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Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice.

Authors: Hirsch, E  Irikura, VM  Paul, SM  Hirsh, D 
Citation: Hirsch E, etal., Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11008-13.
Pubmed: (View Article at PubMed) PMID:8855299

Interleukin 1 receptor antagonist (IL-1ra) is a cytokine whose only known action is competitive inhibition of the binding of interleukin 1 (IL-1) to its receptor. To investigate the physiological roles of endogenously produced IL-1ra, we generated mice that either lack IL-1ra or overproduce it under control of the endogenous promoter. Mice lacking IL-1ra have decreased body mass compared with wild-type controls. They are more susceptible than controls to lethal endotoxemia but are less susceptible to infection with Listeria monocytogenes. Conversely, IL-1ra overproducers are protected from the lethal effects of endotoxin but are more susceptible to listeriosis. Serum levels of IL-1 following an endotoxin challenge are decreased in IL-1ra nulls and increased in IL-1ra overproducers in comparison to controls. These data demonstrate critical roles for endogenously produced IL-1ra in growth, responses to infection and inflammation, and regulation of cytokine expression.


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RGD Object Information
RGD ID: 11522760
Created: 2016-08-08
Species: All species
Last Modified: 2016-08-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.