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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ifosfamide
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Accession:CHEBI:5864 term browser browse the term
Definition:The simplest member of the class of ifosfamides that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by 2-chloroethyl groups on both the nitrogen atoms respectively. It is a nitrogen mustard alkylating agent used in the treatment of advanced breast cancer.
Synonyms:exact_synonym: N,3-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
 related_synonym: 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide;   Formula=C7H15Cl2N2O2P;   InChI=1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12);   InChIKey=HOMGKSMUEGBAAB-UHFFFAOYSA-N;   Iphosphamide;   Isofosfamide;   Isophosphamide;   SMILES=ClCCNP1(=O)OCCCN1CCCl;   ifosfamida;   ifosfamidum;   isosfamide
 alt_id: CHEBI:219640
 xref: Beilstein:611835;   CAS:3778-73-2;   DrugBank:DB01181;   Drug_Central:1421;   HMDB:HMDB0015312;   KEGG:C07047;   KEGG:D00343;   LINCS:LSM-5118
 xref_mesh: MESH:D007069
 xref: PMID:11550152;   PMID:11669554;   Reaxys:5802893;   Wikipedia:Ifosfamide


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ifosfamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions		 ISO Ifosfamide results in increased expression of ABCB1 protein
[Ifosfamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; NR1I2 protein promotes the reaction [Ifosfamide results in increased expression of ABCB1 protein]		 CTD PMID:20041327 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 increases expression ISO Ifosfamide results in increased expression of ABCB6 mRNA CTD PMID:25596134 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924 		JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 increases expression ISO Ifosfamide results in increased expression of ABCB9 mRNA CTD PMID:25596134 NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Ifosfamide results in decreased expression of ABCG1 mRNA CTD PMID:25596134 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO Ifosfamide results in increased expression of ABHD4 mRNA CTD PMID:25596134 NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966 		JBrowse link
G Ache acetylcholinesterase increases activity
multiple interactions		 EXP Ifosfamide results in increased activity of ACHE protein
morin inhibits the reaction [Ifosfamide results in increased activity of ACHE protein]		 CTD PMID:31722249 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Ifosfamide results in decreased expression of ACSL1 mRNA CTD PMID:25596134 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Agrn agrin increases expression ISO Ifosfamide results in increased expression of AGRN mRNA CTD PMID:25596134 NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003 		JBrowse link
G Ahr aryl hydrocarbon receptor affects activity ISO Ifosfamide affects the activity of AHR protein CTD PMID:25596134 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ak4 adenylate kinase 4 increases expression ISO Ifosfamide results in increased expression of AK4 mRNA CTD PMID:25596134 NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Ifosfamide results in increased expression of AKR1C2 mRNA CTD PMID:25596134 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO Ifosfamide results in increased expression of ALDH1A3 mRNA CTD PMID:25596134 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO Ifosfamide results in increased expression of ALDOA mRNA CTD PMID:25596134 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182 		JBrowse link
G Als2cl ALS2 C-terminal like affects expression ISO Ifosfamide affects the expression of ALS2CL mRNA CTD PMID:25596134 NCBI chr 8:110,863,753...110,884,434
Ensembl chr 8:110,864,975...110,884,419 		JBrowse link
G Ankra2 ankyrin repeat family A member 2 decreases expression ISO Ifosfamide results in decreased expression of ANKRA2 mRNA CTD PMID:25596134 NCBI chr 2:29,612,867...29,623,748
Ensembl chr 2:29,612,925...29,623,730 		JBrowse link
G Arhgef10 Rho guanine nucleotide exchange factor 10 affects expression ISO Ifosfamide affects the expression of ARHGEF10 mRNA CTD PMID:25596134 NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173 		JBrowse link
G Arln allregulin decreases expression ISO Ifosfamide results in decreased expression of ARLN mRNA CTD PMID:25596134 NCBI chr 2:211,055,925...211,057,685
Ensembl chr 2:211,055,911...211,057,681 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Ifosfamide results in increased expression of ASNS mRNA CTD PMID:25596134 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Atf4 activating transcription factor 4 affects activity ISO Ifosfamide affects the activity of ATF4 protein CTD PMID:25596134 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atosa atos homolog A decreases expression ISO Ifosfamide results in decreased expression of ATOSA mRNA CTD PMID:25596134 NCBI chr 8:75,694,828...75,772,565
Ensembl chr 8:75,695,022...75,772,549 		JBrowse link
G Atxn1 ataxin 1 decreases expression ISO Ifosfamide results in decreased expression of ATXN1 mRNA CTD PMID:25596134 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360 		JBrowse link
G Aurkb aurora kinase B increases expression ISO Ifosfamide results in increased expression of AURKB mRNA CTD PMID:25596134 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Avp arginine vasopressin multiple interactions ISO [Ifosfamide co-treated with Mesna] results in increased expression of AVP protein CTD PMID:2261371 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Ifosfamide results in increased expression of AXL mRNA CTD PMID:25596134 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G B2m beta-2 microglobulin increases expression ISO Ifosfamide results in increased expression of B2M protein CTD PMID:8625085 PMID:9261752 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Ifosfamide results in increased expression of BAX mRNA CTD PMID:25596134 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcat1 branched chain amino acid transaminase 1 decreases expression ISO Ifosfamide results in decreased expression of BCAT1 mRNA CTD PMID:25596134 NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597 		JBrowse link
G Bche butyrylcholinesterase increases activity
multiple interactions		 EXP Ifosfamide results in increased activity of BCHE protein
morin inhibits the reaction [Ifosfamide results in increased activity of BCHE protein]		 CTD PMID:31722249 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO
EXP		 BCL2 protein inhibits the reaction [Ifosfamide results in increased activity of CASP9 protein]
Ifosfamide results in decreased expression of BCL2 mRNA
Carnitine inhibits the reaction [Ifosfamide results in decreased expression of BCL2 mRNA]; morin inhibits the reaction [Ifosfamide results in decreased expression of BCL2 mRNA]		 CTD PMID:11723234 PMID:23213347 PMID:31722249 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression		 EXP morin inhibits the reaction [Ifosfamide results in increased expression of BDNF mRNA] CTD PMID:31722249 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression ISO Ifosfamide results in decreased expression of BGLAP protein CTD PMID:1525342 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression ISO Ifosfamide results in increased expression of BHLHE40 mRNA CTD PMID:25596134 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774 		JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO Ifosfamide results in decreased expression of BNIP3 mRNA CTD PMID:25596134 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Brd2 bromodomain containing 2 decreases expression ISO Ifosfamide results in decreased expression of BRD2 mRNA CTD PMID:25596134 NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Ifosfamide results in increased expression of BTG2 mRNA CTD PMID:25596134 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G C15h8orf58 similar to human chromosome 8 open reading frame 58 increases expression ISO Ifosfamide results in increased expression of C8ORF58 mRNA CTD PMID:25596134 NCBI chr15:45,228,615...45,235,274
Ensembl chr15:45,228,615...45,233,254 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 increases expression ISO Ifosfamide results in increased expression of CAMKK2 mRNA CTD PMID:25596134 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279 		JBrowse link
G Cars1 cysteinyl-tRNA synthetase 1 decreases expression ISO Ifosfamide results in decreased expression of CARS1 mRNA CTD PMID:25596134 NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941 		JBrowse link
G Casp1 caspase 1 increases response to substance ISO CASP1 results in increased susceptibility to Ifosfamide CTD PMID:9491796 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 EXP Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP3 mRNA]; morin inhibits the reaction [Ifosfamide results in increased activity of CASP3 protein] CTD PMID:23213347 PMID:31722249 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 ISO
EXP		 BCL2 protein inhibits the reaction [Ifosfamide results in increased activity of CASP9 protein]
Ifosfamide results in increased expression of CASP9 mRNA
Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP9 mRNA]		 CTD PMID:11723234 PMID:23213347 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
decreases expression
decreases activity		 EXP Carnitine inhibits the reaction [Ifosfamide results in decreased expression of CAT mRNA]; morin inhibits the reaction [Ifosfamide results in decreased activity of CAT protein] CTD PMID:23213347 PMID:31722249 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccdc90b coiled-coil domain containing 90B decreases expression ISO Ifosfamide results in decreased expression of CCDC90B mRNA CTD PMID:25596134 NCBI chr 1:146,632,756...146,646,314
Ensembl chr 1:146,633,036...146,647,338 		JBrowse link
G Ccne2 cyclin E2 increases expression ISO Ifosfamide results in increased expression of CCNE2 mRNA CTD PMID:25596134 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Ccng2 cyclin G2 decreases expression ISO Ifosfamide results in decreased expression of CCNG2 mRNA CTD PMID:25596134 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Cda cytidine deaminase multiple interactions EXP [CYP2B1 co-treated with CDA] results in increased susceptibility to [Ifosfamide co-treated with Fluorouracil]; [CYP2B1 co-treated with CDA] results in increased susceptibility to Ifosfamide CTD PMID:10811482 NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 affects expression ISO Ifosfamide affects the expression of CDK6 mRNA CTD PMID:25596134 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Ifosfamide results in increased expression of CDKN1A mRNA CTD PMID:25596134 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cers5 ceramide synthase 5 increases expression ISO Ifosfamide results in increased expression of CERS5 mRNA CTD PMID:25596134 NCBI chr 7:130,859,993...130,897,979
Ensembl chr 7:130,859,990...130,897,947 		JBrowse link
G Cmbl carboxymethylenebutenolidase homolog increases expression ISO Ifosfamide results in increased expression of CMBL mRNA CTD PMID:25596134 NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009 		JBrowse link
G Ctdp1 CTD phosphatase subunit 1 decreases expression ISO Ifosfamide results in decreased expression of CTDP1 mRNA CTD PMID:25596134 NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457 		JBrowse link
G Cth cystathionine gamma-lyase affects expression ISO Ifosfamide affects the expression of CTH mRNA CTD PMID:25596134 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Ctsc cathepsin C increases expression ISO Ifosfamide results in increased expression of CTSC mRNA CTD PMID:25596134 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Cttn cortactin increases expression ISO Ifosfamide results in increased expression of CTTN mRNA CTD PMID:25596134 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases response to substance
decreases expression		 ISO CYP1A1 protein results in increased susceptibility to Ifosfamide
Ifosfamide results in decreased expression of CYP1A1 mRNA		 CTD PMID:20507880 PMID:25596134 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Ifosfamide results in increased expression of CYP1A2 mRNA CTD PMID:25596134 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO Ifosfamide results in decreased expression of CYP1B1 mRNA CTD PMID:25596134 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases hydroxylation
increases metabolic processing
increases activity
increases response to substance		 EXP [CYP2B1 co-treated with CDA] results in increased susceptibility to [Ifosfamide co-treated with Fluorouracil]; [CYP2B1 co-treated with CDA] results in increased susceptibility to Ifosfamide; Metyrapone inhibits the reaction [CYP2B1 results in increased susceptibility to Ifosfamide]; Mitomycin affects the reaction [CYP2B1 results in increased susceptibility to Ifosfamide]
CYP2B1 protein mutant form results in increased hydroxylation of Ifosfamide
CYP2B1 protein results in increased metabolism of Ifosfamide; CYP2B1 results in increased metabolism of Ifosfamide
CYP2B1 results in increased activity of Ifosfamide		 CTD PMID:2272335 PMID:7834628 PMID:8640822 PMID:9592392 PMID:10415877 More... NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases response to substance
multiple interactions
affects metabolic processing		 ISO CYP2B6 results in increased susceptibility to Ifosfamide
POR promotes the reaction [CYP2B6 results in increased susceptibility to Ifosfamide]
CYP2B6 protein affects the metabolism of Ifosfamide		 CTD PMID:9766669 PMID:15875221 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases activity
increases response to substance
multiple interactions
increases metabolic processing		 ISO CYP2C18 results in increased activity of Ifosfamide
CYP2C18 results in increased susceptibility to Ifosfamide
POR promotes the reaction [CYP2C18 results in increased susceptibility to Ifosfamide]
CYP2C18 results in increased metabolism of Ifosfamide		 CTD PMID:9241661 PMID:9766669 PMID:15301741 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases response to substance
increases activity		 ISO CYP2C19 protein results in increased susceptibility to Ifosfamide
CYP2C19 results in increased activity of Ifosfamide		 CTD PMID:9241661 PMID:20507880 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases activity ISO CYP2C8 results in increased activity of Ifosfamide CTD PMID:9241661
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases response to substance ISO CYP2D6 protein results in increased susceptibility to Ifosfamide CTD PMID:20507880 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
decreases ethylation
affects degradation
increases response to substance
affects metabolic processing
affects hydroxylation		 ISO Ifosfamide results in increased expression of CYP3A4 mRNA
CYP3A4 gene mutant form results in decreased ethylation of Ifosfamide; CYP3A4 protein results in decreased ethylation of Ifosfamide
CYP3A4 protein affects the degradation of Ifosfamide
CYP3A4 protein results in increased susceptibility to Ifosfamide; CYP3A4 results in increased susceptibility to Ifosfamide
CYP3A4 protein affects the metabolism of Ifosfamide
CYP3A4 protein affects the hydroxylation of Ifosfamide		 CTD PMID:9766669 PMID:12136253 PMID:15821045 PMID:15875221 PMID:18839173 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases hydroxylation EXP CYP3A23-3A1 protein results in increased hydroxylation of Ifosfamide CTD PMID:15919850 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing
decreases ethylation		 ISO CYP3A5 protein affects the metabolism of Ifosfamide
CYP3A5 protein results in decreased ethylation of Ifosfamide		 CTD PMID:15821045 PMID:15875221 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Ifosfamide results in increased expression of DDIT3 mRNA CTD PMID:25596134 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Ifosfamide results in increased expression of DDIT4 mRNA CTD PMID:25596134 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Ddx17 DEAD-box helicase 17 decreases expression ISO Ifosfamide results in decreased expression of DDX17 mRNA CTD PMID:25596134 NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193 		JBrowse link
G Dgka diacylglycerol kinase, alpha increases expression ISO Ifosfamide results in increased expression of DGKA mRNA CTD PMID:25596134 NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110 		JBrowse link
G Dlx1 distal-less homeobox 1 decreases expression ISO Ifosfamide results in decreased expression of DLX1 mRNA CTD PMID:25596134 NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780 		JBrowse link
G Dnai3 dynein axonemal intermediate chain 3 decreases expression ISO Ifosfamide results in decreased expression of DNAI3 mRNA CTD PMID:25596134 NCBI chr 2:234,947,910...235,006,173
Ensembl chr 2:234,929,677...235,006,173 		JBrowse link
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 increases expression ISO Ifosfamide results in increased expression of DNAJB2 mRNA CTD PMID:25596134 NCBI chr 9:76,731,060...76,739,278
Ensembl chr 9:76,731,065...76,739,277 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Ifosfamide results in increased expression of DNAJB9 mRNA CTD PMID:25596134 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063 		JBrowse link
G Dnmbp dynamin binding protein increases expression ISO Ifosfamide results in increased expression of DNMBP mRNA CTD PMID:25596134 NCBI chr 1:242,736,189...242,829,431
Ensembl chr 1:242,736,189...242,802,604 		JBrowse link
G Dpm3 dolichyl-phosphate mannosyltransferase subunit 3, regulatory increases expression ISO Ifosfamide results in increased expression of DPM3 mRNA CTD PMID:25596134 NCBI chr 2:174,676,532...174,677,047
Ensembl chr 2:174,676,363...174,677,668
Ensembl chr15:174,676,363...174,677,668 		JBrowse link
G Dusp22 dual specificity phosphatase 22 increases expression ISO Ifosfamide results in increased expression of DUSP22 mRNA CTD PMID:25596134 NCBI chr17:33,780,980...33,831,241
Ensembl chr17:33,780,981...33,831,321 		JBrowse link
G Efna1 ephrin A1 decreases expression ISO Ifosfamide results in decreased expression of EFNA1 mRNA CTD PMID:25596134 NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Eif1 eukaryotic translation initiation factor 1 increases expression ISO Ifosfamide results in increased expression of EIF1 mRNA CTD PMID:25596134 NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327 		JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C decreases expression ISO Ifosfamide results in decreased expression of EIF3C mRNA CTD PMID:25596134 NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493 		JBrowse link
G Elf4 E74 like ETS transcription factor 4 increases expression ISO Ifosfamide results in increased expression of ELF4 mRNA CTD PMID:25596134 NCBI chr  X:127,587,401...127,639,063
Ensembl chr  X:127,590,650...127,630,200 		JBrowse link
G Elk4 ETS transcription factor ELK4 decreases expression ISO Ifosfamide results in decreased expression of ELK4 mRNA CTD PMID:25596134 NCBI chr13:43,451,130...43,475,035
Ensembl chr13:43,435,843...43,475,035 		JBrowse link
G Eno2 enolase 2 increases expression ISO Ifosfamide results in increased expression of ENO2 mRNA CTD PMID:25596134 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Enosf1 enolase superfamily member 1 decreases expression ISO Ifosfamide results in decreased expression of ENOSF1 mRNA CTD PMID:25596134 NCBI chr 9:113,275,267...113,314,842 JBrowse link
G Ep400 E1A binding protein p400 decreases expression ISO Ifosfamide results in decreased expression of EP400 mRNA CTD PMID:25596134 NCBI chr12:45,891,886...46,002,523
Ensembl chr12:45,891,916...45,998,861 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO Ifosfamide results in increased expression of ERO1A mRNA CTD PMID:25596134 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478 		JBrowse link
G Exoc7 exocyst complex component 7 increases expression ISO Ifosfamide results in increased expression of EXOC7 mRNA CTD PMID:25596134 NCBI chr10:101,521,630...101,540,425
Ensembl chr10:101,520,927...101,540,561 		JBrowse link
G Fabp3 fatty acid binding protein 3 decreases expression ISO Ifosfamide results in decreased expression of FABP3 mRNA CTD PMID:25596134 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Fam162a family with sequence similarity 162, member A decreases expression ISO Ifosfamide results in decreased expression of FAM162A mRNA CTD PMID:25596134 NCBI chr11:64,680,978...64,709,865
Ensembl chr11:64,680,323...64,711,239 		JBrowse link
G Fam210b family with sequence similarity 210, member B decreases expression ISO Ifosfamide results in decreased expression of FAM210B mRNA CTD PMID:25596134 NCBI chr 3:161,118,228...161,128,400
Ensembl chr 3:161,118,239...161,128,397 		JBrowse link
G Fam89a family with sequence similarity 89, member A increases expression ISO Ifosfamide results in increased expression of FAM89A mRNA CTD PMID:25596134 NCBI chr19:52,710,002...52,722,630
Ensembl chr19:52,710,019...52,722,631 		JBrowse link
G Faslg Fas ligand increases expression ISO Ifosfamide results in increased expression of FASL CTD PMID:16453328 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fbxo22 F-box protein 22 increases expression ISO Ifosfamide results in increased expression of FBXO22 mRNA CTD PMID:25596134 NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148 		JBrowse link
G Fbxo30 F-box protein 30 decreases expression ISO Ifosfamide results in decreased expression of FBXO30 mRNA CTD PMID:25596134 NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441 		JBrowse link
G Fech ferrochelatase decreases expression ISO Ifosfamide results in decreased expression of FECH mRNA CTD PMID:25596134 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Flvcr2 FLVCR choline and putative heme transporter 2 decreases expression ISO Ifosfamide results in decreased expression of FLVCR2 mRNA CTD PMID:25596134 NCBI chr 6:105,408,355...105,472,355
Ensembl chr 6:105,408,339...105,472,353 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP morin inhibits the reaction [Ifosfamide results in increased expression of FOS protein] CTD PMID:31722249 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Ifosfamide results in increased expression of FOSL1 mRNA CTD PMID:25596134 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Gars1 glycyl-tRNA synthetase 1 increases expression ISO Ifosfamide results in increased expression of GARS1 mRNA CTD PMID:25596134 NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression ISO Ifosfamide results in decreased expression of GCLC mRNA CTD PMID:25596134 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Ifosfamide results in increased expression of GCLM mRNA CTD PMID:25596134 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Ifosfamide results in increased expression of GDF15 mRNA CTD PMID:25596134 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression
multiple interactions		 EXP Ifosfamide results in increased expression of GFAP protein
morin inhibits the reaction [Ifosfamide results in increased expression of GFAP protein]		 CTD PMID:31722249 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Ifosfamide results in increased expression of GPAT3 mRNA CTD PMID:25596134 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490 		JBrowse link
G Gpr87 G protein-coupled receptor 87 decreases expression ISO Ifosfamide results in decreased expression of GPR87 mRNA CTD PMID:25596134 NCBI chr 2:143,439,741...143,440,901
Ensembl chr 2:143,439,735...143,458,190 		JBrowse link
G Gpr88 G-protein coupled receptor 88 increases expression ISO Ifosfamide results in increased expression of GPR88 mRNA CTD PMID:25596134 NCBI chr 2:204,191,443...204,199,576
Ensembl chr 2:204,191,427...204,199,733 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
decreases expression		 EXP Carnitine inhibits the reaction [Ifosfamide results in decreased expression of GPX1 mRNA] CTD PMID:23213347 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx3 glutathione peroxidase 3 decreases activity ISO Ifosfamide results in decreased activity of GPX3 protein CTD PMID:9851889 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Ifosfamide results in increased expression of GSR mRNA CTD PMID:25596134 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects response to substance
increases response to substance		 ISO GSTP1 gene polymorphism affects the susceptibility to Ifosfamide
GSTP1 gene polymorphism results in increased susceptibility to Ifosfamide		 CTD PMID:12868187 PMID:16282887 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Herc3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 decreases expression ISO Ifosfamide results in decreased expression of HERC3 mRNA CTD PMID:25596134 NCBI chr 4:87,952,202...88,042,492
Ensembl chr 4:87,952,274...88,042,488 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects activity ISO Ifosfamide affects the activity of HIF1A protein CTD PMID:25596134 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Ifosfamide results in increased expression of HSPA1B mRNA CTD PMID:25596134 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 increases expression ISO Ifosfamide results in increased expression of IARS1 mRNA CTD PMID:25596134 NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237 		JBrowse link
G Ids iduronate 2-sulfatase decreases expression ISO Ifosfamide results in decreased expression of IDS mRNA CTD PMID:25596134 NCBI chr  X:149,025,976...149,046,641
Ensembl chr  X:149,025,976...149,046,663 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO [Ifosfamide co-treated with IFNB1] affects the expression of MMP9 mRNA; [Ifosfamide co-treated with IFNB1] affects the expression of MMP9 protein; [Ifosfamide co-treated with IFNB1] results in decreased expression of PLAUR protein; IFNB1 promotes the reaction [Ifosfamide results in decreased activity of MMP9 protein]; IFNB1 promotes the reaction [Ifosfamide results in decreased expression of VEGFA protein] CTD PMID:15659795 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor increases expression ISO Ifosfamide results in increased expression of IGF2R mRNA CTD PMID:25596134 NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501 		JBrowse link
G Il19 interleukin 19 increases secretion ISO Ifosfamide results in increased secretion of IL19 protein CTD PMID:24714768 NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473 		JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions		 EXP Ifosfamide results in increased secretion of IL1B protein
resveratrol inhibits the reaction [Ifosfamide results in increased secretion of IL1B protein]		 CTD PMID:17481685 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions		 EXP Ifosfamide results in increased secretion of IL6 protein
resveratrol inhibits the reaction [Ifosfamide results in increased secretion of IL6 protein]		 CTD PMID:17481685 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inka2 inka box actin regulator 2 increases expression ISO Ifosfamide results in increased expression of INKA2 mRNA CTD PMID:25596134 NCBI chr 2:193,185,275...193,200,643
Ensembl chr 2:193,185,275...193,200,642 		JBrowse link
G Insig2 insulin induced gene 2 increases expression ISO Ifosfamide results in increased expression of INSIG2 mRNA CTD PMID:25596134 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G Itfg2 integrin alpha FG-GAP repeat containing 2 decreases expression ISO Ifosfamide results in decreased expression of ITFG2 mRNA CTD PMID:25596134 NCBI chr 4:161,684,249...161,698,315
Ensembl chr 4:161,684,249...161,698,422 		JBrowse link
G Itgb1 integrin subunit beta 1 affects expression ISO Ifosfamide affects the expression of ITGB1 mRNA CTD PMID:25596134 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Kat6b lysine acetyltransferase 6B decreases expression ISO Ifosfamide results in decreased expression of KAT6B mRNA CTD PMID:25596134 NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316 		JBrowse link
G Kdm3a lysine demethylase 3A decreases expression ISO Ifosfamide results in decreased expression of KDM3A mRNA CTD PMID:25596134 NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Ifosfamide results in increased expression of KEAP1 mRNA CTD PMID:25596134 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Krt15 keratin 15 increases expression ISO Ifosfamide results in increased expression of KRT15 mRNA CTD PMID:25596134 NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Krt19 keratin 19 increases expression ISO Ifosfamide results in increased expression of KRT19 mRNA CTD PMID:25596134 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO Ifosfamide results in increased expression of LAMA3 mRNA CTD PMID:25596134 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 decreases expression ISO Ifosfamide results in decreased expression of LMCD1 mRNA CTD PMID:25596134 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046 		JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 decreases expression ISO Ifosfamide results in decreased expression of LTN1 mRNA CTD PMID:25596134 NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886 		JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO Ifosfamide results in increased expression of MAFG mRNA CTD PMID:25596134 NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity
multiple interactions		 EXP Ifosfamide results in increased activity of MAPK8 protein
morin inhibits the reaction [Ifosfamide results in increased activity of MAPK8 protein]		 CTD PMID:31722249 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO Ifosfamide results in increased expression of MDM2 mRNA CTD PMID:25596134 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Me1 malic enzyme 1 decreases expression ISO Ifosfamide results in decreased expression of ME1 mRNA CTD PMID:25596134 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
affects expression
decreases activity		 ISO [Ifosfamide co-treated with IFNA2] affects the expression of MMP9 mRNA; [Ifosfamide co-treated with IFNA2] affects the expression of MMP9 protein; [Ifosfamide co-treated with IFNB1] affects the expression of MMP9 mRNA; [Ifosfamide co-treated with IFNB1] affects the expression of MMP9 protein; IFNA2 promotes the reaction [Ifosfamide results in decreased activity of MMP9 protein]; IFNB1 promotes the reaction [Ifosfamide results in decreased activity of MMP9 protein]
Ifosfamide affects the expression of MMP9 mRNA		 CTD PMID:15659795 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Ifosfamide affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970 		JBrowse link
G Mt2A metallothionein 2A increases expression ISO Ifosfamide results in increased expression of MT2A mRNA CTD PMID:25596134 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mtdh metadherin decreases expression ISO Ifosfamide results in decreased expression of MTDH mRNA CTD PMID:25596134 NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413 		JBrowse link
G Mtfp1 mitochondrial fission process 1 increases expression ISO Ifosfamide results in increased expression of MTFP1 mRNA CTD PMID:25596134 NCBI chr14:78,968,434...78,972,274
Ensembl chr14:78,968,442...78,972,274 		JBrowse link
G Mxi1 MAX interactor 1, dimerization protein decreases expression ISO Ifosfamide results in decreased expression of MXI1 mRNA CTD PMID:25596134 NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681 		JBrowse link
G Ncapd2 non-SMC condensin I complex, subunit D2 increases expression ISO Ifosfamide results in increased expression of NCAPD2 mRNA CTD PMID:25596134 NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression ISO Ifosfamide results in decreased expression of NEDD9 mRNA CTD PMID:25596134 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects activity
multiple interactions
decreases expression		 ISO
EXP		 Ifosfamide affects the activity of NFE2L2 protein
morin inhibits the reaction [Ifosfamide results in decreased expression of NFE2L2 protein]		 CTD PMID:25596134 PMID:31722249 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nin ninein decreases expression ISO Ifosfamide results in decreased expression of NIN mRNA CTD PMID:25596134 NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639 		JBrowse link
G Nos1 nitric oxide synthase 1 increases activity
multiple interactions		 EXP Ifosfamide results in increased activity of NOS1 protein
morin inhibits the reaction [Ifosfamide results in increased activity of NOS1 protein]		 CTD PMID:31722249 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 EXP Carnitine inhibits the reaction [Ifosfamide results in increased expression of NOS2 mRNA] CTD PMID:23213347 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 increases expression ISO Ifosfamide results in increased expression of NPY1R mRNA CTD PMID:25596134 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression ISO Ifosfamide results in decreased expression of NQO1 mRNA CTD PMID:25596134 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO [Ifosfamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; Ifosfamide binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Ifosfamide results in increased expression of ABCB1 protein] CTD PMID:18839173 PMID:20041327 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nrep neuronal regeneration related protein affects expression ISO Ifosfamide affects the expression of NREP mRNA CTD PMID:25596134 NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591 		JBrowse link
G Ntpcr nucleoside-triphosphatase, cancer-related increases expression ISO Ifosfamide results in increased expression of NTPCR mRNA CTD PMID:25596134 NCBI chr19:53,701,496...53,715,260
Ensembl chr19:53,695,976...53,715,202 		JBrowse link
G Nuak1 NUAK family kinase 1 decreases expression ISO Ifosfamide results in decreased expression of NUAK1 mRNA CTD PMID:25596134 NCBI chr 7:19,330,034...19,401,918
Ensembl chr 7:19,329,933...19,401,913 		JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 decreases expression ISO Ifosfamide results in decreased expression of OSGIN1 mRNA CTD PMID:25596134 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516 		JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 decreases expression ISO Ifosfamide results in decreased expression of P4HA1 mRNA CTD PMID:25596134 NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786 		JBrowse link
G Pank1 pantothenate kinase 1 decreases expression ISO Ifosfamide results in decreased expression of PANK1 mRNA CTD PMID:25596134 NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:232,328,430...232,396,829 		JBrowse link
G Pde8a phosphodiesterase 8A decreases expression ISO Ifosfamide results in decreased expression of PDE8A mRNA CTD PMID:25596134 NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024 		JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 increases expression ISO Ifosfamide results in increased expression of PDIA5 mRNA CTD PMID:25596134 NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO Ifosfamide results in decreased expression of PDK1 mRNA CTD PMID:25596134 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression ISO Ifosfamide results in increased expression of PHGDH mRNA CTD PMID:25596134 NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO Ifosfamide results in increased expression of PHLDA3 mRNA CTD PMID:25596134 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Pidd1 p53-induced death domain protein 1 decreases expression ISO Ifosfamide results in decreased expression of PIDD1 mRNA CTD PMID:25596134 NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699 		JBrowse link
G Plaur plasminogen activator, urokinase receptor affects expression
multiple interactions		 ISO Ifosfamide affects the expression of PLAUR protein
[Ifosfamide co-treated with IFNA2] results in decreased expression of PLAUR protein; [Ifosfamide co-treated with IFNB1] results in decreased expression of PLAUR protein		 CTD PMID:15659795 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 increases expression ISO Ifosfamide results in increased expression of PMEPA1 mRNA CTD PMID:25596134 NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454 		JBrowse link
G Podxl podocalyxin-like decreases expression ISO Ifosfamide results in decreased expression of PODXL mRNA CTD PMID:25596134 NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO POR promotes the reaction [CYP2B6 results in increased susceptibility to Ifosfamide]; POR promotes the reaction [CYP2C18 results in increased susceptibility to Ifosfamide] CTD PMID:9766669 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects activity ISO Ifosfamide affects the activity of PPARG protein CTD PMID:25596134 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppfibp1 PPFIA binding protein 1 increases expression ISO Ifosfamide results in increased expression of PPFIBP1 mRNA CTD PMID:25596134 NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428 		JBrowse link
G Ppig peptidylprolyl isomerase G decreases expression ISO Ifosfamide results in decreased expression of PPIG mRNA CTD PMID:25596134 NCBI chr 3:54,484,023...54,512,929
Ensembl chr 3:54,484,023...54,512,926 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D decreases expression ISO Ifosfamide results in decreased expression of PPM1D mRNA CTD PMID:25596134 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression ISO Ifosfamide results in increased expression of PRC1 mRNA CTD PMID:25596134 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765 		JBrowse link
G Prdm1 PR/SET domain 1 decreases expression ISO Ifosfamide results in decreased expression of PRDM1 mRNA CTD PMID:25596134 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 affects expression ISO Ifosfamide affects the expression of PRKAB1 mRNA CTD PMID:25596134 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661 		JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 affects expression ISO Ifosfamide affects the expression of PRKAB2 mRNA CTD PMID:25596134 NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO Ifosfamide results in increased expression of PSAT1 mRNA CTD PMID:25596134 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682 		JBrowse link
G Pspc1 paraspeckle component 1 decreases expression ISO Ifosfamide results in decreased expression of PSPC1 mRNA CTD PMID:25596134 NCBI chr15:30,828,617...30,911,315
Ensembl chr15:30,828,626...30,911,202 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP etoricoxib inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]; Indomethacin inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]; Pentoxifylline inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]; Thalidomide inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein] CTD PMID:17638016 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 increases expression ISO Ifosfamide results in increased expression of PYCR1 mRNA CTD PMID:25596134 NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549 		JBrowse link
G Pygl glycogen phosphorylase L decreases expression ISO Ifosfamide results in decreased expression of PYGL mRNA CTD PMID:25596134 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310 		JBrowse link
G Rab31 RAB31, member RAS oncogene family increases expression ISO Ifosfamide results in increased expression of RAB31 mRNA CTD PMID:25596134 NCBI chr 9:105,246,712...105,382,973
Ensembl chr 9:105,246,709...105,381,253 		JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase increases expression ISO Ifosfamide results in increased expression of RFFL mRNA CTD PMID:25596134 NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434 		JBrowse link
G Rit1 Ras-like without CAAX 1 increases expression ISO Ifosfamide results in increased expression of RIT1 mRNA CTD PMID:25596134 NCBI chr 2:174,180,742...174,195,455
Ensembl chr 2:174,180,848...174,195,455 		JBrowse link
G Rlf RLF zinc finger increases expression ISO Ifosfamide results in increased expression of RLF mRNA CTD PMID:25596134 NCBI chr 5:134,711,612...134,767,274
Ensembl chr 5:134,711,619...134,767,257 		JBrowse link
G Rnf121 ring finger protein 121 decreases expression ISO Ifosfamide results in decreased expression of RNF121 mRNA CTD PMID:25596134 NCBI chr 1:156,377,368...156,439,936
Ensembl chr 1:156,377,364...156,446,826 		JBrowse link
G Ro60 Ro60, Y RNA binding protein decreases expression ISO Ifosfamide results in decreased expression of RO60 mRNA CTD PMID:25596134 NCBI chr13:55,499,514...55,520,504
Ensembl chr13:55,499,534...55,520,504 		JBrowse link
G Rps27l ribosomal protein S27-like increases expression ISO Ifosfamide results in increased expression of RPS27L mRNA CTD PMID:25596134 NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B decreases expression ISO Ifosfamide results in decreased expression of RRM2B mRNA CTD PMID:25596134 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Rrp12 ribosomal RNA processing 12 increases expression ISO Ifosfamide results in increased expression of RRP12 mRNA CTD PMID:25596134 NCBI chr 1:240,672,378...240,705,992
Ensembl chr 1:240,672,382...240,706,018 		JBrowse link
G Rsrc2 arginine and serine rich coiled-coil 2 decreases expression ISO Ifosfamide results in decreased expression of RSRC2 mRNA CTD PMID:25596134 NCBI chr12:32,839,840...32,859,820
Ensembl chr12:32,839,809...32,859,799 		JBrowse link
G RT1-CE16 RT1 class I, locus CE16 affects expression ISO Ifosfamide affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Ifosfamide affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Sars1 seryl-tRNA synthetase 1 increases expression ISO Ifosfamide results in increased expression of SARS1 mRNA CTD PMID:25596134 NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277 		JBrowse link
G Sertad1 SERTA domain containing 1 increases expression ISO Ifosfamide results in increased expression of SERTAD1 mRNA CTD PMID:25596134 NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091 		JBrowse link
G Sesn1 sestrin 1 increases expression ISO Ifosfamide results in increased expression of SESN1 mRNA CTD PMID:25596134 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697 		JBrowse link
G Sfn stratifin increases expression ISO Ifosfamide results in increased expression of SFN mRNA CTD PMID:25596134 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sh3tc1 SH3 domain and tetratricopeptide repeats 1 decreases expression ISO Ifosfamide results in decreased expression of SH3TC1 mRNA CTD PMID:25596134 NCBI chr14:75,005,691...75,050,001
Ensembl chr14:75,016,875...75,049,995 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 increases expression ISO Ifosfamide results in increased expression of SIAH2 mRNA CTD PMID:25596134 NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950 		JBrowse link
G Sipa1l2 signal-induced proliferation-associated 1 like 2 decreases expression ISO Ifosfamide results in decreased expression of SIPA1L2 mRNA CTD PMID:25596134 NCBI chr19:53,389,792...53,540,466
Ensembl chr19:53,389,805...53,540,428 		JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor increases expression ISO Ifosfamide results in increased expression of SIVA1 mRNA CTD PMID:25596134 NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690 		JBrowse link
G Slc12a8 solute carrier family 12, member 8 decreases expression ISO Ifosfamide results in decreased expression of SLC12A8 mRNA CTD PMID:25596134 NCBI chr11:67,116,876...67,266,548
Ensembl chr11:67,116,877...67,266,834 		JBrowse link
G Slc1a5 solute carrier family 1 member 5 increases expression ISO Ifosfamide results in increased expression of SLC1A5 mRNA CTD PMID:25596134 NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 decreases expression EXP Ifosfamide results in decreased expression of SLC22A5 mRNA; Ifosfamide results in decreased expression of SLC22A5 protein CTD PMID:22701146 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 increases expression ISO Ifosfamide results in increased expression of SLC25A20 mRNA CTD PMID:25596134 NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Ifosfamide results in increased expression of SLC2A1 mRNA CTD PMID:25596134 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO Ifosfamide results in increased expression of SLC3A2 mRNA CTD PMID:25596134 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression ISO Ifosfamide results in decreased expression of SLC6A9 mRNA CTD PMID:25596134 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO Ifosfamide results in increased expression of SLC7A5 mRNA CTD PMID:25596134 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Son SON DNA and RNA binding protein decreases expression ISO Ifosfamide results in decreased expression of SON mRNA CTD PMID:25596134 NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167 		JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 increases expression ISO Ifosfamide results in increased expression of SPSB1 mRNA CTD PMID:25596134 NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Ifosfamide results in increased expression of SQSTM1 mRNA CTD PMID:25596134 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srd5a3 steroid 5 alpha-reductase 3 decreases expression ISO Ifosfamide results in decreased expression of SRD5A3 mRNA CTD PMID:25596134 NCBI chr14:32,046,408...32,060,796
Ensembl chr14:32,046,408...32,060,747 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Ifosfamide results in increased expression of SRXN1 mRNA CTD PMID:25596134 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Sulf2 sulfatase 2 decreases expression ISO Ifosfamide results in decreased expression of SULF2 mRNA CTD PMID:25596134 NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415 		JBrowse link
G Taldo1 transaldolase 1 increases expression ISO Ifosfamide results in increased expression of TALDO1 mRNA CTD PMID:25596134 NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974 		JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases expression ISO Ifosfamide results in decreased expression of TARS1 mRNA CTD PMID:25596134 NCBI chr 2:60,368,893...60,387,715
Ensembl chr 2:60,367,796...60,387,717 		JBrowse link
G Tbxas1 thromboxane A synthase 1 increases expression ISO Ifosfamide results in increased expression of TBXAS1 mRNA CTD PMID:25596134 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
G Tfap2a transcription factor AP-2 alpha decreases expression ISO Ifosfamide results in decreased expression of TFAP2A mRNA CTD PMID:25596134 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Thbs2 thrombospondin 2 decreases expression ISO Ifosfamide results in decreased expression of THBS2 mRNA CTD PMID:25596134 NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase increases expression ISO Ifosfamide results in increased expression of TIGAR mRNA CTD PMID:25596134 NCBI chr 4:159,927,136...159,946,077
Ensembl chr 4:159,927,139...159,946,029 		JBrowse link
G Timm17b translocase of inner mitochondrial membrane 17b decreases expression ISO Ifosfamide results in decreased expression of TIMM17B mRNA CTD PMID:25596134 NCBI chr  X:14,596,330...14,603,491
Ensembl chr  X:14,594,577...14,603,416 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression ISO Ifosfamide results in increased expression of TLR4 mRNA CTD PMID:25596134 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tmem94 transmembrane protein 94 decreases expression ISO Ifosfamide results in decreased expression of TMEM94 mRNA CTD PMID:25596134 NCBI chr10:100,991,523...101,027,046
Ensembl chr10:100,991,573...101,027,394 		JBrowse link
G Tmtc2 transmembrane O-mannosyltransferase targeting cadherins 2 decreases expression ISO Ifosfamide results in decreased expression of TMTC2 mRNA CTD PMID:25596134 NCBI chr 7:40,392,377...40,806,685
Ensembl chr 7:40,394,220...40,807,298 		JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
increases expression		 EXP Ifosfamide results in increased secretion of TNF protein
morin inhibits the reaction [Ifosfamide results in increased expression of TNF protein]; Resveratrol inhibits the reaction [Ifosfamide results in increased secretion of TNF protein]		 CTD PMID:17481685 PMID:31722249 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip8 TNF alpha induced protein 8 increases expression ISO Ifosfamide results in increased expression of TNFAIP8 mRNA CTD PMID:25596134 NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517 		JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO Ifosfamide results in increased expression of TNFSF9 mRNA CTD PMID:25596134 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
G Top1 DNA topoisomerase I increases expression ISO Ifosfamide results in increased expression of TOP1 mRNA CTD PMID:25596134 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623 		JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide] CTD PMID:11325482 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tp53 tumor protein p53 affects activity
increases expression
multiple interactions		 ISO
EXP		 Ifosfamide affects the activity of TP53 protein
Ifosfamide results in increased expression of TP53 protein
morin inhibits the reaction [Ifosfamide results in increased expression of TP53 protein]		 CTD PMID:25596134 PMID:31722249 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Ifosfamide results in increased expression of TP53I3 mRNA CTD PMID:25596134 NCBI chr 6:27,818,327...27,825,753 JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO Ifosfamide results in increased expression of TP53INP1 mRNA CTD PMID:25596134 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968 		JBrowse link
G Trafd1 TRAF type zinc finger domain containing 1 increases expression ISO Ifosfamide results in increased expression of TRAFD1 mRNA CTD PMID:25596134 NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 increases expression ISO Ifosfamide results in increased expression of TRIAP1 mRNA CTD PMID:25596134 NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042 		JBrowse link
G Tspan12 tetraspanin 12 decreases expression ISO Ifosfamide results in decreased expression of TSPAN12 mRNA CTD PMID:25596134 NCBI chr 4:50,313,768...50,389,246
Ensembl chr 4:50,313,772...50,389,246 		JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Ifosfamide results in increased expression of TXN mRNA CTD PMID:25596134 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Ifosfamide results in increased expression of TXNRD1 mRNA CTD PMID:25596134 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 increases expression ISO Ifosfamide results in increased expression of UBE2G2 mRNA CTD PMID:25596134 NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447 		JBrowse link
G Unkl unk like zinc finger increases expression ISO Ifosfamide results in increased expression of UNKL mRNA CTD PMID:25596134 NCBI chr10:14,206,125...14,252,226
Ensembl chr10:14,206,189...14,252,225 		JBrowse link
G Usp3 ubiquitin specific peptidase 3 increases expression ISO Ifosfamide results in increased expression of USP3 mRNA CTD PMID:25596134 NCBI chr 8:67,078,249...67,154,109
Ensembl chr 8:67,079,927...67,154,111 		JBrowse link
G Vars1 valyl-tRNA synthetase 1 increases expression ISO Ifosfamide results in increased expression of VARS1 mRNA CTD PMID:25596134 NCBI chr20:3,805,774...3,820,468
Ensembl chr20:3,805,776...3,820,298 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO IFNA2 promotes the reaction [Ifosfamide results in decreased expression of VEGFA protein]; IFNB1 promotes the reaction [Ifosfamide results in decreased expression of VEGFA protein] CTD PMID:15659795 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO Ifosfamide results in increased expression of WARS1 mRNA CTD PMID:25596134 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269 		JBrowse link
G Wwc2 WW and C2 domain containing 2 decreases expression ISO Ifosfamide results in decreased expression of WWC2 mRNA CTD PMID:25596134 NCBI chr16:44,258,372...44,421,815
Ensembl chr16:44,258,372...44,421,812 		JBrowse link
G Xbp1 X-box binding protein 1 affects activity ISO Ifosfamide affects the activity of XBP1 protein CTD PMID:25596134 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor increases expression ISO Ifosfamide results in increased expression of XPC mRNA CTD PMID:25596134 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
G Yeats2 YEATS domain containing 2 affects expression ISO Ifosfamide affects the expression of YEATS2 mRNA CTD PMID:25596134 NCBI chr11:80,743,134...80,829,253
Ensembl chr11:80,743,134...80,829,208 		JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO Ifosfamide results in increased expression of ZMAT3 mRNA CTD PMID:25596134 NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      biological role 19858
        xenobiotic 18739
          ifosfamide 248
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      chalcogen 19577
                        oxygen atom 19549
                          oxygen molecular entity 19529
                            hydroxides 19334
                              oxoacid 18791
                                pnictogen oxoacid 14973
                                  phosphorus oxoacid 14576
                                    phosphoric acids 13937
                                      phosphoric acid 13926
                                        phosphoramide 1086
                                          phosphorodiamide 1033
                                            ifosfamides 248
                                              ifosfamide 248
paths to the root