zidovudine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	zidovudine	go back to main search page
Accession:	CHEBI:10110	browse the term
Definition:	A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.
Synonyms:	related_synonym:	3'-Azido-3'-deoxythymidine; AZT; Azidothymidine; Formula=C10H13N5O4; InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1; InChIKey=HBOMLICNUCNMMY-XLPZGREQSA-N; Retrovir; SMILES=Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O; Zidovudin; Zidovudinum
	alt_id:	CHEBI:619601
	xref:	Beilstein:763034; CAS:30516-87-1; DrugBank:DB00495; Drug_Central:2861; KEGG:C07210; KEGG:D00413; LINCS:LSM-5806
	xref_mesh:	MESH:D015215
	xref:	MetaCyc:CPD-15110; PDBeChem:AZZ; PMID:19112024; PMID:26859826; PMID:29438107; PMID:9203666; Patent:US4724232; Wikipedia:Zidovudine

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Genes (535)

zidovudine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 3

increases expression

Zidovudine results in increased expression of ABCA3 mRNA

NCBI chr16:2,275,881...2,340,728
Ensembl chr16:2,275,881...2,340,746

G

ATP binding cassette subfamily A member 7

decreases expression
increases expression

Zidovudine results in decreased expression of ABCA7 mRNA
Zidovudine results in increased expression of ABCA7 mRNA

NCBI chr19:1,040,107...1,065,572
Ensembl chr19:1,039,997...1,065,572

G

ATP binding cassette subfamily B member 1

increases expression

Zidovudine results in increased expression of ABCB1 mRNA; Zidovudine results in increased expression of ABCB1 protein

PMID:9148857 PMID:15456083 PMID:18310046 PMID:24292225

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily B member 11

decreases expression

Zidovudine results in decreased expression of ABCB11 mRNA

NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324

G

ATP binding cassette subfamily B member 9

increases expression

Zidovudine results in increased expression of ABCB9 mRNA

NCBI chr12:122,918,610...122,975,114
Ensembl chr12:122,920,951...122,981,649

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

increases expression

Zidovudine results in increased expression of ABCC1 mRNA

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

G

ATP binding cassette subfamily C member 10

increases expression

Zidovudine results in increased expression of ABCC10 mRNA

NCBI chr 6:43,427,541...43,451,994
Ensembl chr 6:43,427,366...43,450,427

G

ATP binding cassette subfamily C member 11

increases expression

Zidovudine results in increased expression of ABCC11 mRNA

NCBI chr16:48,164,819...48,247,539
Ensembl chr16:48,165,773...48,247,568

G

ATP binding cassette subfamily C member 3

increases expression
decreases expression

Zidovudine results in increased expression of ABCC3 mRNA
Zidovudine results in decreased expression of ABCC3 mRNA

PMID:24292225 PMID:27765674

NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253

G

ATP binding cassette subfamily C member 4 (PEL blood group)

affects abundance
increases export
increases expression

ABCC4 protein affects the abundance of Zidovudine
ABCC4 protein results in increased export of Zidovudine
Zidovudine results in increased expression of ABCC4 mRNA

PMID:15456083 PMID:18364470 PMID:18535159

NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475

G

ATP binding cassette subfamily C member 5

increases export
increases expression

ABCC5 protein results in increased export of Zidovudine
Zidovudine results in increased expression of ABCC5 mRNA

PMID:15456083 PMID:18535159 PMID:24292225

NCBI chr 3:183,919,934...184,017,884
Ensembl chr 3:183,919,934...184,017,939

G

ATP binding cassette subfamily C member 6

increases expression

Zidovudine results in increased expression of ABCC6 mRNA

NCBI chr16:16,149,565...16,223,494
Ensembl chr16:16,149,565...16,223,522

G

ATP binding cassette subfamily D member 1

increases expression

Zidovudine results in increased expression of ABCD1 mRNA

NCBI chr X:153,724,856...153,744,755
Ensembl chr X:153,724,856...153,744,755

G

ATP binding cassette subfamily F member 2

increases expression

Zidovudine results in increased expression of ABCF2 mRNA

NCBI chr 7:151,211,484...151,227,205
Ensembl chr 7:151,211,484...151,227,205

G

ATP binding cassette subfamily F member 3

increases expression

Zidovudine results in increased expression of ABCF3 mRNA

NCBI chr 3:184,186,199...184,194,005
Ensembl chr 3:184,186,095...184,194,012

G

ATP binding cassette subfamily G member 2 (JR blood group)

multiple interactions
increases expression
decreases expression
decreases export
increases export

3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in decreased export of Zidovudine]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]; Elacridar inhibits the reaction [ABCG2 protein results in decreased export of Zidovudine]; Elacridar inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]; Nelfinavir inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]; pluronic block copolymer p85 inhibits the reaction [ABCG2 protein results in increased export of Zidovudine]
Zidovudine results in increased expression of ABCG2 protein
Zidovudine results in decreased expression of ABCG2 mRNA
Zidovudine results in increased expression of ABCG2 mRNA

PMID:17437964 PMID:19056916 PMID:24292225 PMID:27765674 PMID:28705594 More...

NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628

G

ATP binding cassette subfamily G member 8

decreases expression

Zidovudine results in decreased expression of ABCG8 mRNA

NCBI chr 2:43,838,971...43,882,988
Ensembl chr 2:43,831,942...43,882,988

G

acetyl-CoA carboxylase alpha

affects expression

Zidovudine affects the expression of ACACA mRNA

NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836

G

acetyl-CoA carboxylase beta

affects expression

Zidovudine affects the expression of ACACB mRNA

NCBI chr12:109,111,189...109,268,226
Ensembl chr12:109,116,587...109,268,226

G

acyl-CoA dehydrogenase short/branched chain

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ACADSB mRNA

NCBI chr10:123,009,006...123,058,290
Ensembl chr10:123,008,979...123,058,290

G

acyl-CoA synthetase long chain family member 6

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of ACSL6 mRNA

NCBI chr 5:131,949,973...132,012,213
Ensembl chr 5:131,949,973...132,012,243

G

adenosine deaminase

increases expression

Zidovudine results in increased expression of ADA protein

NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252

G

adiponectin, C1Q and collagen domain containing

decreases expression
multiple interactions

Zidovudine results in decreased expression of ADIPOQ protein
Zidovudine results in decreased expression of ADIPOQ mRNA; Zidovudine results in decreased expression of ADIPOQ protein
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ADIPOQ mRNA

PMID:15865214 PMID:16931933 PMID:17503663 PMID:17668557

NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463

G

AE binding protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of AEBP1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of AEBP1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of AEBP1 mRNA

NCBI chr 7:44,104,345...44,114,560
Ensembl chr 7:44,104,345...44,114,562

G

actin filament associated protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of AFAP1 mRNA

NCBI chr 4:7,758,713...7,939,861
Ensembl chr 4:7,758,714...7,939,926

G

1-acylglycerol-3-phosphate O-acyltransferase 3

multiple interactions
increases expression

[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA]
Zidovudine results in increased expression of AGPAT3 mRNA

NCBI chr21:43,865,223...43,987,592
Ensembl chr21:43,865,223...43,987,592

G

AKT serine/threonine kinase 1

increases phosphorylation

Zidovudine results in increased phosphorylation of AKT1 protein

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

albumin

affects binding

Zidovudine binds to ALB protein

PMID:15814459 PMID:16336266

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

arachidonate 5-lipoxygenase activating protein

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ALOX5AP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ALOX5AP mRNA

NCBI chr13:30,713,485...30,764,426
Ensembl chr13:30,713,478...30,764,426

G

apolipoprotein A5

multiple interactions
decreases expression

[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA]
Zidovudine results in decreased expression of APOA5 mRNA

NCBI chr11:116,789,367...116,792,420
Ensembl chr11:116,789,367...116,792,420

G

adenine phosphoribosyltransferase

increases mutagenesis

Zidovudine results in increased mutagenesis of APRT gene

NCBI chr16:88,809,339...88,811,928
Ensembl chr16:88,809,339...88,811,937

G

aquaporin 9

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of AQP9 mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of AQP9 mRNA

PMID:18313992 PMID:20370541

NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911

G

cAMP regulated phosphoprotein 21

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ARPP21 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ARPP21 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ARPP21 mRNA

NCBI chr 3:35,638,853...35,794,486
Ensembl chr 3:35,638,945...35,794,496

G

acid sensing ion channel subunit 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ASIC2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ASIC2 mRNA

NCBI chr17:33,013,087...34,156,768
Ensembl chr17:33,013,087...34,174,964

G

argininosuccinate lyase

multiple interactions
increases activity

[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein; silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein]
Zidovudine results in increased activity of ASL protein

NCBI chr 7:66,075,819...66,093,576
Ensembl chr 7:66,075,800...66,094,697

G

asparagine synthetase (glutamine-hydrolyzing)

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ASNS mRNA

NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542

G

argininosuccinate synthase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ASS1 mRNA

NCBI chr 9:130,444,707...130,501,274
Ensembl chr 9:130,444,961...130,501,274

G

activating transcription factor 3

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ATF3 mRNA

NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ATP2A2 mRNA

NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093

G

ATP synthase F1 subunit gamma

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5F1C mRNA

NCBI chr10:7,788,177...7,807,801
Ensembl chr10:7,788,147...7,807,815

G

ATP synthase F1 subunit delta

decreases expression

Zidovudine results in decreased expression of ATP5F1D mRNA

NCBI chr19:1,241,751...1,244,825
Ensembl chr19:1,241,746...1,244,825

G

ATP synthase membrane subunit c locus 3

increases expression
multiple interactions

Zidovudine results in increased expression of ATP5MC3 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5MC3 mRNA

PMID:16894629 PMID:18313992

NCBI chr 2:175,176,258...175,181,710
Ensembl chr 2:175,176,258...175,181,710

G

ATP synthase membrane subunit e

increases expression

Zidovudine results in increased expression of ATP5ME mRNA

NCBI chr 4:672,436...674,276
Ensembl chr 4:672,436...674,330

G

ATP synthase membrane subunit f

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5MF mRNA

NCBI chr 7:99,458,195...99,466,167
Ensembl chr 7:99,448,475...99,466,186

G

ATP synthase membrane subunit g

increases expression

Zidovudine results in increased expression of ATP5MG mRNA

NCBI chr11:118,401,606...118,409,847
Ensembl chr11:118,401,346...118,433,278

G

ATP synthase peripheral stalk-membrane subunit b

increases expression

Zidovudine results in increased expression of ATP5PB mRNA

NCBI chr 1:111,449,464...111,462,773
Ensembl chr 1:111,448,864...111,462,773

G

ATP synthase peripheral stalk subunit d

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5PD mRNA

NCBI chr17:75,038,863...75,046,969
Ensembl chr17:75,038,863...75,046,985

G

ATP synthase peripheral stalk subunit F6

increases expression
multiple interactions

Zidovudine results in increased expression of ATP5PF mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of ATP5PF mRNA

PMID:16894629 PMID:18313992

NCBI chr21:25,724,500...25,735,653
Ensembl chr21:25,716,503...25,735,673

G

ATP synthase peripheral stalk subunit OSCP

increases expression
multiple interactions

Zidovudine results in increased expression of ATP5PO mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of ATP5PO mRNA

PMID:16894629 PMID:18313992

NCBI chr21:33,903,453...33,915,804
Ensembl chr21:33,903,453...33,915,814

G

ATPase phospholipid transporting 8B1

decreases expression

Zidovudine results in decreased expression of ATP8B1 mRNA

NCBI chr18:57,646,426...57,803,315
Ensembl chr18:57,646,426...57,803,315

G

BCL2 apoptosis regulator

affects response to substance
increases expression
multiple interactions
decreases expression

BCL2 protein affects the susceptibility to Zidovudine
Zidovudine results in increased expression of BCL2 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of BCL2 mRNA
Drugs, Chinese Herbal promotes the reaction [Zidovudine results in decreased expression of BCL2 mRNA]

PMID:9850737 PMID:17696246 PMID:18313992 PMID:29594326

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 interacting protein 3 like

increases expression

Zidovudine results in increased expression of BNIP3L protein

NCBI chr 8:26,383,054...26,413,127
Ensembl chr 8:26,383,054...26,505,636

G

bone marrow stromal cell antigen 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of BST2 mRNA

NCBI chr19:17,402,939...17,405,630
Ensembl chr19:17,402,939...17,405,630

G

BTG anti-proliferation factor 2

increases expression

Zidovudine results in increased expression of BTG2 mRNA

NCBI chr 1:203,305,519...203,309,602
Ensembl chr 1:203,305,491...203,309,602

G

complement C1r

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C1R mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C1R mRNA

NCBI chr12:7,080,219...7,092,445
Ensembl chr12:7,080,214...7,092,540

G

complement C3a receptor 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of C3AR1 mRNA
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of C3AR1 mRNA

PMID:16931933 PMID:20370541

NCBI chr12:8,056,844...8,066,359
Ensembl chr12:8,056,844...8,066,359

G

cysteinyl-tRNA synthetase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of CARS1 mRNA

NCBI chr11:3,000,929...3,057,423
Ensembl chr11:3,000,922...3,057,613

G

caspase 3

multiple interactions
increases cleavage
increases expression
increases activity

[Acrolein co-treated with Zidovudine] results in increased cleavage of CASP3 protein; Drugs, Chinese Herbal promotes the reaction [Zidovudine results in increased expression of CASP3 mRNA]
Zidovudine results in increased cleavage of CASP3 protein
Zidovudine results in increased expression of CASP3 protein
Zidovudine results in increased activity of CASP3 protein
2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine inhibits the reaction [Zidovudine results in increased expression of CASP3 protein]; glutapyrone inhibits the reaction [Zidovudine results in increased expression of CASP3 protein]; tauropyrone inhibits the reaction [Zidovudine results in increased expression of CASP3 protein]

PMID:16601281 PMID:17696246 PMID:17943461 PMID:18801031 PMID:27238871

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 5

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of CASP5 mRNA

NCBI chr11:104,994,243...105,023,168
Ensembl chr11:104,994,235...105,023,168

G

caspase 8

increases cleavage
multiple interactions

Zidovudine results in increased cleavage of CASP8 protein
Acrolein promotes the reaction [Zidovudine results in increased cleavage of CASP8 protein]; Zidovudine promotes the reaction [Acrolein results in increased cleavage of CASP8 protein]

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

catalase

decreases response to substance

CAT protein results in decreased susceptibility to Zidovudine

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

C-C motif chemokine ligand 2

increases expression

Zidovudine results in increased expression of CCL2 protein

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

cyclin A2

multiple interactions
decreases expression

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNA2 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of CCNA2 mRNA
Zidovudine results in decreased expression of CCNA2 mRNA

PMID:15784690 PMID:20370541

NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883

G

cyclin B1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNB1 mRNA

NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245

G

cyclin C

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CCNC mRNA

NCBI chr 6:99,542,387...99,568,814
Ensembl chr 6:99,542,387...99,568,825

G

cyclin D1

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of CCND1 mRNA
Zidovudine results in increased expression of CCND1 mRNA

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

cyclin D2

multiple interactions
decreases expression

[Zidovudine co-treated with Lamivudine] results in decreased expression of CCND2 mRNA
Zidovudine results in decreased expression of CCND2 mRNA

NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353

G

cyclin E2

decreases expression
multiple interactions

Zidovudine results in decreased expression of CCNE2 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of CCNE2 mRNA

NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678

G

cyclin L2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNL2 mRNA

NCBI chr 1:1,385,711...1,399,335
Ensembl chr 1:1,385,711...1,399,335

G

C-C motif chemokine receptor 5

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CCR5 mRNA

NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,946...46,376,206

G

CD1c molecule

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of CD1C mRNA

NCBI chr 1:158,289,923...158,294,774
Ensembl chr 1:158,289,923...158,294,774

G

CD36 molecule (CD36 blood group)

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CD36 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CD36 mRNA

NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277

G

CD44 molecule (IN blood group)

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of CD44 mRNA

NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402

G

CD83 molecule

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CD83 mRNA

NCBI chr 6:14,117,256...14,136,918
Ensembl chr 6:14,117,256...14,136,918

G

cell division cycle 25A

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CDC25A mRNA

NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417

G

cell division cycle associated 8

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDCA8 mRNA

NCBI chr 1:37,692,516...37,709,719
Ensembl chr 1:37,692,481...37,709,719

G

cyclin dependent kinase 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK1 mRNA

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cyclin dependent kinase 4

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK4 mRNA

NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013

G

cyclin dependent kinase 6

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDK6 mRNA

NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573

G

cyclin dependent kinase 7

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of CDK7 mRNA

NCBI chr 5:69,234,795...69,277,430
Ensembl chr 5:69,234,795...69,277,430

G

cyclin dependent kinase inhibitor 1A

multiple interactions
affects expression
decreases expression

[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1A mRNA
Zidovudine affects the expression of CDKN1A protein
Zidovudine results in decreased expression of CDKN1A mRNA

PMID:15784690 PMID:18389896

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337

G

cyclin dependent kinase inhibitor 1B

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1B mRNA

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

G

cyclin dependent kinase inhibitor 1C

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1C mRNA

NCBI chr11:2,883,218...2,885,775
Ensembl chr11:2,883,213...2,885,775

G

cyclin dependent kinase inhibitor 2A

increases expression
affects expression

Zidovudine results in increased expression of CDKN2A mRNA; Zidovudine results in increased expression of CDKN2A protein
Zidovudine affects the expression of CDKN2A protein

PMID:16797627 PMID:18389896

NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301

G

cyclin dependent kinase inhibitor 2C

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN2C mRNA

NCBI chr 1:50,968,706...50,974,634
Ensembl chr 1:50,960,745...50,974,634

G

CCAAT enhancer binding protein alpha

decreases expression

Zidovudine results in decreased expression of CEBPA protein

NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534

G

complement factor D

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CFD mRNA

NCBI chr19:859,664...863,641
Ensembl chr19:859,453...867,884

G

checkpoint kinase 1

increases phosphorylation
decreases expression

Zidovudine results in increased phosphorylation of CHEK1 protein
Zidovudine results in decreased expression of CHEK1 protein

NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255

G

checkpoint kinase 2

decreases expression
increases phosphorylation

Zidovudine results in decreased expression of CHEK2 protein
Zidovudine results in increased phosphorylation of CHEK2 protein

NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422

G

chimerin 1

decreases expression

Zidovudine results in decreased expression of CHN1 mRNA

NCBI chr 2:174,798,809...175,005,381
Ensembl chr 2:174,798,809...175,005,381

G

cell death inducing DFFA like effector c

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CIDEC mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CIDEC mRNA

NCBI chr 3:9,866,710...9,880,253
Ensembl chr 3:9,866,711...9,880,255

G

chloride voltage-gated channel 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of CLCN3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CLCN3 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of CLCN3 mRNA

NCBI chr 4:169,620,578...169,723,673
Ensembl chr 4:169,612,633...169,723,673

G

C-type lectin domain family 2 member A

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of CLEC2I mRNA

NCBI chr12:9,877,742...9,932,370
Ensembl chr12:9,898,673...9,932,370

G

catechol-O-methyltransferase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNA

NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,371...19,969,975

G

cytochrome c oxidase copper chaperone COX11

decreases expression

Zidovudine results in decreased expression of COX11 mRNA

NCBI chr17:54,951,902...54,968,785
Ensembl chr17:54,951,902...54,968,703

G

cytochrome c oxidase assembly homolog COX15

decreases expression

Zidovudine results in decreased expression of COX15 mRNA

NCBI chr10:99,694,293...99,732,127
Ensembl chr10:99,710,868...99,732,127

G

cytochrome c oxidase subunit 5A

decreases expression
multiple interactions

Zidovudine results in decreased expression of COX5A protein
[Zidovudine co-treated with Lamivudine] results in decreased expression of COX5A mRNA

PMID:7807166 PMID:18313992

NCBI chr15:74,919,791...74,938,073
Ensembl chr15:74,919,791...74,938,083

G

cytochrome c oxidase subunit 5B

multiple interactions
decreases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of COX5B mRNA
Zidovudine results in decreased expression of COX5B protein

PMID:7807166 PMID:18313992

NCBI chr 2:97,646,062...97,648,383
Ensembl chr 2:97,646,062...97,648,383

G

cytochrome c oxidase subunit 6A1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of COX6A1 mRNA

NCBI chr12:120,438,113...120,440,730
Ensembl chr12:120,438,090...120,440,737

G

cytochrome c oxidase subunit 6C

decreases expression
multiple interactions

Zidovudine results in decreased expression of COX6C protein
[Zidovudine co-treated with Lamivudine] results in increased expression of COX6C mRNA

PMID:7807166 PMID:18313992

NCBI chr 8:99,877,865...99,893,707
Ensembl chr 8:99,873,200...99,893,707

G

cytochrome c oxidase subunit 7A1

decreases expression

Zidovudine results in decreased expression of COX7A1 protein

NCBI chr19:36,150,922...36,152,447
Ensembl chr19:36,150,922...36,152,449

G

cytochrome c oxidase subunit 7A2

increases expression

Zidovudine results in increased expression of COX7A2 mRNA

NCBI chr 6:75,237,675...75,250,298
Ensembl chr 6:75,237,675...75,250,323

G

cytochrome c oxidase subunit 7B

increases expression
decreases expression

Zidovudine results in increased expression of COX7B mRNA
Zidovudine results in decreased expression of COX7B protein

PMID:7807166 PMID:16894629

NCBI chr X:77,899,468...77,907,376
Ensembl chr X:77,899,440...77,907,376

G

cytochrome c oxidase subunit 7C

decreases expression
multiple interactions

Zidovudine results in decreased expression of COX7C protein
[Zidovudine co-treated with Lamivudine] results in increased expression of COX7C mRNA

PMID:7807166 PMID:18313992

NCBI chr 5:86,617,941...86,620,962
Ensembl chr 5:86,617,928...86,620,962

G

copine 5

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CPNE5 mRNA

NCBI chr 6:36,740,775...36,839,998
Ensembl chr 6:36,740,775...36,839,444

G

carnitine palmitoyltransferase 1A

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of CPT1A mRNA
Zidovudine results in increased expression of CPT1A mRNA

PMID:14576092 PMID:18313992

NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410

G

carnitine O-acetyltransferase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of CRAT mRNA

NCBI chr 9:129,094,794...129,110,793
Ensembl chr 9:129,094,142...129,111,189

G

citrate synthase

affects expression
decreases expression

Zidovudine affects the expression of CS mRNA
Zidovudine results in decreased expression of CS protein

PMID:1892364 PMID:20032539

NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391

G

colony stimulating factor 2

multiple interactions

[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of CSF2RA mRNA]; [IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of IL3RA mRNA]

NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170

G

colony stimulating factor 2 receptor subunit alpha

multiple interactions
decreases expression

[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of CSF2RA mRNA]

NCBI chr  X:1,268,814...1,325,218
NCBI chr  Y:1,268,814...1,325,218
Ensembl chr  Y:1,268,800...1,310,381
Ensembl chr  X:1,268,800...1,310,381

G

chondroitin sulfate N-acetylgalactosaminyltransferase 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of CSGALNACT1 mRNA

NCBI chr 8:19,404,161...19,757,908
Ensembl chr 8:19,404,161...19,758,029

G

cullin 7

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CUL7 mRNA

NCBI chr 6:43,037,617...43,053,851
Ensembl chr 6:43,037,617...43,053,943

G

cytochrome b5 type A

multiple interactions
decreases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of CYB5A mRNA
Zidovudine results in decreased expression of CYB5A mRNA
[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA]

PMID:18313992 PMID:28619387

NCBI chr18:74,250,846...74,291,963
Ensembl chr18:74,250,846...74,291,973

G

cytochrome P450 family 11 subfamily A member 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of CYP11A1 mRNA

NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646

G

cytochrome P450 family 1 subfamily B member 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of CYP1B1 mRNA

NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902

G

cytochrome P450 family 3 subfamily A member 4

multiple interactions

[SOD2 co-treated with CYP3A4] affects the susceptibility to Zidovudine

NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248

G

decorin

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DCN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DCN mRNA

NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217

G

DNA damage inducible transcript 3

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of DDIT3 mRNA
Zidovudine results in increased expression of DDIT3 mRNA

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

discoidin domain receptor tyrosine kinase 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of DDR2 mRNA

NCBI chr 1:162,630,863...162,787,405
Ensembl chr 1:162,631,373...162,787,405

G

DExD/H-box 60 like

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of DDX60L mRNA

NCBI chr 4:168,356,735...168,480,492
Ensembl chr 4:168,356,735...168,537,786

G

dihydrofolate reductase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNA

NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983

G

diablo IAP-binding mitochondrial protein

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of DIABLO mRNA

NCBI chr12:122,207,662...122,227,456
Ensembl chr12:122,207,668...122,226,062

G

dihydrolipoamide S-succinyltransferase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of DLST mRNA

NCBI chr14:74,881,916...74,903,743
Ensembl chr14:74,881,891...74,903,743

G

dystrophin

affects localization

Zidovudine affects the localization of DMD protein

NCBI chr X:31,119,222...33,339,388
Ensembl chr X:31,097,677...33,339,609

G

DNA replication helicase/nuclease 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of DNA2 mRNA

NCBI chr10:68,414,064...68,472,521
Ensembl chr10:68,414,064...68,472,121

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of DNAJA3 mRNA

NCBI chr16:4,425,868...4,456,775
Ensembl chr16:4,425,805...4,456,775

G

dynamin 1 like

multiple interactions
affects localization

[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of and affects the phosphorylation of DNM1L protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of DNM1L mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the localization of DNM1L protein
Zidovudine affects the localization of DNM1L protein

NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650

G

deltex E3 ubiquitin ligase 3L

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of DTX3L mRNA

NCBI chr 3:122,564,338...122,575,203
Ensembl chr 3:122,564,338...122,575,203

G

deoxythymidylate kinase

multiple interactions
affects response to substance

[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of and affects the phosphorylation of DNM1L protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of DNM1L mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 protein; [DTYMK protein affects the susceptibility to Zidovudine] which affects the localization of DNM1L protein; DTYMK gene mutant form results in increased phosphorylation of and results in increased susceptibility to Zidovudine

PMID:17375075 PMID:28683400

NCBI chr 2:241,675,747...241,686,815
Ensembl chr 2:241,675,747...241,686,944

G

dual specificity phosphatase 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of DUSP3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DUSP3 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of DUSP3 mRNA

NCBI chr17:43,766,125...43,778,977
Ensembl chr17:43,766,125...43,778,977

G

enoyl-CoA hydratase, short chain 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of ECHS1 mRNA

NCBI chr10:133,362,485...133,373,354
Ensembl chr10:133,362,485...133,373,354

G

enoyl-CoA delta isomerase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of ECI1 mRNA

NCBI chr16:2,239,402...2,251,587
Ensembl chr16:2,239,402...2,252,300

G

endothelin 1

multiple interactions
increases secretion

coenzyme Q10 inhibits the reaction [Zidovudine results in increased secretion of EDN1 protein]

NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194

G

early growth response 1

multiple interactions

[Zidovudine co-treated with Arsenic Trioxide] results in increased expression of EGR1 mRNA

NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303

G

ETS homologous factor

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of EHF mRNA

NCBI chr11:34,621,093...34,663,288
Ensembl chr11:34,621,093...34,663,288

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

Zidovudine results in increased phosphorylation of EIF2S1 protein

NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of EIF4EBP1 mRNA

NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365

G

ELOVL fatty acid elongase 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ELOVL3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ELOVL3 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of ELOVL3 mRNA

NCBI chr10:102,224,767...102,229,589
Ensembl chr10:102,226,299...102,229,589

G

erythropoietin

increases expression
multiple interactions

Zidovudine results in increased expression of EPO protein
EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]; EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]]; Zidovudine inhibits the reaction [EPO protein binds to EPOR protein]; Zidovudine promotes the reaction [Staphylococcal Protein A results in increased expression of EPO protein]

PMID:1549625 PMID:1889487 PMID:3422548 PMID:7646543 PMID:9735323

NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700

G

erythropoietin receptor

multiple interactions
decreases expression

EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]; Zidovudine inhibits the reaction [EPO protein binds to EPOR protein]
Zidovudine results in decreased expression of EPOR mRNA; Zidovudine results in decreased expression of EPOR protein

PMID:1417927 PMID:7646543

NCBI chr19:11,377,207...11,384,314
Ensembl chr19:11,377,207...11,384,342

G

epithelial stromal interaction 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of EPSTI1 mRNA

NCBI chr13:42,886,388...42,992,241
Ensembl chr13:42,886,388...42,992,271

G

estrogen receptor 1

affects localization

Zidovudine affects the localization of ESR1 protein

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

estrogen receptor 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of ESR2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ESR2 mRNA

NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112

G

ETS variant transcription factor 6

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ETV6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ETV6 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of ETV6 mRNA

NCBI chr12:11,649,674...11,895,377
Ensembl chr12:11,649,674...11,895,377

G

fatty acid binding protein 4

affects expression

Zidovudine affects the expression of FABP4 mRNA

NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236

G

fatty acid desaturase 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FADS2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of FADS2 mRNA

NCBI chr11:61,816,203...61,867,354
Ensembl chr11:61,792,980...61,867,354

G

Fas apoptotic inhibitory molecule

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of FAIM mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of FAIM mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of FAIM mRNA

NCBI chr 3:138,608,771...138,633,376
Ensembl chr 3:138,608,606...138,633,376

G

Fas cell surface death receptor

increases expression

Zidovudine results in increased expression of FAS protein

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

Fas ligand

increases expression
multiple interactions

Zidovudine results in increased expression of FASLG protein
Zidovudine results in increased expression of FASLG mRNA
Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine results in increased expression of FASLG mRNA]; Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]
[Acrolein co-treated with Zidovudine] results in increased expression of FASLG protein; Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Hydralazine inhibits the reaction [Zidovudine results in increased expression of FASLG mRNA]; Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]; Zidovudine promotes the reaction [Acrolein results in increased expression of FASLG mRNA]; Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]

PMID:17943461 PMID:27238871

NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876

G

fatty acid synthase

affects expression
decreases expression
multiple interactions

Zidovudine affects the expression of FASN mRNA
Zidovudine results in decreased expression of FASN protein
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FASN mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of FASN mRNA

PMID:11741158 PMID:15722030 PMID:20032539

NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294

G

Fc gamma receptor Ia

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of FCGR1A mRNA

NCBI chr 1:149,782,694...149,800,609
Ensembl chr 1:149,782,671...149,791,675

G

ferredoxin reductase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of FDXR mRNA

NCBI chr17:74,862,497...74,872,994
Ensembl chr17:74,862,497...74,873,031

G

fibrinogen like 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of FGL2 mRNA

NCBI chr 7:77,193,369...77,199,819
Ensembl chr 7:77,193,369...77,199,848

G

fumarate hydratase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of FH1 mRNA

NCBI chr 1:241,497,603...241,519,755
Ensembl chr 1:241,497,511...241,519,799

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]]

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

forkhead box P3

multiple interactions

[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of FOXP3 mRNA

NCBI chr X:49,250,438...49,264,710
Ensembl chr X:49,250,438...49,264,800

G

G0/G1 switch 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of G0S2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of G0S2 mRNA

NCBI chr 1:209,675,412...209,676,390
Ensembl chr 1:209,675,412...209,676,390

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of G6PC1 mRNA

NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438

G

glucosidase alpha, neutral C

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of GANC mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of GANC mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of GANC mRNA

NCBI chr15:42,273,201...42,353,666
Ensembl chr15:42,273,201...42,353,666

G

glycyl-tRNA synthetase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of GARS1 mRNA

NCBI chr 7:30,594,735...30,634,033
Ensembl chr 7:30,580,533...30,634,033

G

growth arrest specific 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of GAS1 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of GAS1 mRNA

PMID:15784690 PMID:20370541

NCBI chr 9:86,944,362...86,947,506
Ensembl chr 9:86,944,362...86,947,506

G

GATA binding protein 1

decreases activity
decreases expression

Zidovudine results in decreased activity of GATA1 protein
Zidovudine results in decreased expression of GATA1 mRNA

PMID:8599995 PMID:10651068

NCBI chr X:48,786,590...48,794,311
Ensembl chr X:48,786,540...48,794,311

G

guanylate binding protein 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP1 mRNA

NCBI chr 1:89,052,319...89,065,208
Ensembl chr 1:89,051,882...89,065,360

G

guanylate binding protein 4

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP4 mRNA

NCBI chr 1:89,181,144...89,198,942
Ensembl chr 1:89,181,144...89,198,942

G

glutamic--pyruvic transaminase

multiple interactions
increases activity

Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]; silybin inhibits the reaction [Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]]

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

growth factor receptor bound protein 7

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of GRB7 mRNA

NCBI chr17:39,737,938...39,747,285
Ensembl chr17:39,737,927...39,747,291

G

grainyhead like transcription factor 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of GRHL2 mRNA

NCBI chr 8:101,492,439...101,681,200
Ensembl chr 8:101,492,439...101,669,726

G

general transcription factor IIH subunit 1

increases expression

Zidovudine results in increased expression of GTF2H1 mRNA; Zidovudine results in increased expression of GTF2H1 protein

NCBI chr11:18,322,567...18,367,045
Ensembl chr11:18,322,295...18,367,045

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of GUCY1B1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of GUCY1B1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of GUCY1B1 mRNA

NCBI chr 4:155,759,021...155,807,811
Ensembl chr 4:155,758,992...155,807,811

G

glycophorin A (MNS blood group)

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased mutagenesis of GYPA gene

NCBI chr 4:144,109,303...144,140,718
Ensembl chr 4:144,109,303...144,140,751

G

H2A.X variant histone

increases phosphorylation

Zidovudine results in increased phosphorylation of H2AX protein

NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465

G

H4 clustered histone 3

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of H4C3 mRNA

NCBI chr 6:26,103,933...26,104,337
Ensembl chr 6:26,103,933...26,104,337

G

H4 clustered histone 9

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of H4C9 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of H4C9 mRNA

NCBI chr 6:27,139,282...27,139,678
Ensembl chr 6:27,139,282...27,139,678

G

hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase

affects expression

Zidovudine affects the expression of H6PD mRNA

NCBI chr 1:9,234,774...9,271,337
Ensembl chr 1:9,234,774...9,271,337

G

hydroxyacyl-CoA dehydrogenase

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of HADH mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of HADH mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of HADH mRNA

NCBI chr 4:107,989,889...108,035,171
Ensembl chr 4:107,989,714...108,035,241

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of HADHA mRNA

NCBI chr 2:26,190,635...26,244,632
Ensembl chr 2:26,190,635...26,244,672

G

HCLS1 associated protein X-1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of HAX1 mRNA

NCBI chr 1:154,272,629...154,275,875
Ensembl chr 1:154,272,355...154,275,875

G

hemoglobin subunit beta

decreases expression

Zidovudine results in decreased expression of HBB mRNA

NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395

G

hyperpolarization activated cyclic nucleotide gated potassium channel 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of HCN1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of HCN1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of HCN1 mRNA

NCBI chr 5:45,254,948...45,696,380
Ensembl chr 5:45,254,948...45,696,498

G

high density lipoprotein binding protein

decreases expression

Zidovudine results in decreased expression of HDLBP mRNA

NCBI chr 2:241,227,291...241,315,672
Ensembl chr 2:241,227,264...241,317,061

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of HERC6 mRNA

NCBI chr 4:88,378,852...88,443,097
Ensembl chr 4:88,378,739...88,443,097

G

major histocompatibility complex, class I, A

affects expression

Zidovudine affects the expression of HLA-A mRNA

NCBI chr 6:29,942,532...29,945,870
Ensembl chr 6:29,941,260...29,949,572

G

major histocompatibility complex, class I, B

affects expression

Zidovudine affects the expression of HLA-B mRNA

NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,353,872...31,367,067

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of HMGCS2 mRNA

NCBI chr 1:119,747,996...119,768,932
Ensembl chr 1:119,748,002...119,768,905

G

heme oxygenase 1

increases expression

Zidovudine results in increased expression of HMOX1 mRNA

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

hypoxanthine phosphoribosyltransferase 1

increases mutagenesis

Zidovudine results in increased mutagenesis of HPRT1 exon

NCBI chr X:134,460,165...134,500,668
Ensembl chr X:134,460,165...134,520,513

G

HRas proto-oncogene, GTPase

multiple interactions

[Zidovudine co-treated with Tetradecanoylphorbol Acetate] results in increased mutagenesis of HRAS gene

NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321

G

harakiri, BCL2 interacting protein

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of HRK mRNA

NCBI chr12:116,856,144...116,881,441
Ensembl chr12:116,856,144...116,881,441

G

hydroxysteroid 11-beta dehydrogenase 1

affects expression

Zidovudine affects the expression of HSD11B1 mRNA

NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B2 mRNA

NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054

G

heat shock protein family D (Hsp60) member 1

affects expression

Zidovudine affects the expression of HSPD1 protein

NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of IDH2 mRNA

NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477

G

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of IDH3A mRNA

NCBI chr15:78,149,362...78,171,945
Ensembl chr15:78,131,498...78,171,945

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of IDH3G mRNA

NCBI chr X:153,785,768...153,794,375
Ensembl chr X:153,785,766...153,794,512

G

interferon alpha inducible protein 27

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI27 mRNA

NCBI chr14:94,105,894...94,116,690
Ensembl chr14:94,104,836...94,116,695

G

interferon induced protein 35

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI35 mRNA

NCBI chr17:43,006,784...43,014,456
Ensembl chr17:43,006,740...43,014,456

G

interferon induced protein 44 like

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI44L mRNA

NCBI chr 1:78,620,448...78,646,145
Ensembl chr 1:78,619,902...78,646,145

G

interferon alpha inducible protein 6

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI6 mRNA

NCBI chr 1:27,666,064...27,672,192
Ensembl chr 1:27,666,064...27,672,212

G

interferon induced with helicase C domain 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIH1 mRNA

NCBI chr 2:162,267,074...162,318,684
Ensembl chr 2:162,267,074...162,318,684

G

interferon induced protein with tetratricopeptide repeats 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT1 mRNA

NCBI chr10:89,392,623...89,406,487
Ensembl chr10:89,392,546...89,406,487

G

interferon induced protein with tetratricopeptide repeats 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT2 mRNA

NCBI chr10:89,302,046...89,309,271
Ensembl chr10:89,283,694...89,309,271

G

interferon induced protein with tetratricopeptide repeats 5

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT5 mRNA

NCBI chr10:89,414,568...89,420,997
Ensembl chr10:89,414,568...89,421,605

G

interferon induced transmembrane protein 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IFITM1 mRNA

NCBI chr11:314,040...315,272
Ensembl chr11:310,041...315,272

G

interferon alpha 1

multiple interactions
affects expression

[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of FOXP3 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 protein; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL4 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in increased expression of IL2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CD1C mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDCA8 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDK6 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of CYP1B1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of DDR2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of GAS1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of GRB7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of H4C3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of LGALS1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of MVD mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of PGR mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of PIERCE1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of PKMYT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of RAB17 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of RAB3B mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of RASSF7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of SAPCD2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TMEM97 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TNC mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRDMT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRIQK mRNA; [Zidovudine co-treated with IFNA1 protein] results in decreased expression of WDR62 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of AQP9 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of BST2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of C3AR1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNA2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNB1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNL2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCR5 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CDC25A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CPNE5 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of CSGALNACT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of DDX60L mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of DNA2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of DTX3L mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of EHF mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of EPSTI1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of ERV3-2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of FCGR1A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of FGL2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of GBP4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of HERC6 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI27 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI35 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI44L mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFI6 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIH1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFIT5 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IFITM1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of ISG15 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of ITIH4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of JAK2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LAMP3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LAP3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LGALS9 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRA1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRB3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRB4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of LY6E mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MNDA mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MOV10 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MT1G mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MT2A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MX1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of MX2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of NEXN mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of NT5C3A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of NUB1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of NUF2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS3 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PARP9 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PCNA mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PF4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PIK3AP1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of PLSCR1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of RGS6 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of RNF213 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of RPT4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of RSAD2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SAMD9L mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SCIMP mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SERPING1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SHFL mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SIGLEC1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC22A23 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC24A4 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC7A7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TCN1 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TCN2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TLR7 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TNFSF10 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TNFSF13B mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TNNI2 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TRIM22 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TRMT44 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TTC21A mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of TXLNGY mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of USP18 mRNA; [Zidovudine co-treated with IFNA1 protein] results in increased expression of ZNF629 mRNA; IRF4 protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]; REL protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]
Zidovudine affects the expression of IFNA1 protein

PMID:9612607 PMID:17138822 PMID:20370541 PMID:23962110

NCBI chr 9:21,440,439...21,441,316
Ensembl chr 9:21,440,439...21,441,316

G

interferon gamma

affects expression
multiple interactions

Zidovudine affects the expression of IFNG protein
[Arsenic co-treated with Zidovudine co-treated with IFNG protein] results in increased expression of IL2 mRNA

PMID:9612607 PMID:23962110

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

IKAROS family zinc finger 4

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of IKZF4 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of IKZF4 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of IKZF4 mRNA

NCBI chr12:56,007,504...56,038,435
Ensembl chr12:56,007,659...56,038,435

G

interleukin 10

multiple interactions

[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL10 protein

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 1 alpha

increases expression

Zidovudine results in increased expression of IL1A protein

NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493

G

interleukin 1 beta

increases expression

Zidovudine results in increased expression of IL1B mRNA; Zidovudine results in increased expression of IL1B protein

PMID:9184656 PMID:17668557

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 2

multiple interactions

[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in increased expression of IL2 mRNA; [Arsenic co-treated with Zidovudine co-treated with IFNG protein] results in increased expression of IL2 mRNA

NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725

G

interleukin 27 receptor subunit alpha

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of IL27RA mRNA

NCBI chr19:14,031,762...14,053,218
Ensembl chr19:14,031,762...14,053,218

G

interleukin 2 receptor subunit alpha

multiple interactions
decreases expression

Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA mRNA]; Zidovudine promotes the reaction [Zalcitabine results in decreased expression of IL2RA protein]
Zidovudine results in decreased expression of IL2RA mRNA; Zidovudine results in decreased expression of IL2RA protein

NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370

G

interleukin 3

multiple interactions

[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of CSF2RA mRNA]; [IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of IL3RA mRNA]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of EPOR mRNA]]; IL3 protein promotes the reaction [EPO protein inhibits the reaction [Zidovudine results in decreased expression of FOS mRNA]]

PMID:7646543 PMID:12084393

NCBI chr 5:132,060,655...132,063,204
Ensembl chr 5:132,060,655...132,063,204

G

interleukin 3 receptor subunit alpha

multiple interactions
decreases expression

[IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of IL3RA mRNA]

NCBI chr  X:1,336,785...1,382,689
NCBI chr  Y:1,336,785...1,382,689
Ensembl chr  Y:1,336,616...1,382,689
Ensembl chr  X:1,336,616...1,382,689

G

interleukin 4

multiple interactions

[Arsenic co-treated with Zidovudine co-treated with IFNA1 protein] results in decreased expression of IL4 mRNA

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 6

increases expression

Zidovudine results in increased expression of IL6 protein

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

inositol polyphosphate-5-phosphatase E

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of INPP5E mRNA

NCBI chr 9:136,428,619...136,439,845
Ensembl chr 9:136,428,619...136,439,845

G

interferon regulatory factor 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF2 mRNA

NCBI chr 4:184,387,729...184,474,550
Ensembl chr 4:184,385,702...184,474,558

G

interferon regulatory factor 4

multiple interactions

IRF4 protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]

NCBI chr 6:391,752...411,443
Ensembl chr 6:391,739...411,443

G

interferon regulatory factor 7

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF7 mRNA

NCBI chr11:612,555...615,950
Ensembl chr11:612,553...615,983

G

ISG15 ubiquitin like modifier

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of ISG15 mRNA

NCBI chr 1:1,013,497...1,014,540
Ensembl chr 1:1,001,138...1,014,540

G

inter-alpha-trypsin inhibitor heavy chain 4

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of ITIH4 mRNA

NCBI chr 3:52,812,962...52,830,672
Ensembl chr 3:52,812,962...52,830,688

G

Janus kinase 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of JAK2 mRNA

NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948

G

potassium voltage-gated channel modifier subfamily G member 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of KCNG1 mRNA

NCBI chr20:51,003,656...51,023,107
Ensembl chr20:51,003,656...51,023,107

G

kinesin family member C2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of KIFC2 mRNA

NCBI chr 8:144,466,049...144,474,202
Ensembl chr 8:144,466,043...144,474,202

G

KLF transcription factor 4

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of KLF4 mRNA

NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482

G

kelch like family member 28

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of KLHL28 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of KLHL28 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of KLHL28 mRNA

NCBI chr14:44,924,324...44,961,947
Ensembl chr14:44,924,324...45,042,322

G

KRAS proto-oncogene, GTPase

increases mutagenesis

Zidovudine results in increased mutagenesis of KRAS gene

NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936

G

keratin 7

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of KRT7 mRNA

NCBI chr12:52,233,243...52,255,853
Ensembl chr12:52,232,520...52,252,186

G

kynureninase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of KYNU mRNA

NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833

G

laminin subunit beta 3

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of LAMB3 mRNA

NCBI chr 1:209,614,870...209,652,425
Ensembl chr 1:209,614,870...209,652,425

G

laminin subunit gamma 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of LAMC2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of LAMC2 mRNA

NCBI chr 1:183,186,264...183,258,968
Ensembl chr 1:183,186,238...183,245,127

G

lysosomal associated membrane protein 2

decreases expression

Zidovudine results in decreased expression of LAMP2 protein

NCBI chr X:120,426,148...120,469,349
Ensembl chr X:120,426,148...120,469,365

G

lysosomal associated membrane protein 3

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of LAMP3 mRNA

NCBI chr 3:183,122,215...183,163,813
Ensembl chr 3:183,122,215...183,163,839

G

leucine aminopeptidase 3

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of LAP3 mRNA

NCBI chr 4:17,577,198...17,607,970
Ensembl chr 4:17,577,198...17,607,972

G

lymphoid enhancer binding factor 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEF1 mRNA

NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956

G

leptin

decreases expression
multiple interactions

Zidovudine results in decreased expression of LEP protein
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA

PMID:16931933 PMID:17668557

NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629

G

galectin 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of LGALS1 mRNA

NCBI chr22:37,675,636...37,679,802
Ensembl chr22:37,675,636...37,679,802

G

galectin 9

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of LGALS9 mRNA

NCBI chr17:27,631,188...27,649,560
Ensembl chr17:27,629,798...27,649,560

G

leukocyte immunoglobulin like receptor A1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRA1 mRNA

NCBI chr19:54,593,632...54,602,381
Ensembl chr19:54,593,582...54,602,381

G

leukocyte immunoglobulin like receptor B3

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRB3 mRNA

NCBI chr19:54,216,278...54,223,007
Ensembl chr19:54,216,278...54,223,506

G

leukocyte immunoglobulin like receptor B4

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of LILRB4 mRNA

NCBI chr19:54,662,985...54,668,718
Ensembl chr19:54,643,889...54,670,359

G

lipase E, hormone sensitive type

affects expression

Zidovudine affects the expression of LIPE mRNA

NCBI chr19:42,401,514...42,427,388
Ensembl chr19:42,401,514...42,427,388

G

lon peptidase 1, mitochondrial

affects expression

Zidovudine affects the expression of LONP1 protein

NCBI chr19:5,691,834...5,720,452
Ensembl chr19:5,691,834...5,720,572

G

lipoprotein lipase

decreases expression
multiple interactions
affects expression

Zidovudine results in decreased expression of LPL mRNA
[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LPL mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of LPL mRNA
Zidovudine affects the expression of LPL mRNA

PMID:11741158 PMID:16894629 PMID:20032539

NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259

G

lymphocyte antigen 6 family member E

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of LY6E mRNA

NCBI chr 8:143,018,529...143,022,409
Ensembl chr 8:143,017,982...143,023,832

G

mitogen-activated protein kinase 8

increases phosphorylation

Zidovudine results in increased phosphorylation of MAPK8 protein

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

methionyl-tRNA synthetase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of MARS1 mRNA

NCBI chr12:57,488,068...57,516,652
Ensembl chr12:57,475,445...57,517,569

G

MDM2 proto-oncogene

increases expression

Zidovudine results in increased expression of MDM2 protein

NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544

G

malic enzyme 1

multiple interactions
decreases expression

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA; [Zidovudine co-treated with Lamivudine] affects the expression of ME1 mRNA
Zidovudine results in decreased expression of ME1 mRNA

NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051

G

mitochondrial fission factor

multiple interactions

[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of MFF protein

NCBI chr 2:227,325,251...227,357,836
Ensembl chr 2:227,325,151...227,357,833

G

mitofusin 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of MFN1 mRNA

NCBI chr 3:179,347,709...179,394,936
Ensembl chr 3:179,347,709...179,394,936

G

mitofusin 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of MFN2 mRNA

NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211

G

MGAT4 family member C

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MGAT4C mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MGAT4C mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of MGAT4C mRNA

NCBI chr12:85,955,667...86,839,000
Ensembl chr12:85,955,666...86,838,904

G

matrix metallopeptidase 2

multiple interactions

Zidovudine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; Zidovudine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]; Zidovudine inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP2 protein]

NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691

G

matrix metallopeptidase 9

multiple interactions

Zidovudine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Zidovudine inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Zidovudine inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP9 protein]

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

methylmalonyl-CoA mutase

affects expression
increases expression

Zidovudine affects the expression of MMUT mRNA mutant form; Zidovudine affects the expression of MMUT protein mutant form
Zidovudine results in increased expression of MMUT mRNA; Zidovudine results in increased expression of MMUT protein

PMID:19199343 PMID:19427250

NCBI chr 6:49,430,360...49,463,253
Ensembl chr 6:49,430,360...49,463,253

G

myeloid cell nuclear differentiation antigen

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of MNDA mRNA

NCBI chr 1:158,831,351...158,849,502
Ensembl chr 1:158,831,351...158,849,506

G

Mov10 RNA helicase

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of MOV10 mRNA

NCBI chr 1:112,674,439...112,700,739
Ensembl chr 1:112,673,141...112,700,756

G

major histocompatibility complex, class I-related

affects expression

Zidovudine affects the expression of MR1 mRNA

NCBI chr 1:181,033,387...181,061,938
Ensembl chr 1:181,033,374...181,061,938

G

melanocortin 2 receptor accessory protein

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of MRAP mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of MRAP mRNA

NCBI chr21:32,291,813...32,314,784
Ensembl chr21:32,291,813...32,314,784

G

mitochondrially encoded ATP synthase membrane subunit 6

increases expression

Zidovudine results in increased expression of ATP6 mRNA

NCBI chr MT:8,527...9,207
Ensembl chr MT:8,527...9,207

G

mitochondrially encoded cytochrome c oxidase I

increases expression
decreases expression
multiple interactions

Zidovudine results in increased expression of COX1 mRNA
Zidovudine results in decreased expression of COX1 protein
[Zidovudine co-treated with Lamivudine] results in decreased expression of COX1 mRNA; Uridine inhibits the reaction [Zidovudine results in decreased expression of COX1 protein]

PMID:7528833 PMID:17526437 PMID:18163507 PMID:18313992 PMID:20032772 More...

NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445

G

mitochondrially encoded cytochrome c oxidase II

decreases expression
multiple interactions
increases expression

Zidovudine results in decreased expression of COX2 protein
[Zidovudine co-treated with Lamivudine] results in decreased expression of COX2 mRNA
Zidovudine results in increased expression of COX2 mRNA

PMID:7807166 PMID:10912924 PMID:16894629 PMID:18313992

NCBI chr MT:7,586...8,269
Ensembl chr MT:7,586...8,269

G

mitochondrially encoded cytochrome c oxidase III

affects expression
multiple interactions
decreases expression
increases expression

Zidovudine affects the expression of COX3 mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of COX3 mRNA
Zidovudine results in decreased expression of COX3 mRNA
Zidovudine results in increased expression of COX3 mRNA

PMID:8828681 PMID:9799652 PMID:16894629 PMID:17526437 PMID:18313992 More...

NCBI chr MT:9,207...9,990
Ensembl chr MT:9,207...9,990

G

mitochondrially encoded cytochrome b

affects expression
decreases expression
increases expression

Zidovudine affects the expression of CYTB mRNA
Zidovudine results in decreased expression of CYTB mRNA
Zidovudine results in increased expression of CYTB mRNA

PMID:1715447 PMID:7528833 PMID:20032539

NCBI chr MT:14,747...15,887
Ensembl chr MT:14,747...15,887

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1

increases expression

Zidovudine results in increased expression of ND1 mRNA

NCBI chr MT:3,307...4,262
Ensembl chr MT:3,307...4,262

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2

increases expression
multiple interactions

Zidovudine results in increased expression of ND2 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of ND2 mRNA

PMID:16894629 PMID:18313992

NCBI chr MT:4,470...5,511
Ensembl chr MT:4,470...5,511

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4

increases expression
affects expression

Zidovudine results in increased expression of ND4 mRNA
Zidovudine affects the expression of ND4 mRNA

PMID:16894629 PMID:20032539

NCBI chr MT:10,760...12,137
Ensembl chr MT:10,760...12,137

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5

increases expression
multiple interactions

Zidovudine results in increased expression of ND5 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of ND5 mRNA

PMID:16894629 PMID:17526437 PMID:18313992

NCBI chr MT:12,337...14,148
Ensembl chr MT:12,337...14,148

G

metallothionein 1G

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of MT1G mRNA

NCBI chr16:56,666,730...56,668,065
Ensembl chr16:56,666,730...56,668,065

G

metallothionein 2A

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of MT2A mRNA

NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of MTHFD2 mRNA

NCBI chr 2:74,198,615...74,217,565
Ensembl chr 2:74,186,172...74,217,565

G

mechanistic target of rapamycin kinase

increases phosphorylation

Zidovudine results in increased phosphorylation of MTOR protein

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

mevalonate diphosphate decarboxylase

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of MVD mRNA

NCBI chr16:88,651,940...88,663,091
Ensembl chr16:88,651,935...88,663,161

G

MX dynamin like GTPase 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of MX1 mRNA

NCBI chr21:41,420,558...41,459,214
Ensembl chr21:41,420,020...41,470,071

G

MX dynamin like GTPase 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of MX2 mRNA

NCBI chr21:41,362,027...41,409,393
Ensembl chr21:41,361,999...41,409,393

G

myosin heavy chain 7

increases expression

Zidovudine results in increased expression of MYH7 mRNA; Zidovudine results in increased expression of MYH7 protein

NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660

G

myogenic differentiation 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of MYOD1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MYOD1 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of MYOD1 mRNA

NCBI chr11:17,719,571...17,722,136
Ensembl chr11:17,719,571...17,722,136

G

nucleosome assembly protein 1 like 5

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NAP1L5 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NAP1L5 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of NAP1L5 mRNA

NCBI chr 4:88,695,913...88,697,829
Ensembl chr 4:88,695,913...88,697,829

G

N-acetyltransferase 2

decreases expression
multiple interactions

Zidovudine results in decreased expression of NAT2 mRNA
[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA]

NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218

G

NDUFA4 mitochondrial complex associated

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFA4 mRNA

NCBI chr 7:10,931,943...10,940,153
Ensembl chr 7:10,931,943...10,940,153

G

NADH:ubiquinone oxidoreductase subunit A6

increases expression

Zidovudine results in increased expression of NDUFA6 mRNA

NCBI chr22:42,085,526...42,090,772
Ensembl chr22:42,085,526...42,090,884

G

NADH:ubiquinone oxidoreductase subunit A9

increases expression

Zidovudine results in increased expression of NDUFA9 mRNA

NCBI chr12:4,649,114...4,694,317
Ensembl chr12:4,649,095...4,694,317

G

NADH:ubiquinone oxidoreductase subunit AB1

increases expression
multiple interactions

Zidovudine results in increased expression of NDUFAB1 mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFAB1 mRNA

PMID:16894629 PMID:18313992

NCBI chr16:23,581,014...23,596,316
Ensembl chr16:23,581,014...23,596,316

G

NADH:ubiquinone oxidoreductase complex assembly factor 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFAF1 mRNA

NCBI chr15:41,387,353...41,403,026
Ensembl chr15:41,387,218...41,409,403

G

NADH:ubiquinone oxidoreductase subunit B11

multiple interactions

Zidovudine inhibits the reaction [Cyclic AMP results in increased phosphorylation of NDUFB11 protein]

NCBI chr X:47,142,216...47,145,491
Ensembl chr X:47,142,071...47,145,466

G

NADH:ubiquinone oxidoreductase subunit B3

increases expression
multiple interactions

Zidovudine results in increased expression of NDUFB3 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of NDUFB3 mRNA

PMID:16894629 PMID:18313992

NCBI chr 2:201,072,001...201,085,750
Ensembl chr 2:201,071,433...201,085,750

G

NADH:ubiquinone oxidoreductase subunit B5

increases expression
multiple interactions

Zidovudine results in increased expression of NDUFB5 mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of NDUFB5 mRNA

PMID:16894629 PMID:18313992

NCBI chr 3:179,604,794...179,627,647
Ensembl chr 3:179,604,690...179,627,647

G

NADH:ubiquinone oxidoreductase subunit B6

increases expression

Zidovudine results in increased expression of NDUFB6 mRNA

NCBI chr 9:32,553,001...32,573,159
Ensembl chr 9:32,553,001...32,573,184

G

NADH:ubiquinone oxidoreductase subunit B9

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFB9 mRNA

NCBI chr 8:124,539,123...124,549,979
Ensembl chr 8:124,539,101...124,580,648

G

NADH:ubiquinone oxidoreductase subunit C1

increases expression
multiple interactions

Zidovudine results in increased expression of NDUFC1 mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFC1 mRNA

PMID:16894629 PMID:18313992

NCBI chr 4:139,289,917...139,302,551
Ensembl chr 4:139,266,880...139,302,551

G

NADH:ubiquinone oxidoreductase core subunit S1

increases expression
multiple interactions

Zidovudine results in increased expression of NDUFS1 mRNA
[Zidovudine co-treated with Lamivudine] results in increased expression of NDUFS1 mRNA

PMID:16894629 PMID:18313992

NCBI chr 2:206,114,817...206,159,444
Ensembl chr 2:206,114,817...206,159,509

G

NADH:ubiquinone oxidoreductase core subunit S2

decreases expression

Zidovudine results in decreased expression of NDUFS2 mRNA

NCBI chr 1:161,197,417...161,214,395
Ensembl chr 1:161,197,104...161,214,723

G

NADH:ubiquinone oxidoreductase subunit S5

increases expression

Zidovudine results in increased expression of NDUFS5 mRNA

NCBI chr 1:39,026,350...39,034,615
Ensembl chr 1:39,026,318...39,034,636

G

NADH:ubiquinone oxidoreductase subunit S6

increases expression

Zidovudine results in increased expression of NDUFS6 mRNA

NCBI chr 5:1,801,407...1,816,048
Ensembl chr 5:1,801,407...1,816,048

G

NADH:ubiquinone oxidoreductase core subunit V1

decreases expression

Zidovudine results in decreased expression of NDUFV1 mRNA

NCBI chr11:67,606,936...67,612,554
Ensembl chr11:67,605,653...67,612,554

G

nexilin F-actin binding protein

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of NEXN mRNA

NCBI chr 1:77,888,624...77,943,895
Ensembl chr 1:77,888,513...77,943,895

G

nuclear factor, erythroid 2

decreases activity
decreases expression

Zidovudine results in decreased activity of NFE2 protein
Zidovudine results in decreased expression of NFE2 mRNA

NCBI chr12:54,292,111...54,301,015
Ensembl chr12:54,292,111...54,301,015

G

NFE2 like bZIP transcription factor 2

increases expression

Zidovudine results in increased expression of NFE2L2 protein

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

niban apoptosis regulator 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of NIBAN1 mRNA

NCBI chr 1:184,791,032...184,974,508
Ensembl chr 1:184,790,724...184,974,508

G

nocturnin

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of NOCT mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of NOCT mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of NOCT mRNA

NCBI chr 4:139,015,781...139,045,939
Ensembl chr 4:139,015,781...139,045,939

G

nitric oxide synthase 3

multiple interactions
decreases phosphorylation

coenzyme Q10 inhibits the reaction [Zidovudine results in decreased phosphorylation of NOS3 protein]

NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588

G

natriuretic peptide A

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NPPA mRNA
Zidovudine results in increased expression of NPPA mRNA

PMID:10701688 PMID:11706060

NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345

G

NAD(P)H quinone dehydrogenase 1

increases expression

Zidovudine results in increased expression of NQO1 mRNA

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

nuclear receptor subfamily 3 group C member 1

affects expression

Zidovudine affects the expression of NR3C1 mRNA

NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512

G

nuclear respiratory factor 1

increases expression

Zidovudine results in increased expression of NRF1 mRNA

NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082

G

5'-nucleotidase, cytosolic IIIA

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of NT5C3A mRNA

NCBI chr 7:33,014,113...33,062,776
Ensembl chr 7:33,014,130...33,062,796

G

negative regulator of ubiquitin like proteins 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of NUB1 mRNA

NCBI chr 7:151,341,812...151,378,449
Ensembl chr 7:151,341,772...151,378,449

G

NUF2 component of NDC80 kinetochore complex

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of NUF2 mRNA

NCBI chr 1:163,321,954...163,355,759
Ensembl chr 1:163,266,576...163,355,764

G

nucleoporin 210

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of NUP210 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NUP210 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of NUP210 mRNA

NCBI chr 3:13,316,235...13,420,322
Ensembl chr 3:13,316,235...13,420,322

G

nucleoredoxin like 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of NXNL2 mRNA

NCBI chr 9:88,535,178...88,584,510
Ensembl chr 9:88,534,033...88,584,274

G

2'-5'-oligoadenylate synthetase 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS1 mRNA

NCBI chr12:112,906,962...112,933,219
Ensembl chr12:112,905,856...112,933,219

G

2'-5'-oligoadenylate synthetase 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS2 mRNA

NCBI chr12:112,978,519...113,011,723
Ensembl chr12:112,978,395...113,011,723

G

2'-5'-oligoadenylate synthetase 3

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of OAS3 mRNA

NCBI chr12:112,938,474...112,973,251
Ensembl chr12:112,938,051...112,976,460

G

ornithine decarboxylase antizyme 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of OAZ3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of OAZ3 mRNA

NCBI chr 1:151,762,969...151,771,330
Ensembl chr 1:151,762,899...151,771,334

G

O-linked N-acetylglucosamine (GlcNAc) transferase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of OGT mRNA

NCBI chr X:71,533,104...71,575,892
Ensembl chr X:71,533,087...71,575,892

G

OPA1 mitochondrial dynamin like GTPase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of OPA1 mRNA
[DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 mRNA; [DTYMK protein affects the susceptibility to Zidovudine] which affects the expression of OPA1 protein

PMID:18313992 PMID:28683400

NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811

G

opioid related nociceptin receptor 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of OPRL1 mRNA

NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,080,082...64,100,643

G

poly(ADP-ribose) polymerase family member 9

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of PARP9 mRNA

NCBI chr 3:122,527,924...122,564,784
Ensembl chr 3:122,527,924...122,564,577

G

poly(rC) binding protein 4

increases expression

Zidovudine results in increased expression of PCBP4 mRNA

NCBI chr 3:51,957,454...51,967,466
Ensembl chr 3:51,957,454...51,974,016

G

protocadherin related 15

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PCDH15 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PCDH15 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of PCDH15 mRNA

NCBI chr10:53,802,771...55,627,942
Ensembl chr10:53,802,771...55,627,942

G

phosphoenolpyruvate carboxykinase 2, mitochondrial

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of PCK2 mRNA

NCBI chr14:24,094,171...24,104,125
Ensembl chr14:24,094,053...24,110,598

G

proliferating cell nuclear antigen

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of PCNA mRNA

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

G

phosphatidylethanolamine binding protein 1

decreases expression

Zidovudine results in decreased expression of PEBP1 mRNA

NCBI chr12:118,136,124...118,145,584
Ensembl chr12:118,136,124...118,145,584

G

platelet factor 4

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of PF4 mRNA

NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PFKFB3 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PFKFB3 mRNA

NCBI chr10:6,144,921...6,326,637
Ensembl chr10:6,144,934...6,254,644

G

post-GPI attachment to proteins 6

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of PGAP6 mRNA

NCBI chr16:370,788...386,979
Ensembl chr16:370,788...387,113

G

progesterone receptor

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of PGR mRNA

NCBI chr11:101,029,624...101,129,813
Ensembl chr11:101,029,624...101,129,813

G

PHD finger protein 6

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PHF6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PHF6 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of PHF6 mRNA

NCBI chr X:134,373,312...134,428,790
Ensembl chr X:134,373,288...134,428,791

G

p53-induced death domain protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIDD1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIDD1 mRNA

NCBI chr11:799,184...809,501
Ensembl chr11:799,179...809,753

G

piercer of microtubule wall 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of PIERCE1 mRNA

NCBI chr 9:135,495,181...135,499,869
Ensembl chr 9:135,495,181...135,501,734

G

phosphoinositide-3-kinase adaptor protein 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of PIK3AP1 mRNA

NCBI chr10:96,593,315...96,720,514
Ensembl chr10:96,593,315...96,720,514

G

piwi like RNA-mediated gene silencing 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PIWIL2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIWIL2 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of PIWIL2 mRNA

NCBI chr 8:22,275,316...22,357,568
Ensembl chr 8:22,275,316...22,357,568

G

protein kinase, membrane associated tyrosine/threonine 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of PKMYT1 mRNA

NCBI chr16:2,972,808...2,980,446
Ensembl chr16:2,968,024...2,980,479

G

phospholipid scramblase 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of PLSCR1 mRNA

NCBI chr 3:146,515,180...146,544,607
Ensembl chr 3:146,515,180...146,544,856

G

polynucleotide kinase 3'-phosphatase

increases expression

Zidovudine results in increased expression of PNKP mRNA

NCBI chr19:49,861,204...49,867,576
Ensembl chr19:49,859,882...49,878,351

G

cytochrome p450 oxidoreductase

decreases expression
multiple interactions

Zidovudine results in decreased expression of POR mRNA
[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA]

NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855

G

porcupine O-acyltransferase

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PPN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PPN mRNA

NCBI chr X:48,508,992...48,520,814
Ensembl chr X:48,508,959...48,520,814

G

POU class 5 homeobox 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of POU5F1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of POU5F1 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of POU5F1 mRNA

NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731

G

peroxisome proliferator activated receptor gamma

decreases expression

Zidovudine results in decreased expression of PPARG mRNA; Zidovudine results in decreased expression of PPARG protein

PMID:15722030 PMID:17926646

NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356

G

PR/SET domain 1

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of PRDM1 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PRDM1 mRNA

NCBI chr 6:105,992,690...106,109,938
Ensembl chr 6:105,993,463...106,109,939

G

phosphoserine aminotransferase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of PSAT1 mRNA

NCBI chr 9:78,297,125...78,330,093
Ensembl chr 9:78,297,125...78,330,093

G

prostaglandin-endoperoxide synthase 2

decreases expression

Zidovudine results in decreased expression of PTGS2 protein

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

RAB17, member RAS oncogene family

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of RAB17 mRNA

NCBI chr 2:237,574,326...237,590,734
Ensembl chr 2:237,574,322...237,601,614

G

RAB3B, member RAS oncogene family

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of RAB3B mRNA

NCBI chr 1:51,907,956...51,990,700
Ensembl chr 1:51,907,956...51,990,700

G

Rab9 effector protein with kelch motifs

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of RABEPK mRNA

NCBI chr 9:125,200,542...125,234,161
Ensembl chr 9:125,200,542...125,234,161

G

Ras association domain family member 7

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of RASSF7 mRNA

NCBI chr11:560,970...564,025
Ensembl chr11:560,404...564,025

G

RB transcriptional corepressor like 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of RBL1 mRNA

NCBI chr20:36,996,349...37,095,997
Ensembl chr20:36,996,349...37,095,997

G

RB transcriptional corepressor like 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of RBL2 mRNA

NCBI chr16:53,434,471...53,491,648
Ensembl chr16:53,433,977...53,491,648

G

receptor accessory protein 6

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of REEP6 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of REEP6 mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of REEP6 mRNA

NCBI chr19:1,491,181...1,497,927
Ensembl chr19:1,491,166...1,497,927

G

REL proto-oncogene, NF-kB subunit

multiple interactions

REL protein results in decreased susceptibility to [Zidovudine co-treated with IFNA1 protein]

NCBI chr 2:60,881,574...60,931,612
Ensembl chr 2:60,881,491...60,931,612

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases expression

2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine inhibits the reaction [Zidovudine results in increased expression of RELA protein]; glutapyrone inhibits the reaction [Zidovudine results in increased expression of RELA protein]; tauropyrone inhibits the reaction [Zidovudine results in increased expression of RELA protein]
Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Hydralazine inhibits the reaction [Acrolein promotes the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]]; Hydralazine inhibits the reaction [Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]]; Zidovudine promotes the reaction [Acrolein promotes the reaction [RELA protein binds to FASLG promoter]]; Zidovudine promotes the reaction [RELA protein binds to FASLG promoter]

PMID:18801031 PMID:27238871

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

regulator of G protein signaling 6

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of RGS6 mRNA

NCBI chr14:71,867,335...72,630,029
Ensembl chr14:71,932,429...72,566,530

G

receptor interacting serine/threonine kinase 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of RIPK2 mRNA

NCBI chr 8:89,757,816...89,791,064
Ensembl chr 8:89,757,806...89,791,064

G

ring finger protein 151

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of RNF151 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of RNF151 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of RNF151 mRNA

NCBI chr16:1,966,856...1,968,949
Ensembl chr16:1,966,823...1,968,975

G

ring finger protein 213

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of RNF213 mRNA

NCBI chr17:80,260,852...80,398,794
Ensembl chr17:80,260,852...80,398,794

G

replication protein A1

increases expression

Zidovudine results in increased expression of RPA1 mRNA

NCBI chr17:1,830,005...1,900,082
Ensembl chr17:1,829,702...1,900,082

G

RPA interacting protein

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of RPAIN mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of RPAIN mRNA; [Zidovudine co-treated with Lamivudine] results in decreased expression of RPAIN mRNA

NCBI chr17:5,420,182...5,432,877
Ensembl chr17:5,419,641...5,432,877

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

Zidovudine results in increased expression of RRM2B mRNA

NCBI chr 8:102,204,501...102,238,961
Ensembl chr 8:102,204,502...102,238,961

G

radical S-adenosyl methionine domain containing 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of RSAD2 mRNA

NCBI chr 2:6,865,885...6,898,239
Ensembl chr 2:6,865,557...6,898,239

G

S100 calcium binding protein A8

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of S100A8 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of S100A8 mRNA

NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073

G

sterile alpha motif domain containing 9 like

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SAMD9L mRNA

NCBI chr 7:93,130,056...93,148,385
Ensembl chr 7:93,130,056...93,148,385

G

suppressor APC domain containing 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of SAPCD2 mRNA

NCBI chr 9:137,062,127...137,070,557
Ensembl chr 9:137,062,127...137,070,557

G

SLP adaptor and CSK interacting membrane protein

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SCIMP mRNA

NCBI chr17:5,208,920...5,234,860
Ensembl chr17:5,208,920...5,234,860

G

succinate dehydrogenase complex iron sulfur subunit B

decreases expression
multiple interactions

Zidovudine results in decreased expression of SDHB mRNA
[Zidovudine co-treated with Lamivudine] results in decreased expression of SDHB mRNA

PMID:16894629 PMID:18313992

NCBI chr 1:17,018,722...17,054,032
Ensembl chr 1:17,018,664...17,054,151

G

succinate dehydrogenase complex subunit D

increases expression

Zidovudine results in increased expression of SDHD mRNA

NCBI chr11:112,086,873...112,095,794
Ensembl chr11:112,086,824...112,120,016

G

serine incorporator 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of SERINC1 mRNA

NCBI chr 6:122,443,351...122,471,807
Ensembl chr 6:122,443,351...122,471,807

G

serpin family G member 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SERPING1 mRNA

NCBI chr11:57,597,685...57,614,848
Ensembl chr11:57,597,387...57,619,171

G

sideroflexin 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN1 mRNA

NCBI chr 5:175,478,560...175,529,742
Ensembl chr 5:175,477,062...175,529,742

G

sideroflexin 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN2 mRNA

NCBI chr10:102,714,636...102,743,492
Ensembl chr10:102,714,538...102,743,492

G

sideroflexin 4

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SFXN4 mRNA

NCBI chr10:119,140,767...119,165,714
Ensembl chr10:119,140,767...119,165,714

G

sphingosine-1-phosphate phosphatase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SGPP1 mRNA

NCBI chr14:63,684,216...63,728,065
Ensembl chr14:63,684,216...63,728,065

G

shiftless antiviral inhibitor of ribosomal frameshifting

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SHFL mRNA

NCBI chr19:10,086,317...10,093,243
Ensembl chr19:10,086,122...10,093,252

G

sialic acid binding Ig like lectin 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SIGLEC1 mRNA

NCBI chr20:3,686,970...3,712,600
Ensembl chr20:3,686,970...3,712,600

G

sirtuin 3

increases expression

Zidovudine results in increased expression of SIRT3 protein

NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931

G

solute carrier family 10 member 3

increases expression

Zidovudine results in increased expression of SLC10A3 mRNA

NCBI chr X:154,487,311...154,490,629
Ensembl chr X:154,487,306...154,490,690

G

solute carrier family 12 member 3

decreases expression

Zidovudine results in decreased expression of SLC12A3 mRNA

NCBI chr16:56,865,207...56,915,850
Ensembl chr16:56,865,207...56,915,850

G

solute carrier family 12 member 4

increases expression

Zidovudine results in increased expression of SLC12A4 mRNA

NCBI chr16:67,943,474...67,968,694
Ensembl chr16:67,943,474...67,969,601

G

solute carrier family 12 member 9

increases expression

Zidovudine results in increased expression of SLC12A9 mRNA

NCBI chr 7:100,826,869...100,867,012
Ensembl chr 7:100,826,820...100,867,010

G

solute carrier family 13 member 3

increases expression
decreases expression

Zidovudine results in increased expression of SLC13A3 mRNA
Zidovudine results in decreased expression of SLC13A3 mRNA

NCBI chr20:46,557,828...46,684,485
Ensembl chr20:46,557,823...46,684,467

G

solute carrier family 13 member 5

decreases expression
increases expression

Zidovudine results in decreased expression of SLC13A5 mRNA
Zidovudine results in increased expression of SLC13A5 mRNA

NCBI chr17:6,684,719...6,713,369
Ensembl chr17:6,684,719...6,713,377

G

solute carrier family 16 member 1

decreases expression

Zidovudine results in decreased expression of SLC16A1 mRNA

NCBI chr 1:112,911,847...112,956,196
Ensembl chr 1:112,911,847...112,957,593

G

solute carrier family 16 member 2

increases expression

Zidovudine results in increased expression of SLC16A2 mRNA

NCBI chr X:74,421,493...74,533,916
Ensembl chr X:74,421,493...74,533,917

G

solute carrier family 16 member 3

decreases expression

Zidovudine results in decreased expression of SLC16A3 mRNA

NCBI chr17:82,217,934...82,240,086
Ensembl chr17:82,217,934...82,261,129

G

solute carrier family 16 member 4

increases expression

Zidovudine results in increased expression of SLC16A4 mRNA

NCBI chr 1:110,362,857...110,391,026
Ensembl chr 1:110,362,851...110,391,082

G

solute carrier family 16 member 6

decreases expression
increases expression

Zidovudine results in decreased expression of SLC16A6 mRNA
Zidovudine results in increased expression of SLC16A6 mRNA

NCBI chr17:68,267,026...68,291,479
Ensembl chr17:68,267,026...68,291,267

G

solute carrier family 17 member 2

decreases expression

Zidovudine results in decreased expression of SLC17A2 mRNA

NCBI chr 6:25,912,754...25,930,691
Ensembl chr 6:25,912,754...25,930,691

G

solute carrier family 17 member 8

increases expression

Zidovudine results in increased expression of SLC17A8 mRNA

NCBI chr12:100,357,074...100,422,055
Ensembl chr12:100,357,074...100,422,055

G

solute carrier family 19 member 2

decreases expression

Zidovudine results in decreased expression of SLC19A2 mRNA

NCBI chr 1:169,463,909...169,485,970
Ensembl chr 1:169,463,909...169,485,944

G

solute carrier family 19 member 3

decreases expression

Zidovudine results in decreased expression of SLC19A3 mRNA

NCBI chr 2:227,683,763...227,718,028
Ensembl chr 2:227,683,763...227,718,028

G

solute carrier family 1 member 1

increases expression

Zidovudine results in increased expression of SLC1A1 mRNA

NCBI chr 9:4,490,468...4,587,469
Ensembl chr 9:4,490,468...4,587,469

G

solute carrier family 1 member 4

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC1A4 mRNA
Zidovudine results in increased expression of SLC1A4 mRNA

PMID:15784690 PMID:24292225

NCBI chr 2:64,988,479...65,023,865
Ensembl chr 2:64,988,477...65,023,865

G

solute carrier family 1 member 5

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC1A5 mRNA

NCBI chr19:46,774,883...46,788,594
Ensembl chr19:46,774,883...46,788,594

G

solute carrier family 20 member 1

decreases expression

Zidovudine results in decreased expression of SLC20A1 mRNA

NCBI chr 2:112,645,939...112,663,825
Ensembl chr 2:112,645,939...112,663,825

G

solute carrier family 20 member 2

increases expression

Zidovudine results in increased expression of SLC20A2 mRNA

NCBI chr 8:42,416,475...42,541,954
Ensembl chr 8:42,416,475...42,541,926

G

solute carrier family 22 member 15

decreases expression

Zidovudine results in decreased expression of SLC22A15 mRNA

NCBI chr 1:115,976,513...116,070,054
Ensembl chr 1:115,976,513...116,070,054

G

solute carrier family 22 member 17

increases expression

Zidovudine results in increased expression of SLC22A17 mRNA

NCBI chr14:23,346,311...23,352,887
Ensembl chr14:23,346,314...23,352,912

G

solute carrier family 22 member 18

increases expression

Zidovudine results in increased expression of SLC22A18 mRNA

NCBI chr11:2,899,691...2,925,246
Ensembl chr11:2,899,721...2,925,246

G

solute carrier family 22 member 23

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC22A23 mRNA

NCBI chr 6:3,268,973...3,457,050
Ensembl chr 6:3,268,962...3,457,050

G

solute carrier family 22 member 4

increases expression

Zidovudine results in increased expression of SLC22A4 mRNA

NCBI chr 5:132,294,394...132,344,190
Ensembl chr 5:132,294,394...132,344,190

G

solute carrier family 22 member 5

increases expression

Zidovudine results in increased expression of SLC22A5 mRNA

NCBI chr 5:132,369,710...132,395,612
Ensembl chr 5:132,369,710...132,395,613

G

solute carrier family 22 member 7

increases uptake
increases expression

SLC22A7 protein results in increased uptake of Zidovudine
Zidovudine results in increased expression of SLC22A7 mRNA

PMID:15901346 PMID:24292225

NCBI chr 6:43,295,714...43,305,538
Ensembl chr 6:43,295,694...43,305,538

G

solute carrier family 22 member 9

decreases expression

Zidovudine results in decreased expression of SLC22A9 mRNA

NCBI chr11:63,369,785...63,410,294
Ensembl chr11:63,369,785...63,410,294

G

solute carrier family 23 member 2

increases expression

Zidovudine results in increased expression of SLC23A2 mRNA

NCBI chr20:4,852,358...5,010,313
Ensembl chr20:4,852,356...5,010,293

G

solute carrier family 24 member 4

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC24A4 mRNA

NCBI chr14:92,322,581...92,501,481
Ensembl chr14:92,322,581...92,501,481

G

solute carrier family 25 member 1

increases expression

Zidovudine results in increased expression of SLC25A1 mRNA

NCBI chr22:19,175,581...19,178,736
Ensembl chr22:19,175,581...19,178,739

G

solute carrier family 25 member 10

increases expression

Zidovudine results in increased expression of SLC25A10 mRNA

NCBI chr17:81,712,284...81,721,012
Ensembl chr17:81,712,236...81,721,016

G

solute carrier family 25 member 11

increases expression

Zidovudine results in increased expression of SLC25A11 mRNA

NCBI chr17:4,937,130...4,940,046
Ensembl chr17:4,937,130...4,940,053

G

solute carrier family 25 member 12

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A12 mRNA

NCBI chr 2:171,783,405...171,894,244
Ensembl chr 2:171,783,405...171,999,859

G

solute carrier family 25 member 15

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A15 mRNA

NCBI chr13:40,789,611...40,812,460
Ensembl chr13:40,789,412...40,812,460

G

solute carrier family 25 member 16

increases expression

Zidovudine results in increased expression of SLC25A16 mRNA

NCBI chr10:68,477,998...68,527,523
Ensembl chr10:68,477,998...68,527,523

G

solute carrier family 25 member 19

multiple interactions

SLC25A19 protein affects the susceptibility to [Zidovudine co-treated with Lamivudine co-treated with Indinavir]
[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A19 mRNA

PMID:15951836 PMID:18313992

NCBI chr17:75,272,992...75,289,433
Ensembl chr17:75,272,981...75,289,510

G

solute carrier family 25 member 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A2 mRNA

NCBI chr 5:141,302,635...141,304,049
Ensembl chr 5:141,302,635...141,304,049

G

solute carrier family 25 member 20

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A20 mRNA
Zidovudine results in increased expression of SLC25A20 mRNA

PMID:18313992 PMID:24292225

NCBI chr 3:48,856,926...48,898,882
Ensembl chr 3:48,856,926...48,898,904

G

solute carrier family 25 member 21

increases expression

Zidovudine results in increased expression of SLC25A21 mRNA

NCBI chr14:36,677,921...37,172,606
Ensembl chr14:36,677,921...37,172,606

G

solute carrier family 25 member 29

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A29 mRNA

NCBI chr14:100,278,567...100,306,444
Ensembl chr14:100,291,116...100,306,547

G

solute carrier family 25 member 3

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of SLC25A3 mRNA

NCBI chr12:98,593,686...98,606,367
Ensembl chr12:98,593,591...98,606,379

G

solute carrier family 25 member 4

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC25A4 mRNA

NCBI chr 4:185,143,266...185,150,382
Ensembl chr 4:185,143,266...185,150,382

G

solute carrier family 26 member 1

increases expression

Zidovudine results in increased expression of SLC26A1 mRNA

NCBI chr 4:978,991...993,404
Ensembl chr 4:979,073...993,440

G

solute carrier family 26 member 11

increases expression

Zidovudine results in increased expression of SLC26A11 mRNA

NCBI chr17:80,220,427...80,253,500
Ensembl chr17:80,219,699...80,253,500

G

solute carrier family 26 member 2

increases expression

Zidovudine results in increased expression of SLC26A2 mRNA

NCBI chr 5:149,960,758...149,987,400
Ensembl chr 5:149,960,758...149,993,455

G

solute carrier family 26 member 3

decreases expression

Zidovudine results in decreased expression of SLC26A3 mRNA

NCBI chr 7:107,765,469...107,803,223
Ensembl chr 7:107,765,467...107,803,225

G

solute carrier family 26 member 9

increases expression

Zidovudine results in increased expression of SLC26A9 mRNA

NCBI chr 1:205,913,052...205,943,456
Ensembl chr 1:205,913,048...205,943,460

G

solute carrier family 27 member 2

increases expression

Zidovudine results in increased expression of SLC27A2 mRNA

NCBI chr15:50,182,196...50,236,385
Ensembl chr15:50,182,196...50,236,385

G

solute carrier family 28 member 1

affects transport
multiple interactions
increases uptake

SLC28A1 protein affects the transport of Zidovudine
Zidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]; Zidovudine promotes the reaction [SLC28A1 protein results in increased export of Uridine]
SLC28A1 protein results in increased uptake of Zidovudine

PMID:8027026 PMID:8700147 PMID:8713072 PMID:9124315

NCBI chr15:84,884,662...84,975,649
Ensembl chr15:84,884,654...84,945,798

G

solute carrier family 28 member 3

increases expression

Zidovudine results in increased expression of SLC28A3 mRNA

NCBI chr 9:84,275,457...84,368,727
Ensembl chr 9:84,275,457...84,340,758

G

solute carrier family 29 member 1 (Augustine blood group)

increases expression

Zidovudine results in increased expression of SLC29A1 mRNA

NCBI chr 6:44,219,615...44,234,142
Ensembl chr 6:44,219,553...44,234,142

G

solute carrier family 29 member 3

affects transport
increases expression

SLC29A3 protein affects the transport of Zidovudine
Zidovudine results in increased expression of SLC29A3 mRNA

PMID:19164483 PMID:24292225

NCBI chr10:71,319,259...71,381,423
Ensembl chr10:71,319,259...71,381,423

G

solute carrier family 2 member 1

decreases expression

Zidovudine results in decreased expression of SLC2A1 mRNA

NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893

G

solute carrier family 2 member 10

decreases expression

Zidovudine results in decreased expression of SLC2A10 mRNA

NCBI chr20:46,708,320...46,736,347
Ensembl chr20:46,709,649...46,736,347

G

solute carrier family 2 member 11

increases expression

Zidovudine results in increased expression of SLC2A11 mRNA

NCBI chr22:23,856,934...23,886,312
Ensembl chr22:23,856,703...23,886,312

G

solute carrier family 2 member 14

decreases expression

Zidovudine results in decreased expression of SLC2A14 mRNA

NCBI chr12:7,812,514...7,891,196
Ensembl chr12:7,812,512...7,891,148

G

solute carrier family 2 member 3

decreases expression

Zidovudine results in decreased expression of SLC2A3 mRNA

NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...8,019,007

G

solute carrier family 2 member 4

affects expression

Zidovudine affects the expression of SLC2A4 mRNA

NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257

G

solute carrier family 2 member 6

increases expression

Zidovudine results in increased expression of SLC2A6 mRNA

NCBI chr 9:133,471,094...133,479,099
Ensembl chr 9:133,471,094...133,479,127

G

solute carrier family 2 member 8

increases expression

Zidovudine results in increased expression of SLC2A8 mRNA

NCBI chr 9:127,397,169...127,407,898
Ensembl chr 9:127,397,138...127,408,424

G

solute carrier family 30 member 1

increases expression

Zidovudine results in increased expression of SLC30A1 mRNA

NCBI chr 1:211,571,568...211,579,161
Ensembl chr 1:211,571,568...211,579,161

G

solute carrier family 30 member 3

increases expression

Zidovudine results in increased expression of SLC30A3 mRNA

NCBI chr 2:27,253,684...27,275,817
Ensembl chr 2:27,253,684...27,275,817

G

solute carrier family 30 member 7

increases expression

Zidovudine results in increased expression of SLC30A7 mRNA

NCBI chr 1:100,896,090...100,996,078
Ensembl chr 1:100,896,076...100,981,757

G

solute carrier family 30 member 9

increases expression

Zidovudine results in increased expression of SLC30A9 mRNA

NCBI chr 4:41,990,530...42,090,461
Ensembl chr 4:41,990,502...42,090,461

G

solute carrier family 31 member 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC31A1 mRNA

NCBI chr 9:113,221,544...113,264,492
Ensembl chr 9:113,221,544...113,264,492

G

solute carrier family 31 member 2

increases expression

Zidovudine results in increased expression of SLC31A2 mRNA

NCBI chr 9:113,151,007...113,164,140
Ensembl chr 9:113,150,976...113,164,140

G

solute carrier family 35 member A4

increases expression

Zidovudine results in increased expression of SLC35A4 mRNA

NCBI chr 5:140,564,828...140,569,100
Ensembl chr 5:140,564,819...140,569,100

G

solute carrier family 35 member B3

increases expression

Zidovudine results in increased expression of SLC35B3 mRNA

NCBI chr 6:8,411,435...8,435,567
Ensembl chr 6:8,411,435...8,435,561

G

solute carrier family 35 member B4

increases expression

Zidovudine results in increased expression of SLC35B4 mRNA

NCBI chr 7:134,289,332...134,320,338
Ensembl chr 7:134,289,332...134,316,930

G

solute carrier family 35 member D1

increases expression

Zidovudine results in increased expression of SLC35D1 mRNA

NCBI chr 1:66,972,976...67,054,148
Ensembl chr 1:66,999,350...67,054,148

G

solute carrier family 35 member E2A (pseudogene)

increases expression

Zidovudine results in increased expression of SLC35E2A mRNA

NCBI chr 1:1,727,385...1,746,070
Ensembl chr 1:1,734,690...1,739,557

G

solute carrier family 35 member F2

increases expression

Zidovudine results in increased expression of SLC35F2 mRNA

NCBI chr11:107,790,991...107,858,787
Ensembl chr11:107,790,991...107,928,293

G

solute carrier family 37 member 1

increases expression

Zidovudine results in increased expression of SLC37A1 mRNA

NCBI chr21:42,499,622...42,581,426
Ensembl chr21:42,496,008...42,581,440

G

solute carrier family 37 member 2

increases expression

Zidovudine results in increased expression of SLC37A2 mRNA

NCBI chr11:125,063,305...125,090,516
Ensembl chr11:125,063,302...125,090,516

G

solute carrier family 38 member 2

decreases expression

Zidovudine results in decreased expression of SLC38A2 mRNA

NCBI chr12:46,358,188...46,372,773
Ensembl chr12:46,358,188...46,372,773

G

solute carrier family 38 member 3

increases expression

Zidovudine results in increased expression of SLC38A3 mRNA

NCBI chr 3:50,205,271...50,221,486
Ensembl chr 3:50,205,246...50,221,486

G

solute carrier family 38 member 4

decreases expression

Zidovudine results in decreased expression of SLC38A4 mRNA

NCBI chr12:46,764,761...46,832,431
Ensembl chr12:46,764,761...46,832,408

G

solute carrier family 38 member 5

decreases expression

Zidovudine results in decreased expression of SLC38A5 mRNA

NCBI chr X:48,458,544...48,470,260
Ensembl chr X:48,458,537...48,470,260

G

solute carrier family 38 member 6

increases expression

Zidovudine results in increased expression of SLC38A6 mRNA

NCBI chr14:60,981,245...61,083,733
Ensembl chr14:60,981,114...61,114,316

G

solute carrier family 39 member 10

decreases expression

Zidovudine results in decreased expression of SLC39A10 mRNA

NCBI chr 2:195,613,029...195,737,700
Ensembl chr 2:195,575,977...195,737,702

G

solute carrier family 39 member 14

decreases expression

Zidovudine results in decreased expression of SLC39A14 mRNA

NCBI chr 8:22,367,278...22,434,129
Ensembl chr 8:22,367,278...22,434,129

G

solute carrier family 39 member 9

increases expression

Zidovudine results in increased expression of SLC39A9 mRNA

NCBI chr14:69,398,384...69,462,390
Ensembl chr14:69,398,015...69,462,390

G

solute carrier family 3 member 2

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC3A2 mRNA
Zidovudine results in increased expression of SLC3A2 mRNA

PMID:15784690 PMID:24292225

NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,004...62,888,880

G

solute carrier family 40 member 1

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of SLC40A1 mRNA
Zidovudine results in increased expression of SLC40A1 mRNA

PMID:18313992 PMID:24292225

NCBI chr 2:189,560,590...189,580,786
Ensembl chr 2:189,560,590...189,583,758

G

solute carrier family 4 member 2

increases expression

Zidovudine results in increased expression of SLC4A2 mRNA

NCBI chr 7:151,058,200...151,076,527
Ensembl chr 7:151,057,210...151,076,526

G

solute carrier family 5 member 3

decreases expression

Zidovudine results in decreased expression of SLC5A3 mRNA

NCBI chr21:34,073,578...34,106,260
Ensembl chr21:34,073,578...34,106,260

G

solute carrier family 6 member 11

increases expression

Zidovudine results in increased expression of SLC6A11 mRNA

NCBI chr 3:10,816,228...10,940,714
Ensembl chr 3:10,816,201...10,940,714

G

solute carrier family 6 member 12

increases expression

Zidovudine results in increased expression of SLC6A12 mRNA

NCBI chr12:183,848...214,157
Ensembl chr12:190,077...214,570

G

solute carrier family 6 member 2

increases expression

Zidovudine results in increased expression of SLC6A2 mRNA

NCBI chr16:55,655,988...55,706,192
Ensembl chr16:55,655,988...55,707,645

G

solute carrier family 6 member 8

decreases expression

Zidovudine results in decreased expression of SLC6A8 mRNA

NCBI chr X:153,687,926...153,696,593
Ensembl chr X:153,687,926...153,696,588

G

solute carrier family 7 member 10

decreases expression
increases expression

Zidovudine results in decreased expression of SLC7A10 mRNA
Zidovudine results in increased expression of SLC7A10 mRNA

NCBI chr19:33,208,664...33,225,850
Ensembl chr19:33,208,664...33,225,850

G

solute carrier family 7 member 2

decreases expression

Zidovudine results in decreased expression of SLC7A2 mRNA

NCBI chr 8:17,494,069...17,570,566
Ensembl chr 8:17,497,088...17,570,573

G

solute carrier family 7 member 5

increases expression

Zidovudine results in increased expression of SLC7A5 mRNA

NCBI chr16:87,830,023...87,869,507
Ensembl chr16:87,830,023...87,869,507

G

solute carrier family 7 member 7

multiple interactions
increases expression

[Zidovudine co-treated with IFNA1 protein] results in increased expression of SLC7A7 mRNA
Zidovudine results in increased expression of SLC7A7 mRNA

PMID:20370541 PMID:24292225

NCBI chr14:22,773,222...22,819,791
Ensembl chr14:22,773,222...22,829,820

G

solute carrier family 7 member 8

increases expression

Zidovudine results in increased expression of SLC7A8 mRNA

NCBI chr14:23,125,295...23,183,660
Ensembl chr14:23,125,295...23,183,674

G

solute carrier family 7 member 9

increases expression

Zidovudine results in increased expression of SLC7A9 mRNA

NCBI chr19:32,830,511...32,869,767
Ensembl chr19:32,830,509...32,869,767

G

solute carrier family 9 member A1

increases expression

Zidovudine results in increased expression of SLC9A1 mRNA

NCBI chr 1:27,098,809...27,155,125
Ensembl chr 1:27,098,809...27,166,981

G

solute carrier organic anion transporter family member 2A1

decreases expression

Zidovudine results in decreased expression of SLCO2A1 mRNA

NCBI chr 3:133,932,701...134,029,925
Ensembl chr 3:133,932,701...134,052,184

G

solute carrier organic anion transporter family member 2B1

decreases expression
increases expression

Zidovudine results in decreased expression of SLCO2B1 mRNA
Zidovudine results in increased expression of SLCO2B1 mRNA

NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549

G

solute carrier organic anion transporter family member 4A1

decreases expression

Zidovudine results in decreased expression of SLCO4A1 mRNA

NCBI chr20:62,642,503...62,690,740
Ensembl chr20:62,642,503...62,685,785

G

superoxide dismutase 2

decreases response to substance
multiple interactions

SOD2 protein results in decreased susceptibility to Zidovudine
[SOD2 co-treated with CYP3A4] affects the susceptibility to Zidovudine

PMID:19398959 PMID:19501153

NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529

G

serine peptidase inhibitor Kazal type 5

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of SPINK5 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of SPINK5 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of SPINK5 mRNA

NCBI chr 5:148,063,980...148,137,382
Ensembl chr 5:148,025,683...148,137,382

G

sequestosome 1

increases expression

Zidovudine results in increased expression of SQSTM1 protein

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

steroidogenic acute regulatory protein

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of STAR mRNA

NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992

G

signal transducer and activator of transcription 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT1 mRNA

NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960

G

signal transducer and activator of transcription 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of STAT2 mRNA

NCBI chr12:56,341,597...56,360,107
Ensembl chr12:56,341,597...56,360,203

G

stanniocalcin 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of STC2 mRNA

NCBI chr 5:173,314,723...173,328,414
Ensembl chr 5:173,314,723...173,328,447

G

SUB1 regulator of transcription

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of SUB1 mRNA

NCBI chr 5:32,585,557...32,604,079
Ensembl chr 5:32,531,633...32,604,079

G

transcription elongation factor A1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of TCEA1 mRNA

NCBI chr 8:53,966,556...54,022,448
Ensembl chr 8:53,966,552...54,022,448

G

transcobalamin 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TCN1 mRNA

NCBI chr11:59,852,808...59,866,487
Ensembl chr11:59,852,800...59,866,489

G

transcobalamin 2

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TCN2 mRNA

NCBI chr22:30,607,174...30,627,271
Ensembl chr22:30,607,003...30,627,271

G

telomerase reverse transcriptase

decreases activity

Zidovudine results in decreased activity of TERT protein

PMID:16601281 PMID:18097608

NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068

G

transcription factor A, mitochondrial

increases expression

Zidovudine results in increased expression of TFAM mRNA

NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220

G

transcription factor AP-2 alpha

decreases expression

Zidovudine results in decreased expression of TFAP2A mRNA

NCBI chr 6:10,396,677...10,419,659
Ensembl chr 6:10,393,186...10,419,659

G

transcription factor EB

decreases expression

Zidovudine results in decreased expression of TFEB protein

NCBI chr 6:41,683,978...41,736,223
Ensembl chr 6:41,683,978...41,736,259

G

translocase of inner mitochondrial membrane 17B

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of TIMM17B mRNA

NCBI chr X:48,893,447...48,898,143
Ensembl chr X:48,893,447...48,898,143

G

translocase of inner mitochondrial membrane 23

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of TIMM23 mRNA

NCBI chr10:45,972,489...46,003,742
Ensembl chr10:45,972,489...46,003,742

G

TIMP metallopeptidase inhibitor 2

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TIMP2 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of TIMP2 mRNA

NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387

G

thymidine kinase 1

decreases response to substance
increases expression
decreases expression
increases mutagenesis
increases response to substance
increases metabolic processing
increases activity
increases methylation
decreases activity
affects transport
multiple interactions

TK1 gene modified form results in decreased susceptibility to Zidovudine
Zidovudine results in increased expression of TK1 mRNA; Zidovudine results in increased expression of TK1 protein
Zidovudine results in decreased expression of TK1 mRNA; Zidovudine results in decreased expression of TK1 protein
Zidovudine results in increased mutagenesis of TK1 gene
TK1 protein results in increased susceptibility to Zidovudine
TK1 protein results in increased metabolism of Zidovudine
Zidovudine results in increased activity of TK1 protein
Zidovudine results in increased methylation of TK1 exon
Zidovudine results in decreased activity of TK1 protein
TK1 protein affects the transport of Zidovudine
Ethanol inhibits the reaction [Zidovudine results in increased activity of TK1 protein]; Zidovudine inhibits the reaction [Ethanol results in decreased activity of TK1 protein]

PMID:8915012 PMID:8941356 PMID:11923581 PMID:15013700 PMID:15708581 More...

NCBI chr17:78,174,079...78,187,204
Ensembl chr17:78,174,091...78,187,233

G

thymidine kinase 2

multiple interactions
increases expression

[Zidovudine co-treated with Lamivudine] results in increased expression of TK2 mRNA
Zidovudine results in increased expression of TK2 mRNA

PMID:18313992 PMID:24292225

NCBI chr16:66,508,003...66,550,291
Ensembl chr16:66,508,003...66,552,544

G

toll like receptor 7

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TLR7 mRNA

NCBI chr X:12,867,072...12,890,361
Ensembl chr X:12,867,072...12,890,361

G

transmembrane protein 97

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TMEM97 mRNA

NCBI chr17:28,319,200...28,328,685
Ensembl chr17:28,319,200...28,328,685

G

tenascin C

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TNC mRNA

NCBI chr 9:115,019,575...115,118,157
Ensembl chr 9:115,019,575...115,118,207

G

tumor necrosis factor

decreases expression
increases expression
multiple interactions

Zidovudine analog results in decreased expression of TNF protein
Zidovudine results in increased expression of TNF protein
[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein; silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein]

PMID:12729831 PMID:17668557 PMID:28619387

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF superfamily member 10

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TNFSF10 mRNA

NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475

G

TNF superfamily member 13b

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TNFSF13B mRNA

NCBI chr13:108,269,629...108,308,484
Ensembl chr13:108,251,240...108,308,484

G

troponin I2, fast skeletal type

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TNNI2 mRNA

NCBI chr11:1,838,981...1,841,678
Ensembl chr11:1,838,981...1,841,680

G

troponin I3, cardiac type

affects localization

Zidovudine affects the localization of TNNI3 protein

NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773

G

tumor protein p53

increases expression

Zidovudine results in increased expression of TP53 protein

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546

G

tRNA aspartic acid methyltransferase 1

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRDMT1 mRNA

NCBI chr10:17,137,336...17,201,672
Ensembl chr10:17,137,336...17,202,054

G

tribbles pseudokinase 3

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of TRIB3 mRNA

NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559

G

tripartite motif containing 22

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TRIM22 mRNA

NCBI chr11:5,689,790...5,710,863
Ensembl chr11:5,689,610...5,737,089

G

tripartite motif containing 42

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of TRIM42 mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TRIM42 mRNA; [Zidovudine co-treated with Lamivudine] results in increased expression of TRIM42 mRNA

NCBI chr 3:140,678,064...140,701,150
Ensembl chr 3:140,678,064...140,701,150

G

triple QxxK/R motif containing

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRIQK mRNA

NCBI chr 8:92,883,534...93,017,665
Ensembl chr 8:92,883,532...93,017,673

G

tRNA methyltransferase 44 homolog

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TRMT44 mRNA

NCBI chr 4:8,440,777...8,516,950
Ensembl chr 4:8,436,140...8,493,531

G

tetratricopeptide repeat domain 21A

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TTC21A mRNA

NCBI chr 3:39,107,680...39,138,900
Ensembl chr 3:39,107,680...39,138,903

G

twinkle mtDNA helicase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of TWNK mRNA

NCBI chr10:100,987,543...100,994,403
Ensembl chr10:100,987,367...100,994,403

G

taxilin gamma Y-linked (pseudogene)

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of TXLNGY mRNA

NCBI chr  Y:19,567,358...19,607,170
Ensembl chr  Y:19,567,382...19,604,120
Ensembl chr  Y:19,567,382...19,604,120

G

thymidine phosphorylase

multiple interactions
increases expression
increases activity

[5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] results in decreased susceptibility to [Zidovudine co-treated with doxifluridine]; [Zidovudine results in increased activity of TYMP protein] which results in increased susceptibility to doxifluridine
Zidovudine results in increased expression of TYMP mRNA; Zidovudine results in increased expression of TYMP protein

NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032

G

thymidylate synthetase

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of TYMS mRNA

NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578

G

tyrosinase related protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of TYRP1 mRNA

NCBI chr 9:12,693,385...12,710,285
Ensembl chr 9:12,685,439...12,710,285

G

uncoupling protein 1

increases expression
decreases expression

Zidovudine results in increased expression of UCP1 mRNA
Zidovudine results in decreased expression of UCP1 mRNA

PMID:14518702 PMID:17926646

NCBI chr 4:140,559,431...140,568,961
Ensembl chr 4:140,559,431...140,568,961

G

UDP glucuronosyltransferase family 2 member B17

increases glucuronidation

UGT2B1 protein results in increased glucuronidation of Zidovudine

NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413

G

UDP glucuronosyltransferase family 2 member B7

increases glucuronidation
multiple interactions
decreases expression
increases expression

UGT2B7 protein results in increased glucuronidation of Zidovudine
10-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; 4'-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; 7-hydroxywarfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; [10-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; [4'-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; [7-hydroxywarfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; [Warfarin binds to and results in decreased activity of UGT2B7 protein] which results in decreased glucuronidation of Zidovudine; shikonin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]; Warfarin inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Zidovudine]
Zidovudine results in decreased expression of UGT2B7 mRNA; Zidovudine results in decreased expression of UGT2B7 protein
Zidovudine results in increased expression of UGT2B7 mRNA; Zidovudine results in increased expression of UGT2B7 protein

PMID:10772627 PMID:17898154 PMID:24292225 PMID:25393417 PMID:31128210

NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987

G

unc-51 like autophagy activating kinase 1

decreases phosphorylation

Zidovudine results in decreased phosphorylation of ULK1 protein

NCBI chr12:131,894,622...131,923,150
Ensembl chr12:131,894,622...131,923,150

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of UQCRB mRNA

NCBI chr 8:96,222,947...96,235,545
Ensembl chr 8:96,222,947...96,235,546

G

ubiquinol-cytochrome c reductase core protein 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of UQCRC1 mRNA

PMID:17526437 PMID:18313992

NCBI chr 3:48,599,002...48,609,646
Ensembl chr 3:48,599,002...48,610,976

G

ubiquinol-cytochrome c reductase core protein 2

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of UQCRC2 mRNA

NCBI chr16:21,953,361...21,983,660
Ensembl chr16:21,953,288...21,983,660

G

ubiquitin specific peptidase 18

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of USP18 mRNA

NCBI chr22:18,150,170...18,177,397
Ensembl chr22:18,149,843...18,177,397

G

voltage dependent anion channel 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of VDAC1 mRNA

NCBI chr 5:133,971,871...134,114,540
Ensembl chr 5:133,971,871...134,004,975

G

vitamin D receptor

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of VDR mRNA

NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048

G

vacuolar protein sorting 4 homolog B

multiple interactions

[Zidovudine co-treated with Lamivudine] results in decreased expression of VPS4B mRNA

NCBI chr18:63,389,190...63,422,476
Ensembl chr18:63,389,190...63,422,483

G

tryptophanyl-tRNA synthetase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of WARS1 mRNA

NCBI chr14:100,333,790...100,376,327
Ensembl chr14:100,333,790...100,376,805

G

WD repeat domain 62

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in decreased expression of WDR62 mRNA

NCBI chr19:36,054,897...36,111,145
Ensembl chr19:36,054,649...36,105,108

G

Wnt family member 10A

multiple interactions

[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of WNT10A mRNA; [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of WNT10A mRNA

NCBI chr 2:218,874,116...218,893,928
Ensembl chr 2:218,880,852...218,899,581

G

XPA, DNA damage recognition and repair factor

increases expression

Zidovudine results in increased expression of XPA mRNA; Zidovudine results in increased expression of XPA protein

PMID:21192964 PMID:23675285

NCBI chr 9:97,654,398...97,697,340
Ensembl chr 9:97,674,909...97,697,340

G

XPC complex subunit, DNA damage recognition and repair factor

decreases response to substance
increases expression

XPC protein results in decreased susceptibility to Zidovudine
Zidovudine results in increased expression of XPC mRNA; Zidovudine results in increased expression of XPC protein

PMID:21192964 PMID:23675285

NCBI chr 3:14,145,147...14,178,601
Ensembl chr 3:14,145,147...14,178,621

G

tyrosyl-tRNA synthetase 1

multiple interactions

[Zidovudine co-treated with Lamivudine] results in increased expression of YARS1 mRNA

NCBI chr 1:32,775,239...32,817,358
Ensembl chr 1:32,775,237...32,818,031

G

zinc finger protein 629

multiple interactions

[Zidovudine co-treated with IFNA1 protein] results in increased expression of ZNF629 mRNA

NCBI chr16:30,778,456...30,787,205
Ensembl chr16:30,778,456...30,787,205

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26040
role	25956
biological role	25935
biochemical role	25168
antimetabolite	10578
zidovudine	535
Path 2
Term	Annotations
CHEBI ontology	26040
subatomic particle	26015
composite particle	26015
hadron	26015
baryon	26015
nucleon	26015
atomic nucleus	26015
atom	26015
main group element atom	25840
p-block element atom	25840
carbon group element atom	25437
carbon atom	25395
organic molecular entity	25395
heteroorganic entity	24770
organochalcogen compound	24383
organooxygen compound	24060
carbohydrates and carbohydrate derivatives	16777
carbohydrate	16777
carbohydrate derivative	15654
glycosyl compound	13719
N-glycosyl compound	6127
nucleoside	5971
deoxyribonucleoside	3000
2',3'-dideoxyribonucleoside	578
pyrimidine 2',3'-dideoxyribonucleoside	573
zidovudine	535

paths to the root