TREM1 (triggering receptor expressed on myeloid cells 1) - Rat Genome Database

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Gene: TREM1 (triggering receptor expressed on myeloid cells 1) Homo sapiens
Analyze
Symbol: TREM1
Name: triggering receptor expressed on myeloid cells 1
RGD ID: 1319823
HGNC Page HGNC
Description: Enables scaffold protein binding activity. Predicted to be involved in neutrophil chemotaxis and neutrophil-mediated killing of gram-negative bacterium. Predicted to act upstream of or within neutrophil extravasation. Predicted to be located in plasma membrane. Implicated in bacterial sepsis and malaria. Biomarker of several diseases, including bacterial gastritis; chorioamnionitis; hepatitis B; hepatitis C; and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD354; TREM-1; triggering receptor expressed on monocytes 1; triggering-receptor TREM1
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl641,267,926 - 41,286,682 (-)EnsemblGRCh38hg38GRCh38
GRCh38641,267,385 - 41,286,692 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37641,235,123 - 41,254,420 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,351,690 - 41,362,435 (-)NCBINCBI36hg18NCBI36
Build 34641,351,689 - 41,362,435NCBI
Celera642,797,142 - 42,807,885 (-)NCBI
Cytogenetic Map6p21.1NCBI
HuRef640,961,518 - 40,972,978 (-)NCBIHuRef
CHM1_1641,246,251 - 41,257,709 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
1. Adukpo S, etal., Trop Med Int Health. 2016 Dec;21(12):1592-1601. doi: 10.1111/tmi.12787. Epub 2016 Oct 24.
2. Boufenzer A, etal., Circ Res. 2015 May 22;116(11):1772-82. doi: 10.1161/CIRCRESAHA.116.305628. Epub 2015 Apr 3.
3. Buckland KF, etal., Immunol Invest. 2011;40(7-8):692-722. doi: 10.3109/08820139.2011.578270. Epub 2011 May 19.
4. Cheng PC, etal., Parasite Immunol. 2011 May;33(5):276-86. doi: 10.1111/j.1365-3024.2011.01284.x.
5. Determann RM, etal., Intensive Care Med. 2006 Aug;32(8):1243-7. doi: 10.1007/s00134-006-0240-4. Epub 2006 Jun 20.
6. Fan D, etal., Int J Mol Sci. 2016 Apr 2;17(4):498. doi: 10.3390/ijms17040498.
7. Fang K, etal., Front Pharmacol. 2020 Jan 17;10:1544. doi: 10.3389/fphar.2019.01544. eCollection 2019.
8. Feng JY, etal., Sci Rep. 2018 May 29;8(1):8223. doi: 10.1038/s41598-018-26478-2.
9. Gibot S, etal., Crit Care Med. 2008 Feb;36(2):504-10. doi: 10.1097/01.CCM.0B013E318161FAF3.
10. Gibot S, etal., Eur J Immunol. 2007 Feb;37(2):456-66. doi: 10.1002/eji.200636387.
11. Gibot S, etal., J Infect Dis. 2006 Oct 1;194(7):975-83. doi: 10.1086/506950. Epub 2006 Aug 29.
12. Gibot S, etal., Shock. 2009 Dec;32(6):633-7. doi: 10.1097/SHK.0b013e3181a53842.
13. GOA_HUMAN data from the GO Consortium
14. Gorlier C, etal., Innate Immun. 2019 Nov;25(8):487-490. doi: 10.1177/1753425919870847. Epub 2019 Aug 31.
15. Hommes TJ, etal., J Pathol. 2014 Aug;233(4):357-67. doi: 10.1002/path.4361. Epub 2014 Jun 3.
16. Hyun J, etal., PLoS Pathog. 2019 Jul 1;15(7):e1007883. doi: 10.1371/journal.ppat.1007883. eCollection 2019 Jul.
17. Jiang WL, etal., Phytother Res. 2012 Jul;26(7):981-7. doi: 10.1002/ptr.3668. Epub 2011 Dec 6.
18. Kamei K, etal., J Hepatobiliary Pancreat Sci. 2010 May;17(3):305-12. doi: 10.1007/s00534-009-0191-6. Epub 2009 Sep 29.
19. Knapp S, etal., J Immunol. 2004 Dec 15;173(12):7131-4. doi: 10.4049/jimmunol.173.12.7131.
20. Kozik JH, etal., Sci Rep. 2016 Jun 22;6:28556. doi: 10.1038/srep28556.
21. Kusanovic JP, etal., J Matern Fetal Neonatal Med. 2010 Jan;23(1):34-47. doi: 10.3109/14767050903009248.
22. Lagler H, etal., J Immunol. 2009 Aug 1;183(3):2027-36. doi: 10.4049/jimmunol.0803862. Epub 2009 Jul 13.
23. Liang YB, etal., Biochem Biophys Res Commun. 2020 Aug 27;529(3):554-561. doi: 10.1016/j.bbrc.2020.05.056. Epub 2020 Jul 15.
24. Lin YT, etal., Infect Immun. 2014 Mar;82(3):1335-42. doi: 10.1128/IAI.01347-13. Epub 2014 Jan 6.
25. Liu M, etal., Biol Pharm Bull. 2015;38(10):1450-7. doi: 10.1248/bpb.b15-00057. Epub 2015 Aug 5.
26. Luo L, etal., Chin Med J (Engl). 2010 Jun;123(12):1561-5.
27. RGD automated import pipeline for gene-chemical interactions
28. Schmausser B, etal., Clin Exp Immunol. 2008 Apr;152(1):88-94. doi: 10.1111/j.1365-2249.2008.03608.x.
29. Su L, etal., BMC Infect Dis. 2012 Jul 18;12:157. doi: 10.1186/1471-2334-12-157.
30. Sun XG, etal., Exp Neurol. 2021 Jul;341:113692. doi: 10.1016/j.expneurol.2021.113692. Epub 2021 Mar 13.
31. Sun XG, etal., Neuroscience. 2019 May 15;406:369-375. doi: 10.1016/j.neuroscience.2019.03.032. Epub 2019 Mar 23.
32. Thankam FG, etal., Sci Rep. 2018 Jun 11;8(1):8918. doi: 10.1038/s41598-018-27250-2.
33. Tong J, etal., Immunol Lett. 2011 Aug 30;138(2):137-43. doi: 10.1016/j.imlet.2011.04.001. Epub 2011 Apr 9.
34. Ubagai T, etal., Int J Med Sci. 2014 Jan 10;11(2):215-21. doi: 10.7150/ijms.7231. eCollection 2014.
35. Ubagai T, etal., Jpn J Infect Dis. 2012;65(5):376-82. doi: 10.7883/yoken.65.376.
36. Weber B, etal., PLoS Pathog. 2014 Jan;10(1):e1003900. doi: 10.1371/journal.ppat.1003900. Epub 2014 Jan 16.
37. Wei M, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015 Sep;33(9):646-51.
38. Wiersinga WJ, etal., J Infect Dis. 2007 Dec 1;196(11):1707-16. doi: 10.1086/522141. Epub 2007 Oct 25.
39. Wu WC, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 2018 Mar 9;53(3):157-163. doi: 10.3760/cma.j.issn.1002-0098.2018.03.003.
40. Yao L, etal., Mol Med Rep. 2021 Mar;23(3). pii: 219. doi: 10.3892/mmr.2021.11858. Epub 2021 Jan 26.
41. Zhang X, etal., J Cell Physiol. 2019 May;234(5):6917-6926. doi: 10.1002/jcp.27450. Epub 2018 Nov 27.
42. Zhao Y, etal., Mol Cell Endocrinol. 2018 Sep 15;473:44-52. doi: 10.1016/j.mce.2018.01.001. Epub 2018 Jan 10.
43. Zhong J, etal., PLoS One. 2016 Mar 10;11(3):e0150114. doi: 10.1371/journal.pone.0150114. eCollection 2016.
44. Zhou X, etal., Mol Med Rep. 2017 Apr;15(4):1565-1570. doi: 10.3892/mmr.2017.6167. Epub 2017 Feb 6.
45. Zhu H, etal., Microb Biotechnol. 2019 Nov;12(6):1337-1345. doi: 10.1111/1751-7915.13467. Epub 2019 Jul 31.
Additional References at PubMed
PMID:8125298   PMID:10799849   PMID:11323674   PMID:11602640   PMID:11922939   PMID:12477932   PMID:12645956   PMID:12646648   PMID:12792857   PMID:14574404   PMID:14656437   PMID:15067076  
PMID:15309732   PMID:15351648   PMID:15489334   PMID:16344560   PMID:16437719   PMID:16733861   PMID:17008237   PMID:17202378   PMID:17277102   PMID:17336301   PMID:17452516   PMID:17505044  
PMID:17558349   PMID:17634956   PMID:17659879   PMID:17729416   PMID:17785845   PMID:18317529   PMID:18396215   PMID:18628981   PMID:18634145   PMID:18656898   PMID:18818748   PMID:19019335  
PMID:19109693   PMID:19230638   PMID:19251433   PMID:19396532   PMID:19479878   PMID:19484952   PMID:19527514   PMID:19913121   PMID:19917159   PMID:19923060   PMID:20140262   PMID:20156945  
PMID:20237496   PMID:20375613   PMID:20628086   PMID:20640189   PMID:21148811   PMID:21306476   PMID:21393102   PMID:21421043   PMID:21555403   PMID:21701149   PMID:21763322   PMID:21855288  
PMID:21873635   PMID:21910175   PMID:21942576   PMID:21967868   PMID:21976106   PMID:22020285   PMID:22179409   PMID:22417086   PMID:22422501   PMID:22459945   PMID:22642593   PMID:22721842  
PMID:22798017   PMID:22829716   PMID:23046618   PMID:23364598   PMID:23383108   PMID:23414215   PMID:23436478   PMID:23468854   PMID:23571837   PMID:23734253   PMID:23861562   PMID:23880194  
PMID:24012914   PMID:24012964   PMID:24026310   PMID:24261769   PMID:24281714   PMID:24289157   PMID:24290866   PMID:24447863   PMID:24605677   PMID:24661408   PMID:24672147   PMID:24702227  
PMID:24842612   PMID:24924298   PMID:24954324   PMID:25128583   PMID:25213166   PMID:25242387   PMID:25294884   PMID:25319790   PMID:25448705   PMID:25461656   PMID:25465376   PMID:25532536  
PMID:25545807   PMID:25595774   PMID:25642940   PMID:25944130   PMID:26184544   PMID:26281323   PMID:26320130   PMID:26384438   PMID:26397033   PMID:26495896   PMID:26506490   PMID:26852644  
PMID:26877157   PMID:27017522   PMID:27096761   PMID:27238916   PMID:27244892   PMID:27319606   PMID:27324541   PMID:27409178   PMID:27448788   PMID:27521929   PMID:27542376   PMID:27631216  
PMID:27648678   PMID:27670763   PMID:27697433   PMID:27729010   PMID:27743451   PMID:27762264   PMID:27792788   PMID:27846213   PMID:27862781   PMID:27917624   PMID:27928159   PMID:27932245  
PMID:28089248   PMID:28111922   PMID:28181540   PMID:28367708   PMID:28380382   PMID:28771614   PMID:28791839   PMID:28837205   PMID:28920169   PMID:29080545   PMID:29093489   PMID:29333781  
PMID:29338161   PMID:29480083   PMID:29516326   PMID:29534643   PMID:29644420   PMID:29886421   PMID:29961347   PMID:30010135   PMID:30137027   PMID:30257363   PMID:30420902   PMID:30465338  
PMID:30616644   PMID:30637597   PMID:30685385   PMID:30810243   PMID:30918427   PMID:31287012   PMID:31444693   PMID:31509552   PMID:31546668   PMID:31594258   PMID:31680426   PMID:31721052  
PMID:31885496   PMID:32027618   PMID:32123257   PMID:32255294   PMID:32326783   PMID:32356439   PMID:32508526   PMID:32508528   PMID:32513696   PMID:32571463   PMID:32655314   PMID:32684831  
PMID:32908142   PMID:33204302   PMID:33297569   PMID:33316373   PMID:34002612   PMID:34195785  


Genomics

Comparative Map Data
TREM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl641,267,926 - 41,286,682 (-)EnsemblGRCh38hg38GRCh38
GRCh38641,267,385 - 41,286,692 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37641,235,123 - 41,254,420 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,351,690 - 41,362,435 (-)NCBINCBI36hg18NCBI36
Build 34641,351,689 - 41,362,435NCBI
Celera642,797,142 - 42,807,885 (-)NCBI
Cytogenetic Map6p21.1NCBI
HuRef640,961,518 - 40,972,978 (-)NCBIHuRef
CHM1_1641,246,251 - 41,257,709 (-)NCBICHM1_1
Trem1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,539,763 - 48,553,955 (+)NCBIGRCm39mm39
GRCm39 Ensembl1748,539,796 - 48,553,952 (+)Ensembl
GRCm381748,232,713 - 48,246,927 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,232,768 - 48,246,924 (+)EnsemblGRCm38mm10GRCm38
MGSCv371748,371,922 - 48,386,091 (+)NCBIGRCm37mm9NCBIm37
MGSCv361747,698,178 - 47,712,333 (+)NCBImm8
Celera1751,668,001 - 51,682,161 (+)NCBICelera
Cytogenetic Map17CNCBI
Trem1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2912,763,819 - 12,779,285 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl912,763,819 - 12,779,203 (-)Ensembl
Rnor_6.0914,727,887 - 14,743,371 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,727,976 - 14,809,447 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0913,649,246 - 13,664,645 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,175,081 - 8,186,142 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.198,175,083 - 8,193,441 (-)NCBI
Celera910,535,490 - 10,546,547 (-)NCBICelera
Cytogenetic Map9q12NCBI
TREM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1642,168,992 - 42,182,134 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,163,337 - 42,183,091 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0640,861,283 - 40,874,446 (-)NCBIMhudiblu_PPA_v0panPan3
TREM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1129,990,678 - 10,000,195 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl129,990,679 - 10,000,236 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1210,020,952 - 10,030,132 (-)NCBI
ROS_Cfam_1.01210,470,281 - 10,479,802 (-)NCBI
UMICH_Zoey_3.11210,002,655 - 10,011,845 (-)NCBI
UNSW_CanFamBas_1.01210,084,374 - 10,093,559 (-)NCBI
UU_Cfam_GSD_1.01210,179,448 - 10,188,597 (-)NCBI
Trem1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,374,752 - 45,385,967 (-)NCBI
SpeTri2.0NW_00493647618,577,825 - 18,583,675 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TREM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,510,253 - 36,531,796 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1736,510,253 - 36,531,796 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2741,804,122 - 41,825,672 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TREM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,873,647 - 30,885,292 (+)NCBI
ChlSab1.1 Ensembl1730,873,666 - 30,886,967 (+)Ensembl
Vero_WHO_p1.0NW_02366604441,275,669 - 41,288,974 (-)NCBI

Position Markers
RH121075  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37641,249,729 - 41,250,030UniSTSGRCh37
Build 36641,357,707 - 41,358,008RGDNCBI36
Celera642,803,158 - 42,803,459RGD
Cytogenetic Map6p21.1UniSTS
HuRef640,968,246 - 40,968,547UniSTS
TNG Radiation Hybrid Map622046.0UniSTS
RH48773  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37641,243,835 - 41,243,958UniSTSGRCh37
Build 36641,351,813 - 41,351,936RGDNCBI36
Celera642,797,265 - 42,797,388RGD
Cytogenetic Map6p21.1UniSTS
HuRef640,962,354 - 40,962,477UniSTS
GeneMap99-GB4 RH Map6154.48UniSTS
NCBI RH Map6633.7UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1712
Count of miRNA genes:863
Interacting mature miRNAs:993
Transcripts:ENST00000244709, ENST00000334475, ENST00000586287, ENST00000589614, ENST00000589695, ENST00000589882, ENST00000591620
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 13 822 32 6 852 5 31 8 32 7 37 616 1 55 21 1
Low 788 1508 848 258 522 185 1791 477 1155 183 478 554 79 1 1002 1166 4
Below cutoff 1487 642 803 320 408 236 2203 1648 2290 173 838 326 89 147 1545 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001242589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001242590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_018643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_136332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006715117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011514696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011514697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF196329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF287008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL391903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW264786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX965596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY074783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI910026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA417244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS265711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA362458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA938757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC428714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ217941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF458151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000244709   ⟹   ENSP00000244709
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl641,273,605 - 41,286,682 (-)Ensembl
RefSeq Acc Id: ENST00000334475   ⟹   ENSP00000334284
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl641,275,621 - 41,286,682 (-)Ensembl
RefSeq Acc Id: ENST00000586287
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl641,282,254 - 41,286,682 (-)Ensembl
RefSeq Acc Id: ENST00000589614   ⟹   ENSP00000465688
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl641,267,926 - 41,286,665 (-)Ensembl
RefSeq Acc Id: ENST00000589695
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl641,275,986 - 41,281,234 (-)Ensembl
RefSeq Acc Id: ENST00000589882
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl641,280,191 - 41,282,066 (-)Ensembl
RefSeq Acc Id: ENST00000591620   ⟹   ENSP00000465345
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl641,279,539 - 41,286,682 (-)Ensembl
RefSeq Acc Id: NM_001242589   ⟹   NP_001229518
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,279,537 - 41,286,682 (-)NCBI
GRCh37641,242,999 - 41,254,457 (-)ENTREZGENE
HuRef640,961,518 - 40,972,978 (-)ENTREZGENE
CHM1_1641,250,529 - 41,257,735 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001242590   ⟹   NP_001229519
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,273,605 - 41,286,682 (-)NCBI
GRCh37641,242,999 - 41,254,457 (-)ENTREZGENE
HuRef640,961,518 - 40,972,978 (-)ENTREZGENE
CHM1_1641,244,595 - 41,257,735 (-)NCBI
Sequence:
RefSeq Acc Id: NM_018643   ⟹   NP_061113
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,273,605 - 41,286,682 (-)NCBI
GRCh37641,242,999 - 41,254,457 (-)ENTREZGENE
Build 36641,351,690 - 41,362,435 (-)NCBI Archive
HuRef640,961,518 - 40,972,978 (-)ENTREZGENE
CHM1_1641,244,595 - 41,257,735 (-)NCBI
Sequence:
RefSeq Acc Id: NR_136332
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,267,385 - 41,286,682 (-)NCBI
CHM1_1641,238,399 - 41,257,735 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006715117   ⟹   XP_006715180
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,268,019 - 41,286,682 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011514696   ⟹   XP_011512998
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,267,385 - 41,286,692 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011514697   ⟹   XP_011512999
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,281,186 - 41,286,682 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010956   ⟹   XP_016866445
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,267,385 - 41,286,692 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010957   ⟹   XP_016866446
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,267,385 - 41,286,682 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001229519   ⟸   NM_001242590
- Peptide Label: isoform 3 precursor
- UniProtKB: Q9NP99 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_061113   ⟸   NM_018643
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9NP99 (UniProtKB/Swiss-Prot),   Q38L15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001229518   ⟸   NM_001242589
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9NP99 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006715180   ⟸   XM_006715117
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011512998   ⟸   XM_011514696
- Peptide Label: isoform X1
- UniProtKB: K7EKM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011512999   ⟸   XM_011514697
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016866445   ⟸   XM_017010956
- Peptide Label: isoform X2
- UniProtKB: Q9NP99 (UniProtKB/Swiss-Prot),   Q38L15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016866446   ⟸   XM_017010957
- Peptide Label: isoform X3
- UniProtKB: Q9NP99 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000334284   ⟸   ENST00000334475
RefSeq Acc Id: ENSP00000244709   ⟸   ENST00000244709
RefSeq Acc Id: ENSP00000465688   ⟸   ENST00000589614
RefSeq Acc Id: ENSP00000465345   ⟸   ENST00000591620
Protein Domains
IG   Ig-like V-type

Promoters
RGD ID:7207993
Promoter ID:EPDNEW_H9740
Type:initiation region
Name:TREM1_1
Description:triggering receptor expressed on myeloid cells 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,286,682 - 41,286,742EPDNEW
RGD ID:6804883
Promoter ID:HG_KWN:53521
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:ENST00000244709,   UC003OQG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36641,362,221 - 41,362,721 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p21.2-21.1(chr6:37777369-45653843)x1 copy number loss See cases [RCV000052181] Chr6:37777369..45653843 [GRCh38]
Chr6:37745145..45621580 [GRCh37]
Chr6:37853123..45729558 [NCBI36]
Chr6:6p21.2-21.1
pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_018643.5(TREM1):c.633T>C (p.Ala211=) single nucleotide variant not provided [RCV000946945] Chr6:41276197 [GRCh38]
Chr6:41243935 [GRCh37]
Chr6:6p21.1
benign
NM_018643.5(TREM1):c.345C>T (p.Ile115=) single nucleotide variant not provided [RCV000904060] Chr6:41282456 [GRCh38]
Chr6:41250194 [GRCh37]
Chr6:6p21.1
likely benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
NM_018643.5(TREM1):c.404A>C (p.Lys135Thr) single nucleotide variant not provided [RCV000897119] Chr6:41282397 [GRCh38]
Chr6:41250135 [GRCh37]
Chr6:6p21.1
benign
NM_018643.5(TREM1):c.642C>G (p.Phe214Leu) single nucleotide variant not provided [RCV000946944] Chr6:41276188 [GRCh38]
Chr6:41243926 [GRCh37]
Chr6:6p21.1
benign
GRCh37/hg19 6p21.1(chr6:41200840-41331797)x1 copy number loss not provided [RCV001005794] Chr6:41200840..41331797 [GRCh37]
Chr6:6p21.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17760 AgrOrtholog
COSMIC TREM1 COSMIC
Ensembl Genes ENSG00000124731 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000244709 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000334284 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000465345 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000465688 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000244709 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000334475 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000589614 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000591620 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000124731 GTEx
HGNC ID HGNC:17760 ENTREZGENE
Human Proteome Map TREM1 Human Proteome Map
InterPro Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TREM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:54210 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54210 ENTREZGENE
OMIM 605085 OMIM
PANTHER PTHR19357:SF0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA38467 PharmGKB
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt K7EKM5 ENTREZGENE, UniProtKB/TrEMBL
  Q38L15 ENTREZGENE, UniProtKB/TrEMBL
  Q9NP99 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B4DWG2 UniProtKB/Swiss-Prot
  K7EJW1 UniProtKB/Swiss-Prot
  Q53FL8 UniProtKB/Swiss-Prot
  Q5T2C9 UniProtKB/Swiss-Prot
  Q86YU1 UniProtKB/Swiss-Prot