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Hypertension associated with reduced plasma thrombomodulin levels and a hypercoagulable state in rats.

Authors: Sawada, K  Naiki, M  Yago, H  Matsushita, K  Ohtsuki, T  Kitagawa, K  Matsumoto, M  Hori, M 
Citation: Sawada K, etal., Clin Exp Hypertens. 2003 Feb;25(2):73-84.
Pubmed: (View Article at PubMed) PMID:12611420

The plasma thrombomodulin (TM) level, an indicator of systemic endothelial cell damage, was measured in spontaneously hypertensive rats (SHR), deoxycorticosteron acetate (DOCA)-induced hypertensive rats and normotensive Wistar-Kyoto (WKY) rats to clarify its changes in hypertension. Plasma TM levels, measured by enzyme-linked immuno-sorbent assay, decreased with aging (5-20-weeks-old) in both SHR and WKY, and they were lower in SHR than age-matched WKY in all ages examined. Deoxycorticosteron acetate-induced hypertensive WKY also showed decreased TM levels compared with normotensive WKY. Accelerated coagulation and fibrinolysis shown by the increases in thrombin-antithrombin complex (TAT) and D-dimer levels were observed in both groups of hypertensive rats. These results suggest that hypertension may decrease plasma TM levels and induce a hypercoagulable state in rats.


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RGD Object Information
RGD ID: 1601652
Created: 2007-04-27
Species: All species
Last Modified: 2007-04-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.