link
G Pml PML nuclear body scaffold increases expression ISO Sulindac results in increased expression of PML mRNA CTD PMID:16273229 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Pole4 DNA polymerase epsilon 4, accessory subunit decreases expression EXP Sulindac results in decreased expression of POLE4 mRNA CTD PMID:24136188 NCBI chr 4:115,165,285...115,171,097
Ensembl chr 4:115,165,285...115,171,097
JBrowse link
G Polr2c RNA polymerase II subunit C decreases expression EXP Sulindac results in decreased expression of POLR2C mRNA CTD PMID:24136188 NCBI chr19:10,158,153...10,164,935
Ensembl chr19:10,157,823...10,164,945
JBrowse link
G Pomp proteasome maturation protein decreases expression EXP Sulindac results in decreased expression of POMP mRNA CTD PMID:24136188 NCBI chr12:7,162,098...7,174,737
Ensembl chr12:7,160,714...7,174,715
JBrowse link
G Pon3 paraoxonase 3 decreases expression EXP Sulindac results in decreased expression of PON3 mRNA CTD PMID:24136188 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression
affects response to substance
ISO Sulindac results in increased expression of PPARD protein
PPARD protein affects the susceptibility to Sulindac
CTD PMID:10866668 PMID:21400612 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta increases expression EXP Sulindac results in increased expression of PPP2CB mRNA CTD PMID:24136188 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Ppp6r1 protein phosphatase 6, regulatory subunit 1 decreases expression EXP Sulindac results in decreased expression of PPP6R1 mRNA CTD PMID:24136188 NCBI chr 1:69,190,856...69,217,598
Ensembl chr 1:69,189,822...69,216,272
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 decreases expression EXP Sulindac results in decreased expression of PPT1 mRNA CTD PMID:24136188 NCBI chr 5:135,121,176...135,141,076
Ensembl chr 5:135,121,163...135,142,048
JBrowse link
G Prdm15 PR/SET domain 15 increases expression EXP Sulindac results in increased expression of PRDM15 mRNA CTD PMID:24136188 NCBI chr11:37,164,608...37,225,172
Ensembl chr11:37,165,575...37,222,207
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP Sulindac results in increased expression of PRDX1 mRNA CTD PMID:24136188 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PRKAA2 mRNA CTD PMID:20371263 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PRKACA mRNA CTD PMID:20371263 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PRKACB mRNA CTD PMID:20371263 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
JBrowse link
G Prkci protein kinase C, iota increases expression EXP Sulindac results in increased expression of PRKCI mRNA CTD PMID:24136188 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352
JBrowse link
G Prodh1 proline dehydrogenase 1 decreases expression EXP Sulindac results in decreased expression of PRODH mRNA CTD PMID:24136188 NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305
JBrowse link
G Prorp protein only RNase P catalytic subunit increases expression EXP Sulindac results in increased expression of PRORP mRNA CTD PMID:24136188 NCBI chr 6:72,669,659...72,762,419
Ensembl chr 6:72,670,847...72,762,416
JBrowse link
G Psma5 proteasome 20S subunit alpha 5 decreases expression EXP Sulindac results in decreased expression of PSMA5 mRNA CTD PMID:24136188 NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731
JBrowse link
G Psmb5 proteasome 20S subunit beta 5 increases expression EXP Sulindac results in increased expression of PSMB5 mRNA CTD PMID:24136188 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 increases expression EXP Sulindac results in increased expression of PSMC2 mRNA CTD PMID:24136188 NCBI chr 4:13,255,851...13,270,102
Ensembl chr 4:13,255,856...13,270,185
JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 decreases expression EXP Sulindac results in decreased expression of PSMC5 mRNA CTD PMID:24136188 NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135
JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 increases expression EXP Sulindac results in increased expression of PSMC6 mRNA CTD PMID:24136188 NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
increases expression
EXP Sulindac results in decreased expression of PTGS1 mRNA alternative form
Sulindac results in increased expression of PTGS1 mRNA
CTD PMID:11375891 PMID:12586211 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases expression
decreases activity
ISO
EXP
[Sulindac co-treated with Deferoxamine] results in increased expression of PTGS2 protein; Sulindac inhibits the reaction [Mitomycin results in increased expression of PTGS2 protein]; Sulindac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Sulindac promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]
Sulindac results in increased expression of PTGS2 mRNA
Sulindac results in decreased expression of PTGS2 mRNA
Sulindac results in decreased activity of PTGS2 protein
[Olive Oil co-treated with Sulindac] results in decreased expression of PTGS2 protein; epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]]; Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]
Sulindac results in decreased expression of PTGS2 protein
CTD PMID:10706128 PMID:11375891 PMID:11504793 PMID:11910360 PMID:12586211 More... NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptp4a2 protein tyrosine phosphatase 4A2 increases expression EXP Sulindac results in increased expression of PTP4A2 mRNA CTD PMID:24136188 NCBI chr 5:142,165,405...142,192,412
Ensembl chr 5:142,165,700...142,191,899
JBrowse link
G Ptprn protein tyrosine phosphatase, receptor type, N decreases expression EXP Sulindac results in decreased expression of PTPRN mRNA CTD PMID:24136188 NCBI chr 9:76,741,010...76,756,704
Ensembl chr 9:76,741,016...76,756,190
JBrowse link
G Pus10 pseudouridine synthase 10 increases expression EXP Sulindac results in increased expression of PUS10 mRNA CTD PMID:24136188 NCBI chr14:97,621,228...97,684,059
Ensembl chr14:97,621,391...97,684,046
JBrowse link
G Qtrt1 queuine tRNA-ribosyltransferase catalytic subunit 1 decreases expression EXP Sulindac results in decreased expression of QTRT1 mRNA CTD PMID:24136188 NCBI chr 8:19,965,801...19,973,843
Ensembl chr 8:19,966,336...19,973,837
JBrowse link
G Rab28 RAB28, member RAS oncogene family increases expression EXP Sulindac results in increased expression of RAB28 mRNA CTD PMID:24136188 NCBI chr14:69,245,846...69,322,968
Ensembl chr14:69,245,854...69,322,967
JBrowse link
G Rab2b RAB2B, member RAS oncogene family increases expression EXP Sulindac results in increased expression of RAB2B mRNA CTD PMID:24136188 NCBI chr15:24,968,364...24,988,990
Ensembl chr15:24,968,803...24,989,113
JBrowse link
G Rac2 Rac family small GTPase 2 decreases expression EXP Sulindac results in decreased expression of RAC2 mRNA CTD PMID:24136188 NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720
JBrowse link
G Ramac RNA guanine-7 methyltransferase activating subunit decreases expression EXP Sulindac results in decreased expression of RAMAC mRNA CTD PMID:24136188 NCBI chr 1:135,708,529...135,714,417
Ensembl chr 1:135,708,535...135,722,151
JBrowse link
G Rasa1 RAS p21 protein activator 1 decreases expression EXP Sulindac results in decreased expression of RASA1 mRNA CTD PMID:24136188 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
JBrowse link
G Rassf6 Ras association domain family member 6 increases expression EXP Sulindac results in increased expression of RASSF6 mRNA CTD PMID:24136188 NCBI chr14:17,433,328...17,473,565
Ensembl chr14:17,442,789...17,473,330
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Sulindac results in decreased expression of RB1 protein CTD PMID:16488075 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbbp7 RB binding protein 7, chromatin remodeling factor increases expression EXP Sulindac results in increased expression of RBBP7 mRNA CTD PMID:24136188 NCBI chr  X:31,913,080...31,931,245
Ensembl chr  X:31,913,081...31,931,226
JBrowse link
G Rbm42 RNA binding motif protein 42 decreases expression EXP Sulindac results in decreased expression of RBM42 mRNA CTD PMID:24136188 NCBI chr 1:85,898,618...85,908,569
Ensembl chr 1:85,898,625...85,908,573
JBrowse link
G Rbm45 RNA binding motif protein 45 increases expression EXP Sulindac results in increased expression of RBM45 mRNA CTD PMID:24136188 NCBI chr 3:61,305,973...61,320,950
Ensembl chr 3:61,305,924...61,320,952
JBrowse link
G Rbm47 RNA binding motif protein 47 decreases expression EXP Sulindac results in decreased expression of RBM47 mRNA CTD PMID:24136188 NCBI chr14:42,053,290...42,191,572
Ensembl chr14:42,154,142...42,189,431
JBrowse link
G Rbx1 ring-box 1 increases expression EXP Sulindac results in increased expression of RBX1 mRNA CTD PMID:24136188 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
increases activity
increases expression
multiple interactions
ISO Sulindac affects the localization of RELA protein
Sulindac results in increased activity of RELA protein
Sulindac results in increased expression of RELA mRNA
[[Sulindac co-treated with Arsenic Trioxide] results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein] which affects the localization of RELA protein; Sulindac inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Sulindac inhibits the reaction [TNF protein results in increased activity of RELA protein]
CTD PMID:10328874 PMID:15489888 PMID:16159934 PMID:16273229 PMID:18059344 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin multiple interactions
decreases activity
ISO Sulindac inhibits the reaction [Furosemide results in increased expression of REN protein]
Sulindac results in decreased activity of REN protein
CTD PMID:2203262 PMID:3884224 PMID:4028619 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Ret ret proto-oncogene affects expression ISO Sulindac affects the expression of RET protein CTD PMID:12388792 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
JBrowse link
G RGD1306063 similar to HT021 decreases expression EXP Sulindac results in decreased expression of RGD1306063 mRNA CTD PMID:24136188 NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838
JBrowse link
G RGD1308147 similar to expressed sequence AW209491 decreases expression EXP Sulindac results in decreased expression of RGD1308147 mRNA CTD PMID:24136188 NCBI chr17:50,543,226...50,550,462
Ensembl chr17:50,542,858...50,549,976
JBrowse link
G RGD1311745 similar to RIKEN cDNA 1110059G10 increases expression EXP Sulindac results in increased expression of RGD1311745 mRNA CTD PMID:24136188 NCBI chr 8:122,598,363...122,609,127
Ensembl chr 8:122,598,401...122,609,168
JBrowse link
G RGD1560065 similar to RIKEN cDNA 2410004B18 increases expression ISO Sulindac results in increased expression of C1ORF52 mRNA CTD PMID:11906190 NCBI chr 2:234,853,378...234,860,045
Ensembl chr 2:234,853,410...234,860,040
JBrowse link
G RGD1562987 similar to cDNA sequence BC031181 decreases expression EXP Sulindac results in decreased expression of RGD1562987 mRNA CTD PMID:24136188 NCBI chr18:68,586,278...68,594,851
Ensembl chr18:68,586,211...68,596,787
JBrowse link
G RGD1565784 RGD1565784 increases expression EXP Sulindac results in increased expression of RGD1565784 mRNA CTD PMID:24136188 NCBI chr10:14,202,217...14,203,519
Ensembl chr10:14,202,243...14,204,029
JBrowse link
G Rgp1 RGP1 homolog, RAB6A GEF complex partner 1 increases expression EXP Sulindac results in increased expression of RGP1 mRNA CTD PMID:24136188 NCBI chr 5:57,834,467...57,843,087
Ensembl chr 5:57,834,629...57,843,086
JBrowse link
G Rmdn3 regulator of microtubule dynamics 3 decreases expression EXP Sulindac results in decreased expression of RMDN3 mRNA CTD PMID:24136188 NCBI chr 3:106,125,961...106,146,568
Ensembl chr 3:106,125,951...106,146,586
JBrowse link
G Rnase1 ribonuclease A family member 1, pancreatic decreases expression ISO Sulindac results in decreased expression of RNASE1 mRNA CTD PMID:11906190 NCBI chr15:24,361,924...24,363,658
Ensembl chr15:24,361,927...24,363,624
JBrowse link
G Rnf220 ring finger protein 220 increases expression EXP Sulindac results in increased expression of RNF220 mRNA CTD PMID:24136188 NCBI chr 5:130,739,173...130,961,386
Ensembl chr 5:130,739,183...130,961,418
JBrowse link
G Rnf26 ring finger protein 26 decreases expression ISO Sulindac results in decreased expression of RNF26 mRNA CTD PMID:11906190 NCBI chr 8:44,454,551...44,456,745
Ensembl chr 8:44,454,292...44,457,331
JBrowse link
G Rnpepl1 arginyl aminopeptidase like 1 decreases expression EXP Sulindac results in decreased expression of RNPEPL1 mRNA CTD PMID:24136188 NCBI chr 9:93,476,600...93,486,331
Ensembl chr 9:93,472,390...93,486,331
JBrowse link
G Rpia ribose 5-phosphate isomerase A decreases expression EXP Sulindac results in decreased expression of RPIA mRNA CTD PMID:24136188 NCBI chr 4:102,723,712...102,749,374
Ensembl chr 4:102,723,712...102,749,355
JBrowse link
G Rragc Ras-related GTP binding C decreases expression EXP Sulindac results in decreased expression of RRAGC mRNA CTD PMID:24136188 NCBI chr 5:136,148,239...136,167,773
Ensembl chr 5:136,148,276...136,167,767
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of RXRA mRNA CTD PMID:20371263 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression EXP Sulindac results in decreased expression of SAE1 mRNA CTD PMID:24136188 NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
JBrowse link
G Sap30l SAP30-like decreases expression EXP Sulindac results in decreased expression of SAP30L mRNA CTD PMID:24136188 NCBI chr10:41,980,151...41,992,307
Ensembl chr10:41,979,687...41,987,658
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO Sulindac results in increased expression of SAT1 mRNA CTD PMID:14506281 PMID:16262603 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 increases activity
increases expression
ISO Sulindac results in increased activity of SAT2 protein
Sulindac results in increased expression of SAT2 mRNA
CTD PMID:17474863 NCBI chr10:54,340,756...54,343,507
Ensembl chr10:54,340,372...54,343,224
JBrowse link
G Scamp1 secretory carrier membrane protein 1 increases expression EXP Sulindac results in increased expression of SCAMP1 mRNA CTD PMID:24136188 NCBI chr 2:25,433,958...25,516,734
Ensembl chr 2:25,433,959...25,516,673
JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 increases expression EXP Sulindac results in increased expression of SCO1 mRNA CTD PMID:24136188 NCBI chr10:51,744,656...51,757,246
Ensembl chr10:51,744,656...51,757,237
JBrowse link
G Sdhaf3 succinate dehydrogenase complex assembly factor 3 increases expression EXP Sulindac results in increased expression of SDHAF3 mRNA CTD PMID:24136188 NCBI chr 4:35,143,131...35,160,416
Ensembl chr 4:35,100,506...35,160,749
JBrowse link
G Sec62 SEC62 homolog, preprotein translocation factor decreases expression EXP Sulindac results in decreased expression of SEC62 mRNA CTD PMID:24136188 NCBI chr 2:112,570,810...112,607,576
Ensembl chr 2:112,570,819...112,601,814
JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator decreases expression EXP Sulindac results in decreased expression of SEC63 mRNA CTD PMID:24136188 NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055
JBrowse link
G Septin10 septin 10 decreases expression EXP Sulindac results in decreased expression of SEPTIN10 mRNA CTD PMID:24136188 NCBI chr20:27,101,764...27,194,997
Ensembl chr20:27,101,752...27,194,780
JBrowse link
G Serpinb1a serpin family B member 1A increases expression ISO Sulindac results in increased expression of SERPINB1 mRNA CTD PMID:11507085 NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
JBrowse link
G Set SET nuclear proto-oncogene decreases expression EXP Sulindac results in decreased expression of SET mRNA CTD PMID:24136188 NCBI chr19:53,561,262...53,562,780
Ensembl chr19:53,561,190...53,563,819
JBrowse link
G Sft2d2 SFT2 domain containing 2 increases expression EXP Sulindac results in increased expression of SFT2D2 mRNA CTD PMID:24136188 NCBI chr13:77,484,778...77,504,123
Ensembl chr13:77,484,636...77,504,112
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SHC1 mRNA] CTD PMID:15190207 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 increases expression EXP Sulindac results in increased expression of SHMT2 mRNA CTD PMID:24136188 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236
JBrowse link
G Sirt1 sirtuin 1 increases expression ISO Sulindac results in increased expression of SIRT1 mRNA CTD PMID:11906190 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc16a6 solute carrier family 16, member 6 increases expression ISO Sulindac results in increased expression of SLC16A6 mRNA CTD PMID:11906190 NCBI chr10:94,424,377...94,447,984
Ensembl chr10:94,426,244...94,448,779
JBrowse link
G Slc18b1 solute carrier family 18 member B1 increases expression EXP Sulindac results in increased expression of SLC18B1 mRNA CTD PMID:24136188 NCBI chr 1:21,628,232...21,670,807
Ensembl chr 1:21,628,237...21,670,684
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Sulindac results in decreased activity of SLC22A1 protein CTD PMID:12388633 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Sulindac results in decreased activity of SLC22A2 protein CTD PMID:12388633 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity ISO Sulindac results in decreased activity of SLC22A9 protein CTD PMID:12388633 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Sulindac results in decreased activity of SLC22A6 protein CTD PMID:12388633 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases activity ISO Sulindac results in decreased activity of SLC22A7 protein CTD PMID:12388633 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc27a4 solute carrier family 27 member 4 decreases expression EXP Sulindac results in decreased expression of SLC27A4 mRNA CTD PMID:24136188 NCBI chr 3:13,075,022...13,087,943
Ensembl chr 3:13,075,022...13,087,943
JBrowse link
G Slc30a1 solute carrier family 30 member 1 increases expression ISO Sulindac results in increased expression of SLC30A1 mRNA CTD PMID:11906190 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
JBrowse link
G Slc30a5 solute carrier family 30 member 5 decreases expression EXP Sulindac results in decreased expression of SLC30A5 mRNA CTD PMID:24136188 NCBI chr 2:31,945,745...31,975,969
Ensembl chr 2:31,945,729...31,975,934
JBrowse link
G Slc38a2 solute carrier family 38, member 2 increases expression ISO Sulindac results in increased expression of SLC38A2 mRNA CTD PMID:11906190 NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436
JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO Sulindac results in increased expression of SLC3A2 mRNA CTD PMID:11906190 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G Slc4a1ap solute carrier family 4 member 1 adaptor protein decreases expression EXP Sulindac results in decreased expression of SLC4A1AP mRNA CTD PMID:24136188 NCBI chr 6:24,905,941...24,933,651
Ensembl chr 6:24,905,941...24,933,815
JBrowse link
G Slc7a1 solute carrier family 7 member 1 increases expression ISO Sulindac results in increased expression of SLC7A1 mRNA CTD PMID:11906190 NCBI chr12:6,628,214...6,703,849
Ensembl chr12:6,628,007...6,703,849
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SLCO1A2 mRNA CTD PMID:20371263 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slfn3 schlafen family member 3 decreases expression EXP Sulindac results in decreased expression of SLFN3 mRNA CTD PMID:24136188 NCBI chr10:68,020,482...68,060,248 JBrowse link
G Smc1a structural maintenance of chromosomes 1A decreases expression EXP Sulindac results in decreased expression of SMC1A mRNA CTD PMID:24136188 NCBI chr  X:21,103,323...21,148,053
Ensembl chr  X:21,103,282...21,148,056
JBrowse link
G Smu1 SMU1, DNA replication regulator and spliceosomal factor decreases expression EXP Sulindac results in decreased expression of SMU1 mRNA CTD PMID:24136188 NCBI chr 5:55,856,691...55,875,262
Ensembl chr 5:55,856,246...55,875,300
JBrowse link
G Snrnp27 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 increases expression EXP Sulindac results in increased expression of SNRNP27 mRNA CTD PMID:24136188 NCBI chr 4:119,123,676...119,133,234
Ensembl chr 4:119,121,877...119,133,234
JBrowse link
G Snx21 sorting nexin family member 21 increases expression ISO Sulindac results in increased expression of SNX21 mRNA CTD PMID:11906190 NCBI chr 3:153,521,748...153,532,235 JBrowse link
G Snx25 sorting nexin 25 increases expression ISO Sulindac results in increased expression of SNX25 mRNA CTD PMID:11906190 NCBI chr16:46,134,552...46,238,471
Ensembl chr16:46,125,804...46,238,440
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Sulindac inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SOD2 mRNA] CTD PMID:15190207 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spred3 sprouty-related, EVH1 domain containing 3 decreases expression EXP Sulindac results in decreased expression of SPRED3 mRNA CTD PMID:24136188 NCBI chr 1:84,458,779...84,470,425
Ensembl chr 1:84,459,314...84,470,249
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Sulindac results in increased expression of SQSTM1 mRNA CTD PMID:11906190 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP
ISO
[[Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein] which results in increased phosphorylation of and results in decreased activity of SRC protein
Sulindac results in increased phosphorylation of and results in decreased activity of SRC protein
CTD PMID:18644992 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Sulindac results in increased expression of SRXN1 protein CTD PMID:27358234 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Ss18 SS18 subunit of BAF chromatin remodeling complex decreases expression EXP Sulindac results in decreased expression of SS18 mRNA CTD PMID:24136188 NCBI chr18:5,773,042...5,835,696
Ensembl chr18:5,773,042...5,835,333
JBrowse link
G Ssu72 SSU72 homolog, RNA polymerase II CTD phosphatase decreases expression EXP Sulindac results in decreased expression of SSU72 mRNA CTD PMID:24136188 NCBI chr 5:166,312,267...166,343,432
Ensembl chr 5:166,313,650...166,343,429
JBrowse link
G Stac3 SH3 and cysteine rich domain 3 decreases expression EXP Sulindac results in decreased expression of STAC3 mRNA CTD PMID:24136188 NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589
JBrowse link
G Stard3 StAR-related lipid transfer domain containing 3 increases expression EXP Sulindac results in increased expression of STARD3 mRNA CTD PMID:24136188 NCBI chr10:83,357,329...83,379,873
Ensembl chr10:83,357,359...83,550,976
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression
decreases phosphorylation
ISO BIRC5 protein inhibits the reaction [Sulindac results in decreased expression of STAT3 protein modified form]; BIRC5 protein inhibits the reaction [Sulindac results in decreased expression of STAT3 protein]
Sulindac results in decreased expression of STAT3 protein; Sulindac results in decreased expression of STAT3 protein modified form
Sulindac results in decreased phosphorylation of STAT3 protein
CTD PMID:11861373 PMID:17401459 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Sulindac results in increased expression of STC2 mRNA CTD PMID:11906190 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Stoml2 stomatin like 2 increases expression EXP Sulindac results in increased expression of STOML2 mRNA CTD PMID:24136188 NCBI chr 5:57,256,227...57,259,824
Ensembl chr 5:57,256,220...57,259,920
JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression EXP Sulindac results in increased expression of STRBP mRNA CTD PMID:24136188 NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949
JBrowse link
G Stx7 syntaxin 7 decreases expression EXP Sulindac results in decreased expression of STX7 mRNA CTD PMID:24136188 NCBI chr 1:21,197,075...21,237,320
Ensembl chr 1:21,197,075...21,237,279
JBrowse link
G Stxbp2 syntaxin binding protein 2 increases expression ISO Sulindac results in increased expression of STXBP2 mRNA CTD PMID:11906190 NCBI chr12:1,689,364...1,701,145
Ensembl chr12:1,689,410...1,700,458
JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha increases expression EXP Sulindac results in increased expression of SUCLG1 mRNA CTD PMID:24136188 NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SULT1B1 mRNA CTD PMID:20371263 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions
decreases activity
EXP
ISO
[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SULT1E1 mRNA
Sulindac results in decreased activity of SULT1E1 protein
CTD PMID:17073578 PMID:20371263 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Sumo3 small ubiquitin-like modifier 3 decreases expression ISO Sulindac results in decreased expression of SUMO3 mRNA CTD PMID:11906190 NCBI chr20:11,010,140...11,020,850
Ensembl chr20:11,010,166...11,020,696
JBrowse link
G Sun2 Sad1 and UNC84 domain containing 2 decreases expression ISO Sulindac results in decreased expression of SUN2 mRNA CTD PMID:11906190 NCBI chr 7:111,275,374...111,292,565
Ensembl chr 7:111,275,380...111,292,553
JBrowse link
G Supt7l SPT7 like, STAGA complex subunit gamma decreases expression EXP Sulindac results in decreased expression of SUPT7L mRNA CTD PMID:24136188 NCBI chr 6:24,933,941...24,944,656
Ensembl chr 6:24,933,923...24,944,654
JBrowse link
G Syp synaptophysin decreases expression EXP Sulindac results in decreased expression of SYP mRNA CTD PMID:24136188 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Syt15 synaptotagmin 15 decreases expression EXP Sulindac results in decreased expression of SYT15 mRNA CTD PMID:24136188 NCBI chr16:9,532,478...9,543,288
Ensembl chr16:9,532,478...9,543,281
JBrowse link
G Tbc1d10b TBC1 domain family, member 10b increases expression ISO Sulindac results in increased expression of TBC1D10B mRNA CTD PMID:11906190 NCBI chr 1:181,814,972...181,826,628
Ensembl chr 1:181,814,972...181,826,628
JBrowse link
G Tbk1 TANK-binding kinase 1 increases expression ISO Sulindac results in increased expression of TBK1 mRNA CTD PMID:11093808 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
JBrowse link
G Tbx3 T-box transcription factor 3 increases expression ISO Sulindac results in increased expression of TBX3 mRNA CTD PMID:11906190 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
JBrowse link
G Tceanc2 transcription elongation factor A N-terminal and central domain containing 2 increases expression EXP Sulindac results in increased expression of TCEANC2 mRNA CTD PMID:24136188 NCBI chr 5:121,923,959...121,963,018
Ensembl chr 5:121,923,956...121,962,183
JBrowse link
G Tcf4 transcription factor 4 decreases activity
multiple interactions
ISO Sulindac results in decreased activity of TCF4 protein
TCF4 protein promotes the reaction [Sulindac results in increased susceptibility to TNFSF10 protein]
CTD PMID:11593435 PMID:21171083 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity
multiple interactions
EXP Sulindac results in decreased activity of TDO2 protein
[Sulindac results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine; [Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin
CTD PMID:16952380 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions ISO Sulindac analog results in decreased phosphorylation of and results in decreased activity of TEK protein CTD PMID:16215210 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
JBrowse link
G Tfdp1 transcription factor Dp-1 decreases expression EXP Sulindac results in decreased expression of TFDP1 mRNA CTD PMID:24136188 NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Sulindac results in increased expression of TGFB1 protein CTD PMID:11496082 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of TGM2 mRNA] CTD PMID:15190207 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Thap7 THAP domain containing 7 increases expression EXP Sulindac results in increased expression of THAP7 mRNA CTD PMID:24136188 NCBI chr11:83,482,958...83,486,136
Ensembl chr11:83,483,037...83,486,436
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Sulindac results in decreased expression of THRSP mRNA CTD PMID:24136188 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Timm10 translocase of inner mitochondrial membrane 10 increases expression EXP Sulindac results in increased expression of TIMM10 mRNA CTD PMID:24136188 NCBI chr 3:69,908,397...69,911,943
Ensembl chr 3:69,908,456...69,911,940
JBrowse link
G Timmdc1 translocase of inner mitochondrial membrane domain containing 1 increases expression EXP Sulindac results in increased expression of TIMMDC1 mRNA CTD PMID:24136188 NCBI chr11:62,228,990...62,259,389
Ensembl chr11:62,229,058...62,254,699
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression ISO Sulindac affects the expression of TIMP1 protein CTD PMID:12388792 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 multiple interactions ISO [Sulindac co-treated with epigallocatechin gallate] results in decreased expression of TIMP3 mRNA CTD PMID:12628509 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Tjp2 tight junction protein 2 increases expression EXP Sulindac results in increased expression of TJP2 mRNA CTD PMID:24136188 NCBI chr 1:221,709,745...221,838,383
Ensembl chr 1:221,709,745...221,838,295
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of TLR2 mRNA CTD PMID:20371263 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tm2d1 TM2 domain containing 1 increases expression EXP Sulindac results in increased expression of TM2D1 mRNA CTD PMID:24136188 NCBI chr 5:113,020,760...113,062,370
Ensembl chr 5:113,020,760...113,050,933
JBrowse link
G Tm7sf3 transmembrane 7 superfamily member 3 decreases expression ISO Sulindac results in decreased expression of TM7SF3 mRNA CTD PMID:11093808 NCBI chr 4:179,518,127...179,550,154
Ensembl chr 4:179,518,130...179,550,154
JBrowse link
G Tmed9 transmembrane p24 trafficking protein 9 decreases expression ISO Sulindac results in decreased expression of TMED9 mRNA CTD PMID:11906190 NCBI chr17:9,029,646...9,034,160
Ensembl chr17:9,029,646...9,034,176
JBrowse link
G Tmem127 transmembrane protein 127 increases expression ISO Sulindac results in increased expression of TMEM127 mRNA CTD PMID:11906190 NCBI chr 3:114,466,095...114,478,894
Ensembl chr 3:114,466,171...114,477,519
JBrowse link
G Tmem141 transmembrane protein 141 increases expression EXP Sulindac results in increased expression of TMEM141 mRNA CTD PMID:24136188 NCBI chr 3:8,439,533...8,441,491
Ensembl chr 3:8,439,533...8,441,491
JBrowse link
G Tmem209 transmembrane protein 209 decreases expression EXP Sulindac results in decreased expression of TMEM209 mRNA CTD PMID:24136188 NCBI chr 4:59,101,656...59,128,687
Ensembl chr 4:59,101,550...59,128,630
JBrowse link
G Tmem39a transmembrane protein 39a increases expression ISO Sulindac results in increased expression of TMEM39A mRNA CTD PMID:11906190 NCBI chr11:62,160,631...62,189,964
Ensembl chr11:62,160,631...62,189,964
JBrowse link
G Tmem60 transmembrane protein 60 increases expression EXP Sulindac results in increased expression of TMEM60 mRNA CTD PMID:24136188 NCBI chr 4:14,210,029...14,214,884
Ensembl chr 4:14,210,029...14,215,063
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression EXP
ISO
Sulindac results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Tmx1 thioredoxin-related transmembrane protein 1 increases expression EXP Sulindac results in increased expression of TMX1 mRNA CTD PMID:24136188 NCBI chr 6:88,960,724...88,971,301
Ensembl chr 6:88,960,695...88,971,301
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Sulindac inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Sulindac inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulindac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Sulindac inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Sulindac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Sulindac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
Sulindac results in increased expression of TNF
[Sulindac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein; Sulindac inhibits the reaction [Okadaic Acid results in increased expression of TNF protein]
CTD PMID:10328874 PMID:10757128 PMID:15489888 PMID:16159934 PMID:17328244 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance
multiple interactions
ISO Sulindac results in increased susceptibility to TNFSF10 protein
[Sulindac co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; TCF4 protein promotes the reaction [Sulindac results in increased susceptibility to TNFSF10 protein]
CTD PMID:21171083 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tns3 tensin 3 decreases expression ISO Sulindac results in decreased expression of TNS3 mRNA CTD PMID:11906190 NCBI chr14:83,173,649...83,405,671
Ensembl chr14:83,173,649...83,405,998
JBrowse link
G Tor1a torsin family 1, member A decreases expression EXP Sulindac results in decreased expression of TOR1A mRNA CTD PMID:24136188 NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691
JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression
increases expression
affects localization
ISO [Sulindac results in increased abundance of Reactive Oxygen Species] which results in increased activity of TP53 protein; SB 203580 inhibits the reaction [Sulindac affects the localization of TP53 protein]
Sulindac results in decreased expression of TRP53 protein
Sulindac results in increased expression of TP53 protein
CTD PMID:15020200 PMID:15713900 PMID:17136320 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpra1 transmembrane protein adipocyte associated 1 increases expression ISO Sulindac results in increased expression of TPRA1 mRNA CTD PMID:11906190 NCBI chr 4:121,364,093...121,375,275
Ensembl chr 4:121,364,091...121,375,269
JBrowse link
G Trim2 tripartite motif-containing 2 increases expression ISO Sulindac results in increased expression of TRIM2 mRNA CTD PMID:11906190 NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927
JBrowse link
G Trit1 tRNA isopentenyltransferase 1 decreases expression ISO Sulindac results in decreased expression of TRIT1 mRNA CTD PMID:11906190 NCBI chr 5:135,293,472...135,341,522
Ensembl chr 5:135,295,330...135,338,764
JBrowse link
G Trub2 TruB pseudouridine synthase family member 2 increases expression EXP Sulindac results in increased expression of TRUB2 mRNA CTD PMID:24136188 NCBI chr 3:13,049,220...13,059,836
Ensembl chr 3:13,033,745...13,059,930
JBrowse link
G Tsnax translin-associated factor X decreases expression ISO Sulindac results in decreased expression of TSNAX mRNA CTD PMID:11906190 NCBI chr19:52,975,848...52,989,886
Ensembl chr19:52,975,659...52,989,878
JBrowse link
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator increases expression EXP Sulindac results in increased expression of TUSC2 mRNA CTD PMID:24136188 NCBI chr 8:108,236,838...108,240,056
Ensembl chr 8:108,236,838...108,240,056
JBrowse link
G Txn1 thioredoxin 1 increases response to substance ISO TXN1 results in increased susceptibility to Sulindac analog CTD PMID:18922898 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txnl1 thioredoxin-like 1 increases expression EXP Sulindac results in increased expression of TXNL1 mRNA CTD PMID:24136188 NCBI chr18:57,125,362...57,155,167
Ensembl chr18:57,125,369...57,165,266
JBrowse link
G Tyw1 tRNA-yW synthesizing protein 1 homolog increases expression EXP Sulindac results in increased expression of TYW1 mRNA CTD PMID:24136188 NCBI chr12:26,332,020...26,418,286
Ensembl chr12:26,330,351...26,418,208
JBrowse link
G Ube2e3 ubiquitin-conjugating enzyme E2E 3 decreases expression EXP Sulindac results in decreased expression of UBE2E3 mRNA CTD PMID:24136188 NCBI chr 3:63,786,976...63,851,400
Ensembl chr 3:63,786,650...63,843,237
JBrowse link
G Ube3a ubiquitin protein ligase E3A increases expression EXP Sulindac results in increased expression of UBE3A mRNA CTD PMID:24136188 NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250
JBrowse link
G Ubl5 ubiquitin-like 5 decreases expression EXP Sulindac results in decreased expression of UBL5 mRNA CTD PMID:24136188 NCBI chr 8:19,183,437...19,185,223
Ensembl chr 8:19,181,615...19,185,217
JBrowse link
G Ubqln2 ubiquilin 2 increases expression EXP Sulindac results in increased expression of UBQLN2 mRNA CTD PMID:24136188 NCBI chr  X:17,853,086...17,856,505
Ensembl chr  X:17,853,114...17,856,505
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 decreases expression EXP Sulindac results in decreased expression of UFD1 mRNA CTD PMID:24136188 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087
JBrowse link
G Ufl1 Ufm1-specific ligase 1 increases expression EXP Sulindac results in increased expression of UFL1 mRNA CTD PMID:24136188 NCBI chr 5:38,962,721...38,995,134
Ensembl chr 5:38,962,171...38,995,199
JBrowse link
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 increases expression ISO Sulindac results in increased expression of UGGT2 mRNA CTD PMID:11906190 NCBI chr15:96,074,557...96,239,365
Ensembl chr15:96,074,564...96,237,806
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity
increases glucuronidation
increases expression
ISO Sulindac results in increased activity of UGT1A1 protein
UGT1A1 protein results in increased glucuronidation of Sulindac
Sulindac results in increased expression of UGT1A1 mRNA
CTD PMID:15843492 PMID:17985343 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Sulindac CTD PMID:15843492 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Sulindac CTD PMID:15843492 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Sulindac CTD PMID:15843492 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO Sulindac results in decreased expression of UNG mRNA CTD PMID:11906190 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
JBrowse link
G Uqcc2 ubiquinol-cytochrome c reductase complex assembly factor 2 decreases expression EXP Sulindac results in decreased expression of UQCC2 mRNA CTD PMID:24136188 NCBI chr20:5,202,837...5,214,541
Ensembl chr20:5,202,837...5,214,164
JBrowse link
G Vapb VAMP associated protein B and C increases expression EXP Sulindac results in increased expression of VAPB mRNA CTD PMID:24136188 NCBI chr 3:162,536,090...162,578,738
Ensembl chr 3:162,535,905...162,573,763
JBrowse link
G Vash1 vasohibin 1 decreases expression EXP Sulindac results in decreased expression of VASH1 mRNA CTD PMID:24136188 NCBI chr 6:106,330,374...106,345,740
Ensembl chr 6:106,329,123...106,345,726
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of VCAM1 mRNA CTD PMID:20371263 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vcp valosin-containing protein decreases expression EXP Sulindac results in decreased expression of VCP mRNA CTD PMID:24136188 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link
G Vps26b VPS26 retromer complex component B decreases expression EXP Sulindac results in decreased expression of VPS26B mRNA CTD PMID:24136188 NCBI chr 8:25,415,877...25,436,985
Ensembl chr 8:25,415,261...25,436,985
JBrowse link
G Vps26c VPS26 endosomal protein sorting factor C increases expression EXP Sulindac results in increased expression of VPS26C mRNA CTD PMID:24136188 NCBI chr11:33,813,467...33,841,883
Ensembl chr11:33,792,389...33,841,447
JBrowse link
G Vps29 VPS29 retromer complex component increases expression EXP Sulindac results in increased expression of VPS29 mRNA CTD PMID:24136188 NCBI chr12:34,208,911...34,217,977
Ensembl chr12:34,207,263...34,217,964
JBrowse link
G Vps35 VPS35 retromer complex component decreases expression EXP Sulindac results in decreased expression of VPS35 mRNA CTD PMID:24136188 NCBI chr19:21,765,771...21,801,620
Ensembl chr19:21,765,749...21,801,618
JBrowse link
G Vps53 VPS53 subunit of GARP complex increases expression EXP Sulindac results in increased expression of VPS53 mRNA CTD PMID:24136188 NCBI chr10:60,919,820...61,038,674
Ensembl chr10:60,919,820...61,038,676
JBrowse link
G Wdr3 WD repeat domain 3 increases expression ISO Sulindac results in increased expression of WDR3 mRNA CTD PMID:11906190 NCBI chr 2:187,505,816...187,528,432
Ensembl chr 2:187,505,816...187,528,432
JBrowse link
G Wdr61 WD repeat domain 61 decreases expression EXP Sulindac results in decreased expression of WDR61 mRNA CTD PMID:24136188 NCBI chr 8:55,103,542...55,120,837
Ensembl chr 8:55,103,545...55,120,813
JBrowse link
G Wdr83os WD repeat domain 83 opposite strand increases expression EXP Sulindac results in increased expression of WDR83OS mRNA CTD PMID:24136188 NCBI chr19:23,075,372...23,076,934
Ensembl chr19:23,075,376...23,076,894
JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 decreases expression EXP Sulindac results in decreased expression of WWP1 mRNA CTD PMID:24136188 NCBI chr 5:33,092,379...33,185,887
Ensembl chr 5:33,098,494...33,186,046
JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Sulindac results in increased expression of XBP1 mRNA CTD PMID:11906190 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP protein CTD PMID:17136320 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Xpo1 exportin 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of XPO1 mRNA CTD PMID:20371263 NCBI chr14:97,233,263...97,275,536
Ensembl chr14:97,233,270...97,275,498
JBrowse link
G Xpr1 xenotropic and polytropic retrovirus receptor 1 increases expression EXP Sulindac results in increased expression of XPR1 mRNA CTD PMID:24136188 NCBI chr13:67,441,205...67,585,950
Ensembl chr13:67,446,380...67,585,946
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression EXP Sulindac results in decreased expression of XRCC5 mRNA CTD PMID:24136188 NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018
JBrowse link
G Yme1l1 YME1-like 1 ATPase decreases expression EXP Sulindac results in decreased expression of YME1L1 mRNA CTD PMID:24136188 NCBI chr17:85,287,607...85,326,068
Ensembl chr17:85,287,554...85,326,335
JBrowse link
G Ythdf3 YTH N(6)-methyladenosine RNA binding protein 3 increases expression EXP Sulindac results in increased expression of YTHDF3 mRNA CTD PMID:24136188 NCBI chr 2:98,350,304...98,384,608
Ensembl chr 2:98,350,588...98,384,606
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta increases expression EXP Sulindac results in increased expression of YWHAB mRNA CTD PMID:24136188 NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon increases expression EXP Sulindac results in increased expression of YWHAE mRNA CTD PMID:24136188 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
JBrowse link
G Zc3h13 zinc finger CCCH type containing 13 increases expression EXP Sulindac results in increased expression of ZC3H13 mRNA CTD PMID:24136188 NCBI chr15:50,607,335...50,671,802
Ensembl chr15:50,607,380...50,671,802
JBrowse link
G Zfp106 zinc finger protein 106 decreases expression EXP Sulindac results in decreased expression of ZFP106 mRNA CTD PMID:24136188 NCBI chr 3:107,459,232...107,510,494
Ensembl chr 3:107,462,096...107,510,481
JBrowse link
G Zfp148 zinc finger protein 148 decreases expression EXP Sulindac results in decreased expression of ZFP148 mRNA CTD PMID:24136188 NCBI chr11:67,276,455...67,385,803
Ensembl chr11:67,281,707...67,385,772
JBrowse link
G Zfp281 zinc finger protein 281 increases expression EXP Sulindac results in increased expression of ZFP281 mRNA CTD PMID:24136188 NCBI chr13:48,096,103...48,104,265
Ensembl chr13:48,037,286...48,104,888
JBrowse link
G Zfp354a zinc finger protein 354A increases expression ISO Sulindac results in increased expression of ZNF354A mRNA CTD PMID:11906190 NCBI chr10:35,396,242...35,408,065
Ensembl chr10:35,396,231...35,408,068
JBrowse link
G Zfp423 zinc finger protein 423 decreases expression EXP Sulindac results in decreased expression of ZFP423 mRNA CTD PMID:24136188 NCBI chr19:19,111,538...19,407,371
Ensembl chr19:19,110,238...19,407,373
JBrowse link
G Znhit1 zinc finger, HIT-type containing 1 increases expression EXP Sulindac results in increased expression of ZNHIT1 mRNA CTD PMID:24136188 NCBI chr12:19,686,606...19,692,880
Ensembl chr12:19,686,148...19,692,880
JBrowse link
G Znhit3 zinc finger, HIT-type containing 3 increases expression EXP Sulindac results in increased expression of ZNHIT3 mRNA CTD PMID:24136188 NCBI chr10:69,775,885...69,790,471
Ensembl chr10:69,780,210...69,790,446
JBrowse link
sulindac sulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO sulindac sulfide results in increased expression of ABCG2 mRNA CTD PMID:16184548 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Actn1 actinin, alpha 1 decreases expression ISO sulindac sulfide results in decreased expression of ACTN1 mRNA CTD PMID:16184548 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 decreases expression ISO sulindac sulfide results in decreased expression of ADAM9 mRNA CTD PMID:16184548 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917
JBrowse link
G Adm adrenomedullin increases expression ISO sulindac sulfide results in increased expression of ADM mRNA CTD PMID:16184548 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Adra2c adrenoceptor alpha 2C decreases expression ISO sulindac sulfide results in decreased expression of ADRA2C mRNA CTD PMID:12734198 NCBI chr14:75,471,143...75,472,846
Ensembl chr14:75,471,143...75,472,846
JBrowse link
G Ahr aryl hydrocarbon receptor increases localization ISO sulindac sulfide results in increased localization of AHR protein CTD PMID:17985343 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akap12 A-kinase anchoring protein 12 increases expression ISO sulindac sulfide results in increased expression of AKAP12 mRNA CTD PMID:12734198 NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO sulindac sulfide results in decreased expression of ALDOC mRNA CTD PMID:16184548 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression ISO sulindac sulfide results in increased expression of ALOX15 protein CTD PMID:16166323 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Anxa5 annexin A5 increases expression ISO sulindac sulfide results in increased expression of ANXA5 protein CTD PMID:18678619 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO sulindac sulfide inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein] CTD PMID:19013290 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G App amyloid beta precursor protein multiple interactions
affects cleavage
ISO
EXP
[sulindac sulfide results in decreased activity of PSEN1 protein] which affects the cleavage of APP protein; PSEN1 protein affects the reaction [sulindac sulfide affects the cleavage of APP protein]; PSEN1 protein mutant form promotes the reaction [sulindac sulfide affects the cleavage of APP protein]; sulindac sulfide affects the cleavage of and affects the localization of APP protein; sulindac sulfide affects the reaction [PSEN1 protein affects the cleavage of APP protein]
sulindac sulfide inhibits the reaction [APP protein results in increased uptake of Calcium]
CTD PMID:11700559 PMID:12637581 PMID:12777371 PMID:12805356 PMID:14690522 More... NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ar androgen receptor multiple interactions ISO AR protein affects the reaction [sulindac sulfide results in decreased expression of KLK3 protein]; sulindac sulfide results in decreased expression of and results in decreased activity of AR protein CTD PMID:14581372 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Areg amphiregulin increases expression ISO sulindac sulfide results in increased expression of AREG mRNA CTD PMID:16184548 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Arl6ip1 ADP-ribosylation factor like GTPase 6 interacting protein 1 decreases expression ISO sulindac sulfide results in decreased expression of ARL6IP1 mRNA CTD PMID:12734198 NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994
JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B decreases expression ISO sulindac sulfide results in decreased expression of ARPC1B mRNA CTD PMID:12734198 NCBI chr12:9,482,176...9,495,772
Ensembl chr12:9,480,831...9,495,747
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 decreases expression ISO sulindac sulfide results in decreased expression of ASAH1 mRNA CTD PMID:16184548 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of ATF3 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of ATF3 protein; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; MAP2K1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]
sulindac sulfide results in increased expression of ATF3 mRNA; sulindac sulfide results in increased expression of ATF3 protein
CTD PMID:12734198 PMID:15897233 PMID:16079301 PMID:16184548 PMID:21554132 More... NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 increases expression ISO sulindac sulfide results in increased expression of ATP6V0A1 mRNA CTD PMID:16184548 NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895
JBrowse link
G Aurka aurora kinase A decreases expression ISO sulindac sulfide results in decreased expression of AURKA mRNA CTD PMID:12734198 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
increases localization
multiple interactions
ISO sulindac sulfide results in decreased expression of BAD protein
sulindac sulfide results in increased localization of BAD protein
[sulindac sulfide results in decreased expression of YWHAE protein] which results in increased localization of BAD protein; sulindac sulfide promotes the reaction [BAD protein binds to YWHAE protein]
CTD PMID:17409426 PMID:18678619 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases response to substance EXP BAK1 results in increased susceptibility to sulindac sulfide CTD PMID:18349538 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
affects response to substance
ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]
sulindac sulfide results in increased expression of BAX mRNA
sulindac sulfide results in decreased expression of BAX protein
BAX protein affects the susceptibility to sulindac sulfide
CTD PMID:12203115 PMID:16886631 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcam basal cell adhesion molecule (Lutheran blood group) decreases expression ISO sulindac sulfide results in decreased expression of BCAM mRNA CTD PMID:12734198 NCBI chr 1:79,415,016...79,429,403
Ensembl chr 1:79,415,017...79,429,403
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases phosphorylation ISO sulindac sulfide results in decreased phosphorylation of BCAR1 protein CTD PMID:10741720 NCBI chr19:39,679,218...39,713,952
Ensembl chr19:39,679,204...39,713,907
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sulindac sulfide results in decreased expression of BCL2 protein CTD PMID:18678619 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO sulindac sulfide results in decreased expression of BCL2L1 protein CTD PMID:11912124 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression
increases cleavage
ISO sulindac sulfide results in decreased expression of BID protein
sulindac sulfide results in increased cleavage of BID protein
CTD PMID:12203115 PMID:16886631 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO sulindac sulfide results in increased expression of BIRC3 mRNA CTD PMID:16184548 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO sulindac sulfide results in decreased expression of BUB1B mRNA CTD PMID:16184548 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
JBrowse link
G Cacng3 calcium voltage-gated channel auxiliary subunit gamma 3 increases expression ISO sulindac sulfide results in increased expression of CACNG3 mRNA CTD PMID:16184548 NCBI chr 1:177,201,990...177,296,473
Ensembl chr 1:177,201,288...177,297,024
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
ISO sulindac sulfide results in increased activity of CASP3 protein
sulindac sulfide results in increased expression of CASP3 mRNA
[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; MAP2K1 protein inhibits the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP3 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]
CTD PMID:11051267 PMID:12203115 PMID:12414664 PMID:14555707 PMID:15548677 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein] CTD PMID:20371263 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP8 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:11559570 PMID:12203115 PMID:12414664 PMID:16886631 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP9 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein] CTD PMID:12203115 PMID:12414664 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 increases expression ISO sulindac sulfide results in increased expression of CCAR1 mRNA CTD PMID:12734198 NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
increases expression
ISO sulindac sulfide results in decreased expression of CCN2 mRNA
sulindac sulfide results in increased expression of CCN2 mRNA
CTD PMID:12734198 PMID:16184548 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of CCND1 protein]
sulindac sulfide results in decreased expression of CCND1 mRNA; sulindac sulfide results in decreased expression of CCND1 protein
CTD PMID:14710233 PMID:15188006 PMID:15767558 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd4 Cd4 molecule increases expression ISO sulindac sulfide results in increased expression of CD4 mRNA CTD PMID:12734198 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Cd46 CD46 molecule decreases expression ISO sulindac sulfide results in decreased expression of CD46 mRNA CTD PMID:16184548 NCBI chr13:106,575,586...106,606,325 JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO sulindac sulfide results in increased expression of and results in increased activity of CDH1 protein CTD PMID:12391285 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh17 cadherin 17 decreases expression ISO sulindac sulfide results in decreased expression of CDH17 mRNA CTD PMID:16184548 NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
affects activity
increases expression
ISO PPARD protein inhibits the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; PPARG protein promotes the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]
sulindac sulfide affects the activity of CDKN1A protein
sulindac sulfide results in increased expression of CDKN1A mRNA; sulindac sulfide results in increased expression of CDKN1A protein
CTD PMID:15694660 PMID:15767558 PMID:16091736 PMID:16184548 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO sulindac sulfide results in increased expression of CEBPB mRNA; sulindac sulfide results in increased expression of CEBPB protein CTD PMID:12734198 PMID:16184548 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO sulindac sulfide results in decreased expression of CFLAR protein CTD PMID:11912124 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Clp1 cleavage factor polyribonucleotide kinase subunit 1 decreases expression ISO sulindac sulfide results in decreased expression of CLP1 mRNA CTD PMID:12734198 NCBI chr 3:69,806,774...69,818,633
Ensembl chr 3:69,806,778...69,810,421
JBrowse link
G Cryab crystallin, alpha B increases expression ISO sulindac sulfide results in increased expression of CRYAB mRNA CTD PMID:16184548 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of CTNNB1 protein]; sulindac sulfide affects the localization of and results in decreased expression of CTNNB1 protein; sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of CCND1 protein]; sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of MET protein]; sulindac sulfide results in decreased expression of and results in decreased localization of CTNNB1 protein CTD PMID:14555707 PMID:14710233 PMID:15188006 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsc cathepsin C decreases expression ISO sulindac sulfide results in decreased expression of CTSC mRNA CTD PMID:16184548 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Cyb5b cytochrome b5 type B decreases expression ISO sulindac sulfide results in decreased expression of CYB5B mRNA CTD PMID:12734198 NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO sulindac sulfide results in increased expression of CYP1A1 mRNA CTD PMID:12734198 PMID:16184548 PMID:17985343 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO sulindac sulfide results in increased expression of CYP1A2 mRNA CTD PMID:17985343 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO sulindac sulfide results in increased expression of CYP1B1 mRNA CTD PMID:12734198 PMID:17985343 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Dcbld2 discoidin, CUB and LCCL domain containing 2 increases expression ISO sulindac sulfide results in increased expression of DCBLD2 mRNA CTD PMID:12734198 NCBI chr11:42,125,787...42,179,927
Ensembl chr11:42,125,787...42,179,697
JBrowse link
G Ddx11 DEAD/H-box helicase 11 decreases expression ISO sulindac sulfide results in decreased expression of DDX11 mRNA CTD PMID:16184548 NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO sulindac sulfide results in decreased expression of DHCR24 mRNA CTD PMID:16184548 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO sulindac sulfide results in decreased expression of DHCR7 mRNA CTD PMID:16184548 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link
G Dynll1 dynein light chain LC8-type 1 decreases expression ISO sulindac sulfide results in decreased expression of DYNLL1 mRNA CTD PMID:12734198 NCBI chr12:41,312,367...41,314,742
Ensembl chr12:41,312,367...41,314,741
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
increases ubiquitination
increases phosphorylation
decreases phosphorylation
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]
sulindac sulfide results in increased ubiquitination of EGFR protein
sulindac sulfide results in increased phosphorylation of EGFR protein
sulindac sulfide results in decreased phosphorylation of EGFR protein
CTD PMID:20332299 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO EGR1 protein affects the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of GDF15 mRNA]; ELK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]
sulindac sulfide results in increased expression of EGR1 mRNA; sulindac sulfide results in increased expression of EGR1 protein
CTD PMID:15509713 PMID:16079301 PMID:16227405 PMID:17599376 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; ELK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; sulindac sulfide results in increased phosphorylation of and affects the activity of ELK1 protein; U 0126 inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein] CTD PMID:17599376 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of ERBB2 protein] CTD PMID:20332299 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of ERBB3 protein] CTD PMID:20332299 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 affects cleavage ISO sulindac sulfide affects the cleavage of ERBB4 protein CTD PMID:12777371 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
JBrowse link
G Esd esterase D increases expression ISO sulindac sulfide results in increased expression of ESD mRNA CTD PMID:12734198 NCBI chr15:50,043,634...50,063,134
Ensembl chr15:50,043,632...50,063,144
JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO sulindac sulfide results in decreased expression of ESR1 mRNA; sulindac sulfide results in decreased expression of ESR1 protein CTD PMID:16740773 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression ISO sulindac sulfide results in decreased expression of ETFB mRNA CTD PMID:16184548 NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068
JBrowse link
G Etnppl ethanolamine-phosphate phospho-lyase increases expression ISO sulindac sulfide results in increased expression of ETNPPL mRNA CTD PMID:12734198 NCBI chr 2:219,173,048...219,194,646
Ensembl chr 2:219,172,978...219,192,212
JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [sulindac sulfide analog results in increased expression of FABP1 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP1 protein] CTD PMID:17602619 PMID:18665581 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [sulindac sulfide analog results in increased expression of FABP4 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP4 protein] CTD PMID:17602619 PMID:18665581 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fcgrt Fc fragment of IgG receptor and transporter decreases expression ISO sulindac sulfide results in decreased expression of FCGRT mRNA CTD PMID:16184548 NCBI chr 1:95,574,436...95,584,171
Ensembl chr 1:95,567,175...95,584,084
JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression ISO sulindac sulfide results in decreased expression of FDPS mRNA CTD PMID:16184548 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 decreases expression ISO sulindac sulfide results in decreased expression of FGFR4 mRNA CTD PMID:16184548 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing
increases metabolic processing
ISO FMO3 gene polymorphism affects the metabolism of sulindac sulfide
FMO3 protein results in increased metabolism of sulindac sulfide
CTD PMID:17142560 PMID:17559352 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Foxm1 forkhead box M1 decreases expression ISO sulindac sulfide results in decreased expression of FOXM1 mRNA CTD PMID:16184548 NCBI chr 4:161,639,561...161,652,012
Ensembl chr 4:161,638,816...161,650,684
JBrowse link
G Gal3st4 galactose-3-O-sulfotransferase 4 decreases expression ISO sulindac sulfide results in decreased expression of GAL3ST4 mRNA CTD PMID:16184548 NCBI chr12:17,267,963...17,276,951
Ensembl chr12:17,267,963...17,276,833
JBrowse link
G Gars glycyl-tRNA synthetase increases expression ISO sulindac sulfide results in increased expression of GARS1 mRNA CTD PMID:12734198 NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions
increases expression
ISO EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of GDF15 mRNA]
sulindac sulfide results in increased expression of GDF15 mRNA; sulindac sulfide results in increased expression of GDF15 protein
CTD PMID:11895857 PMID:11925476 PMID:12734198 PMID:15180942 PMID:15509713 More... NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gk glycerol kinase increases expression ISO sulindac sulfide results in increased expression of GK mRNA CTD PMID:16184548 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631
JBrowse link
G Glcci1 glucocorticoid induced 1 increases expression ISO sulindac sulfide results in increased expression of GLCCI1 mRNA CTD PMID:16184548 NCBI chr 4:36,307,956...36,635,614
Ensembl chr 4:36,307,903...36,635,612
JBrowse link
G Grn granulin precursor decreases expression ISO sulindac sulfide results in decreased expression of GRN mRNA CTD PMID:16184548 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775