Ncapd3 (non-SMC condensin II complex, subunit D3) - Rat Genome Database

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Gene: Ncapd3 (non-SMC condensin II complex, subunit D3) Rattus norvegicus
Analyze
Symbol: Ncapd3
Name: non-SMC condensin II complex, subunit D3
RGD ID: 1562176
Description: Predicted to enable methylated histone binding activity. Predicted to be involved in chromosome condensation and regulation of chromosome segregation. Predicted to act upstream of or within meiotic chromosome separation. Predicted to be located in condensed chromosome and nucleus. Predicted to be part of condensin complex and pericentric heterochromatin. Predicted to be active in condensed chromosome, centromeric region. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPD3 (non-SMC condensin II complex subunit D3); INTERACTS WITH acetamide; bisphenol A; fipronil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: condensin-2 complex subunit D3; LOC315508; similar to mKIAA0056 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8833,696,214 - 33,765,520 (+)NCBIGRCr8
mRatBN7.2825,437,067 - 25,506,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl825,437,123 - 25,506,373 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx829,479,085 - 29,548,335 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0827,773,383 - 27,842,622 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0825,653,378 - 25,722,633 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0828,075,629 - 28,145,024 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl828,075,551 - 28,144,741 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0828,095,360 - 28,164,189 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4826,631,707 - 26,695,041 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera826,924,962 - 26,993,734 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:14532007   PMID:19946888   PMID:20551165   PMID:20622854   PMID:21795393   PMID:27737959  


Genomics

Comparative Map Data
Ncapd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8833,696,214 - 33,765,520 (+)NCBIGRCr8
mRatBN7.2825,437,067 - 25,506,375 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl825,437,123 - 25,506,373 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx829,479,085 - 29,548,335 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0827,773,383 - 27,842,622 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0825,653,378 - 25,722,633 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0828,075,629 - 28,145,024 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl828,075,551 - 28,144,741 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0828,095,360 - 28,164,189 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4826,631,707 - 26,695,041 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera826,924,962 - 26,993,734 (+)NCBICelera
Cytogenetic Map8q13NCBI
NCAPD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811134,150,113 - 134,225,461 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11134,150,113 - 134,225,504 (-)EnsemblGRCh38hg38GRCh38
GRCh3711134,020,008 - 134,095,355 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611133,527,547 - 133,599,636 (-)NCBINCBI36Build 36hg18NCBI36
Celera11131,195,520 - 131,267,291 (-)NCBICelera
Cytogenetic Map11q25NCBI
HuRef11129,976,877 - 130,049,300 (-)NCBIHuRef
CHM1_111133,909,159 - 133,981,162 (-)NCBICHM1_1
T2T-CHM13v2.011134,192,253 - 134,267,300 (-)NCBIT2T-CHM13v2.0
Ncapd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39926,941,455 - 27,008,667 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl926,941,471 - 27,006,611 (+)EnsemblGRCm39 Ensembl
GRCm38927,030,165 - 27,096,522 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl927,030,175 - 27,095,315 (+)EnsemblGRCm38mm10GRCm38
MGSCv37926,837,760 - 26,902,900 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36926,779,621 - 26,844,761 (+)NCBIMGSCv36mm8
Celera924,288,351 - 24,353,321 (+)NCBICelera
Cytogenetic Map9A4NCBI
cM Map912.12NCBI
Ncapd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541234,963,854 - 35,035,111 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541234,967,464 - 35,035,103 (-)NCBIChiLan1.0ChiLan1.0
NCAPD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29134,878,752 - 134,950,183 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111135,978,096 - 136,049,551 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011129,005,365 - 129,078,581 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111132,865,349 - 132,935,590 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11132,865,349 - 132,935,590 (-)Ensemblpanpan1.1panPan2
NCAPD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.151,021,588 - 1,081,846 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl51,020,690 - 1,081,446 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha51,141,269 - 1,201,495 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.05977,570 - 1,037,816 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl5977,103 - 1,037,812 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.151,010,779 - 1,070,093 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.051,010,946 - 1,071,343 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.051,048,890 - 1,109,082 (+)NCBIUU_Cfam_GSD_1.0
Ncapd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947115,914,608 - 115,984,945 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366841,616,974 - 1,692,235 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366841,618,271 - 1,687,905 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCAPD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl960,712,421 - 60,785,901 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1960,712,416 - 60,785,907 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2967,285,157 - 67,292,553 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCAPD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11125,212,744 - 125,285,488 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1125,210,486 - 125,284,920 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666043759,096 - 832,450 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ncapd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248128,709,735 - 8,782,200 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248128,708,061 - 8,782,282 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ncapd3
295 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:44
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000012078
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat

Markers in Region
MARC_14515-14516:1008860201:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2825,493,246 - 25,494,010 (+)MAPPERmRatBN7.2
Rnor_6.0828,131,896 - 28,132,659NCBIRnor6.0
Rnor_5.0828,151,061 - 28,151,824UniSTSRnor5.0
RGSC_v3.4826,681,913 - 26,682,676UniSTSRGSC3.4
Celera826,980,755 - 26,981,518UniSTS
Cytogenetic Map8q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 26 27 18 17 18 57 21 33 2
Low 2 17 30 23 2 23 8 11 17 14 8 9 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000012078   ⟹   ENSRNOP00000012078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl825,437,123 - 25,506,373 (+)Ensembl
Rnor_6.0 Ensembl828,075,551 - 28,144,741 (+)Ensembl
RefSeq Acc Id: NM_001034000   ⟹   NP_001029172
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8833,696,270 - 33,765,520 (+)NCBI
mRatBN7.2825,437,123 - 25,506,375 (+)NCBI
Rnor_6.0828,075,652 - 28,145,024 (+)NCBI
Rnor_5.0828,095,360 - 28,164,189 (+)NCBI
RGSC_v3.4826,631,707 - 26,695,041 (+)RGD
Celera826,924,962 - 26,993,734 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242735   ⟹   XP_006242797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8833,696,269 - 33,765,520 (+)NCBI
mRatBN7.2825,437,156 - 25,506,375 (+)NCBI
Rnor_6.0828,075,641 - 28,145,024 (+)NCBI
Rnor_5.0828,095,360 - 28,164,189 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242736   ⟹   XP_006242798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8833,696,214 - 33,765,520 (+)NCBI
mRatBN7.2825,437,067 - 25,506,375 (+)NCBI
Rnor_6.0828,075,629 - 28,145,024 (+)NCBI
Rnor_5.0828,095,360 - 28,164,189 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081366   ⟹   XP_038937294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8833,696,317 - 33,750,835 (+)NCBI
mRatBN7.2825,437,199 - 25,489,835 (+)NCBI
RefSeq Acc Id: XM_063265375   ⟹   XP_063121445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8833,696,317 - 33,765,520 (+)NCBI
RefSeq Acc Id: NP_001029172   ⟸   NM_001034000
- UniProtKB: Q3T1H0 (UniProtKB/TrEMBL),   F1LMD2 (UniProtKB/TrEMBL),   A6JYD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242798   ⟸   XM_006242736
- Peptide Label: isoform X1
- UniProtKB: A0A140UHX3 (UniProtKB/TrEMBL),   A6JYD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242797   ⟸   XM_006242735
- Peptide Label: isoform X1
- UniProtKB: A0A140UHX3 (UniProtKB/TrEMBL),   A6JYD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012078   ⟸   ENSRNOT00000012078
RefSeq Acc Id: XP_038937294   ⟸   XM_039081366
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063121445   ⟸   XM_063265375
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A140UHX3-F1-model_v2 AlphaFold A0A140UHX3 1-1497 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695819
Promoter ID:EPDNEW_R6344
Type:initiation region
Name:Ncapd3_1
Description:non-SMC condensin II complex, subunit D3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0828,076,186 - 28,076,246EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562176 AgrOrtholog
BioCyc Gene G2FUF-31305 BioCyc
Ensembl Genes ENSRNOG00000008932 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012078 ENTREZGENE
  ENSRNOT00000012078.8 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7939116 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  CND1/NCAPD3 UniProtKB/TrEMBL
  Cnd1_C UniProtKB/TrEMBL
  Condns_HCP-6 UniProtKB/TrEMBL
KEGG Report rno:315508 UniProtKB/TrEMBL
MGC_CLONE MGC:124743 IMAGE-MGC_LOAD
NCBI Gene 315508 ENTREZGENE
PANTHER CONDENSIN-2 COMPLEX SUBUNIT D3 UniProtKB/TrEMBL
  PTHR14222 UniProtKB/TrEMBL
Pfam Cnd1 UniProtKB/TrEMBL
PhenoGen Ncapd3 PhenoGen
PIRSF Condns_HCP-6 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008932 RatGTEx
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A140UHX3 ENTREZGENE, UniProtKB/TrEMBL
  A6JYD9 ENTREZGENE, UniProtKB/TrEMBL
  F1LMD2 ENTREZGENE
  Q3T1H0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LMD2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Ncapd3  non-SMC condensin II complex, subunit D3  LOC315508  similar to mKIAA0056 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC315508  similar to mKIAA0056 protein      Symbol and Name status set to provisional 70820 PROVISIONAL