Trem1 (triggering receptor expressed on myeloid cells 1) - Rat Genome Database

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Gene: Trem1 (triggering receptor expressed on myeloid cells 1) Mus musculus
Analyze
Symbol: Trem1
Name: triggering receptor expressed on myeloid cells 1
RGD ID: 1319824
MGI Page MGI
Description: Predicted to enable scaffold protein binding activity. Acts upstream of or within neutrophil chemotaxis; neutrophil extravasation; and neutrophil-mediated killing of gram-negative bacterium. Predicted to be located in plasma membrane. Is expressed in bladder and renal vasculature. Human ortholog(s) of this gene implicated in bacterial pneumonia; bacterial sepsis; malaria; and myocardial infarction. Orthologous to human TREM1 (triggering receptor expressed on myeloid cells 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: TREM-1; triggering receptor expressed in monocytes 1
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,539,763 - 48,553,955 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,539,796 - 48,553,952 (+)EnsemblGRCm39 Ensembl
GRCm381748,232,713 - 48,246,927 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,232,768 - 48,246,924 (+)EnsemblGRCm38mm10GRCm38
MGSCv371748,371,922 - 48,386,091 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361747,698,178 - 47,712,333 (+)NCBIMGSCv36mm8
Celera1751,668,001 - 51,682,161 (+)NCBICelera
Cytogenetic Map17CNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Triggering receptor expressed on myeloid cells 1 (TREM-1) and cytokine gene variants in complicated and uncomplicated malaria. Adukpo S, etal., Trop Med Int Health. 2016 Dec;21(12):1592-1601. doi: 10.1111/tmi.12787. Epub 2016 Oct 24.
2. TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction. Boufenzer A, etal., Circ Res. 2015 May 22;116(11):1772-82. doi: 10.1161/CIRCRESAHA.116.305628. Epub 2015 Apr 3.
3. Triggering receptor expressed on myeloid cells-1 (TREM-1) modulates immune responses to Aspergillus fumigatus during fungal asthma in mice. Buckland KF, etal., Immunol Invest. 2011;40(7-8):692-722. doi: 10.3109/08820139.2011.578270. Epub 2011 May 19.
4. Triggering receptor expressed on myeloid cells (TREM)-1 participates in Schistosoma mansoni inflammatory responses. Cheng PC, etal., Parasite Immunol. 2011 May;33(5):276-86. doi: 10.1111/j.1365-3024.2011.01284.x.
5. Soluble triggering receptor expressed on myeloid cells 1: a biomarker for bacterial meningitis. Determann RM, etal., Intensive Care Med. 2006 Aug;32(8):1243-7. doi: 10.1007/s00134-006-0240-4. Epub 2006 Jun 20.
6. Triptolide Modulates TREM-1 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis. Fan D, etal., Int J Mol Sci. 2016 Apr 2;17(4):498. doi: 10.3390/ijms17040498.
7. Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC. Fang K, etal., Front Pharmacol. 2020 Jan 17;10:1544. doi: 10.3389/fphar.2019.01544. eCollection 2019.
8. Role of TREM-1 in pulmonary tuberculosis patients- analysis of serum soluble TREM-1 levels. Feng JY, etal., Sci Rep. 2018 May 29;8(1):8223. doi: 10.1038/s41598-018-26478-2.
9. Effects of the TREM-1 pathway modulation during mesenteric ischemia-reperfusion in rats. Gibot S, etal., Crit Care Med. 2008 Feb;36(2):504-10. doi: 10.1097/01.CCM.0B013E318161FAF3.
10. TREM-1 promotes survival during septic shock in mice. Gibot S, etal., Eur J Immunol. 2007 Feb;37(2):456-66. doi: 10.1002/eji.200636387.
11. Modulation of the triggering receptor expressed on myeloid cells-1 pathway during pneumonia in rats. Gibot S, etal., J Infect Dis. 2006 Oct 1;194(7):975-83. doi: 10.1086/506950. Epub 2006 Aug 29.
12. Effects of the TREM 1 pathway modulation during hemorrhagic shock in rats. Gibot S, etal., Shock. 2009 Dec;32(6):633-7. doi: 10.1097/SHK.0b013e3181a53842.
13. In familial Mediterranean fever, soluble TREM-1 plasma level is higher in case of amyloidosis. Gorlier C, etal., Innate Immun. 2019 Nov;25(8):487-490. doi: 10.1177/1753425919870847. Epub 2019 Aug 31.
14. Triggering receptor expressed on myeloid cells-1 (TREM-1) improves host defence in pneumococcal pneumonia. Hommes TJ, etal., J Pathol. 2014 Aug;233(4):357-67. doi: 10.1002/path.4361. Epub 2014 Jun 3.
15. HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells. Hyun J, etal., PLoS Pathog. 2019 Jul 1;15(7):e1007883. doi: 10.1371/journal.ppat.1007883. eCollection 2019 Jul.
16. Forsythoside B protects against experimental sepsis by modulating inflammatory factors. Jiang WL, etal., Phytother Res. 2012 Jul;26(7):981-7. doi: 10.1002/ptr.3668. Epub 2011 Dec 6.
17. Role of triggering receptor expressed on myeloid cells-1 in experimental severe acute pancreatitis. Kamei K, etal., J Hepatobiliary Pancreat Sci. 2010 May;17(3):305-12. doi: 10.1007/s00534-009-0191-6. Epub 2009 Sep 29.
18. Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia. Knapp S, etal., J Immunol. 2004 Dec 15;173(12):7131-4. doi: 10.4049/jimmunol.173.12.7131.
19. Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils. Kozik JH, etal., Sci Rep. 2016 Jun 22;6:28556. doi: 10.1038/srep28556.
20. Amniotic fluid sTREM-1 in normal pregnancy, spontaneous parturition at term and preterm, and intra-amniotic infection/inflammation. Kusanovic JP, etal., J Matern Fetal Neonatal Med. 2010 Jan;23(1):34-47. doi: 10.3109/14767050903009248.
21. TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia. Lagler H, etal., J Immunol. 2009 Aug 1;183(3):2027-36. doi: 10.4049/jimmunol.0803862. Epub 2009 Jul 13.
22. TREM-1-targeting LP17 attenuates cerebral ischemia-induced neuronal injury by inhibiting oxidative stress and pyroptosis. Liang YB, etal., Biochem Biophys Res Commun. 2020 Aug 27;529(3):554-561. doi: 10.1016/j.bbrc.2020.05.056. Epub 2020 Jul 15.
23. TREM-1 promotes survival during Klebsiella pneumoniae liver abscess in mice. Lin YT, etal., Infect Immun. 2014 Mar;82(3):1335-42. doi: 10.1128/IAI.01347-13. Epub 2014 Jan 6.
24. High Expression Levels of Trigger Receptor Expressed on Myeloid Cells-1 on Neutrophils Associated with Increased Severity of Acute Pancreatitis in Mice. Liu M, etal., Biol Pharm Bull. 2015;38(10):1450-7. doi: 10.1248/bpb.b15-00057. Epub 2015 Aug 5.
25. Effects of the TREM-1 pathway modulation during empyema in rats. Luo L, etal., Chin Med J (Engl). 2010 Jun;123(12):1561-5.
26. MGDs mouse GO annotations MGD data from the GO Consortium
27. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
28. Mouse MP Annotation Import Pipeline RGD automated import pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Triggering receptor expressed on myeloid cells-1 (TREM-1) expression on gastric epithelium: implication for a role of TREM-1 in Helicobacter pylori infection. Schmausser B, etal., Clin Exp Immunol. 2008 Apr;152(1):88-94. doi: 10.1111/j.1365-2249.2008.03608.x.
31. Value of soluble TREM-1, procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bacteremia among sepsis patients with new fever in intensive care units: a prospective cohort study. Su L, etal., BMC Infect Dis. 2012 Jul 18;12:157. doi: 10.1186/1471-2334-12-157.
32. Role of TREM-1 in the development of early brain injury after subarachnoid hemorrhage. Sun XG, etal., Exp Neurol. 2021 Jul;341:113692. doi: 10.1016/j.expneurol.2021.113692. Epub 2021 Mar 13.
33. Inhibition of TREM-1 attenuates early brain injury after subarachnoid hemorrhage via downregulation of p38MAPK/MMP-9 and preservation of ZO-1. Sun XG, etal., Neuroscience. 2019 May 15;406:369-375. doi: 10.1016/j.neuroscience.2019.03.032. Epub 2019 Mar 23.
34. Association of Inflammatory Responses and ECM Disorganization with HMGB1 Upregulation and NLRP3 Inflammasome Activation in the Injured Rotator Cuff Tendon. Thankam FG, etal., Sci Rep. 2018 Jun 11;8(1):8918. doi: 10.1038/s41598-018-27250-2.
35. Azithromycin acts as an immunomodulatory agent to suppress the expression of TREM-1 in Bacillus pyocyaneus-induced sepsis. Tong J, etal., Immunol Lett. 2011 Aug 30;138(2):137-43. doi: 10.1016/j.imlet.2011.04.001. Epub 2011 Apr 9.
36. Gene expression analysis of TREM1 and GRK2 in polymorphonuclear leukocytes as the surrogate biomarkers of acute bacterial infections. Ubagai T, etal., Int J Med Sci. 2014 Jan 10;11(2):215-21. doi: 10.7150/ijms.7231. eCollection 2014.
37. Evaluation of TREM1 gene expression in circulating polymorphonuclear leukocytes and its inverse correlation with the severity of pathophysiological conditions in patients with acute bacterial infections. Ubagai T, etal., Jpn J Infect Dis. 2012;65(5):376-82. doi: 10.7883/yoken.65.376.
38. TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance. Weber B, etal., PLoS Pathog. 2014 Jan;10(1):e1003900. doi: 10.1371/journal.ppat.1003900. Epub 2014 Jan 16.
39. [The effect of signal transduction pathway of triggering receptor-1 expressed on myeloid cells in acute lung injury induced by paraquat in rats]. Wei M, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015 Sep;33(9):646-51.
40. Expression profile and function of triggering receptor expressed on myeloid cells-1 during melioidosis. Wiersinga WJ, etal., J Infect Dis. 2007 Dec 1;196(11):1707-16. doi: 10.1086/522141. Epub 2007 Oct 25.
41. [Temporal expression of triggering receptors expressed by myeloid cells-1 during the development of experimental periodontitis in rat]. Wu WC, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 2018 Mar 9;53(3):157-163. doi: 10.3760/cma.j.issn.1002-0098.2018.03.003.
42. Shengxian decoction decreases doxorubicin‑induced cardiac apoptosis by regulating the TREM1/NF‑κB signaling pathway. Yao L, etal., Mol Med Rep. 2021 Mar;23(3). pii: 219. doi: 10.3892/mmr.2021.11858. Epub 2021 Jan 26.
43. Active vitamin D regulates macrophage M1/M2 phenotypes via the STAT-1-TREM-1 pathway in diabetic nephropathy. Zhang X, etal., J Cell Physiol. 2019 May;234(5):6917-6926. doi: 10.1002/jcp.27450. Epub 2018 Nov 27.
44. Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats. Zhao Y, etal., Mol Cell Endocrinol. 2018 Sep 15;473:44-52. doi: 10.1016/j.mce.2018.01.001. Epub 2018 Jan 10.
45. Inhibition of TREM-1 and Dectin-1 Alleviates the Severity of Fungal Keratitis by Modulating Innate Immune Responses. Zhong J, etal., PLoS One. 2016 Mar 10;11(3):e0150114. doi: 10.1371/journal.pone.0150114. eCollection 2016.
46. Inhibition of triggering receptor expressed on myeloid cells-1 ameliorates experimental autoimmune neuritis. Zhou X, etal., Mol Med Rep. 2017 Apr;15(4):1565-1570. doi: 10.3892/mmr.2017.6167. Epub 2017 Feb 6.
47. TREM-1 deficiency attenuates the inflammatory responses in LPS-induced murine endometritis. Zhu H, etal., Microb Biotechnol. 2019 Nov;12(6):1337-1345. doi: 10.1111/1751-7915.13467. Epub 2019 Jul 31.
Additional References at PubMed
PMID:10349636   PMID:10799849   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11754004   PMID:12477932   PMID:15557347   PMID:15561137   PMID:16141072   PMID:16141073   PMID:17202378  
PMID:17634956   PMID:17905855   PMID:18287559   PMID:19120482   PMID:19479878   PMID:19904768   PMID:20197606   PMID:20797396   PMID:21267068   PMID:21308778   PMID:21555403   PMID:21677750  
PMID:21683719   PMID:21873635   PMID:22055202   PMID:22719066   PMID:23241959   PMID:23463907   PMID:23475790   PMID:23571837   PMID:23810411   PMID:23844229   PMID:24358193   PMID:24711453  
PMID:24918157   PMID:24959004   PMID:26056380   PMID:26277357   PMID:26684249   PMID:26738569   PMID:26782119   PMID:27083877   PMID:27189410   PMID:27237091   PMID:27244892   PMID:27568523  
PMID:27762264   PMID:27928159   PMID:27940256   PMID:28004759   PMID:28089248   PMID:28440307   PMID:28610717   PMID:28824642   PMID:28837205   PMID:29080545   PMID:29093489   PMID:29361046  
PMID:29543509   PMID:29730341   PMID:29869715   PMID:30055735   PMID:30137027   PMID:30551457   PMID:30555461   PMID:30667543   PMID:30681755   PMID:30810243   PMID:31189465   PMID:31263278  
PMID:31275318   PMID:31324751   PMID:31324779   PMID:32027618   PMID:32462028   PMID:32506691   PMID:32984356   PMID:33049389   PMID:33258804   PMID:33420354   PMID:33525982   PMID:33947214  
PMID:33957479   PMID:34097504   PMID:34125599   PMID:34374795   PMID:34719965   PMID:34750987   PMID:35075692   PMID:35130556   PMID:35177426   PMID:35306429   PMID:35443564   PMID:35487953  
PMID:36330909   PMID:36594089  


Genomics

Comparative Map Data
Trem1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,539,763 - 48,553,955 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,539,796 - 48,553,952 (+)EnsemblGRCm39 Ensembl
GRCm381748,232,713 - 48,246,927 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,232,768 - 48,246,924 (+)EnsemblGRCm38mm10GRCm38
MGSCv371748,371,922 - 48,386,091 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361747,698,178 - 47,712,333 (+)NCBIMGSCv36mm8
Celera1751,668,001 - 51,682,161 (+)NCBICelera
Cytogenetic Map17CNCBI
TREM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,267,385 - 41,286,682 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl641,267,926 - 41,286,682 (-)EnsemblGRCh38hg38GRCh38
GRCh37641,235,123 - 41,254,420 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,351,690 - 41,362,435 (-)NCBINCBI36Build 36hg18NCBI36
Build 34641,351,689 - 41,362,435NCBI
Celera642,797,142 - 42,807,885 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,961,518 - 40,972,978 (-)NCBIHuRef
CHM1_1641,246,251 - 41,257,709 (-)NCBICHM1_1
T2T-CHM13v2.0641,096,688 - 41,115,965 (-)NCBIT2T-CHM13v2.0
Trem1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2912,763,819 - 12,779,285 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,763,819 - 12,779,203 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx921,277,179 - 21,288,238 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0926,343,405 - 26,354,464 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0924,732,622 - 24,743,689 (-)NCBIRnor_WKY
Rnor_6.0914,727,887 - 14,743,371 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,727,976 - 14,809,447 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0913,649,246 - 13,664,645 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,175,081 - 8,186,142 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.198,175,083 - 8,193,441 (-)NCBI
Celera910,535,490 - 10,546,547 (-)NCBICelera
Cytogenetic Map9q12NCBI
TREM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1642,168,992 - 42,182,134 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,163,337 - 42,183,091 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0640,861,283 - 40,874,446 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TREM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1129,990,678 - 10,000,195 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl129,990,679 - 10,000,236 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1210,020,952 - 10,030,132 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01210,470,281 - 10,479,802 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1210,470,277 - 10,479,839 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11210,002,655 - 10,011,845 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01210,084,374 - 10,093,559 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01210,179,448 - 10,188,597 (-)NCBIUU_Cfam_GSD_1.0
Trem1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,374,752 - 45,385,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647618,574,381 - 18,583,647 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647618,577,825 - 18,583,675 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TREM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,510,253 - 36,531,796 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1736,510,253 - 36,531,796 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2741,804,122 - 41,825,672 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TREM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,873,647 - 30,885,292 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,873,666 - 30,886,967 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604441,275,669 - 41,288,974 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1407
Count of miRNA genes:520
Interacting mature miRNAs:587
Transcripts:ENSMUST00000048782, ENSMUST00000113251
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173311897454107028Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173517581770165926Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173596629469966424Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173678974370789743Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173871288772712970Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173880562672805626Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173880562672805626Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4053444774534623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174093918774939187Mouse
4141478Hbnr7_mHeligmosomoides bakeri nematode resistance 7 (mouse)Not determined4305118551739122Mouse
26884386Skwq13_mskull length QTL 13, 16 week (mouse)174371089153107028Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174371089167806995Mouse
12903997Cfq4_mconditioned fear QTL 4 (mouse)174501655249366402Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174651092682407429Mouse
35673315Ari1_mantibody response to influenza 1, day 7, IgG2a+IgG2c (mouse)174731092654707028Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000048782   ⟹   ENSMUSP00000038636
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1748,539,799 - 48,553,952 (+)Ensembl
GRCm38.p6 Ensembl1748,232,771 - 48,246,924 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113251   ⟹   ENSMUSP00000108877
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1748,539,796 - 48,553,390 (+)Ensembl
GRCm38.p6 Ensembl1748,232,768 - 48,246,362 (+)Ensembl
RefSeq Acc Id: NM_001347399   ⟹   NP_001334328
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391748,539,767 - 48,553,952 (+)NCBI
GRCm381748,232,739 - 48,246,924 (+)NCBI
Sequence:
RefSeq Acc Id: NM_021406   ⟹   NP_067381
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391748,539,767 - 48,553,952 (+)NCBI
GRCm381748,232,739 - 48,246,924 (+)NCBI
MGSCv371748,371,922 - 48,386,091 (+)RGD
Celera1751,667,982 - 51,682,161 (+)NCBI
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006524726   ⟹   XP_006524789
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391748,542,096 - 48,553,955 (+)NCBI
GRCm381748,234,862 - 48,246,927 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006524728   ⟹   XP_006524791
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391748,541,890 - 48,553,955 (+)NCBI
GRCm381748,234,862 - 48,246,927 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006524729   ⟹   XP_006524792
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391748,539,763 - 48,553,955 (+)NCBI
GRCm381748,232,713 - 48,246,927 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036160714   ⟹   XP_036016607
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391748,539,771 - 48,550,058 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_067381   ⟸   NM_021406
- Peptide Label: isoform 1 precursor
- UniProtKB: Q3TAL7 (UniProtKB/Swiss-Prot),   Q9JKE2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006524792   ⟸   XM_006524729
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006524789   ⟸   XM_006524726
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006524791   ⟸   XM_006524728
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001334328   ⟸   NM_001347399
- Peptide Label: isoform 2 precursor
- UniProtKB: Q14DT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000108877   ⟸   ENSMUST00000113251
RefSeq Acc Id: ENSMUSP00000038636   ⟸   ENSMUST00000048782
RefSeq Acc Id: XP_036016607   ⟸   XM_036160714
- Peptide Label: isoform X1
Protein Domains
Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKE2-F1-model_v2 AlphaFold Q9JKE2 1-230 view protein structure

Promoters
RGD ID:13676344
Promoter ID:EPDNEW_M22321
Type:multiple initiation site
Name:Trem1_1
Description:Mus musculus triggering receptor expressed on myeloid cells 1, transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381748,232,771 - 48,232,831EPDNEW
RGD ID:6828818
Promoter ID:MM_KWN:23752
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:NM_021406_TREM1,   OTTMUST00000040924,   OTTMUST00000048305
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361748,371,721 - 48,372,221 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930005 AgrOrtholog
Ensembl Genes ENSMUSG00000042265 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000038636 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000108877 ENTREZGENE
  ENSMUSP00000108877.4 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000048782 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000113251 ENTREZGENE
  ENSMUST00000113251.10 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
  TREM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:58217 UniProtKB/Swiss-Prot
MGD MGI:1930005 ENTREZGENE
NCBI Gene 58217 ENTREZGENE
PANTHER PTHR19357:SF0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot
PhenoGen Trem1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
SMART SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt Q14DT9 ENTREZGENE, UniProtKB/TrEMBL
  Q3TAL7 ENTREZGENE
  Q9JKE2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3TAL7 UniProtKB/Swiss-Prot