Ddx11 (DEAD/H-box helicase 11) - Rat Genome Database

Name: Ddx11
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Ddx11 (DEAD/H-box helicase 11) Rattus norvegicus

Analyze

Symbol:

Ddx11

Name:

DEAD/H-box helicase 11

RGD ID:

1306675

Description:

Predicted to have ATPase activity; chromatin binding activity; and nucleic acid binding activity. Predicted to be involved in several processes, including cellular response to bleomycin; chromosome organization; and positive regulation of nucleobase-containing compound metabolic process. Predicted to colocalize with Ctf18 RFC-like complex. Human ortholog(s) of this gene implicated in Warsaw breakage syndrome. Orthologous to human DDX11 (DEAD/H-box helicase 11); INTERACTS WITH amphetamine; C60 fullerene; doxorubicin.

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae); LOC316767; probable ATP-dependent DNA helicase DDX11; probable ATP-dependent RNA helicase DDX11

Orthologs:

Homo sapiens (human) : DDX11 (DEAD/H-box helicase 11) HGNC Alliance
Mus musculus (house mouse) : Ddx11 (DEAD/H box helicase 11) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddx11 (DEAD/H-box helicase 11)
Pan paniscus (bonobo/pygmy chimpanzee) : DDX11 (DEAD/H-box helicase 11)
Canis lupus familiaris (dog) : DDX11 (DEAD/H-box helicase 11)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddx11 (DEAD/H-box helicase 11)
Sus scrofa (pig) : DDX11 (DEAD/H-box helicase 11)
Chlorocebus sabaeus (African green monkey) : DDX11 (DEAD/H-box helicase 11)
Heterocephalus glaber (naked mole-rat) : Ddx11 (DEAD/H-box helicase 11)

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	9	114,113,642 - 114,133,908 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	114,111,580 - 114,132,492 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	113,624,011 - 113,649,000 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	105,004,683 - 105,029,456	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	9	105,109,790 - 105,239,631	NCBI
Cytogenetic Map	9	q37	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chromosome Breakage (ISO)

genetic disease (ISO)

microcephaly (ISO)

Warsaw breakage syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

3-isobutyl-1-methyl-7H-xanthine (ISO)

aflatoxin B1 (ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (ISO)

bortezomib (ISO)

butanal (ISO)

C60 fullerene (EXP)

calcitriol (ISO)

cobalt dichloride (ISO)

coumestrol (ISO)

dexamethasone (ISO)

dioxygen (ISO)

doxorubicin (EXP)

ethyl methanesulfonate (ISO)

fenvalerate (EXP)

indometacin (ISO)

lead(0) (ISO)

lead(2+) (ISO)

leflunomide (ISO)

malathion (ISO)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

paracetamol (ISO)

potassium dichromate (ISO)

quercetin (ISO)

sodium arsenate (ISO)

sulindac sulfide (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

trichostatin A (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to bleomycin (ISO)

cellular response to cisplatin (ISO)

cellular response to DNA damage stimulus (ISO)

cellular response to hydroxyurea (ISO)

DNA duplex unwinding (IBA,ISO)

establishment of sister chromatid cohesion (IBA)

G-quadruplex DNA unwinding (ISO)

negative regulation of protein binding (ISO)

nucleolar chromatin organization (ISO)

positive regulation of chromatin binding (ISO)

positive regulation of double-strand break repair (ISO)

positive regulation of endodeoxyribonuclease activity (ISO)

positive regulation of sister chromatid cohesion (ISO)

positive regulation of transcription of nucleolar large rRNA by RNA polymerase I (ISO)

replication fork processing (ISO)

sister chromatid cohesion (ISO)

Cellular Component

centrosome (IEA,ISO)

chromatin (ISO)

Ctf18 RFC-like complex (ISO)

fibrillar center (IEA,ISO)

midbody (ISO)

mitotic cohesin complex (ISO)

nucleolus (ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,ISO)

spindle pole (ISO)

Molecular Function

ATP binding (IEA)

chromatin binding (ISO)

DNA binding (ISO)

DNA helicase activity (IBA,ISO)

DNA replication origin binding (ISO)

DNA-dependent ATPase activity (ISO)

double-stranded DNA binding (ISO)

G-quadruplex DNA binding (ISO)

helicase activity (ISO)

protein binding (ISO)

RNA-dependent ATPase activity (ISO)

single-stranded DNA binding (ISO)

single-stranded RNA binding (ISO)

triplex DNA binding (ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline
3.	RGD automated data pipeline
4.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9013641	PMID:10648783	PMID:16751776	PMID:17105772	PMID:17189189	PMID:18499658	PMID:18570454	PMID:20124417	PMID:23797032	PMID:26089203	PMID:26503245	PMID:27477908

Genomics

Comparative Map Data

Ddx11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	9	114,113,642 - 114,133,908 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	114,111,580 - 114,132,492 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	113,624,011 - 113,649,000 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	105,004,683 - 105,029,456	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	9	105,109,790 - 105,239,631	NCBI
Cytogenetic Map	9	q37	NCBI

DDX11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	12	31,073,860 - 31,104,799 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	12	31,073,860 - 31,104,799 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	12	31,226,779 - 31,257,733 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	31,118,046 - 31,148,992 (+)	NCBI	NCBI36		hg18	NCBI36
Cytogenetic Map	12	p11.21	NCBI
HuRef	12	30,992,012 - 31,022,870 (+)	NCBI		HuRef
CHM1_1	12	31,191,725 - 31,222,687 (+)	NCBI		CHM1_1

Ddx11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	66,430,508 - 66,459,169 (+)	NCBI
GRCm38	17	66,123,513 - 66,152,174 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	66,123,520 - 66,152,174 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	66,472,860 - 66,501,508 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	17	66,023,063 - 66,051,715 (+)	NCBI			mm8
Celera	17	70,431,796 - 70,460,387 (+)	NCBI		Celera
Cytogenetic Map	17	E1.1	NCBI

Ddx11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	1,932,729 - 1,957,231 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	1,932,988 - 1,957,231 (+)	NCBI	ChiLan1.0	ChiLan1.0

DDX11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Mhudiblu_PPA_v0	12	55,176,165 - 55,207,123 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

DDX11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	27	42,067,898 - 42,105,870 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	27	42,067,845 - 42,102,699 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Ddx11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936606	181,457 - 209,286 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DDX11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	67,321,132 - 67,397,111 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	67,359,399 - 67,395,739 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	69,616,368 - 69,630,616 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DDX11
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1 Ensembl	11	9,260,239 - 9,291,162 (+)	Ensembl
ChlSab1.1	11	9,260,206 - 9,290,308 (+)	NCBI

Ddx11
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624828	269,444 - 301,899 (-)	NCBI

Position Markers

RH133102

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	9	114,132,780 - 114,133,466	NCBI	Rnor6.0
Rnor_5.0	9	113,649,197 - 113,649,883	UniSTS	Rnor5.0
RGSC_v3.4	9	105,029,744 - 105,030,430	UniSTS	RGSC3.4
Cytogenetic Map	9	q37	UniSTS

RH143331

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	9	114,343,197 - 114,343,297	NCBI	Rnor6.0
Rnor_6.0	9	114,133,666 - 114,133,766	NCBI	Rnor6.0
Rnor_5.0	9	113,852,124 - 113,852,224	UniSTS	Rnor5.0
Rnor_5.0	9	113,650,083 - 113,650,183	UniSTS	Rnor5.0
RGSC_v3.4	9	105,030,630 - 105,030,730	UniSTS	RGSC3.4
RGSC_v3.4	9	105,321,046 - 105,321,146	UniSTS	RGSC3.4
Celera	9	103,342,411 - 103,342,511	UniSTS
Cytogenetic Map	9	q37	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	29075079	122095297	Rat
61385	Edpm9	Estrogen-dependent pituitary mass QTL 9	3.43	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	70241351	115241351	Rat
731171	Glom6	Glomerulus QTL 6	2.8	0.0003	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	9	70942881	115942881	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	81411073	119983851	Rat
7794784	Mcs31	Mammary carcinoma susceptibility QTL 31	2.98		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	9	90024661	119983851	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	35
Count of miRNA genes:	33
Interacting mature miRNAs:	35
Transcripts:	ENSRNOT00000016536
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	24	26	16	12	16			45	20	34	1
Low	2	19	31	25	7	25	8	10	29	15	7	10	8
Below cutoff								1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008767410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07068654	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AABR07068655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AABR07068656	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01102939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01102940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01102941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000079340 ⟹ ENSRNOP00000074629

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	9	114,111,580 - 114,132,492 (+)	Ensembl

RefSeq Acc Id:

XM_008767410 ⟹ XP_008765632

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	114,113,642 - 114,133,908 (+)	NCBI

Sequence:

show sequence

TTATCCCAAGTGTGCCGTGTGGAGACTGACCTCCATCTTGGTGTGTCTCCTAGGGCGGATGAGG
GTGAGGATGACTTGGAGGAAGAACATATAACCAAGATTTATTACTGCAGTCGGACACACTCACA
GCTGGCCCAGTTTGTGCGTGAGGTACAGAAGAGCCCTTTTGGCAAGGAGACGTGGCTAGTCTCC
CTTGGGTCTAGGCAGAGCCTTTGTGTGAATGAAGATGTGAAAAGCCTGGGTTCTGTGCACCTCA
TGAATGACCGCTGTGTGGACATGCAAAGACGCAAACACGAGAAGATGAGAATTGGGGAAGACAA
GCCAAAGAGAAGGAGACAGAAGATGCAGGCCTCCTGCCCCTTCTACAACCATGAGCAGATGGAG
CTTCTCCGGGATGAGATTCTGCTGGAGGTGAAGGACATGGAGCAGCTCGTGGCCCTCGGGAAGG
AGGCCCAGGCCTGCCCCTATTATGGAAGCCGCTTTGCCATCCCTGCAGCCCAGCTGGTGGTGCT
GCCCTACCCAATGCTGCTGCACGCAGCCACCCGGCAGGCTGCGGGAATCAGGCTGCAAGGGCAG
GTGGTCATTATTGACGAGGCTCACAACCTGATCGACACCATCACCAATATCCACAGCACAGAGG
TCAATGGTTCCCAGCTCTGCCAGGCCCATTCCCAGTTGCTCCAGTACATGGAAAGATACAGGAA
GCGTTTAAAGGCCAAGAACCTGATGTACATCAAGCAGATCCTGTACTTGCTGGACAAGTTTGTG
GCTGTTTTGGGAGGTAACGTTAAGCAAAACCCTAGTACACAGAGCCTGCCTCAGACAGGGTCTG
AGCTGCAGAGCATCAACGACTTTCTCTTTCAGAGCCAGGTGGACAACATCAACCTCTTCAAGGT
TCAGCGGTACCTGGAGAAGAGCATGCTCAGCAGGAAGCTCTTTGGCTTCACAGAATGCTTTGGA
GTTGTTCTTCCATCCCTCTCAGACTCTGAGGAGAACCGAGGTCTGGGTGGCTTCCAGCAGTTCC
TGAAGAGCCTGCAGTCAGGGCCTCCTGAGGACTCCCTGGAGGAGGGCCAGGCTGTAGCCCTGCG
GCCTGCCTCCCCACTGATGCACATTGAGGCCTTTTTAGAAGCTCTCACCACAGCCAACCAGGAT
GGCAGGGTGATCGTGAACCGCCAAGGCAGTGTTGGTCAGAGCAGCCTTAAGTTCTTACTCTTGA
ACCCAGCTGTGCACTTTGCCCAGGTGGTGAAGGAATGCCGAGCCCTGGTCATTGCTGGTGGCAC
CATGCAGCCGGTGTCTGACTTTCGGGAGCAGCTGCTGGCGTGTTCTGGGGTAGAAGCTTCGAGA
GTGGTTGAGTTCTCCTGTGGTCACGTGATCCCTCCAGACAACATCTTGCCCCTTATCATATGCA
GTGGGCCCTCTAACCAACAGCTGGAATTCACCTACCAGAGAAGAGAGCTGCCTCAGATGATGGA
GGAGACGGGCCGCATTCTCTGTAACTTGTGCAACGTGGTCCCTGGAGGGATGGTGTGCTTCCTT
CCTTCCTACGAGTACCTGCGCCAGGTACATGCTCACTGGGACAAGACTGGCCTGCTGGCACGTT
TGTCTGTCAGGAAAAAGATCTTTCAAGAGCCCAAGAGAGCGAGCCAGGTGGAGCAGGTGCTGAC
GGCGTATTCCACGTGCATTGCGAGCTGCAGTCACTCAGAAGGCCATCTGACAGGGGCCCTTCTC
CTCTCTGTGGTTGGAGGGAAGATGAGTGAAGGGATCAACTTCTCGGACGACCTGGGCCGGTGTG
TGGTGATGGTGGGGATGCCGTACCCCAACATTAAGTCTCCAGAGCTACAAGAGAAGATGGCCTA
CTTGGATCAGACCATTCCTAGGACACATGGTCAGCCCCCGCCAGGGACGGTATTGATAGAGAAT
CTGTGTATGAAGGCTATAAACCAATCCATAGGCAGGGCCATCAGGCACCAGAAGGACTTTGCCA
GCATTGTGCTCCTGGATCACCGGTATGCCCGGCCCTCCATCCTGGCCAAGTTGCCTGCCTGGAT
ACGAGACCGAGTGGAAGTCAAAGCCACCTTTGGGCCTGCTTTTGCTGCTATGCGGAAGTTCCAT
CGAGAAAAGTCACACCCATGTCTAGGGTAAGCTTGTGTTTATTTTCTGTGCTTGACCCGGCCTT
CGTATATGGCCTAAGAAGGTGCAAACCATATGCAGACTGCTGTGTGCACCAGCCTTCAGAGGCC
GTGCCCTCCAGTGTTTGGACTCACATAGAGAAGCCACAAGGACAGAGCCAGAACATCCTGAAGA
CACCACGTTCCCGGAGACAAGAGTCTCACTGTAGCACCTGGCTCAGGTTCAGCTCTCTGCCTTT
TCTGAGGTGAGGCCCGCCTGCCTCTGACCCACGCCATTTAAGCTTTCCTTGGCCTTGGACTCCC
ATCTCAGACACAGATGTCCTGTTTCAAGCTTTATTGCCTGGCCCAGAATTGTACACACATCATC
TGTCCAGAAGAGAATTTGAGAAAACAATGGGGACATACTTAATATTGAAAGAGCTGACATAAAC
TGATTTTTCTGAAGGACCCTTCACAAAGACTTGGACCCTGGTCATATACTTCTCTATACCCCAT
AAAGAAAGAAGCATTGATCCTATCCACAGCTCCTCAGGCCTCTGTGCTCAGAACAACGTTCCCC
TGTAAGACATGTCATGGGGCAAAAGGGTCTCCATGTTTTTCATTTTCTTCTGTTGTTCCCTGAA
CATGAACAGCTCCTTCATGTTCAGCAGTGGCTGTCCCTTATATGACCTTCGGGAAACTCAGGAG
CCATATGCCCTTGGCATTTAGGCAACACCCTGGGCTGCAAACTGAGAGGAGGCAAGAGGAGGCA
GAGGAGAGAGTGCAGGCTTGTCTTTCAATGGTGCTTGTACCGCTTGCAGCTCAAAGGGGTTCGA
TCCTTGAATCCTCCCCAGATTGAAGTGCCCTCACACCTGGGGGATGTTTTGAGACAGACAGACC
TTCACAGGGAGACACGTTAAGATTTTGTCACTAGCGCAGGACTTTAGCATGCACTGAAATGCAG
CTAGAAATCCAAGTTCTAAAAGGACCCAGAGAATGACAGCCTCTGTAAACCTTGAAGGATTGTC
ACTGGGAATCTACTCATCTGTTACCTGCTTTCTGAAATGGCAATGTTCCCAGGGTTATATCATA
GGAATATCATCCAGGTATCATGCCCAATTAAAACATTGATTGAATTTTGTGATCAAGTATGAGA
ATTTTCCTAAATGCAATTGATATCATGATAATAGATATTTGTCTAGAGACAGCGTGCAGTGTGA
GCTATGTAAAAGCATTGGGGAGATGCAGTGGGAGGAATAATTGATCCAGGTCATCAAAGGCGGC
AGCAGGCTGCAGAATGAAGAGACCCAGAGACCTCATTTGTTGTGTGACCTCCATCAAGCCACTT
AGAGACCTCCACACCTTAATGTGTTATTCACTTATTAAAATGTTTGTTCCATTTCCCTTATAAC
CTGAAATACATTGTCAAGCTCAAATCATTGAAAACTTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_008765632	(Get FASTA)	NCBI Sequence Viewer
	XP_017443925	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_008765632 ⟸ XM_008767410

- Peptide Label:

isoform X1

- Sequence:

show sequence

MNDRCVDMQRRKHEKMRIGEDKPKRRRQKMQASCPFYNHEQMELLRDEILLEVKDMEQLVALGK
EAQACPYYGSRFAIPAAQLVVLPYPMLLHAATRQAAGIRLQGQVVIIDEAHNLIDTITNIHSTE
VNGSQLCQAHSQLLQYMERYRKRLKAKNLMYIKQILYLLDKFVAVLGGNVKQNPSTQSLPQTGS
ELQSINDFLFQSQVDNINLFKVQRYLEKSMLSRKLFGFTECFGVVLPSLSDSEENRGLGGFQQF
LKSLQSGPPEDSLEEGQAVALRPASPLMHIEAFLEALTTANQDGRVIVNRQGSVGQSSLKFLLL
NPAVHFAQVVKECRALVIAGGTMQPVSDFREQLLACSGVEASRVVEFSCGHVIPPDNILPLIIC
SGPSNQQLEFTYQRRELPQMMEETGRILCNLCNVVPGGMVCFLPSYEYLRQVHAHWDKTGLLAR
LSVRKKIFQEPKRASQVEQVLTAYSTCIASCSHSEGHLTGALLLSVVGGKMSEGINFSDDLGRC
VVMVGMPYPNIKSPELQEKMAYLDQTIPRTHGQPPPGTVLIENLCMKAINQSIGRAIRHQKDFA
SIVLLDHRYARPSILAKLPAWIRDRVEVKATFGPAFAAMRKFHREKSHPCLG

hide sequence

RefSeq Acc Id:

ENSRNOP00000074629 ⟸ ENSRNOT00000079340

Protein Domains

Helicase ATP-binding

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
9	114116845	114116846	G	A	snv	F344/NRrrc (MCW), M520/N (MCW), ACI/N (MCW), WN/N (MCW), GH/OmrMcwi (MCW), COP/CrCrl (MCW & UW), SR/JrHsd (MCW), FHH/EurMcwi (MCW), SBH/Ygl (MCW), FHL/EurMcwi (MCW), SBN/Ygl (MCW), ACI/EurMcwi (MCW), SS/JrHsdMcwi (MCW)
9	114118990	114118991	C	T	snv	CDS, CDR, SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), SBN/Ygl (MCW), FHL/EurMcwi (MCW), FHH/EurMcwi (MCW), GH/OmrMcwi (MCW), SR/JrHsd (RGD), ACI/EurMcwi (MCW), SHRSP/Gcrc (RGD), SBN/Ygl (RGD), MNS/Gib (RGD), MHS/Gib (RGD), ACI/EurMcwi (RGD), BBDP/Wor (RGD), F344/NCrl (RGD), LE/Stm (RGD), LEW/Crl (RGD), LEW/NCrlBR (RGD), LH/MavRrrc (RGD), LN/MavRrrc (RGD), LL/MavRrrc (RGD)
9	114119036	114119037	C	T	snv	WN/N (MCW), ACI/N (MCW), M520/N (MCW), Buf/N (MCW), F344/NRrrc (MCW)
9	114119038	114119039	G	A	snv	ACI/EurMcwi (MCW), GH/OmrMcwi (MCW), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), CDR, CDS, ACI/EurMcwi (RGD), BBDP/Wor (RGD), F344/NCrl (RGD), LE/Stm (RGD), LEW/Crl (RGD), LEW/NCrlBR (RGD), LH/MavRrrc (RGD), LN/MavRrrc (RGD), MHS/Gib (RGD), MNS/Gib (RGD), SBN/Ygl (RGD), SHRSP/Gcrc (RGD), SR/JrHsd (RGD)
9	114120312	114120313	G	T	snv	SBH/Ygl (RGD), SBH/Ygl (MCW)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306675	AgrOrtholog
Ensembl Genes	ENSRNOG00000051528	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000074629	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000079340	ENTREZGENE, UniProtKB/TrEMBL
InterPro	DDX11/DDX12	UniProtKB/TrEMBL
	DEAD_2	UniProtKB/TrEMBL
	DNA_helicase_DNA-repair_Rad3	UniProtKB/TrEMBL
	Helic_SF1/SF2_ATP-bd_DinG/Rad3	UniProtKB/TrEMBL
	Helicase-like_DEXD_c2	UniProtKB/TrEMBL
	Helicase_ATP-dep_c2	UniProtKB/TrEMBL
NCBI Gene	316767	ENTREZGENE
PANTHER	PTHR11472:SF41	UniProtKB/TrEMBL
Pfam	DEAD_2	UniProtKB/TrEMBL
	Helicase_C_2	UniProtKB/TrEMBL
PhenoGen	Ddx11	PhenoGen
PROSITE	HELICASE_ATP_BIND_2	UniProtKB/TrEMBL
SMART	DEXDc2	UniProtKB/TrEMBL
	HELICc2	UniProtKB/TrEMBL
TIGRFAMs	rad3	UniProtKB/TrEMBL
UniProt	A0A0G2K8J3_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-13	Ddx11	DEAD/H-box helicase 11	Ddx11	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-16	Ddx11	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	Ddx11	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-02	Ddx11	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	Ddx11	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Ddx11	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)	Ddx11_predicted	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Ddx11_predicted	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM