LEF1 (lymphoid enhancer binding factor 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: LEF1 (lymphoid enhancer binding factor 1) Homo sapiens
Analyze
Symbol: LEF1
Name: lymphoid enhancer binding factor 1
RGD ID: 735736
HGNC Page HGNC:6551
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; beta-catenin binding activity; and protein domain specific binding activity. Involved in several processes, including neutrophil differentiation; positive regulation of cell differentiation; and regulation of gene expression. Located in beta-catenin-TCF complex and cytoplasm. Part of protein-DNA complex and transcription regulator complex. Implicated in ovarian cancer. Biomarker of prostate cancer; prostate carcinoma in situ; and thyroid gland papillary carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DKFZp586H0919; FLJ46390; LEF-1; lymphoid enhancer-binding factor 1; T cell-specific transcription factor 1-alpha; TCF1-alpha; TCF10; TCF1ALPHA; TCF7L3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384108,047,548 - 108,168,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4108,047,545 - 108,168,956 (-)EnsemblGRCh38hg38GRCh38
GRCh374108,968,704 - 109,090,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364109,188,150 - 109,309,027 (-)NCBINCBI36Build 36hg18NCBI36
Build 344109,326,304 - 109,447,182NCBI
Celera4106,263,513 - 106,384,975 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4104,700,344 - 104,821,596 (-)NCBIHuRef
CHM1_14108,945,152 - 109,066,566 (-)NCBICHM1_1
T2T-CHM13v2.04111,349,885 - 111,471,256 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dibromoethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
1,8-cineole  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
2-nitrotoluene  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-formyltetrahydrofolic acid  (ISO)
8-Br-cAMP  (EXP)
acetaldehyde  (ISO)
acrylamide  (EXP,ISO)
adenosine  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
allethrin  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid A  (EXP)
arotinoid acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
casticin  (EXP)
celastrol  (ISO)
CGP 52608  (EXP)
CHIR 99021  (EXP)
choline  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (EXP)
cortisol  (EXP)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
deguelin  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (EXP)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
emodin  (ISO)
endosulfan  (EXP)
entinostat  (EXP)
etacrynic acid  (EXP)
ethosuximide  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
gentamycin  (ISO)
glucose  (EXP)
glycidol  (ISO)
hydralazine  (EXP)
hydroquinone  (EXP)
isoorientin  (EXP)
L-ascorbic acid  (EXP)
L-ascorbic acid 2-phosphate  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
lithium chloride  (ISO)
loliolide  (EXP)
lovastatin  (EXP)
LY294002  (EXP)
menadione  (ISO)
methapyrilene  (EXP)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl carbamate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
methylparaben  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-Vinyl-2-pyrrolidone  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nitrofen  (ISO)
ouabain  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pyrethrins  (ISO)
quercetin  (EXP)
quercitrin  (EXP)
quinolin-8-ol  (ISO)
rac-lactic acid  (EXP)
resveratrol  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
saquinavir  (ISO)
SB 415286  (ISO)
SB 431542  (EXP)
silicon dioxide  (EXP)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
sulindac  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP)
thymoquinone  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
tungsten  (ISO)
valproic acid  (EXP,ISO)
XAV939  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell differentiation  (IEA,ISO)
anatomical structure regression  (IEA,ISO)
animal organ regeneration  (ISO)
apoptotic process involved in blood vessel morphogenesis  (IEA,ISO)
apoptotic process involved in morphogenesis  (IEA,ISO)
B cell proliferation  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
canonical Wnt signaling pathway  (IBA,IDA,IEA)
cell adhesion  (ISO)
cell chemotaxis  (IDA)
cell development  (IEA,ISO)
cellular response to cytokine stimulus  (IMP)
cellular response to interleukin-4  (IDA)
chorio-allantoic fusion  (IEA,ISO)
dentate gyrus development  (IEA,ISO)
embryonic limb morphogenesis  (IEA,ISO)
epithelial cell apoptotic process  (IEA,ISO)
epithelial to mesenchymal transition  (IEA,ISS)
face morphogenesis  (IEA,ISO)
forebrain neuroblast division  (IEA,ISO)
forebrain radial glial cell differentiation  (IEA,ISO)
formation of radial glial scaffolds  (IEA,ISO)
hippocampus development  (IEA,ISO)
kidney development  (ISO)
mammary gland development  (IEA,ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of apoptotic process in bone marrow cell  (IMP)
negative regulation of DNA-templated transcription  (IDA,IEA,IMP,ISO)
negative regulation of interleukin-13 production  (IDA)
negative regulation of interleukin-4 production  (IDA)
negative regulation of interleukin-5 production  (IDA)
negative regulation of striated muscle tissue development  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,IMP,ISO)
neutrophil differentiation  (IMP)
odontoblast differentiation  (ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
osteoblast differentiation  (IEP)
paraxial mesoderm formation  (IEA,ISO)
positive regulation of cell cycle process  (IDA)
positive regulation of cell differentiation  (NAS)
positive regulation of cell migration  (IMP)
positive regulation of cell proliferation in bone marrow  (IMP)
positive regulation of chondrocyte proliferation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IDA,IEA,IMP,ISO)
positive regulation of epithelial to mesenchymal transition  (IMP)
positive regulation of gamma-delta T cell differentiation  (IEA,ISS)
positive regulation of gene expression  (IDA)
positive regulation of granulocyte differentiation  (IDA,IMP)
positive regulation of odontoblast differentiation  (IEA,ISS)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,IMP,ISO,ISS)
positive regulation of Wnt signaling pathway  (IEA,ISO)
protein localization to chromatin  (IMP)
regulation of cell-cell adhesion  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of neurogenesis  (NAS)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
regulation of Wnt signaling pathway  (IEA,ISO)
response to organic cyclic compound  (ISO)
secondary palate development  (IEA,ISS)
sensory perception of taste  (IEA,ISO)
skin development  (ISO)
somitogenesis  (IEA,ISO)
sprouting angiogenesis  (IEA,ISO)
T cell receptor V(D)J recombination  (IEA,ISO)
T-helper 1 cell differentiation  (IEA,ISS)
tongue development  (IEA,ISO)
trachea gland development  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
vasculature development  (IEA,ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Expression and colocalization of beta-catenin and lymphoid enhancing factor-1 in prostate cancer progression. Bauman TM, etal., Hum Pathol. 2016 May;51:124-33. doi: 10.1016/j.humpath.2015.12.024. Epub 2016 Jan 19.
2. The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy. Chen X, etal., Mol Cell Biol. 2006 Jun;26(12):4462-73.
3. WNT10A/ß-catenin pathway in tumorigenesis of papillary thyroid carcinoma. Dong T, etal., Oncol Rep. 2017 Aug;38(2):1287-1294. doi: 10.3892/or.2017.5777. Epub 2017 Jul 3.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta. Rask K, etal., Br J Cancer. 2003 Oct 6;89(7):1298-304.
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. TCF transcription factors: molecular switches in carcinogenesis. Roose J and Clevers H, Biochim Biophys Acta. 1999 Oct 29;1424(2-3):M23-37.
11. Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease. Xian S, etal., Mol Med Rep. 2021 Jan;23(1):10. doi: 10.3892/mmr.2020.11648. Epub 2020 Nov 12.
12. Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation. Zhong N, etal., Bone. 2006 Jul;39(1):5-16. Epub 2006 Feb 3.
Additional References at PubMed
PMID:1783375   PMID:1827423   PMID:1989880   PMID:2010090   PMID:7537238   PMID:7657162   PMID:7958926   PMID:8125298   PMID:8631802   PMID:8757136   PMID:9119227   PMID:9119228  
PMID:9419974   PMID:9488439   PMID:9671491   PMID:9751710   PMID:9843967   PMID:10644691   PMID:10756202   PMID:10825188   PMID:10890911   PMID:10958684   PMID:11266540   PMID:11326276  
PMID:11440173   PMID:11604490   PMID:11696550   PMID:11731474   PMID:11751639   PMID:11835406   PMID:12032083   PMID:12048204   PMID:12052822   PMID:12077367   PMID:12095232   PMID:12161443  
PMID:12183361   PMID:12192039   PMID:12235165   PMID:12408825   PMID:12446687   PMID:12477932   PMID:12551949   PMID:12556497   PMID:12589056   PMID:12707037   PMID:12748295   PMID:12901858  
PMID:14661054   PMID:14759258   PMID:14990565   PMID:15000148   PMID:15143193   PMID:15194563   PMID:15245424   PMID:15489334   PMID:15525529   PMID:15684397   PMID:15728254   PMID:15750622  
PMID:15756419   PMID:15768032   PMID:16014379   PMID:16120831   PMID:16142310   PMID:16204248   PMID:16228014   PMID:16344550   PMID:16415175   PMID:16424171   PMID:16474850   PMID:16510874  
PMID:16510875   PMID:16565724   PMID:16714285   PMID:16809766   PMID:17063141   PMID:17132729   PMID:17240357   PMID:17360796   PMID:17466981   PMID:17510365   PMID:17517646   PMID:17585052  
PMID:17785436   PMID:17785445   PMID:17947518   PMID:17980157   PMID:18029348   PMID:18077326   PMID:18296023   PMID:18316418   PMID:18445004   PMID:18579517   PMID:18615589   PMID:18794125  
PMID:18936100   PMID:19060910   PMID:19079342   PMID:19131506   PMID:19223551   PMID:19244345   PMID:19274049   PMID:19304756   PMID:19351848   PMID:19402906   PMID:19453261   PMID:19460168  
PMID:19576624   PMID:19590514   PMID:19620402   PMID:19653274   PMID:19784072   PMID:20018240   PMID:20019092   PMID:20098615   PMID:20123964   PMID:20124220   PMID:20128911   PMID:20194509  
PMID:20211142   PMID:20219685   PMID:20332099   PMID:20360943   PMID:20363964   PMID:20595513   PMID:20634891   PMID:20676368   PMID:21190562   PMID:21270130   PMID:21282610   PMID:21285352  
PMID:21383983   PMID:21444716   PMID:21471213   PMID:21527502   PMID:21544627   PMID:21599871   PMID:21685909   PMID:21743491   PMID:21744004   PMID:21781440   PMID:21795403   PMID:21873635  
PMID:21980470   PMID:21988832   PMID:21998751   PMID:22020335   PMID:22111711   PMID:22261717   PMID:22291604   PMID:22359570   PMID:22436613   PMID:22507326   PMID:22639890   PMID:22686279  
PMID:22766851   PMID:22769578   PMID:22792274   PMID:22815426   PMID:22837378   PMID:22905168   PMID:23001182   PMID:23068607   PMID:23224985   PMID:23325550   PMID:23375451   PMID:23377854  
PMID:23449499   PMID:23572277   PMID:23713453   PMID:23770605   PMID:23913826   PMID:24021930   PMID:24098538   PMID:24378360   PMID:24394665   PMID:24412244   PMID:24419084   PMID:24577083  
PMID:24658583   PMID:24748645   PMID:24785257   PMID:24847765   PMID:24858819   PMID:24897388   PMID:25343173   PMID:25394300   PMID:25497834   PMID:25587085   PMID:25596247   PMID:25639559  
PMID:25646419   PMID:25808920   PMID:25942645   PMID:25955539   PMID:26186194   PMID:26339357   PMID:26580798   PMID:26588989   PMID:26950276   PMID:26972000   PMID:27195665   PMID:27433921  
PMID:27609421   PMID:27637333   PMID:27684187   PMID:27811057   PMID:27908728   PMID:27965462   PMID:28027119   PMID:28038713   PMID:28122350   PMID:28395058   PMID:28473536   PMID:28514442  
PMID:28639890   PMID:28664938   PMID:28943339   PMID:28972308   PMID:29369390   PMID:29374064   PMID:29736797   PMID:29953980   PMID:29974668   PMID:29991769   PMID:30021253   PMID:30026867  
PMID:30193961   PMID:30270548   PMID:30446587   PMID:30468298   PMID:30630973   PMID:30696957   PMID:30706227   PMID:30886049   PMID:30918012   PMID:30920079   PMID:30968150   PMID:31253399  
PMID:31289135   PMID:31296250   PMID:31513434   PMID:31623618   PMID:31626715   PMID:31753039   PMID:31758089   PMID:31848806   PMID:31953940   PMID:32022899   PMID:32068261   PMID:32329830  
PMID:32401815   PMID:32403323   PMID:32534708   PMID:32555380   PMID:32586085   PMID:32633375   PMID:32645172   PMID:32703426   PMID:32732957   PMID:32760207   PMID:32824603   PMID:32856045  
PMID:32911434   PMID:32933177   PMID:32977233   PMID:32980885   PMID:33165091   PMID:33245988   PMID:33314668   PMID:33398088   PMID:33431799   PMID:33523480   PMID:33608451   PMID:33644029  
PMID:33677883   PMID:33844466   PMID:33887729   PMID:33961781   PMID:34021424   PMID:34048981   PMID:34096776   PMID:34269120   PMID:34337014   PMID:34397171   PMID:34563944   PMID:34639214  
PMID:35066013   PMID:35139734   PMID:35421421   PMID:35583550   PMID:35594394   PMID:35628310   PMID:35871391   PMID:35950640   PMID:35960138   PMID:36045537   PMID:36153326   PMID:36484736  
PMID:36647795   PMID:36877308   PMID:36997001   PMID:37106379   PMID:37462205   PMID:37523793   PMID:37530485   PMID:37553362   PMID:37961030   PMID:38113273   PMID:38169425  


Genomics

Comparative Map Data
LEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384108,047,548 - 108,168,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4108,047,545 - 108,168,956 (-)EnsemblGRCh38hg38GRCh38
GRCh374108,968,704 - 109,090,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364109,188,150 - 109,309,027 (-)NCBINCBI36Build 36hg18NCBI36
Build 344109,326,304 - 109,447,182NCBI
Celera4106,263,513 - 106,384,975 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4104,700,344 - 104,821,596 (-)NCBIHuRef
CHM1_14108,945,152 - 109,066,566 (-)NCBICHM1_1
T2T-CHM13v2.04111,349,885 - 111,471,256 (-)NCBIT2T-CHM13v2.0
Lef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393130,903,972 - 131,018,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3130,904,120 - 131,018,005 (+)EnsemblGRCm39 Ensembl
GRCm383131,110,297 - 131,224,357 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3131,110,471 - 131,224,356 (+)EnsemblGRCm38mm10GRCm38
MGSCv373130,813,389 - 130,926,252 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363131,099,626 - 131,212,489 (+)NCBIMGSCv36mm8
Celera3137,630,007 - 137,744,454 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map360.78NCBI
Lef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82222,340,541 - 222,453,931 (+)NCBIGRCr8
mRatBN7.22219,666,549 - 219,779,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2219,666,592 - 219,779,794 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2227,324,033 - 227,418,775 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02225,223,708 - 225,318,451 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02220,081,321 - 220,176,071 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02236,232,115 - 236,345,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2236,233,239 - 236,345,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02254,781,171 - 254,893,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42228,550,263 - 228,673,131 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12228,537,002 - 228,659,871 (+)NCBI
Celera2211,924,784 - 212,018,812 (+)NCBICelera
Cytogenetic Map2q43NCBI
Lef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554961,728,840 - 1,828,698 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554961,728,840 - 1,827,749 (+)NCBIChiLan1.0ChiLan1.0
LEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23106,146,314 - 106,270,793 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14106,439,278 - 106,565,974 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14111,125,312 - 111,245,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4111,125,312 - 111,245,980 (-)Ensemblpanpan1.1panPan2
LEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13228,516,002 - 28,633,759 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3228,517,108 - 28,634,019 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3213,389,033 - 13,506,807 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03228,744,891 - 28,862,596 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3228,744,919 - 28,862,904 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13228,737,873 - 28,855,560 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03228,482,671 - 28,600,623 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03211,256,345 - 11,374,064 (+)NCBIUU_Cfam_GSD_1.0
Lef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530112,484,346 - 12,597,999 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936818453,635 - 567,469 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936818453,635 - 569,194 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8113,825,161 - 113,944,070 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18113,824,511 - 113,944,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28122,085,854 - 122,204,415 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1755,974,770 - 56,096,214 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl755,990,621 - 56,094,110 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603734,601,310 - 34,723,183 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248301,321,387 - 1,424,389 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248301,320,034 - 1,422,774 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LEF1
27 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3
pathogenic
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
Chr4:4q22.3-28.3
pathogenic
GRCh38/hg38 4q24-25(chr4:105778347-110206873)x3 copy number gain See cases [RCV000051777] Chr4:105778347..110206873 [GRCh38]
Chr4:106699504..111128029 [GRCh37]
Chr4:106918953..111347478 [NCBI36]
Chr4:4q24-25
pathogenic
GRCh38/hg38 4q25(chr4:108142667-108611794)x3 copy number gain See cases [RCV000133816] Chr4:108142667..108611794 [GRCh38]
Chr4:109063823..109532950 [GRCh37]
Chr4:109283272..109752399 [NCBI36]
Chr4:4q25
uncertain significance
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q24-25(chr4:105039193-110409978)x3 copy number gain not provided [RCV000743885] Chr4:105039193..110409978 [GRCh37]
Chr4:4q24-25
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
NM_016269.5(LEF1):c.548-6T>G single nucleotide variant not provided [RCV000915455] Chr4:108083452 [GRCh38]
Chr4:109004608 [GRCh37]
Chr4:4q25
benign
NM_016269.5(LEF1):c.327G>A (p.Ser109=) single nucleotide variant not provided [RCV000964922] Chr4:108163655 [GRCh38]
Chr4:109084811 [GRCh37]
Chr4:4q25
benign
NM_016269.5(LEF1):c.602C>T (p.Pro201Leu) single nucleotide variant Inborn genetic diseases [RCV003248485] Chr4:108083392 [GRCh38]
Chr4:109004548 [GRCh37]
Chr4:4q25
uncertain significance
Single allele duplication not provided [RCV000845097] Chr4:108641272..109259781 [GRCh37]
Chr4:4q25
not provided
NM_016269.5(LEF1):c.253G>A (p.Asp85Asn) single nucleotide variant not provided [RCV000953715] Chr4:108165124 [GRCh38]
Chr4:109086280 [GRCh37]
Chr4:4q25
benign
NM_016269.5(LEF1):c.584C>G (p.Thr195Ser) single nucleotide variant not provided [RCV001356364] Chr4:108083410 [GRCh38]
Chr4:109004566 [GRCh37]
Chr4:4q25
uncertain significance
NM_016269.5(LEF1):c.66GAT[3] (p.Met23dup) microsatellite Ectrodactyly and ectodermal dysplasia without cleft lip/palate [RCV001775057] Chr4:108167696..108167697 [GRCh38]
Chr4:109088852..109088853 [GRCh37]
Chr4:4q25
pathogenic
NM_016269.5(LEF1):c.1042TAT[1] (p.Tyr349del) microsatellite Ectrodactyly [RCV003232418] Chr4:108070732..108070734 [GRCh38]
Chr4:108991888..108991890 [GRCh37]
Chr4:4q25
pathogenic
NM_016269.5(LEF1):c.544del (p.Gln182fs) deletion Ectrodactyly [RCV003232419] Chr4:108089128 [GRCh38]
Chr4:109010284 [GRCh37]
Chr4:4q25
pathogenic
NM_016269.5(LEF1):c.928A>G (p.Met310Val) single nucleotide variant Abnormal radial ray morphology [RCV001780083] Chr4:108078300 [GRCh38]
Chr4:108999456 [GRCh37]
Chr4:4q25
uncertain significance
GRCh37/hg19 4q24-31.21(chr4:104715235-145252595) copy number gain not specified [RCV002053446] Chr4:104715235..145252595 [GRCh37]
Chr4:4q24-31.21
pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21
pathogenic
GRCh37/hg19 4q22.3-25(chr4:95490755-109977216)x3 copy number gain not provided [RCV001827745] Chr4:95490755..109977216 [GRCh37]
Chr4:4q22.3-25
likely pathogenic
NM_016269.5(LEF1):c.597G>T (p.Leu199Phe) single nucleotide variant Inborn genetic diseases [RCV003285142] Chr4:108083397 [GRCh38]
Chr4:109004553 [GRCh37]
Chr4:4q25
uncertain significance
NM_016269.5(LEF1):c.766A>G (p.Thr256Ala) single nucleotide variant Inborn genetic diseases [RCV002864584] Chr4:108079571 [GRCh38]
Chr4:109000727 [GRCh37]
Chr4:4q25
uncertain significance
NM_016269.5(LEF1):c.374A>G (p.Tyr125Cys) single nucleotide variant Inborn genetic diseases [RCV002761761] Chr4:108163608 [GRCh38]
Chr4:109084764 [GRCh37]
Chr4:4q25
uncertain significance
NM_016269.5(LEF1):c.826G>A (p.Asp276Asn) single nucleotide variant Inborn genetic diseases [RCV002783798] Chr4:108079511 [GRCh38]
Chr4:109000667 [GRCh37]
Chr4:4q25
uncertain significance
NM_016269.5(LEF1):c.343A>C (p.Ile115Leu) single nucleotide variant Inborn genetic diseases [RCV002977783] Chr4:108163639 [GRCh38]
Chr4:109084795 [GRCh37]
Chr4:4q25
uncertain significance
NM_016269.5(LEF1):c.530A>T (p.Asp177Val) single nucleotide variant Inborn genetic diseases [RCV002869184] Chr4:108089142 [GRCh38]
Chr4:109010298 [GRCh37]
Chr4:4q25
uncertain significance
NM_016269.5(LEF1):c.745G>A (p.Gly249Ser) single nucleotide variant Inborn genetic diseases [RCV002691770] Chr4:108079592 [GRCh38]
Chr4:109000748 [GRCh37]
Chr4:4q25
uncertain significance
NM_016269.5(LEF1):c.38G>A (p.Gly13Glu) single nucleotide variant Inborn genetic diseases [RCV002835408] Chr4:108167730 [GRCh38]
Chr4:109088886 [GRCh37]
Chr4:4q25
uncertain significance
NM_016269.5(LEF1):c.952G>A (p.Val318Ile) single nucleotide variant Inborn genetic diseases [RCV002652106] Chr4:108078276 [GRCh38]
Chr4:108999432 [GRCh37]
Chr4:4q25
uncertain significance
NM_016269.5(LEF1):c.913G>A (p.Ala305Thr) single nucleotide variant not provided [RCV003332456] Chr4:108078315 [GRCh38]
Chr4:108999471 [GRCh37]
Chr4:4q25
uncertain significance
NM_016269.5(LEF1):c.73C>T (p.Pro25Ser) single nucleotide variant Inborn genetic diseases [RCV003377409] Chr4:108167695 [GRCh38]
Chr4:109088851 [GRCh37]
Chr4:4q25
uncertain significance
NM_016269.5(LEF1):c.887G>A (p.Arg296Lys) single nucleotide variant Inborn genetic diseases [RCV003362539] Chr4:108078341 [GRCh38]
Chr4:108999497 [GRCh37]
Chr4:4q25
uncertain significance
GRCh37/hg19 4q24-35.2(chr4:101203509-190957473)x3 copy number gain not specified [RCV003986496] Chr4:101203509..190957473 [GRCh37]
Chr4:4q24-35.2
pathogenic
GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3 copy number gain not provided [RCV003885507] Chr4:45455621..191003541 [GRCh37]
Chr4:4p12-q35.2
pathogenic
NM_016269.5(LEF1):c.845+14C>T single nucleotide variant LEF1-related condition [RCV003969561] Chr4:108079478 [GRCh38]
Chr4:109000634 [GRCh37]
Chr4:4q25
likely benign
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR218-2hsa-miR-218-5pOncomiRDBexternal_infoNANA22766851

Predicted Target Of
Summary Value
Count of predictions:3671
Count of miRNA genes:1020
Interacting mature miRNAs:1232
Transcripts:ENST00000265165, ENST00000379951, ENST00000438313, ENST00000503879, ENST00000504426, ENST00000504775, ENST00000504950, ENST00000505293, ENST00000505297, ENST00000505328, ENST00000505379, ENST00000506680, ENST00000507470, ENST00000509428, ENST00000510135, ENST00000510624, ENST00000510717, ENST00000512172, ENST00000512407, ENST00000514444, ENST00000515500
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-18753  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374109,069,976 - 109,070,109UniSTSGRCh37
Build 364109,289,425 - 109,289,558RGDNCBI36
Celera4106,364,838 - 106,364,971RGD
Cytogenetic Map4q23-q25UniSTS
HuRef4104,801,466 - 104,801,599UniSTS
TNG Radiation Hybrid Map466512.0UniSTS
Stanford-G3 RH Map46272.0UniSTS
NCBI RH Map41172.5UniSTS
RH121496  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374109,032,156 - 109,032,448UniSTSGRCh37
Build 364109,251,605 - 109,251,897RGDNCBI36
Celera4106,327,019 - 106,327,311RGD
Cytogenetic Map4q23-q25UniSTS
HuRef4104,763,632 - 104,763,924UniSTS
TNG Radiation Hybrid Map466473.0UniSTS
RH122898  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374109,039,583 - 109,039,879UniSTSGRCh37
Build 364109,259,032 - 109,259,328RGDNCBI36
Celera4106,334,446 - 106,334,742RGD
Cytogenetic Map4q23-q25UniSTS
HuRef4104,771,059 - 104,771,355UniSTS
TNG Radiation Hybrid Map466489.0UniSTS
SHGC-154060  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374109,088,469 - 109,088,765UniSTSGRCh37
Build 364109,307,918 - 109,308,214RGDNCBI36
Celera4106,383,332 - 106,383,628RGD
Cytogenetic Map4q23-q25UniSTS
Cytogenetic Map4q25UniSTS
HuRef4104,819,961 - 104,820,249UniSTS
TNG Radiation Hybrid Map466512.0UniSTS
LEF1_1628  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374108,968,607 - 108,969,400UniSTSGRCh37
Build 364109,188,056 - 109,188,849RGDNCBI36
Celera4106,263,419 - 106,264,212RGD
HuRef4104,700,250 - 104,701,043UniSTS
SHGC-18750  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374108,990,661 - 108,990,817UniSTSGRCh37
Build 364109,210,110 - 109,210,266RGDNCBI36
Celera4106,285,459 - 106,285,615RGD
Cytogenetic Map4q23-q25UniSTS
HuRef4104,722,303 - 104,722,459UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 130 235 278 13 746 14 227 25 191 46 568 183 4 77 1
Low 1439 1285 993 298 1137 147 2812 475 3354 314 804 1337 155 1089 1479
Below cutoff 843 1456 435 299 39 291 1283 1654 154 47 46 45 13 111 1204 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_015798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001130713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001130714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001166119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005263046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005263047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005263048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006714233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054350153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054350154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054350155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054350156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007057925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007057926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007057927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008486989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008486990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008486991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC092539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC097067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC118062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC123576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF086339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF198532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF203908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF288570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF288571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF294627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL049409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY129650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC405840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC406065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN230348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN232202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000265165   ⟹   ENSP00000265165
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,047,548 - 108,168,932 (-)Ensembl
RefSeq Acc Id: ENST00000379951   ⟹   ENSP00000369284
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,047,545 - 108,168,956 (-)Ensembl
RefSeq Acc Id: ENST00000438313   ⟹   ENSP00000406176
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,048,417 - 108,167,798 (-)Ensembl
RefSeq Acc Id: ENST00000503879
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,047,573 - 108,078,352 (-)Ensembl
RefSeq Acc Id: ENST00000504426
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,047,592 - 108,071,778 (-)Ensembl
RefSeq Acc Id: ENST00000504775
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,070,662 - 108,167,594 (-)Ensembl
RefSeq Acc Id: ENST00000504950   ⟹   ENSP00000427459
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,078,325 - 108,166,286 (-)Ensembl
RefSeq Acc Id: ENST00000505293
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,083,368 - 108,166,796 (-)Ensembl
RefSeq Acc Id: ENST00000505297
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,048,354 - 108,072,896 (-)Ensembl
RefSeq Acc Id: ENST00000505328
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,070,430 - 108,078,405 (-)Ensembl
RefSeq Acc Id: ENST00000505379
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,048,169 - 108,083,413 (-)Ensembl
RefSeq Acc Id: ENST00000506680   ⟹   ENSP00000422334
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,063,629 - 108,167,767 (-)Ensembl
RefSeq Acc Id: ENST00000507470
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,048,527 - 108,070,895 (-)Ensembl
RefSeq Acc Id: ENST00000509428
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,048,597 - 108,165,195 (-)Ensembl
RefSeq Acc Id: ENST00000510135
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,048,377 - 108,165,255 (-)Ensembl
RefSeq Acc Id: ENST00000510624   ⟹   ENSP00000422840
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,048,639 - 108,166,721 (-)Ensembl
RefSeq Acc Id: ENST00000510717
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,081,621 - 108,165,257 (-)Ensembl
RefSeq Acc Id: ENST00000512172   ⟹   ENSP00000427365
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,083,213 - 108,166,301 (-)Ensembl
RefSeq Acc Id: ENST00000512407
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,048,635 - 108,072,251 (-)Ensembl
RefSeq Acc Id: ENST00000514444
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,048,300 - 108,078,382 (-)Ensembl
RefSeq Acc Id: ENST00000515500   ⟹   ENSP00000422801
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl4108,081,584 - 108,166,797 (-)Ensembl
RefSeq Acc Id: NM_001130713   ⟹   NP_001124185
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,047,548 - 108,168,932 (-)NCBI
GRCh374108,968,701 - 109,090,112 (-)ENTREZGENE
HuRef4104,700,344 - 104,821,596 (-)ENTREZGENE
CHM1_14108,945,152 - 109,066,566 (-)NCBI
T2T-CHM13v2.04111,349,885 - 111,471,256 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001130714   ⟹   NP_001124186
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,047,548 - 108,168,932 (-)NCBI
GRCh374108,968,701 - 109,090,112 (-)ENTREZGENE
HuRef4104,700,344 - 104,821,596 (-)ENTREZGENE
CHM1_14108,945,152 - 109,066,566 (-)NCBI
T2T-CHM13v2.04111,349,885 - 111,471,256 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001166119   ⟹   NP_001159591
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,047,548 - 108,166,301 (-)NCBI
GRCh374108,968,701 - 109,090,112 (-)ENTREZGENE
HuRef4104,700,344 - 104,821,596 (-)ENTREZGENE
CHM1_14108,945,152 - 109,064,407 (-)NCBI
T2T-CHM13v2.04111,349,885 - 111,468,625 (-)NCBI
Sequence:
RefSeq Acc Id: NM_016269   ⟹   NP_057353
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,047,548 - 108,168,932 (-)NCBI
GRCh374108,968,701 - 109,090,112 (-)ENTREZGENE
Build 364109,188,150 - 109,309,027 (-)NCBI Archive
HuRef4104,700,344 - 104,821,596 (-)ENTREZGENE
CHM1_14108,945,152 - 109,066,566 (-)NCBI
T2T-CHM13v2.04111,349,885 - 111,471,256 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005263046   ⟹   XP_005263103
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,047,548 - 108,168,932 (-)NCBI
GRCh374108,968,701 - 109,090,112 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005263047   ⟹   XP_005263104
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,047,548 - 108,166,301 (-)NCBI
GRCh374108,968,701 - 109,090,112 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005263048   ⟹   XP_005263105
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,047,548 - 108,166,301 (-)NCBI
GRCh374108,968,701 - 109,090,112 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006714233   ⟹   XP_006714296
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,047,548 - 108,166,939 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054350153   ⟹   XP_054206128
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04111,349,885 - 111,471,256 (-)NCBI
RefSeq Acc Id: XM_054350154   ⟹   XP_054206129
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04111,349,885 - 111,468,625 (-)NCBI
RefSeq Acc Id: XM_054350155   ⟹   XP_054206130
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04111,349,885 - 111,468,625 (-)NCBI
RefSeq Acc Id: XM_054350156   ⟹   XP_054206131
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04111,349,885 - 111,469,647 (-)NCBI
RefSeq Acc Id: XR_007057925
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,070,658 - 108,168,932 (-)NCBI
RefSeq Acc Id: XR_007057926
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,070,658 - 108,168,932 (-)NCBI
RefSeq Acc Id: XR_007057927
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,070,658 - 108,166,301 (-)NCBI
RefSeq Acc Id: XR_008486989
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04111,372,989 - 111,471,256 (-)NCBI
RefSeq Acc Id: XR_008486990
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04111,372,989 - 111,471,256 (-)NCBI
RefSeq Acc Id: XR_008486991
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04111,372,989 - 111,468,625 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001124185 (Get FASTA)   NCBI Sequence Viewer  
  NP_001124186 (Get FASTA)   NCBI Sequence Viewer  
  NP_001159591 (Get FASTA)   NCBI Sequence Viewer  
  NP_057353 (Get FASTA)   NCBI Sequence Viewer  
  XP_005263103 (Get FASTA)   NCBI Sequence Viewer  
  XP_005263104 (Get FASTA)   NCBI Sequence Viewer  
  XP_005263105 (Get FASTA)   NCBI Sequence Viewer  
  XP_006714296 (Get FASTA)   NCBI Sequence Viewer  
  XP_054206128 (Get FASTA)   NCBI Sequence Viewer  
  XP_054206129 (Get FASTA)   NCBI Sequence Viewer  
  XP_054206130 (Get FASTA)   NCBI Sequence Viewer  
  XP_054206131 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF13268 (Get FASTA)   NCBI Sequence Viewer  
  AAG01022 (Get FASTA)   NCBI Sequence Viewer  
  AAG26886 (Get FASTA)   NCBI Sequence Viewer  
  AAH40559 (Get FASTA)   NCBI Sequence Viewer  
  AAH50632 (Get FASTA)   NCBI Sequence Viewer  
  AAK64602 (Get FASTA)   NCBI Sequence Viewer  
  AAN06089 (Get FASTA)   NCBI Sequence Viewer  
  AEW16365 (Get FASTA)   NCBI Sequence Viewer  
  BAG57649 (Get FASTA)   NCBI Sequence Viewer  
  BAG64247 (Get FASTA)   NCBI Sequence Viewer  
  BAH13928 (Get FASTA)   NCBI Sequence Viewer  
  CAH56421 (Get FASTA)   NCBI Sequence Viewer  
  EAX06221 (Get FASTA)   NCBI Sequence Viewer  
  EAX06222 (Get FASTA)   NCBI Sequence Viewer  
  EAX06223 (Get FASTA)   NCBI Sequence Viewer  
  EAX06224 (Get FASTA)   NCBI Sequence Viewer  
  EAX06225 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000265165
  ENSP00000265165.1
  ENSP00000369284
  ENSP00000369284.2
  ENSP00000406176
  ENSP00000406176.2
  ENSP00000422334.1
  ENSP00000422801.1
  ENSP00000422840
  ENSP00000422840.1
  ENSP00000427365.1
  ENSP00000427459.1
GenBank Protein Q9UJU2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001124186   ⟸   NM_001130714
- Peptide Label: isoform 3
- UniProtKB: Q9UJU2 (UniProtKB/Swiss-Prot),   Q659G9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001124185   ⟸   NM_001130713
- Peptide Label: isoform 2
- UniProtKB: Q9UJU2 (UniProtKB/Swiss-Prot),   Q659G9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_057353   ⟸   NM_016269
- Peptide Label: isoform 1
- UniProtKB: Q3ZCU4 (UniProtKB/Swiss-Prot),   E9PDK3 (UniProtKB/Swiss-Prot),   B7Z8E2 (UniProtKB/Swiss-Prot),   B4DG38 (UniProtKB/Swiss-Prot),   Q9HAZ0 (UniProtKB/Swiss-Prot),   Q9UJU2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001159591   ⟸   NM_001166119
- Peptide Label: isoform 4
- UniProtKB: B4DZY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005263103   ⟸   XM_005263046
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005263105   ⟸   XM_005263048
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005263104   ⟸   XM_005263047
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006714296   ⟸   XM_006714233
- Peptide Label: isoform X4
- UniProtKB: B4DZY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000406176   ⟸   ENST00000438313
RefSeq Acc Id: ENSP00000427459   ⟸   ENST00000504950
RefSeq Acc Id: ENSP00000422334   ⟸   ENST00000506680
RefSeq Acc Id: ENSP00000369284   ⟸   ENST00000379951
RefSeq Acc Id: ENSP00000422840   ⟸   ENST00000510624
RefSeq Acc Id: ENSP00000427365   ⟸   ENST00000512172
RefSeq Acc Id: ENSP00000422801   ⟸   ENST00000515500
RefSeq Acc Id: ENSP00000265165   ⟸   ENST00000265165
RefSeq Acc Id: XP_054206128   ⟸   XM_054350153
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054206131   ⟸   XM_054350156
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054206130   ⟸   XM_054350155
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054206129   ⟸   XM_054350154
- Peptide Label: isoform X2
Protein Domains
CTNNB1 binding N-teminal   HMG box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UJU2-F1-model_v2 AlphaFold Q9UJU2 1-399 view protein structure

Promoters
RGD ID:6868238
Promoter ID:EPDNEW_H7284
Type:multiple initiation site
Name:LEF1_3
Description:lymphoid enhancer binding factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7285  EPDNEW_H7286  EPDNEW_H7287  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,167,670 - 108,167,730EPDNEW
RGD ID:6868240
Promoter ID:EPDNEW_H7285
Type:initiation region
Name:LEF1_2
Description:lymphoid enhancer binding factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7284  EPDNEW_H7286  EPDNEW_H7287  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,168,424 - 108,168,484EPDNEW
RGD ID:6868242
Promoter ID:EPDNEW_H7286
Type:initiation region
Name:LEF1_4
Description:lymphoid enhancer binding factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7284  EPDNEW_H7285  EPDNEW_H7287  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,168,753 - 108,168,813EPDNEW
RGD ID:6868244
Promoter ID:EPDNEW_H7287
Type:initiation region
Name:LEF1_1
Description:lymphoid enhancer binding factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7284  EPDNEW_H7285  EPDNEW_H7286  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh384108,168,932 - 108,168,992EPDNEW
RGD ID:6802419
Promoter ID:HG_KWN:48880
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   Jurkat,   Lymphoblastoid
Transcripts:UC003HYS.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364109,212,276 - 109,213,177 (-)MPROMDB
RGD ID:6802422
Promoter ID:HG_KWN:48881
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Jurkat
Transcripts:UC010IMA.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364109,218,776 - 109,219,276 (-)MPROMDB
RGD ID:6802418
Promoter ID:HG_KWN:48882
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Jurkat
Transcripts:UC003HYW.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364109,220,426 - 109,220,926 (-)MPROMDB
RGD ID:6802420
Promoter ID:HG_KWN:48883
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   Jurkat,   Lymphoblastoid
Transcripts:NM_001166119
Position:
Human AssemblyChrPosition (strand)Source
Build 364109,307,201 - 109,308,027 (-)MPROMDB
RGD ID:6802425
Promoter ID:HG_KWN:48885
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   Jurkat,   K562,   Lymphoblastoid
Transcripts:NM_001130713,   NM_001130714,   NM_016269,   UC010IMB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364109,308,521 - 109,309,572 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6551 AgrOrtholog
COSMIC LEF1 COSMIC
Ensembl Genes ENSG00000138795 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000265165 ENTREZGENE
  ENST00000265165.6 UniProtKB/Swiss-Prot
  ENST00000379951 ENTREZGENE
  ENST00000379951.6 UniProtKB/Swiss-Prot
  ENST00000438313 ENTREZGENE
  ENST00000438313.6 UniProtKB/Swiss-Prot
  ENST00000504950.5 UniProtKB/TrEMBL
  ENST00000506680.5 UniProtKB/Swiss-Prot
  ENST00000510624 ENTREZGENE
  ENST00000510624.5 UniProtKB/Swiss-Prot
  ENST00000512172.1 UniProtKB/TrEMBL
  ENST00000515500.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000138795 GTEx
HGNC ID HGNC:6551 ENTREZGENE
Human Proteome Map LEF1 Human Proteome Map
InterPro Catenin_binding_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTNNB1-bd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCF/LEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:51176 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 51176 ENTREZGENE
PANTHER PTHR10373 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10373:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CTNNB1_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30331 PharmGKB
PROSITE HMG_BOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HMG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4DG38 ENTREZGENE
  B4DZY5 ENTREZGENE, UniProtKB/TrEMBL
  B7Z8E2 ENTREZGENE
  D6RAB1_HUMAN UniProtKB/TrEMBL
  D6RID7_HUMAN UniProtKB/TrEMBL
  D6RIV1_HUMAN UniProtKB/TrEMBL
  E9PDK3 ENTREZGENE
  G9G139_HUMAN UniProtKB/TrEMBL
  LEF1_HUMAN UniProtKB/Swiss-Prot
  Q3ZCU4 ENTREZGENE
  Q659G9 ENTREZGENE, UniProtKB/TrEMBL
  Q9HAZ0 ENTREZGENE
  Q9UJU2 ENTREZGENE
UniProt Secondary B4DG38 UniProtKB/Swiss-Prot
  B7Z8E2 UniProtKB/Swiss-Prot
  E9PDK3 UniProtKB/Swiss-Prot
  Q3ZCU4 UniProtKB/Swiss-Prot
  Q9HAZ0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 LEF1  lymphoid enhancer binding factor 1    lymphoid enhancer-binding factor 1  Symbol and/or name change 5135510 APPROVED