CDC25A (cell division cycle 25A) - Rat Genome Database

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Gene: CDC25A (cell division cycle 25A) Homo sapiens
Analyze
Symbol: CDC25A
Name: cell division cycle 25A
RGD ID: 731492
HGNC Page HGNC
Description: Enables chaperone binding activity and protein kinase binding activity. Involved in cellular response to UV. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Implicated in cervical cancer; prostate cancer; and urinary bladder cancer. Biomarker of autosomal recessive polycystic kidney disease; breast carcinoma; and vulva squamous cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDC25 homolog A; CDC25 isoform A1-CAG; CDC25A2; CDC25A2-CAG isoform; dual specificity phosphatase CDC25A; M-phase inducer phosphatase 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl348,157,146 - 48,188,417 (-)EnsemblGRCh38hg38GRCh38
GRCh38348,157,146 - 48,188,417 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37348,198,636 - 48,229,907 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,173,672 - 48,204,805 (-)NCBINCBI36hg18NCBI36
Build 34348,173,671 - 48,204,805NCBI
Celera348,147,668 - 48,178,797 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef348,253,008 - 48,284,141 (-)NCBIHuRef
CHM1_1348,150,488 - 48,181,619 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-taxifolin  (EXP)
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(20R)-protopanaxadiol  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (EXP)
adenine  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
amiodarone  (EXP)
aristolochic acid  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
atrazine  (EXP)
azathioprine  (EXP)
bazedoxifene  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bosutinib  (ISO)
Butylparaben  (EXP)
calcitriol  (EXP)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
cyclosporin A  (EXP)
daunorubicin  (EXP)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichlorvos  (ISO)
diethyl maleate  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
Enterolactone  (EXP)
entinostat  (EXP)
ethanol  (EXP)
etoposide  (EXP)
fenhexamid  (EXP)
fenofibrate  (ISO)
folic acid  (EXP)
furan  (ISO)
gentamycin  (ISO)
geraniol  (EXP)
glyphosate  (EXP)
GW 3965  (EXP)
harmine  (EXP)
hydrogen peroxide  (EXP)
hydroxytyrosol  (EXP)
hydroxyurea  (ISO)
Lasiocarpine  (EXP)
leptomycin B  (EXP)
Licochalcone B  (EXP)
lipopolysaccharide  (ISO)
metformin  (EXP)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
methylparaben  (EXP)
methylseleninic acid  (EXP)
monocrotaline  (EXP)
Muraglitazar  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
n-propyl gallate  (ISO)
nelfinavir  (EXP)
nickel atom  (EXP)
nickel dichloride  (ISO)
nicotine  (EXP)
ochratoxin A  (EXP)
paclitaxel  (EXP,ISO)
palbociclib  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
piroxicam  (EXP)
potassium chromate  (EXP)
propylparaben  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rotenone  (EXP,ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (EXP)
sunitinib  (EXP)
tamibarotene  (EXP)
tamoxifen  (EXP)
teriflunomide  (EXP)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioridazine  (EXP)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
Tylophorine  (EXP)
valproic acid  (EXP,ISO)
vemurafenib  (EXP)
wortmannin  (ISO)
zidovudine  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1828290   PMID:1836978   PMID:7644510   PMID:7667636   PMID:7744247   PMID:8276402   PMID:8617791   PMID:8668211   PMID:9230211   PMID:9278511   PMID:9466490   PMID:9604936  
PMID:9707427   PMID:9779991   PMID:9858615   PMID:9891079   PMID:9989807   PMID:10373478   PMID:10373531   PMID:10454565   PMID:10454584   PMID:10724175   PMID:10740819   PMID:10766737  
PMID:10827953   PMID:10926775   PMID:11106571   PMID:11139144   PMID:11298456   PMID:11416155   PMID:11584018   PMID:11585757   PMID:11752153   PMID:11805096   PMID:11912208   PMID:12110582  
PMID:12234927   PMID:12388094   PMID:12399544   PMID:12411508   PMID:12477932   PMID:12676583   PMID:12676925   PMID:12738732   PMID:12759351   PMID:12791985   PMID:12801928   PMID:12963847  
PMID:14517313   PMID:14559997   PMID:14603323   PMID:14657354   PMID:14673957   PMID:14681206   PMID:14727060   PMID:14752276   PMID:14767575   PMID:15161933   PMID:15311285   PMID:15489334  
PMID:15536641   PMID:15572030   PMID:15798217   PMID:16189514   PMID:16191191   PMID:16338364   PMID:16598773   PMID:16644029   PMID:16720623   PMID:16912045   PMID:17001315   PMID:17018577  
PMID:17172867   PMID:17292828   PMID:17545210   PMID:17671423   PMID:17676996   PMID:17912454   PMID:18029348   PMID:18073536   PMID:18160429   PMID:18167338   PMID:18204780   PMID:18316586  
PMID:18480045   PMID:18566993   PMID:18676680   PMID:18794133   PMID:18927589   PMID:18980975   PMID:19013180   PMID:19060337   PMID:19062161   PMID:19170196   PMID:19289404   PMID:19305144  
PMID:19367581   PMID:19417033   PMID:19477924   PMID:19615732   PMID:19621387   PMID:19625176   PMID:19692168   PMID:19738433   PMID:19738611   PMID:19833767   PMID:19966869   PMID:20090422  
PMID:20217459   PMID:20228808   PMID:20348946   PMID:20368335   PMID:20379614   PMID:20453000   PMID:20462953   PMID:20606298   PMID:20614206   PMID:20639859   PMID:20956543   PMID:21344162  
PMID:21376736   PMID:21575861   PMID:21670150   PMID:21832049   PMID:21873635   PMID:21900206   PMID:21988832   PMID:22017875   PMID:22065597   PMID:22160829   PMID:22417828   PMID:22435685  
PMID:22467868   PMID:22658674   PMID:22705122   PMID:22843495   PMID:22899714   PMID:23240008   PMID:23314229   PMID:23397142   PMID:23467652   PMID:23675485   PMID:23708659   PMID:23730206  
PMID:24211536   PMID:24269534   PMID:24429874   PMID:24939300   PMID:24993091   PMID:25266660   PMID:25326518   PMID:25332235   PMID:25378484   PMID:25397735   PMID:25515538   PMID:25609649  
PMID:25900982   PMID:25909324   PMID:25936524   PMID:25990966   PMID:26091241   PMID:26474275   PMID:26515730   PMID:26647881   PMID:26967250   PMID:26972000   PMID:27053344   PMID:27384875  
PMID:27432908   PMID:27462461   PMID:27485204   PMID:27580187   PMID:27644634   PMID:27880917   PMID:28094252   PMID:28192398   PMID:28319085   PMID:28330616   PMID:28333141   PMID:28333146  
PMID:28514442   PMID:28675297   PMID:28951130   PMID:29150431   PMID:29416040   PMID:29672635   PMID:29863914   PMID:30021884   PMID:30021902   PMID:30443958   PMID:30635443   PMID:30718768  
PMID:30858545   PMID:30902389   PMID:30945288   PMID:31505105   PMID:31586073   PMID:31615875   PMID:31799646   PMID:31922225   PMID:32024878   PMID:32296183   PMID:32415280   PMID:32694731  
PMID:32860838   PMID:32869878   PMID:33282948   PMID:33306668   PMID:33742524   PMID:33854235   PMID:33961781   PMID:34071237   PMID:34314996  


Genomics

Comparative Map Data
CDC25A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl348,157,146 - 48,188,417 (-)EnsemblGRCh38hg38GRCh38
GRCh38348,157,146 - 48,188,417 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37348,198,636 - 48,229,907 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,173,672 - 48,204,805 (-)NCBINCBI36hg18NCBI36
Build 34348,173,671 - 48,204,805NCBI
Celera348,147,668 - 48,178,797 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef348,253,008 - 48,284,141 (-)NCBIHuRef
CHM1_1348,150,488 - 48,181,619 (-)NCBICHM1_1
Cdc25a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,704,545 - 109,722,963 (+)NCBIGRCm39mm39
GRCm39 Ensembl9109,704,647 - 109,722,963 (+)Ensembl
GRCm389109,875,518 - 109,893,895 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,875,579 - 109,893,895 (+)EnsemblGRCm38mm10GRCm38
MGSCv379109,778,083 - 109,796,394 (+)NCBIGRCm37mm9NCBIm37
MGSCv369109,733,366 - 109,751,296 (+)NCBImm8
Celera9109,601,935 - 109,621,511 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.81NCBI
Cdc25a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28109,864,356 - 109,882,734 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl8109,864,478 - 109,882,701 (+)Ensembl
Rnor_6.08117,953,223 - 117,971,552 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,953,444 - 117,971,519 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,305,748 - 117,324,074 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,237,704 - 114,255,971 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18114,257,158 - 114,275,426 (+)NCBI
Celera8109,154,287 - 109,172,351 (+)NCBICelera
Cytogenetic Map8q32NCBI
Cdc25a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542024,344,388 - 24,362,596 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542024,345,002 - 24,361,802 (+)NCBIChiLan1.0ChiLan1.0
CDC25A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1349,154,307 - 49,186,115 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,154,307 - 49,186,115 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0348,068,601 - 48,099,806 (-)NCBIMhudiblu_PPA_v0panPan3
CDC25A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,823,683 - 40,849,113 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,823,459 - 40,847,608 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,741,248 - 40,764,940 (+)NCBI
ROS_Cfam_1.02041,309,415 - 41,334,896 (+)NCBI
UMICH_Zoey_3.12040,549,928 - 40,573,619 (+)NCBI
UNSW_CanFamBas_1.02040,951,503 - 40,974,658 (+)NCBI
UU_Cfam_GSD_1.02041,231,962 - 41,255,400 (+)NCBI
Cdc25a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118202,108,272 - 202,130,970 (-)NCBI
SpeTri2.0NW_0049365961,657,411 - 1,680,109 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC25A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21334,164,323 - 34,190,078 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDC25A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,534,114 - 9,564,927 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl229,534,053 - 9,564,741 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041157,537,318 - 157,569,097 (+)NCBIVero_WHO_p1.0
Cdc25a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473073,443,895 - 73,463,979 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH80886  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37348,212,039 - 48,212,267UniSTSGRCh37
GRCh37768,930,454 - 68,930,676UniSTSGRCh37
Build 36348,187,043 - 48,187,271RGDNCBI36
Celera348,161,041 - 48,161,269RGD
Celera762,311,576 - 62,311,798UniSTS
Cytogenetic Map3p21UniSTS
HuRef765,110,227 - 65,110,449UniSTS
HuRef348,266,385 - 48,266,613UniSTS
CRA_TCAGchr7v2768,269,591 - 68,269,813UniSTS
GDB:252110  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37348,229,566 - 48,229,763UniSTSGRCh37
Build 36348,204,570 - 48,204,767RGDNCBI36
Celera348,178,562 - 48,178,759RGD
Cytogenetic Map3p21UniSTS
HuRef348,283,906 - 48,284,103UniSTS
D3S4246  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37348,199,905 - 48,200,035UniSTSGRCh37
Build 36348,174,909 - 48,175,039RGDNCBI36
Celera348,148,905 - 48,149,035RGD
Cytogenetic Map3p21UniSTS
HuRef348,254,245 - 48,254,375UniSTS
CDC25A_518.2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37348,198,623 - 48,199,376UniSTSGRCh37
Build 36348,173,627 - 48,174,380RGDNCBI36
Celera348,147,623 - 48,148,376RGD
HuRef348,252,963 - 48,253,716UniSTS
RH11459  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37348,200,047 - 48,200,160UniSTSGRCh37
Build 36348,175,051 - 48,175,164RGDNCBI36
Celera348,149,047 - 48,149,160RGD
Cytogenetic Map3p21UniSTS
HuRef348,254,387 - 48,254,500UniSTS
GeneMap99-GB4 RH Map3154.63UniSTS
D3S4167  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37348,200,047 - 48,200,254UniSTSGRCh37
Build 36348,175,051 - 48,175,258RGDNCBI36
Celera348,149,047 - 48,149,254RGD
Cytogenetic Map3p21UniSTS
HuRef348,254,387 - 48,254,594UniSTS
Stanford-G3 RH Map32077.0UniSTS
GeneMap99-G3 RH Map31975.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR449Ahsa-miR-449aTarbaseexternal_infoReporter GenePOSITIVE
MIR449Ahsa-miR-449aTarbaseexternal_infoWesternblitPOSITIVE
MIRLET7Bhsa-let-7b-5pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCRFunctional MTI (Weak)19966857
MIRLET7Bhsa-let-7b-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI17699775
MIRLET7Bhsa-let-7b-5pMirecordsexternal_info{changed}NA18026111
MIR21hsa-miR-21-5pMirecordsexternal_info{changed}NA19826040
MIR21hsa-miR-21-5pOncomiRDBexternal_infoNANA19826040
MIR21hsa-miR-21-5pMirtarbaseexternal_infoMicroarray//Northern blot//qRT-PCRFunctional MTI (Weak)19826040
MIR21hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23496142
MIR15Ahsa-miR-15a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18949056
MIR449Bhsa-miR-449b-5pMirtarbaseexternal_infoReporter assay;Western blotFunctional MTI19833767
MIR503hsa-miR-503-3pMirecordsexternal_info{changed}NA21220732

Predicted Target Of
Summary Value
Count of predictions:2282
Count of miRNA genes:838
Interacting mature miRNAs:990
Transcripts:ENST00000302506, ENST00000351231, ENST00000437972, ENST00000443342, ENST00000459900
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 158 11 40 33 636 36 262 49 99 58 584 218 8 2
Low 1058 945 1366 323 716 179 1847 448 2127 265 741 1038 146 440 1184 3 2
Below cutoff 1222 2017 318 267 571 249 2246 1692 1500 95 132 353 19 764 1602

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_201567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006713434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006713435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001740392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC104190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF112978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF277722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF527417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI917350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ242714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY137580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ065803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX392016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ083511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU812118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ866789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M81933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000302506   ⟹   ENSP00000303706
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl348,157,146 - 48,188,417 (-)Ensembl
RefSeq Acc Id: ENST00000351231   ⟹   ENSP00000343166
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl348,157,146 - 48,188,356 (-)Ensembl
RefSeq Acc Id: ENST00000437972   ⟹   ENSP00000404285
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl348,182,929 - 48,188,402 (-)Ensembl
RefSeq Acc Id: ENST00000443342   ⟹   ENSP00000416483
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl348,177,366 - 48,187,966 (-)Ensembl
RefSeq Acc Id: ENST00000459900
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl348,164,402 - 48,174,753 (-)Ensembl
RefSeq Acc Id: NM_001789   ⟹   NP_001780
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38348,157,146 - 48,188,417 (-)NCBI
GRCh37348,198,668 - 48,230,153 (-)NCBI
Build 36348,173,672 - 48,204,805 (-)NCBI Archive
HuRef348,253,008 - 48,284,141 (-)ENTREZGENE
CHM1_1348,150,488 - 48,181,619 (-)NCBI
Sequence:
RefSeq Acc Id: NM_201567   ⟹   NP_963861
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38348,157,146 - 48,188,417 (-)NCBI
GRCh37348,198,668 - 48,230,153 (-)NCBI
Build 36348,173,672 - 48,204,805 (-)NCBI Archive
HuRef348,253,008 - 48,284,141 (-)ENTREZGENE
CHM1_1348,150,488 - 48,181,619 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006713434   ⟹   XP_006713497
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38348,157,178 - 48,188,402 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006713435   ⟹   XP_006713498
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38348,157,178 - 48,188,405 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001740392
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38348,157,178 - 48,187,985 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_963861   ⟸   NM_201567
- Peptide Label: isoform b
- UniProtKB: P30304 (UniProtKB/Swiss-Prot),   A0A024R2R6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001780   ⟸   NM_001789
- Peptide Label: isoform a
- UniProtKB: P30304 (UniProtKB/Swiss-Prot),   A0A024R2S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006713498   ⟸   XM_006713435
- Peptide Label: isoform X2
- UniProtKB: D8KXX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006713497   ⟸   XM_006713434
- Peptide Label: isoform X1
- UniProtKB: K7N7S0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000404285   ⟸   ENST00000437972
RefSeq Acc Id: ENSP00000416483   ⟸   ENST00000443342
RefSeq Acc Id: ENSP00000343166   ⟸   ENST00000351231
RefSeq Acc Id: ENSP00000303706   ⟸   ENST00000302506
Protein Domains
Rhodanese

Promoters
RGD ID:6864280
Promoter ID:EPDNEW_H5305
Type:initiation region
Name:CDC25A_1
Description:cell division cycle 25A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38348,188,417 - 48,188,477EPDNEW
RGD ID:6800754
Promoter ID:HG_KWN:44876
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000257512,   OTTHUMT00000257513,   OTTHUMT00000346149,   OTTHUMT00000346150
Position:
Human AssemblyChrPosition (strand)Source
Build 36348,204,311 - 48,205,072 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p21.31(chr3:47867990-48259991)x3 copy number gain See cases [RCV000051467] Chr3:47867990..48259991 [GRCh38]
Chr3:47909480..48301481 [GRCh37]
Chr3:47884484..48276485 [NCBI36]
Chr3:3p21.31
uncertain significance
GRCh38/hg38 3p21.31-21.2(chr3:45879883-50749922)x4 copy number gain See cases [RCV000133650] Chr3:45879883..50749922 [GRCh38]
Chr3:45921375..50787353 [GRCh37]
Chr3:45896379..50762357 [NCBI36]
Chr3:3p21.31-21.2
pathogenic
GRCh37/hg19 3p22.2-21.31(chr3:37028313-49929220)x3 copy number gain See cases [RCV000240519] Chr3:37028313..49929220 [GRCh37]
Chr3:3p22.2-21.31
likely pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p21.31(chr3:47899878-48348163)x3 copy number gain not provided [RCV000742393] Chr3:47899878..48348163 [GRCh37]
Chr3:3p21.31
benign
GRCh37/hg19 3p21.31-21.1(chr3:45153770-53878616) copy number gain not provided [RCV000767704] Chr3:45153770..53878616 [GRCh37]
Chr3:3p21.31-21.1
pathogenic
GRCh37/hg19 3p21.31(chr3:47799614-48359988)x3 copy number gain not provided [RCV000848232] Chr3:47799614..48359988 [GRCh37]
Chr3:3p21.31
uncertain significance
GRCh37/hg19 3p21.31(chr3:47927728-48206720)x3 copy number gain not provided [RCV000846731] Chr3:47927728..48206720 [GRCh37]
Chr3:3p21.31
uncertain significance
NM_001789.3(CDC25A):c.72G>T (p.Gln24His) single nucleotide variant not provided [RCV000950103] Chr3:48187876 [GRCh38]
Chr3:48229366 [GRCh37]
Chr3:3p21.31
benign
GRCh37/hg19 3p21.31(chr3:47970377-48227462)x3 copy number gain not provided [RCV001005431] Chr3:47970377..48227462 [GRCh37]
Chr3:3p21.31
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1725 AgrOrtholog
COSMIC CDC25A COSMIC
Ensembl Genes ENSG00000164045 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000303706 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000343166 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000404285 UniProtKB/TrEMBL
  ENSP00000416483 UniProtKB/TrEMBL
Ensembl Transcript ENST00000302506 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000351231 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000437972 UniProtKB/TrEMBL
  ENST00000443342 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000164045 GTEx
HGNC ID HGNC:1725 ENTREZGENE
Human Proteome Map CDC25A Human Proteome Map
InterPro MPI_Phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:993 UniProtKB/Swiss-Prot
NCBI Gene 993 ENTREZGENE
OMIM 116947 OMIM
Pfam M-inducer_phosp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodanese UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26259 PharmGKB
PRINTS MPIPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RHOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R2R6 ENTREZGENE, UniProtKB/TrEMBL
  A0A024R2S4 ENTREZGENE
  C9JFR5_HUMAN UniProtKB/TrEMBL
  C9JH94_HUMAN UniProtKB/TrEMBL
  D8KXX0 ENTREZGENE, UniProtKB/TrEMBL
  K7N7S0 ENTREZGENE, UniProtKB/TrEMBL
  MPIP1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8IZH5 UniProtKB/Swiss-Prot
  Q96IL3 UniProtKB/Swiss-Prot
  Q9H2F2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-22 CDC25A  cell division cycle 25A    cell division cycle 25 homolog A (S. pombe)  Symbol and/or name change 5135510 APPROVED
2011-08-16 CDC25A  cell division cycle 25 homolog A (S. pombe)  CDC25A  cell division cycle 25 homolog A (S. pombe)  Symbol and/or name change 5135510 APPROVED