RGD Reference Report - Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia. - Rat Genome Database

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Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia.

Authors: Knapp, Sylvia  Gibot, Sébastien  de Vos, Alex  Versteeg, Henri H  Colonna, Marco  van der Poll, Tom 
Citation: Knapp S, etal., J Immunol. 2004 Dec 15;173(12):7131-4. doi: 10.4049/jimmunol.173.12.7131.
RGD ID: 126928122
Pubmed: PMID:15585833   (View Abstract at PubMed)
DOI: DOI:10.4049/jimmunol.173.12.7131   (Journal Full-text)

Triggering receptor expressed on myeloid cells-1 (TREM-1) is a recently identified molecule involved in the amplification of inflammation. To determine the regulation of TREM-1, we studied TREM-1 expression and soluble TREM-1 plasma levels upon i.v. LPS challenge in healthy humans in vivo and in vitro. Granulocyte TREM-1 expression was high at baseline and immediately down-regulated upon LPS exposure along with an increase in soluble TREM-1. Monocytes displayed a gradual up-regulation of TREM-1 upon LPS in vivo and in vitro. In vitro studies extended these findings to highly purified lipoteichoic acid and Streptococcus pneumoniae. Nonbacterial TLR ligands such as polyinosine-polycytidylic acid and imidazoquinoline, as well as the TLR9 ligand CpG, did not impact TREM-1 expression. The LPS-induced alterations in TREM-1 surface expression were not a result of increased TNF-alpha or IL-10. Inhibitor studies disclosed a PI3K-dependent pathway in LPS-induced up-regulation of TREM-1 on monocytes, whereas MAPK played a limited role.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TREM1HumanEndotoxemia  IEP  RGD 
Trem1RatEndotoxemia  ISOTREM1 (Homo sapiens) RGD 
Trem1MouseEndotoxemia  ISOTREM1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Trem1  (triggering receptor expressed on myeloid cells 1)

Genes (Mus musculus)
Trem1  (triggering receptor expressed on myeloid cells 1)

Genes (Homo sapiens)
TREM1  (triggering receptor expressed on myeloid cells 1)


Additional Information