RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Toxemia
Accession: DOID:9008067
browse the term
Definition: A condition produced by the presence of toxins or other harmful substances in the BLOOD.
Synonyms: exact_synonym: Toxemias
primary_id: MESH:D014115 ; RDO:0006726
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Trem1
triggering receptor expressed on myeloid cells 1
ameliorates
ISO
RGD
PMID:17230441
RGD:126928125
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
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Abcb11
ATP binding cassette subfamily B member 11
IEP
RGD
PMID:9828229
RGD:1598596
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
IEP
mRNA:decreased expression:liver (rat)
RGD
PMID:26977098
RGD:11041000
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b
ATP-binding cassette, sub-family B member 1B
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20300455 PMID:9828229
RGD:1598596
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abcc2
ATP binding cassette subfamily C member 2
IEP
RGD
PMID:16572733
RGD:1598611
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc8
ATP binding cassette subfamily C member 8
IEP
RGD
PMID:17285300
RGD:2301914
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
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Ace
angiotensin I converting enzyme
IEP
associated with Hemorrhage;protein:decreased activity:plasma (rat)
RGD
PMID:3028670
RGD:8142370
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ache
acetylcholinesterase
ISO
RGD
PMID:17657467
RGD:5688055
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Actc1
actin, alpha, cardiac muscle 1
IEP
RGD
PMID:11680626
RGD:1598729
NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523
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Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
IEP
protein:increased expression:plasma, spleen
RGD
PMID:23025351
RGD:9681752
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
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Adipoq
adiponectin, C1Q and collagen domain containing
IEP
associated with Obesity
RGD
PMID:23838384
RGD:8695926
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Adipor2
adiponectin receptor 2
severity
IEP
associated with obesity;mRNA:decreased expression:liver (rat)
RGD
PMID:23838384
RGD:8695926
NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
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Adra2a
adrenoceptor alpha 2A
onset
IEP
mRNA:increased expression:spleen
RGD
PMID:20302880
RGD:6480487
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
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Agtr2
angiotensin II receptor, type 2
IEP
protein:decreased expression:kidney
RGD
PMID:16725227
RGD:6903849
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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Ahr
aryl hydrocarbon receptor
severity
ISO
RGD
PMID:24930766
RGD:39939032
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Akp3
alkaline phosphatase 3, intestine, not Mn requiring
ISO
RGD
PMID:23569246
RGD:14349049
NCBI chr 9:87,804,680...87,808,715
Ensembl chr 9:87,804,749...87,807,913
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Akt1
AKT serine/threonine kinase 1
IEP
RGD
PMID:22824368
RGD:38676479
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Aldoa
aldolase, fructose-bisphosphate A
IEP
RGD
PMID:16930621
RGD:1599054
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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Alox5
arachidonate 5-lipoxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15328337
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Apoa1
apolipoprotein A1
treatment
ISO IDA
RGD
PMID:18593575 PMID:23227448
RGD:7241573 , RGD:7241868
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Apob
apolipoprotein B
IEP
RGD
PMID:16719989
RGD:1599165
NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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Apoe
apolipoprotein E
ISO
rat model treated with human protein
RGD
PMID:9153287
RGD:6904216
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Asl
argininosuccinate lyase
IEP
RGD
PMID:10652239
RGD:1599265
NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
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Ass1
argininosuccinate synthase 1
IEP
RGD
PMID:10652239
RGD:1599265
NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
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Atf2
activating transcription factor 2
treatment
IEP IDA
protein:increased expression, increased activity:small intestine mucosa
RGD
PMID:21641970 PMID:24312512
RGD:5135029 , RGD:10047418
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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Atp5f1a
ATP synthase F1 subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16741687
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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Bax
BCL2 associated X, apoptosis regulator
IEP
mRNA:increased expression:diaphragm
RGD
PMID:23940949
RGD:10054120
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bche
butyrylcholinesterase
ISO
RGD
PMID:17657467
RGD:5688055
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Bcl2
BCL2, apoptosis regulator
IEP
mRNA:decreased expression:diaphragm
RGD
PMID:23940949
RGD:10054120
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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C5ar1
complement C5a receptor 1
IEP
mRNA:increased expression:lung
RGD
PMID:9272704
RGD:70679
NCBI chr 1:76,948,622...76,959,826
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Casp1
caspase 1
IMP
RGD
PMID:17384935
RGD:2315892
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
IEP
mRNA:increased expression:diaphragm
RGD
PMID:23940949
RGD:10054120
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
ISO
RGD
PMID:19168786
RGD:5684539
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp9
caspase 9
treatment
IEP
RGD
PMID:23214195
RGD:10400903
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cbs
cystathionine beta synthase
severity
ISO IEP
mRNA:increased expression:liver (rat) Protein:increased expression:spleen, lung (mouse)
RGD
PMID:24702258 PMID:27748832 PMID:16100527 PMID:27748832
RGD:40903035 , RGD:40903019 , RGD:40903049 , RGD:40903019
NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
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Ccl2
C-C motif chemokine ligand 2
IEP
protein:increased expression:plasma
RGD
PMID:19060786
RGD:2307004
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl5
C-C motif chemokine ligand 5
IEP
protein:increased expression:plasma
RGD
PMID:16215387
RGD:2307171
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccr1
C-C motif chemokine receptor 1
ISO
RGD
PMID:17016504
RGD:5688178
NCBI chr 8:123,556,286...123,561,841
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Cd14
CD14 molecule
IEP
protein:increased expression:liver, endothelial cell of sinusoid
RGD
PMID:12046090
RGD:724637
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cd40
CD40 molecule
ISO
protein:decreased nitrosylation:macrophage
RGD
PMID:20473113
RGD:5490974
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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Cebpb
CCAAT/enhancer binding protein beta
treatment
IEP ISO
RGD
PMID:15192048 PMID:14659593
RGD:1625687 , RGD:40903034
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Cps1
carbamoyl-phosphate synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16741687
NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
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Cs
citrate synthase
IEP
protein:increased expression:gastrocnemius
RGD
PMID:25674200
RGD:329337350
NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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Csf3
colony stimulating factor 3
treatment
ISO
RGD
PMID:9514298
RGD:11039535
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Cx3cl1
C-X3-C motif chemokine ligand 1
IEP
protein:increased expression:atrium endocardium
RGD
PMID:19282612
RGD:4891965
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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Cxcl1
C-X-C motif chemokine ligand 1
ISO
mRNA:increased expression:multiple organs
RGD
PMID:9766630
RGD:5135254
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl2
C-X-C motif chemokine ligand 2
ISO
mRNA:increased expression:multiple organs
RGD
PMID:9766630
RGD:5135254
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cxcl6
C-X-C motif chemokine ligand 6
ISO
mRNA:increased expression:multiple organs
RGD
PMID:9766630
RGD:5135254
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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Edn1
endothelin 1
IEP
mRNA, protein:increased expression:liver (rat)
RGD
PMID:11206318
RGD:8662297
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Ep300
E1A binding protein p300
IEP
associated with Kidney Reperfusion Injury; protein:altered localization:kidney (rat)
RGD
PMID:23936185
RGD:7257563
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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Ephx2
epoxide hydrolase 2
ISO
RGD
PMID:19154430
RGD:5688360
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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Epo
erythropoietin
treatment
ISO
RGD
PMID:23214195
RGD:10400903
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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F12
coagulation factor XII
IEP
RGD
PMID:11092686
RGD:7394782
NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
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F2
coagulation factor II, thrombin
severity treatment
IDA ISO IEP
associated with liver cirrhosis;protein:increased expression:plasma (human) protein:increased expression:blood plasma (human) associated with liver cirrhosis;protein:increased expression:blood plasma (human)
RGD
PMID:21396682 PMID:9863491 PMID:10887118 PMID:25396762 PMID:10604885 PMID:7615203 PMID:22227956 PMID:20519137 More...
RGD:5147765 , RGD:14401592 , RGD:40818427 , RGD:10449434 , RGD:40818436 , RGD:14974253 , RGD:6893482 , RGD:5147779
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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F3
coagulation factor III, tissue factor
treatment
ISO IDA
associated with Protein C Deficiency
RGD
PMID:20858853 PMID:21396682 PMID:8956768
RGD:11341685 , RGD:5147765 , RGD:11340208
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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F5
coagulation factor V
IEP
RGD
PMID:11092686
RGD:7394782
NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
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F7
coagulation factor VII
treatment
ISO IEP
RGD
PMID:16378835 PMID:11092686
RGD:11041650 , RGD:7394782
NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
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F8
coagulation factor VIII
IEP
RGD
PMID:11092686
RGD:7394782
NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857
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Fas
Fas cell surface death receptor
IEP
mRNA, protein:increased expression:spleen (rat)
RGD
PMID:20428798
RGD:8662930
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fga
fibrinogen alpha chain
treatment
IDA
RGD
PMID:19295478
RGD:11040925
NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
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Foxp3
forkhead box P3
IEP
protein:increased expression:intestinal mucosa
RGD
PMID:19998507
RGD:38455980
NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838
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Gch1
GTP cyclohydrolase 1
treatment
IEP
associated with liver cirrhosis mRNA:increased expression:lung
RGD
PMID:14647062 PMID:9388472 PMID:16845913
RGD:401700399 , RGD:329961576 , RGD:401793756
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
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Gfer
growth factor, augmenter of liver regeneration
IEP
RGD
PMID:23073658
RGD:9685733
NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869
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Ghr
growth hormone receptor
IEP
mRNA:decreased expression:liver
RGD
PMID:12654216 PMID:12217886
RGD:2307380 , RGD:625688
NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
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Gpt
glutamic--pyruvic transaminase
treatment
IEP
RGD
PMID:25514429
RGD:401717525
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gsr
glutathione-disulfide reductase
treatment
IEP
RGD
PMID:25469663
RGD:10401928
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Hmgb1
high mobility group box 1
IEP
protein:increased expression:heart, serum
RGD
PMID:18503231
RGD:10402065
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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Hmox1
heme oxygenase 1
treatment
IEP
RGD
PMID:21396999
RGD:10755715
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hsf1
heat shock transcription factor 1
treatment
IDA
RGD
PMID:25571843
RGD:10402404
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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Hspa9
heat shock protein family A (Hsp70) member 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16741687
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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Hspd1
heat shock protein family D (Hsp60) member 1
IEP ISO
mRNA, protein:increased expression:medulla oblongata CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16741687 PMID:16675490
RGD:1624232
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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Icam1
intercellular adhesion molecule 1
IEP
protein:increased expression:lung (rat)
RGD
PMID:19776691
RGD:4145502
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ido1
indoleamine 2,3-dioxygenase 1
ISO
RGD
PMID:24930766 PMID:28077574
RGD:39939032 , RGD:39939117
NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
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Ido2
indoleamine 2,3-dioxygenase 2
ISO
RGD
PMID:24930766
RGD:39939032
NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324
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Ifng
interferon gamma
IEP
protein:increased expression:serum:
RGD
PMID:9195172
RGD:10755747
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Igf1
insulin-like growth factor 1
IEP
mRNA, protein:decreased expression:liver, serum
RGD
PMID:18492809 PMID:12217886
RGD:10402757 , RGD:625688
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Igfals
insulin-like growth factor binding protein, acid labile subunit
IEP
RGD
PMID:12217886
RGD:625688
NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677
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Igfbp1
insulin-like growth factor binding protein 1
IEP
RGD
PMID:12217886
RGD:625688
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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Igfbp3
insulin-like growth factor binding protein 3
IEP
mRNA, protein:decreased expression:liver, serum
RGD
PMID:18492809
RGD:10402757
NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
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Igfbp5
insulin-like growth factor binding protein 5
IEP
RGD
PMID:12217886
RGD:625688
NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
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Il10
interleukin 10
treatment
IEP ISO
protein:increased expression:plasma
RGD
PMID:19302852 PMID:27943364 PMID:28664613
RGD:2311055 , RGD:14975170 , RGD:14975137
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il13
interleukin 13
treatment
ISO
RGD
PMID:10674721
RGD:8549626
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il1a
interleukin 1 alpha
ISO IEP
protein:increased expression:plasma
RGD
PMID:9636192 PMID:22426124
RGD:6907109 , RGD:7794786
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
IEP
protein:increased expression:plasma
RGD
PMID:17201737
RGD:1626625
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
treatment
IEP ISO
mRNA:increased expression:lung, spleen, liver (rat)
RGD
PMID:1385928 PMID:8855299
RGD:8551846 , RGD:11522760
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il6
interleukin 6
IEP IDA
protein:increased expression:serum (rat) associated with Diabetes Mellitus, Experimental; Protein:increased expression:extracellular space (rat)
RGD
PMID:22227956 PMID:19449282 PMID:21396682
RGD:6893482 , RGD:2307179 , RGD:5147765
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Irak3
interleukin-1 receptor-associated kinase 3
ISO
mRNA, protein:increased expression:blood (human)
RGD
PMID:17982103
RGD:36049802
NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
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Irs1
insulin receptor substrate 1
ISO
protein:increased tyrosine nitration, decreased tyrosine phosphorylation:skeletal muscle
RGD
PMID:21206533
RGD:6483008
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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Itga2b
integrin subunit alpha 2b
IMP
RGD
PMID:15280099
RGD:2316360
NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
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Itgb3
integrin subunit beta 3
IMP
RGD
PMID:15280099
RGD:2316360
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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Keap1
Kelch-like ECH-associated protein 1
ISO
RGD
PMID:22609006
RGD:6892951
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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Lbp
lipopolysaccharide binding protein
treatment
ISO IEP
mRNA:increased expression:hepatocyte
RGD
PMID:16307218 PMID:8418776 PMID:8593028
RGD:9685193 , RGD:9685191 , RGD:9685196
NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
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Lcn2
lipocalin 2
ISO
mRNA:increased expression:brain,liver
RGD
PMID:21943033
RGD:126779582
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Map2
microtubule-associated protein 2
ISO
mRNA, protein:decreased expression:neuron
RGD
PMID:21421895
RGD:6483086
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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Mapk14
mitogen activated protein kinase 14
treatment
IEP IDA
protein:increased activity:small intestine mucosa
RGD
PMID:21641970 PMID:24312512
RGD:5135029 , RGD:10047418
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapk8
mitogen-activated protein kinase 8
IEP
protein:increased phophorylation:hippocampus (rat)
RGD
PMID:12207162
RGD:150340687
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mc4r
melanocortin 4 receptor
IEP
mRNA:increased expression:paraventricular nucleus (rat)
RGD
PMID:21343543
RGD:6484214
NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719
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Mif
macrophage migration inhibitory factor
IEP
protein:increased expression:plasma
RGD
PMID:16601957
RGD:1641983
NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
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Mir146a
microRNA 146a
treatment
ISO
miRNA:increased expression:spleen (mouse)
RGD
PMID:30867482
RGD:34888227
NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
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Mir155
microRNA 155
treatment
ISO
associated with familial hyperlipidemia
RGD
PMID:28264607 PMID:29979224 PMID:28970282 PMID:29079998
RGD:24922204 , RGD:21081538 , RGD:21079445 , RGD:21081539
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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Mme
membrane metallo-endopeptidase
severity
IMP
RGD
PMID:11078421
RGD:13801040
NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
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Mmp3
matrix metallopeptidase 3
IEP
RGD
PMID:17083784
RGD:2290426
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mt2A
metallothionein 2A
IEP
mRNA:increased expression:liver (rat)
RGD
PMID:22100509
RGD:6483852
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Mt3
metallothionein 3
IEP
RGD
PMID:12135776
RGD:10412330
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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Muc2
mucin 2, oligomeric mucus/gel-forming
IEP
RGD
PMID:19099858
RGD:7349370
NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756
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Myh6
myosin heavy chain 6
IEP
RGD
PMID:7874842
RGD:12792976
NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
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Myh7
myosin heavy chain 7
IEP
RGD
PMID:7874842
RGD:12792976
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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Nfe2l2
NFE2 like bZIP transcription factor 2
treatment
IEP
RGD
PMID:26646455
RGD:42722616
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkbia
NFKB inhibitor alpha
exacerbates treatment
ISO
RGD
PMID:19098124 PMID:10229101
RGD:126908017 , RGD:126928139
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos2
nitric oxide synthase 2
IEP IDA ISO
mRNA, protein:increased expression:intestine CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12620498 PMID:16787348 PMID:20519137
RGD:4891470 , RGD:5147779
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nos3
nitric oxide synthase 3
IEP
protein:increased expression:aorta (rat)
RGD
PMID:10462376
RGD:7794732
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Npy
neuropeptide Y
treatment
IDA
RGD
PMID:15342191
RGD:1580787
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
IDA
RGD
PMID:15640646
RGD:4892561
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Otc
ornithine transcarbamylase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16741687
NCBI chr X:12,453,834...12,529,954
Ensembl chr X:12,453,834...12,566,918
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Pck1
phosphoenolpyruvate carboxykinase 1
IEP
RGD
PMID:19268478 PMID:12217886
RGD:10427879 , RGD:625688
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
IEP
mRNA,protein:decreased expression,decreased activity:liver:
RGD
PMID:19268478
RGD:10427879
NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
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Pcsk1
proprotein convertase subtilisin/kexin type 1
IEP
RGD
PMID:16337011
RGD:6483567
NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434
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Pcsk2
proprotein convertase subtilisin/kexin type 2
IEP
RGD
PMID:16337011
RGD:6483567
NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
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Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
RGD
PMID:22119535
RGD:6771174
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Pf4
platelet factor 4
treatment
IEP
RGD
PMID:20601223
RGD:329901905
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
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Pgf
placental growth factor
ISO
protein:increased expression:multiple
RGD
PMID:16702604
RGD:6483601
NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
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Pla2g7
phospholipase A2 group VII
IEP
protein:increased expression: :
RGD
PMID:10748027
RGD:7248791
NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
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Plat
plasminogen activator, tissue type
treatment
ISO
RGD
PMID:9091588
RGD:11541073
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Pparg
peroxisome proliferator-activated receptor gamma
IEP
protein:increased expression:small intestine mucosa
RGD
PMID:21641970
RGD:5135029
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
ISO
mRNA:decreased expression:epididymal fat pad
RGD
PMID:20421294
RGD:6484543
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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Prkn
parkin RBR E3 ubiquitin protein ligase
ISO
protein:increased expression:liver, mitochondrion (mouse)
RGD
PMID:28615325
RGD:13432559
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
treatment
ISO
RGD
PMID:18205901 PMID:23170801
RGD:11100030 , RGD:11100034
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
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Ptafr
platelet-activating factor receptor
treatment
IMP
RGD
PMID:2178565
RGD:10041063
NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251
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Ptger4
prostaglandin E receptor 4
IEP
protein:increased expression:paraventricular hypothalamic nucleus parvicellular division (rat)
RGD
PMID:11058222
RGD:10043329
NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
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Ptgis
prostaglandin I2 synthase
treatment
IMP
RGD
PMID:11076704
RGD:401960076
NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
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Ptgs2
prostaglandin-endoperoxide synthase 2
IEP
RGD
PMID:21641970
RGD:5135029
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ren
renin
IEP ISO
protein:increased activity:blood plasma (rat) protein:increased activity:blood plasma (mouse)
RGD
PMID:16512638 PMID:30027346
RGD:125097499 , RGD:125097481
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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Serpinc1
serpin family C member 1
treatment
ISO IDA IEP
RGD
PMID:16457847 PMID:20519137 PMID:21396682 PMID:15995859
RGD:1599326 , RGD:5147779 , RGD:5147765 , RGD:1599332
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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Serpine1
serpin family E member 1
treatment
IEP IDA
RGD
PMID:21396682 PMID:25396762
RGD:5147765 , RGD:10449434
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Serpinf1
serpin family F member 1
ISO
protein:increased expression:plasma (human)
RGD
PMID:12386642
RGD:36174005
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
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Serping1
serpin family G member 1
treatment
ISO
RGD
PMID:18652771
RGD:8661643
NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
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Slc18a3
solute carrier family 18 member A3
IEP
protein:decreased expression:parietal cortex
RGD
PMID:17306796
RGD:5686693
NCBI chr16:7,713,630...7,716,491
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Slc22a1
solute carrier family 22 member 1
treatment
IDA
RGD
PMID:18313662
RGD:7243881
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc22a2
solute carrier family 22 member 2
treatment
IDA
RGD
PMID:18313662
RGD:7243881
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc38a3
solute carrier family 38, member 3
IEP
RGD
PMID:20036385
RGD:9999227
NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988
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Slc38a5
solute carrier family 38, member 5
IEP
RGD
PMID:20036385
RGD:9999227
NCBI chr X:14,213,727...14,222,498
Ensembl chr X:14,213,729...14,222,498
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Slc7a5
solute carrier family 7 member 5
IEP
RGD
PMID:26337286
RGD:151361133
NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
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Slpi
secretory leukocyte peptidase inhibitor
IEP
RGD
PMID:25466948
RGD:9999425
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Socs1
suppressor of cytokine signaling 1
ISO
mRNA:increased expression:liver, skeletal muscle
RGD
PMID:15169905
RGD:2298923
NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
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Socs3
suppressor of cytokine signaling 3
IEP ISO
mRNA:increased expression:liver, skeletal muscle
RGD
PMID:12217886 PMID:15169905
RGD:625688 , RGD:2298923
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16741687
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sparc
secreted protein acidic and cysteine rich
IEP
mRNA, protein:decreased expression:kidney
RGD
PMID:10703670
RGD:2300026
NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
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Stat5b
signal transducer and activator of transcription 5B
IDA
protein:decreased tyrosine phosphorylation:liver
RGD
PMID:17327369
RGD:1601383
NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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Tbxa2r
thromboxane A2 receptor
IMP IDA
RGD
PMID:2580129 PMID:15647606
RGD:11059531 , RGD:1601450
NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
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Tbxas1
thromboxane A synthase 1
IDA
RGD
PMID:15647606
RGD:1601450
NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
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Tdo2
tryptophan 2,3-dioxygenase
severity
ISO
RGD
PMID:24930766
RGD:39939032
NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
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Tfpi
tissue factor pathway inhibitor
treatment
ISO
RGD
PMID:17537762
RGD:11062086
NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
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Thbd
thrombomodulin
ISO IEP
mRNA:decreased expression:endothelial cell
RGD
PMID:19487933 PMID:20348393 PMID:12611420
RGD:5684988 , RGD:5685037 , RGD:1601652
NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
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Timp3
TIMP metallopeptidase inhibitor 3
IEP
RGD
PMID:17083784
RGD:2290426
NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
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Tlr2
toll-like receptor 2
treatment
IDA
RGD
PMID:22172266
RGD:7241094
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
disease_progression treatment
ISO IDA
mRNA:increased expression:liver:
RGD
PMID:23977376 PMID:23977376 PMID:22172266
RGD:14697731 , RGD:14697731 , RGD:7241094
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tnf
tumor necrosis factor
treatment
IEP IDA ISO
protein:increased expression:plasma protein:increased expression:plasma (rat) XCO:0000822 JTE-607 associated with liver cirrhosis
RGD
PMID:17324147 PMID:21396682 PMID:20519137 PMID:12813371 PMID:8283134 PMID:18078960 PMID:10493164 PMID:15242491 More...
RGD:4891465 , RGD:5147765 , RGD:5147779 , RGD:14995427 , RGD:14995443 , RGD:15023464 , RGD:40903016 , RGD:38501090
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Trem1
triggering receptor expressed on myeloid cells 1
treatment
ISO
RGD
PMID:21507332 PMID:15585833
RGD:126925982 , RGD:126928122
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
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Vcam1
vascular cell adhesion molecule 1
IEP
mRNA:increased expression:brain:
RGD
PMID:20061033
RGD:7240511
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vwf
von Willebrand factor
IEP
protein:increased expression:endothelial cell:
RGD
PMID:2650559
RGD:11079230
NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
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Gch1
GTP cyclohydrolase 1
treatment
IDA
RGD
PMID:8602831
RGD:329961578
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
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Htr2a
5-hydroxytryptamine receptor 2A
treatment
IMP
RGD
PMID:19318092
RGD:401901206
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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