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losartan - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:losartan
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Accession:CHEBI:6541 term browser browse the term
Definition:A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Synonyms:exact_synonym: (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol
 related_synonym: (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol;   2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole;   Formula=C22H22ClN6O.K;   Formula=C22H23ClN6O;   InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28);   InChIKey=PSIFNNKUMBGKDQ-UHFFFAOYSA-N;   SMILES=CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
 xref: CAS:114798-26-4;   DrugBank:DB00678;   Drug_Central:1610;   HMDB:HMDB0014816;   KEGG:C07072;   KEGG:D08146;   LINCS:LSM-3701
 xref_mesh: MESH:D019808
 xref: PMID:11115412;   PMID:11589260;   PMID:12561964;   PMID:15703421;   PMID:18800450;   PMID:18800451;   PMID:18800458;   PMID:18940180;   PMID:31299855;   PMID:31613648;   PMID:31636311;   PMID:31893179;   PMID:32048541;   Patent:EP253310;   Patent:US5138069;   Reaxys:4770867;   Wikipedia:Losartan
 cyclic_relationship: is_conjugate_acid_of CHEBI:149504

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losartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 ISO Losartan results in decreased activity of ABCB11 protein
Losartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:23956101 PMID:24014644 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
decreases expression		 ISO
EXP		 Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of ACE protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]
Losartan results in decreased expression of ACE protein
Losartan inhibits the reaction [Testosterone results in increased activity of ACE protein]		 CTD PMID:25511041 PMID:25655897 PMID:25673179 PMID:28091615 PMID:28578904 More... NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions
increases activity
increases expression		 EXP
ISO		 Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of ACE2 protein]
Losartan results in increased activity of ACE2 protein
Losartan results in increased expression of ACE2 protein
Losartan results in increased expression of ACE2 mRNA; Losartan results in increased expression of ACE2 protein
Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]		 CTD PMID:15897343 PMID:16176966 PMID:16221218 PMID:20178811 PMID:22009550 More... NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of ACTA2 mRNA; Losartan results in decreased expression of ACTA2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]		 CTD PMID:15100363 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actg2 actin gamma 2, smooth muscle decreases expression EXP Losartan results in decreased expression of ACTG2 mRNA CTD PMID:15100363 NCBI chr 4:117,579,513...117,604,379
Ensembl chr 4:116,021,832...116,046,465 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Losartan results in increased expression of ADIPOQ mRNA CTD PMID:19730415 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adrb2 adrenoceptor beta 2 affects expression EXP Losartan affects the expression of ADRB2 protein CTD PMID:9260993 NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Afp alpha-fetoprotein multiple interactions ISO Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:29859236 NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Losartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Losartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]] CTD PMID:22467055 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen multiple interactions
decreases activity
decreases expression
increases expression
decreases response to substance
increases secretion		 ISO
EXP		 [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein]; [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [pyruvamide binds to AGT protein modified form]]; Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in decreased secretion of Nitric Oxide]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Losartan inhibits the reaction [AGT protein promotes the reaction [[Medroxyprogesterone Acetate co-treated with Bucladesine] results in increased secretion of PRL protein]]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of CXCL8 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of MMP2 protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]
Losartan results in decreased activity of AGT protein
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein]; Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of DES protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
[Lisinopril co-treated with Losartan] results in increased expression of AGT mRNA; [Losartan co-treated with Carvedilol] results in decreased susceptibility to AGT protein modified form; Carvedilol inhibits the reaction [Losartan results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [AGT protein affects the abundance of Cholesterol]; Losartan inhibits the reaction [AGT protein affects the localization of Calcium]; Losartan inhibits the reaction [AGT protein affects the localization of Lipids]; Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form]; Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein]; Losartan inhibits the reaction [AGT protein results in decreased abundance of NADP]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased abundance of Fatty Acids, Nonesterified]; Losartan inhibits the reaction [AGT protein results in increased abundance of Glycerol]; Losartan inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Losartan inhibits the reaction [AGT protein results in increased abundance of Triglycerides]; Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CYBA mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein]; Losartan inhibits the reaction [AGT protein results in increased expression of NCF2 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Losartan inhibits the reaction [Carvedilol results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [Ethanol results in increased secretion of AGT protein alternative form]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]; Losartan inhibits the reaction [Folic Acid results in increased localization of AGT protein]; Losartan inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Losartan inhibits the reaction [Sodium Chloride results in increased expression of AGT protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of AGT protein]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of AGT protein]
Losartan results in decreased expression of AGT protein; Losartan results in decreased expression of AGT protein alternative form; Losartan results in decreased expression of AGT protein modified form
Losartan results in increased expression of AGT protein
Losartan results in decreased activity of AGT protein; Losartan results in decreased activity of AGT protein modified form
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein; Losartan results in decreased activity of AGT protein
Losartan results in increased secretion of AGT protein; Losartan results in increased secretion of AGT protein alternative form		 CTD PMID:1387008 PMID:7965263 PMID:8403307 PMID:8952583 PMID:9124547 More... NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
decreases activity
increases expression
decreases expression		 ISO
EXP		 [Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]
[Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]
Losartan results in increased expression of AGTR1 mRNA; Losartan results in increased expression of AGTR1A mRNA
Losartan results in decreased expression of AGTR1 protein; Losartan results in decreased expression of AGTR1A mRNA; Losartan results in decreased expression of AGTR1A protein
Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]		 CTD PMID:9124547 PMID:9533614 PMID:10821809 PMID:11893553 PMID:12930639 More... NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
decreases expression
increases expression		 EXP
ISO		 [Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]
Losartan results in decreased expression of AGTR2 mRNA
Losartan results in increased expression of AGTR2 protein
Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of AGTR2 protein]		 CTD PMID:9336375 PMID:11967826 PMID:15331931 PMID:18300857 PMID:25511041 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein] CTD PMID:28578904 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Alb albumin affects binding ISO Losartan binds to ALB protein; Losartan binds to ALB protein modified form CTD PMID:27470663 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression EXP Losartan results in decreased expression of ALOX15 mRNA; Losartan results in decreased expression of ALOX15 protein CTD PMID:15100363 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases expression EXP Losartan results in decreased expression of ALOX5 protein CTD PMID:21377515 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression
multiple interactions		 ISO Losartan results in decreased expression of AMBP protein
benazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]; Losartan promotes the reaction [benazepril results in decreased expression of AMBP protein]		 CTD PMID:16303729 NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:76,568,094...76,578,331 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA] CTD PMID:14630723 NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 increases expression EXP Losartan results in increased expression of ATP1A2 mRNA; Losartan results in increased expression of ATP1A2 protein CTD PMID:18418421 NCBI chr13:87,261,964...87,286,911
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression EXP Losartan results in decreased expression of ATP1A3 mRNA; Losartan results in decreased expression of ATP1A3 protein CTD PMID:18418421 NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:80,572,796...80,601,918 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAK1 mRNA] CTD PMID:15502641 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
increases expression		 EXP Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA]
Losartan results in decreased expression of BAX mRNA
Losartan results in increased expression of BAX protein		 CTD PMID:12623880 PMID:12845756 PMID:15502641 PMID:17784886 PMID:19298698 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression
affects expression		 EXP Losartan promotes the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 mRNA]
Losartan results in decreased expression of BCL2 protein
Losartan results in increased expression of BCL2 protein
Losartan affects the expression of BCL2 protein		 CTD PMID:12623880 PMID:15502641 PMID:19298698 PMID:21153712 PMID:22000973 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein] CTD PMID:27412937 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO [KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]; Losartan inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein] CTD PMID:25103225 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
decreases activity		 EXP Losartan results in increased cleavage of CASP3 protein
Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Losartan inhibits the reaction [Testosterone results in increased activity of CASP3 protein]
Losartan results in decreased activity of CASP3 protein		 CTD PMID:12623880 PMID:23300732 PMID:23875703 PMID:25673179 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 decreases activity EXP Losartan results in decreased activity of CASP8 protein CTD PMID:23875703 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage EXP Losartan results in increased cleavage of CASP9 protein CTD PMID:12623880 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase decreases expression
multiple interactions		 EXP Losartan results in decreased expression of CAT protein
Losartan inhibits the reaction [Streptozocin results in decreased activity of CAT protein]		 CTD PMID:23875703 PMID:30958922 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 EXP
ISO		 Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]; Losartan inhibits the reaction [glyoxylic acid results in increased expression of CCL2 protein]
Losartan results in decreased expression of CCL2 mRNA; Losartan results in decreased expression of CCL2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]		 CTD PMID:10925121 PMID:16284884 PMID:17922026 PMID:19553526 PMID:28578904 More... NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL3 protein] CTD PMID:19553526 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:29859236 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression EXP Losartan results in decreased expression of CCR2 mRNA CTD PMID:17922026 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions
decreases expression		 ISO Losartan results in increased expression of CD36 mRNA
T 0070907 inhibits the reaction [Losartan results in increased expression of CD36 mRNA]
Losartan promotes the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of CD36 mRNA]
Losartan results in decreased expression of CD36 mRNA		 CTD PMID:18302760 PMID:22124178 NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd44 CD44 molecule multiple interactions EXP Losartan inhibits the reaction [glyoxylic acid results in increased expression of CD44 protein] CTD PMID:37454925 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd74 CD74 molecule decreases expression EXP Losartan results in decreased expression of CD74 mRNA CTD PMID:15100363 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]
Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]		 CTD PMID:28578904 PMID:33007385 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein] CTD PMID:33380422 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of COL1A1 mRNA
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL1A1 mRNA]		 CTD PMID:15100363 PMID:18300870 PMID:23585870 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of COL3A1 mRNA
Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of COL3A1 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL3A1 mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]		 CTD PMID:15100363 PMID:16539842 PMID:23585870 PMID:25233898 PMID:28578904 More... NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression EXP Losartan results in decreased expression of COL4A1 mRNA CTD PMID:16191423 NCBI chr16:84,885,597...84,996,482
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA] CTD PMID:19109942 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [Folic Acid results in increased activity of CREB1 protein] CTD PMID:15728788 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crp C-reactive protein multiple interactions EXP Dexamethasone promotes the reaction [Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CRP protein]]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CRP protein] CTD PMID:32812458 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]		 CTD PMID:28578904 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cubn cubilin multiple interactions EXP Losartan inhibits the reaction [Cadmium results in decreased expression of CUBN protein] CTD PMID:24093454 NCBI chr17:81,293,619...81,501,694
Ensembl chr17:76,385,060...76,593,231 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CXCL1 protein] CTD PMID:19553526 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of CYBA mRNA] CTD PMID:38356441 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cycs cytochrome c, somatic increases expression EXP Losartan results in increased expression of CYCS protein CTD PMID:18971572 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Losartan results in increased expression of CYP1A1 mRNA CTD PMID:9860486 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dcn decorin decreases expression EXP Losartan results in decreased expression of DCN mRNA CTD PMID:15100363 NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Des desmin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of DES protein] CTD PMID:28578904 NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions		 ISO
EXP		 Losartan results in decreased expression of EDN1 protein
Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]
Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]
Losartan results in decreased expression of EDN1 mRNA; Losartan results in decreased expression of EDN1 protein		 CTD PMID:11369837 PMID:12901495 PMID:16191423 PMID:17666345 PMID:18971572 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A multiple interactions
decreases expression		 EXP Atorvastatin promotes the reaction [Losartan results in decreased expression of EDNRA mRNA]; Losartan promotes the reaction [Atorvastatin results in decreased expression of EDNRA mRNA] CTD PMID:23091284 NCBI chr19:47,137,360...47,207,961
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein] CTD PMID:25398788 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eln elastin decreases expression EXP Losartan results in decreased expression of ELN mRNA CTD PMID:15100363 NCBI chr12:27,604,983...27,648,413
Ensembl chr12:21,968,544...22,011,928 		JBrowse link
G Eng endoglin multiple interactions
increases expression		 EXP
ISO		 Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein]
Losartan results in increased expression of ENG mRNA; Losartan results in increased expression of ENG protein		 CTD PMID:15539634 PMID:32947957 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G F3 coagulation factor III, tissue factor decreases expression
multiple interactions		 ISO Losartan results in decreased expression of F3 mRNA; Losartan results in decreased expression of F3 protein
Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]		 CTD PMID:18060435 PMID:22188725 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Faslg Fas ligand decreases expression EXP Losartan results in decreased expression of FASLG mRNA CTD PMID:10925121 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA] CTD PMID:19109942 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases expression ISO Losartan results in decreased expression of FLT1 mRNA; Losartan results in decreased expression of FLT1 protein CTD PMID:19771429 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 decreases expression ISO Losartan results in decreased expression of FLT4 mRNA CTD PMID:19771429 NCBI chr10:34,414,834...34,455,878
Ensembl chr10:33,913,608...33,954,770 		JBrowse link
G Fn1 fibronectin 1 decreases expression EXP Losartan results in decreased expression of FN1 mRNA; Losartan results in decreased expression of FN1 protein CTD PMID:16191423 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP		 Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [Furosemide results in increased expression of FOS protein]; Losartan inhibits the reaction [Polyethylene Glycols results in increased expression of FOS protein] CTD PMID:11463773 PMID:15528393 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Losartan results in increased expression of GJA1 protein CTD PMID:18971572 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO		 Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]		 CTD PMID:15573910 PMID:29859236 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein] CTD PMID:22982863 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Losartan inhibits the reaction [Cadmium results in increased expression of HAVCR1] CTD PMID:24093454 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA] CTD PMID:19109942 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 increases activity
multiple interactions
increases expression		 EXP
ISO		 Losartan results in increased activity of HMOX1 protein
cobaltiprotoporphyrin promotes the reaction [Losartan results in increased activity of HMOX1 protein]; cobaltiprotoporphyrin promotes the reaction [Losartan results in increased expression of HMOX1 mRNA]
Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]		 CTD PMID:19804535 PMID:28578904 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein] CTD PMID:25398788 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases secretion		 ISO
EXP		 Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]
Losartan results in decreased secretion of ICAM1 protein
Dexamethasone promotes the reaction [Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ICAM1 protein]]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of ICAM1 protein]		 CTD PMID:10517737 PMID:32812458 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma increases expression
multiple interactions		 EXP Losartan results in increased expression of IFNG protein
[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in decreased expression of IFNG protein]; Losartan inhibits the reaction [Amiodarone results in decreased expression of IFNG protein]		 CTD PMID:23875703 PMID:34590760 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 increases expression EXP Losartan results in increased expression of IL10 mRNA CTD PMID:18971572 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression		 ISO
EXP		 Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]
Losartan results in decreased expression of IL1A protein		 CTD PMID:17299153 PMID:23875703 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP [Vitamin D co-treated with Losartan] inhibits the reaction [Amiodarone results in increased expression of IL4 protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of IL4 protein] CTD PMID:34590760 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
increases expression		 ISO
EXP		 Losartan results in decreased expression of IL6 mRNA
[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased expression of IL6 protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of IL6 protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Losartan inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]
Losartan results in increased expression of IL6 protein		 CTD PMID:16284884 PMID:21479465 PMID:23875703 PMID:30677511 PMID:32947957 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itga3 integrin subunit alpha 3 decreases expression EXP Losartan results in decreased expression of ITGA3 protein CTD PMID:15100363 NCBI chr10:80,486,998...80,522,548
Ensembl chr10:79,990,161...80,022,118 		JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression EXP Losartan results in decreased expression of ITGA6 protein CTD PMID:15100363 NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions EXP Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR1 protein] CTD PMID:37454925 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 multiple interactions EXP Losartan inhibits the reaction [Calcium Oxalate results in increased expression of ITPR2 protein] CTD PMID:37454925 NCBI chr 4:180,759,325...181,165,361
Ensembl chr 4:179,027,281...179,404,164 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO losartan inhibits the reaction [Angiotensin II increases phosphorylation of JAK2 protein in liver] RGD PMID:22613986 RGD:127285667 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of JUN protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of JUN protein] CTD PMID:34590760 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP Losartan inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kng1 kininogen 1 multiple interactions EXP Losartan inhibits the reaction [bisphenol A results in increased expression of KNG1 protein] CTD PMID:38027817 NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein]; Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 4:179,916,255...179,949,613 JBrowse link
G Lox lysyl oxidase decreases expression EXP Losartan results in decreased expression of LOX mRNA CTD PMID:15100363 NCBI chr18:48,162,889...48,175,640
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Lum lumican decreases expression EXP Losartan results in decreased expression of LUM mRNA CTD PMID:15100363 NCBI chr 7:34,245,323...34,252,510
Ensembl chr 7:32,358,614...32,365,793 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases activity
increases phosphorylation		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK1 protein]; [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK1 protein]
Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]
Losartan results in increased activity of MAPK1 protein		 CTD PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression
multiple interactions		 EXP Losartan results in decreased expression of MAPK14 protein
[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK14 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK14 protein]		 CTD PMID:28091615 PMID:34590760 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases activity
increases phosphorylation		 ISO
EXP		 Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK3 protein]; [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [Amiodarone results in increased phosphorylation of MAPK3 protein]
Losartan results in increased activity of MAPK3 protein		 CTD PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein] CTD PMID:22982863 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] CTD PMID:33007385 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Mgp matrix Gla protein decreases expression EXP Losartan results in decreased expression of MGP mRNA CTD PMID:15100363 NCBI chr 4:171,497,472...171,500,888
Ensembl chr 4:169,766,279...169,769,667 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP
ISO		 Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]
Losartan inhibits the reaction [AGT protein results in increased secretion of MMP2 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]		 CTD PMID:12930639 PMID:16251426 PMID:23585870 PMID:29859236 PMID:36682589 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp23 matrix metallopeptidase 23 decreases expression EXP Losartan results in decreased expression of MMP23 mRNA CTD PMID:15100363 NCBI chr 5:171,521,905...171,525,007
Ensembl chr 5:166,239,644...166,242,433 		JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]] CTD PMID:28578904 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of MMP9 mRNA
Dexamethasone promotes the reaction [Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MMP9 protein]]; Losartan inhibits the reaction [Paraquat results in increased expression of MMP9 mRNA]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MMP9 protein]
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]		 CTD PMID:18971572 PMID:23585870 PMID:25233898 PMID:32812458 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects expression EXP Losartan affects the expression of MYC protein CTD PMID:22000973 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myh11 myosin heavy chain 11 decreases expression EXP Losartan results in decreased expression of MYH11 mRNA CTD PMID:15100363 NCBI chr10:1,250,554...1,345,681
Ensembl chr10:743,685...838,459 		JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein] CTD PMID:15362513 NCBI chr15:32,388,102...32,413,663
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 protein] CTD PMID:15362513 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Mylk myosin light chain kinase multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein] CTD PMID:18511912 NCBI chr11:79,288,243...79,535,450
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO
EXP		 Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA]
Losartan inhibits the reaction [Ethanol affects the localization of NCF1 protein]		 CTD PMID:22306536 PMID:22497828 PMID:22982071 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of NCF2 mRNA] CTD PMID:38356441 NCBI chr13:67,505,492...67,536,015
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 multiple interactions EXP Losartan inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein] CTD PMID:15793251 NCBI chr18:56,407,308...56,470,007
Ensembl chr18:54,140,779...54,178,191 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions		 EXP
ISO		 Losartan results in decreased expression of NFE2L2 mRNA
Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]		 CTD PMID:18765277 PMID:28578904 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP
ISO		 Losartan inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein]		 CTD PMID:16284884 PMID:29859236 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos1 nitric oxide synthase 1 increases phosphorylation
multiple interactions		 EXP Losartan results in increased phosphorylation of NOS1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of NOS1 protein]		 CTD PMID:20056918 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 affects expression
increases expression
decreases expression		 EXP Losartan affects the expression of NOS2 mRNA
Losartan results in increased expression of NOS2 protein
Losartan results in decreased expression of NOS2 mRNA; Losartan results in decreased expression of NOS2 protein		 CTD PMID:12198324 PMID:16191423 PMID:18390819 PMID:21377515 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 affects expression
increases phosphorylation
multiple interactions
increases expression		 EXP Losartan affects the expression of NOS3 mRNA
Losartan results in increased phosphorylation of NOS3 protein
[Losartan co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; Losartan inhibits the reaction [Sodium Chloride results in decreased expression of NOS3 protein]
Losartan results in increased expression of NOS3 mRNA		 CTD PMID:12198324 PMID:18390819 PMID:18971572 PMID:20232302 PMID:23091284 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein] CTD PMID:28578904 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression		 EXP Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPA mRNA]
Losartan results in decreased expression of NPPA protein		 CTD PMID:12198334 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression		 EXP [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Nifedipine] results in decreased expression of NPPB mRNA; Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]
Losartan results in decreased expression of NPPB mRNA; Losartan results in decreased expression of NPPB protein		 CTD PMID:12198334 PMID:15969258 PMID:17666919 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Npr1 natriuretic peptide receptor 1 affects response to substance ISO NPR1 protein mutant form affects the susceptibility to Losartan CTD PMID:20881240 NCBI chr 2:178,231,766...178,247,591
Ensembl chr 2:175,934,181...175,949,505 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression EXP Losartan results in increased expression of NR1H3 protein CTD PMID:28091615 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression EXP Losartan results in increased expression of NRF1 mRNA CTD PMID:18765277 NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP
ISO		 Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]
Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]		 CTD PMID:15502880 PMID:21613793 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions EXP Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form] CTD PMID:12431451 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein] CTD PMID:12930639 PMID:17043664 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfd platelet derived growth factor D multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA] CTD PMID:17043664 NCBI chr 8:11,773,335...12,007,277
Ensembl chr 8:3,488,423...3,722,395 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA] CTD PMID:17043664 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pdlim3 PDZ and LIM domain 3 decreases expression EXP Losartan results in decreased expression of PDLIM3 mRNA CTD PMID:15100363 NCBI chr16:53,085,020...53,116,495
Ensembl chr16:46,352,467...46,383,657 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Losartan results in decreased expression of PECAM1 mRNA CTD PMID:19771429 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Plat plasminogen activator, tissue type decreases expression EXP Losartan results in decreased expression of PLAT mRNA CTD PMID:15100363 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Podxl podocalyxin-like multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein] CTD PMID:28578904 NCBI chr 4:61,102,434...61,149,131
Ensembl chr 4:60,135,109...60,181,899 		JBrowse link
G Postn periostin multiple interactions
decreases expression		 EXP
ISO		 Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]
Losartan results in decreased expression of POSTN mRNA		 CTD PMID:15121739 PMID:21641384 PMID:32947957 NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA] CTD PMID:19109942 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO		 Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]
Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of PPARG mRNA]		 CTD PMID:18302760 PMID:19109942 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression		 EXP Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]
Losartan results in increased expression of PPARGC1A mRNA		 CTD PMID:18765277 PMID:18971572 PMID:19109942 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP Losartan inhibits the reaction [Ethanol results in increased expression of PRKCB protein] CTD PMID:22497828 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prl prolactin multiple interactions EXP
ISO		 Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein]
Losartan inhibits the reaction [AGT protein promotes the reaction [[Medroxyprogesterone Acetate co-treated with Bucladesine] results in increased secretion of PRL protein]]		 CTD PMID:14722030 PMID:36682589 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 EXP
ISO		 Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein]
Losartan results in decreased expression of PTGS2 mRNA; Losartan results in decreased expression of PTGS2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]		 CTD PMID:17244722 PMID:18267125 PMID:21377515 PMID:28578904 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions EXP Losartan inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein]; Losartan inhibits the reaction [Gentamicins results in decreased expression of PTH1R protein] CTD PMID:15728788 NCBI chr 8:119,572,295...119,597,405
Ensembl chr 8:110,697,485...110,719,729 		JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Gentamicins results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Reg3g regenerating family member 3 gamma multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA] CTD PMID:27798352 NCBI chr 4:112,482,183...112,484,738
Ensembl chr 4:110,924,168...110,926,723 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 Dexamethasone promotes the reaction [Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of RELA protein]]; Losartan inhibits the reaction [Doxorubicin results in increased expression of RELA mRNA]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of RELA protein]
Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein]		 CTD PMID:15157388 PMID:28578904 PMID:29859236 PMID:32812458 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin multiple interactions
increases expression
increases activity		 ISO
EXP		 [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]
Losartan results in increased expression of REN protein
Losartan results in increased activity of REN protein
[Lisinopril co-treated with Losartan] results in increased expression of REN mRNA; Losartan inhibits the reaction [Ethanol results in increased activity of REN protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]
Losartan results in increased expression of REN mRNA; Losartan results in increased expression of REN protein
Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]		 CTD PMID:1387008 PMID:7965263 PMID:8382237 PMID:8403307 PMID:9124547 More... NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G RT1-Da RT1 class II, locus Da decreases expression EXP Losartan results in decreased expression of RT1-DA mRNA CTD PMID:15100363 NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,512,911...4,518,455 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 decreases expression EXP Losartan results in decreased expression of RT1-S3 mRNA CTD PMID:15100363 NCBI chr20:2,675,463...2,680,229
Ensembl chr20:2,670,709...2,675,411 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein] CTD PMID:27412937 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein] CTD PMID:28578904 NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein] CTD PMID:29609002 NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA] CTD PMID:18302760 NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Sdc2 syndecan 2 decreases expression EXP Losartan results in decreased expression of SDC2 mRNA; Losartan results in decreased expression of SDC2 protein CTD PMID:15100363 NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:64,127,110...64,241,081 		JBrowse link
G Selp selectin P multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of SELP protein] CTD PMID:19553526 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 decreases response to substance EXP SFRP2 protein results in decreased susceptibility to Losartan CTD PMID:23875703 NCBI chr 2:171,387,536...171,395,081
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 decreases activity
affects response to substance
decreases expression
multiple interactions		 ISO Losartan results in decreased activity of SLC22A12 protein
SLC22A12 protein affects the susceptibility to Losartan
Losartan results in decreased expression of SLC22A12 mRNA
[Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid		 CTD PMID:18670416 PMID:20486468 NCBI chr 1:213,274,266...213,282,793
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions ISO Losartan inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid] CTD PMID:19587147 NCBI chr14:76,540,649...76,674,277
Ensembl chr14:72,328,320...72,461,981 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions ISO Losartan inhibits the reaction [Ammonium Chloride results in increased expression of NHE3 protein] CTD PMID:18287403 NCBI chr 1:30,953,215...30,996,209
Ensembl chr 1:29,124,674...29,167,417 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]] CTD PMID:28578904 NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Sod2 superoxide dismutase 2 decreases activity EXP Losartan results in decreased activity of SOD2 protein CTD PMID:18765277 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein] CTD PMID:10400907 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Sparc secreted protein acidic and cysteine rich decreases expression EXP Losartan results in decreased expression of SPARC mRNA CTD PMID:15100363 NCBI chr10:40,017,065...40,038,816
Ensembl chr10:39,516,406...39,538,396 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Losartan inhibits the reaction [glyoxylic acid results in increased expression of SPP1 protein] CTD PMID:37454925 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein] CTD PMID:19109942 PMID:25398788 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Losartan results in decreased phosphorylation of STAT3 protein CTD PMID:33380422 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases secretion
multiple interactions
increases expression
decreases expression
decreases activity		 ISO
EXP		 Losartan results in decreased secretion of TGFB1 protein
[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; [Losartan co-treated with Nifedipine] results in decreased expression of TGFB1 mRNA; [Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TGFB1 protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
Losartan results in increased expression of TGFB1 protein
Losartan results in decreased expression of TGFB1 mRNA; Losartan results in decreased expression of TGFB1 protein; Losartan results in decreased expression of TGFB1 protein modified form
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]		 CTD PMID:11369837 PMID:12930639 PMID:12937228 PMID:15331931 PMID:15573910 More... NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression		 EXP Losartan inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP1 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP1 mRNA] CTD PMID:20137537 PMID:25233898 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression
multiple interactions		 EXP Losartan results in decreased expression of TIMP2 mRNA
Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP2 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP2 mRNA]		 CTD PMID:20137537 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Losartan results in decreased expression of TJP1 protein CTD PMID:18400868 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnc tenascin C decreases expression EXP
ISO		 Losartan results in decreased expression of TNC mRNA CTD PMID:15100363 PMID:32947957 NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 Losartan affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; T 0070907 inhibits the reaction [Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
[Losartan co-treated with Vitamin D] inhibits the reaction [Amiodarone results in increased expression of TNF protein]; Losartan inhibits the reaction [Amiodarone results in increased expression of TNF protein]; Losartan inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Losartan inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]; Losartan inhibits the reaction [Testosterone results in increased expression of TNF protein]
Losartan results in decreased expression of TNF protein
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]		 CTD PMID:15573910 PMID:17299153 PMID:18060435 PMID:22124178 PMID:23875703 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 decreases expression EXP Losartan results in decreased expression of TOMM20 mRNA CTD PMID:18765277 NCBI chr19:71,822,429...71,832,420
Ensembl chr19:54,923,402...54,935,198 		JBrowse link
G Tp53 tumor protein p53 affects expression EXP Losartan affects the expression of TP53 protein CTD PMID:22000973 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA] CTD PMID:26464165 NCBI chr15:58,159,612...58,260,244
Ensembl chr15:51,749,510...51,850,958 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein] CTD PMID:28578904 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Ucp2 uncoupling protein 2 decreases expression
multiple interactions		 ISO
EXP		 Losartan results in decreased expression of UCP2 mRNA; Losartan results in decreased expression of UCP2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]		 CTD PMID:17508912 PMID:19109942 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA] CTD PMID:19109942 NCBI chr 1:164,227,910...164,240,893
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of VCAM1 protein] CTD PMID:19553526 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO
EXP		 Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]
Losartan results in decreased expression of VEGFA mRNA; Losartan results in decreased expression of VEGFA protein
Losartan inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]		 CTD PMID:12110003 PMID:17299153 PMID:17481528 PMID:22188725 PMID:25511041 More... NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO Losartan results in decreased expression of VEGFC mRNA CTD PMID:19771429 NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
G Vim vimentin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]
Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]		 CTD PMID:28578904 PMID:33007385 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Wnt1 Wnt family member 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein] CTD PMID:28578904 NCBI chr 7:131,817,558...131,821,605
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
G Wt1 WT1 transcription factor multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein] CTD PMID:28578904 NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:91,567,001...91,613,643 		JBrowse link
losartan carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO losartan carboxylic acid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        pharmaceutical 19534
          drug 19534
            cardiovascular drug 8737
              antihypertensive agent 1948
                losartan 178
                  losartan carboxylic acid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            organic molecule 19713
                              organic cyclic compound 19505
                                organic heterocyclic compound 18875
                                  heteroarene 17153
                                    monocyclic heteroarene 15001
                                      azole 14501
                                        diazole 10771
                                          imidazoles 10221
                                            losartan 178
                                              losartan carboxylic acid 1
paths to the root