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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:endotoxin shock
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Accession:DOID:9007601 term browser browse the term
Definition:When endotoxemia, a condition characterized by the presence of endotoxins (bacterial lipopolysacharrides) in the blood is accompanied by hypotension despite adequate fluid infusion, it is called endotoxin shock. On lysis of, or secretion by gram-negative bacteria, bacterial lipopolysacharride (LPS) enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
Synonyms:exact_synonym: endotoxic shock
 broad_synonym: septic shock
 xref: EFO:0006834


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endotoxin shock term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gch1 GTP cyclohydrolase 1 treatment IDA RGD PMID:8602831 RGD:329961578 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A treatment IMP RGD PMID:19318092 RGD:401901206 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    disease by infectious agent 2211
      Bacterial Infections and Mycoses 1072
        Toxemia 178
          Endotoxemia 160
            endotoxin shock 2
Path 2
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18211
      Immune & Inflammatory Diseases 5566
        Inflammation 2763
          Systemic Inflammatory Response Syndrome 396
            Sepsis 394
              bacterial sepsis 175
                Bacteremia 175
                  Endotoxemia 160
                    endotoxin shock 2
paths to the root