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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619934
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c6
Name: cytochrome P450, family 2, subfamily C, polypeptide 6
Acc ID: CHEBI:5864
Term: ifosfamide
Definition: The simplest member of the class of ifosfamides that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by 2-chloroethyl groups on both the nitrogen atoms respectively. It is a nitrogen mustard alkylating agent used in the treatment of advanced breast cancer.
Chemical ID: MESH:D007069
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c6increases activityISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 results in increased activity of IfosfamidePMID:9241661
Cyp2c6increases response to substanceISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein results in increased susceptibility to IfosfamidePMID:20507880
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